2,126 results match your criteria Cardiac Calcifications


Efficacy and Safety of Direct Factor Xa Inhibitors Versus Warfarin in Prevention of Primary and Secondary Ischemic Strokes in Non-Valvular Atrial Fibrillation: A Literature Review.

Cureus 2020 Jul 26;12(7):e9400. Epub 2020 Jul 26.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Ischemic stroke remains a major cause of mortality and morbidity in patients with atrial fibrillation. The use of appropriate anticoagulants reduces the risk of ischemic stroke in these patients. The current literature review is aimed to analyze the follow-up efficacy and safety of direct factor Xa inhibitors versus warfarin in the prevention of primary and secondary ischemic stroke, risk of major and minor bleedings, and food and drug interaction in patients with atrial fibrillation (AF). Read More

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http://dx.doi.org/10.7759/cureus.9400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386051PMC

Combined aortic valve and coronary artery calcifications in lung cancer screening as predictors of death from cardiovascular disease.

Eur Radiol 2020 Jul 28. Epub 2020 Jul 28.

Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

Objectives: Smoking is a major risk factor for both cardiovascular disease (CVD) and lung cancer. Aortic valve calcification (AVC) and coronary artery calcification (CAC) are both due to atherosclerotic disease. We aim to investigate whether AVC on low-dose CT (LDCT) predicts death from CVD in smokers beyond that provided by CAC. Read More

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http://dx.doi.org/10.1007/s00330-020-07049-4DOI Listing

Effect of embryo stage at transfer on placental histopathology features in singleton live births resulting from fresh embryo transfers.

Fertil Steril 2020 Jul 21. Epub 2020 Jul 21.

Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.

Objective: To evaluate the effect of embryo stage at transfer on placental histopathology and perinatal outcome in singleton live births resulting from fresh embryo transfers (ETs).

Design: Retrospective cohort study.

Setting: Not applicable. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.06.017DOI Listing

Possible Link Between the ABO Blood Group of Bioprosthesis Recipients and Specific Types of Structural Degeneration.

J Am Heart Assoc 2020 Aug 23;9(15):e015909. Epub 2020 Jul 23.

Biosurgical Research Lab (Carpentier Foundation) APHPGeorges PompidouEuropean Georges Pompidou Hospital Paris France.

Background Pigs/bovines share common antigens with humans: α-Gal, present in all pigs/bovines close to the human B-antigen; and AH-histo-blood-group antigen, identical to human AH-antigen and present only in some animals. We investigate the possible impact of patients' ABO blood group on bioprosthesis structural valve degeneration (SVD) through calcification/pannus/tears/perforations for patients ≤60 years at implantation. Methods and Results This was a single-center study (Paris, France) that included all degenerative bioprostheses explanted between 1985 and 1998, mostly porcine bioprostheses (Carpentier-Edwards second/third porcine bioprostheses) and some bovine bioprostheses. Read More

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http://dx.doi.org/10.1161/JAHA.119.015909DOI Listing

Metastatic Calcinosis of Gastric Mucosa.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620940482

Augusta University Medical Center, Medical College of Georgia, Augusta, GA, USA.

Calcinosis cutis refers to the deposition of calcium salts in the cutaneous and subcutaneous tissue and is frequently associated with inflammation. Gastric calcinosis can be classified into metastatic, dystrophic, and idiopathic; metastatic calcinosis is the most common type. In metastatic calcification, calcium salts are deposited in normal soft tissues in the setting of altered metabolism of serum calcium and phosphorus and is a rare and serious complication of chronic renal failure. Read More

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http://dx.doi.org/10.1177/2324709620940482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370329PMC

The Future of Concurrent Automated Coronary Artery Calcium Scoring on Screening Low-Dose Computed Tomography.

Cureus 2020 Jun 12;12(6):e8574. Epub 2020 Jun 12.

Radiology, Medical University of South Carolina, Charleston, USA.

Low-dose computed tomography (LDCT) has been extensively validated for lung cancer screening in selected patient populations. Additionally, the use of gated cardiac CT to assess coronary artery calcium (CAC) burden has been validated to determine a patient's risk for major cardiovascular adverse events. This is typically performed by calculating an Agatston score based on density and overall burden of calcified plaque within the coronary arteries. Read More

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http://dx.doi.org/10.7759/cureus.8574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358941PMC

The performance of non-ECG gated chest CT for cardiac assessment - The cardiac pathologies in chest CT (CaPaCT) study.

Eur J Radiol 2020 Jun 25;130:109151. Epub 2020 Jun 25.

Department of Diagnostic and Interventional Radiology, Helios Kliniken Duisburg, An Der Abtei 7-11, 47166 Duisburg, Germany. Electronic address:

Purpose: Evaluating the prevalence of CAD on non-ECG gated chest CTs, image quality (IQ) and the clinical performance of the CAD-RADS classification for predicting cardiovascular events (CVE).

Methods: 215 consecutive patients referred for chest CTs between May 2016 and March 2018 were included (3rd-generation DSCT) using non-ECG gated acquisitions with automated tube voltage selection (110kV/40mAs), pitch 2.65-3. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109151DOI Listing

Critical Cyanosis in a Neonate With Unusual Congenital Tricuspid Valve Lesion.

World J Pediatr Congenit Heart Surg 2020 Jul;11(4):504-506

Pediatric Cardiac Intensive Care Unit, National Heart Hospital, Sofia, Bulgaria.

We describe a case of a low birth weight neonate who presented on second day of life with progressive cyanosis and oxygen saturation of 60% by pulse oximetry. The echocardiography examination revealed a large tumor-like mass connected to the tricuspid valve, with severe obstruction of the right ventricular inflow and massive right-to-left shunt through the distended foramen ovale. A large vegetation-like lesion with calcifications was discovered intraoperatively and was debrided by shave excision technique under deep hypothermic circulatory arrest. Read More

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http://dx.doi.org/10.1177/2150135120904645DOI Listing

First report of a trifecta bioprosthesis sudden onset three leaflet detachment.

Ann Thorac Surg 2020 Jun 30. Epub 2020 Jun 30.

Cardiac Surgery Department, Hospital Universitario Moncloa. Madrid, Spain.

Acute bioprosthesis failure is an uncommon event that may require urgent surgery. This is even less frequent when it is not associated to endocarditis, thombus formation or structural valve deterioration. We describe for the first time an acute complete detachment of the three leaflets of a Trifecta tissue valve six years after the implantation, in a patient who suddenly suffered a strong chest pain with acute dyspnea. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.065DOI Listing

Valvular Damage.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S26-S32. Epub 2020 Apr 10.

Department of Heart, University Hospital of Salerno, Salerno, Italy.

Valvular heart diseases (VHD) may be observed in patients with cancer for several reasons, including preexisting valve lesions, radiotherapy, infective endocarditis, and secondary to the left ventricle dysfunction. The incidence of VHD is especially in younger survivors treated with thoracic radiation therapy for certain malignancies, such as Hodgkin's lymphoma and breast cancer. The mechanism of radiation-induced damage to heart valves is not clear and includes diffuse fibrocalcific thickening of the valve. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_5_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293871PMC

Neonatal lupus erythematosus presenting with rash, thrombocytopenia compounded by cytomegalovirus colonisation: a diagnostic dilemma.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Department of Pediatrics and Neonatology, Cloudnine Hospital, Gurgaon, Haryana, India.

Neonatal lupus erythematosus (NLE) should be considered when a newborn develops atrioventricular heart block along with the presence of autoantibodies to Sjogren's syndrome autoantigens in the maternal serum. NLE can also present with features such as cutaneous lesions, hepatic dysfunction or haematological abnormalities. Differential diagnosis usually includes congenital infections as there is a significant overlap of symptoms with NLE. Read More

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http://dx.doi.org/10.1136/bcr-2019-233873DOI Listing

Tricuspid valve calcification in familial pulmonary alveolar microlithiasis: A case report.

Ann Med Surg (Lond) 2020 Jul 30;55:256-259. Epub 2020 May 30.

Department of Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Pulmonary Alveolar Microlithiasis (PAM) is an uncommon, gradually progressive and eventually fatal hereditary disease that affects young population. Familial cases account for up to 50% of reported cases. There are few described cases of extrapulmonary manifestations of PAM and rare reports of cardiac involvement. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.05.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281303PMC

The role of stress concentration in calcified bicuspid aortic valve.

J R Soc Interface 2020 Jun 10;17(167):20190893. Epub 2020 Jun 10.

Tissue Mechanics Laboratory, The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the aging population, and is now believed to be a slow, progressive, yet actively regulated process. The disease progression can be divided into two phases: initiation phase associated with lipid deposition and inflammation response, and the later propagation phase with active calcification growth. It has been hypothesized that elevated mechanical stress plays a major role in both phases of disease progression. Read More

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http://dx.doi.org/10.1098/rsif.2019.0893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328384PMC

Comparison of transcatheter patent ductus arteriosus closure between children and adults.

Heart Vessels 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatric Cardiology, Saitama Medical University International Medical Center, 1397-1, Yamane, Hidaka City, Saitama, 350-1298, Japan.

The data comparing the characteristics and effect of transcatheter patent ductus arteriosus (PDA) closure between children and adults is scarce. We analyzed 54 consecutive patients who underwent transcatheter PDA closures. We divided the patients into 2 groups of < 18 years and ≥ 18 years and compared the hemodynamic changes before and after the PDA closure. Read More

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http://dx.doi.org/10.1007/s00380-020-01639-4DOI Listing

Skeletal abnormalities secondary to antenatal etidronate treatment for suspected generalised arterial calcification of infancy.

Bone Rep 2020 Jun 13;12:100280. Epub 2020 May 13.

Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Background: Generalised arterial calcification of infancy (GACI) is a rare disorder characterised by the deposition of hydroxyapatite crystals within the vessel walls. It is associated with a high mortality rate. Bisphosphonates have been used with some success in the treatment of GACI. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256299PMC

Combined Coronary CT-Angiography and TAVI-Planning: A Contrast-Neutral Routine Approach for Ruling-out Significant Coronary Artery Disease.

J Clin Med 2020 May 27;9(6). Epub 2020 May 27.

Department of Diagnostic and Interventional Radiology, Heart Center Leipzig, Strümpellstr. 39, 04289 Leipzig, Germany.

Background: Significant coronary artery disease (CAD) is a common finding in patients undergoing transcatheter aortic valve implantation (TAVI). Assessment of CAD prior to TAVI is recommended by current guidelines and is mainly performed via invasive coronary angiography (ICA). In this study we analyzed the ability of coronary CT-angiography (cCTA) to rule out significant CAD (stenosis ≥ 50%) during routine pre-TAVI evaluation in patients with high pre-test probability for CAD. Read More

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http://dx.doi.org/10.3390/jcm9061623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356559PMC

Microparticles (Exosomes) and Atherosclerosis.

Curr Atheroscler Rep 2020 May 28;22(6):23. Epub 2020 May 28.

Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China.

Purpose Of Review: This review summarizes the effects of microparticles and exosomes in the progression of atherosclerosis and the prospect for their diagnostic and therapeutic potentials.

Recent Findings: Microparticles and exosomes can induce endothelial dysfunction, vascular inflammation, coagulation, thrombosis, and calcification via their components of proteins and noncoding RNAs, which may promote the progression of atherosclerosis. The applications of microparticles and exosomes become the spotlight of clinical diagnosis and therapy. Read More

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http://dx.doi.org/10.1007/s11883-020-00841-zDOI Listing

One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility.

J Control Release 2020 May 25;324:471-481. Epub 2020 May 25.

Utah Center for Nanomedicine, Nano Institute of Utah, and University of Utah, Salt Lake City, Utah, United States; Department of Pharmaceutics and Pharmaceutical Chemistry, Nano Institute of Utah, and University of Utah, Salt Lake City, Utah, United States; Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United States. Electronic address:

Chronic toxicity evaluations of nanotechnology-based drugs are essential to support initiation of clinical trials. Ideally such evaluations should address the dosing strategy in human applications and provide sufficient information for long-term usage. Herein, we investigated one-year toxicity of non-surface modified silica nanoparticles (SNPs) with variations in size and porosity (Stöber SNPs 46 ± 4. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.05.027DOI Listing

Morphomic calcification score from clinical CT scans: A proxy for coronary artery calcium.

Clin Imaging 2020 Apr 18;66:57-63. Epub 2020 Apr 18.

Morphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA; Department of Surgery, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Background: Screening of cardiovascular risk is essential in preventing cardiac events and quantifying asymptomatic risk. Coronary artery calcium (CAC) scores are a well-established in predicting cardiovascular risk, but require specialized computed tomography (CT) scans. Given the relationship of aortic calcification with cardiovascular risk, we sought to determine whether aortic calcification measures from incidental CT scans may approximate CAC. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.03.017DOI Listing
April 2020
0.596 Impact Factor

Cannulation of the carotid artery for minimally invasive mitral or tricuspid valve surgery.

Ann Thorac Surg 2020 May 19. Epub 2020 May 19.

From the Department of Cardiac Surgery, Medical University of Innsbruck.

Remote access perfusion for minimally invasive mitral surgery is commonly achieved by femoro-femoral bypass. We describe the use of the carotid artery as an inflow in two patients with severe calcifications of the abdominal aorta and the iliac arteries who underwent minimally invasive mitral and tricuspid valve repair. The easy and fast access to the vessel and the lack of interference with the transthoracic clamp and the scope are the major advantages of the carotid compared other alternatives such as the axillary artery. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.022DOI Listing

Left Atrial High-grade Sarcoma With Focal Osteosarcomatous Differentiation.

Cureus 2020 Apr 13;12(4):e7660. Epub 2020 Apr 13.

Cardiology, Palmetto General Hospital, Hialeah, USA.

Approximately 75% of cardiac tumors are benign, and 25% are malignant cardiac tumors. Of these, sarcomas are extremely rare and have been described in isolated case reports. Due to its rarity, there is no published guideline for the management of this pathological entity. Read More

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http://dx.doi.org/10.7759/cureus.7660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219016PMC

Transcatheter Closure of Patent Ductus Arteriosus in Elderly Patients: Initial and One-Year Follow-Up Results-Do We Have the Proper Device?

J Interv Cardiol 2020 29;2020:4585124. Epub 2020 Apr 29.

Department of Congenital Heart Defects and Paediatric Cardiology, FMS in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland.

Objectives: Patent ductus arteriosus (PDA) in elderly patients is an uncommon anomaly, and the duct itself is often calcified and fragile; therefore, transcatheter closure is more difficult. The aim is to analyse periprocedural and one-year follow-up results of transcatheter closure of PDA in such patients. . Read More

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http://dx.doi.org/10.1155/2020/4585124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206884PMC

Intra-atrial neo-mitral ring creation in the presence of severe mitral annulus calcification.

Ann Thorac Surg 2020 May 7. Epub 2020 May 7.

Department of Cardiothoracic Surgery, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany.

Severe mitral annulus calcifications significantly hinder surgical repair and replacement of the dysfunctional mitral valve. Herein, we present a novel surgical technique where we created an intra-atrial neo-mitral ring using a vascular Dacron graft in which a prosthetic valve was implanted. This approach is a simple alternative technique that can be used when anatomic prosthetic valve implantation is not feasible. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.100DOI Listing

Use of Tourniquet During Knee Arthroplasty in Patients With Radiographic Arterial Calcifications.

J Arthroplasty 2020 Aug 11;35(8):2050-2053. Epub 2020 Apr 11.

Department of Orthopaedics, Heart and General Hospital, Jaipur, Rajasthan, India.

Background: Use of tourniquet during total knee arthroplasty (TKA) in patients with radiographic arterial calcifications is controversial. Intimal arterial calcifications are feared to be associated with ischemic complications such as delayed wound healing and arterial thrombosis, whereas medial calcifications stiffen the arterial wall, possibly leading to tourniquet failure and increased blood loss.

Methods: We conducted a prospective cohort study to determine the incidence of tourniquet failure (inflated up to 300 mm Hg), blood transfusions, wound healing, and ischemic complications in thighs with and without arterial calcifications on preoperative radiographs, in 2548 consecutive primary TKAs conducted in our unit over a 5-year period. Read More

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http://dx.doi.org/10.1016/j.arth.2020.04.011DOI Listing

The association of innate and adaptive immunity, subclinical atherosclerosis, and cardiovascular disease in the Rotterdam Study: A prospective cohort study.

PLoS Med 2020 05 7;17(5):e1003115. Epub 2020 May 7.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

Background: Atherosclerotic cardiovascular disease (ASCVD) is driven by multifaceted contributions of the immune system. However, the dysregulation of immune cells that leads to ASCVD is poorly understood. We determined the association of components of innate and adaptive immunity longitudinally with ASCVD, and assessed whether arterial calcifications play a role in this association. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205222PMC

Validity of epicardial fat volume as biomarker of coronary artery disease in symptomatic individuals: Results from the ALTER-BIO registry.

Int J Cardiol 2020 Sep 13;314:20-24. Epub 2020 Apr 13.

Division of Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. Electronic address:

Background: To determine if an increased epicardial fat volume (EFV) is associated with coronary artery disease (CAD) in individuals with symptoms of cardiovascular (CV) disease.

Methods: Coronary Computed Tomographic Angiography (CCTA), demographic and clinical variables of 1344 individuals were retrieved: semi-automated measurements for EFV and coronary artery calcifications (CAC) were obtained. Individuals were grouped into three categories according to the presence of CAD, resulting in absent (CAD), non-obstructive (CAD) or obstructive (CAD) disease-groups. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.031DOI Listing
September 2020
4.036 Impact Factor

Healed Plaques in Patients With Stable Angina Pectoris.

Arterioscler Thromb Vasc Biol 2020 06 16;40(6):1587-1597. Epub 2020 Apr 16.

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Objective: Healed plaques, signs of previous plaque destabilization, are frequently found in the coronary arteries. Healed plaques can now be diagnosed in living patients. We investigated the prevalence, angiographic, and optical coherence tomography features of healed plaques in patients with stable angina pectoris. Read More

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http://dx.doi.org/10.1161/ATVBAHA.120.314298DOI Listing

Myocardial Calcifications: Thinking Beyond the Heart.

Am J Med 2020 Apr 5. Epub 2020 Apr 5.

Department of Diagnostic & Interventional Imaging, University of Texas Health Science Center at Houston. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.02.045DOI Listing

Hypocalcaemic cardiomyopathy: a description of two cases and a literature review.

ESC Heart Fail 2020 Jun 3;7(3):1291-1301. Epub 2020 Apr 3.

Second Department of Medicine, Department of Cardiovascular Medicine, General University Hospital in Prague and First Faculty of Medicine, Charles University, Prague, Czech Republic.

Hypocalcaemic cardiomyopathy is a rare form of dilated cardiomyopathy. The authors here present two cases in which symptomatic dilated cardiomyopathy was the result of severe hypocalcaemia. First, we report about a 26-year-old woman with primary hypoparathyroidism and then about a 74-year-old man with secondary hypoparathyroidism following a thyroidectomy. Read More

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http://dx.doi.org/10.1002/ehf2.12693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261529PMC

Transfemoral transcatheter aortic valve replacement without contrast medium using the Medtronic CoreValve system: a single center experience.

J Cardiovasc Surg (Torino) 2020 Aug 1;61(4):489-495. Epub 2020 Apr 1.

Department of Cardiothoracic Surgery, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.

Background: Transcatheter aortic valve replacement (TAVR) in patients with chronic kidney disease (CKD) is challenging due to the high risk of contrast-induced nephropathy (CIN) and acute kidney injury (AKI). AKI dramatically reduces the clinical benefit of TAVR and is one of the strongest predictors of 30-day mortality as well as long-term adverse outcomes after TAVR. The aim of this study was to evaluate a protocol specifically designed to reduce the incidence of contrast-induced nephropathy (CIN) in advanced CKD patients screened for and undergoing TAVR. Read More

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http://dx.doi.org/10.23736/S0021-9509.20.11083-8DOI Listing

Cardiovascular Benefits of Extended-Time Nocturnal Hemodialysis.

Curr Vasc Pharmacol 2020 Apr 1. Epub 2020 Apr 1.

Humber River Regional Hospital, University of Toronto, Ontario. Canada.

Hemodialysis (HD) remains the most utilized treatment for End Stage Kidney Disease (ESKD) globally, mainly as conventional HD administered in 4 h sessions thrice weekly. Despite advances in HD delivery, patients with ESKD carry a heavy cardiovascular morbidity and mortality burden. This is associated with cardiac remodeling, left ventricular hypertrophy (LVH), myocardial stunning, hypertension, decreased heart rate variability, sleep apnea, coronary calcification and endothelial dysfunction. Read More

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http://dx.doi.org/10.2174/1570161118666200401112106DOI Listing

Post-mortem histology in transient receptor potential cation channel subfamily V member 6 (TRPV6) under-mineralising skeletal dysplasia suggests postnatal skeletal recovery: a case report.

BMC Med Genet 2020 03 30;21(1):64. Epub 2020 Mar 30.

Severn Pathology, Paediatric and Perinatal Pathology, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.

Background: The calcium-selective channel TRPV6 (transient receptor potential cation channel subfamily V member 6) is crucial for maternal-fetal calcium transport across the placenta. TRPV6 mutations have recently been associated with an antenatally severe under-mineralising skeletal dysplasia accompanied by postnatal biochemical abnormalities. This is the first post-mortem report in a patient with TRPV6 skeletal dysplasia. Read More

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http://dx.doi.org/10.1186/s12881-020-01007-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106792PMC

A Finite Element Analysis Study from 3D CT to Predict Transcatheter Heart Valve Thrombosis.

Diagnostics (Basel) 2020 Mar 26;10(4). Epub 2020 Mar 26.

Department of Civil Engineering and Architecture, University of Pavia, 27100 Pavia, Italy.

Background: Transcatheter aortic valve replacement has proved its safety and effectiveness in intermediate- to high-risk and inoperable patients with severe aortic stenosis. However, despite current guideline recommendations, the use of transcatheter aortic valve replacement (TAVR) to treat severe aortic valve stenosis caused by degenerative leaflet thickening and calcification has not been widely adopted in low-risk patients. This reluctance among both cardiac surgeons and cardiologists could be due to concerns regarding clinical and subclinical valve thrombosis. Read More

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http://dx.doi.org/10.3390/diagnostics10040183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235717PMC

The role of parathyroidectomy in treating hypertension and other cardiac manifestations of primary hyperparathyroidism.

Gland Surg 2020 Feb;9(1):136-141

Diabetes and Endocrinology Institute, Banner - University Medical Center Phoenix, Phoenix, AZ, USA.

Among many recognized sequelae of primary hyperparathyroidism (PHPT), cardiovascular disease remains incompletely understood as a consequence of disordered calcium and parathyroid hormone (PTH) metabolism. While population studies have identified trends that associate PHPT with hypertension, metabolic syndrome, and vascular system calcifications, the fundamental pathophysiology, natural history, and opportunity to reverse or cure the cardiovascular effects with parathyroidectomy are not well established. This chapter reviews the current knowledge of this field of interest within PHPT and summarizes key findings from dedicated investigations that have addressed the impact of parathyroid surgery on the cardiovascular system. Read More

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http://dx.doi.org/10.21037/gs.2019.12.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082270PMC
February 2020

Visually assessed coronary and cardiac calcium outperforms perfusion data during scintigraphy in the prediction of adverse outcomes.

Int J Cardiol 2020 Aug 12;312:123-128. Epub 2020 Mar 12.

Istituto Sant'anna, Pisa, Italy.

Objectives: To determine whether calcifications of the coronary arteries (coronary artery calcium 0 to 4 score), or extending the assessment also to cardiac valves and thoracic aorta (overall calcium 0 to 8 score), as seen on computed tomography for attenuation correction during stress-scintigraphy (SPECT-CT), are associated with total mortality and non-fatal myocardial infarction. We aimed to assess whether these calcifications added to the prognostic value of SPECT imaging.

Background: The presence/amount of calcium in the coronary arteries, but also in the heart valves and aorta, has been associated with cardiovascular (CV) and all-cause mortality. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.03.032DOI Listing

Ultrasound-Navigated MANTA™ deployment after Removal of Extracorporeal Membrane Oxygenation Cannula.

Ann Thorac Surg 2020 Mar 4. Epub 2020 Mar 4.

Heart and Lung Center, Helsinki University Hospital, Finland.

The case provided suggests that ultrasound-navigated MANTA™ works well closing percutaneously the peripheral arterial ECMO cannulation site. Ultrasound use during ECMO decannulation can further diminish the possible device related technical failures (toggle or collagen protrusion through the vessel wall, toggle stacking into calcifications, or delivery failure of the collagen pad) leading to bleeding and vascular complications. Further studies are needed on this topic. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.01.064DOI Listing

Massive Bilateral Hydroureteronephrosis and End-Stage Renal Disease Ensuing From Chronic Schistosomiasis: A Case Report.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620910912

Jakaya Kikwete Cardiac Institute, Dar es Salaam, Tanzania.

Globally, schistosomal infections affect over 200 million people resulting in the loss of 70 million disability-adjusted life years. In the sub-Saharan Africa region, where over 85% of the global schistosomal infections are found, it is estimated that about 120 million people become symptomatic, over 20 million have severe disease, and nearly 200 000 die every year. Renal impairment is a severe consequence of schistosomiasis occurring in about 6% of all infected individuals and in 15% of those with the hepatosplenic form. Read More

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http://dx.doi.org/10.1177/2324709620910912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059228PMC

Complete and sustained resolution of calcinosis universalis in a juvenile dermatomyositis case with mycophenolate mofetil.

Turk J Pediatr 2019 ;61(5):771-775

Clinic of Pediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, İstanbul, Turkey.

Çakan M, Karadağ ŞG, Aktay Ayaz N. Complete and sustained resolution of calcinosis universalis in a juvenile dermatomyositis case with mycophenolate mofetil. Turk J Pediatr 2019; 61: 771-775. Read More

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http://dx.doi.org/10.24953/turkjped.2019.05.018DOI Listing
January 2019

A case of bi-ventricular extensive calcification caused by multiple factors.

BMC Pediatr 2020 02 22;20(1):85. Epub 2020 Feb 22.

Dept of Pediatrics, Renmin Hospital of Wuhan University , Wuhan, 430060, Hubei Province, People's Republic of China.

Background: Extensive myocardial calcification has a low incidence rate, but when the patients do have extensive myocardial cases, the prognosis is usually poor. Several sepsis-related extensive myocardial calcification cases have been reported, but there are cases of biventricular calcifications that are caused by multiple cases besides bacteremia and the treatment for it has a low percentage of success.

Case Presentation: A 9 year old girl had an extensive biventricular calcification which is caused by multiple factors including multiple organ failure (heart, lung, liver, and kidney), aseptic cardiomyopathy, systemic inflammatory response syndrome, pulmonary hemorrhage, viral encephalitis. Read More

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http://dx.doi.org/10.1186/s12887-020-1973-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036240PMC
February 2020

Utility of routine non-gated CT chest in detection of subclinical atherosclerotic calcifications of coronary arteries in hospitalised HIV patients.

Br J Radiol 2020 May 28;93(1109):20190462. Epub 2020 Feb 28.

Department of Medicine/Cardiology, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, United States.

Objectives: To evaluate coronary artery calcification (CAC) on routine CT chest in hospitalised HIV patients and to assess individual risk factors.

Methods: Routine CT chests, May 2010-November 2015, of 143 hospitalised HIV-positive patients were reviewed for qualitative assessment of calcification in major coronary arteries by two radiologists. Presence, location and burden of calcification were evaluated on 3 mm axial images of CT chest. Read More

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http://dx.doi.org/10.1259/bjr.20190462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217561PMC

Coronary atherosclerosis in middle-aged athletes: Current insights, burning questions, and future perspectives.

Clin Cardiol 2020 Aug 7;43(8):863-871. Epub 2020 Feb 7.

Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Regular exercise training is considered healthy as it reduces the risk of cardiovascular events and mortality. Nevertheless, athletes are not immune to the development of cardiovascular diseases and recent studies reported a higher prevalence of coronary artery calcifications and atherosclerotic plaques in athletes compared to less active controls. These observations have raised many questions among sport scientists, sports cardiologists, amateur athletes, and the general population. Read More

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http://dx.doi.org/10.1002/clc.23340DOI Listing

Pathology of radiation induced heart disease.

Authors:
Ivo Šteiner

Rep Pract Oncol Radiother 2020 Mar-Apr;25(2):178-181. Epub 2019 Dec 17.

The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.

The aim of this paper is dual - to review the relevant literature on pathology of radiation induced heart disease (RIHD), and to present an illustrative case of our own. Therapeutic ionizing radiation, such as that used in the treatment of Hodgkin´s lymphoma and cancers of left breast, lungs, esophagus, and thymus, can cause cardiac damage that may take several years to manifest. The spectrum of RIHD is broad and includes [1] pericarditis and pericardial effusion; [2] endocardial fibrosis and valvular dysfunction; [3] nonischemic myocardial fibrosis; [4] obstructive coronary artery disease with resultant myocardial ischemia; [5] damage to the great vessels; and [6] conduction system dysfunction. Read More

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http://dx.doi.org/10.1016/j.rpor.2019.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994278PMC
December 2019

A biomechanical model of the pathological aortic valve: simulation of aortic stenosis.

Comput Methods Biomech Biomed Engin 2020 Jun 29;23(8):303-311. Epub 2020 Jan 29.

Cardiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), Alvaro Cunqueiro Hospital, SERGAS, Vigo, Spain.

Aortic stenosis (AS) disease is a narrowing of the aortic valve (AV) opening which reduces blood flow from the heart causing several health complications. Although a lot of work has been done in AV simulations, most of the efforts have been conducted regarding healthy valves. In this article, a new three-dimensional patient-specific biomechanical model of the valve, based on a parametric formulation of the stenosis that permits the simulation of different degrees of pathology, is presented. Read More

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http://dx.doi.org/10.1080/10255842.2020.1720001DOI Listing

Apolipoproteins A and B and PCSK9: Nontraditional Cardiovascular Risk Factors in Chronic Kidney Disease and in End-Stage Renal Disease.

J Diabetes Res 2019 14;2019:6906278. Epub 2019 Dec 14.

Department of Nephrology, "Dr. C. I. Parhon" Clinical Hospital Iasi, Iasi, Romania.

Purpose: Nontraditional cardiovascular risk factors as apolipoprotein A (ApoA), apolipoprotein B (ApoB), and the proprotein convertase subtilisin/kexin type 9 (PCSK9) increase the prevalence of cardiovascular mortality in chronic kidney disease (CKD) or in end-stage renal disease (ESRD) through quantitative alterations. This review is aimed at establishing the biomarker (ApoA, ApoB, and PCSK9) level variations in uremic patients, to identify the studies showing the association between these biomarkers and the development of cardiovascular events and to depict the therapeutic options to reduce cardiovascular risk in CKD and ESRD patients.

Methods: We searched the electronic database of PubMed, Scopus, EBSCO, and Cochrane CENTRAL for studies evaluating apolipoproteins and PCSK9 in CKD and ESRD. Read More

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http://dx.doi.org/10.1155/2019/6906278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931031PMC

Frequency and Incidence of Carney Complex Manifestations: A Prospective Multicenter Study With a Three-Year Follow-Up.

J Clin Endocrinol Metab 2020 Mar;105(3)

INSERM U1016, CNRS UMR8104, Institut Cochin, Université Paris Descartes, Paris.

Introduction: Carney Complex (CNC) is a rare multiple endocrine and nonendocrine neoplasia syndrome. Manifestations and genotype-phenotype correlations have been described by retrospective studies, but no prospective study evaluating the occurrence of the different manifestations has been available so far.

Methods: This multicenter national prospective study included patients with CNC, primary pigmented nodular adrenal disease (PPNAD), or a pathogenic PRKAR1A mutation; after a full initial workup, participants were followed for 3 years with annual standardized evaluation. Read More

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http://dx.doi.org/10.1210/clinem/dgaa002DOI Listing

Coronary calcification segmentation in intravascular OCT images using deep learning: application to calcification scoring.

J Med Imaging (Bellingham) 2019 Oct 27;6(4):045002. Epub 2019 Dec 27.

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.

Major calcifications are of great concern when performing percutaneous coronary interventions because they inhibit proper stent deployment. We created a comprehensive software to segment calcifications in intravascular optical coherence tomography (IVOCT) images and to calculate their impact using the stent-deployment calcification score, as reported by Fujino et al. We segmented the vascular lumen and calcifications using the pretrained SegNet, convolutional neural network, which was refined for our task. Read More

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http://dx.doi.org/10.1117/1.JMI.6.4.045002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934132PMC
October 2019

Intracranial calcifications under vitamin K antagonists or direct oral anticoagulants: Results from the French VIKING study in older adults.

Maturitas 2020 Feb 3;132:35-39. Epub 2019 Dec 3.

Department of Geriatric Medicine, Angers University Hospital, Angers, France; Angers University Memory Clinic, Angers, France; Research Center on Autonomy and Longevity, Angers, France; UPRES EA 4638, University of Angers, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada. Electronic address:

Objectives: The use of vitamin K antagonists (VKA) is associated with the onset of vascular and soft-tissue calcifications. Whether there are more intracranial calcifications under VKA remains unclear. The objective of this study was to determine whether the regular use of VKA in older adults was associated with an increased burden of intracranial calcifications compared with the use of direct oral anticoagulant (DOA). Read More

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http://dx.doi.org/10.1016/j.maturitas.2019.12.003DOI Listing
February 2020