1,976 results match your criteria Cardiac Calcifications


Changes of the Heart Valves in the Long Term After Chemoradiotherapy According to Different Protocols for Hodgkin's Lymphoma in Children and Adolescents.

J Adolesc Young Adult Oncol 2019 Apr 24. Epub 2019 Apr 24.

1 Medical Institute of Russian Peoples Friendship University (RUDN University), Moscow, Russia.

The purpose of our work was to study late cardiac complications after treatment for Hodgkin's lymphoma (HL) in children and adolescents. Sixty-seven patients were examined in the long term (>5 years) after chemoradiotherapy for HL according to two different programs of treatment (groups I and II). Mean total doses of radiotherapy (RT) to the mediastinum were 37. Read More

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http://dx.doi.org/10.1089/jayao.2018.0142DOI Listing

Postinfarction Myocardial Calcifications on Cardiac Computed Tomography.

Circ Arrhythm Electrophysiol 2019 May;12(5):e007023

Division of Cardiovascular Medicine (D.M.A., K.C.S., G.S.D., M.Y., M.N., F.M., F.B.), University of Michigan, Ann Arbor.

Background: Postinfarction ventricular tachycardia (VT) generally involves myocardial fibers surrounded by scar. Calcification of scar tissue has been described, but the relationship between calcifications within endocardial scar and VTs is unclear. The purpose of this study was to assess the prevalence of myocardial calcifications as detected by cardiac computed tomography (CT) and the benefit for mapping and ablation focusing on nontolerated VTs. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.007023DOI Listing

Procedural and follow-up clinical outcomes after chronic total occlusion revascularization: Data from an Indian public hospital.

Indian Heart J 2019 Jan - Feb;71(1):65-73. Epub 2019 Jan 26.

Department of Cardiology, Jawaharlal Institute of Post Graduate Medical Education and Research(JIPMER), Puducherry, 605006, India.

Background: Chronic total occlusion (CTO) continues to be challenging lesion subset for percutaneous intervention. Last decade has seen tremendous increase in percutaneous coronary intervention (PCI) in this subset owing to improved understanding of the anatomy and enhanced skillset with availability of dedicated hardware. We sought to study the outcomes of CTO PCI in an Indian public hospital. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.12.003DOI Listing
January 2019
1 Read

Unexpected massive pleural effusion leading to discovery of left subclavian artery rupture during transcatheter aortic valve implantation.

J Cardiol Cases 2019 Apr 13;19(4):136-139. Epub 2019 Feb 13.

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

An 89-year-old woman underwent transcatheter aortic valve implantation (TAVI) for severe aortic valve stenosis, based on a logistic European System for Cardiac Operative Risk Evaluation of 59.6% and Society of Thoracic Surgeons risk score of 17.1%. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451059PMC
April 2019
1 Read

Contegra versus pulmonary homograft for right ventricular outflow tract reconstruction in newborns.

Cardiol Young 2019 Apr 3:1-6. Epub 2019 Apr 3.

Department of Cardiac Surgery, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF),Université Libre de Bruxelles,Brussels,Belgium.

Objectives: Pulmonary homografts are standard alternatives to right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately, shortage and conduit failure by early calcifications and shrinking are observed for small-sized homografts in younger patients. In neonates, Contegra® 12 mm (Medtronic Inc. Read More

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http://dx.doi.org/10.1017/S1047951119000143DOI Listing

Endobronchial ultrasound-guided transbronchial needle aspiration in sarcoidosis: Beyond the diagnostic yield.

Respirology 2019 Mar 25. Epub 2019 Mar 25.

Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, USA.

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the commonly used technique for pathological confirmation of clinically suspected sarcoidosis, mostly owing to its consistently high success rate in the detection of granulomas. However, other possible advantages, which are less appreciated and often poorly studied, may also contribute to the wider use of EBUS-TBNA in the future. These advantages include refinement of differential diagnoses through the study of lymph node characteristics during B-mode examination; reduction of complications associated with bronchoscopy, as well as improved triage of the specimen for ancillary studies with the use of rapid on-site evaluation; optimization of the quality of the sample through the selection of a target area for biopsy with minimal vascularity and absence of calcifications by using the colour Doppler and the B-mode; and prediction of the presence of extensive lymph node fibrosis by using the strain elastography module. Read More

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http://dx.doi.org/10.1111/resp.13537DOI Listing
March 2019
2 Reads

Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair.

Cardiovasc Pathol 2019 Feb 28;40:59-64. Epub 2019 Feb 28.

Children's Heart Centre, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czech Republic.

Objectives: The purpose of this study was to evaluate the microscopic structural abnormalities of the ascending aorta in infants with Tetralogy of Fallot (ToF) and compare them with aortic samples from control group of small children that died of other diseases. We aimed at identification of the specific histopathological changes associated with ToF and correlation of the severity of these changes with time to surgery and mean levels of saturation in the ToF group, and age at death in control group.

Methods: The full-thickness ascending aortic wall sample was taken from 23 children with ToF at the time of surgical reconstruction (age spread 2 to 19 months) and evaluated by light microscopy. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.02.004DOI Listing
February 2019
1 Read

A patient-specific mass-spring model for biomechanical simulation of aortic root tissue during transcatheter aortic valve implantation.

Phys Med Biol 2019 Apr 10;64(8):085014. Epub 2019 Apr 10.

Department of Industrial Engineering, University of Trento, Trento, Italy. Department of Physics, University of Trento, Trento, Italy.

The success of transcatheter aortic valve implantation (TAVI) is highly dependent on the prediction of the interaction between the prosthesis and the aortic root anatomy. The simulation of the surgical procedure may be useful to guide artificial valve selection and delivery, nevertheless the introduction of simulation models into the clinical workflow is often hindered by model complexity and computational burden. To address this point, we introduced a patient-specific mass-spring model (MSM) with viscous damping, as a good trade-off between simulation accuracy and time-efficiency. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab10c1
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http://dx.doi.org/10.1088/1361-6560/ab10c1DOI Listing
April 2019
4 Reads

Complete resection of a giant calcifying fibrous tumor of myocardial origin.

Gen Thorac Cardiovasc Surg 2019 Mar 9. Epub 2019 Mar 9.

Department of Cardiac Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

A calcifying fibrous tumor (CFT) is a rare, benign tumor that commonly develops in the internal viscera. It is histologically characterized by hyalinized collagenous tissue with calcifications and lymphoplasmacytic infiltrates. There have been few reports of CFTs occurring in the heart. Read More

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http://dx.doi.org/10.1007/s11748-019-01103-9DOI Listing

Cardiac calcification as a marker of subclinical atherosclerosis and predictor of cardiovascular events: A review of the evidence.

Eur J Prev Cardiol 2019 Mar 7:2047487319830485. Epub 2019 Mar 7.

7 Heart and Vascular Institute, Einstein Medical Center, Philadelphia, USA.

Risk prediction of future atherothrombotic cardiovascular events is currently based on conventional risk factor assessment and the use of validated algorithms, such as the Framingham Risk Score, the Pooled Cohort Equations, and the European SCORE Risk Charts. However, the identification of subclinical organ damage has emerged as a potentially more accurate predictor of individual risk. Several imaging modalities have been proposed for identification of preclinical atherosclerosis. Read More

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http://dx.doi.org/10.1177/2047487319830485DOI Listing
March 2019
1 Read

Predictive value of coronary calcifications for future cardiac events in asymptomatic patients: underestimation of risk in asymptomatic smokers.

Int J Cardiovasc Imaging 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiology, Ludwig-Maximilians-University Munich, Munich, Germany.

Coronary calcification (CAC) is an established marker for coronary atherosclerosis and has a highly specific predictive value for cardiovascular events. This study aimed to determine the predictive value in the specific group of asymptomatic smokers in comparison to non-smokers. We included 1432 asymptomatic individuals (575 women, 857 men, age 59. Read More

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http://dx.doi.org/10.1007/s10554-019-01571-3DOI Listing
March 2019
1 Read

Relationship of exercise to coronary artery disease extent, severity and plaque type: A coronary computed tomography angiography study.

J Cardiovasc Comput Tomogr 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine III, Cardiology, Innsbruck Medical University, Austria. Electronic address:

Background: While exercise has been associated with favorable coronary artery disease (CAD) outcomes, the relationship between endurance exercise levels and CAD findings has not been well explored.

Purpose: To evaluate the relationship of endurance exercise to CAD findings by coronary computed tomographic angiography (CCTA).

Methods: We evaluated consecutive patients referred to CCTA who filled out a survey instrument between 2015 and 2017, and who graded their level of weekly endurance exercise as: none, low (1-2 times per week), moderate (3-5 times per week) or high (5-7 times per week); along with the number of hours per week engaged in exercise as: low (<30 min), moderate (1 h) or high (>1-3 h). Read More

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http://dx.doi.org/10.1016/j.jcct.2019.02.001DOI Listing
February 2019

Significant mitral regurgitation in patients undergoing TAVR: Mechanisms and imaging variables associated with improvement.

Echocardiography 2019 04 4;36(4):722-731. Epub 2019 Mar 4.

Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval, Québec City, Québec, Canada.

Background: Significant mitral regurgitation (MR) is associated with poorer outcomes in patients undergoing transcatheter aortic valve replacement (TAVR). Factors associated with MR improvement have not been studied thoroughly.

Methods: Retrospective analysis of consecutive patients treated with TAVR with more than mild MR at baseline. Read More

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http://dx.doi.org/10.1111/echo.14303DOI Listing
April 2019
1 Read

Noncontrast Chest Computed Tomographic Imaging of Obesity and the Metabolic Syndrome: Part I Cardiovascular Findings.

J Thorac Imaging 2019 Mar;34(2):116-125

Department of Radiology, University of Wisconsin-Madison, Madison, WI.

There are physiological consequences of overeating that can lead to increased morbidity and mortality. The purpose of this review article is to acquaint the reader with the current state of the art in the non-cardiac-gated, noncontrast chest computed tomographic (NCCT) imaging biomarkers of the metabolic syndrome and their prognostic significance found in the lower neck and chest. NCCT imaging biomarkers associated with metabolic syndrome in the chest include premature coronary artery calcification, acceleration of large vessel arterial and valvular calcifications associated with atherosclerosis, and pulmonary arterial enlargement from pulmonary hypertension associated with sleep apnea. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000391DOI Listing
March 2019
12 Reads

Noncontrast Chest Computed Tomographic Imaging of Obesity and the Metabolic Syndrome: Part I Cardiovascular Findings.

J Thorac Imaging 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, University of Wisconsin-Madison, Madison, WI.

There are physiological consequences of overeating that can lead to increased morbidity and mortality. The purpose of this review article is to acquaint the reader with the current state of the art in the non-cardiac-gated, noncontrast chest computed tomographic (NCCT) imaging biomarkers of the metabolic syndrome and their prognostic significance found in the lower neck and chest. NCCT imaging biomarkers associated with metabolic syndrome in the chest include premature coronary artery calcification, acceleration of large vessel arterial and valvular calcifications associated with atherosclerosis, and pulmonary arterial enlargement from pulmonary hypertension associated with sleep apnea. Read More

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http://Insights.ovid.com/crossref?an=00005382-201903000-0000
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http://dx.doi.org/10.1097/RTI.0000000000000391DOI Listing
February 2019
5 Reads

A Review of the Role of Breast Arterial Calcification for Cardiovascular Risk Stratification in Women.

Circulation 2019 Feb;139(8):1094-1101

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego.

Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038092DOI Listing
February 2019
2 Reads

Iatrogenic embolization following cardiac intervention: postmortem analysis of 110 cases.

Cardiovasc Pathol 2019 Jan 19;40:12-18. Epub 2019 Jan 19.

University of British Columbia, Pathology & Laboratory Medicine, Vancouver, BC, Canada; Vancouver General Hospital, Neuropathology, Vancouver, BC, Canada; St. Paul's Hospital, Pathology & Laboratory Medicine, Vancouver, BC, Canada. Electronic address:

Introduction: Iatrogenic embolization following cardiac investigative procedures may result from hydrophilic polymer emboli (HPE) from catheter valve and vessel wall calcifications, and air embolism from open heart surgery. This retrospective clinical pathologic analysis was undertaken to ascertain the frequency and extent of these potentially fatal complications.

Methods: This retrospective clinical pathologic autopsy analysis with premortem diagnostic imaging correlation identified 110 individuals who had undergone endovascular procedures between 2010 and 2016 within 90 days of death and followed by hospital autopsy. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.01.003DOI Listing
January 2019
2 Reads

Cardiovascular findings on cross-sectional imaging: spectrum of incidental and critical findings and clinical relevance for the abdominal radiologist.

Abdom Radiol (NY) 2019 Mar;44(3):1161-1180

Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Although not the primary focus of the exams, cardiovascular structures are included to some extent on all abdominal or whole-body cross-sectional studies. Cardiovascular findings often present incidentally and may range from chronic to acute and emergent pathologies. Among the most common cardiovascular findings are the presence of cardiac calcifications, most commonly coronary, which correlate with the presence of coronary artery and valvular disease. Read More

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http://dx.doi.org/10.1007/s00261-019-01922-7DOI Listing

Sex differences in coronary artery plaque composition detected by coronary computed tomography: quantitative and qualitative analysis.

Neth Heart J 2019 May;27(5):272-280

Department of Radiology, Innsbruck Medical University, Innsbruck, Austria.

Background: Sex differences in the calculation of coronary heart disease risk have been analysed extensively. However, data on coronary plaque morphology diverge. We analysed plaque characteristics in patients with suspected coronary artery disease (CAD) and defined prognostic factors using coronary computed tomography angiography (CCTA). Read More

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http://dx.doi.org/10.1007/s12471-019-1234-5DOI Listing
May 2019
1 Read

The novel inflammatory marker GlycA and the prevalence and progression of valvular and thoracic aortic calcification: The Multi-Ethnic Study of Atherosclerosis.

Atherosclerosis 2019 Mar 24;282:91-99. Epub 2019 Jan 24.

The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Background And Aims: GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with coronary artery calcium, cardiovascular disease (CVD) events and mortality. Vascular calcifications outside of the coronary arteries are risk markers of CVD and mortality. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401213PMC
March 2019
2 Reads

Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet.

Front Cardiovasc Med 2018 18;5:196. Epub 2019 Jan 18.

UMR 7365 CNRS-Université de Lorraine, IMoPA, Vandoeuvre-lès-Nancy, France.

The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed light on the consequences of loss-of-function mutations for different calcification inhibitors, and genetic targeting of these pathways in mice have generated a clearer picture on the mechanisms involved. For example, generalized arterial calcification of infancy (GACI) is caused by mutations in the enzyme ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (eNPP1), preventing the hydrolysis of ATP into pyrophosphate (PP). Read More

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http://dx.doi.org/10.3389/fcvm.2018.00196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345677PMC
January 2019
1 Read

Comparison of Nongated Chest CT and Dedicated Calcium Scoring CT for Coronary Calcium Quantification Using a 256-Dector Row CT Scanner.

Acad Radiol 2019 Jan 23. Epub 2019 Jan 23.

Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China; Department of Radiology, Affiliated Hospital of Shaanxi Chinese Medicine University, Xianyang 712000, China. Electronic address:

Background: Coronary artery calcification (CAC) is a marker of atherosclerosis and an independent risk factor for cardiac-related mortality and frequently detected on noncontrast chest CT. We aimed to investigate the reliability and accuracy of determining CAC using noncontrast, nongated chest CT with 256-detector row.

Materials And Methods: A total of 1318 patients for chest examination were enrolled to undergo both nongated chest CT and dedicated calcium-scoring CT (CSCT) on a 256-detector row CT scanner. Read More

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http://dx.doi.org/10.1016/j.acra.2018.12.005DOI Listing
January 2019
3 Reads

[Molecular mechanism of vascular calcification.]

Clin Calcium 2019;29(2):157-163

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Intimal and medial calcification are increased with type 1 and type 2 diabetes, metabolic syndrome, chronic kidney disease, and ageing. There are several biological mechanisms through which vascular calcification increases all-cause mortality and atherosclerotic plaque rupture. Arterial medial calcification increases arterial stiffness that causes systolic hypertension and diastolic dysfunction and heart failure. Read More

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http://dx.doi.org/10.20837/4201902157DOI Listing
January 2019
11 Reads

Clinical presentation and management of hypoparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 12 28;32(6):927-939. Epub 2018 Sep 28.

Department of Surgery and Translational Medicine, University of Florence, Bone Metabolic Diseases Unit, University Hospital of Florence, Italy. Electronic address:

The clinical manifestations of hypoparathyroidism are variable and can involve almost any organ system. The main clinical features of the hypoparathyroidism are typically signs or symptoms due to neuromuscular irritability owing to low serum calcium level. In addition to hypocalcemia, hyperphosphatemia can contribute to long-term complications, including extra-skeletal calcifications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183010
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http://dx.doi.org/10.1016/j.beem.2018.09.007DOI Listing
December 2018
9 Reads

Sex Differences in Coronary Artery and Thoracic Aorta Calcification and Their Association With Cardiovascular Mortality in Heavy Smokers.

JACC Cardiovasc Imaging 2019 Jan 16. Epub 2019 Jan 16.

Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.

Objectives: The aim of this study was to investigate sex differences in the prevalence, extent, and association of coronary artery calcium (CAC) and thoracic aorta calcium (TAC) scores with cardiovascular mortality in a population eligible for lung screening.

Background: CAC and TAC scores derived from chest computed tomography (CT) might be useful biomarkers for individualized cardiovascular disease prevention and could be especially relevant in high-risk populations such as heavy smokers. Therefore, it is important to know the prevalence of arterial calcifications in male and female heavy smokers, and if there are differences in the predictive value calcifications carry. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.026DOI Listing
January 2019
3 Reads

Risk factors for atrioventricular block after transcatheter aortic valve implantation: a single-centre analysis including assessment of aortic calcifications and follow-up.

Europace 2019 Jan 9. Epub 2019 Jan 9.

Department of Cardiac Surgery, Cardiovascular Center, Klinikum Nürnberg - Paracelsus Medical University, Breslauer Str. 201, Nuremberg, Germany.

Aims: To assess the contribution of aortic valve calcification to the occurrence of transient or permanent atrioventricular block (AVB) and the need for permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) in a large single-centre cohort.

Methods And Results: We retrospectively analysed pre-operative contrast-enhanced multidetector computed tomography scans of patients who underwent TAVI in our centre between 2012 and 2016. Calcium volume was calculated for each aortic cusp above (aortic valve), and below [left ventricular outflow tract (LVOT)] the basal plane. Read More

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http://dx.doi.org/10.1093/europace/euy316DOI Listing
January 2019
16 Reads

Emerging role of myostatin and its inhibition in the setting of chronic kidney disease.

Kidney Int 2019 Mar 28;95(3):506-517. Epub 2018 Dec 28.

Department of Nephrology and Nutrition, Centre Hospitalier Lyon SUD, Carmen, CENS, University of Lyon, UCBL, Pierre Bénite, France.

The past two decades have witnessed tremendous progress in our understanding of the mechanisms underlying wasting and cachexia in chronic kidney disease (CKD) and in other chronic illnesses, such as cancer and heart failure. In all these conditions wasting is an effect of the activation of protein degradation in muscle, a response that increases the risk of morbidity and mortality. Major recent advances in our knowledge on how CKD and inflammation affect cellular signaling include the identification of the myostatin (MSTN)/activin system, and its related transcriptional program that promotes protein degradation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183077
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http://dx.doi.org/10.1016/j.kint.2018.10.010DOI Listing
March 2019
14 Reads

Microsurgical clipping of a large ruptured anterior communicating artery aneurysm.

Surg Neurol Int 2018 28;9:233. Epub 2018 Nov 28.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Anterior communicating artery (AComA) aneurysms are the most complex aneurysms of the anterior cerebral circulation. They mostly arise between the dominant A1 and the AComA, and are associated with intraventricular hemorrhage or other aneurysms in around 20%-30% of the cases. Giant and fusiform aneurysms are rare in this location in contrast to the common small ruptured aneurysms. Read More

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http://dx.doi.org/10.4103/sni.sni_345_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287331PMC
November 2018
2 Reads

Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images.

PLoS One 2018 20;13(12):e0209318. Epub 2018 Dec 20.

Image Sciences Institute, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.

Introduction: The amount of coronary artery calcium determined in CT scans is a well established predictor of cardiovascular events. However, high interscan variability of coronary calcium quantification may lead to incorrect cardiovascular risk assignment. Partial volume effect contributes to high interscan variability. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209318PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301689PMC
December 2018
10 Reads

Agatston score of the descending aorta is independently associated with coronary events in a low-risk population.

Open Heart 2018 24;5(2):e000893. Epub 2018 Nov 24.

Department of Cardiology, Maastricht University Medical Center (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.

Objectives: A standard coronary artery calcium scan includes part of the aorta. This additional information is often not included in routine analyses. We aimed to determine the feasibility of assessing the Agatston score of the descending aorta calcification (DAC) on standard coronary calcium scans and the association of this score with coronary events in a low-risk study population. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269642PMC
November 2018
1 Read

Histopathologic Characterization of Peripheral Arteries in Subjects With Abundant Risk Factors: Correlating Imaging With Pathology.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

CVPath Institute, Gaithersburg, Maryland.

Objectives: The aim of this study was to comprehensively evaluate the pathology of the lower extremity arteries across their entire length in subjects dying with abundant risk factors and to evaluate the clinical and imaging implications of the pathological characteristics.

Background: Lower extremity peripheral arterial disease is a major cause of cardiovascular morbidity, but a systematic characterization of the pathology has never been undertaken.

Methods: Twelve legs were obtained from 8 cadavers with histories of coronary risk factors (median age 82 years, 6 men); 8 of 12 legs were evaluated using computed tomography before the major peripheral arteries were dissected along their entire length. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.08.039DOI Listing
December 2018
6 Reads

Human native endocarditis caused by Streptococcus canis-a case report.

APMIS 2019 Jan;127(1):41-44

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.

We report a very rare case of Streptococcus canis native infective endocarditis in a 73-year-old woman living in close contact with her dog. Her echocardiography showed large calcifications in the mitral annulus, massive regurgitation below the posterior leaflet, and adjacent vegetation. Blood culture was positive for Streptococcus Lancefield group G. Read More

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http://dx.doi.org/10.1111/apm.12905DOI Listing
January 2019
3 Reads

New radiological findings and radiculomegaly in oculofaciocardiodental syndrome with a novel BCOR mutation: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13444

Chairman Emeritus, Kushima Orthodontic Clinic, Abeno, Osaka, Japan.

Rationale: Oculofaciocardiodental syndrome (OFCD) patients who show radiculomegaly are very rare. We treated a new OFCD patient orthodontically, and performed longitudinal observation for 30 years. New findings, termed calcified-dental-papillae (CDPs) beneath open-apices (OAs) of developing radiculomegalies, pulp-stone-like-calcifications (PSLCs) and the process of radiculomegaly development were observed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310535PMC
December 2018
1 Read

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor.

Int J Cardiol 2019 Mar 29;278:243-249. Epub 2018 Nov 29.

Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

Aims: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.11.119DOI Listing
March 2019
5 Reads

Usefulness of the Echocardiographic Calcium Score to Refine Risk of Major Adverse Cardiovascular Events Beyond the Traditional Framingham Risk Score.

Am J Cardiol 2019 Feb 19;123(3):392-395. Epub 2018 Oct 19.

Albert Einstein Medical Center, Division of Cardiology, Philadelphia, Pennsylvania.

Echocardiographic calcifications are associated with major adverse cardiovascular events (MACE). A recently described semiquantitative Global Cardiac Calcium Score (GCCS) has been associated with mortality and stroke, with increasing scores associated with increasing risk. This score assigns points for calcium in the aortic root and valve, mitral valve and annulus, and submitral apparatus, with additional points for restricted leaflet mobility. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.10.009DOI Listing
February 2019
1 Read

Rotational atherectomy in everyday clinical practice. Association of Cardiovascular Interventions of the Polish Society of Cardiology (Asocjacja Interwencji Sercowo-Naczyniowych Polskiego Towarzystwa Kardiologicznego - AISN PTK): Expert opinion.

Kardiol Pol 2018;76(11):1576-1584

The common use of stents, including antiproliferative drug-eluting stents, has been a major breakthrough in invasive cardiology. Nowadays, a change in the clinical presentation of patients treated with percutaneous coronary intervention (PCI) is observed. The typical clinical characteristics now include advanced age, diabetes, chronic kidney disease, heart failure, and multilevel atherosclerosis. Read More

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http://dx.doi.org/10.5603/KP.2018.0225DOI Listing
March 2019
1 Read

Complementary Role of the Computed Biomodelling through Finite Element Analysis and Computed Tomography for Diagnosis of Transcatheter Heart Valve Thrombosis.

Biomed Res Int 2018 22;2018:1346308. Epub 2018 Oct 22.

Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy.

Introduction: The TAVR procedure is associated with a substantial risk of thrombosis. Current guidelines recommend catheter-based aortic valve implantation for prohibitive-high-risk patients with severe aortic valve stenosis but acknowledge that the aetiology and mechanism of thrombosis are unclear.

Methods: From 2015 to 2018, 607 patients with severe aortic valve stenosis underwent either self-expandable or balloon-expandable catheter-based aortic valve implantation at our institute. Read More

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https://www.hindawi.com/journals/bmri/2018/1346308/
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http://dx.doi.org/10.1155/2018/1346308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217904PMC
February 2019
16 Reads

Suspected Pericardial Tuberculosis Revealed as an Amyloid Pericardial Mass.

Case Rep Hematol 2018 17;2018:8606430. Epub 2018 Oct 17.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine "G. Baccelli", University of Bari Aldo Moro Medical School, Bari, Italy.

Primary systemic amyloidosis is not easily diagnosed. The immunoglobulin deposits are usually localized in the kidney, heart, and liver. We describe an unusual case of a patient suffering from a pericardial amyloidoma with internal calcifications and air bubbles that compressed the right ventricle and shifted the heart to the left. Read More

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https://www.hindawi.com/journals/crihem/2018/8606430/
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http://dx.doi.org/10.1155/2018/8606430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207883PMC
October 2018
20 Reads

The effect of heparin hydrogel embedding on glutaraldehyde fixed bovine pericardial tissues: Mechanical behavior and anticalcification potential.

J Mater Sci Mater Med 2018 Nov 9;29(11):175. Epub 2018 Nov 9.

Department of Mechanical Engineering and Aeronautics, Laboratory of Biomechanics & Biomedical Engineering, University of Patras, Patras, Greece.

Heart valve diseases remain common in industrialized countries. Bioprosthetic heart valves, introduced as free of anticoagulation therapy alternatives to mechanical substitutes. Still they suffer from long term failure due to calcification. Read More

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http://link.springer.com/10.1007/s10856-018-6184-8
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http://dx.doi.org/10.1007/s10856-018-6184-8DOI Listing
November 2018
9 Reads

[Calcific uremic arteriolopathy in hemodialysis patient, review of literature through five cases reports].

Nephrol Ther 2018 Nov 29;14(6):439-445. Epub 2018 Jun 29.

Service de néphrologie-hémodialyse et transplantation rénale, université Cadi Ayyad, CHU Mohammed VI, BP 2360 Principal, avenue Ibn Sina, Marrakech, Maroc.

Calcific uremic arteriolopathy, also called calciphylaxis, is a rare and severe disorder that presents with skin ischemia and necrosis, sometimes it presents with systemic necrosis, the process is secondary to the obliteration of the arterioles first by sub-intimal calcium deposits and then by thrombosis. These lesions can often lead to death due to infectious complications and comorbidities such as diabetes, obesity, arteritis, diffuse vascular calcifications, heart disease and undernutrition. The diagnosis is suggested by the characteristic ischemic skin lesions and their distribution, often bilateral and painful, associeted with calcific uremic arteriolopathy risk factors (phosphocalcic abnormalities, anti-vitamin K). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183013
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http://dx.doi.org/10.1016/j.nephro.2018.04.004DOI Listing
November 2018
13 Reads

Prognostic Value of Vascular Calcifications and Regional Fat Depots Derived From Conventional Chest Computed Tomography.

J Thorac Imaging 2019 Jan;34(1):33-40

Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.

Purpose: The prognostic value of vascular calcifications as well as of regional fat depots has been reported separately, in population-based studies, and using gated-computed tomography (CT) examinations. We, therefore, explored the interplay and prognostic value of vascular calcifications and adipose tissue depots assessed during conventional nongated chest CT.

Materials And Methods: We enrolled a consecutive series of 1250 patients aged between 35 and 74 years who underwent clinically indicated chest CT scans. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000370DOI Listing
January 2019
8 Reads

An in vitro model quantifying the effect of calcification on the tissue-stent interaction in a stenosed aortic root.

J Biomech 2019 Jan 25;82:109-115. Epub 2018 Oct 25.

MMDRG, Biomechanics Research Centre, Biomedical Engineering, College of Engineering & Informatics, National University of Ireland Galway, Ireland. Electronic address:

Transcatheter Aortic Valves rely on the tissue-stent interaction to ensure that the valve is secured within the aortic root. Aortic stenosis presents with heavily calcified leaflets and it has been proposed that this calcification also acts to secure the valve, but this has never been quantified. In this study, we developed an in vitro calcified aortic root model to quantify the role of calcification on the tissue-stent interaction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219290183077
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http://dx.doi.org/10.1016/j.jbiomech.2018.10.010DOI Listing
January 2019
8 Reads

Effect of Virtual Monoenergetic Images From Spectral Detector Computed Tomography on Coronary Calcium Blooming.

J Comput Assist Tomogr 2018 Nov/Dec;42(6):912-918

Objective: The aim of this study was to investigate the quantitative and qualitative effects of virtual monoenergetic images (VMI) by spectral detector computed tomography (SDCT) on calcium blooming in coronary computed tomography angiography.

Methods: Coronary computed tomography angiography using SDCT was performed on 42 patients with coronary artery calcifications. Stenosis grading by diameter and area of calcified plaques and free lumen using VMI from 70 to 140 keV was performed and compared with measurements by conventional images. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000811DOI Listing
November 2018
10 Reads

Radiological findings of breast involvement in benign and malignant systemic diseases.

Radiol Bras 2018 Sep-Oct;51(5):328-333

Department of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.

Although the primary purpose of periodic mammograms in screening programs is to identify lesions suspected of being carcinomas, the findings are often related to systemic (benign or malignant) diseases, rather than breast cancer. Although the involvement of breast structures in systemic diseases is unusual, it can be included in the differential diagnosis of masses, skin changes, calcifications, asymmetry, and axillary lymphadenopathy. The main diagnostic entities that can be associated with such involvement are diabetes, chronic kidney disease, heart diseases, connective tissue diseases, HIV infection, lymphoma, leukemia, and metastases from primary tumors at other sites. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2016.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198842PMC
October 2018
5 Reads

Disparity in spatial distribution of pericardial calcifications in constrictive pericarditis.

Open Heart 2018 7;5(2):e000835. Epub 2018 Oct 7.

Center for the Diagnosis and Treatment of Pericardial Diseases, Cleveland Clinic, Heart and Vascular Institute, Cleveland, Ohio, USA.

Background: Pericardial calcification is seen among patients with constrictive pericarditis (CP). However, the pattern of pericardial calcium distribution and the association with clinical outcomes and imaging data are not well described.

Methods: This was a retrospective study from 2007 to 2013 to evaluate the pattern of pericardial calcium distribution by CT in CP using a semiquantitative calcium scoring system to calculate total pericardial calcium burden and distribution. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2018-000
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http://dx.doi.org/10.1136/openhrt-2018-000835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196947PMC
October 2018
17 Reads

Pre-procedural fit-testing of TAVR valves using parametric modeling and 3D printing.

J Cardiovasc Comput Tomogr 2019 Jan - Feb;13(1):21-30. Epub 2018 Oct 2.

Department of Radiology, University of Washington, USA; VA Puget Sound Health Care System, USA. Electronic address:

Background: Successful transcatheter aortic valve replacement (TAVR) requires an understanding of how a prosthetic valve will interact with a patient's anatomy in advance of surgical deployment. To improve this understanding, we developed a benchtop workflow that allows for testing of physical interactions between prosthetic valves and patient-specific aortic root anatomy, including calcified leaflets, prior to actual prosthetic valve placement.

Methods: This was a retrospective study of 30 patients who underwent TAVR at a single high volume center. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19345925183017
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http://dx.doi.org/10.1016/j.jcct.2018.09.007DOI Listing
March 2019
16 Reads

Acute peri-operative coronary subclavian steal syndrome: A diagnostic and treatment challenge.

J Cardiol Cases 2018 May 22;17(5):155-158. Epub 2018 Mar 22.

Department of Cardiac Surgery, University Hospital Lausanne (CHUV) + Cantonal Hospital Sion, Switzerland.

The coronary subclavian steal syndrome (CSSS) generally occurs during follow up after coronary surgery. The case demonstrates an immediate peri-operative CSSS followed by myocardial infarction, notwithstanding a preoperative computed tomography scan quantifying subclavian artery calcifications as non-stenosing, and a subjective patent blood flow through the transected left internal mammary artery (LIMA). Blood flow inversion in the LIMA to anterior descending artery (LAD) bypass was detected by transit time flow measurement (TTFM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409183000
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http://dx.doi.org/10.1016/j.jccase.2017.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149653PMC
May 2018
2 Reads

Bioresorbable vascular scaffold implantation for severely calcified lesions after excimer laser lesion preparation.

Catheter Cardiovasc Interv 2018 Dec 30;92(7):1283-1288. Epub 2018 Sep 30.

Unit of Cardiovascular Interventions, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Bioresorbable vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, CA) temporarily elute antiproliferative drugs and provide vessel support, which then subsequently resorb to allow restoration of normal vessel function and architecture. To attain the best possible results with BVS, a dedicated implantation technique (PSP: adequate lesion preparation, proper sizing, postdilatation) is considered mandatory, and calcified lesions are one of the most challenging lesion subsets for BVS implantation. In five cases with severe calcifications refractory to balloon predilatation, we performed excimer laser catheter ablation (ELCA: Turbo Elite catheter; Spectranetics Corporation, Colorado Springs, CO, USA), which facilitated adequate lesion expansion with high-pressure noncompliant balloon inflation and BVS implantation. Read More

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http://doi.wiley.com/10.1002/ccd.27704
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http://dx.doi.org/10.1002/ccd.27704DOI Listing
December 2018
17 Reads

Sodium-fluoride PET-CT for the non-invasive evaluation of coronary plaques in symptomatic patients with coronary artery disease: a cross-correlation study with intravascular ultrasound.

Eur J Nucl Med Mol Imaging 2018 11 31;45(12):2181-2189. Epub 2018 Aug 31.

Department of Nuclear Medicine, The First Hospital of Shanxi Medical University, Molecular Imaging Precision Medical Collaborative Innovation Center, Taiyuan, 030001, Shanxi Province, China.

Objectives: The aim of this study was to evaluate the F-sodium fluoride (F-NaF) coronary uptake compared to coronary intravascular ultrasound (IVUS) in patients with symptomatic coronary artery disease.

Background: F-NaF PET enables the assessment of vascular osteogenesis by interaction with surface hydroxyapatite, while IVUS enables both identification and quantification of intra-plaque components.

Methods: Forty-four patients with symptomatic coronary artery disease were included in this prospective controlled trial, 32 of them (30 patients with unstable angina and 2 patients with stable angina), representing the final study cohort, got additional IVUS. Read More

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http://dx.doi.org/10.1007/s00259-018-4122-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182395PMC
November 2018
6 Reads
5.380 Impact Factor

Automated Agatston Score Computation in non-ECG Gated CT Scans Using Deep Learning.

Proc SPIE Int Soc Opt Eng 2018 Feb 2;10574. Epub 2018 Mar 2.

Applied Chest Imaging Laboratory. Brigham and Women's Hospital. 1249 Boylston St. Boston. Massachusetts. United States.

Introduction: The Agatston score is a well-established metric of cardiovascular disease related to clinical outcomes. It is computed from CT scans by a) measuring the volume and intensity of the atherosclerotic plaques and b) aggregating such information in an index.

Objective: To generate a convolutional neural network that inputs a non-contrast chest CT scan and outputs the Agatston score associated with it directly, without a prior segmentation of Coronary Artery Calcifications (CAC). Read More

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https://www.spiedigitallibrary.org/conference-proceedings-of
Publisher Site
http://dx.doi.org/10.1117/12.2293681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095680PMC
February 2018
16 Reads