540 results match your criteria Cardiac Cirrhosis and Congestive Hepatopathy


Takotsubo Cardiomyopathy Following Liver Transplantation: A Report of 2 Cases.

Transplant Proc 2020 Sep 23. Epub 2020 Sep 23.

Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, United States.

Purpose: Takotsubo cardiomyopathy, also called apical ballooning syndrome, is characterized by regional left ventricular systolic dysfunction that resembles myocardial infarction in its initial presentation; however, it lacks angiographic evidence of coronary artery disease. We evaluated the incidence of takotsubo cardiomyopathy following liver transplant at a diverse urban transplant program.

Methods: This is a retrospective review of patients transplanted at a single center between 2017 and 2019. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.07.021DOI Listing
September 2020

Imaging of Fontan-associated liver disease.

Pediatr Radiol 2020 10 18;50(11):1528-1541. Epub 2020 Aug 18.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

The Fontan operation has dramatically altered the natural history of functionally single ventricle congenital heart disease. Patients who have undergone the Fontan operation are living longer and, thus, noncardiac morbidity resulting from the Fontan operation is increasingly being recognized. Fontan-associated liver disease (FALD), one of the chief morbidities following the Fontan operation, is believed to be a multifactorial process that manifests as hepatic congestion and fibrosis, portal hypertension, and development of focal liver lesions, including malignant tumors. Read More

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http://dx.doi.org/10.1007/s00247-020-04776-0DOI Listing
October 2020

Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis.

Int J Med Sci 2020 24;17(5):647-656. Epub 2020 Feb 24.

Department of Oral Physiology, BK21 PLUS Project, Periodontal Diseases Signaling Network Research Center, and Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea, 50611.

Connective tissue growth factor (CTGF), an extracellular matrix protein with various biological functions, is known to be upregulated in multiple chronic diseases such as liver fibrosis and congestive heart failure, but the mechanism it undertakes to cause alveolar bone loss in periodontitis remains elusive. The present study therefore investigates the pathways involving CTGF in chronic periodontitis. RNA sequencing revealed a notable increase in the expression of CTGF in chronic periodontitis tissues. Read More

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http://dx.doi.org/10.7150/ijms.41075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085216PMC
February 2020

Combined hepatocellular-cholangiocarcinoma after tetralogy of Fallot repair: a case report and review of literature.

Pathol Res Pract 2020 May 29;216(5):152908. Epub 2020 Feb 29.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashiku, Fukuoka, 812-8582, Japan. Electronic address:

Background: Liver fibrosis and cancer are serious hepatic complications for patients with congenital heart diseases. We present a rare case of combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) (cHCC-CCA) after the repair of tetralogy of Fallot (TOF).

Case Presentation: A 54-year-old Japanese woman had undergone biventricular repair for TOF at 7 years old. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152908DOI Listing

Relationship between Heart Disease and Liver Disease: A Two-Way Street.

Cells 2020 02 28;9(3). Epub 2020 Feb 28.

Internal Medicine 3, Department of Medicine - DIMED, University of Padova, Via Giustiniani2, 35100 Padova, Italy.

In clinical practice, combined heart and liver dysfunctions coexist in the setting of the main heart and liver diseases because of complex cardiohepatic interactions. It is becoming increasingly crucial to identify these interactions between heart and liver in order to ensure an effective management of patients with heart or liver disease to provide an improvement in overall prognosis and therapy. In this review, we aim to summarize the cross-talk between heart and liver in the setting of the main pathologic conditions affecting these organs. Read More

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http://dx.doi.org/10.3390/cells9030567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140474PMC
February 2020

Comorbidity and stage at diagnosis among lung cancer patients in the US military health system.

Cancer Causes Control 2020 Mar 27;31(3):255-261. Epub 2020 Jan 27.

John P. Murtha Cancer Center Research Program, Uniformed Service University of the Health Sciences and Walter Reed National Military Medical Center, 6720A Rockledge Drive, Suite 310, Bethesda, MD, 20817, USA.

Purpose: We investigated the association between comorbidities and stage at diagnosis among NSCLC patients in the US Military Health System (MHS), which provides universal health care to its beneficiaries.

Methods: The linked data from the Department of Defense's Central Cancer Registry (CCR) and the MHS Data Repository (MDR) were used. The study included 4768 patients with histologically confirmed primary NSCLC. Read More

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http://dx.doi.org/10.1007/s10552-020-01269-1DOI Listing

Indwelling pleural catheters for non-malignant pleural effusions: report on a single centre's 10 years of experience.

BMJ Open Respir Res 2020 01;7(1)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of infectious pleurisy and non-malignant diseases like congestive heart failure (CHF) or liver cirrhosis with hepatic hydrothorax (HH). With regard to the chronic character of the underlying diseases, indwelling pleural catheters (IPC) are increasingly used, not only assuring immediate symptom relief but also potentially leading to pleurodesis without sclerosing agents.

Patients And Methods: In this single-centre retrospective observational study, patient characteristics, procedural variables and outcome in patients with IPC in non-malignant pleural effusion (NMPE) were evaluated and prognostic factors for pleurodesis were identified. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011895PMC
January 2020

Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease.

Clin J Gastroenterol 2020 Jun 19;13(3):434-442. Epub 2019 Nov 19.

Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan.

Mixed connective tissue disease (MCTD) causes multiple organ dysfunctions, such as joint swelling, pulmonary fibrosis and hypertension, and serositis, but hepatopancreatic complications are rare. Here, we report a case of young man who exhibited acute severe liver dysfunction. He also had impaired cardiac function: both ventriculi were hypokinetic, but pulmonary hypertension and pericarditis were not observed. Read More

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http://dx.doi.org/10.1007/s12328-019-01059-6DOI Listing

Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice.

Heliyon 2019 Oct 13;5(10):e02655. Epub 2019 Oct 13.

Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan.

Cachexia is an intractable metabolic disorder that causes extreme weight loss. It is a symptom of many chronic diseases, including cancer, liver failure, congestive heart failure and chronic kidney disease, and there is as yet no effective treatment. While the mechanisms underlying cachexia are complex, it is often accompanied by elevated angiotensin II (Ang II). Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e02655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812207PMC
October 2019

Readmissions for Cirrhosis Within the Healthcare Readmissions Reduction Program: A Hidden Challenge.

Authors:
Zachary Henry

Am J Gastroenterol 2019 09;114(9):1419-1420

Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, Virginia, USA.

With the passage of the Affordable Care Act, the Healthcare Readmissions Reduction Program (HRRP) was implemented, leading to significant reductions in readmissions for congestive heart failure, pneumonia, and myocardial infarction. Patients with cirrhosis have a complex and difficult to manage underlying disease process and are often left out of large policy decisions such as the HRRP although they represent a population at high risk for readmission and other negative outcomes. In this editorial, hospital readmissions in patients with cirrhosis are discussed in the context of the HRRP and evolving models of care. Read More

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http://Insights.ovid.com/crossref?an=00000434-201909000-0000
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http://dx.doi.org/10.14309/ajg.0000000000000368DOI Listing
September 2019
4 Reads

Liver Resection for Nonalcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma.

J Am Coll Surg 2019 11 6;229(5):467-478.e1. Epub 2019 Aug 6.

Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore; Duke-National University of Singapore Medical School, Singapore.

Background: Nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) is on the rise worldwide, but data on long-term outcomes after curative operations are limited. The primary aim of this study was to characterize the perioperative and long-term outcomes after liver resection. The secondary aim was to investigate the influence of the histologic severity of nonalcoholic steatohepatitis and its impact on perioperative outcomes and long-term survival. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.07.012DOI Listing
November 2019
8 Reads
5.122 Impact Factor

Cirrhosis as a Comorbidity in Conditions Subject to the Hospital Readmissions Reduction Program.

Am J Gastroenterol 2019 09;114(9):1488-1495

Department of Gastroenterology and Hepatology, New York Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA.

Introduction: Although the Hospital Readmissions Reduction Program (HRRP) has decreased readmissions in targeted conditions, outcomes in high-risk subgroups are unknown. This study analyzed the impact of cirrhosis as a comorbidity on readmissions in conditions subjected to the HRRP.

Methods: Using a longitudinal analysis of the New York, Florida, and Washington State inpatient databases from 2009 to 2013, adult Medicare beneficiaries with a diagnosis-related group of targeted conditions by the HRRP-pneumonia, congestive heart failure (CHF), and myocardial infarction (MI)-were included. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000257DOI Listing
September 2019
19 Reads

Investigation of congestive heart failure in beef cattle in a feedyard at a moderate altitude in western Nebraska.

J Vet Diagn Invest 2019 Jul 6;31(4):509-522. Epub 2019 Jun 6.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE (Moxley, Steffen).

Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500-3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009-2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. Read More

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http://dx.doi.org/10.1177/1040638719855108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857034PMC
July 2019
7 Reads

Pediatric Fontan Associated Liver Disease: Non-invasive Evaluation with Serologic Markers and Acoustic Radiation Force Impulse (ARFI) Elastography.

Prog Pediatr Cardiol 2019 Jun 6;53:21-27. Epub 2018 Oct 6.

Nationwide Children's Hospital/The Ohio State University Department of Pediatrics/The Heart Center, Division of Pediatric Cardiology 700 Children's Drive. Columbus, OH 43205. United States of America.

Hepatic fibrosis is a significant complication in adult Fontan patients suggesting development as a function of time since the surgery. Children with Fontan circulation are not routinely assessed for development of liver disease. We aimed to evaluate the effectiveness of serologic biomarkers and acoustic radiation force impulse (ARFI) elastography to detect liver disease in pediatric Fontan patients. Read More

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http://dx.doi.org/10.1016/j.ppedcard.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430913PMC

Opioid and benzodiazepine prescription among patients with cirrhosis compared to other forms of chronic disease.

BMJ Open Gastroenterol 2019 14;6(1):e000271. Epub 2019 Apr 14.

University of Michigan, Ann Arbor, Michigan, USA.

Objective: Data on patterns and correlates of opioid and benzodiazepines prescriptions among patients with chronic conditions are limited. Given a diminished capacity for hepatic clearance, patients with cirrhosis represent a high risk group for use. The aim of this study was to characterise the patterns and correlates of prescription opioid, benzodiazepine and dual drug prescriptions among individuals with common chronic diseases. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506127PMC
April 2019
17 Reads

Evaluation of Fontan liver disease: Correlation of transjugular liver biopsy with magnetic resonance and hemodynamics.

Congenit Heart Dis 2019 Jul 30;14(4):600-608. Epub 2019 Apr 30.

Division of Pediatric Cardiology, University of California San Diego and Rady Children's Hospital, USA.

Introduction: Liver fibrosis and cirrhosis are late complications in Fontan palliation. Liver biopsy is the gold standard. The goal of this study is to correlate transjugular liver biopsy (TJLB) in the setting of Fontan palliation with noninvasive testing and hemodynamics. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/chd.12770
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http://dx.doi.org/10.1111/chd.12770DOI Listing
July 2019
19 Reads

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot.

Int J Cardiol 2019 07 11;287:121-126. Epub 2019 Apr 11.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Background: Congestive hepatopathy and hepatocellular carcinoma is a serious complication after Fontan procedure. Liver fibrosis due to hepatic congestion could occur also in adult patients after repair of tetralogy of Fallot (rTOF). However, the incidence and severity remain unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183676
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http://dx.doi.org/10.1016/j.ijcard.2019.04.032DOI Listing
July 2019
25 Reads

Validation of a Congestive Hepatic Fibrosis Scoring System.

Am J Surg Pathol 2019 06;43(6):766-772

Departments of Pathology.

Congestive hepatopathy is a complication of right heart failure and chronically elevated right heart pressure. Histologic findings include sinusoidal dilatation, centrilobular hepatocellular plate atrophy, and fibrosis. We performed a validation study of a recently proposed scoring system (0 to 4 scale) for congestive hepatic fibrosis on 38 liver biopsies. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001250DOI Listing
June 2019
20 Reads

Differential diagnosis of ascites in internal medicine: clinical case.

Ter Arkh 2018 Aug;90(8):74-80

B.V. Petrovsky Russian Scientific Center of Surgery, Moscow, Russia.

Ascites and hydrothorax may be the symptoms of congestive heart failure and do not always reflects presense of the decompensated liver cirrhosis. Clinical examination of patient with chronic hepatitis C which cyanosis of the lips, cervival veins pulsation, a triple heart rhythm indicated on pathology of the heart (constrictive pericarditis), which was confirmed by instrumental methods. Congestive heart failure has lead to the congestive liver in a young female patient. Read More

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http://dx.doi.org/10.26442/terarkh201890874-80DOI Listing
August 2018
22 Reads

Percutaneous cholecystostomy-tube for high-risk patients with acute cholecystitis: current practice and implications for future research.

Surg Endosc 2019 10 2;33(10):3396-3403. Epub 2019 Jan 2.

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, 2nd floor, Columbus, OH, USA.

Background: While cholecystectomy (CCY) is the standard of care for gallstone-related acute cholecystitis, percutaneous cholecystostomy-tube (CCYT-tube) is an alternative option in patients with significant comorbid conditions. We sought to identify immediate and longitudinal hospital outcomes of patients who underwent CCYT-tube placement and determine predictors of CCYT-tube placement and eventual CCY on a national level in the US.

Methods: We identified all adults (age ≥ 18 years) with a primary diagnosis of acute calculous cholecystitis from January to November 2013 in the Nationwide Readmissions Database (NRD). Read More

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http://dx.doi.org/10.1007/s00464-018-06634-5DOI Listing
October 2019
5 Reads
3.256 Impact Factor

Heart Failure and Liver Disease: Cardiohepatic Interactions.

JACC Heart Fail 2019 Feb 12;7(2):87-97. Epub 2018 Dec 12.

Department of Cardiology, Larissa University General Hospital, Larissa, Greece. Electronic address:

Heart failure (HF) and liver disease often co-exist. This is because systemic disorders and diseases affect both organs (alcohol abuse, drugs, inflammation, autoimmunity, infections) and because of complex cardiohepatic interactions. The latter, which are the focus of this review, include the development of acute cardiogenic liver injury and congestive hepatopathy in HF as well as cardiac dysfunction and failure in the setting of liver cirrhosis, nonalcoholic fatty liver disease, and sequelae following liver transplantation. Read More

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http://dx.doi.org/10.1016/j.jchf.2018.10.007DOI Listing
February 2019
21 Reads

Clinical characteristics and thromboembolic risk of atrial fibrillation patients with and without congestive heart failure. Results from the CRATF study.

Medicine (Baltimore) 2018 Nov;97(45):e13074

Cardiology Unit, John Paul II Western Hospital, Grodzisk Mazowiecki.

Congestive heart failure (CHF) and atrial fibrillation (AF) frequently coexist and are associated with increased risk of cardiovascular events.To compare baseline characteristics, comorbidities and pharmacotherapy in AF patients with concomitant CHF to those without CHF.The study included 3506 real-life AF patients with (37. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0002
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http://dx.doi.org/10.1097/MD.0000000000013074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250503PMC
November 2018
27 Reads

Significance of congestive heart failure as a cause of pleural effusion: Pilot data from a large multidisciplinary teaching hospital.

Cardiol J 2020 8;27(3):254-261. Epub 2018 Nov 8.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland.

Background: Epidemiological data on the causes of pleural effusion (PE) are scarce. Data on the local prevalence of various causes of PE may play a crucial role in the management strategy of patients with PE. The aim of the study was to investigate the causes of PE and to assess 30-day mortality rate in unselected adult patients treated in a large, multidisciplinary hospital. Read More

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http://dx.doi.org/10.5603/CJ.a2018.0137DOI Listing
November 2018
39 Reads

Transcatheter Aortic Valve Replacement to Treat Liver Decompensation.

CASE (Phila) 2018 Oct 9;2(5):186-191. Epub 2018 Aug 9.

Royal Brompton Hospital, London, United Kingdom.

•Critical aortic stenosis can cause severe biventricular disease.•Painless jaundice can present secondary to severe biventricular failure.•TAVR treats high-risk critical aortic stenosis. Read More

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http://www.cvcasejournal.com/article/S2468644118300513/pdf
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https://www.sciencedirect.com/journal/case
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https://www.ahajournals.org/doi/abs/10.1161/circintervention
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https://linkinghub.elsevier.com/retrieve/pii/S24686441183005
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http://dx.doi.org/10.1016/j.case.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200695PMC
October 2018
42 Reads

Heterogeneity of Fibrosis in Liver Biopsies of Patients With Heart Failure Undergoing Heart Transplant Evaluation.

Am J Surg Pathol 2018 12;42(12):1617-1624

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center.

Liver biopsies are commonly performed in heart transplant candidates to confirm congestive hepatopathy (CH) and to assess the degree of fibrosis. Heterogeneity of fibrosis is frequent in CH, making it difficult to stage fibrosis. In this study, we evaluated the prevalence of heterogeneity of fibrosis and nodular regenerative hyperplasia (NRH) in liver biopsies with CH secondary to heart failure. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001163DOI Listing
December 2018
16 Reads

FibroSURE and elastography poorly predict the severity of liver fibrosis in Fontan-associated liver disease.

Congenit Heart Dis 2018 Sep 12;13(5):764-770. Epub 2018 Aug 12.

Department of Gastroenterology, Greenville Memorial Hospital, Greenville, South Carolina.

Objective: As the population of patients with Fontan circulation surviving into adulthood increases, hepatic cirrhosis has grown to be a significant cause of morbidity and mortality. Early detection of advanced hepatic fibrosis is imperative for proper intervention and consideration for heart or combined heart/liver transplantation. Noninvasive biomarkers and elastography have been evaluated for their diagnostic utility with variable results in the Fontan population. Read More

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http://dx.doi.org/10.1111/chd.12650DOI Listing
September 2018
23 Reads
1.202 Impact Factor

Chronic heart failure in patients with nonalcoholic fatty liver disease: prevalence, clinical features, and relevance.

J Int Med Res 2018 Sep 3;46(9):3959-3969. Epub 2018 Jul 3.

1 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective This study was performed to assess the prevalence of nonalcoholic fatty liver (NAFL) in patients with symptomatic congestive heart failure (CHF) and compare the clinical features with those of patients without NAFL. Methods In total, 102 patients with CHF were divided into NAFL and non-NAFL groups according to their hepatic ultrasonography findings. All patients underwent transthoracic echocardiography and cardiac magnetic resonance examination. Read More

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http://dx.doi.org/10.1177/0300060518782780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135994PMC
September 2018
16 Reads

Risk factors for recurrent bleeding from acute hemorrhagic rectal ulcer.

Scand J Gastroenterol 2018 Jun - Jul;53(7):831-834. Epub 2018 May 31.

a Department of Gastroenterology and Hepatology , Kurashiki Central Hospital , Kurashiki , Japan.

Objectives: Acute hemorrhagic rectal ulcer (AHRU) occurs suddenly with painless massive bleeding from rectal ulcers, usually in patients who have severe underlying disorders. The rate of recurrent bleeding from AHRU is high, but there have been few studies on the risk factors for recurrent bleeding. The aim of this study was to identify risk factors for recurrent bleeding from AHRU. Read More

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http://dx.doi.org/10.1080/00365521.2018.1476912DOI Listing
November 2018
7 Reads

Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience.

World J Hepatol 2018 May;10(5):417-424

Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.

Aim: To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns.

Methods: Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Read More

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http://dx.doi.org/10.4254/wjh.v10.i5.417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971228PMC
May 2018
10 Reads

Increasing Health Care Burden of Chronic Liver Disease Compared With Other Chronic Diseases, 2004-2013.

Gastroenterology 2018 09 23;155(3):719-729.e4. Epub 2018 May 23.

Baylor College of Medicine, Houston, Texas.

Background & Aims: Chronic liver disease (CLD) is a common and expensive condition, and studies of CLD-related hospitalizations have underestimated the true burden of disease. We analyzed data from a large, diverse health care system to compare time trends in CLD-related hospitalizations with those in congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD).

Methods: We collected data from a large health care system in Texas on hospitalizations related to CLD (n = 27,783), CHF (n = 60,415), and COPD (n = 34,199) from January 1, 2004 through December 31, 2013. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.05.032DOI Listing
September 2018
8 Reads

A subclinical high tricuspid regurgitation pressure gradient independent of the mean pulmonary artery pressure is a risk factor for the survival after living donor liver transplantation.

BMC Gastroenterol 2018 May 15;18(1):62. Epub 2018 May 15.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after orthotopic liver transplantation (OLT), as the congestive pressure affects the grafted liver, while subclinical pulmonary hypertension (PH) has been acknowledged as a non-risk factor for deceased donor OLT. Given that PH measurement requires cardiac catheterization, the tricuspid regurgitation pressure gradient (TRPG) measured by echocardiography is used to screen for PH and congestive pressure to the liver. Read More

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http://dx.doi.org/10.1186/s12876-018-0793-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952890PMC
May 2018
49 Reads

Pretransplantation Cystatin C, but not Creatinine, Predicts 30-day Cardiovascular Events and Mortality in Liver Transplant Recipients With Normal Serum Creatinine Levels.

Transplant Proc 2018 May;50(4):1094-1099

Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: The connection between renal dysfunction and cardiovascular dysfunction has been consistently shown. In patients with liver cirrhosis, renal dysfunction shows a tight correlation with prognosis after liver transplantation (LT); therefore, precise renal assessment is mandatory. Cystatin C, a sensitive biomarker for assessing renal function, has shown superiority in detecting mild renal dysfunction compared to classical biomarker creatinine. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183012
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http://dx.doi.org/10.1016/j.transproceed.2018.01.049DOI Listing
May 2018
5 Reads

Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease.

Nat Rev Gastroenterol Hepatol 2018 07;15(7):425-439

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects up to one-quarter of the adult population worldwide. The clinical and economic burden of NAFLD is mainly due to liver-related morbidity and mortality (nonalcoholic steatohepatitis, cirrhosis or hepatocellular carcinoma) and an increased risk of developing fatal and nonfatal cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers (for example, colorectal cancer and breast cancer). Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects. Read More

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http://dx.doi.org/10.1038/s41575-018-0010-0DOI Listing
July 2018
25 Reads

Assessment of Advanced Liver Fibrosis and the Risk for Hepatic Decompensation in Patients With Congestive Hepatopathy.

Hepatology 2018 10 22;68(4):1633-1641. Epub 2018 Sep 22.

Division of Gastroenterology & Hepatology, Department of Medicine.

Congestive hepatopathy (CH) arises from chronically elevated right-sided heart pressures transmitted to the liver by passive venous congestion. Over time, CH can lead to hepatic bridging fibrosis, decompensated cirrhosis, and hepatocellular carcinoma. Currently, there are no evidence-based guidelines to direct appropriate screening or management of patients with CH, partly because of the inability of current clinical tools (serum tests, imaging studies, liver stiffness measurements, and liver biopsy) to accurately estimate hepatic fibrosis or the risk for hepatic decompensation. Read More

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http://doi.wiley.com/10.1002/hep.30048
Publisher Site
http://dx.doi.org/10.1002/hep.30048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173624PMC
October 2018
17 Reads

Using T1 mapping in cardiovascular magnetic resonance to assess congestive hepatopathy.

Abdom Radiol (NY) 2018 10;43(10):2679-2685

Department of Radiology, MLC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

The goal of this study was to assess the ability of quantitative T1 cardiovascular magnetic resonance (CMR) imaging to calculate liver extracellular volume (ECV) in patients with varying degrees of congestive hepatopathy (CH). T1 measurements and ECV calculations were performed retrospectively in three cohorts of patients: normal cardiac function, tetralogy of fallot (TOF) repair and Fontan palliation. All CMR studies included modified look-locker inversion recovery (MOLLI) T1 mapping scans performed pre- and post-injection of a gadolinium-based contrast agent (GBCA). Read More

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http://dx.doi.org/10.1007/s00261-018-1528-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120811PMC
October 2018
16 Reads

Increased Morbidity and Mortality Associated with Falls Among Patients with Cirrhosis.

Am J Med 2018 06 14;131(6):645-650.e2. Epub 2018 Feb 14.

Veterans Affairs Hospital, Ann Arbor, Mich; Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor; Institute for Healthcare Policy and Innovation, Ann Arbor, Mich. Electronic address:

Background: Injuries are more morbid and complicated to manage in patients with cirrhosis. However, data are limited regarding the relative risk of injury and severity of injury from falls in patients with cirrhosis compared with those without cirrhosis.

Methods: We examined the nationally representative National Emergency Department Sample, an all-payer database including all patients presenting with falls, 2009-2012. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.01.026DOI Listing
June 2018
10 Reads

Liver fibrosis marker, 7S domain of collagen type IV, in patients with pre-capillary pulmonary hypertension.

Int J Cardiol 2018 05 8;258:269-274. Epub 2018 Feb 8.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Background: Pulmonary hypertension (PH) causes right ventricular dysfunction and central venous congestion, and may lead to congestive hepatopathy. The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. We aimed to determine whether P4NP 7S is related to hemodynamic parameters, and assessed the potential values of P4NP 7S to predict mortality. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.01.138DOI Listing
May 2018
36 Reads

Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis.

Ann Hepatol 2018 January-February;17(1):119-124

Division of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis Introduction and aim. Critically ill patients in states of circulatory failure are at risk of acute liver injury, from mild elevations in aminotransferases to substantial rises consistent with hypoxic hepatitis or "shock liver". The present study aims to quantify the national prevalence of acute liver injury in patients with hemodynamic instability, identify risk factors for its development, and determine predictors of mortality. Read More

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http://dx.doi.org/10.5604/01.3001.0010.7543DOI Listing
October 2018
14 Reads

Congestive hepatopathy.

Abdom Radiol (NY) 2018 08;43(8):2037-2051

Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Passive hepatic congestion may result from a variety of distinct cardiovascular conditions. Injury to the liver caused by congestion is often asymptomatic and may not be recognized clinically. Diagnosis of congestive hepatopathy is important as it has the potential to cause complications including hepatic fibrosis and development of benign and malignant liver masses. Read More

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http://dx.doi.org/10.1007/s00261-017-1387-xDOI Listing
August 2018
18 Reads

Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment.

Authors:
San-E Ishikawa

J Clin Med 2017 Oct 31;6(11). Epub 2017 Oct 31.

Department of Endocrinology and Metabolism, International University of Health and Welfare Hospital, Nasushiobara 329-2763, Tochigi, Japan.

Exaggerated release of arginine vasopressin (AVP) is profoundly involved in impaired water excretion and related hyponatremia. Such disorders underlie syndromes of inappropriate secretion of antidiuretic hormone (SIADH) and edematous diseases, such as congestive heart failure and decompensated liver cirrhosis. All the causes are fundamentally from non-endocrine diseases. Read More

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http://dx.doi.org/10.3390/jcm6110102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704119PMC
October 2017
6 Reads

Severity of coronary artery disease is associated with non-alcoholic fatty liver dis-ease: A single-blinded prospective mono-center study.

PLoS One 2017 26;12(10):e0186720. Epub 2017 Oct 26.

Department of Internal Medicine 1, Hospital of the Goethe University, Frankfurt, Germany.

Background And Aims: Liver steatosis has shown to be associated with coronary artery disease (CAD). The aim of our study was to evaluate the association between the presence and severity of CAD and Non-alcoholic fatty liver disease (NAFLD) assessed by transient elastography (TE) and controlled attenuation parameter (CAP).

Methods: 576 Patients undergoing coronary angiography were enrolled in this prospective study, receiving at least 10 TE and CAP measurements using the FibroScan® M-probe. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186720PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658076PMC
November 2017
44 Reads

Anesthetic management during the first combined heart-liver transplant performed in Korea: a case report.

Korean J Anesthesiol 2017 Oct 14;70(5):571-576. Epub 2017 Jun 14.

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Herein, we describe the anesthetic management during the first combined heart-liver transplant (CHLT) performed in Korea. Though CHLT is a rare procedure, accumulating evidence suggests that it is a feasible option for patients with coexisting heart and liver failure. A 45-year-old female patient presented with severe cardiac dysfunction requiring extracorporeal membrane oxygenation (ECMO) support and secondary congestive hepatopathy. Read More

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http://dx.doi.org/10.4097/kjae.2017.70.5.571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645592PMC
October 2017
10 Reads

Benign nodules in post-Fontan livers can show imaging features considered diagnostic for hepatocellular carcinoma.

Abdom Radiol (NY) 2017 11;42(11):2623-2631

Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Purpose: To describe the imaging appearance of hyperenhancing nodules arising in post-Fontan patients and to identify specific features best correlated with malignancy.

Methods: Hyperenhancing hepatic nodules visible on CT and/or MRI in post-Fontan patients were identified retrospectively and reviewed by subspecialty radiologists. Nodules with characteristic imaging findings of focal nodular hyperplasia (FNH) were defined as typical, the remainder were defined as atypical, described in detail according to LIRADS criteria, and length of stability over time was recorded. Read More

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http://dx.doi.org/10.1007/s00261-017-1181-9DOI Listing
November 2017
41 Reads

Histology and Glutamine Synthetase Immunoreactivity in Liver Biopsies From Patients With Congestive Heart Failure.

Gastroenterology Res 2017 Jun 30;10(3):182-189. Epub 2017 Jun 30.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.

Background: Long-standing congestive heart failure can induce a constellation of histopathology changes in the liver that can range from mild sinusoidal dilation to advanced fibrosis and loss of normal perivenular expression of glutamine synthetase (GS). Liver biopsies might be performed to assess the perioperative risk of these patients or to determine the need of synchronous liver transplant. We aimed to assess interobserver agreement in recognizing these liver histologic features in patients undergoing evaluation for heart transplantation and to examine whether immunohistochemistry of GS will aid the diagnosis of cardiac hepatopathy (CH). Read More

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http://dx.doi.org/10.14740/gr875eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505284PMC
June 2017
16 Reads

Impact of Cirrhosis in Patients Who Underwent Surgical Aortic Valve Replacement.

Am J Cardiol 2017 Aug 30;120(4):648-654. Epub 2017 May 30.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Cirrhosis is known to adversely affect cardiac surgery outcomes. Our objective was to quantify the morbidity, mortality, and cost that cirrhosis adds to surgical aortic valve replacement. From 1998 to 2011, 423,789 patients in the Nationwide Inpatient Sample Healthcare Cost Utilization Project underwent isolated aortic valve replacement; 2,769 (0. Read More

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http://dx.doi.org/10.1016/j.amjcard.2017.05.034DOI Listing
August 2017
30 Reads

Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure.

Open Heart 2017 28;4(1):e000598. Epub 2017 Apr 28.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Objective: Liver dysfunction due to heart failure (HF) is known as congestive hepatopathy. It has recently been reported that liver stiffness assessed by transient elastography reflects increased central venous pressure. The Fibrosis-4 (FIB4) index (age (years) × aspartate aminotransferase (IU/L)/platelet count (10/L) × square root of alanine aminotransferase (IU/L)) is expected to be useful for evaluating liver stiffness in patients with non-alcoholic fatty liver disease. Read More

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http://dx.doi.org/10.1136/openhrt-2017-000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471867PMC
April 2017
56 Reads

FIB-4 stage of liver fibrosis predicts incident heart failure among HIV-infected and uninfected patients.

Hepatology 2017 10 30;66(4):1286-1295. Epub 2017 Aug 30.

Vanderbilt University School of Medicine, Nashville, TN.

Liver fibrosis is common, particularly in individuals who are infected with human immunodeficiency virus (HIV). HIV-infected individuals have excess congestive heart failure (CHF) risk compared with uninfected people. It remains unknown whether liver fibrosis stage influences the CHF risk or if HIV or hepatitis C virus (HCV) infection modifies this association. Read More

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http://dx.doi.org/10.1002/hep.29285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609079PMC
October 2017
75 Reads

Heart Disease and the Liver: Pathologic Evaluation.

Gastroenterol Clin North Am 2017 06;46(2):421-435

Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, PH 15 West, Rm 1574, New York, NY 10032-3725, USA. Electronic address:

Liver injury due to acute and chronic heart failure has long been recognized. This article discusses the concepts of acute cardiogenic liver injury (ACLI) and cardiac or congestive hepatopathy (CH) along with their clinical manifestations and sequelae. Histologically, ACLI manifests as centrilobular hepatocellular necrosis, whereas CH is associated with centrilobular hepatocyte atrophy, dilated sinusoids, and perisinusoidal fibrosis, progressing to bridging fibrosis and ultimately cirrhosis. Read More

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http://dx.doi.org/10.1016/j.gtc.2017.01.012DOI Listing
June 2017
16 Reads

Hepatic Fibrosis Is Universal Following Fontan Operation, and Severity is Associated With Time From Surgery: A Liver Biopsy and Hemodynamic Study.

J Am Heart Assoc 2017 Apr 26;6(5). Epub 2017 Apr 26.

Division of Cardiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Background: Congestive hepatopathy is a recognized complication of Fontan physiology. Data regarding the incidence of hepatopathy and risk factors are lacking.

Methods And Results: Liver biopsies and cardiac catherizations were performed as part of an evaluation offered to all patients ≥10 years after Fontan. Read More

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http://dx.doi.org/10.1161/JAHA.116.004809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524062PMC
April 2017
26 Reads

Safety Profile of Liver FibroScan in Patients with Cardiac Pacemakers or Implantable Cardioverter-Defibrillators.

Can J Gastroenterol Hepatol 2017 27;2017:7298032. Epub 2017 Feb 27.

Division of Gastroenterology, Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

. Emerging evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery diseases and arrhythmias. The FibroScan (Echosens, France), a widely available, noninvasive device, is able to detect liver fibrosis and steatosis within this patient population. Read More

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http://dx.doi.org/10.1155/2017/7298032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350419PMC
January 2018
10 Reads