2,507 results match your criteria Carcinoma of the Ampulla of Vater


The Prognostic Relevance of the New 8th Edition of the Union for International Cancer Control Classification of TNM Staging for Ampulla of Vater Carcinoma.

Ann Surg Oncol 2019 Feb 21. Epub 2019 Feb 21.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Centre, Sunto-Nagaizumi, Shizuoka, Japan.

Objective: The aim of this study was to investigate the clinical relevance of the 8th edition of the Union for International Cancer Control classification of TNM staging for ampulla of Vater carcinoma (AC).

Methods: A total of 104 consecutive patients who underwent macroscopic curative resection for AC between January 2002 and September 2017 were investigated.

Results: Significant differences in recurrence-free survival (RFS) were found between T1a and T1b (p = 0. Read More

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http://dx.doi.org/10.1245/s10434-019-07238-6DOI Listing
February 2019

Long-term Survival of Patient with Ampulla of Vater Metastasis of Renal Cell Carcinoma.

Prague Med Rep 2018 ;119(4):165-169

Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Ampulla of Vater metastases from renal cell carcinoma are rare. The time between detection of the primary tumour and its metastasis may extend to years. Management should be aggressive, since the prognosis of renal cell carcinoma is unpredictable and curative surgery of metastases may extend patient survival and even lead to definite cure. Read More

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http://dx.doi.org/10.14712/23362936.2019.4DOI Listing
January 2018

Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers: A Nationwide Population-Based Study.

Pancreas 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Objectives: We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea.

Methods: We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001254DOI Listing
February 2019
1 Read

[Combined application of immunohistochemical markers to identify pathologic subtypes of ampullary carcinoma and its clinical significance].

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):92-97

Department of Pathology, Peking University People's Hospital, Beijing 100044, China.

To investigate the expression of immunomarkers CK7, CK20, CK17, CDX2, MUC1 and MUC2 in primary adenocarcinoma of the ampulla of Vater, to explore the role of these markers in the histopathologic subclassification of ampullary carcinoma; and to provide biologic basis for precision treatment of patients with different types of ampullary carcinoma. Forty-two cases of primary ampullary carcinoma were collected at Peking University People's Hospital, from 2012 to 2018 year. There were 22 males and 20 females. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.003DOI Listing
February 2019
1 Read

Pancreatic Mass in a Patient with a History of Resected Renal Cell Carcinoma and Resected Adenocarcinoma of the Ampulla of Vater: A Case Report.

J Pancreat Cancer 2018 1;4(1):41-44. Epub 2018 Aug 1.

Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Metastases of renal cell carcinoma (RCC) to the pancreas are rare, whereas recurrence of pancreatic ductal adenocarcinoma (PDA) or a primary periampullary cancer is far more common. The time elapsed between a primary tumor and a new mass can aid in differentiation between the two. A 70-year-old man with a history of RCC status after left nephrectomy and ampullary adenocarcinoma status after pancreaticoduodenectomy presents with an incidentally found mass in his remnant pancreas. Read More

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http://www.liebertpub.com/doi/10.1089/pancan.2018.0001
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http://dx.doi.org/10.1089/pancan.2018.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145538PMC
August 2018
3 Reads

Robotic transduodenal ampullectomy: A novel minimally invasive approach for ampullary neoplasms.

Int J Med Robot 2018 Dec 22:e1979. Epub 2018 Dec 22.

Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.

Background: The adoption of minimally invasive surgery for transduodenal ampullectomy has been slow because of special characteristics and complexity of this procedure.

Methods: Six patients underwent robotic transduodenal ampullectomy. We employed novel methods to facilitate exposure of the ampulla. Read More

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http://doi.wiley.com/10.1002/rcs.1979
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http://dx.doi.org/10.1002/rcs.1979DOI Listing
December 2018
7 Reads

Incidence and comparative outcomes of periampullary cancer: A population-based analysis demonstrating improved outcomes and increased use of adjuvant therapy from 2004 to 2012.

J Surg Oncol 2019 03 18;119(3):303-317. Epub 2018 Dec 18.

Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background And Objectives: Periampullary adenocarcinoma (PAC) is stratified anatomically: ampullary adenocarcinoma (AA), distal cholangiocarcinoma (DCC), duodenal adenocarcinoma (DA), and pancreatic ductal adenocarcinoma (PDAC). We aimed to determine differences in incidence, prognosis, and treatment in stage-matched PAC patients in a longitudinal study.

Methods: PAC patients were identified in The National Cancer Database from 2004 to 2012. Read More

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http://dx.doi.org/10.1002/jso.25336DOI Listing
March 2019
2 Reads

Identification of ampullary carcinoma mixed subtype using a panel of six antibodies and its clinical significance.

J Surg Oncol 2019 Mar 12;119(3):295-302. Epub 2018 Dec 12.

Pathology and Laboratory Medicine Department, University of California, Los Angeles, California.

Objectives: To investigate the function of immunomarkers CK7, CK20, CK17, CDX2, MUC1, and MUC2 in the identification of primary ampullary carcinoma mixed subtype.

Methods: Forty-two cases of primary ampullary carcinoma were performed by immunohistochemical studies. The correlation between the mixed subtype and the other two subtypes and patient survival data was analyzed using the SPSS 16. Read More

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http://dx.doi.org/10.1002/jso.25311DOI Listing

Brain metastasis and herniation in a patient with ampullary adenocarcinoma presenting with jaundice and memory loss: case report.

J Gastrointest Oncol 2018 Oct;9(5):871-874

Multiple Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Periampullary carcinoma includes neoplasms arising from head of pancreas, distal common bile duct, duodenum and ampulla of Vater. We report a case of a 41-year-old male, medically free who presented to our hospital as a case of obstructive jaundice, weight loss, headache and blurred vision. Clinical evaluation revealed memory loss and ataxia. Read More

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http://dx.doi.org/10.21037/jgo.2018.05.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219980PMC
October 2018
7 Reads

Ampulla of Vater carcinoma: Molecular landscape and clinical implications.

World J Gastrointest Oncol 2018 Nov;10(11):370-380

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona 37134, Italy.

Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. Read More

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http://dx.doi.org/10.4251/wjgo.v10.i11.370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247104PMC
November 2018
1 Read

Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis.

Pancreas 2019 Jan;48(1):70-76

Department of General and Pancreatic Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.

Objective: Ampulla of Vater carcinoma (AVC) has a broad spectrum of different prognoses. As such, new moderators of survival are urgently needed. We aimed at clarifying the prognostic role of perineural invasion in AVC. Read More

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http://Insights.ovid.com/crossref?an=00006676-900000000-9850
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http://dx.doi.org/10.1097/MPA.0000000000001194DOI Listing
January 2019
16 Reads
2.959 Impact Factor

Statin use and reduced risk of biliary tract cancers in the UK Clinical Practice Research Datalink.

Gut 2018 Nov 17. Epub 2018 Nov 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Objective: To evaluate the association between statin use and risk of biliary tract cancers (BTC).

Design: This is a nested case-control study conducted in the UK Clinical Practice Research Datalink. We included cases diagnosed with incident primary BTCs, including cancers of the gall bladder, bile duct (ie, both intrahepatic and extrahepatic cholangiocarcinoma), ampulla of Vater and mixed type, between 1990 and 2017. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317504DOI Listing
November 2018
2 Reads

High-grade precursor lesions can be used as surrogate markers to identify the epicenter of periampullary carcinomas.

Hum Pathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Identifying the accurate origin of periampullary cancers is important, because different origins may trigger different clinicopathologic behaviors. The presence of intraepithelial precursor lesions, including high-grade pancreatic intraepithelial neoplasias (PanINs) and/or high-grade biliary intraepithelial neoplasias (BilINs), may be suggestive of the origin of the periampullary carcinoma in challenging cases. To prove the usefulness of high-grade intraepithelial precursor lesions to identify the origin of ambiguous periampullary cancers, the status and grades of PanINs and BilINs were evaluated in 256 periampullary carcinomas with a well-defined cancer origin as a test set, including 114 pancreatic cancers, 82 distal bile duct cancers, 54 ampullary cancers, and 6 duodenal cancers, and 112 periampullary carcinomas with clinically equivocal epicenter either by radiologic imaging used as a validation set. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183036
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http://dx.doi.org/10.1016/j.humpath.2018.09.006DOI Listing
September 2018
17 Reads
2.770 Impact Factor

'Bleeding Dilemma': The Story of a Periampullary Mass.

Cureus 2018 Jul 23;10(7):e3035. Epub 2018 Jul 23.

UAB Medicine, Huntsville Regional Medical Campus, Huntsville Hospital, Huntsville, USA.

Periampullary malignancies arise in the vicinity of the ampulla of Vater, a common passage for biliary and pancreatic secretions. Determining the anatomical origin of these tumors represents a diagnostic challenge. This is especially true for large tumors due to the transitional nature of this region, proximity to different structures, anatomical variations, and overlapping features among constituting structures. Read More

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http://dx.doi.org/10.7759/cureus.3035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150752PMC
July 2018
20 Reads

Clinicopathological Stratification and Long-term Follow-up of Patients with Periampullary Carcinomas.

Anticancer Res 2018 Sep;38(9):5379-5386

Department of Surgery, Charité University of Medicine Berlin, Berlin, Germany.

Background: Periampullary carcinomas generally confer a poor outcome. Choosing the most effective treatment regimen for each sub-entity proves challenging and is usually based on experience from pancreatic adenocarcinoma (PDAC).

Patients And Methods: The long-term follow-up is presented of 472 patients with periampullary tumors [PDAC, distal cholangiocarcinoma (dCC) and ampullary carcinomas (AC)] who underwent radical resection considering clinical characteristics, paraclinical findings and histopathological features in order to define factors of prognostic relevance. Read More

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http://dx.doi.org/10.21873/anticanres.12867DOI Listing
September 2018
6 Reads

[Solitary Pulmonary Metastasis from Carcinoma of the Ampulla of Vater after Pancreatoduodenectomy;Report of a Case].

Kyobu Geka 2018 09;71(9):708-711

Department of General Thoracic Surgery, Japanese Red Cross Kobe Hospital/Kobe University, Kobe, Japan.

A 74-year-old woman had underwent pancreatoduodenectomy for a carcinoma of the ampulla of Vater. After 3 years of the operation, chest computed tomography (CT) scan showed a solitary nodule in the right posterior segment (S2). Under the diagnosis of solitary pulmonary metastasis, we performed wedge resection for the right S2 lesion under video-assisted thoracic surgery (VATS). Read More

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September 2018
2 Reads

Periampullary Neuroendocrine Tumor as a Cause of Acute Pancreatitis.

Am J Case Rep 2018 Sep 5;19:1063-1067. Epub 2018 Sep 5.

Department of Surgery, Mount Lebanon Hospital, Beirut, Lebanon.

BACKGROUND Duodenal and ampullary carcinoids are very rare tumors accounting respectively for 2% and 0.03% of all carcinoid tumors. Clinical findings vary according to the location of the tumor within the periampullary region; with epigastric pain being the most common presenting symptom in duodenal carcinoids and jaundice the most common clinical finding in ampullary carcinoids. Read More

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https://www.amjcaserep.com/abstract/index/idArt/908205
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http://dx.doi.org/10.12659/AJCR.908205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135042PMC
September 2018
14 Reads

Bronchobiliary fistula: a rare complication after pancreaticoduodenectomy.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Biliary anatomic pathologies are rare disease occurrences that can result from a number of causes, most commonly iatrogenic, infectious and malignant aetiologies. Communications between the biliary and bronchial systems are even rarer and few cases have been documented in the literature. The present study describes a case of a 70-year-old man who underwent a pancreaticoduodenectomy (Whipple Procedure) as a curative procedure for an early stage neuroendocrine tumour. Read More

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http://dx.doi.org/10.1136/bcr-2017-221895DOI Listing
September 2018
26 Reads

Associations between autoimmune conditions and hepatobiliary cancer risk among elderly US adults.

Int J Cancer 2019 Feb 8;144(4):707-717. Epub 2018 Nov 8.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992-2013) to conduct a population-based, case-control study. Read More

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http://dx.doi.org/10.1002/ijc.31835DOI Listing
February 2019
9 Reads

Predictors of long-term survival after pancreaticoduodenectomy for peri-ampullary adenocarcinoma: A retrospective study of 5-year survivors.

Hepatobiliary Pancreat Dis Int 2018 Oct 7;17(5):443-449. Epub 2018 Aug 7.

Gastroenterology Surgical Center, Mansoura University, Mansoura 35516, Egypt.

Background: Pancreaticoduodenectomy (PD) is the standard curative treatment for periampullary tumors. The aim of this study is to report the incidence and predictors of long-term survival (≥ 5 years) after PD.

Methods: This study included patients who underwent PD for pathologically proven periampullary adenocarcinomas. Read More

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http://dx.doi.org/10.1016/j.hbpd.2018.08.004DOI Listing
October 2018
5 Reads

[Ampulloma treatment with Whipple surgery. First case report in the regional hospital of Tumbes].

Rev Gastroenterol Peru 2018 Apr-Jun;38(2):187-191

Hospital Regional de Tumbes. Tumbes, Perú.

To report the first case of Whipple surgery performed at the Regional Hospital of Tumbes for the treatment of ampullary adenocarcinoma with successful results. A case report of a patient with diagnosis of ampullary adenocarcinoma, in whom was performed the first Whipple surgery at the Regional Hospital of Tumbes, in October, 2014. The patient diagnosed with an obstructive jaundice syndrome due to ampullary adenocarcinoma underwent Whipple surgery. Read More

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December 2018
4 Reads

Histopathologic differentiation as a prognostic factor in patients with carcinoma of the hepatopancreatic ampulla of Vater.

J Int Med Res 2018 Nov 20;46(11):4634-4639. Epub 2018 Jul 20.

3 Pathology Department, University of Nis Medical School, Bul.dr Z.Djindjica, Nis, Serbia.

Objective: Periampullary carcinomas are a group of neoplasms with variable histopathology that originate from the anatomical junction of different epithelial types including the bile duct, pancreatic duct, and duodenal mucosa. This study was performed to determine whether the histopathologic type of these tumors should be considered an independent prognostic factor.

Methods: We analyzed the specimen histopathology of 37 patients who underwent radical cephalic pancreatoduodenectomy for carcinoma of the ampulla of Vater during a 5-year period. Read More

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http://dx.doi.org/10.1177/0300060518786920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259412PMC
November 2018
4 Reads
1.095 Impact Factor

Primary small bowel adenomas and adenocarcinomas-recent advances.

Virchows Arch 2018 Sep 11;473(3):265-273. Epub 2018 Jul 11.

Pathology Department, & Centre for Colorectal Disease, UCD Medical School, St. Vincent's University Hospital, Dublin, Ireland.

The small intestine represents 75% of the length and 90% of the absorptive surface area of the gastrointestinal tract (GIT), yet only 2% of digestive system cancers occur at this site. Adenocarcinoma accounts for half of small bowel malignancies. There have been a number of important recent advances in our understanding, classification and treatment of small bowel tumours. Read More

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http://dx.doi.org/10.1007/s00428-018-2400-7DOI Listing
September 2018
22 Reads

Adenosquamous Carcinoma of the Ampulla of Vater: A Rare Cause of Obstructive Jaundice.

GE Port J Gastroenterol 2018 Jun 26;25(4):195-197. Epub 2017 Oct 26.

Gastroenterology Department, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

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http://dx.doi.org/10.1159/000481457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029213PMC
June 2018
2 Reads

Signet Ring Cell Carcinoma of the Ampulla of Vater With Focal Neuroendocrine Differentiation of the Amphicrine Type: Report of a Case With Long-Term Survival.

Int J Surg Pathol 2019 Feb 11;27(1):89-93. Epub 2018 Jul 11.

6 Unit of Digestive Endoscopy, Università Cattolica del Sacro Cuore, Rome, Italy.

Carcinoma of the ampulla of Vater is an uncommon neoplasm and represents 0.5% of all gastrointestinal malignancies, being less common than carcinoma of the pancreas and bile ducts. The most common ampullary tumor is the adenocarcinoma with tubular growth pattern. Read More

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http://dx.doi.org/10.1177/1066896918784666DOI Listing
February 2019
24 Reads

Expanding laparoscopic pancreaticoduodenectomy to pancreatic-head and periampullary malignancy: major findings based on systematic review and meta-analysis.

BMC Gastroenterol 2018 Jul 3;18(1):102. Epub 2018 Jul 3.

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.

Background: Laparoscopic pancreaticoduodenectomy (LPD) remains to be established as a safe and effective alternative to open pancreaticoduodenectomy (OPD) for pancreatic-head and periampullary malignancy. The purpose of this meta-analysis was to compare LPD with OPD for these malignancies regarding short-term surgical and long-term survival outcomes.

Methods: A literature search was conducted before March 2018 to identify comparative studies in regard to outcomes of both LPD and OPD for the treatment of pancreatic-head and periampullary malignancies. Read More

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http://dx.doi.org/10.1186/s12876-018-0830-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029373PMC
July 2018
9 Reads

Transduodenal ampullectomy for ampullary tumors - single center experience of consecutive 26 patients.

Ann Surg Treat Res 2018 Jul 26;95(1):22-28. Epub 2018 Jun 26.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Transduodenal ampullectomy (TDA) has been reported in a limited number of cases and in a small number of case series. The aim of this study was to analyze perioperative and long-term oncological outcomes of patients with ampullary tumors who underwent TDA in a single large-volume center.

Methods: Through a retrospective review of data from 2004 to 2016, we identified 26 patients who underwent TDA at Asan Medical Center. Read More

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http://dx.doi.org/10.4174/astr.2018.95.1.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024084PMC
July 2018
15 Reads

Long-term complete remission of a patient with high grade neuroendocrine carcinoma of ampulla of Vater.

BMJ Case Rep 2018 Jun 27;2018. Epub 2018 Jun 27.

Radiation-Oncology Department, Shohada-e Tajrish Hospital, Tehran, Iran.

We describe a case report of a 53-year-old man with a 5-months history of progressive jaundice and upper abdominal pain. The patient was further evaluated and finally diagnosed with a high-grade ampullary neuroendocrine tumour (based on endoscopic-guided biopsy). Thereafter, he underwent pancreatoduodenectomy and adjuvant platinum-based chemotherapy. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22484
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http://dx.doi.org/10.1136/bcr-2018-224845DOI Listing
June 2018
7 Reads

Prognostic factors of non-ampullary duodenal adenocarcinoma.

Jpn J Clin Oncol 2018 Aug;48(8):743-747

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Yufu, Oita, Japan.

Background: Non-ampullary duodenal adenocarcinoma, excluding carcinoma in the ampulla of Vater, is a rare disease. Although several prognostic factors have been reported, they remain controversial due to the rarity of non-ampullary duodenal adenocarcinoma. The aims of this study were to investigate prognostic factors in patients with non-ampullary duodenal adenocarcinoma and to assess chemotherapy in patients with recurrence. Read More

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http://dx.doi.org/10.1093/jjco/hyy086DOI Listing
August 2018
3 Reads

Ampullary carcinoma-A genetic perspective.

Mutat Res 2018 Apr - Jun;776:10-22. Epub 2018 Mar 17.

Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women - Avinashilingam University for Women, Coimbatore 641 043, Tamil Nadu, India.

Ampulla of vater carcinoma (AVC) is a rare gastrointestinal tumour that is associated with a high mortality rate and it's often diagnosed at later stages due to lack of clinical symptoms. Early diagnosis of this condition is essential to effectively treat patients for better prognosis. A significant amount of advancement has been made in understanding the molecular nature of cancer in the past decade. Read More

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http://dx.doi.org/10.1016/j.mrrev.2018.03.002DOI Listing
November 2018
16 Reads

Signet Ring Cell Carcinoma of the Ampulla of Vater: A Rare Histopathological Variant.

Case Rep Gastroenterol 2018 Jan-Apr;12(1):194-201. Epub 2018 Apr 27.

Department of Surgery, Universitair Medisch Centrum Groningen, Groningen, The Netherlands.

Signet ring cell carcinoma (SRCC) of the ampulla of Vater is an extremely rare tumor. Our case describes a 45-year-old female presenting with jaundice and pruritus. Computed tomography, endoscopy, and endoscopic retrograde cholangiopancreatography showed a tumor of the ampulla of Vater without distant metastasis. Read More

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http://dx.doi.org/10.1159/000488903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968303PMC
April 2018
4 Reads

Differentiation of benign and malignant ampullary obstruction by multi-row detector CT.

Jpn J Radiol 2018 Aug 21;36(8):477-488. Epub 2018 May 21.

Department of Radiology, Thammasat University Hospital, 95 Moo 8, Phahon Yothin Road, Khlong Luang, Pathum Thani, 12110, Thailand.

Purpose: To determine useful CT parameters to differentiate ampullary carcinomas from benign ampullary obstruction.

Materials And Methods: This study included 93 patients who underwent abdominal CT, 31 patients with ampullary carcinomas, and 62 patients with benign ampullary obstruction. Two radiologists independently evaluated CT parameters then reached consensus decisions. Read More

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http://dx.doi.org/10.1007/s11604-018-0746-zDOI Listing
August 2018
14 Reads

Gangliocytic Paraganglioma with Carcinoma of the Ampulla of Vater.

Intern Med 2018 Sep 18;57(18):2663-2668. Epub 2018 May 18.

Department of Gastroenterology, Saitama Medical Center, Jichi Medical University, Japan.

The patient was a "73" -year-old woman who visited our hospital with the chief complaint of weight loss. Upper gastrointestinal endoscopy revealed an enlarged ampulla of Vater, and a biopsy led to a diagnosis of Group "4" gastric carcinoma; suspicious of adenocarcinoma. There were no findings suggesting invasion into the muscle layer of duodenum, despite tumor mass formation being observed in the sphincter of Oddi. Read More

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http://dx.doi.org/10.2169/internalmedicine.0464-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191592PMC
September 2018
5 Reads

Endoscopic papillectomy of benign ampullary lesions: Outcomes from a multicenter study.

Turk J Gastroenterol 2018 05;29(3):325-334

Division of Gastroenterology and Hepatology, Ankara High Speciality Training and Research Hospital, Ankara, Turkey.

Background/aims: Endoscopic papillectomy (EP) has emerged as an alternative to surgery in the management of ampullary lesions. The aim of this study is to evaluate feasibility, efficacy, safety, outcome, and impact of EP in the management of benign ampullary lesions.

Materials And Methods: This is a multicenter, retrospective study of 44 patients who had EP of benign ampullary lesions. Read More

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http://dx.doi.org/10.5152/tjg.2018.17378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284660PMC
May 2018
17 Reads

Total robotic surgery for pancreaticoduodenectomy combined with rectal cancer anterior resection: A case report and literature review.

Medicine (Baltimore) 2018 May;97(19):e0540

The First Affiliated Hospital of NanChang University, Gastrointestinal Surgery, NanChang, China.

Rationale: Synchronous double malignancies, including carcinoma of the ampulla of Vater and rectal carcinoma, are generally uncommon occurrences in the gastrointestinal tract.

Patient Concerns: The present study report a case of a 37-year-old man who was incidentally found to suffer from carcinoma of the ampulla of Vater and rectal carcinoma.

Diagnoses: The duodenoscopy was performed and revealed an ulcerated and bulky ampulla of Vater, the biopsy from which revealed a moderate-differentiated adenocarcinoma, A local hospital colonoscopy confirmed a tumor located in rectal 7 cm from the anal margin and biopsy-confirmed poorly differentiated adenocarcinoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000010540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959404PMC
May 2018
4 Reads

Intraobserver and Interobserver Variability in the Assessment of Dysplasia in Ampullary Mucosal Biopsies.

Am J Surg Pathol 2018 Aug;42(8):1095-1100

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.

Endoscopic mucosal biopsies of the ampulla of Vater (AmpBx) are obtained to histologically assess for dysplasia or carcinoma. However, biopsy material is often scant and a host of factors can induce histologic changes that pose diagnostic challenges. We sought to investigate observer variability in interpretation of AmpBx and the impact clinical data may have on diagnostic interpretation. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001079DOI Listing
August 2018
6 Reads

MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions.

Pathol Res Pract 2018 Jun 1;214(6):835-839. Epub 2018 May 1.

Department of Medicine (DIMED), University of Padua, Padua, PD, Italy. Electronic address:

Poor information is available on the molecular landscape characterizing the carcinogenetic process leading to ampullary carcinoma. MiR-21 is one of the most frequently up-regulated miRNAs in pancreatic adenocarcinoma, a tumor sharing similar molecular features with ampullary adenocarcinomas (AVCs), above all with the pancreatic-biliary type. We profiled, by in situ hybridization (ISH), miR-21 expression in a series of 26 AVCs, 50 ampullary dysplastic lesions (35 low-grade [LG-IEN] and 15 high-grade [HG-IEN]) and 10 normal duodenal mucosa samples. Read More

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http://dx.doi.org/10.1016/j.prp.2018.04.018DOI Listing
June 2018
5 Reads

Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas.

PLoS One 2018 3;13(5):e0196235. Epub 2018 May 3.

Department of Oncology, University of Calgary, Calgary, Canada.

Introduction: Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due to fat infiltration in muscle (myosteatosis). The biological and clinical correlates to these features are poorly understood.

Methods: Clinical characteristics and outcomes were studied in 123 patients who underwent pancreaticoduodenectomy for pancreatic or non-pancreatic periampullary adenocarcinoma and who had available preoperative CT scans. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196235PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933771PMC
August 2018
11 Reads

Cutaneous Metastasis of Adenocarcinoma of the Ampulla of Vater.

Am J Dermatopathol 2018 Oct;40(10):758-761

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.

Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001155DOI Listing
October 2018
2 Reads

Cauliflower-like Neoplasm of Duodenal Papilla in a Liver Transplant Recipient: What Should We Think and Do? A Case Report.

Transplant Proc 2018 Apr;50(3):925-929

Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Background: With the continuous improvement of liver transplantation technology, the survival rate of liver transplantation has been improved, but recurrent or de novo malignancy remains one of the major factors affecting the long-term survival of liver transplant recipients.

Case Report: A 45-year-old Chinese man had a plastic biliary stent placed on account of biliary anastomotic stenosis after 3 years of piggyback liver transplantation. He came to our hospital because of recurrent fever and jaundice for 2 weeks, and his carcinoembryonic antigen-199 had increased. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183004
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http://dx.doi.org/10.1016/j.transproceed.2018.01.016DOI Listing
April 2018
5 Reads

Efficacy and safety of endobiliary radiofrequency ablation for the eradication of residual neoplasia after endoscopic papillectomy: a multicenter prospective study.

Gastrointest Endosc 2018 Sep 13;88(3):511-518. Epub 2018 Apr 13.

Université Paris 5, INSERM U1016, Institut Cochin, Paris, France; Service de Gastroentérologie, Hôpital Cochin, Assistance publique hôpitaux de Paris, Paris, France.

Background And Aims: Endobiliary dysplasia may persist after endoscopic papillectomy. Intraductal radiofrequency ablation (ID-RFA) is a potential alternative to complementary surgery. The aim of this study was to evaluate the efficacy and safety of ID-RFA for the treatment of adenomatous intraductal residue after endoscopic papillectomy. Read More

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http://dx.doi.org/10.1016/j.gie.2018.04.2332DOI Listing
September 2018
40 Reads

The Answer Is in the Ampulla.

Gastroenterology 2018 Sep 11;155(3):e13-e14. Epub 2018 Apr 11.

Division of Gastroenterology, University of California, San Francisco, San Francisco, California.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183041
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http://dx.doi.org/10.1053/j.gastro.2018.04.006DOI Listing
September 2018
7 Reads

Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.

Cochrane Database Syst Rev 2018 Apr 6;4:CD011746. Epub 2018 Apr 6.

Department of Oncology, University of Calgary and Tom Baker Cancer Center, Calgary, Alberta, Canada, T2N 4N1.

Background: Biliary tract cancers are a group of rare heterogeneous malignant tumours. They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas. Surgery remains the optimal modality of therapy leading to long-term survival for people diagnosed with resectable biliary tract carcinomas. Read More

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http://dx.doi.org/10.1002/14651858.CD011746.pub2DOI Listing
April 2018
7 Reads
1 Citation

A Rare Case of Ampullary Goblet Cell Carcinoid.

Intern Med 2018 Sep 30;57(17):2489-2496. Epub 2018 Mar 30.

Departments of Gastroenterology, Aichi Cancer Center Hospital, Japan.

An asymptomatic 70-year-old woman was referred to our hospital because of liver enzyme elevation. Enhanced abdominal computed tomography demonstrated a small, round-shaped tumor with dilation of the common bile duct and main pancreatic duct. A biopsy specimen from the papilla showed mucin-containing cells that were positive for endocrine markers on immunohistochemical staining. Read More

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http://dx.doi.org/10.2169/internalmedicine.0516-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172535PMC
September 2018
2 Reads

Nomograms predict long-term survival for patients with periampullary adenocarcinoma after pancreatoduodenectomy.

BMC Cancer 2018 03 27;18(1):327. Epub 2018 Mar 27.

Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.

Background: The prognosis of patients with periampullary adenocarcinoma after pancreatoduodenectomy is diverse and not yet clearly illustrated. The aim of this study was to develop a nomogram to predict individual risk of overall survival (OS) and progression-free survival (PFS) in patients with periampullary adenocarcinoma after pancreatoduodenectomy.

Methods: A total of 205 patients with periampullary adenocarcinoma after pancreatoduodenectomy were retrospectively included. Read More

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http://dx.doi.org/10.1186/s12885-018-4240-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870913PMC
March 2018
8 Reads

The prognostic impact of differentiation at the invasive front of biliary tract cancer.

J Surg Oncol 2018 May 24;117(6):1278-1287. Epub 2018 Mar 24.

Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Chiba, Japan.

Background: The invasive front of tumor can provide prognostic information in many cancers. We investigated the prognostic morphological factors at the invasive front including tumor differentiation (Dif ) and tumor budding (Bud) in biliary tract cancer (BTC).

Methods: The resected specimen from the 299 BTC patients were examined. Read More

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http://dx.doi.org/10.1002/jso.24946DOI Listing
May 2018
13 Reads

[Adenocarcinoma of the ampulla of Vater revealed by prurigo].

Pan Afr Med J 2017 18;28:154. Epub 2017 Oct 18.

Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.

Chronic prurigo may reveal several internal diseases. Its association with a solid neoplasia is rare. We report an exceptional case of chronic prurigo revealing surgically curable adenocarcinoma of the ampulla of Vater. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.154.13846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851668PMC
April 2018
3 Reads

Adenosquamous carcinoma of the bile duct: a population-based study.

Cancer Manag Res 2018 7;10:439-446. Epub 2018 Mar 7.

Department of Medical Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Introduction: Adenosquamous carcinoma (ASC) of the bile duct is a rare diagnosis with poorly understood clinicopathological characteristics and disease progression, so identification of the features associated with ASC patient survival is warranted.

Materials And Methods: A population cohort study was performed using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database for patients with histological diagnoses of ASC of the bile duct from 1973 to 2013.

Results: A total of 106 patients with ASC of the bile duct were included (mean age 68. Read More

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http://dx.doi.org/10.2147/CMAR.S144850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846297PMC
March 2018
7 Reads

Impact of preoperative endoscopic cholangiography and biliary drainage in Ampulla of Vater cancer.

Surg Oncol 2018 Mar 30;27(1):82-87. Epub 2017 Dec 30.

Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Keimyung University School of Medicine, Dongsan Medical Center, 56 Dalsungro, Junggu, Daegu City, Republic of Korea.

Background: Ampulla of Vater (AOV) carcinoma is a rare malignancy but has a relatively good prognosis. The aims of this study were to determine the clinicopathologic factors associated with survival and disease recurrence in patients with AOV cancer, focusing on the impact of preoperative endoscopic retrograde cholangiopancreatography (ERCP) and type of biliary drainage (endoscopic retrograde biliary drainage [ERBD] or percutaneous transhepatic biliary drainage [PTBD]).

Methods: We retrospectively reviewed the medical records of 80 patients who underwent curative resection for AOV cancer at a single institution between 1995 and 2015. Read More

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http://dx.doi.org/10.1016/j.suronc.2017.12.002DOI Listing
March 2018
9 Reads

Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer.

World J Surg Oncol 2018 Mar 14;16(1):56. Epub 2018 Mar 14.

Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK.

Background: Expression of the dimeric M2 isoenzyme of pyruvate kinase, termed Tumor M2-PK, is increased in some human cancers. This study evaluates the potential role of pre-operative Tumor M2-PK as a marker of prognosis in patients with pancreatic malignancy.

Methods: Seventy-three consecutive patients with a clinical diagnosis of pancreatic or peri-ampullary cancer were enrolled. Read More

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http://dx.doi.org/10.1186/s12957-018-1360-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853155PMC
March 2018
5 Reads