1,956 results match your criteria Cardiac Calcifications


Iatrogenic embolization following cardiac intervention: postmortem analysis of 110 cases.

Cardiovasc Pathol 2019 Jan 19;40:12-18. Epub 2019 Jan 19.

University of British Columbia, Pathology & Laboratory Medicine, Vancouver, BC, Canada; Vancouver General Hospital, Neuropathology, Vancouver, BC, Canada; St. Paul's Hospital, Pathology & Laboratory Medicine, Vancouver, BC, Canada. Electronic address:

Introduction: Iatrogenic embolization following cardiac investigative procedures may result from hydrophilic polymer emboli (HPE) from catheter valve and vessel wall calcifications, and air embolism from open heart surgery. This retrospective clinical pathologic analysis was undertaken to ascertain the frequency and extent of these potentially fatal complications.

Methods: This retrospective clinical pathologic autopsy analysis with premortem diagnostic imaging correlation identified 110 individuals who had undergone endovascular procedures between 2010 and 2016 within 90 days of death and followed by hospital autopsy. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.01.003DOI Listing
January 2019

Cardiovascular findings on cross-sectional imaging: spectrum of incidental and critical findings and clinical relevance for the abdominal radiologist.

Abdom Radiol (NY) 2019 Feb 8. Epub 2019 Feb 8.

Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Although not the primary focus of the exams, cardiovascular structures are included to some extent on all abdominal or whole-body cross-sectional studies. Cardiovascular findings often present incidentally and may range from chronic to acute and emergent pathologies. Among the most common cardiovascular findings are the presence of cardiac calcifications, most commonly coronary, which correlate with the presence of coronary artery and valvular disease. Read More

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http://dx.doi.org/10.1007/s00261-019-01922-7DOI Listing
February 2019

Sex differences in coronary artery plaque composition detected by coronary computed tomography: quantitative and qualitative analysis.

Neth Heart J 2019 Feb 8. Epub 2019 Feb 8.

Department of Radiology, Innsbruck Medical University, Innsbruck, Austria.

Background: Sex differences in the calculation of coronary heart disease risk have been analysed extensively. However, data on coronary plaque morphology diverge. We analysed plaque characteristics in patients with suspected coronary artery disease (CAD) and defined prognostic factors using coronary computed tomography angiography (CCTA). Read More

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http://dx.doi.org/10.1007/s12471-019-1234-5DOI Listing
February 2019
1 Read

The novel inflammatory marker GlycA and the prevalence and progression of valvular and thoracic aortic calcification: The Multi-Ethnic Study of Atherosclerosis.

Atherosclerosis 2019 Jan 24;282:91-99. Epub 2019 Jan 24.

The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Background And Aims: GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with coronary artery calcium, cardiovascular disease (CVD) events and mortality. Vascular calcifications outside of the coronary arteries are risk markers of CVD and mortality. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.011DOI Listing
January 2019

Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet.

Front Cardiovasc Med 2018 18;5:196. Epub 2019 Jan 18.

UMR 7365 CNRS-Université de Lorraine, IMoPA, Vandoeuvre-lès-Nancy, France.

The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed light on the consequences of loss-of-function mutations for different calcification inhibitors, and genetic targeting of these pathways in mice have generated a clearer picture on the mechanisms involved. For example, generalized arterial calcification of infancy (GACI) is caused by mutations in the enzyme ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (eNPP1), preventing the hydrolysis of ATP into pyrophosphate (PP). Read More

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http://dx.doi.org/10.3389/fcvm.2018.00196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345677PMC
January 2019
1 Read

Comparison of Nongated Chest CT and Dedicated Calcium Scoring CT for Coronary Calcium Quantification Using a 256-Dector Row CT Scanner.

Acad Radiol 2019 Jan 23. Epub 2019 Jan 23.

Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China; Department of Radiology, Affiliated Hospital of Shaanxi Chinese Medicine University, Xianyang 712000, China. Electronic address:

Background: Coronary artery calcification (CAC) is a marker of atherosclerosis and an independent risk factor for cardiac-related mortality and frequently detected on noncontrast chest CT. We aimed to investigate the reliability and accuracy of determining CAC using noncontrast, nongated chest CT with 256-detector row.

Materials And Methods: A total of 1318 patients for chest examination were enrolled to undergo both nongated chest CT and dedicated calcium-scoring CT (CSCT) on a 256-detector row CT scanner. Read More

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http://dx.doi.org/10.1016/j.acra.2018.12.005DOI Listing
January 2019
2 Reads

[Molecular mechanism of vascular calcification.]

Clin Calcium 2019 ;29(2):157-163

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Intimal and medial calcification are increased with type 1 and type 2 diabetes, metabolic syndrome, chronic kidney disease, and ageing. There are several biological mechanisms through which vascular calcification increases all-cause mortality and atherosclerotic plaque rupture. Arterial medial calcification increases arterial stiffness that causes systolic hypertension and diastolic dysfunction and heart failure. Read More

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http://dx.doi.org/10.20837/4201902157DOI Listing
January 2019
5 Reads

Clinical presentation and management of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):927-939. Epub 2018 Sep 28.

Department of Surgery and Translational Medicine, University of Florence, Bone Metabolic Diseases Unit, University Hospital of Florence, Italy. Electronic address:

The clinical manifestations of hypoparathyroidism are variable and can involve almost any organ system. The main clinical features of the hypoparathyroidism are typically signs or symptoms due to neuromuscular irritability owing to low serum calcium level. In addition to hypocalcemia, hyperphosphatemia can contribute to long-term complications, including extra-skeletal calcifications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183010
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http://dx.doi.org/10.1016/j.beem.2018.09.007DOI Listing
December 2018
3 Reads

Sex Differences in Coronary Artery and Thoracic Aorta Calcification and Their Association With Cardiovascular Mortality in Heavy Smokers.

JACC Cardiovasc Imaging 2019 Jan 16. Epub 2019 Jan 16.

Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.

Objectives: The aim of this study was to investigate sex differences in the prevalence, extent, and association of coronary artery calcium (CAC) and thoracic aorta calcium (TAC) scores with cardiovascular mortality in a population eligible for lung screening.

Background: CAC and TAC scores derived from chest computed tomography (CT) might be useful biomarkers for individualized cardiovascular disease prevention and could be especially relevant in high-risk populations such as heavy smokers. Therefore, it is important to know the prevalence of arterial calcifications in male and female heavy smokers, and if there are differences in the predictive value calcifications carry. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.026DOI Listing
January 2019

Risk factors for atrioventricular block after transcatheter aortic valve implantation: a single-centre analysis including assessment of aortic calcifications and follow-up.

Europace 2019 Jan 9. Epub 2019 Jan 9.

Department of Cardiac Surgery, Cardiovascular Center, Klinikum Nürnberg - Paracelsus Medical University, Breslauer Str. 201, Nuremberg, Germany.

Aims: To assess the contribution of aortic valve calcification to the occurrence of transient or permanent atrioventricular block (AVB) and the need for permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) in a large single-centre cohort.

Methods And Results: We retrospectively analysed pre-operative contrast-enhanced multidetector computed tomography scans of patients who underwent TAVI in our centre between 2012 and 2016. Calcium volume was calculated for each aortic cusp above (aortic valve), and below [left ventricular outflow tract (LVOT)] the basal plane. Read More

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http://dx.doi.org/10.1093/europace/euy316DOI Listing
January 2019
7 Reads

Emerging role of myostatin and its inhibition in the setting of chronic kidney disease.

Kidney Int 2018 Dec 28. Epub 2018 Dec 28.

Department of Nephrology and Nutrition, Centre Hospitalier Lyon SUD, Carmen, CENS, University of Lyon, UCBL, Pierre Bénite, France.

The past two decades have witnessed tremendous progress in our understanding of the mechanisms underlying wasting and cachexia in chronic kidney disease (CKD) and in other chronic illnesses, such as cancer and heart failure. In all these conditions wasting is an effect of the activation of protein degradation in muscle, a response that increases the risk of morbidity and mortality. Major recent advances in our knowledge on how CKD and inflammation affect cellular signaling include the identification of the myostatin (MSTN)/activin system, and its related transcriptional program that promotes protein degradation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183077
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http://dx.doi.org/10.1016/j.kint.2018.10.010DOI Listing
December 2018
11 Reads

Microsurgical clipping of a large ruptured anterior communicating artery aneurysm.

Surg Neurol Int 2018 28;9:233. Epub 2018 Nov 28.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Anterior communicating artery (AComA) aneurysms are the most complex aneurysms of the anterior cerebral circulation. They mostly arise between the dominant A1 and the AComA, and are associated with intraventricular hemorrhage or other aneurysms in around 20%-30% of the cases. Giant and fusiform aneurysms are rare in this location in contrast to the common small ruptured aneurysms. Read More

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http://dx.doi.org/10.4103/sni.sni_345_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287331PMC
November 2018
2 Reads

Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images.

PLoS One 2018 20;13(12):e0209318. Epub 2018 Dec 20.

Image Sciences Institute, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.

Introduction: The amount of coronary artery calcium determined in CT scans is a well established predictor of cardiovascular events. However, high interscan variability of coronary calcium quantification may lead to incorrect cardiovascular risk assignment. Partial volume effect contributes to high interscan variability. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209318PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301689PMC
December 2018
4 Reads

Agatston score of the descending aorta is independently associated with coronary events in a low-risk population.

Open Heart 2018 24;5(2):e000893. Epub 2018 Nov 24.

Department of Cardiology, Maastricht University Medical Center (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.

Objectives: A standard coronary artery calcium scan includes part of the aorta. This additional information is often not included in routine analyses. We aimed to determine the feasibility of assessing the Agatston score of the descending aorta calcification (DAC) on standard coronary calcium scans and the association of this score with coronary events in a low-risk study population. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269642PMC
November 2018

Histopathologic Characterization of Peripheral Arteries in Subjects With Abundant Risk Factors: Correlating Imaging With Pathology.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

CVPath Institute, Gaithersburg, Maryland.

Objectives: The aim of this study was to comprehensively evaluate the pathology of the lower extremity arteries across their entire length in subjects dying with abundant risk factors and to evaluate the clinical and imaging implications of the pathological characteristics.

Background: Lower extremity peripheral arterial disease is a major cause of cardiovascular morbidity, but a systematic characterization of the pathology has never been undertaken.

Methods: Twelve legs were obtained from 8 cadavers with histories of coronary risk factors (median age 82 years, 6 men); 8 of 12 legs were evaluated using computed tomography before the major peripheral arteries were dissected along their entire length. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.08.039DOI Listing
December 2018
2 Reads

Human native endocarditis caused by Streptococcus canis-a case report.

APMIS 2019 Jan;127(1):41-44

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.

We report a very rare case of Streptococcus canis native infective endocarditis in a 73-year-old woman living in close contact with her dog. Her echocardiography showed large calcifications in the mitral annulus, massive regurgitation below the posterior leaflet, and adjacent vegetation. Blood culture was positive for Streptococcus Lancefield group G. Read More

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http://dx.doi.org/10.1111/apm.12905DOI Listing
January 2019
3 Reads

New radiological findings and radiculomegaly in oculofaciocardiodental syndrome with a novel BCOR mutation: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13444

Chairman Emeritus, Kushima Orthodontic Clinic, Abeno, Osaka, Japan.

Rationale: Oculofaciocardiodental syndrome (OFCD) patients who show radiculomegaly are very rare. We treated a new OFCD patient orthodontically, and performed longitudinal observation for 30 years. New findings, termed calcified-dental-papillae (CDPs) beneath open-apices (OAs) of developing radiculomegalies, pulp-stone-like-calcifications (PSLCs) and the process of radiculomegaly development were observed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310535PMC
December 2018
1 Read

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor.

Int J Cardiol 2019 Mar 29;278:243-249. Epub 2018 Nov 29.

Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

Aims: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.11.119DOI Listing
March 2019
3 Reads

Usefulness of the Echocardiographic Calcium Score to Refine Risk of Major Adverse Cardiovascular Events Beyond the Traditional Framingham Risk Score.

Am J Cardiol 2019 Feb 19;123(3):392-395. Epub 2018 Oct 19.

Albert Einstein Medical Center, Division of Cardiology, Philadelphia, Pennsylvania.

Echocardiographic calcifications are associated with major adverse cardiovascular events (MACE). A recently described semiquantitative Global Cardiac Calcium Score (GCCS) has been associated with mortality and stroke, with increasing scores associated with increasing risk. This score assigns points for calcium in the aortic root and valve, mitral valve and annulus, and submitral apparatus, with additional points for restricted leaflet mobility. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.009DOI Listing
February 2019
1 Read

Rotational atherectomy in everyday clinical practice. Association of Cardiovascular Interventions of the Polish Society of Cardiology (Asocjacja Interwencji Sercowo-Naczyniowych Polskiego Towarzystwa Kardiologicznego - AISN PTK): Expert opinion.

Kardiol Pol 2018;76(11):1576-1584

The common use of stents, including antiproliferative drug-eluting stents, has been a major breakthrough in invasive cardiology. Nowadays, a change in the clinical presentation of patients treated with percutaneous coronary intervention (PCI) is observed. The typical clinical characteristics now include advanced age, diabetes, chronic kidney disease, heart failure, and multilevel atherosclerosis. Read More

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http://dx.doi.org/10.5603/KP.2018.0225DOI Listing
January 2018
1 Read

Complementary Role of the Computed Biomodelling through Finite Element Analysis and Computed Tomography for Diagnosis of Transcatheter Heart Valve Thrombosis.

Biomed Res Int 2018 22;2018:1346308. Epub 2018 Oct 22.

Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy.

Introduction: The TAVR procedure is associated with a substantial risk of thrombosis. Current guidelines recommend catheter-based aortic valve implantation for prohibitive-high-risk patients with severe aortic valve stenosis but acknowledge that the aetiology and mechanism of thrombosis are unclear.

Methods: From 2015 to 2018, 607 patients with severe aortic valve stenosis underwent either self-expandable or balloon-expandable catheter-based aortic valve implantation at our institute. Read More

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https://www.hindawi.com/journals/bmri/2018/1346308/
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http://dx.doi.org/10.1155/2018/1346308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217904PMC
October 2018
9 Reads

Suspected Pericardial Tuberculosis Revealed as an Amyloid Pericardial Mass.

Case Rep Hematol 2018 17;2018:8606430. Epub 2018 Oct 17.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine "G. Baccelli", University of Bari Aldo Moro Medical School, Bari, Italy.

Primary systemic amyloidosis is not easily diagnosed. The immunoglobulin deposits are usually localized in the kidney, heart, and liver. We describe an unusual case of a patient suffering from a pericardial amyloidoma with internal calcifications and air bubbles that compressed the right ventricle and shifted the heart to the left. Read More

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https://www.hindawi.com/journals/crihem/2018/8606430/
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http://dx.doi.org/10.1155/2018/8606430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207883PMC
October 2018
18 Reads

The effect of heparin hydrogel embedding on glutaraldehyde fixed bovine pericardial tissues: Mechanical behavior and anticalcification potential.

J Mater Sci Mater Med 2018 Nov 9;29(11):175. Epub 2018 Nov 9.

Department of Mechanical Engineering and Aeronautics, Laboratory of Biomechanics & Biomedical Engineering, University of Patras, Patras, Greece.

Heart valve diseases remain common in industrialized countries. Bioprosthetic heart valves, introduced as free of anticoagulation therapy alternatives to mechanical substitutes. Still they suffer from long term failure due to calcification. Read More

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http://link.springer.com/10.1007/s10856-018-6184-8
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http://dx.doi.org/10.1007/s10856-018-6184-8DOI Listing
November 2018
8 Reads

[Calcific uremic arteriolopathy in hemodialysis patient, review of literature through five cases reports].

Nephrol Ther 2018 Nov 29;14(6):439-445. Epub 2018 Jun 29.

Service de néphrologie-hémodialyse et transplantation rénale, université Cadi Ayyad, CHU Mohammed VI, BP 2360 Principal, avenue Ibn Sina, Marrakech, Maroc.

Calcific uremic arteriolopathy, also called calciphylaxis, is a rare and severe disorder that presents with skin ischemia and necrosis, sometimes it presents with systemic necrosis, the process is secondary to the obliteration of the arterioles first by sub-intimal calcium deposits and then by thrombosis. These lesions can often lead to death due to infectious complications and comorbidities such as diabetes, obesity, arteritis, diffuse vascular calcifications, heart disease and undernutrition. The diagnosis is suggested by the characteristic ischemic skin lesions and their distribution, often bilateral and painful, associeted with calcific uremic arteriolopathy risk factors (phosphocalcic abnormalities, anti-vitamin K). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183013
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http://dx.doi.org/10.1016/j.nephro.2018.04.004DOI Listing
November 2018
13 Reads

An in vitro model quantifying the effect of calcification on the tissue-stent interaction in a stenosed aortic root.

J Biomech 2019 Jan 25;82:109-115. Epub 2018 Oct 25.

MMDRG, Biomechanics Research Centre, Biomedical Engineering, College of Engineering & Informatics, National University of Ireland Galway, Ireland. Electronic address:

Transcatheter Aortic Valves rely on the tissue-stent interaction to ensure that the valve is secured within the aortic root. Aortic stenosis presents with heavily calcified leaflets and it has been proposed that this calcification also acts to secure the valve, but this has never been quantified. In this study, we developed an in vitro calcified aortic root model to quantify the role of calcification on the tissue-stent interaction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219290183077
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http://dx.doi.org/10.1016/j.jbiomech.2018.10.010DOI Listing
January 2019
8 Reads

Effect of Virtual Monoenergetic Images From Spectral Detector Computed Tomography on Coronary Calcium Blooming.

J Comput Assist Tomogr 2018 Nov/Dec;42(6):912-918

Objective: The aim of this study was to investigate the quantitative and qualitative effects of virtual monoenergetic images (VMI) by spectral detector computed tomography (SDCT) on calcium blooming in coronary computed tomography angiography.

Methods: Coronary computed tomography angiography using SDCT was performed on 42 patients with coronary artery calcifications. Stenosis grading by diameter and area of calcified plaques and free lumen using VMI from 70 to 140 keV was performed and compared with measurements by conventional images. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000811DOI Listing
November 2018
7 Reads

Radiological findings of breast involvement in benign and malignant systemic diseases.

Radiol Bras 2018 Sep-Oct;51(5):328-333

Department of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.

Although the primary purpose of periodic mammograms in screening programs is to identify lesions suspected of being carcinomas, the findings are often related to systemic (benign or malignant) diseases, rather than breast cancer. Although the involvement of breast structures in systemic diseases is unusual, it can be included in the differential diagnosis of masses, skin changes, calcifications, asymmetry, and axillary lymphadenopathy. The main diagnostic entities that can be associated with such involvement are diabetes, chronic kidney disease, heart diseases, connective tissue diseases, HIV infection, lymphoma, leukemia, and metastases from primary tumors at other sites. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2016.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198842PMC
October 2018
4 Reads

Disparity in spatial distribution of pericardial calcifications in constrictive pericarditis.

Open Heart 2018 7;5(2):e000835. Epub 2018 Oct 7.

Center for the Diagnosis and Treatment of Pericardial Diseases, Cleveland Clinic, Heart and Vascular Institute, Cleveland, Ohio, USA.

Background: Pericardial calcification is seen among patients with constrictive pericarditis (CP). However, the pattern of pericardial calcium distribution and the association with clinical outcomes and imaging data are not well described.

Methods: This was a retrospective study from 2007 to 2013 to evaluate the pattern of pericardial calcium distribution by CT in CP using a semiquantitative calcium scoring system to calculate total pericardial calcium burden and distribution. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2018-000
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http://dx.doi.org/10.1136/openhrt-2018-000835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196947PMC
October 2018
12 Reads

Acute peri-operative coronary subclavian steal syndrome: A diagnostic and treatment challenge.

J Cardiol Cases 2018 May 22;17(5):155-158. Epub 2018 Mar 22.

Department of Cardiac Surgery, University Hospital Lausanne (CHUV) + Cantonal Hospital Sion, Switzerland.

The coronary subclavian steal syndrome (CSSS) generally occurs during follow up after coronary surgery. The case demonstrates an immediate peri-operative CSSS followed by myocardial infarction, notwithstanding a preoperative computed tomography scan quantifying subclavian artery calcifications as non-stenosing, and a subjective patent blood flow through the transected left internal mammary artery (LIMA). Blood flow inversion in the LIMA to anterior descending artery (LAD) bypass was detected by transit time flow measurement (TTFM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409183000
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http://dx.doi.org/10.1016/j.jccase.2017.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149653PMC
May 2018
1 Read

Bioresorbable vascular scaffold implantation for severely calcified lesions after excimer laser lesion preparation.

Catheter Cardiovasc Interv 2018 Dec 30;92(7):1283-1288. Epub 2018 Sep 30.

Unit of Cardiovascular Interventions, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Bioresorbable vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, CA) temporarily elute antiproliferative drugs and provide vessel support, which then subsequently resorb to allow restoration of normal vessel function and architecture. To attain the best possible results with BVS, a dedicated implantation technique (PSP: adequate lesion preparation, proper sizing, postdilatation) is considered mandatory, and calcified lesions are one of the most challenging lesion subsets for BVS implantation. In five cases with severe calcifications refractory to balloon predilatation, we performed excimer laser catheter ablation (ELCA: Turbo Elite catheter; Spectranetics Corporation, Colorado Springs, CO, USA), which facilitated adequate lesion expansion with high-pressure noncompliant balloon inflation and BVS implantation. Read More

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http://doi.wiley.com/10.1002/ccd.27704
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http://dx.doi.org/10.1002/ccd.27704DOI Listing
December 2018
13 Reads

Sodium-fluoride PET-CT for the non-invasive evaluation of coronary plaques in symptomatic patients with coronary artery disease: a cross-correlation study with intravascular ultrasound.

Eur J Nucl Med Mol Imaging 2018 11 31;45(12):2181-2189. Epub 2018 Aug 31.

Department of Nuclear Medicine, The First Hospital of Shanxi Medical University, Molecular Imaging Precision Medical Collaborative Innovation Center, Taiyuan, 030001, Shanxi Province, China.

Objectives: The aim of this study was to evaluate the F-sodium fluoride (F-NaF) coronary uptake compared to coronary intravascular ultrasound (IVUS) in patients with symptomatic coronary artery disease.

Background: F-NaF PET enables the assessment of vascular osteogenesis by interaction with surface hydroxyapatite, while IVUS enables both identification and quantification of intra-plaque components.

Methods: Forty-four patients with symptomatic coronary artery disease were included in this prospective controlled trial, 32 of them (30 patients with unstable angina and 2 patients with stable angina), representing the final study cohort, got additional IVUS. Read More

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http://dx.doi.org/10.1007/s00259-018-4122-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182395PMC
November 2018
3 Reads
5.380 Impact Factor

Automated Agatston Score Computation in non-ECG Gated CT Scans Using Deep Learning.

Proc SPIE Int Soc Opt Eng 2018 Feb 2;10574. Epub 2018 Mar 2.

Applied Chest Imaging Laboratory. Brigham and Women's Hospital. 1249 Boylston St. Boston. Massachusetts. United States.

Introduction: The Agatston score is a well-established metric of cardiovascular disease related to clinical outcomes. It is computed from CT scans by a) measuring the volume and intensity of the atherosclerotic plaques and b) aggregating such information in an index.

Objective: To generate a convolutional neural network that inputs a non-contrast chest CT scan and outputs the Agatston score associated with it directly, without a prior segmentation of Coronary Artery Calcifications (CAC). Read More

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https://www.spiedigitallibrary.org/conference-proceedings-of
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http://dx.doi.org/10.1117/12.2293681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095680PMC
February 2018
15 Reads

Difference Between Persistent Aneurysm, Regressed Aneurysm, and Coronary Dilation in Kawasaki Disease: An Optical Coherence Tomography Study.

Can J Cardiol 2018 Sep 1;34(9):1120-1128. Epub 2018 Jun 1.

Division of Pediatric Cardiology, CHU Sainte-Justine, Montreal, Quebec, Canada. Electronic address:

Background: Coronary artery (CA) aneurysms are a serious complication of Kawasaki disease (KD). Conventional imaging techniques often described segments with regressed aneurysms as normal, whereas studies have shown significant endothelial dysfunction.

Methods: KD patients with aneurysms scheduled for routine coronary angiography underwent optical coherence tomography (OCT) imaging between 2013 and 2016. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.05.021DOI Listing
September 2018
7 Reads

Subclinical Endocarditis Might be a Hidden Trigger of Early Prosthetic Valve Calcification: A Histological Study.

Heart Surg Forum 2018 07 2;21(4):E300-E304. Epub 2018 Jul 2.

Department of Cardiac Surgery, Dresden Heart Center, Dresden University of Technology, Dresden, Germany.

Objective: Despite various improvements in valve prosthetics, early valve deterioration still occurs, leading to prosthetic failure. Studying the early phase of this deterioration is quite difficult, as the prosthesis to be examined is almost always explanted only after extensive deterioration. The objective of this research is to study the pathology of early valve deterioration in an early stage in order to reveal the possible trigger of the process. Read More

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http://dx.doi.org/10.1532/hsf.1740DOI Listing
July 2018
12 Reads

Echocardiographic calcification score in patients with low/intermediate cardiovascular risk.

Clin Res Cardiol 2019 Feb 6;108(2):194-202. Epub 2018 Aug 6.

Department of Internal Medicine III, Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Purpose: Calcification of aortic valve and mitral annulus is associated with cardiovascular risk factors, morbidity and mortality. Assessment of cardiac calcification with echocardiography is feasible, however, only few structured scoring systems have been established so far with limited prognostic data. This study aimed to evaluate an echocardiographic calcification score (echo-CCS) in patients with low/intermediate cardiovascular risk. Read More

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http://dx.doi.org/10.1007/s00392-018-1343-yDOI Listing
February 2019
5 Reads

Safety and clinical performance of a drug eluting absorbable metal scaffold in the treatment of subjects with de novo lesions in native coronary arteries: Pooled 12-month outcomes of BIOSOLVE-II and BIOSOLVE-III.

Catheter Cardiovasc Interv 2018 Dec 5;92(7):E502-E511. Epub 2018 Aug 5.

Interventional Cardiology MedStar Washington Hospital Center, Washington, District of Columbia.

Objectives: Based on outcomes of the BIOSOLVE-II study, a novel second generation drug-eluting absorbable metal scaffold gained CE-mark in 2016. The BIOSOLVE-III study aimed to confirm these outcomes and to obtain additional 12-month angiographic data.

Background: Bioresorbable scaffolds are intended to overcome possible long-term effects of permanent stents such as chronic vessel wall inflammation, stent crushing, and fractures. Read More

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http://dx.doi.org/10.1002/ccd.27680DOI Listing
December 2018
5 Reads

Multimodality Imaging and Pathologic Assessment in an Adult with Endocardial Fibroelastosis.

CASE (Phila) 2017 Oct 3;1(5):176-178. Epub 2017 Aug 3.

Cardiovascular Imaging Laboratory, Cleveland Clinic, Cleveland, Ohio.

•The authors report a patient with biopsy-proven adult endocardial fibroelastosis.•Transthoracic echocardiography revealed diffuse coarse endocardial calcifications.•Native CT of the chest revealed LV endocardial calcifications. Read More

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http://dx.doi.org/10.1016/j.case.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058245PMC
October 2017

Potentially Common Therapeutic Targets for Multiple Sclerosis and Ischemic Stroke.

Front Physiol 2018 13;9:855. Epub 2018 Jul 13.

Mécanismes Physiopathologiques et Conséquences des Calcifications Cardiovasculaires (EA 7517), Faculty of Pharmacy, University of Picardie Jules Verne, Amiens, France.

Ischemic stroke (IS) and multiple sclerosis (MS) are two pathologies of the central nervous system (CNS). At the first look, this appears to be the only similarity between the two diseases, as they seem quite different. Indeed IS has an acute onset compared to MS which develops chronically; IS is consecutive to blood clot migrating to cerebral blood vessels or decrease in cerebral blood flow following atherosclerosis or decreases in cardiac output, whereas MS is an immune disease associated with neurodegeneration. Read More

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http://dx.doi.org/10.3389/fphys.2018.00855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053536PMC

Correlative Detection of Isolated Single and Multi-Cellular Calcifications in the Internal Elastic Lamina of Human Coronary Artery Samples.

Sci Rep 2018 Jul 20;8(1):10978. Epub 2018 Jul 20.

National Institute of Diabetic and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Histopathology protocols often require sectioning and processing of numerous microscopy slides to survey a sample. Trade-offs between workload and sampling density means that small features can be missed. Aiming to reduce the workload of routine histology protocols and the concern over missed pathology in skipped sections, we developed a prototype x-ray tomographic scanner dedicated to rapid scouting and identification of regions of interest in pathology specimens, thereby allowing targeted histopathology analysis to replace blanket searches. Read More

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http://dx.doi.org/10.1038/s41598-018-29379-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054664PMC
July 2018
8 Reads

The role of computed tomography in the planning of transcatheter aortic valve implantation: a retrospective analysis in 200 procedures.

J Cardiovasc Med (Hagerstown) 2018 Oct;19(10):571-578

Fondazione PTV Policlinico Tor Vergata, Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, Rome, Italy.

Aim: The aim of our study is to show the importance of multislice computed tomography (CT) assessment in the overall management and diagnostic framework of transcatheter aortic valve replacement (TAVI) procedure candidates.

Methods: Between June 2015 and April 2017, 200 patients with severe aortic stenosis, not eligible for surgery, were enrolled, as defined by EuroSCORE; they were submitted to TAVI at the interventional cardiology department of the Tor Vergata Polyclinic. CT studies were performed using a 64-slice scanner. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000695DOI Listing
October 2018
11 Reads

Comparison of outcomes in patients undergoing rotational atherectomy after unsuccessful coronary angioplasty versus elective rotational atherectomy.

Postepy Kardiol Interwencyjnej 2018 19;14(2):128-134. Epub 2018 Jun 19.

Third Department of Cardiology, SMDZ in Zabrze, Silesian Center for Heart Disease, Medical University of Silesia in Katowice, Poland.

Introduction: Revascularization of patients with heavily calcified coronary arteries can be a challenge for interventional cardiologists. The procedural success rate in these patients can be improved by using rotational atherectomy (RA).

Aim: To compare in-hospital outcomes and those at 12-month follow-up between patients who underwent RA as a bailout procedure secondary to failed conventional angioplasty or as an elective procedure. Read More

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http://dx.doi.org/10.5114/aic.2018.76403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041843PMC
June 2018
10 Reads

Nanosecond pulsed electric field induces calcium mobilization in osteoblasts.

Bioelectrochemistry 2018 Dec 23;124:7-12. Epub 2018 Jun 23.

Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, PR China; Central Laboratory, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, PR China. Electronic address:

Nanosecond pulsed electric field (nsPEF) has the ability to induce a host of intracellular biochemical processes in living cells as a function of parameter setting. In vitro experiments proved that nsPEF stimulation could remarkably promote biomineralization processes and new bone formation. However, the impact of nsPEF parameter settings on the calcium flux of osteoblasts, as well as the intracellular mechanisms underlying those observations have yet to be elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675394173046
Publisher Site
http://dx.doi.org/10.1016/j.bioelechem.2018.06.009DOI Listing
December 2018
9 Reads

[Ten questions about constrictive pericarditis].

Authors:
Massimo Imazio

G Ital Cardiol (Rome) 2018 Jul-Aug;19(7):412-419

Cardiologia, AOU Città della Salute e della Scienza di Torino, Torino.

Constrictive pericarditis is one of the most feared complications of patients with pericarditis, especially if recurrent. The common perception is that the higher the number of recurrences, the higher the risk of constriction. However, the risk of constriction is related to the etiology and not to the number of recurrences. Read More

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http://dx.doi.org/10.1714/2938.29537DOI Listing
July 2018
10 Reads

Endovascular repair of severe aortic coarctation, transcatheter aortic valve replacement for severe aortic stenosis, and percutaneous coronary intervention in an elderly patient with long term follow-up.

J Saudi Heart Assoc 2018 Jul 9;30(3):271-275. Epub 2018 Feb 9.

Madina Cardiac Center, Adult cardiology, Madinah, Saudi ArabiaaSaudi Arabia.

To the best of our knowledge, there have not been any reports of total transcatheter approach including stenting of severe coarctation of the aorta (CoA), transcatheter aortic valve replacement (TAVR) for concomitant severe aortic valve stenosis, and percutaneous coronary intervention (PCI) to treat significant coronary artery disease in a single patient. We report a 70-year-old female, who presented with uncontrolled hypertension and acute decompensated heart failure (ADHF) and was found to have severe CoA, severe bicuspid aortic valve (BAV) stenosis, and significant proximal left anterior descending (LAD) coronary artery disease. In a multidisciplinary heart team meeting, we decided to perform an endovascular repair of both cardiac and vascular pathologies using a two-stage approach due to the significant comorbidities; mainly uncontrolled hypertension, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and severe calcifications of the ascending aorta. Read More

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http://dx.doi.org/10.1016/j.jsha.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035482PMC
July 2018
11 Reads

A case report of pediatric calciphylaxis-a rare and potentially fatal under diagnosed condition.

Medicine (Baltimore) 2018 Jul;97(27):e11300

University of Medicine and Pharmacy Grigore T. Popa Iasi.

Rationale: Though to be rare, calcific uremic arteriolophathy (CUA) is an ectopic calcification entity causing pain and disabilities in patients with chronic renal insufficiency, thus increasing the morbidity and mortality.

Patient Concern: We report a case of four years old boy admitted with acute respiratory failure. Physical examination revealed: irritability, purple subcutaneous hard nodules, tachypnea, dry spasmodic cough, respiratory rate 45/min, heart rate 110/min, blood pressure 100/60 mmHg, with normal heart sounds, no murmurs, hepatomegaly with hepato-jugular reflux. Read More

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http://dx.doi.org/10.1097/MD.0000000000011300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076114PMC
July 2018
5 Reads

Sheep models for evaluation of novel patch and prosthesis material in vascular surgery: tips and tricks to avoid possible pitfalls.

Acta Vet Scand 2018 Jul 5;60(1):42. Epub 2018 Jul 5.

Institute for Laboratory Animal Science, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

Background: In vascular surgery, novel synthetic prosthesis materials for patch-angioplasties, interpositions, bypasses and shunts are continuously under development and optimization. The characteristics of an ideal vascular prosthesis would display long-term patency, biocompatibility, durability, low porosity, lack of stich hole bleeding, ease of handling, kink resistance, infection resistance and reasonable costs. The aim of this study was to establish and report a reliable sheep model including potential pitfalls where those parameters could be analyzed. Read More

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http://dx.doi.org/10.1186/s13028-018-0397-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034312PMC
July 2018
11 Reads

Carotid calcifications in panoramic radiographs are associated with future stroke or ischemic heart diseases: a long-term follow-up study.

Clin Oral Investig 2018 Jul 2. Epub 2018 Jul 2.

University of Kristianstad, Elmetorpsvägen 15, 291 88, Kristianstad, Sweden.

Objective: To assess if carotid calcifications detected in panoramic radiographs are associated with future events of stroke, and/or ischemic heart diseases over 10-13 years in individuals between 60 and 96 years.

Materials And Methods: Baseline (2001-2004) panoramic radiographs were assessed for evidence of carotid calcifications from individuals with no previous history of stroke and/or ischemic heart diseases. A radiopaque nodular mass adjacent to the cervical vertebrae, at or below the intervertebral space C3-C4, was interpreted as carotid calcification. Read More

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http://dx.doi.org/10.1007/s00784-018-2533-8DOI Listing
July 2018
2 Reads

Value of mitral annular plane systolic excursion in the assessment of contractile reserve in patients with ischemic cardiomyopathy before cardiac revascularization.

Indian Heart J 2018 May - Jun;70(3):373-378. Epub 2017 Nov 6.

Cardiology department, Faculty of medicine, Alexandria University, Egypt.

Background: Mitral annular plane systolic excursion (MAPSE) is an M-mode derived echocardiographic marker of left ventricular longitudinal function, the aim of this study is to evaluate the value of MAPSE in assessment of contractile reserve in patients with ischemic cardiomyopathy before cardiac revascularization.

Methods: The study included 50 patients with ischemic cardiomyopathy with ejection fraction (EF) ≤35%, the patients presented to echocardiography laboratory for dobutamine stress echocardiography (DSE) to assess viability and contractile reserve before revascularization, patients with primary valvular disease, and those with significant mitral annular calcifications were excluded from the study. A low dose DSE was done to all patients using standardized incremental infusions of 5, 10, and 20 μg/kg/min and the following parameters were measured at both baseline and peak dose, (EF, wall motion score index(WMSI) and MAPSE). Read More

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http://dx.doi.org/10.1016/j.ihj.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034018PMC
September 2018

Commonly available hematological biomarkers are associated with the extent of coronary calcifications.

Atherosclerosis 2018 Aug 12;275:166-173. Epub 2018 Jun 12.

Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.

Background And Aims: We aimed to improve the understanding of potential associations between commonly available hematological biomarkers and the coronary artery calcification (CAC) score, which may help unravel the pathophysiology of coronary calcifications and subclinical coronary artery disease.

Methods: A cross-sectional study was performed within the Utrecht Patient Oriented Database (UPOD). Patients with suspected or known coronary artery disease who underwent CT CAC scoring as well as standard hematology analysis that was part of routine clinical care (within 3 months of CT acquisition) were included. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.017DOI Listing
August 2018
11 Reads

Acute myocardial infarction after blunt chest wall trauma with underlying coronary aneurysm: a case report.

BMC Cardiovasc Disord 2018 06 18;18(1):118. Epub 2018 Jun 18.

Department of Cardiology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping district, Shenyang City, Liaoning Province, 110004, People's Republic of China.

Background: Kawasaki disease is an acute febrile disease with mucocutaneous and cardiovascular involvement affecting infants and young children. Though coronary artery abnormalities are common in Kawasaki disease, no consensus has been reached regarding the treatment of acute coronary artery diseases in this population.

Case Presentation: We described a case of myocardial infarction triggered by blunt chest wall trauma in a 20 years old girl. Read More

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http://dx.doi.org/10.1186/s12872-018-0861-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006860PMC
June 2018
16 Reads