2,596 results match your criteria Carcinoma of the Ampulla of Vater


Study Protocol of the ESAP Study: Endoscopic Papillectomy vs. Surgical Ampullectomy vs. Pancreaticoduodenectomy for Ampullary Neoplasm-A Pancreas2000/EPC Study.

Front Med (Lausanne) 2020 6;7:152. Epub 2020 May 6.

Department of Digestive, Hepatobiliary and Endocrine Surgery, Paris Descartes University, Cochin Hospital, Paris, France.

Lesions of the Ampulla of Vater are a rare condition and represent <10% of peri-ampullary neoplasms. Nevertheless, ampullary adenomas have the potential for malignant transformation to ampullary carcinomas by an adenoma-to-carcinoma sequence. Thus, adequate patient selection and complete resection (R0) of non-invasive ampullary lesions either by endoscopic papillectomy (EP), surgical ampullectomy (SA), or pancreaticoduodenectomy (PD) is essential. Read More

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http://dx.doi.org/10.3389/fmed.2020.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218136PMC

[Comparative analysis of radical surgical treatment of periampullary tumors].

Khirurgiia (Mosk) 2020 (4):24-29

Syzganov National Research Centre of Surgery, Almaty, Republic of Kazakhstan.

Objective: Retrospective analysis of patients with periampullary tumors undergoing pancreatoduodenectomy.

Material And Methods: A retrospective review included 48 patients with resectable periampullary tumors. Patients were divided into two groups according to the localization of cancer. Read More

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http://dx.doi.org/10.17116/hirurgia202004124DOI Listing

Benefits of F-FDG PET/CT for the preoperative characterisation or staging of disease in the ampullary and duodenal papillary.

Eur Radiol 2020 Apr 28. Epub 2020 Apr 28.

Nanfang PET Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, Guangdong Province, China.

Objectives: Diagnosing ampullary and duodenal papillary carcinomas (ADPCs) is challenging. In the present study, we investigated the application value of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in the preoperative evaluation of these tumours.

Methods: F-FDG PET/CT images of 58 patients with ADPC and 28 patients with benign disease were retrospectively analysed. Read More

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http://dx.doi.org/10.1007/s00330-020-06864-zDOI Listing

Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States.

HPB (Oxford) 2020 Apr 18. Epub 2020 Apr 18.

Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Drive, Stanford, CA, 94305, USA. Electronic address:

Background: Signet ring cell carcinoma (SRCC) of the ampulla of Vater is poorly understood, with approximately 22 reported cases. Our study sought to create a comprehensive review of cases in the United States.

Methods: We used the Surveillance, Epidemiology, and End Results Program to collect all cases of ampullary adenocarcinoma diagnosed between 2010 and 2015. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.03.024DOI Listing

Prognostic significance of stem cell/ epithelial-mesenchymal transition markers in periampullary/pancreatic cancers: FGFR1 is a promising prognostic marker.

BMC Cancer 2020 Mar 14;20(1):216. Epub 2020 Mar 14.

Department of Hospital Pathology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 07345, Republic of Korea.

Background: Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to cancer stem cells and epithelial-mesenchymal transition (EMT) such as octamer transcription factor-4 (Oct4) and fibroblast growth factor receptor 1 (FGFR1) respectively, have been proposed as new promising markers in other solid cancers. Read More

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http://dx.doi.org/10.1186/s12885-020-6673-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071628PMC
March 2020
3.362 Impact Factor

[Long-Term Survival after Surgical Treatment of Neuroendocrine Carcinoma of the Ampulla of Vater-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2586-2588

Dept. of Surgery, Toyonaka Municipal Hospital.

A 60s man underwent upper gastrointestinal endoscopy at a regular medical check-up without symptoms, which showed an ulcerative region in the duodenal ampulla, measuring 3 cm in diameter. He was diagnosed with poorly differentiated adenocarcinoma on biopsy and referred to our hospital. Abdominal contrast-enhanced CT scan revealed an enhanced-ulcerative tumor, measuring 3 cm, at the duodenal ampulla. Read More

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December 2019

[A Case of Liver Metastases of Ampullary Carcinoma with Clinical Complete Response Treated with Gemcitabine plus Cisplatin].

Gan To Kagaku Ryoho 2019 Dec;46(13):2357-2359

Dept. of Surgery, Kansai Rosai Hospital.

We report a case of liver metastases of ampullary carcinoma that achieved clinical complete response after gemcitabine plus cisplatin(GC)combination chemotherapy. A 69-year-old man with obstructive jaundice was diagnosed with ampullary carcinoma and underwent laparoscopic pancreaticoduodenectomy. Postoperative histopathological examination revealed pT3aN0M0, Stage ⅡA adenocarcinoma of the papilla of Vater. Read More

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December 2019

Primary malignant pericardial tumour in Lynch syndrome.

BMC Cancer 2020 Mar 6;20(1):191. Epub 2020 Mar 6.

Department of Experimental, Diagnostic and Specility Medicine - DIMES- Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Background: This case represents the first report of malignant primary cardiac tumour in a patient with Lynch Syndrome associated with MSH2 pathogenic variant.

Case Presentation: A 57-year-old woman with previous ovarian cystadenocarcinoma was admitted to the emergency room for hematic pericardial effusion. Multimodal diagnostic imaging revealed two solid pericardial vascularized masses. Read More

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http://dx.doi.org/10.1186/s12885-020-6677-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059379PMC

Acquired Hemophilia in an Elderly Patient with Carcinoma of the Ampulla of Vater.

Case Rep Oncol 2020 Jan-Apr;13(1):1-6. Epub 2020 Jan 13.

Department of Medical Oncology, University of Ioannina, Ioannina, Greece.

Acquired hemophilia is a rare autoimmune bleeding disorder related to the production of autoantibodies that inhibit clotting factor VIII or IX. The underlying cause can be autoimmune disease, malignancy, pregnancy, or medications, but it is most commonly idiopathic. Here we present the case of an 81-year-old patient with locoregionally relapsed periampullary carcinoma who presented with soft tissue hematoma and an abnormally elevated activated partial thromboplastin time (aPTT) in the presence of a normal prothrombin time. Read More

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http://dx.doi.org/10.1159/000504338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036531PMC
January 2020

MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes.

Ann Surg Oncol 2020 Feb 27. Epub 2020 Feb 27.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Microsatellite instability (MSI) has emerged as a predictive biomarker for immune checkpoint inhibitor therapy. Cancer heterogeneity represents a potential obstacle for the analysis of predicitive biomarkers. MSI has been reported in pancreatic cancer, but data on the possible extent of intratumoral heterogeneity are lacking. Read More

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http://dx.doi.org/10.1245/s10434-020-08209-yDOI Listing
February 2020

A Metastatic Neuroendocrine Eyelid Carcinoma Originating From the Ampulla of Vater.

Ophthalmic Plast Reconstr Surg 2020 Feb 7. Epub 2020 Feb 7.

Department of Pathology, National Cancer Center, Geonggi-do, Republic of Korea.

Tumor metastasis to the eyelids is very rare. The authors report the first case of a neuroendocrine tumor that originated from the ampulla of Vater in the gastrointestinal tract and metastasized to the eyelid. The patient with a hospice care was referred to the authors' eye clinic after presenting with a palpable mass on the left eyelid and blinking discomfort. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001609DOI Listing
February 2020

Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies.

Clin J Gastroenterol 2020 Jan 24. Epub 2020 Jan 24.

Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Yamagata, 990-8595, Japan.

Signet-ring cell carcinoma of the ampulla of Vater is a rare tumor. A 74-year-old woman presented with epigastric pain and was diagnosed with cholangitis. Her liver enzyme levels were elevated. Read More

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http://dx.doi.org/10.1007/s12328-020-01097-5DOI Listing
January 2020

Influence of bile contamination for patients who undergo pancreaticoduodenectomy after biliary drainage.

World J Gastroenterol 2019 Dec;25(47):6847-6856

Departments of Gastroenterological Surgery, Kagawa University, Kita-gun, Kagawa 761-0793, Japan.

Background: The influence of bile contamination on the infectious complications of patients undergoing pancreaticoduodenectomy (PD) has not been thoroughly evaluated.

Aim: To evaluate the effect of preoperative biliary drainage and bile contamination on the outcomes of patients who undergo PD.

Methods: The database of 4101 patients who underwent PD was reviewed. Read More

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http://dx.doi.org/10.3748/wjg.v25.i47.6847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931003PMC
December 2019

Development and validation of a nomogram for predicting overall survival of node-negative ampullary carcinoma.

J Surg Oncol 2020 Mar 26;121(3):518-523. Epub 2019 Dec 26.

Department of Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: The accuracy of the current staging system for predicting the overall survival (OS) of patients with ampullary carcinoma (AC) is still unsatisfactory, especially in node-negative (N0) patients. We aimed at establishing a nomogram to accurately predict OS in N0 AC.

Methods: This study enrolled 697 N0 AC patients from the Surveillance, Epidemiology, and End Results database (design cohort [DC], n = 697) and the First Affiliated Hospital of Sun Yat-sen University (validation cohort [VC], n = 112), who underwent surgical resection. Read More

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http://dx.doi.org/10.1002/jso.25816DOI Listing

Landscape of distant metastasis mode and current chemotherapy efficacy of the advanced biliary tract cancer in the United States, 2010-2016.

Cancer Med 2020 Feb 26;9(4):1335-1348. Epub 2019 Dec 26.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: The distant metastasis (DM) mode and treatment efficacies in the advanced biliary tract cancer (BTC) were obscure, and a credible evaluation is urgently needed.

Method: A total of 6348 advanced BTC patients (ICC, intrahepatic cholangiocarcinoma, n = 1762; PHCC, perihilar cholangiocarcinoma, n = 1103; GBC, gallbladder cancer, n = 2580; DCC, distal cholangiocarcinoma, n = 538; AVC, carcinoma of Vater ampulla, n = 365) were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) process was carried out for less bias. Read More

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http://dx.doi.org/10.1002/cam4.2794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013071PMC
February 2020

A review of changes to and clinical implications of the eighth TNM classification of hepatobiliary and pancreatic cancers.

Jpn J Clin Oncol 2019 Dec;49(12):1073-1082

Department of Medical Oncology, Kyorin University Faculty of Medicine, Japan.

Hepatobiliary and pancreatic cancers have poor outcomes. Clinical staging is useful for predicting survival and selecting treatment options. The 8th edition of tumor-node metastasis (TNM) was published in 2016 and came into effect from 2018. Read More

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http://dx.doi.org/10.1093/jjco/hyz150DOI Listing
December 2019

Stratification of Prognosis in Patients With Ampullary Carcinoma After Surgery by Preoperative Platelet-to-lymphocyte Ratio and Conventional Tumor Markers.

Anticancer Res 2019 Dec;39(12):6923-6929

First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Background/aim: The platelet-to-lymphocyte ratio (PLR) has recently been suggested as a new predictor of the prognosis in several carcinoma types. However, the clinical impact remains controversial in patients with ampullary carcinoma. Thus, the aim of this study was to investigate other useful biomarkers for identifying poor prognosis in patients with ampullary carcinoma. Read More

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http://dx.doi.org/10.21873/anticanres.13913DOI Listing
December 2019

Cancer-associated retinopathy in ampullary pancreatic cancer.

BMJ Case Rep 2019 Nov 10;12(11). Epub 2019 Nov 10.

Department of Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK.

A 64-year-old woman presented with bilateral visual loss with shimmering photopsias as the only clinical manifestation of an occult pancreatic ampullary adenocarcinoma causing duct dilatation. Abnormal electroretinograms led to suspicion of cancer-associated retinopathy (CAR), and CT of the abdomen showed an underlying pancreatic malignancy, detected with subclinical liver function tests following diagnosis of CAR. Biopsy showed a T2N0M0 ampullary adenocarcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2019-231444DOI Listing
November 2019

Very early recurrence following pancreaticoduodenectomy in patients with ampullary cancer.

Medicine (Baltimore) 2019 Nov;98(44):e17711

Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang-Si, Gyeonggi-Do.

We aimed to identify the factors for very early recurrence (within 6 months) of ampullary cancer following curative resection and to compare the immunohistochemical expression rate of various antibodies between the 2 main histologic subtypes of ampullary adenocarcinoma.In this retrospective study, the postoperative outcomes and clinicopathologic factors for very early recurrence that occurred in 14 of 93 patients who underwent pancreaticoduodenectomy (PD) for ampullary adenocarcinoma between January 2002 and August 2014 were analyzed. Thereafter, we identified the factors associated with very early recurrence following surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000017711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946574PMC
November 2019

Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma.

World J Gastroenterol 2019 Oct;25(40):6116-6128

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.

Background: For periampullary adenocarcinoma, the histological subtype is a better prognostic predictor than the site of tumor origin. Intestinal-type periampullary adenocarcinoma (IPAC) is reported to have a better prognosis than the pan-creatobiliary-type periampullary adenocarcinoma (PPAC). However, the classification of histological subtypes is difficult to determine before surgery. Read More

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http://dx.doi.org/10.3748/wjg.v25.i40.6116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824280PMC
October 2019

Poorly Cohesive (Signet Ring Cell) Carcinoma of the Ampulla of Vater.

Int J Surg Pathol 2020 May 15;28(3):236-244. Epub 2019 Oct 15.

Koç University, Istanbul, Turkey.

In the ampulla of Vater, carcinomas with "diffuse-infiltrative"/"signet ring cell" morphology, designated as "poorly cohesive carcinoma" (PCC) in the WHO classification, are very rare and poorly characterized. Nine cases with a classical PCC morphology constituting >50% of the tumor were identified. Mean age was 64. Read More

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http://dx.doi.org/10.1177/1066896919880968DOI Listing
May 2020
1 Read

Arterial resection and reconstruction in pancreatectomy: surgical technique and outcomes.

BMC Surg 2019 Oct 10;19(1):141. Epub 2019 Oct 10.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, People's Republic of China.

Background: The outcomes in patients with pancreatic or ampulla tumors remain unsatisfactory, especially with invasion into the hepatic artery (HA) or the superior mesenteric artery (SMA). In this setting, pancreatectomy combined with arterial resection and reconstruction may offer the possibility of an en-block resection with negative margins and acceptable morbidity and mortality.

Methods: A six year retrospective review of pancreatectomies performed at our institution, included 21 patients that underwent a pancreatectomy combined with arterial resection and reconstruction. Read More

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http://dx.doi.org/10.1186/s12893-019-0560-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785878PMC
October 2019
2 Reads

Tumor-specific Expression of Insulin-like Growth Factor II mRNA-binding Protein 3 Independently Predicts Worse Survival of Patients With Adenocarcinoma of the Ampulla of Vater.

Anticancer Res 2019 Sep;39(9):4947-4955

Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea

Background/aim: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocarcinoma of the ampulla of Vater (AVAC) has not been clarified to date.

Materials And Methods: The IMP3 expression status in 87 AVAC tissues was examined using immunostaining, and its association with various clinicopathological features and outcome of patients with AVAC was investigated. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13683DOI Listing
September 2019
4 Reads

Combination of CEUS and MRI for the diagnosis of periampullary space-occupying lesions: a retrospective analysis.

BMC Med Imaging 2019 09 2;19(1):77. Epub 2019 Sep 2.

Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou, 646000, Sichuan Province, China.

Background: The value of magnetic resonance imaging (MRI), contrast-enhanced ultrasound (CEUS), and the combination of CEUS and MRI (CCWM) for the diagnosis of periampullary space-occupying lesions (PSOL) was investigated.

Methods: A total of 102 patients diagnosed with PSOLs by surgery or biopsy were recruited retrospectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MRI, CEUS, and CCWM were analyzed. Read More

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http://dx.doi.org/10.1186/s12880-019-0376-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719361PMC
September 2019
1 Read

Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival.

J Gastrointest Cancer 2020 Mar;51(1):354-358

Department of Medicine, Division of Hematology/Oncology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://link.springer.com/10.1007/s12029-019-00297-8
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http://dx.doi.org/10.1007/s12029-019-00297-8DOI Listing
March 2020
5 Reads

The CT fish mouth ampulla sign: a highly specific finding in main duct and mixed intraductal papillary mucinous neoplasms.

Br J Radiol 2019 Nov 28;92(1103):20190461. Epub 2019 Aug 28.

Department of Radiology, Cambridge University Hospitals, Cambridge, United Kingdom.

Objective: Main duct and mixed intraductal papillary mucinous neoplasms (IPMN) are pre-malignant cystic pancreatic neoplasms associated with pancreatic duct dilatation. Distinguishing these from benign causes of pancreatic duct dilatation is important in order to allow appropriate surveillance or surgery. A patulous duodenal papilla with extrusion of mucus at endoscopic evaluation, the endoscopic fish mouth ampulla (E-FMA) sign, is reported in main duct and mixed IPMN. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20190461
Publisher Site
http://dx.doi.org/10.1259/bjr.20190461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849671PMC
November 2019
1 Read

Primary non-ampullary duodenal follicular lymphoma presenting with obstructive jaundice.

Clin J Gastroenterol 2020 Apr 10;13(2):214-218. Epub 2019 Aug 10.

Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.

Primary gastrointestinal follicular lymphoma is a rare disease. Follicular lymphoma does not cause any typical symptoms, although it usually shows the presence of multiple white granules on endoscopy. Few patients with follicular lymphoma present with the initial symptom of jaundice, which is usually associated with follicular lymphomas located in the papilla of Vater. Read More

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http://dx.doi.org/10.1007/s12328-019-01033-2DOI Listing
April 2020
4 Reads

High-Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater.

World J Surg Oncol 2019 Aug 9;17(1):140. Epub 2019 Aug 9.

Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Background: Expression of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be prognostic in several types of malignancies. However, the prognostic value of HMGB1 in ampullary cancer has not been studied.

Methods: Patients with adenocarcinoma of the ampulla of Vater who underwent R0 resection with pancreaticoduodenectomy between 2001 and 2011 were included in the present multi-institutional study. Read More

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http://dx.doi.org/10.1186/s12957-019-1675-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689175PMC
August 2019
3 Reads

Conversion surgery for initially unresectable carcinoma of the ampulla of Vater following pathological complete response to chemotherapy: a case report.

Surg Case Rep 2019 Jul 30;5(1):122. Epub 2019 Jul 30.

Department of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan.

Background: Carcinoma of the ampulla of Vater with distant metastases is regarded as unresectable. Systemic chemotherapy is basically the treatment of choice for such tumors.

Case Presentation: A 68-year-old woman was referred to our hospital and diagnosed with carcinoma of the ampulla of Vater with lymph node and multiple liver metastases. Read More

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http://dx.doi.org/10.1186/s40792-019-0680-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667511PMC
July 2019
3 Reads

Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.

Clin J Gastroenterol 2020 Feb 24;13(1):37-45. Epub 2019 Jul 24.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor composed of both adenocarcinoma and neuroendocrine components. Here, we report the case of a 75-year-old woman with ampullary MANEC. She visited a physician with the chief complaint of dark urine and was diagnosed with advanced jaundice. Read More

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http://dx.doi.org/10.1007/s12328-019-01009-2DOI Listing
February 2020
2 Reads

Laterally Spreading Adenocarcinoma Involving the Lower Bile Duct and Duodenum Expressing Heterogeneous Immunohistochemical Phenotypes.

Intern Med 2019 Nov 10;58(21):3087-3092. Epub 2019 Jul 10.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.

A 70-year-old man was admitted to our hospital due to elevated levels of hepatobiliary and pancreatic enzymes. Computed tomography showed contrast-enhanced mucosal hypertrophy from the duodenal papilla to the distal bile duct. Endoscopic examinations revealed a laterally spreading granular tumor and ampullary swelling. Read More

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http://dx.doi.org/10.2169/internalmedicine.2801-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875461PMC
November 2019

Cytologic features of pancreatobiliary neoplasm of duodenum.

Diagn Cytopathol 2019 Oct 5;47(10):1059-1062. Epub 2019 Jul 5.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine-New York Presbyterian Hospital, New York, New York.

Small intestinal adenomas are uncommon. Majority of these occur in the region of the ampulla of Vater. Adenomas of the ampulla can be further subdivided into two types-intestinal and pancreatobiliary. Read More

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http://dx.doi.org/10.1002/dc.24271DOI Listing
October 2019
5 Reads

Mutational profiling and immunohistochemical analysis of a surgical series of ampullary carcinomas.

J Clin Pathol 2019 Nov 29;72(11):762-770. Epub 2019 Jun 29.

Department of Pathology, Odense University Hospital, Odense, Denmark

Aims: Knowledge regarding the genetic features of ampullary carcinoma (AC) in European patients is limited. The utility of tumour markers for the establishment of a malignant diagnosis in biopsies from the ampullary region has not been fully elucidated. We aimed to describe the clinical, pathological, immunohistochemical (IHC) and genetic features of a Danish series of surgically resected ACs. Read More

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http://dx.doi.org/10.1136/jclinpath-2019-205912DOI Listing
November 2019
5 Reads

Safety and efficacy of a metal stent covered with a silicone membrane containing integrated silver particles in preventing biofilm and sludge formation in endoscopic drainage of malignant biliary obstruction: a phase 2 pilot study.

Gastrointest Endosc 2019 10 18;90(4):663-672.e2. Epub 2019 Jun 18.

Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Background And Aims: Membrane-covered self-expandable metal stents (SEMSs) have been developed to prolong the patency of stents by reducing tissue hyperplasia or tumor ingrowth. However, their effectiveness is attenuated by stent clogging as a result of biofilm formation on the inner surface of the membrane. The aim of this pilot study was to evaluate the efficacy and safety of SEMSs covered with a silicone membrane containing integrated silver particles (Ag-P) in malignant distal biliary obstruction. Read More

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http://dx.doi.org/10.1016/j.gie.2019.06.007DOI Listing
October 2019
4 Reads

Role of systemic inflammation in predicting the prognosis of ampulla of Vater carcinoma.

Surg Oncol 2019 Jun 15;29:33-40. Epub 2019 Feb 15.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Background: Ampulla of Vater carcinoma (AVC) is known to have better prognosis than other periampullary cancers that need pancreaticoduodenectomy for cure. However, up to 60% of patients who underwent curative resection develop recurrence, and the disease progresses rapidly in many patients. Inflammatory factors are known to be prognostic indicators related to poor overall survival (OS) in patients with other gastrointestinal cancers. Read More

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http://dx.doi.org/10.1016/j.suronc.2019.02.006DOI Listing
June 2019
8 Reads

[A Case of Ampullary Region Carcinoma in a Young Woman - A Case Report].

Gan To Kagaku Ryoho 2019 May;46(5):937-939

Dept. of Digestive Surgery, Kawaguchi Municipal Medical Center.

A 19-year-old woman with general fatigue who initially consulted a local hospital was referred to us for further examination of jaundice. Contrast-enhanced CT revealed apparent dilatation of the bile duct. Gastrointestinal endoscopy exhibited a tumor of the papilla of Vater(adenocarcinoma, tub2). Read More

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May 2019
11 Reads

MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma.

PLoS One 2019 31;14(5):e0217421. Epub 2019 May 31.

Department of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University (UNESP), Botucatu, SP, Brazil.

Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated pathways modulated by microRNAs (miRNAs) in PDAC and Vater ampulla (AMP) cancers. Global miRNA expression was identified in 19 PDAC, 6 AMP and 25 paired, histologically normal pancreatic tissues using the GeneChip 4. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217421PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544344PMC
February 2020
5 Reads

Persistent cholestasis resulting from duodenal papillary carcinoma in an adolescent male: A case report.

Medicine (Baltimore) 2019 May;98(22):e15708

Department of Infectious and Digestive Diseases, Children' Hospital of Hebei Province.

Rationale: Cholestasis in pediatric patients has diverse etiologies and can be broadly classified as intrahepatic or extrahepatic. The common causes of extrahepatic cholestasis are bile duct calculus, inflammation, or pancreatitis. Malignant tumor is a rare cause of bile ducts obstruction in adolescent. Read More

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http://dx.doi.org/10.1097/MD.0000000000015708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708834PMC
May 2019
8 Reads

ASO Author Reflections: The Accurate Prognostic Evaluation and Optimal Treatment Strategy for Ampulla of Vater Carcinoma.

Ann Surg Oncol 2019 12 21;26(Suppl 3):621-622. Epub 2019 May 21.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Centre, Sunto-Nagaizumi, Shizuoka, Japan.

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http://dx.doi.org/10.1245/s10434-019-07465-xDOI Listing
December 2019
10 Reads

Assessment of tumor heterogeneity: Differentiation of periampullary neoplasms based on CT whole-lesion histogram analysis.

Eur J Radiol 2019 Jun 30;115:1-9. Epub 2019 Mar 30.

Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. Electronic address:

Purpose: To investigate the utility of whole-lesion histogram analysis from multidetector computed tomography (MDCT) for discrimination of duodenal adenocarcinoma (DAC), pancreatic ductal adenocarcinoma (PDAC) and gastrointestinal stromal tumor (GIST) around the periampullary area.

Materials And Methods: 171 patients suspicious of periampullary tumors were examined by MDCT (arterial and venous phases) and treated with surgery. A total of 74 patients were finally included in this retrospective study (26 DACs, 20 PDACs, and 28 GISTs). Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.03.021DOI Listing
June 2019
6 Reads

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.

Cell Rep 2019 04;27(4):1265-1276.e4

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. These organoids derived from BTCs were cultured stably for >1 year and closely recapitulated the histopathology, gene expression, and genetic alterations evident in the primary tumors. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.088DOI Listing
April 2019
7 Reads

The effect of bilateral U-sutures in pancreaticojejunostomy in 75 consecutive cases.

Acta Chir Belg 2019 Jun;119(3):201-204

a Department of General Surgery , Affiliated Hospital of Yanbian University , Yanji , China.

Background: Various technical interventions have been suggested to decrease the frequency of postoperative pancreatic fistulas but the effect is not particularly satisfactory. We have analyzed our application of bilateral U-sutures in pancreaticojejunostomy.

Methods: The pancreatic stump is freed over approximately 2 cm, an appropriate diameter silicone catheter with 2-4 lateral holes was inserted into the remnant pancreatic duct (>2 mm in diameter is required) over 2-3 cm as a stent in 69 patients. Read More

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http://dx.doi.org/10.1080/00015458.2019.1610258DOI Listing
June 2019
11 Reads

Treatment of pembrolizumab-induced cutaneous lesions with ruxolitinib.

Eur J Cancer 2019 05 12;113:69-71. Epub 2019 Apr 12.

Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, 40402 Taiwan; College of Medicine, School of Medicine, China Medical University, Taichung, 40402 Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193021
Publisher Site
http://dx.doi.org/10.1016/j.ejca.2019.03.016DOI Listing
May 2019
16 Reads

Role of Immunohistochemistry in the Subtyping of Periampullary Adenocarcinoma.

Int J Surg Pathol 2019 Sep 3;27(6):598-608. Epub 2019 Apr 3.

1 Sir Ganga Ram Hospital, New Delhi, India.

. Subtyping of periampullary adenocarcinoma into intestinal and pancreatobiliary subtypes has emerged as an important prognostic factor with potential therapeutic implications. This distinction on morphology alone is often difficult with significant interobserver variability. Read More

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http://dx.doi.org/10.1177/1066896919837606DOI Listing
September 2019
16 Reads
0.961 Impact Factor

Impact of tumor site on the prognosis of small bowel adenocarcinoma.

Tumori 2019 Dec 1;105(6):524-528. Epub 2019 Apr 1.

Department of Molecular and Clinical Medicine, "Sapienza" University of Rome, Italy.

Background: Because of a lack of large-scale prospective studies there is no clear indication about the management of patients with small bowel adenocarcinoma (SBA). This study evaluated clinical outcome of patients diagnosed with SBA at our institution.

Methods: Clinicopathologic features, treatments, and clinical outcome of patients diagnosed with SBA between 2006 and 2017 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1177/0300891619839297DOI Listing
December 2019
14 Reads

Clinical outcomes of ampullary neoplasms in resected margin positive or uncertain cases after endoscopic papillectomy.

World J Gastroenterol 2019 Mar;25(11):1387-1397

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

Background: Endoscopic papillectomy (EP) for benign ampullary neoplasms could be a less-invasive alternative to pancreatoduodenectomy (PD). There are some problems and limitations with EP. The post-EP resection margins of ampullary tumors are often positive or uncertain because of the burning effect of EP. Read More

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http://dx.doi.org/10.3748/wjg.v25.i11.1387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429348PMC
March 2019
12 Reads

Rapid Drug Desensitization with Chemotherapeutics (Platins, Taxanes, and Others): A Single-Center Retrospective Study.

Int Arch Allergy Immunol 2019 20;179(2):114-122. Epub 2019 Mar 20.

Department of Chest Disease, Division of Allergy and Clinical Immunology, Ankara University School of Medicine, Ankara, Turkey,

Background: Rapid drug desensitization (RDD) induces a temporary tolerance to chemotherapeutics that induce hypersensitivity reactions (HSRs).

Purpose: Our objective is to report our experience with RDD to platins, taxanes, etoposide, doxorubicin, and irinotecan.

Methods: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to chemotherapeutics. Read More

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http://dx.doi.org/10.1159/000496745DOI Listing
July 2019
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The First Report of Laparoscopic Pancreaticoduodenectomy for Primary Duodenal Carcinoma in a Patient With Situs Inversus Totalis: Report of a Rare Case.

Surg Laparosc Endosc Percutan Tech 2019 Jun;29(3):e29-e33

Departments of Hepatobiliary and Pancreatic Surgery.

Background: Situs inversus (SI) is a rare congenital anomaly characterized by the transposition of thoracic and abdominal viscera. Laparoscopic pancreaticoduodenectomy (LPD) is increasingly used in patients with periampullar and pancreatic carcinomas. For patients with SI, LPD can be more complicated because of reversed anatomy and possible other associated anomalies that have not been expected before surgery. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000659DOI Listing
June 2019
6 Reads
0.938 Impact Factor

SpyGlass percutaneous transhepatic cholangioscopy-guided diagnosis of adenocarcinoma of the ampullary region in a patient with bariatric biliopancreatic diversion.

Hepatobiliary Pancreat Dis Int 2019 06 5;18(3):291-293. Epub 2019 Mar 5.

Department of Radiology, Radiology Unit, "Guglielmo da Saliceto" Hospital, Via Taverna 49, 29121 Piacenza, Italy.

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http://dx.doi.org/10.1016/j.hbpd.2019.03.002DOI Listing
June 2019
2 Reads