442 results match your criteria Carcinoma Ex Pleomorphic Adenoma


Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
1 Read

Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report.

World J Clin Cases 2019 Mar;7(6):792-797

Department of Head & Neck Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.

Case Summary: This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448082PMC
March 2019
1 Read

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with limited treatment options and poor outcome. Twenty-nine primary resected SDC, including 15 SDC de novo (SDCDN), and 14 SDC ex pleomorphic adenoma (SDCXPA) were subjected to the massive parallel sequencing assay (MSK-IMPACT™) targeting 287-468 cancer-related genes. TP53 was the most frequently altered gene (69%). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.004DOI Listing
April 2019
3 Reads

Ossified Carcinoma Ex Pleomorphic Adenoma in accessory lobe of parotid gland: Complexity in clinical, imaging and histologic diagnosis and minimally invasive surgery.

Oral Oncol 2019 Mar 7. Epub 2019 Mar 7.

Maxillofacial Surgery Unit, Department of Maxillo-Facial Surgery, University of Naples "Federico II", Naples, Italy. Electronic address:

Carcinoma ex pleomorphic adenoma is not common among malignant salivary tumors and an accessory lobe of parotid gland tumor with a carcinoma ex pleomorphic adenoma histology is even rarer. Management of these tumors include a high index of suspicion, good understanding of the anatomy and a meticulous surgical access. The exceptional localization of an ossified Carcinoma ex Pleomorphic Adenoma in the accessory lobe of the parotid gland, never reported to date in the literature, has prompted us to report this case to stress the challenging difficulties related to clinical and histologic diagnosis and to analyze a minimally invasive intraoral approach. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.003DOI Listing
March 2019
1 Read

Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas.

Oral Oncol 2019 Mar 1;90:30-37. Epub 2019 Feb 1.

Department of Head and Neck Surgery, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan. Electronic address:

Objectives: The aim of the present study was to investigate the molecular basis for the use of immune checkpoint inhibitors to treat salivary gland carcinomas (SGC).

Materials And Methods: We examined the clinical and prognostic significance of programed death ligands 1 and 2 (PD-L1 and -L2) expression using immunohistochemistry and in situ hybridization, as well as microsatellite instability (MSI) status using polymerase chain reaction, along with tumor-infiltrating lymphocytes (TILs) in 30 cases of SGC.

Results: The SGC cases studied included adenoid cystic carcinoma (AdCC, 36. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.015DOI Listing
March 2019
2 Reads

Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Am J Surg Pathol 2019 May;43(5):601-609

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001218DOI Listing
May 2019
1 Read

Extracapsular invasion: A potential prognostic marker for Carcinoma ex-pleomorphic adenoma of the salivary glands? A Systematic Review.

J Oral Pathol Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Background: The aim of the present study was to integrate available data published in the literature on extracapsular invasion in cases of CXPA that correlated findings with the prognosis of analysed patients.

Methods: An electronic search was carried out at the MEDLINE/PubMed, EMBASE and Cochrane Collaboration Library databases. Articles that assessed the relationship between extracapsular invasion and survival of patients diagnosed with CXPA were selected for the systematic review. Read More

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http://dx.doi.org/10.1111/jop.12841DOI Listing
February 2019
1 Read

Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma.

Case Rep Oncol 2018 Sep-Dec;11(3):835-841. Epub 2018 Dec 11.

Department of Medical Oncology, Sapporo Medical University, Sapporo, Japan.

Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. Read More

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http://dx.doi.org/10.1159/000495344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341428PMC
December 2018
10 Reads

Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology.

Head Neck Pathol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, National University Hospital, Singapore, Singapore.

We present a case of a primary 2.5 cm pleomorphic lipoma of the right parotid gland with prominent myxoid change which on FNA displayed features that mimicked a carcinoma or sarcoma ex pleomorphic adenoma. The patient was a 79 year old man with no oncological history or tumor elsewhere. Read More

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http://link.springer.com/10.1007/s12105-018-00998-9
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http://dx.doi.org/10.1007/s12105-018-00998-9DOI Listing
January 2019
4 Reads

Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.

J Oral Pathol Med 2019 Mar 16;48(3):232-238. Epub 2019 Jan 16.

Department of Oral Diagnosis, Oral Pathology, Piracicaba Dental School, State University of Campinas (FOP-UNICAMP), Piracicaba, Brazil.

Background: Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors.

Methods: We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs).

Results: Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0. Read More

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http://doi.wiley.com/10.1111/jop.12820
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http://dx.doi.org/10.1111/jop.12820DOI Listing
March 2019
9 Reads

Human epithelial growth factor receptor 2 in human salivary carcinoma ex pleomorphic adenoma: a potential therapeutic target.

Cancer Manag Res 2018 30;10:6571-6579. Epub 2018 Nov 30.

Department of Oral Pathology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, People's Republic of China,

Background: To inhibit human epithelial growth factor receptor 2 (HER2) in salivary carcinoma ex pleomorphic adenoma (CXPA) and investigate the effects on tumor cell proliferation, cell cycle, and apoptosis. To assess the possibility of blocking HER2 to improve the malignant biological behavior of CXPA.

Materials And Methods: HER2 expression and amplification were examined using an immunofluorescence assay and fluorescence in situ hybridization in 2 CXPA cell lines (SM-AP1 and SM-AP4 cells). Read More

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http://dx.doi.org/10.2147/CMAR.S182652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280888PMC
November 2018
5 Reads

Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis.

Head Neck Pathol 2018 Nov 27. Epub 2018 Nov 27.

Pathology Division, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor of the salivary gland that arises from pleomorphic adenoma (PA). Squamous cell carcinoma (SCC) is extremely rare in the salivary glands. We report two cases of acantholytic SCC (ASCC) ex PA. Read More

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http://dx.doi.org/10.1007/s12105-018-0987-2DOI Listing
November 2018
3 Reads

Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma.

Head Neck Pathol 2018 Nov 2. Epub 2018 Nov 2.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Salivary duct carcinoma (SDC) is an aggressive neoplasm that resembles high-grade invasive ductal carcinoma of the breast. It can develop de novo or from the malignant transformation of pleomorphic adenoma (PA). We performed immunohistochemical stains for phosphatase and tensin homologue [PTEN androgen receptor (AR)], HER2/neu, cytokeratin 5/6, estrogen receptor-beta, high-mobility group AT-hook 2 (HMGA2), and pleomorphic adenoma gene 1 (PLAG1) on tissue microarray samples of 75 SDCs and 31 adenocarcinomas, not otherwise specified (NOS). Read More

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http://link.springer.com/10.1007/s12105-018-0984-5
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http://dx.doi.org/10.1007/s12105-018-0984-5DOI Listing
November 2018
22 Reads

Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features.

Histopathology 2019 Feb 2;74(3):514-525. Epub 2018 Dec 2.

Department of Human Pathology, School of Medicine, Juntendo University, Tokyo, Japan.

Aims: Pleomorphic adenoma gene 1 (PLAG1) rearrangement is well known in pleomorphic adenoma (PA), which is histologically characterised by admixed epithelial and mesenchymal components. Multiple fusion variants of PLAG1 and HMGA2 have been reported; currently, however, little is known regarding the clinicopathological impacts of these fusion types METHODS AND RESULTS: We examined the PLAG1- and HMGA2-related fusion status in 105 PAs and 11 cases of carcinoma ex PAs (CXPA) arising from salivary glands and lacrimal glands to elucidate their correlation to the clinicopathological factors. Forty cases harboured PLAG1 fusion genes: CTNNB1-PLAG1 in 22 cases, CHCHD7-PLAG1 in 14 cases and LIFR-PLAG1 in four cases. Read More

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http://dx.doi.org/10.1111/his.13759DOI Listing
February 2019
4 Reads

CD44 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma and their adjacent normal salivary glands.

Dent Res J (Isfahan) 2018 Sep-Oct;15(5):361-366

Department of Endodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: CD44 is a transmembranous proteoglycan, with a main role of cell adhesion to other cells and to extracellular matrix involved in the preservation of three-dimensional structure of organs. Pleomorphic adenoma (PA) is a common benign salivary gland tumor, composed of myoepithelial and ductal components. Carcinoma ex-PA (CXPA) is malignant transformation of the epithelial elements in PA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134731PMC
September 2018
4 Reads

Surgical treatment results of parapharyngeal space tumors: a report of 22 cases.

Otolaryngol Pol 2018 May;72(4):9-16

Medical University of Warsaw Otolaryngology Depatment.

Introduction: Parapharyngeal space (PPS) is the anatomical area lateral to the upper pharynx and clinically important due to PPS tumors. They account for less than 1% of head and neck neoplasms. Both benign and malignant neoplasms may arise there and typical for this localization is diversity of histological origin. Read More

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http://dx.doi.org/10.5604/01.3001.0012.0485DOI Listing
May 2018
21 Reads

Lacrimal gland tumors in Turkey: types, frequency, and outcomes.

Int J Ophthalmol 2018 18;11(8):1296-1302. Epub 2018 Aug 18.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Aim: To evaluate the clinical, radiological, and treatment features of lacrimal gland tumors.

Methods: Retrospective review of 99 eyes of 92 patients with lacrimal gland tumors diagnosed and managed in a single institution between January 1999 and March 2017. Clinical and radiological features, histopathology, treatment methods, and prognosis were evaluated. Read More

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http://dx.doi.org/10.18240/ijo.2018.08.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090115PMC
August 2018
5 Reads

Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):77-84

Medical Oncology Service, St Bartholomew's Hospital, London, United Kingdom.

Purpose: To ascertain long-term outcome of treatment for primary epithelial malignancies of the lacrimal gland and compare outcomes after cranio-orbital resection or after macroscopic tumor resection with radiotherapy.

Methods: Comparative case series of 79 patients (49 male; 62%) treated for primary epithelial malignancies of the lacrimal gland at Moorfields Eye Hospital between 1972 and 2014. Patients were identified from clinical and pathological databases and, where available, the clinical, pathological, and imaging records reviewed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001177DOI Listing
August 2018
14 Reads

Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma.

Oral Oncol 2018 Sep 30;84:106-107. Epub 2018 Jul 30.

Departmento de Anatomia Patológica, Universidade Estadual de Campinas, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.07.003DOI Listing
September 2018
8 Reads

Trastuzumab Emtansine for the Treatment of HER-2 Positive Carcinoma Ex-pleomorphic Adenoma Metastatic to the Brain: A Case Report.

Front Oncol 2018 24;8:274. Epub 2018 Jul 24.

Department of Radiation Oncology, American University of Beirut, Beirut, Lebanon.

Carcinoma Ex-pleomorphic adenoma is a malignant transformation of the common benign neoplasm of the salivary glands, "pleomorphic adenoma." Only two cases were ever reported with brain metastases, with absence of good evidence guiding management of such cases. A 61-year-old woman presenting with facial paralysis was found to have carcinoma ex-pleomorphic adenoma of the parotid gland. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00274/
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http://dx.doi.org/10.3389/fonc.2018.00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066556PMC
July 2018
6 Reads

Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges.

Oman Med J 2018 Jul;33(4):342-345

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia.

Parotid gland surgery can be challenging due to intricate relationship between the gland and facial nerve. Besides complete removal of the lesion, the main focus of surgery is centered on the facial nerve. Surgery can be technically demanding especially when the tumor is large or involves the deep lobe. Read More

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http://dx.doi.org/10.5001/omj.2018.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047185PMC
July 2018
3 Reads

Primary carcinoma ex-pleomorphic adenoma of anterior commissure of the larynx.

Oral Oncol 2018 Sep 4;84:131-133. Epub 2018 Jul 4.

Department of Clinical Oncology, Northern Centre for Cancer Care, The Newcastle upon Tyne NHS Hospitals Foundation Trust, Newcastle upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.06.027DOI Listing
September 2018

Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid.

J Cancer Res Ther 2018 Apr-Jun;14(3):706-708

Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. RML Hospital, New Delhi, India.

Carcinoma ex pleomorphic adenoma (Ca ex PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma. The most common histological subtype is adenocarcinoma, not otherwise specified, salivary duct carcinoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma (ACC). Few case reports of de novo dedifferentiation in ACC are there in the literature, mostly involving minor salivary glands. Read More

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http://dx.doi.org/10.4103/0973-1482.179522DOI Listing
November 2018
24 Reads

Metastasizing pleomorphic adenoma in the multiple organs: A case report on FDG-PET/CT imaging.

Medicine (Baltimore) 2018 Jun;97(23):e11077

Department of Pathology, The Cancer Institute Hospital of JFCR, Tokyo, Japan.

Rationale: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. Read More

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http://dx.doi.org/10.1097/MD.0000000000011077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999481PMC
June 2018
9 Reads

[Pharyngeal space carcinoma ex pleomorphic adenoma:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;32(9):710-712

Carcinoma ex pleomorphic adenoma is an epithelial malignant tumor of pleomorphic adenoma. This may be due to the accumulation of genetic instability caused by long-term pleomorphic adenomas. There are few reports of parapharyngeal space carcinoma ex pleomorphic adenoma in the literature study both at home and abroad. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.09.017DOI Listing
May 2018
6 Reads

Pleomorphic adenoma of the lacrimal gland: A review with updates on malignant transformation and molecular genetics.

Saudi J Ophthalmol 2018 Jan-Mar;32(1):13-16. Epub 2018 Mar 2.

Duke University Medical Center, Department of Pathology, United States.

Pleomorphic adenoma (benign mixed tumor) is the most common epithelial neoplasm of the lacrimal gland. It is usually a slow growing, well-circumscribed, mass that is identical to its salivary gland counterpart. Patients generally have an excellent prognosis for vision and long-term survival after complete surgical excision. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13194534183006
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http://dx.doi.org/10.1016/j.sjopt.2018.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943819PMC
March 2018
10 Reads

Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers.

Head Neck Pathol 2018 Apr 18. Epub 2018 Apr 18.

Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, 19 Claremont Crescent, Sheffield, S10 2TA, UK.

DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Read More

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http://dx.doi.org/10.1007/s12105-018-0917-3DOI Listing
April 2018
8 Reads

Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland.

Eur Arch Otorhinolaryngol 2018 Jun 29;275(6):1595-1600. Epub 2018 Mar 29.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Av. Sen Salgado Filho, 1787, Lagoa Nova, Natal, RN, 59056-000, Brazil.

Introduction: Cripto-1 is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family. Besides being critical for early embryonic development, Cripto-1 is also associated with the development and behavior of several cancers.

Objective: We analyzed the immunoexpression of Cripto-1 in normal salivary glands (NSGs), pleomorphic adenomas (PAs), and carcinoma ex pleomorphic adenomas (CaExPAs) of salivary glands. Read More

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http://dx.doi.org/10.1007/s00405-018-4960-1DOI Listing
June 2018
16 Reads

Carcinosarcoma ex Pleomorphic Adenoma of the Submandibular Gland in a 64-Year-Old Man: A Case Report.

J Nippon Med Sch 2018 ;85(1):51-55

Department of Diagnostic Pathology, Nippon Medical School Hospital.

Carcinosarcoma (CS) is a rare tumor, consisting of both carcinomatous and sarcomatous components. In this paper, we present a case of CS arising from a pleomorphic adenoma (PA) of the submandibular gland. A 64-year-old Japanese man presented with a left submandibular mass that had developed for 20 years with complaints of pain for the last 3 months. Read More

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http://dx.doi.org/10.1272/jnms.2018_85-8DOI Listing
August 2018
6 Reads

RANK and RANK Ligand Expression in Parotid Gland Carcinomas.

Appl Immunohistochem Mol Morphol 2018 08;26(7):478-482

Section of Otolaryngology, Head and Neck Surgery, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic parameters. Formalin-fixed paraffin-embedded tumor samples from 46 consecutive cases of parotid gland carcinoma were selected for this study. Read More

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http://Insights.ovid.com/crossref?an=00129039-201808000-0000
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http://dx.doi.org/10.1097/PAI.0000000000000465DOI Listing
August 2018
6 Reads

Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

Acta Ophthalmol 2018 Nov 13;96(7):e768-e771. Epub 2018 Feb 13.

Department of Ophthalmology, Rigshospitalet-Glostrup, Glostrup, Denmark.

Purpose: Lacrimal gland tumours constitute a wide spectrum of neoplastic lesions that are histologically similar to tumours of the salivary gland. In the salivary gland, pleomorphic adenoma (PA) is frequently characterized by recurrent chromosomal rearrangements of the PLAG1 and HMGA2 genes, a genetic feature retained in carcinoma ex pleomorphic adenoma (ca-ex-PA) that makes it possible to distinguish ca-ex-PA from de novo carcinomas. However, whether PLAG1 and HMGA2 gene rearrangements are found in lacrimal gland PA and ca-ex-PA is not known. Read More

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http://dx.doi.org/10.1111/aos.13667DOI Listing
November 2018
11 Reads
2.844 Impact Factor

Tumors of the parapharyngeal space: the VU University Medical Center experience over a 20-year period.

Eur Arch Otorhinolaryngol 2018 Apr 7;275(4):967-972. Epub 2018 Feb 7.

Department of Otolaryngology and Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Background: Tumors of the parapharyngeal space (PPS) are rare, accounting for 0.5-1.5% of all head and neck tumors. Read More

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http://dx.doi.org/10.1007/s00405-018-4891-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838131PMC
April 2018
6 Reads

Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas.

Oncotarget 2018 Jan 4;9(2):1852-1867. Epub 2017 Dec 4.

Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.

The molecular characteristics of therapeutically-relevant targets and their clinicopathological implications in salivary duct carcinomas (SDCs) are poorly understood. We investigated the gene alterations and the immunoexpression of crucial oncogenic molecules in 151 SDCs. The mutation rates that were identified, in order of frequency, were as follows: , 68%; , 18%; , 16%; , 4%; and , 1. Read More

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http://dx.doi.org/10.18632/oncotarget.22927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788604PMC
January 2018
10 Reads

Lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma: A clinicopathological report and review of the literature.

Mol Clin Oncol 2018 Jan 3;8(1):209-213. Epub 2017 Nov 3.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Bangkok 10400, Thailand.

Myoepithelial carcinoma is an uncommon malignant tumor of the lacrimal gland, composed of neoplastic myoepithelial cells with an infiltrative growth. The present study describes a unique case of progressive proptosis and blindness of the right eye in a 68-year-old woman following total tumor removal for lacrimal pleomorphic adenoma. Clinical study, surgical exploration, and pathology revealed lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma, T2N0M0. Read More

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http://www.spandidos-publications.com/10.3892/mco.2017.1488
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http://dx.doi.org/10.3892/mco.2017.1488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769277PMC
January 2018
11 Reads

Gray scale and doppler ultrasonography features of the carcinoma ex pleomorphic adenoma.

Dentomaxillofac Radiol 2018 May 13;47(4):20170268. Epub 2018 Feb 13.

2 Department of Pathology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao tong University , Shanghai , PR China.

Objectives: For lesions in the salivary glands, ultrasonography (US) is an ideal tool for initial assessment. The aim of this study was to characterize and differentiate between the Gray scale and Doppler US findings of intracapsular carcinoma ex pleomorphic adenoma (Ic-CxPA) and invasive carcinoma ex pleomorphic adenoma (Inv-CxPA).

Methods: A total of 87 patients (89 lesions) with histopathologically proven CxPA underwent US examination. Read More

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http://dx.doi.org/10.1259/dmfr.20170268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991755PMC
May 2018
14 Reads

BRCA1/2 Mutations in Salivary Pleomorphic Adenoma and Carcinoma-ex-Pleomorphic Adenoma.

J Int Soc Prev Community Dent 2017 Nov 30;7(Suppl 3):S155-S162. Epub 2017 Nov 30.

Department of Pathology, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: It is hypothesized that carcinoma-ex-pleomorphic adenoma (Ca-ex-PA) is malignant from the beginning or is a malignant transformation of a recurrent or a long-standing pleomorphic adenoma (PA). The accumulation of genetic instabilities is suggested to be the main reason for malignant transformation in PA. The aim of this study was to determine the prevalence of BRCA1/2 mutations in PA and Ca-ex-PA. Read More

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http://dx.doi.org/10.4103/jispcd.JISPCD_184_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730978PMC
November 2017
12 Reads

Expression of Topoisomerase II-α protein in salivary gland tumors.

Mol Clin Oncol 2017 Dec 20;7(6):1064-1068. Epub 2017 Oct 20.

Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel.

Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma and carcinoma ex-pleomorphic adenoma. A total of 59 cases of benign and malignant salivary gland tumors were included in the present study. Read More

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http://dx.doi.org/10.3892/mco.2017.1463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740864PMC
December 2017
10 Reads

Promoter hypermethylation may contribute to E‑cadherin repression in the human salivary carcinoma ex pleomorphic adenoma.

Int J Oncol 2018 Feb 22;52(2):496-504. Epub 2017 Nov 22.

Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.

The role of promoter methylation in the inactivation of E‑cadherin (CDH1) in salivary carcinoma ex pleomorphic adenoma (CXPA) is unknown. The objective of this study was to determine the role and potential clinical implications of CDH1 promoter methylation in salivary CXPA. The CDH1 promoter methylation status was determined by bisulfite sequencing PCR in 37 primary CXPA tissues and 2 CXPA cell lines. Read More

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http://dx.doi.org/10.3892/ijo.2017.4210DOI Listing
February 2018
10 Reads

Intracapsular carcinoma ex-pleomorphic adenoma of the parapharyngeal space: report of two cases and review of the literature.

Tumori 2017 Nov 15;103(Suppl. 1):e73-e77. Epub 2017 Nov 15.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia - Italy.

Background: Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity.

Methods: The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed.

Results: Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases. Read More

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http://dx.doi.org/10.5301/tj.5000688DOI Listing
November 2017
16 Reads

Epithelial-Myoepithelial Carcinoma: Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases.

Am J Surg Pathol 2018 Jan;42(1):18-27

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

We hypothesized that there is a relationship between the preexisting pleomorphic adenoma [PA]), histologic grade of epithelial-myoepithelial carcinomas (EMCAs), and genetic alterations. EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS). Twenty-three EMCAs were further analyzed by NGS for mutations and copy number variation in 50 cancer-related genes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000933DOI Listing
January 2018
29 Reads

Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies.

Ann Oncol 2017 Oct;28(10):2539-2546

Division of Medical Oncology, University of Colorado School of Medicine, Aurora, USA.

Background: Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of histologic subtypes associated with variable clinical aggressiveness and response to local and systemic therapies. We queried whether comprehensive genomic profiling could define the tumor subtypes and uncover clinically relevant genomic alterations, revealing new routes to targeted therapies for patients with relapsed and metastatic disease.

Patients And Methods: From a series of 85 686 clinical cases, DNA was extracted from 40 µm of formalin-fixed paraffin embedded (FFPE) sections for 623 consecutive SGC. Read More

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http://dx.doi.org/10.1093/annonc/mdx399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834110PMC
October 2017
11 Reads

Prognostic nomogram for disease-specific survival of carcinoma ex pleomorphic adenoma of the salivary gland.

Head Neck 2017 12 25;39(12):2416-2424. Epub 2017 Sep 25.

Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, People's Republic of China.

Background: The purpose of this study was to establish an effective prognostic nomogram for carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary gland.

Methods: The nomogram was based on a retrospective study on 223 patients who underwent surgical operation for Ca-ex-PA from 2001 to 2010. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve. Read More

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http://dx.doi.org/10.1002/hed.24908DOI Listing
December 2017
15 Reads

Biomarker immunoprofile in salivary duct carcinomas: clinicopathological and prognostic implications with evaluation of the revised classification.

Oncotarget 2017 Aug 2;8(35):59023-59035. Epub 2017 Aug 2.

Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.

Salivary duct carcinoma (SDC) is an uncommon, aggressive malignant neoplasm histologically resembling high-grade mammary ductal carcinoma. SDC can arise or ex pleomorphic adenoma. To clarify the correlation of biomarker immunoprofile with clinicopathological findings and clinical outcome of SDC, we conducted immunohistochemistry for EGFR, HER2, HER3, AR, CK5/6, p53, and Ki-67, along with HER2 fluorescence hybridization in 151 SDCs. Read More

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http://dx.doi.org/10.18632/oncotarget.19812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601711PMC
August 2017
21 Reads

Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity.

Pathobiology 2018 21;85(1-2):85-95. Epub 2017 Sep 21.

Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon, Portugal.

Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e. Read More

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http://dx.doi.org/10.1159/000479070DOI Listing
October 2018
16 Reads

Effect of epithelial growth factor on matrix metalloproteinase-2 and E-cadherin/β-catenin expression in an model of tumorigenesis.

Oncol Lett 2017 Sep 30;14(3):3136-3140. Epub 2017 Jun 30.

Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo 13045-755, Brazil.

The aim of the present study was to analyze the effect of various doses of epidermal growth factor (EGF; 5 and 10 ng/ml) on matrix metalloproteinase-2 (MMP-2) secretion and E-cadherin/β-catenin expression by co-cultured cells that mimic an carcinoma ex-pleomorphic adenoma, where benign myoepithelial cells from a pleomorphic adenoma surround malignant epithelial cells. EGF was supplemented in various doses and the effects were evaluated following four days of cell culture. ELISA was performed to determine MMP-2 secretion levels. Read More

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http://dx.doi.org/10.3892/ol.2017.6513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588072PMC
September 2017
12 Reads

Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome.

Virchows Arch 2017 Dec 25;471(6):775-784. Epub 2017 Aug 25.

Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, São Paulo, São Paulo, 222705208-000, Brazil.

SOX2 is a regulatory factor of embryonic stem cells that has been implicated in carcinogenesis and cancer progression. We aimed to investigate the potential role of SOX2 in the stepwise progression from pleomorphic adenoma (PA) to invasive carcinoma ex pleomorphic adenoma (CXPA), evaluating its prognostic significance as well. Thirty PAs without malignant transformation and 25 CXPAs presenting both luminal or myoepithelial differentiation (7 intracapsular and 18 extracapsular) were evaluated immunohistochemically for SOX2 expression. Read More

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http://dx.doi.org/10.1007/s00428-017-2220-1DOI Listing
December 2017
14 Reads

Impact of postoperative radiotherapy and HER2/new overexpression in salivary duct carcinoma : A monocentric clinicopathologic analysis.

Strahlenther Onkol 2017 Nov 21;193(11):961-970. Epub 2017 Aug 21.

Institute of Pathology, University Hospital of Erlangen, Erlangen, Germany.

Aim: Retrospective Investigation of the prognostic relevance of clinicopathologic parameters in patients with salivary duct carcinoma (SDC).

Methods: An experienced pathologist reviewed 67 patients with de novo SDC or SDC ex pleomorphic adenoma. Paraffin-embedded tumor samples were examined by immunohistochemistry for expression of HER2/neu, androgen (AR), progesterone (PR), estrogen (ER), epidermal growth factor (EGFR) and programmed death ligand 1 (PD-L1-R) receptor. Read More

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http://dx.doi.org/10.1007/s00066-017-1196-8DOI Listing
November 2017
11 Reads

PLAG1 immunohistochemistry is a sensitive marker for pleomorphic adenoma: a comparative study with PLAG1 genetic abnormalities.

Histopathology 2018 Jan 19;72(2):285-293. Epub 2017 Oct 19.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Aims: Pleomorphic adenoma gene 1 (PLAG1) gene rearrangement is the most common genetic abnormality in pleomorphic adenoma (PA), resulting in overexpression of PLAG1 protein. PA and carcinoma ex pleomorphic adenoma (CA ex-PA) can mimic various benign and malignant salivary gland tumours. The aims of this study are to evaluate the sensitivity and specificity of PLAG1 immunohistochemistry (IHC) in the differential diagnosis of PA and CA ex-PA and to compare the PLAG1 immunohistochemical results to PLAG1 gene abnormalities as detected by fluorescence in-situ hybridisation (FISH). Read More

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http://doi.wiley.com/10.1111/his.13341
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http://dx.doi.org/10.1111/his.13341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730461PMC
January 2018
18 Reads

Expression of Hormone Receptors and HER-2 in Benign and Malignant Salivary Gland Tumors.

Head Neck Pathol 2018 Mar 5;12(1):95-104. Epub 2017 Jul 5.

Department of Pathology, The University of Chicago Medicine, 5841 S. Maryland Ave, MC 6101, Chicago, IL, 60637, USA.

With the advent of targeted therapies, expression of sex hormone receptors and HER-2 in salivary gland tumors (SGTs) is of clinical interest. Previous reports of estrogen (ER) and progesterone (PR) receptor expression have varied. Androgen receptor (AR) and HER-2 overexpression are frequently reported in salivary duct carcinoma (SDC), but have not been studied systematically in other SGTs. Read More

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http://dx.doi.org/10.1007/s12105-017-0833-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873488PMC
March 2018
25 Reads

Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy.

Curr Oncol 2017 Jun 27;24(3):e251-e254. Epub 2017 Jun 27.

Department of Medical Oncology, BC Cancer Agency.

The most common benign salivary tumour is a pleomorphic adenoma. Transformation to malignancy, carcinoma ex pleomorphic adenoma (cxpa), occurs in 6% of cases. Management focuses on surgical resection and radiotherapy; however, rare cases require systemic management. Read More

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http://dx.doi.org/10.3747/co.24.3588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486399PMC
June 2017
11 Reads