892,262 results match your criteria Carcinoma in Situ of the Urinary Bladder


[Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

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October 2018
1 Read

A Matched Analysis on the Prognostic Impact of Race on Survival Endpoints of Women with Early-Stage Endometrial Cancer.

Gynecol Obstet Invest 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan,

Objective: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.

Methods And Materials: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. Read More

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December 2018

An unusual presentation of papillary thyroid carcinoma in a pediatric patient: A case report.

Ear Nose Throat J 2018 Dec;97(12):E7-E10

University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.

Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More

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December 2018
2 Reads

[Neoendocrine carcinoma of the esophagus: report of a case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):293-296

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Departamento de Medicina Interna, Hospital Nacional Hipólito Unanue. Lima, Perú.

Neuroendocrine carcinoma of esophagus represents less than 2% of cases of cancer of the esophagus. This presentation is extremely unusual, as this type of carcinoma typically presents with greater frequency in bronchopulmonary regions. The symptoms are usually associated with esophageal obstruction and include odynophagia, dysphagia and weight loss and are not usually associated with Carcinoid syndrome. Read More

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December 2018

[Liver transplant and hepatocellular carcinoma in Peru: outcome after 15 years in the transplant department of the Guillermo Almenara Hospital - EsSalud].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):234-241

Departamento de Trasplante de órganos, Hospital Nacional Guillermo Almenara Irigoyen. Lima, Perú.

Hepatocellular carcinoma (HCC) is a neoplasm with significant incidence and prevalence in the world. In large percentage it originates from a cirrhotic liver. Liver transplantation under special conditions is effective in the simultaneous treatment of both conditions. Read More

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December 2018

Diagnostic and Prognostic Impact of Neutrophil-to-Lymphocyte Ratio for Intraductal Papillary Mucinous Neoplasms of the Pancreas With High-Grade Dysplasia and Associated Invasive Carcinoma.

Pancreas 2019 Jan;48(1):99-106

From the Departments of Surgery.

Objectives: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma.

Methods: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. Read More

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January 2019

Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.

Authors:
Kelly E McCann

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Poly-ADP-ribosyl-polymerase (PARP) inhibitors are an increasingly-utilized therapy in women with high-grade serous ovarian carcinoma, but tumor resistance to PARP inhibitor monotherapy is inevitable.

Recent Findings: PARP inhibitors have been most studied in patients with breast and ovarian cancers associated with deleterious germline BRCA1 or BRCA2 mutations, though their role has expanded to include use as maintenance therapy in women with platinum-sensitive high-grade serous ovarian cancer due to the high propensity of such cancers to have defects in DNA repair by homologous recombination. As mechanisms of PARP inhibitor resistance are elucidated, rationale combination strategies can be devised to extend therapeutic benefits and to abrogate resistance. Read More

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December 2018
1 Read

Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, First Hospital of Shanxi Medical University, Taiyua, Shanxi 030001, China.

Anaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded. Read More

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December 2018

Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study.

Endocr Relat Cancer 2019 Feb;26(2):227-239

Department of Oncology, Haukeland University Hospital, Bergen, Norway.

Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1-2 (G1-G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN G3) is largely unknown. We therefore aimed to assess the benefits and side effects of PRRT in patients with GEP NEN G3. Read More

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February 2019

New method of sentinel lymph node biopsy in transoral robotic surgery for oropharyngeal squamous cell carcinoma.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e550s. Epub 2018 Dec 10.

Cirurgia de Cabeca e Pescoco, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, BR.

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December 2018
1 Read

Squamous cell carcinoma of the tongue in patients older than 45 years.

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

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December 2018

INSULIN RESISTANCE REDUCTION AFTER SUSTAINED VIROLOGICAL RESPONSE WITH DIRECT ACTING ANTIVIRAL:NOT EVERY POPULATION IMPROVES.

Arq Gastroenterol 2018 Jul-Sep;55(3):274-278

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Clínica Médica, Botucatu, SP, Brasil.

Background: Hepatitis C virus (HCV) infection is a serious public health problem, that affects approximately 170 million people worldwide. Chronic HCV infection is associated with hepatic insulin resistance and an increased risk of diabetes HCV-infected patients has been well documented.

Objective: To assess the homeostasis model assessment of insulin resistance (HOMA-IR) index in patients treated with direct acting antiviral (DAAs) medication in the sustained virological response (SVR), categorized by the presence or absence of cirrhosis. Read More

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PATHOLOGIC COMPLETE RESPONSE (YPT0 YPN0) AFTER CHEMOTHERAPY AND RADIOTHERAPY NEOADJUVANT FOLLOWED BY ESOPHAGECTOMY IN THE SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1405. Epub 2018 Dec 6.

Digestive Diseases Surgical Unit and Gastrocenter, Department of Surgery, School of Medical Sciences, State University of Campinas - UNICAMP , Campinas, SP, Brazil.

Background: Esophageal squamous cell carcinoma is an aggressive neoplasia that requires a multidisciplinary treatment in which survival and prognosis are still not satisfactory. The complete pathologic response to neoadjuvant chemotherapy and radiotherapy is considered a good prognosis factor, and esophagectomy is indicated.

Aim: Survival analysis of cases with pathologic complete response (ypT0 ypN0) to neoadjuvant chemotherapy and/or radiotherapy, submmitted to esophagectomy. Read More

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December 2018

Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children.

Chin Med J (Engl) 2018 Dec;131(24):2938-2946

Department of Neurosurgery, Beijing Tiantan Hospital; Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.

Background: Decision-making concerning the treatment of choroid plexus tumor (CPT) in pediatric patients remains a topic of considerable debate. The aim of this work was to describe clinical features and prognostic risk factors of CPT in the pediatric population and to provide theoretical opinions regarding clinical decisions for CPT.

Methods: The data of 96 patients with CPT and younger than 14 years were retrospectively analyzed. Read More

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December 2018
1 Read

Treatment strategy for huge hepatocellular carcinoma with intrahepatic metastasis and macrovascular invasion: a case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1233-S1236

Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Macrovascular invasion, such as tumor thrombus in the major portal vein (mPVTT) or major hepatic vein (mHVTT), is regarded as indicative of an advanced stage of hepatocellular carcinoma (HCC). To date, no effective treatment has been established for this kind of HCC. We herein present a case of huge HCC with intrahepatic metastasis, mPVTT, and mHVTT. Read More

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December 2018

Gastric metastasis of recurrent hepatocellular carcinoma: A case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1230-S1232

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Hepatocellular carcinoma (HCC) with gastric metastasis is seldom reported. It is extremely easy to misdiagnose for primary gastric cancer with liver metastasis, especially gastric hepatoid adenocarcinoma. Here, we report a case of recurrent HCC with gastric metastasis in a 22-year-old man. Read More

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December 2018
1 Read

Symptomatic treatment of brain metastases in renal cell carcinoma with sorafenib.

J Cancer Res Ther 2018 Dec;14(Supplement):S1223-S1226

Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan 250012, China.

Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Read More

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December 2018
2 Reads

Cutaneous metastasis in prostate cancer: Two cases with similar clinical findings.

J Cancer Res Ther 2018 Dec;14(Supplement):S1213-S1216

Department of Pathology, Düzce University, Düzce Medical School, Düzce, Turkey.

Cutaneous metastasis of prostate cancer is rare. Lesions in this type of skin metastasis are usually seen as suprapubic nodules. Here, we presented two cases with skin metastases of prostate cancer characterized by grouped cutaneous and subcutaneous nodules. Read More

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December 2018
2 Reads

Expression of programmed death ligand-1 and programmed death 1 in hepatocellular carcinoma and its clinical significance.

J Cancer Res Ther 2018 Dec;14(Supplement):S1188-S1192

Department of Oncology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei, China.

Objective: To investigate the correlation between the expression of programmed death 1 (PD-1) and PD ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) and clinical parameters.

Materials And Methods: The study comprised tumor sections from 45 HCC patients treated with curative resection, which were evaluated for PD-1 and PD-L1 protein expression by immunohistochemistry.

Results: PD-1 and PD-L1 expression was increased in cancers compared to adjacent normal tissues, with a positive rate of 37. Read More

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December 2018

Detection of urinary trace elements and pattern recognition analysis in patients with renal cell carcinoma by inductively coupled plasma mass spectrometry.

J Cancer Res Ther 2018 Dec;14(Supplement):S1152-S1157

Department of Chemistry, Key Laboratoryof Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Objective: This study aims to observe the changes and diagnostic values of urinary trace elements in patients with renal cell carcinoma (RCC).

Methods: A total of 28 RCC patients that had been performed radical surgery for more than 3 years were included into this case-control study; meanwhile, thirty healthy volunteers without kidney diseases were set as the control group over the same period. The levels of various urinary trace elements in both groups were measured, and the results were performed the significance analysis and pattern recognition analysis using with partial least square discriminant analysis and Fisher analysis. Read More

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December 2018
1 Read

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.

J Cancer Res Ther 2018 Dec;14(Supplement):S1135-S1140

Department of General Surgery, Peking University International Hospital, Beijing 100026, China.

Background: The exact molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still unknown, and the prognosis of ESCC has not been significantly improved.

Objective: To understand the molecular mechanism of ESCC, differential modules (DMs) and key genes were identified through conducting analysis on the differential co-expression network (DCN) based on the gene expression profiles of ESCC and protein-protein interaction (PPI) data.

Materials And Methods: First, gene expression profiles of ESCC and PPI data recruiting and preprocessing were conducted; then, a DCN was constructed based on the gene co-expression and gene differential expression in ESCC; in the following, candidate DMs were mined from DCN through a systemic module searching strategy, and significance analysis was performed on candidate DMs to identify DMs; moreover, significant genes contained in the DMs were analyzed to identify the underlying biomarkers for ESCC. Read More

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December 2018

Association of cytotoxic T-lymphocyte antigen-4 + 49A/G gene polymorphism with hepatocellular carcinoma risk in Chinese.

J Cancer Res Ther 2018 Dec;14(Supplement):S1117-S1120

Department of Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Aim Of Study: Hepatocellular carcinoma (HCC), a common cause of cancer-associated mortalities worldwide, is a complex polygenic disease, and its development is dependent on many genetic factors. Hepatitis B virus infection, also called chronic hepatitis B (CHB), is the leading cause of HCC. This meta-analysis was performed to assess the association between cytotoxic T-lymphocyte antigen-4 (CTLA4) +49A/G and HCC risk. Read More

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December 2018

Association of hypoxia-inducible factor-1 alpha gene polymorphism with renal cell carcinoma susceptibility.

J Cancer Res Ther 2018 Dec;14(Supplement):S1105-S1109

Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China.

Aim Of Study: Association between hypoxia-inducible factor-1 alpha (HIF-1α) gene polymorphism and renal cell carcinoma (RCC) susceptibility is still being conflicting. This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.

Materials And Methods: Association studies were identified from the databases of PubMed and CBM-disc (China Biological Medicine Database) as of July 1, 2015, and eligible investigations were included and synthesized using meta-analysis method. Read More

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December 2018

Expression of programmed death-ligand 1 and hypoxia-inducible factor-1α proteins in endometrial carcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S1063-S1069

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Al Menoufia, Egypt.

Background: Programmed death-ligand 1 (PD-L1) and hypoxia-inducible factor-1α (HIF-1α) proteins mediate major alterations of tumor microenvironment including generation of immunosuppressive microenvironment and tumor hypoxia, respectively. These alterations play a crucial role in carcinogenesis and tumor progression.

Aims: The present study was designed to investigate the correlation between the expression of PD-L1 and HIF-1α proteins and the clinicopathologic variables in endometrial carcinoma. Read More

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December 2018

Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine.

J Cancer Res Ther 2018 Dec;14(Supplement):S1035-S1040

Department of Medical Imageology, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Aim: Norcantharidin (NCTD) has been used as a clinical antineoplastic drug in China for several years, and diamminedichloroplatinum is a valuable clinical cancer chemotherapy agent. Here, we tried to investigate the effects of NCTD plus diamminedichloroplatinum on hepatic carcinoma in murine.

Materials And Methods: In vivo and in vitro investigations on anticancer effects of the two drugs were individually made. Read More

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December 2018

Determination of core pathways for oral squamous cell carcinoma via the method of attract.

J Cancer Res Ther 2018 Dec;14(Supplement):S1029-S1034

Department of Dentistry, The Fourth Hospital of Jinan, Jinan, P.R. China.

Objective: We expected to demonstrate a practical framework for oral squamous cell carcinoma (OSCC) candidate biomarker analysis at the pathway level based on the attract method, so as to give great insights to reveal the pathological mechanism underlying this disease at its early stage.

Methods: First, gene expression profile of OSCC was recruited and preprocessed. Then, Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis was conducted. Read More

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December 2018

Appleby operation for carcinoma of the body and tail of the pancreas.

J Cancer Res Ther 2018 Dec;14(Supplement):S1019-S1023

Department of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, China.

Aims: The aim of this study is to evaluate the therapeutic efficacy of Appleby operation for carcinoma of the body and tail of pancreas.

Materials And Methods: From March 2010 to February 2015, Appleby operation was performed in 17 patients with carcinoma of the body and tail of pancreas. The values of fasting plasma blood, body weight (BW), visual analog pain intensity scale (VAS score), and the quality of life indices were evaluated before and 1 day, 1, 2, 6 weeks after surgery. Read More

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December 2018

Identification of differentiated functional modules in papillary thyroid carcinoma by analyzing differential networks.

J Cancer Res Ther 2018 Dec;14(Supplement):S969-S974

Department of Ultrasound, Linzi District People's Hospital, Zibo 255 400, Shandong Province, China.

Purpose: The incidence of papillary thyroid carcinoma (PTC) has dramatically increased over the past two decades. This study aimed to investigate the disparity of gene expression between PTC and normal tissues.

Materials And Methods: Gene chip data of E-GEOD-33630 and E-GEOD-60542 were acquired and downloaded from European Bioinformatics Institute Part of the European Molecular Biology Laboratory website. Read More

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December 2018

Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S964-S968

Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan, Guangdong 523808, China, Dongguan.

Context: The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a potential target of anticancer drug. This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC). Read More

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December 2018

miR-122 enhances sensitivity of hepatocellular carcinoma to oxaliplatin via inhibiting MDR1 by targeting Wnt/β-catenin pathway.

Authors:
Fei Cao Li-Xue Yin

Exp Mol Pathol 2018 Oct 26;106:34-43. Epub 2018 Oct 26.

School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, P.R. China; Key Laboratory of Ultrasonic Cardiac Electrophysiology and Biomechanics of Sichuan Province, Department of Cardiovascular Ultrasound and Non-invasive Cardiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, P.R. China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is one of the primary causes of cancer-related death and resistance to cytotoxic chemotherapy is the major cause of mortality in HCC patients. miR-122 is a liver specific miRNA and is found to be reduced in HCC, however, the function of miR-122 in HCC chemosensitivity remains elusive.

Methods: We used qRT-PCR to measure expressions of miR-122, β-catenin and MDR1 in four HCC cell lines. Read More

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October 2018

Immune checkpoint blockade as a potential therapeutic strategy for undifferentiated malignancies.

Hum Pathol 2018 Dec 7;82:39-45. Epub 2018 Jul 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Undifferentiated malignancies (UMs) encompass a diverse set of aggressive tumors that pose not only a diagnostic challenge but also a challenge for clinical management. Most tumors in this category are currently treated empirically with nonspecific chemotherapeutic agents that yield extremely poor clinical response. Given that UMs are inherently genetically unstable neoplasms with the potential for immune dysregulation and increased neoantigen production, they are likely to be particularly amenable to immune checkpoint inhibitors, which target programmed cell death protein 1 (PD-1) or its ligands, PD-L1 and PD-L2, to promote T-cell antitumor activity. Read More

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December 2018

Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.

Cell Mol Gastroenterol Hepatol 2018 Sep 19;7(1):211-231. Epub 2018 Sep 19.

Tianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. Electronic address:

Background & Aims: Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent nonalcoholic fatty liver disease, characterized by inflammatory cell infiltration and hepatocellular damage. Mammalian target of rapamycin complex 1 (mTORC1) has been investigated extensively in the context of cancer, including hepatocellular carcinoma. However, the role of mTORC1 in NASH remains largely unknown. Read More

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September 2018

Cystathionine β-synthase induces multidrug resistance and metastasis in hepatocellular carcinoma.

Curr Mol Med 2018 Dec 11. Epub 2018 Dec 11.

College of Pharmacy, Joint International Research Laboratory of Food & Medicine,Henan University, Kaifeng 475004, Henan Province. China.

Objective: This study aims to analyze whether Cystathionine β-synthase (CBS) plays roles in hepatocellular carcinoma (HCC) drug resistance.

Methods: MTS assay was used to detect the effect of chemotherapeutic drugs doxorubicin (DOX) and sunitinib on HCC cell viability and cell growth. Intracellular doxorubicin accumulation assay was performed to evaluate the sensitivity of DOX and sunitinib in HCC cells and the function of multidrug resistance-associated protein P-glycoprotein (P-gp). Read More

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December 2018

Biomarkers and pathways of chemoresistance and chemosensitivity for personalized treatment of pancreatic adenocarcinoma.

Pharmacogenomics 2018 Dec 12. Epub 2018 Dec 12.

Department of Oncology, Faculty of Medicine & Dentistry, Palacky University Olomouc, University Hospital Olomouc, Czech Republic.

Pancreatic carcinoma is usually diagnosed late when treatment options are limited and is considered a chemo-resistant malignancy. However, early stage, good performance status and specific patient subgroup are thought to have a more favorable prognosis. Search for novel molecular biomarkers, which could predict treatment resistance, represents a major opportunity, but also a challenge in further research. Read More

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December 2018

Exosome-like Nanozyme Vesicles for H2O2-responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma.

Nano Lett 2018 Dec 12. Epub 2018 Dec 12.

Photoacoustic imaging (PAI) is an attractive imaging modality, which is promising for clinical cancer diagnosis due to its advantages on deep tissue penetration and fine spatial resolution. However, few tumor catalytic/responsive PAI strategies are developed. Here, we design an exosome-like nanozyme vesicle for in vivo H2O2-responsive PAI of nasopharyngeal carcinoma (NPC). Read More

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December 2018

In vivo model systems for hepatitis B virus research.

ACS Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Hepatitis B virus (HBV) globally affects more than 257 million people, resulting in progressively worsening liver disease, manifesting as fibrosis, cirrhosis and hepatocellular carcinoma. The exceptionally narrow species tropism of HBV restricts its natural hosts to humans and non-human primates, including chimpanzees, gorillas, gibbons, and orangutans. The unavailability of completely immunocompetent small-animal models has contributed to the lack of curative therapeutic interventions. Read More

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December 2018

Detection of Autoantibodies by Indirect Immunofluorescence Cytochemistry on Hep-2 Cells.

Methods Mol Biol 2019 ;1901:19-46

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Indirect immunofluorescence assay (IFA) has been used for detection of autoantibodies against cellular antigens for more than 50 years. Originally using rodent tissue as substrate, the method was optimized by using the human immortal HEp-2 cell line derived from a larynx epidermal carcinoma. The HEp-2/IFA platform allows for optimal visualization of several cellular domains recognized by autoantibodies in the samples being tested. Read More

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January 2019

APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

Hepatol Int 2018 Dec 11. Epub 2018 Dec 11.

Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu-shi, Yamanashi, 400-8506, Japan.

Chronic hepatitis C virus (HCV) infection is common among patients with chronic kidney disease (CKD) and those on hemodialysis due to nosocomial infections and past blood transfusions. While a majority of HCV-infected patients with end-stage renal disease are asymptomatic, some may ultimately experience decompensated liver diseases and hepatocellular carcinoma. Administration of a combination of elbasvir/grazoprevir for 12 weeks leads to high sustained virologic response (SVR) rates in patients with HCV genotypes (GTs) 1a, 1b or 4 and stage 4 or 5 CKD. Read More

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December 2018

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Plastic Surgery, Tan Tock Seng Hospital, Singapore, Republic of Singapore.

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. Read More

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December 2018
1 Read

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Cell Oncol (Dordr) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N University Ave, Room 2029C, Ann Arbor, MI, 48109-1078, USA.

Purpose: Emerging evidence indicates that bromodomains comprise a conserved class of epigenome readers involved in cancer development and inflammation. Bromodomains are associated with epigenetic modifications of gene transcription through interactions with lysine residues of histone tails. Particularly, the bromodomain and extra-terminal domain (BET) family member BRD4 has been found to be involved in the control over oncogenes, including c-MYC, and in the maintenance of downstream inflammatory processes. Read More

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December 2018
1 Read

Significant inter- and intra-laboratory variation in grading of ductal carcinoma in situ of the breast: a nationwide study of 4901 patients in the Netherlands.

Breast Cancer Res Treat 2018 Dec 11. Epub 2018 Dec 11.

Foundation PALGA (the nationwide network and registry of histo-and cytopathology in the Netherlands), Houten, The Netherlands.

Purpose: A considerable part of ductal carcinoma in situ (DCIS) lesions may never progress into invasive breast cancer. However, standard treatment consists of surgical excision. Trials aim to identify a subgroup of low-risk DCIS patients that can safely forgo surgical treatment based on histologic grade, which highlights the importance of accurate grading. Read More

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December 2018
2 Reads

Barriers to Disease Monitoring and Liver Cancer Surveillance Among Patients with Chronic Hepatitis B in the United States.

J Community Health 2018 Dec 11. Epub 2018 Dec 11.

Asian Liver Center, Department of Surgery, Stanford University School of Medicine, 780 Welch Road, CJ 130, Palo Alto, CA, 94304-5787, USA.

Chronic hepatitis B infection (CHB) is a condition that needs ongoing care such as monitoring for liver enzymes (ALT) and HBV DNA tests in treated and untreated patients, and annual imaging evaluation for liver cancer. Although follow-up care and treatment might seem straight forward, an estimated two-thirds of those who are aware of their infection are not seeing a health care provider, and more than half of those who are eligible for treatment do not receive it. This study aimed to compile and examine studies related to the barriers of disease monitoring, treatment, and liver cancer surveillance for CHB patients in the United States (US). Read More

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December 2018

Reproductive and menopausal factors and risk of second primary breast cancer after in situ breast carcinoma.

Cancer Causes Control 2018 Dec 11. Epub 2018 Dec 11.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-C308, Seattle, WA, 98109, USA.

Purpose: In situ breast cancer patients have a higher risk of developing a second primary breast cancer than women in the general population have of developing breast cancer. We have limited understanding of why some women with a previous in situ breast cancer develop second primary breast cancers while others do not.

Methods: In this population-based nested case-control study, we evaluated the association between reproductive and menopausal factors and risk of developing a second primary breast cancer among women with a previous in situ breast cancer. Read More

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December 2018

Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.

Objective: To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML).

Subjects And Methods: Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Read More

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December 2018

Transoral Robotic Thyroidectomy for Papillary Thyroid Carcinoma: Perioperative Outcomes of 100 Consecutive Patients.

World J Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). Read More

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December 2018
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Association of advanced hepatic fibrosis and sonographic visualization score: a dual-center study using ACR US LI-RADS.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.

Purpose: To evaluate the association between imaging and clinical features and visualization scores, as specified by American College of Radiology (ACR) Ultrasound Liver Imaging Reporting and Data System (LI-RADS), on hepatocellular carcinoma (HCC) screening ultrasound examinations.

Methods: In this dual-center retrospective study, HCC screening ultrasound reports containing ultrasound elastography measurements (January to September, 2017) were reviewed. Ultrasound point shear wave elastography and 2-dimensional shear wave elastography were used to assess liver stiffness; median shear wave velocity was translated to METAVIR fibrosis scoring, per previously published data. Read More

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December 2018

Correction to: Reason of Discontinuation After Transarterial Chemoembolization Influences Survival in Patients with Hepatocellular Carcinoma.

Cardiovasc Intervent Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Toward the end of the second paragraph in the Discussion section, there is a word missing in the sentence. Read More

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December 2018
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