567 results match your criteria Cardiac Cirrhosis and Congestive Hepatopathy


Non-invasive biomarkers of Fontan-associated liver disease.

JHEP Rep 2021 Dec 14;3(6):100362. Epub 2021 Sep 14.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background & Aims: Fontan-associated liver disease (FALD) has emerged as an important morbidity following surgical palliation of single ventricle congenital heart disease. In this study, non-invasive biomarkers that may be associated with severity of FALD were explored.

Methods: A retrospective cohort of paediatric patients post-Fontan who underwent liver biopsy at a high volume at a paediatric congenital heart disease centre was reviewed. Read More

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December 2021

A Population-Based Cohort Study on Chronic Comorbidity Risk Factors for Adverse Dengue Outcomes.

Am J Trop Med Hyg 2021 Sep 27. Epub 2021 Sep 27.

Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan.

The global burden of dengue is increasing against a background of rising global prevalence of chronic noncommunicable diseases (NCDs) and an epidemiological shift of dengue toward older age groups. The contribution of NCDs toward risk for adverse clinical and healthcare utilization outcomes was assessed in a national linked-database study. About 51,433 adult dengue cases between 2014 and 2015 were assessed for outpatient and inpatient claims data in Taiwan's National Health Insurance Research Database for the 30 days after their dengue diagnosis. Read More

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September 2021

Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study.

BMC Infect Dis 2021 Sep 10;21(1):939. Epub 2021 Sep 10.

Department of Medicine, University of Calgary, Calgary, Canada.

Background: Pyogenic liver abscess (PLA), although uncommon in North America, is associated with significant morbidity and mortality. We sought to re-examine the epidemiology, risk factors, and outcomes of PLA in a large, diverse Canadian health zone.

Methods: All Calgary Health Zone (CHZ) residents aged ≥20 with PLA between 2015 and 2017 were identified. Read More

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September 2021

Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.

Gut 2021 Sep 6. Epub 2021 Sep 6.

Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Objective: Some data suggest a positive association between non-alcoholic fatty liver disease (NAFLD) and incident major adverse cardiovascular events (MACEs). However, data are lacking from large cohorts with liver histology, which remains the gold standard for staging NAFLD severity.

Design: This population-based cohort included all Swedish adults with histologically confirmed NAFLD and without cardiovascular disease (CVD) at baseline (1966-2016, n=10 422). Read More

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September 2021

Review article: non-alcoholic fatty liver disease and cardiovascular diseases: associations and treatment considerations.

Aliment Pharmacol Ther 2021 10 20;54(8):1013-1025. Epub 2021 Aug 20.

UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, UK.

Background: There are increasing data on the association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD).

Aim: To summarise evidence on the association between NAFLD and CVD in the clinical setting and provide potential therapeutic implications.

Methods: We searched PubMed. Read More

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October 2021

Predictors of mortality in adult patients with methicillin-resistant Staphylococcus aureus bloodstream infection: a meta-analysis and systematic review.

Ann Palliat Med 2021 Aug 5;10(8):8617-8627. Epub 2021 Aug 5.

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.

Background: Cases of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection have been increasing. Patients with MRSA bloodstream infection have a poor prognosis and high mortality rate. Identification of potential risk factors associated with MRSA bloodstream infection-related mortality may help improve patient outcomes. Read More

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Reply to: "Combined heart-liver transplantation for congestive hepatopathy with bridging fibrosis: Is it warranted?"

JHEP Rep 2021 Aug 3;3(4):100327. Epub 2021 Jul 3.

Sorbonne Université, Service d'Hépatologie, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, AP-HP, Paris, France.

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Combined heart-liver transplantation for congestive hepatopathy with bridging fibrosis: Is it warranted?

JHEP Rep 2021 Aug 22;3(4):100292. Epub 2021 Apr 22.

Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.

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In-hospital outcomes of transcatheter versus surgical mitral valve repair in patients with chronic liver disease.

Int J Clin Pract 2021 Oct 4;75(10):e14660. Epub 2021 Aug 4.

Department of Cardiology, University of Massachusetts Medical School, Baystate Medical Center, Springfield, Massachusetts, USA.

Background: Mitral valve transcatheter edge-to-edge repair (TEER) using MitraClip is a treatment option for patients with moderate to severe mitral regurgitation who are not surgical candidate. Liver cirrhosis is associated with higher operative morbidity and mortality; however, it is not part of preoperative risk assessments calculators. We sought to evaluate the in-hospital outcomes in TEER and surgical mitral valve repair (SMVR) in liver cirrhosis. Read More

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October 2021

A case report of hepatocellular carcinoma derived from Rastelli procedure-related congestive liver disease.

Clin J Gastroenterol 2021 Oct 28;14(5):1525-1529. Epub 2021 Jul 28.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

The prognosis of congenital heart disease in children has improved, but late complications in adulthood are becoming an important problem. One late complication after congenital heart surgery is congestive liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The Rastelli procedure is one of the surgical methods for transposition of the great arteries. Read More

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October 2021

Prognostic Value of Liver Stiffness Measured by Two-Dimensional Elastography in Acute Decompensated Heart Failure with Preserved Ejection Fraction.

Int Heart J 2021 Jul 17;62(4):821-828. Epub 2021 Jul 17.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine.

Liver stiffness (LS) assessed by ultrasound elastography reflects right-sided filling pressure and offers additional prognostic information in patients with acute decompensated heart failure (ADHF). However, the prognostic value of LS in heart failure (HF) with preserved ejection fraction (HFpEF) remains unclear. This study aimed to investigate the prognostic value of LS measured by two-dimensional shear wave elastography (2D-SWE) in patients with HFpEF. Read More

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Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care.

Int Heart J 2021 Jul 17;62(4):858-865. Epub 2021 Jul 17.

Department of Cardiovascular Medicine, Nippon Medical School.

The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with chronic hepatic diseases. It was calculated using the following formula: (age × aspartate aminotransferase [U/L]) / (platelet count [10/μL] × √alanine aminotransferase [U/L]). However, the clinical impact of the FIB4 index in the acute phase of acute heart failure (AHF) has not been sufficiently investigated. Read More

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Higher liver stiffness in patients with chronic congestive heart failure: data from NHANES with liver ultrasound transient elastography.

Ann Palliat Med 2021 Jun;10(6):6859-6866

Department of Radiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Liver stiffness in patients with chronic congestive heart failure (CCHF) is poorly understood and liver ultrasound transient elastography (LUTE) is a new non-invasive method to detect this condition. In this cross-sectional study we explored liver stiffness and secondary congestive hepatopathy in patients with CCHF detected by LUTE.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES 2017-2018) were analyzed. Read More

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Prognostic significance of liver stiffness assessed by fibrosis-4 index in patients with heart failure.

ESC Heart Fail 2021 Oct 22;8(5):3809-3821. Epub 2021 Jun 22.

Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Center for Metabolic Regulation of Healthy Aging (CMHA), Kumamoto University, Kumamoto, Japan.

Background: Heart failure (HF)-related congestive hepatopathy is a well-recognized problem in management of HF. The fibrosis-4 (FIB4) index calculated by [age × aspartate aminotransferase (IU/L)/platelet count (10 /L) × square root of alanine aminotransferase (IU/L)] is useful for evaluating liver stiffness. We aimed to investigate the impact of the FIB4 index on prognosis in patients with HF. Read More

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October 2021

Carotid approach to anterior circulation thromboembolectomy in an adult with failing fontan physiology: a case report.

BMC Anesthesiol 2021 05 18;21(1):151. Epub 2021 May 18.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, NY, New York, USA.

Background: Anesthetic management of an adult with failing Fontan physiology is complicated given inherent anatomical and physiological alterations. Neurosurgical interventions including thromboembolectomy may be particularly challenging given importance of blood pressure control and cerebral perfusion.

Case Presentation: We describe a 29 year old patient born with double outlet right ventricle (DORV) with mitral valve atresia who after multi-staged surgeries earlier in life, presented with failing Fontan physiology. Read More

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Renal vein measurement using ultrasonography in patients with cirrhotic ascites and congestive heart failure.

J Med Ultrason (2001) 2021 Apr 25;48(2):225-234. Epub 2021 Mar 25.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan.

Purpose: Ascites can cause compression of the inferior vena cava (IVC), leading to increased renal venous pressure and renal congestion. Previously, the left renal vein diameter in liver cirrhosis patients with ascites was measured using computed tomography, showing that enlargement of the left renal vein diameter affects the prognosis. Herein, the diameter and flow velocity of the renal veins were measured using ultrasonography. Read More

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Osmotic Demyelination Syndrome in Hospitalized Patients With Cirrhosis: Analysis of the National Inpatient Sample (NIS).

J Clin Gastroenterol 2021 Mar 18. Epub 2021 Mar 18.

Department of Medicine, Division of Gastroenterology and Hepatology, University of California-San Francisco, San Francisco, CA.

Goal: Characterize prevalence of osmotic demyelination syndrome (ODS) in hospitalized patients with cirrhosis.

Background: ODS is a serious complication of rapid serum sodium correction. Patients with cirrhosis experience labile sodium levels related to portal hypertension and diuretic use, often with rapid correction-intentional or unintentional-during hospitalizations. Read More

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From congestive hepatopathy to hepatocellular carcinoma, how can we improve patient management?

JHEP Rep 2021 Apr 27;3(2):100249. Epub 2021 Jan 27.

Service d 'Hépato-Gastroentérologie de nutrition et d'Alcoologie, Groupe Hospitalier Public du Sud de l'Oise, Creil, France.

Heart failure and liver disease often coexist because of systemic disorders and diseases that affect both organs as well as complex cardio-hepatic interactions. Heart failure can cause acute or chronic liver injury due to ischaemia and passive venous congestion, respectively. Congestive hepatopathy is frequently observed in patients with congenital heart disease and after the Fontan procedure, but also in older patients with chronic heart failure. Read More

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Research Priorities in Lymphatic Interventions: Recommendations from a Multidisciplinary Research Consensus Panel.

J Vasc Interv Radiol 2021 05 18;32(5):762.e1-762.e7. Epub 2021 Feb 18.

Clinical Research and Registries Division, SIR Foundation, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Recognizing the increasing importance of lymphatic interventions, the Society of Interventional Radiology Foundation brought together a multidisciplinary group of key opinion leaders in lymphatic medicine to define the priorities in lymphatic research. On February 21, 2020, SIRF convened a multidisciplinary Research Consensus Panel (RCP) of experts in the lymphatic field. During the meeting, the panel and audience discussed potential future research priorities. Read More

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Cirrhotic Cardiomyopathy Predicts Posttransplant Cardiovascular Disease: Revelations of the New Diagnostic Criteria.

Liver Transpl 2021 06;27(6):876-886

Division of Gastroenterology and Hepatology, The Mayo Clinic, Rochester, MN.

The diagnostic criteria for cirrhotic cardiomyopathy (CCM) were recently revised to reflect the contemporary advancements in echocardiographic technology. This study evaluates the prevalence of CCM, according to the new criteria, and its impact on posttransplant cardiovascular disease (CVD). This is a single-center retrospective matched cohort study of liver transplantation (LT) recipients who underwent LT between January 1, 2008 and November 30, 2017. Read More

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Effect of COVID-19 on Pre-existing Liver disease: What Hepatologist Should Know?

J Clin Exp Hepatol 2021 Jul-Aug;11(4):484-493. Epub 2020 Dec 31.

Department of Gastroenterology Sir Ganga Ram Hospital New Delhi, India.

COVID-19 is characterized by predominant respiratory and gastrointestinal symptoms. Liver enzymes derangement is seen in 15-55% of the patients. Advanced age, hypertension, diabetes, obesity, malignancy, and cardiovascular disease predispose them to severe disease and the need for hospitalization. Read More

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December 2020

Part 1: Disease of the Heart and Liver: A Relationship That Cuts Both Ways.

Cardiol Rev 2020 Dec 17. Epub 2020 Dec 17.

From the Department of Medicine, Section of Gastroenterology & Hepatobiliary Diseases New York Medical College and Westchester Medical Center, Valhalla, NY.

The heart and the liver display multifaceted, complex interactions that can be divided into cardiac effects of liver disease, hepatic effects of heart disease, and disease processes affecting both organs. In Part 1 of this 2 part series, we discuss how acute and chronic heart failure can have devastating effects on the liver, such as acute cardiogenic liver injury and congestive hepatopathy. On the other hand, primary liver disease, such as cirrhosis, can lead to a plethora of cardiac insults representative in cirrhotic cardiomyopathy as systolic dysfunction, diastolic dysfunction, and electrophysiological disturbances. Read More

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December 2020

Part 2: Disease of the Heart and Liver: A Relationship That Cuts Both Ways.

Cardiol Rev 2020 Dec 17. Epub 2020 Dec 17.

From the Department of Medicine, Section of Gastroenterology & Hepatobiliary Diseases New York Medical College and Westchester Medical Center, Valhalla, NY.

Diseases known to affect both the heart and liver include a variety of infectious, autoimmune and metabolic disorders, as well as toxins: most commonly alcohol. As damage to both the heart and liver progresses, transplantation is a reasonable therapeutic option. Heart failure patients with underlying congestive hepatopathy receiving cardiac transplant have demonstrated improved liver enzyme levels post-transplant. Read More

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December 2020

Congestive Hepatopathy.

Int J Mol Sci 2020 Dec 10;21(24). Epub 2020 Dec 10.

Gastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.

Liver disease resulting from heart failure (HF) has generally been referred as "cardiac hepatopathy". One of its main forms is congestive hepatopathy (CH), which results from passive venous congestion in the setting of chronic right-sided HF. The current spectrum of CH differs from earlier reports with HF, due to ischemic cardiomyopathy and congenital heart disease having surpassed rheumatic valvular disease. Read More

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December 2020

Transjugular liver biopsy for Fontan associated liver disease surveillance: Technique, outcomes and hemodynamic correlation.

Int J Cardiol 2021 04 2;328:83-88. Epub 2020 Dec 2.

San Diego School of Medicine, Department of Pediatrics, Division of Pediatric Cardiology, University of California, USA.

Background: Fontan associated liver disease (FALD) is attributed to the limitations of the Fontan circulation, resulting in congestive hepatopathy. The technique and outcomes of transjugular liver biopsies (TJLB) in Fontan patients warrant definition as part of a rigorous FALD surveillance program.

Method: Four year review of patients with Fontan physiology who underwent a TJLB during surveillance catheterizations. Read More

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Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors.

PLoS One 2020 27;15(10):e0241357. Epub 2020 Oct 27.

ACALM Study Unit in collaboration with Aston Medical School, Aston University, Birmingham, United Kingdom.

Non-alcoholic fatty liver disease (NAFLD) is common and strongly associated with the metabolic syndrome. Though NAFLD may progress to end-stage liver disease, the top cause of mortality in NAFLD is cardiovascular disease (CVD). Most of the data on liver-related mortality in NAFLD derives from specialist liver centres. Read More

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December 2020

Massive iron overload and acute-on-chronic liver failure in a patient with Diamond-Blackfan anaemia: a case report.

BMC Gastroenterol 2020 Oct 12;20(1):332. Epub 2020 Oct 12.

Department of Pathology, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126, Cidade Universitária Zeferino Vaz, Campinas, SP, 13.083-887, Brazil.

Background: Genetic anaemias lead us to reflect on the classic 'trolley dilemma', when there are two choices but neither one is satisfactory. Either we do not treat anaemia and the patient suffers from chronic tiredness and fatigue, or we do treat it through blood transfusions, leading to iron overload, which is a quite harmful consequence.

Case Presentation: We present the case of a 34-year-old woman with Diamond-Blackfan anaemia (DBA). Read More

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October 2020

Takotsubo Cardiomyopathy Following Liver Transplantation: A Report of 2 Cases.

Transplant Proc 2021 Jan-Feb;53(1):239-243. Epub 2020 Sep 24.

Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, United States.

Purpose: Takotsubo cardiomyopathy, also called apical ballooning syndrome, is characterized by regional left ventricular systolic dysfunction that resembles myocardial infarction in its initial presentation; however, it lacks angiographic evidence of coronary artery disease. We evaluated the incidence of takotsubo cardiomyopathy following liver transplant at a diverse urban transplant program.

Methods: This is a retrospective review of patients transplanted at a single center between 2017 and 2019. Read More

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Imaging of Fontan-associated liver disease.

Pediatr Radiol 2020 10 18;50(11):1528-1541. Epub 2020 Aug 18.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

The Fontan operation has dramatically altered the natural history of functionally single ventricle congenital heart disease. Patients who have undergone the Fontan operation are living longer and, thus, noncardiac morbidity resulting from the Fontan operation is increasingly being recognized. Fontan-associated liver disease (FALD), one of the chief morbidities following the Fontan operation, is believed to be a multifactorial process that manifests as hepatic congestion and fibrosis, portal hypertension, and development of focal liver lesions, including malignant tumors. Read More

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October 2020

Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis.

Int J Med Sci 2020 24;17(5):647-656. Epub 2020 Feb 24.

Department of Oral Physiology, BK21 PLUS Project, Periodontal Diseases Signaling Network Research Center, and Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea, 50611.

Connective tissue growth factor (CTGF), an extracellular matrix protein with various biological functions, is known to be upregulated in multiple chronic diseases such as liver fibrosis and congestive heart failure, but the mechanism it undertakes to cause alveolar bone loss in periodontitis remains elusive. The present study therefore investigates the pathways involving CTGF in chronic periodontitis. RNA sequencing revealed a notable increase in the expression of CTGF in chronic periodontitis tissues. Read More

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December 2020