3,723 results match your criteria Carcinoma in Situ of the Urinary Bladder


Bladder Cancer Diagnosis and Follow-Up: The Current Status and Possible Role of Extracellular Vesicles.

Int J Mol Sci 2019 Feb 14;20(4). Epub 2019 Feb 14.

Flemish Institute for Technological Research (VITO), 2400 Mol, Belgium.

Diagnostic methods currently used for bladder cancer are cystoscopy and urine cytology. Cystoscopy is an invasive tool and has low sensitivity for carcinoma in situ. Urine cytology is non-invasive, is a low-cost method, and has a high specificity but low sensitivity for low-grade urothelial tumors. Read More

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http://dx.doi.org/10.3390/ijms20040821DOI Listing
February 2019

Long term oncologic outcome in patients with bladder cancer after radical cystectomy: Impact of carcinoma in situ in the era of neoadjuvant chemotherapy.

Int Urol Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Institute of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Purpose: To assess the impact of carcinoma in situ (CIS) on oncologic outcomes in patients who underwent radical cystectomy, with a focus on those who received neoadjuvant chemotherapy (NAC) including patients with down-staging to ≤ pT1cancer after chemotherapy.

Materials And Methods: All patients who underwent radical cystectomy for urothelial cancer with curative intent from 1985 to 2011 were included. The impact of CIS on recurrence free and overall survival (OS) was assessed in the whole cohort and a subgroup who received NAC as well as those with response to chemotherapy and down-staging to ≤ pT1. Read More

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http://dx.doi.org/10.1007/s11255-019-02087-4DOI Listing
January 2019
1.293 Impact Factor

[Instillation therapies for urothelial carcinoma of the upper urinary tract].

Urologe A 2019 Jan;58(1):25-29

Urologische Universitätsklinik, Inselspital, Universitätsspital Bern, 3010, Bern, Schweiz.

Traditionally, urothelial carcinoma of the upper urinary tract was a clear indication for radical nephroureterectomy with bladder cuff excision. It has been shown that in well-selected patients and depending on tumor stage, a kidney-sparing approach can be pursued with good oncological outcome and equivalent to the radical approach. The prevention of local and bladder recurrences is an important factor. Read More

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http://link.springer.com/10.1007/s00120-018-0830-0
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http://dx.doi.org/10.1007/s00120-018-0830-0DOI Listing
January 2019
4 Reads

[Organ preservation in cancer of the upper urinary tract].

Authors:
F Vom Dorp

Urologe A 2019 Jan;58(1):22-24

Helios Klinikum Duisburg, Grunewaldstraße 96, 47053, Duisburg, Deutschland.

Urothelial carcinoma of the upper urinary tract is a rare disease. Tumor biology is comparable to transitional cell carcinomas of the bladder. Local tumor control is much more difficult to achieve in the upper urinary tract than in the bladder. Read More

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http://dx.doi.org/10.1007/s00120-018-0831-zDOI Listing
January 2019

Bladder health in patients treated with BCG instillations for T1G2-G3 bladder cancer - a follow-up five years after the start of treatment.

Scand J Urol 2019 Jan 8:1-8. Epub 2019 Jan 8.

a Cancer Theme, Patient Area Pelvic Cancer , Karolinska University Hospital , Stockholm , Sweden.

Objective: Investigate symptoms and how they affect daily life in patients with Non-Muscle Invasive Bladder Cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG) instillations.

Materials And Methods: Patients treated with BCG were included. After an initial transurethral resection (TURB) followed by a second-look resection, the patients were given an induction course with BCG for 6 weeks followed by maintenance therapy for 2 years. Read More

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http://dx.doi.org/10.1080/21681805.2018.1538162DOI Listing
January 2019

Condyloma Acuminata Presenting as Isolated Papillary Lesions in the Prostatic Urethra.

Am J Case Rep 2018 Dec 22;19:1522-1525. Epub 2018 Dec 22.

Department of Pathology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

BACKGROUND A condyloma acuminatum is a sexually transmitted, human papillomavirus (HPV) associated, neoplasm. In men, it is predominantly found on external genitalia and rarely progresses more proximally than the distal penile urethra. Condyloma acuminata of the prostatic urethra are rare and are usually seen as an extension of, or in association with external lesions. Read More

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http://dx.doi.org/10.12659/AJCR.911682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320550PMC
December 2018
4 Reads

Editorial Comment.

Authors:
Georgios Gakis

J Urol 2019 01;201(1):54-55

Department of Urology and Pediatric Urology, University Hospital of Würzburg, Julius-Maximillians University, Würzburg, Germany.

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http://dx.doi.org/10.1097/01.ju.0000550123.08098.adDOI Listing
January 2019
1 Read

Editorial Comment.

J Urol 2019 01;201(1):54

Department of Urology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1097/01.ju.0000550122.69979.70DOI Listing
January 2019
1 Read

The history of urologic pathology: an overview.

Histopathology 2019 Jan;74(1):184-212

Indiana University Medical Center, Indianapolis, IN, USA.

This article begins with the testis and a legendary figure, Sir Astley Cooper, who wrote an early text on the organ. The early 20th century saw the first major development, the description of the seminoma by the French investigator Maurice Chevassu, but the pace of knowledge did not accelerate until after World War II with a major article from the Armed Forces Institute of Pathology (AFIP) by Nathan B. Friedman and Robert A. Read More

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http://doi.wiley.com/10.1111/his.13753
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http://dx.doi.org/10.1111/his.13753DOI Listing
January 2019
8 Reads

Precursor lesions of the urinary bladder.

Authors:
Jesse K McKenney

Histopathology 2019 Jan;74(1):68-76

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

The classification of neoplastic precursor lesions in the urinary tract has evolved slowly with the gradual accumulation of clinicopathological data. Current nomenclature was codified most recently by the 2016 WHO classification, which is based on primary data with clinical outcome, consensus group statements and considerations of practical utility in routine diagnosis. This review discusses precursor lesions of urothelial, squamous and glandular lineage. Read More

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http://dx.doi.org/10.1111/his.13762DOI Listing
January 2019
1 Read

Novel nomograms to predict recurrence and progression in primary non-muscle-invasive bladder cancer: validation of predictive efficacy in comparison with European Organization of Research and Treatment of Cancer scoring system.

World J Urol 2018 Dec 10. Epub 2018 Dec 10.

Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Purpose: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC).

Methods: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression. Read More

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http://link.springer.com/10.1007/s00345-018-2581-3
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http://dx.doi.org/10.1007/s00345-018-2581-3DOI Listing
December 2018
10 Reads

Patterns of Urachal Remnant Involvement by Urothelial Carcinoma: Intraluminal Noninvasive Spread can Mimic a Deep-seated Bladder Invasion.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Departments of Pathology.

Benign urachal remnants can be encountered in the adult urinary bladder and it is recognized that these can uncommonly give rise to urachal urothelial carcinoma. However, urachal remnants containing urothelial carcinoma incidentally encountered in cystectomies for bladder cancer has not been previously described. Herein, we present 8 adult bladder cancer cystectomies with incidental urachal remnants containing urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001192DOI Listing
November 2018
3 Reads

Comparison of urinary cytology and fluorescence in situ hybridization in the detection of urothelial neoplasia: An analysis of discordant results.

Diagn Cytopathol 2018 Nov 12. Epub 2018 Nov 12.

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: We examine the performance of cytology and FISH in the detection of urothelial carcinoma (UC), and explore the reasons for discrepant results, and potential clinical implications.

Methods: Urine samples from 89 patients were prospectively collected for simultaneous cytology and UroVysion FISH, and results correlated with concurrent biopsies and/or clinical or histologic follow-up data. Corresponding tissue biopsies, where available, were also evaluated by FISH. Read More

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http://dx.doi.org/10.1002/dc.24108DOI Listing
November 2018
2 Reads

Intravesical Radiofrequency-Induced Chemohyperthermia for Carcinoma of the Urinary Bladder: A Retrospective Multicentre Study.

Bladder Cancer 2018 Oct 29;4(4):365-376. Epub 2018 Oct 29.

Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

Objective: To examine the effect of intravesical radiofrequency-induced chemohyperthermia (RF-CHT) in carcinoma (CIS) patients overall and split according to previously received therapy.

Methods: CIS patients that underwent an induction and maintenance phase of≥6 RF-CHT instillations, and had either pathology or cystoscopy plus cytology available at 6 months of follow-up were retrospectively included. Complete response (CR), recurrences, cystectomy-free rate, overall survival (OS), and adverse events were evaluated. Read More

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http://dx.doi.org/10.3233/BLC-180187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218119PMC
October 2018
1 Read

[The REVELA13 observatory to study new cases of bladder tumor among women living in Bouches-du-Rhône county].

Prog Urol 2018 Dec 10;28(16):935-941. Epub 2018 Oct 10.

Service d'urologie et de transplantation rénale, hôpital de la Conception, 147, boulevard Baille, 13005 Marseille, France; Aix Marseille université, 13005 France.

Introduction: The REVELA13 observatory is a unique epidemiological tool listing the new cases of kidney tumors, bladder tumors and acute leukaemias in the Bouches-du-Rhône county (France). Aim was to exploit for the first time data from this observatory regarding new cases of bladder tumors≥T1 in women from 2012 to 2014.

Materials: This epidemiological study was observational and descriptive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087183052
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http://dx.doi.org/10.1016/j.purol.2018.09.004DOI Listing
December 2018
10 Reads

UCA1 overexpression is associated with less aggressive subtypes of bladder cancer.

Oncol Rep 2018 Nov 10;40(5):2497-2506. Epub 2018 Sep 10.

Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), B‑1070 Brussels, Belgium.

Non‑coding RNAs (ncRNAs) have been shown to serve important roles in carcinogenesis via complex mechanisms, including transcriptional and post‑transcriptional regulation, and chromatin interactions. Urothelial carcinoma‑associated 1 (UCA1), a long ncRNA, was recently shown to have tumorigenic properties in urothelial bladder cancer (UBC), as demonstrated by enhanced proliferation, migration, invasion and therapy resistance of UBC cell lines in vitro. These in vitro findings suggested that UCA1 is associated with aggressive tumor behavior and could have prognostic implications in UBC. Read More

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http://dx.doi.org/10.3892/or.2018.6697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151879PMC
November 2018
1 Read

Recurrent Urinary Tract Infections in Females and the Overlap with Overactive Bladder.

Curr Urol Rep 2018 Sep 13;19(11):94. Epub 2018 Sep 13.

Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Purpose Of Review: There are an estimated 33 million men and women with overactive bladder (OAB) in the USA. Despite the prevalence of OAB, it remains a frequently misdiagnosed condition. OAB has shared symptomatology with other common urologic conditions, namely recurrent urinary tract infections (UTIs). Read More

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http://link.springer.com/10.1007/s11934-018-0839-3
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http://dx.doi.org/10.1007/s11934-018-0839-3DOI Listing
September 2018
37 Reads

Nasopharyngeal carcinoma with unusual metastasis to urinary bladder.

J Cancer Res Ther 2018 Jul-Sep;14(5):1160-1161

Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India.

Nasopharyngeal carcinoma (NPC) metastasizing to urinary bladder is an uncommon site. We report an interesting case of NPC, on follow-up, presenting with unusual urinary symptoms and mimicking a primary bladder cancer. Subsequent bladder cold cup biopsy and immunohistochemistry unfolded a metastasis of NPC, highlighting unexpected and a rare presentation. Read More

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http://www.cancerjournal.net/text.asp?2018/14/5/1160/204844
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http://dx.doi.org/10.4103/0973-1482.204844DOI Listing
October 2018
2 Reads

Diagnostic Advances in Urine Cytology.

Surg Pathol Clin 2018 Sep 13;11(3):601-610. Epub 2018 Jul 13.

Cleveland Clinic Foundation, Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

The utility of urine cytology has shifted from the identification of red blood cells, crystals, or parasites to its currently used role of detection of cancer cells exfoliated in urine samples. A variety of ancillary tests have been developed to complement the diagnostic ability of urine cytology. Furthermore, urine testing will continue to evolve as the pathogenesis of genitourinary tract diseases in depth is understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18759181183003
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http://dx.doi.org/10.1016/j.path.2018.06.001DOI Listing
September 2018
24 Reads

Prognostic Factors Related to Recurrence-Free Survival for Primary Carcinoma in situ of the Bladder after Bacillus Calmette-Guérin: A Retrospective Study.

Urol Int 2018 4;101(3):269-276. Epub 2018 Sep 4.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Introduction: Primary carcinoma in situ (P-CIS) of the bladder is rare and its clinical behavior and predictive features have not been well described. The purpose of this study was to evaluate the effects of various factors including angiotensin-2 converting enzyme inhibitors/angiotensin II receptor blockers (ACEIs/ARBs) on recurrence-free survival (RFS)-related prognosis in patients with P-CIS.

Materials And Methods: In our medical center, 5,945 patients were diagnosed with bladder cancer from January 1999 to January 2014. Read More

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http://dx.doi.org/10.1159/000492121DOI Listing
September 2018
14 Reads

Educational Case: Bladder Carcinoma In Situ.

Authors:
H James Williams

Acad Pathol 2018 Jan-Dec;5:2374289517719858. Epub 2018 Aug 14.

Department of Pathology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA.

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals. Read More

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http://dx.doi.org/10.1177/2374289517719858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096676PMC
August 2018
12 Reads

ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response?

PLoS One 2018 23;13(8):e0202965. Epub 2018 Aug 23.

Uropathology Group, Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany.

Bladder cancer therapy relies on aggressive treatments highlighting the need for new, targeted therapies with reduced side effects. SWI/SNF complexes are mutated in ~20% across human cancers and dependency of SWI/SNF-deficient tumors on EZH2 has been uncovered recently. To systematically dissect the frequency of genetic alterations in SWI/SNF complexes potentially contributing to their inactivation, mutations and copy number variations in 25 SWI/SNF subunit genes were analyzed making use of publicly available sequencing data for 408 muscle-invasive bladder carcinoma samples. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202965PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107234PMC
February 2019
1 Read

Diagnostic Value Comparison of Urothelium Carcinoma Among Urine Exfoliated Cells Fluorescent In Situ Hybridization (FISH) Examination, Computerized Tomography (CT) Scan, and Urine Cytologic Examination.

Med Sci Monit 2018 Aug 19;24:5788-5792. Epub 2018 Aug 19.

Department of Urinary Surgery, Hebei General Hospital, Shijiazhuang, Hebei, China (mainland).

BACKGROUND This study aimed to compare the clinical effectiveness of urine exfoliated cells FISH examination, CT scan, and urine cytologic examination on the diagnosis of upper urinary tract urothelium carcinoma with hematuresis symptom. MATERIAL AND METHODS A total of 30 patients with suspicious upper urinary tract urothelium carcinoma between Aug 2010 and Aug 2011 were enrolled, including 23 males and 7 females. All the subjects received urine exfoliated cells FISH examination, CT scan, and urine cytologic examination. Read More

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http://dx.doi.org/10.12659/MSM.910134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111772PMC
August 2018
2 Reads

Are there any metastases to the chest in non-muscle-invasive bladder cancer patients on follow-up computed tomography?

Int Urol Nephrol 2018 Oct 16;50(10):1771-1778. Epub 2018 Aug 16.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Purpose: The purpose of the study was to retrospectively determine whether there are metastases to the chest in patients with primary non-muscle-invasive urothelial carcinoma in the bladder on the follow-up computed tomography (CT).

Methods: We analyzed 328 patients with follow-up chest CT for urothelial carcinoma of the bladder diagnosed between January 2004 and September 2013. We divided patients into four groups: Ta (n = 74), T1 (n = 78), carcinoma in situ (CIS, n = 25), and ≥ T2 (n = 151). Read More

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http://dx.doi.org/10.1007/s11255-018-1952-4DOI Listing
October 2018
5 Reads

Prognostic Value of Concomitant Carcinoma In Situ in the Radical Cystectomy Specimen: A Systematic Review and Meta-Analysis.

J Urol 2019 01;201(1):46-53

Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria.

Purpose: We investigated the prognostic impact of concomitant carcinoma in situ in radical cystectomy specimens.

Materials And Methods: We performed a systematic review and meta-analysis using MEDLINE®, Scopus®, Web of Science™ and The Cochrane Library to identify eligible studies published until October 2017. Studies were eligible for analysis if they compared patients with concomitant carcinoma in situ in radical cystectomy specimens for bladder cancer to patients without concomitant carcinoma in situ to determine its value to prognosticate overall mortality, recurrence-free survival, cancer specific mortality and ureteral involvement using multivariable analysis. Read More

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http://dx.doi.org/10.1016/j.juro.2018.05.162DOI Listing
January 2019
6 Reads

Fluorescence in situ hybridization microscopic detection of Bacilli Calmette Guérin mycobacteria in aortic lesions: A case report.

Medicine (Baltimore) 2018 Jul;97(30):e11321

Microbiology Laboratory.

Rationale: To improve the diagnosis of life-threatening Bacilli Calmette Guérin (BCG) arterial aneurysm in patients treated by intravesical instillation of BCG vaccine as adjunctive therapy for non-muscular bladder carcinoma, is a life-threatening condition. Its diagnosis remains cumbersome.

Patient Concerns: One patient with a history of intravesical BCG installation presented with aortic aneurysm with routine microscopic examination after Ziehl-Neelsen staining remaining negative. Read More

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http://dx.doi.org/10.1097/MD.0000000000011321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078740PMC
July 2018
10 Reads

The effect of marital status on the survival of patients with bladder urothelial carcinoma: A SEER database analysis.

Medicine (Baltimore) 2018 Jul;97(29):e11378

Department of Urology, Subei People's Hospital of Jiangsu Province GClinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.

To identify whether marital status is associated with survival in patients with bladder urothelial carcinoma (UC). Using Surveillance, Epidemiology, and End Results population-based data, 133,846 patients diagnosed with bladder UC between 1988 and 2009 were identified. Kaplan-Meier methods and multivariable Cox regression models were used for survival analyses and evaluation of the association between marital status and survival, after controlling for gender, age, race, primary site, tumor (topography), lymph node, metastasis stage, pathological grading, and surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000011378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086512PMC
July 2018
1 Read

FDG-PET/CT for Assessing the Response to Neoadjuvant Chemotherapy in Bladder Cancer Patients.

Clin Genitourin Cancer 2018 10 31;16(5):360-364. Epub 2018 May 31.

Department of Urology, University of Minnesota, Minneapolis, MN.

Purpose: To determine the accuracy of F-fluorodeoxyglucose with positron emission tomography and computed tomography (FDG-PET/CT) scans in assessing the response to neoadjuvant chemotherapy (NAC) in patients with bladder cancer scheduled to undergo radical cystectomy (RC).

Patients And Methods: All patients treated at our center for muscle-invasive bladder cancer (MIBC) were counseled and offered NAC before RC. FDG-PET/CT scans were performed before the initiation of chemotherapy and after completion of the regimen. Read More

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http://dx.doi.org/10.1016/j.clgc.2018.05.008DOI Listing
October 2018
8 Reads

Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial.

Lancet 2018 06;391(10139):2525-2536

Department of Urology, Division of Urologic Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; CHRISTUS Santa Rosa Medical Center Hospital, San Antonio, TX, USA.

Background: Radical cystectomy is the surgical standard for invasive bladder cancer. Robot-assisted cystectomy has been proposed to provide similar oncological outcomes with lower morbidity. We aimed to compare progression-free survival in patients with bladder cancer treated with open cystectomy and robot-assisted cystectomy. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)30996-6DOI Listing
June 2018
19 Reads

High-Grade T1 on Re-Transurethral Resection after Initial High-Grade T1 Confers Worse Oncological Outcomes: Results of a Multi-Institutional Study.

Urol Int 2018 4;101(1):7-15. Epub 2018 Jul 4.

Department of Urology, Medical University of Vienna, Vienna, Austria.

Introduction: The aim of this multicenter study was to investigate the prognostic impact of residual T1 high-grade (HG)/G3 tumors at re-transurethral resection (TUR of bladder tumor) in a large multi-institutional cohort of patients with primary T1 HG/G3 bladder cancer (BC).

Patients And Methods: The study period was from January 2002 to -December 2012. A total of 1,046 patients with primary T1 HG/G3 and who had non-muscle invasive BC (NMIBC) on re-TUR followed by adjuvant intravesical Bacillus Calmette-Guerin (BCG) therapy with maintenance were included. Read More

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https://www.karger.com/Article/FullText/490765
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http://dx.doi.org/10.1159/000490765DOI Listing
January 2019
36 Reads

Identification of Carbonic Anhydrase IX as a Novel Target for Endoscopic Molecular Imaging of Human Bladder Cancer.

Cell Physiol Biochem 2018 27;47(4):1565-1577. Epub 2018 Jun 27.

Department of Urology, the Fourth Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.

Background/aims: Emerging novel optical imaging techniques with cancer-specific molecular imaging agents offer a powerful and promising platform for cancer detection and resection. White-light cystoscopy and random bladder biopsies remain the most appropriate but nonetheless suboptimal diagnostic technique for bladder cancer, which is associated with high morbidity and recurrence. However, white-light cystoscopy has intrinsic shortcomings. Read More

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https://www.karger.com/Article/FullText/490875
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http://dx.doi.org/10.1159/000490875DOI Listing
August 2018
18 Reads

[Usefulness of cold ureteral biopsy during radical cystectomy as a predictor of recurrence risk: Review of our series.]

Arch Esp Urol 2018 Jun;71(5):486-494

Servicio de Urología. Hospital Universitario Central de Asturias. Oviedo. Asturias. España.

Objectives: To evaluate the association of positive margins in the intraoperative biopsy during radical cystectomy (RC) with the risk of recurrence in the uretero-ileal anastomosis or upper urinary tract (UUT), and identify potential risk factors for positive ureteral margins.

Methods: A retrospective, descriptive study was performed in patients treated with radical cystectomy due to transitional cell carcinoma (TCC), who underwent a cold biopsy of the ureteral margin at the time of cystectomy. A descriptive analysis and frequency distribution was performed. Read More

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June 2018
28 Reads

Metric substage according to micro and extensive lamina propria invasion improves prognostics in T1 bladder cancer.

Urol Oncol 2018 08 5;36(8):361.e7-361.e13. Epub 2018 Jun 5.

Department of Surgical Oncology (Urology), Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany; Department of Urology, Erasmus MC Cancer Institute, Erasmus MC, Rotterdam, The Netherlands; Department of Surgical Oncology (Urology), University Health Network, Princess Margaret Cancer Center, University of Toronto, Toronto, Canada. Electronic address:

Background: Reliable prognosticators for T1 bladder cancer (T1BC) are urgently needed.

Objective: To compare the prognostic value of 2 substage systems for T1BC in patients treated by transurethral resection (TUR) and adjuvant bacillus Calmette-Guérin therapy.

Design, Setting, And Participants: The slides of 601 primary T1BCs from four institutes were reviewed by 2 uropathologists and substaged according to 2 classifications: metric substage according to T1 microinvasive (T1m-lamina propria invasion <0. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.05.007DOI Listing
August 2018
13 Reads

Commentary on "Prognostic effect of carcinoma in situ in muscle-invasive urothelial carcinoma patients receiving neoadjuvant chemotherapy."

Urol Oncol 2018 07 5;36(7):345. Epub 2018 Jun 5.

Background: Carcinoma in situ (CIS) is a poor prognostic finding in urothelial carcinoma. However, its significance in muscle-invasive urothelial carcinoma (MIUC) treated with neoadjuvant chemotherapy (NAC) is uncertain. We assessed the effect of CIS found in pretreatment transurethral resection of bladder tumor (TURBT) biopsies on the pathologic and clinical outcomes. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.05.003DOI Listing
July 2018
13 Reads

Commentary on "A novel treatment strategy for newly diagnosed high-grade T1 bladder cancer: Gemcitabine and cisplatin adjuvant chemotherapy-A single-institution experience."

Urol Oncol 2018 07 30;36(7):346-347. Epub 2018 May 30.

Background: Management of high-grade T1 (formerly T1G3) bladder cancer continues to be controversial. Should patients with T1G3 bladder cancer have an immediate radical cystectomy or should they receive intravesical bacillus Calmette-Guérin preserving bladder? Gemcitabine and cisplatin (GC) adjuvant chemotherapy may help to strike a balance between intravesical and early cystectomy. For purposes of this study, we continue to refer high-grade T1 lesion as "T1G3. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.05.012DOI Listing
July 2018
6 Reads

Blue light cystoscopy for the diagnosis of bladder cancer: Results from the US prospective multicenter registry.

Urol Oncol 2018 08 30;36(8):361.e1-361.e6. Epub 2018 May 30.

University of Minnesota, Minneapolis, MN.

Introduction: Blue light cystoscopy (BLC) using hexaminolevulinate (HAL/Cysview/Hexvix) has been previously shown to improve detection of non-muscle-invasive bladder cancer (NMIBC). Herein, we evaluated the detection of malignant lesions in a heterogenous group of patients in the real world setting and documented the change in risk category due to upstaging or upgrading.

Methods: Prospective enrollment during April 2014 to December 2016 of consecutive adult patients with suspected or known non-muscle-invasive bladder cancer based on prior cystoscopy or imaging, undergoing transurethral resection of bladder tumor at 9 different referral medical centers. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.04.013DOI Listing
August 2018
11 Reads

Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.

Hum Pathol 2018 Sep 12;79:57-65. Epub 2018 May 12.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:

Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68 years. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133751PMC
September 2018
23 Reads

miR-429 expression in bladder cancer and its correlation with tumor behavior and clinical outcome.

Kaohsiung J Med Sci 2018 Jun 2;34(6):335-340. Epub 2018 Mar 2.

Division of Urology, Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan; Department of Surgery, National Defense Medical Center, Taipei, Taiwan. Electronic address:

We previously showed that microRNA-429 (miR-429) played an important role in epithelial-mesenchymal transition (EMT) of urothelial cell carcinoma of the bladder. We herein evaluated the expression of miR-429 in bladder cancer and its potential relevance to clinicopathological characteristics and patient survival. Relative expression levels of miR-429 in surgical bladder cancer tissue specimens obtained from 76 patients with bladder cancer were measured by chromogenic in situ hybridization. Read More

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http://dx.doi.org/10.1016/j.kjms.2018.01.001DOI Listing
June 2018
1 Read

Comparison of 10-year overall survival between patients with G1 and G2 grade Ta bladder tumors.

Medicine (Baltimore) 2018 Apr;97(16):e0522

Department of Urology, University of Medicine and Pharmacy, Tirgu Mures, Romania.

To compare long-term overall survival (OS) in patients with G1 and G2 grade Ta bladder cancer after transurethral resection of bladder tumors (TURBTs). Secondary aim was to investigate clinical and pathologic prognostic factors for OS of Ta patients, except G3/high grade (HG).A total of 243 patients, retrospectively selected, with Ta nonmuscle invasive bladder cancer (NMIBC) underwent TURBT between January 2006 and December 2008 (median follow-up 109 months). Read More

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http://dx.doi.org/10.1097/MD.0000000000010522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916673PMC
April 2018
21 Reads

Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications.

Virchows Arch 2018 May 13;472(5):749-758. Epub 2018 Apr 13.

Institute of Pathology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.

The stratification of bladder cancer into luminal and basal tumors has recently been introduced as a novel prognostic system in patient cohorts of muscle-invasive bladder cancer or high-grade papillary carcinomas. Using a representative immunohistochemistry panel, we analyzed luminal and basal marker expression in a large case series (n = 156) of urothelial carcinoma in situ (CIS), a precancerous lesion that frequently progresses to muscle-invasive disease. The majority of CIS cases was characterized by a positivity for luminal markers (aberrant cytokeratin (CK) 20 85% (132/156), GATA3 median Remmele score (score of staining intensity (0-3) multiplied with percentage of positive cells (0-4)): 12, estrogen receptor (ER) β Remmele score > 2: 88% (138/156), human epidermal growth factor receptor 2 (Her2) Dako score 3+ 32% (50/156), Her2 Dako score 2+ 33% (51/156)), and marginal expression of basal markers (CK5/6+ 2% (3/156), CK14+ 1% (2/156)). Read More

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http://dx.doi.org/10.1007/s00428-018-2354-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978840PMC
May 2018
10 Reads

Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

Dis Markers 2018 30;2018:5823870. Epub 2018 Jan 30.

Department of Urology, Eberhard Karls University, Tuebingen, Germany.

Objectives: To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC).

Patients And Methods: The study comprised 758 urine samples either collected from the bladder ( = 373) or UUT ( = 385). All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy. Read More

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http://dx.doi.org/10.1155/2018/5823870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831978PMC
September 2018
37 Reads

Treatment of carcinoma in situ of the urinary bladder with an alpha-emitter immunoconjugate targeting the epidermal growth factor receptor: a pilot study.

Eur J Nucl Med Mol Imaging 2018 07 11;45(8):1364-1371. Epub 2018 Apr 11.

European Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, Karlsruhe, Germany.

Purpose: Patients with carcinoma in situ (CIS) of the bladder refractory to bacillus Calmette-Guérin (BCG) treatment are usually treated with cystectomy. Therefore, new treatment options with preservation of the urinary bladder are needed. The objective of the study was to investigate the feasibility, safety and efficacy of a novel targeted alpha-emitter immunotherapy for CIS after BCG treatment failure. Read More

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http://link.springer.com/10.1007/s00259-018-4003-6
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http://dx.doi.org/10.1007/s00259-018-4003-6DOI Listing
July 2018
16 Reads

Companied P16 genetic and protein status together providing useful information on the clinical outcome of urinary bladder cancer.

Medicine (Baltimore) 2018 Apr;97(15):e0353

Department of Pathology, Nanjing University Medical School affiliated Drum Tower Hospital, Nanjing.

SPEC P16/CEN3/7/17 Probe fluorescence-in-situ-hybridization (FISH) has become the most sensitive method in indentifying the urothelial tumors and loss of P16 has often been identified in low-grade urothelial lesions; however, little is known about the significations of other P16 genetic status (normal and amplification) in bladder cancer.We detected P16 gene status by FISH in 259 urine samples and divided these samples into 3 groups: 1, normal P16; 2, loss of P16; and 3, amplified P16. Meanwhile, p16 protein expression was measured by immunocytochemistry and we characterized the clinicopathologic features of cases with P16 gene status. Read More

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http://Insights.ovid.com/crossref?an=00005792-201804130-0004
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http://dx.doi.org/10.1097/MD.0000000000010353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908565PMC
April 2018
12 Reads

High expression of long noncoding RNA NORAD indicates a poor prognosis and promotes clinical progression and metastasis in bladder cancer.

Urol Oncol 2018 Jun 28;36(6):310.e15-310.e22. Epub 2018 Mar 28.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan Province, PR China. Electronic address:

Purpose: To explore the function of NORAD in bladder cancer (BC), and to verify whether NORAD could be used as a biomarker to determine preoperative presence of progression and lymph node metastasis. To our knowledge, it is the first study investigating NORAD and its implications in BC.

Methods: BC specimens of 90 patients underwent bladder cystectomy or transurethral resection between January 2012 to December 2016 were tested by fluorescence in situ hybridization. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.02.019DOI Listing
June 2018
4 Reads

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.

Urol Oncol 2018 06 27;36(6):311.e1-311.e13. Epub 2018 Mar 27.

Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, China. Electronic address:

Objectives: We recently determined that a novel oncogene, IPO11 from 5q12, participates in bladder cancer (BCa) progression. However, the biological function of IPO11 and the molecular mechanisms through which it contributes to BCa progression remain unclear. The aim of this study was to investigate the role of IPO11 in BCa aggressiveness and elucidate the molecular mechanisms underlying its effects in BCa. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.03.001DOI Listing
June 2018
11 Reads

Positive urinary fluorescence hybridization indicates poor prognosis in patients with upper tract urothelial carcinoma.

Oncotarget 2018 Mar 4;9(18):14652-14660. Epub 2018 Jan 4.

Department of Urology, Peking University First Hospital, Xicheng, Beijing, China.

Here, we evaluated the potential contribution of fluorescent in situ hybridization (FISH) as a prognostic risk factor of bladder recurrence and survival in patients with upper tract urothelial carcinoma (UTUC). A total of 159 UTUC patients were enrolled in this study from January 2012 to May 2016. The 159 voided urine samples before surgery were analyzed using the UroVysion kit to detect the copy numbers of chromosomes 3, 7, 17 and 9p21 (p16). Read More

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http://dx.doi.org/10.18632/oncotarget.24007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865697PMC
March 2018
14 Reads

Intravesical recurrence after bladder sparing treatment of small cell carcinoma of the bladder: Characteristics, treatment, and outcome.

Urol Oncol 2018 Jun 23;36(6):307.e1-307.e8. Epub 2018 Mar 23.

Department of urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.

Introduction: Small cell carcinoma of the bladder (SCCB) is a rare and lethal disease. Previously, we and others have reported a bladder sparing strategy with platinum-etoposide-based chemotherapy followed by radiotherapy of the bladder. Little is known on frequency and treatment of intravesical recurrence following this approach. Read More

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http://dx.doi.org/10.1016/j.urolonc.2018.02.015DOI Listing
June 2018
10 Reads

Iatrogenic pathology of the urinary bladder.

Semin Diagn Pathol 2018 Jul 14;35(4):218-227. Epub 2018 Mar 14.

Department of Pathology, University at Alabama Birmingham School of Medicine, Birmingham, AL, USA.

Intravesical immunotherapy, chemotherapy, and neoadjuvant systemic chemotherapy are among the most frequent therapeutic procedures to treat malignancies of the urinary bladder. These treatment modalities produce reactive morphologic changes in the urothelium that can mimic urothelial carcinoma in situ, urothelial dysplasia or true invasive urothelial neoplasia. Mitomycin C used after transurethral resection of bladder tumor to reduce recurrences, BCG intravesical immunotherapy to treat high risk non-muscle invasive bladder cancer and urothelial carcinoma in situ, and platinum-based systemic chemotherapy to improve post-cystectomy disease-specific survival some of the causes of therapy related atypia in urinary bladder. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.03.001DOI Listing
July 2018
8 Reads

A prolonged response to platinum-based therapy in a patient with metastatic urothelial carcinoma harboring a single rearranged and truncated NF2 gene.

Genes Chromosomes Cancer 2018 08 30;57(8):430-433. Epub 2018 Mar 30.

Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Tumor genome sequencing has become an invaluable resource in determining targets for new therapies. In this report, we describe the case of a patient with metastatic urothelial carcinoma with sarcomatoid features. Sarcomatoid differentiation is a rare histologic subtype that confers a more aggressive course. Read More

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http://dx.doi.org/10.1002/gcc.22537DOI Listing
August 2018
7 Reads