473 results match your criteria Carcinoma Ex Pleomorphic Adenoma


Signet Ring Cell Differentiation in Salivary Duct Carcinoma with Rhabdoid Features: Report of Three Cases and Literature Review.

Head Neck Pathol 2020 Jun 2. Epub 2020 Jun 2.

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Salivary duct carcinoma with rhabdoid features (SDCRF) is a rare salivary tumor with poor prognosis and is proposed as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). Here, we report three cases of SDC with rhabdoid features (SDCRF) mimicking PLCB. Pleomorphic adenoma (PA) component was accompanied in all the cases confirming carcinoma ex PA. Read More

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http://dx.doi.org/10.1007/s12105-020-01186-4DOI Listing

Microvesicles derived from squamous cell carcinoma induce cell death, autophagy, and invasion of benign myoepithelial cells.

J Oral Pathol Med 2020 May 26. Epub 2020 May 26.

Cell Biology and Oral Pathology Division, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.

Background: There has been great interest recently in the mechanisms of cell-to-cell communication through microvesicles (MV). These structures are produced by many different cell types and can modulate cellular activity by induction of epigenetic alterations. These vesicles may promote tumor mass increase either by stimulating cell proliferation via growth factors or by inhibiting apoptosis, which reinforces the role of such vesicles as important modulators of tumor progression. Read More

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http://dx.doi.org/10.1111/jop.13037DOI Listing

Prominent oncocytic metaplasia in pleomorphic adenoma: A potential diagnostic pitfall.

Diagn Cytopathol 2020 Apr 25. Epub 2020 Apr 25.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Pleomorphic adenoma (PA) is the most common salivary gland tumor. The cytological features of PA are well recognized, and its diagnosis is straightforward in most cases. Some metaplastic changes in PA are well known; however, occurrence of oncocytic metaplasia in PA is very rare. Read More

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http://dx.doi.org/10.1002/dc.24443DOI Listing

Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2020 Apr 8. Epub 2020 Apr 8.

Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery.

Purpose: To review the clinical presentation, treatment, and prognosis of patients with malignant mixed tumor (carcinoma ex pleomorphic adenoma) of the lacrimal gland.

Methods: Clinical records and radiographic images were reviewed for patients with malignant mixed tumor of the lacrimal gland treated at the center during 2008-2019.

Results: The study included 9 patients (6 men, 3 women) aged 17-66 years (median age, 56 years). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001625DOI Listing

Prognostic Impact of PD-L1 Expression in Malignant Salivary Gland Tumors as Assessed by Established Scoring Criteria: Tumor Proportion Score (TPS), Combined Positivity Score (CPS), and Immune Cell (IC) Infiltrate.

Cancers (Basel) 2020 Apr 3;12(4). Epub 2020 Apr 3.

Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany.

Background: Malignant neoplasms of the salivary glands are rare, and therapeutic options are limited. Results from recently published studies indicate a possible use for checkpoint inhibition in a subset of patients, but there are no established criteria for programme cell death ligand 1 (PD-L1) scoring in salivary gland carcinomas (SGCs).

Methods: In this retrospective study, we present a cohort of 94 SGC patients with full clinical follow-up. Read More

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http://dx.doi.org/10.3390/cancers12040873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226358PMC

Gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, and adipophilin in carcinoma ex pleomorphic adenoma development.

Oral Dis 2020 Mar 16. Epub 2020 Mar 16.

Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas, Brazil.

Objective: To analyze the gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, and adipophilin in normal salivary gland (NSG), pleomorphic adenoma (PA), and carcinoma ex pleomorphic adenoma (CXPA) samples.

Material And Methods: The gene expression was investigated by the real-time PCR (qRT-PCR) method in 9 samples of frozen tissues of normal salivary gland, 13 PA, and 10 CXPA. We validated the reactions by immunohistochemistry on 20 samples from NSG, 85 PA, and 44 CXPA. Read More

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http://dx.doi.org/10.1111/odi.13332DOI Listing

A Rare De Novo Myoepithelial Carcinoma Ex Pleomorphic Adenoma in a Young Woman.

Case Rep Otolaryngol 2020 26;2020:8325374. Epub 2020 Feb 26.

Division of Otolaryngology/Head & Neck Surgery, Howard University College of Medicine, Washington, DC, USA.

Carcinoma ex pleomorphic adenoma, an uncommon neoplasm of the parotid gland, accounts for less than 4% of salivary gland tumors. It arises from a benign pleomorphic adenoma presenting in the sixth to eighth decades of life. We present this as a unique account of a primary parotid gland carcinoma, arising from myoepithelial cells, without a known precursor lesion, in a 28-year-old woman. Read More

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http://dx.doi.org/10.1155/2020/8325374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061126PMC
February 2020

Carcinoma ex pleomorphic adenoma: a case report and review of literature.

Afr Health Sci 2019 Dec;19(4):3253-3263

Department of Restorative Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia, Pincode- 61471.

Background: Carcinoma ex pleomorphic adenoma (CA-ex-PA) is extremely unusual in minor salivary glands of oral cavity. CAex-PA is a carcinomatous change as a primary or as a recurrence of pleomorphic adenoma.

Objective: Due to resemblance of clinical symptoms of Ca ex PA and benign pleomorphic adenoma, it is mandatory for surgeons to keep high degree of clinical alertness, considering the peculiarity of this tumor. Read More

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http://dx.doi.org/10.4314/ahs.v19i4.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040348PMC
December 2019

Ductal Adenocarcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland: a Rare and Morbid Malignancy.

Case Rep Oncol Med 2020 3;2020:1790106. Epub 2020 Feb 3.

Department of Hematology-Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Carcinoma ex pleomorphic adenoma (Ca ex PA) is a rare malignant transformation of a benign primary pleomorphic adenoma (PA). We report the case of a 62-year-old male who presented with a swelling over his left temple. Imaging revealed a lytic lesion over the left orbital wall with soft tissue extension suggestive of malignancy. Read More

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http://dx.doi.org/10.1155/2020/1790106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021468PMC
February 2020

Clinical difference between benign and malignant tumors of the hard palate.

Eur Arch Otorhinolaryngol 2020 Mar 11;277(3):903-907. Epub 2019 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun, Jeonnam, 58128, South Korea.

Objective: To determine the clinical characteristics and treatment results of benign and malignant tumors of the hard palate in our hospital.

Patients And Methods: A total of 25 patients who underwent surgical treatment for hard palate tumors between 2008 and 2018 were included in this study. Their demographic characteristics, smoking status, alcohol consumption, symptoms, duration of symptoms, size and localization of hard palate tumor, status of mucosal surface, radiologic examinations, surgery, reconstruction method, histopathologic results, treatment outcomes, oral intake start time, adjuvant treatment, postoperative complications, and recurrence were reviewed. Read More

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http://dx.doi.org/10.1007/s00405-019-05759-0DOI Listing
March 2020
1.608 Impact Factor

Diagnostic performance and inter-operator variability of apparent diffusion coefficient analysis for differentiating pleomorphic adenoma and carcinoma ex pleomorphic adenoma: comparing one-point measurement and whole-tumor measurement including radiomics approach.

Jpn J Radiol 2020 Mar 9;38(3):207-214. Epub 2019 Dec 9.

Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 1-8-1, Inohana Chuo-ku, Chiba, 260-8670, Japan.

Background And Purpose: The purpose of this study was to compare the diagnostic performance between apparent diffusion coefficient (ADC) analysis of one-point measurement and whole-tumor measurement, including radiomics for differentiating pleomorphic adenoma (PA) from carcinoma ex pleomorphic adenoma (CXPA), and to evaluate the impact of inter-operator segmentation variability.

Materials And Methods: One hundred and fifteen patients with PA and 22 with CXPA were included. Four radiologists with different experience independently placed one-point and whole-tumor ROIs and a radiomics-predictive model was constructed from the extracted imaging features. Read More

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http://dx.doi.org/10.1007/s11604-019-00908-1DOI Listing

Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2020 Jan/Feb;36(1):e1-e3

Department of Ophthalmology, University of California, San Francisco.

Primary ductal adenocarcinoma of the lacrimal gland is an aggressive neoplasm and can be seen either as a de novo malignancy or in the setting of a carcinoma ex pleomorphic adenoma. Carcinoma ex pleomorphic adenoma carries an overall unfavorable outcome; however, prognosis depends on the type and grade of the malignant component, presence of retained myoepithelial component, and extend of invasion beyond the capsule. Herein, the authors describe a 78-year-old man diagnosed with an incidental, intracapsular, high-grade ductal adenocarcinoma in situ ex pleomorphic adenoma, who is free of disease at 9 months subsequent to complete resection. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001491DOI Listing
November 2019

Cytological features of carcinoma ex pleomorphic adenoma of the salivary glands: A diagnostic challenge.

Diagn Cytopathol 2020 Feb 1;48(2):149-153. Epub 2019 Nov 1.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Carcinoma ex pleomorphic adenoma (CXPA) of the salivary glands is a relatively rare carcinoma. The detection rate of the carcinoma component in the cytological specimens is not high and may be challenging in cytological examination. The purpose of the present study was to analyze the cytological specimens of CXPA with emphasis on the detection of the carcinoma component. Read More

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http://dx.doi.org/10.1002/dc.24333DOI Listing
February 2020
1 Read

A case of carcinoma ex pleomorphic adenoma arising from multinodular pleomorphic adenoma of the buccal region.

Clin Case Rep 2019 Oct 10;7(10):1994-1998. Epub 2019 Sep 10.

Section of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan.

In multinodular lesions or tumors with mixed benign and malignant components, malignant elements may be undetectable using fine-needle aspiration biopsy/cytology in preoperative pathological diagnosis of some cases, because of sampling error. Read More

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http://dx.doi.org/10.1002/ccr3.2417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787811PMC
October 2019

Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma.

Clin Pathol 2019 Jan-Dec;12:2632010X19873384. Epub 2019 Sep 26.

Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil.

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm and, although mostly benign, recurrences, being called recurrent pleomorphic adenoma (RPA) and malignant transformation to carcinoma ex pleomorphic adenoma (CXPA), do occur. Recently, attention has been focused on molecular targeted cancer therapy in various tumors, including salivary gland tumors. The aim of this study was to investigate the role of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in PA, RPA, and CXPA. Read More

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http://dx.doi.org/10.1177/2632010X19873384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764050PMC
September 2019
1 Read

Utility of neck dissection for management of carcinoma of the parotid gland.

Br J Oral Maxillofac Surg 2019 12 26;57(10):1039-1043. Epub 2019 Sep 26.

Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT.

To validate the use of neck dissection as part of the management of patients with parotid carcinomas, we retrospectively reviewed pathological and clinical data from the head and neck pathology archive at Guy's and St Thomas' Hospital on all patients who had primary parotid carcinomas resected between 1992 and 2014. The main outcome measure was the incidence of metastatic disease. A total of 54 of the 82 patients identified had neck dissections. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.09.002DOI Listing
December 2019
3 Reads

Carcinoma ex pleomorphic adenoma of the trachea: A case report.

World J Clin Cases 2019 Sep;7(17):2623-2629

Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, Shandong Province, China.

Background: Carcinoma ex pleomorphic adenoma (CXPA) is defined as a malignant salivary gland tumor arising from a primary or recurrent pleomorphic adenoma. Only three cases of CXPA of the trachea have been reported in the literature.

Case Summary: We report a case of tracheal CXPA in a 55-year-old woman, who presented with a more than 3-mo history of progressive dyspnea. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i17.2623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745320PMC
September 2019
3 Reads

Adenoid Cystic Carcinoma of the Trachea: A Case Report.

Am J Case Rep 2019 Sep 17;20:1373-1377. Epub 2019 Sep 17.

Faculty of Medicine and Health of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.

BACKGROUND Adenoid cystic carcinoma of trachea (ACCT) is an unusual low-grade tumor from the tracheal and bronchial wall glands. The histological structure and biological behavior of ACCT are similar to that of tumors found in the salivary glands. ACCT occurs most commonly in the upper trachea, being found in the articular cartilage in the posterior aspect of the trachea. Read More

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http://dx.doi.org/10.12659/AJCR.917136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767944PMC
September 2019
7 Reads

Postoperative complications after removal of pleomorphic adenoma from the parotid gland: A long-term follow up of 297 patients from 2002 to 2016 and a review of publications.

Br J Oral Maxillofac Surg 2019 12 6;57(10):998-1002. Epub 2019 Sep 6.

Federico II University of Naples, Naples, Italy.

Pleomorphic adenomas are rounded, lumpy, capsulated lesions that are more common in women. They are typically benign, but can be associated with malignancy in a minority of cases (such as carcinoma ex pleomorphic adenoma), between 3% - 12% of the time, according to available data. The purpose of our study was to evaluate clinical outcomes in patients with benign parotid gland tumours after extracapsular dissection (ECD) or superficial parotidectomy (SP). Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.08.008DOI Listing
December 2019
3 Reads

Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival.

Am J Otolaryngol 2019 Nov - Dec;40(6):102279. Epub 2019 Aug 21.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.

Purpose: Identify variables that are independent predictors of survival in carcinoma ex pleomorphic adenoma (CXPA) of the major salivary glands using a population-based database and evaluate the incidence and management strategies for this rare malignancy.

Materials And Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for all cases of major salivary gland CXPA from 1973 to 2015.

Results: Of the 619 patients identified, the parotid gland was the most common site of involvement (76. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.102279DOI Listing
April 2020
3 Reads

Immunohistochemical features of carcinoma ex pleomorphic adenoma and pleomorphic adenoma in the lacrimal gland.

Int J Ophthalmol 2019 18;12(8):1238-1242. Epub 2019 Aug 18.

Department of Orbital Disease and Oncology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.

Aim: To investigate C-myc, Ki-67, pan-cytokeratin, and vimentin immunohistochemical features of carcinoma ex pleomorphic adenoma (Ca-ex-PA) and pleomorphic adenoma (PA) in the lacrimal gland in order to find some clues in the differential diagnosis between them.

Methods: We reviewed microscopic slides and clinical records of 64 cases of PA and 15 cases of Ca-ex-PA in the lacrimal gland. Immunohistochemical antibodies for C-myc, Ki-67, pan-cytokeratin, and vimentin were employed. Read More

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http://dx.doi.org/10.18240/ijo.2019.08.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694048PMC
August 2019
4 Reads

Metastasis of carcinoma ex pleomorphic adenoma to the brain without previous metastasis to the lungs or bones: a case report.

Br J Oral Maxillofac Surg 2019 11 9;57(9):926-928. Epub 2019 Aug 9.

Department of Molecular Oral Medicine and Maxillofacial Surgery, Division of Applied Life Science, Graduate Institute of Biomedical and Health Science, Hiroshima University; Oral and Maxillofacial Surgery, Hiroshima University Hospital.

Carcinoma ex pleomorphic adenoma is a rare type of cancer of the salivary gland that involves the malignant transformation of a primary or recurrent pleomorphic adenoma, which often metastasises to the lungs or bones, or both. To the best of our knowledge, however, nobody has reported a distant metastasis of this lesion to the brain without such previous metastasis. We report a case in a 64-year-old man. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.07.017DOI Listing
November 2019
3 Reads

Successful tri-modality treatment of atypical carcinoma ex-pleomorphic adenoma with more than 50 nodal metastases.

Oral Oncol 2019 10 8;97:151-152. Epub 2019 Aug 8.

Department of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA.

Carcinoma ex-pleomorphic adenoma (CEPA), an extremely aggressive malignant tumor, bears a significant potential for locoregional recurrence and distant metastases. Management of the disease usually involves definitive surgery with postoperative radiotherapy administered for identified nodal metastases. Two cases of CEPA with many (>50) cervical lymph node metastases and other histopathological features were managed by tri-modality treatment scheme. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.07.025DOI Listing
October 2019
1 Read

Immunohistochemical expression of mammaglobin in salivary duct carcinomas de novo and salivary duct carcinoma ex pleomorphic adenoma.

Hum Pathol 2019 10 8;92:59-66. Epub 2019 Aug 8.

Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Mammaglobin is expressed in breast and salivary gland secretory carcinomas; however, its expression in salivary duct carcinomas (SDCs) still not well established. Therefore, the aim of this study was to investigate the presence and distribution of mammaglobin immunoexpression in SDC ex-PA in different phases of the adenoma to carcinoma sequence evaluating its possible involvement in carcinogenesis and tumor progression, as well as to determine its expression in SDC de novo. Mammaglobin immunohistochemistry was performed in 84 SG tumors, including 41 pleomorphic adenomas (PA) without malignant transformation, 13 intracapsular SDC ex-PA, 5 frankly invasive SDC ex-PA, 25 SDC de novo and 10 secretory carcinomas. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.08.001DOI Listing
October 2019
5 Reads

Pleomorphic adenoma with bizarre myoepithelial cells: A diagnostic challenge on cytologic smear.

Diagn Cytopathol 2019 Dec 10;47(12):1283-1286. Epub 2019 Aug 10.

Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The diagnosis on fine needle aspiration of salivary gland tumors with a myoepithelial component is challenging because myoepithelial cells can have a wide cytomorphologic spectrum. The authors report a case of a pleomorphic adenoma of the parotid gland that expands the spectrum of appearances that myoepithelial cells can show with this tumor. A 55-year-old female was found to have a right parotid gland mass. Read More

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http://dx.doi.org/10.1002/dc.24301DOI Listing
December 2019
6 Reads

Sinonasal/nasopharyngeal pleomorphic adenoma and carcinoma ex pleomorphic adenoma: a report of 17 surgical cases combined with a literature review.

Cancer Manag Res 2019 17;11:5545-5555. Epub 2019 Jun 17.

Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, People's Republic of China.

The aim of this study was to review demographic data, location, clinical symptoms, therapeutic methods, pathological features and relapse in sinonasal/nasopharyngeal pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA). We conducted a retrospective analysis of 17 patients who were referred to our hospital during a 5-year period from 2013 to 2018. In this series, there were 7 males and 10 females. Read More

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http://dx.doi.org/10.2147/CMAR.S198942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588090PMC
June 2019
5 Reads

Anlotinib is effective in the treatment of advanced carcinoma ex pleomorphic adenoma of the submandibular gland.

Onco Targets Ther 2019 24;12:4093-4097. Epub 2019 May 24.

Department of Medical Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People's Republic of China.

Carcinoma ex pleomorphic adenoma (CXPA), a very rare malignancy found mostly in the major salivary glands, has no established standardized treatment. This report describes a 67-year-old male with advanced CXPA who was effectively treated by anlotinib. Pleomorphic adenoma of the submandibular gland was first diagnosed in 1976 after a surgical resection of a mass underneath the jaw. Read More

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http://dx.doi.org/10.2147/OTT.S200324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538880PMC
May 2019
28 Reads

The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma.

Ear Nose Throat J 2019 Sep 13;98(8):504-509. Epub 2019 Jun 13.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Carcinoma ex pleomorphic adenoma (CXPA) arises from the primary or recurrent benign pleomorphic adenoma. The purpose of this study was to evaluate the clinical features that could be referenced in the differentiation. The medical records of 221 patients with pleomorphic adenoma and 15 patients with CXPA were retrospectively reviewed. Read More

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http://dx.doi.org/10.1177/0145561319855376DOI Listing
September 2019
9 Reads

Basal Cell Adenoma of the Salivary Gland and Possible Recurrence as Basal Cell Adenocarcinoma in a Black-tailed Prairie Dog (Cynomys ludovicianus).

Authors:
K Ueda A Ueda K Ozaki

J Comp Pathol 2019 Apr 15;168:13-17. Epub 2019 Mar 15.

Laboratory of Pathology, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka, Japan. Electronic address:

We describe a black-tailed prairie dog (Cynomys ludovicianus) with a benign biphasic nodular tumour that recurred as a malignant biphasic tumour at the same site 2 years after resection. Both tumours were biphasic with regard to the glandular epithelium and basal cells and contained little of the mucus, cartilage or fibrous tissue that characterize pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. Both the first and second tumours exhibited histopathological features similar to those exhibited by human basal cell adenoma and adenocarcinoma, respectively. Read More

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http://dx.doi.org/10.1016/j.jcpa.2019.02.004DOI Listing
April 2019
9 Reads

Parotid salivary duct carcinoma: a single institution's 20-year experience.

Eur Arch Otorhinolaryngol 2019 Jul 6;276(7):2031-2038. Epub 2019 May 6.

Department of Otolaryngology, Medical University of Gdańsk, ul. Smoluchowskiego 17, 80-214, Gdańsk, Poland.

Purpose: The aim of the study was to assess the treatment results of the parotid gland salivary duct carcinoma (SDC).

Material And Methods: A retrospective clinicopathological analysis of 40 patients treated for parotid SDC in 1996-2015 was performed. The impact of following factors on 5-year disease-free survival (DFS) and overall survival (OS) was studied: age, sex, preoperative 7th nerve palsy, skin infiltration, pT, pN, surgical margin, type of parotidectomy and neck dissection, histology (SDC de novo vs. Read More

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http://dx.doi.org/10.1007/s00405-019-05454-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581927PMC
July 2019
18 Reads

Diplopia: a unique presentation of recurrence of a salivary gland carcinoma.

BMJ Case Rep 2019 May 5;12(5). Epub 2019 May 5.

Department of Otorhinolaryngology, Ninewells Hospital, Dundee, UK.

A 79-year-old man with a history of radical excision of a left submandibular gland carcinoma ex-pleomorphic adenoma presented with a new 2 cm lump in his left submandibular region which proved to be recurrence on surgical excision. During work up for revision surgery he developed a right VI cranial nerve palsy, which was attributed to his microvascular status having had a history of three previous transient ischemic attacks (TIAs). 6 months later, his palsy had not resolved. Read More

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http://dx.doi.org/10.1136/bcr-2018-225243DOI Listing
May 2019
9 Reads

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 07;43(7):984-994

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
July 2019
27 Reads

Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report.

World J Clin Cases 2019 Mar;7(6):792-797

Department of Head & Neck Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.

Case Summary: This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448082PMC
March 2019
7 Reads

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.

Hum Pathol 2019 06 1;88:66-77. Epub 2019 Apr 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with limited treatment options and poor outcome. Twenty-nine primary resected SDC, including 15 SDC de novo (SDCDN), and 14 SDC ex pleomorphic adenoma (SDCXPA) were subjected to the massive parallel sequencing assay (MSK-IMPACT) targeting 287 to 468 cancer-related genes. TP53 was the most frequently altered gene (69%). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.004DOI Listing
June 2019
22 Reads

Ossified Carcinoma Ex Pleomorphic Adenoma in accessory lobe of parotid gland: Complexity in clinical, imaging and histologic diagnosis and minimally invasive surgery.

Oral Oncol 2019 05 7;92:95-98. Epub 2019 Mar 7.

Maxillofacial Surgery Unit, Department of Maxillo-Facial Surgery, University of Naples "Federico II", Naples, Italy. Electronic address:

Carcinoma ex pleomorphic adenoma is not common among malignant salivary tumors and an accessory lobe of parotid gland tumor with a carcinoma ex pleomorphic adenoma histology is even rarer. Management of these tumors include a high index of suspicion, good understanding of the anatomy and a meticulous surgical access. The exceptional localization of an ossified Carcinoma ex Pleomorphic Adenoma in the accessory lobe of the parotid gland, never reported to date in the literature, has prompted us to report this case to stress the challenging difficulties related to clinical and histologic diagnosis and to analyze a minimally invasive intraoral approach. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.003DOI Listing
May 2019
11 Reads

Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas.

Oral Oncol 2019 03 1;90:30-37. Epub 2019 Feb 1.

Department of Head and Neck Surgery, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan. Electronic address:

Objectives: The aim of the present study was to investigate the molecular basis for the use of immune checkpoint inhibitors to treat salivary gland carcinomas (SGC).

Materials And Methods: We examined the clinical and prognostic significance of programed death ligands 1 and 2 (PD-L1 and -L2) expression using immunohistochemistry and in situ hybridization, as well as microsatellite instability (MSI) status using polymerase chain reaction, along with tumor-infiltrating lymphocytes (TILs) in 30 cases of SGC.

Results: The SGC cases studied included adenoid cystic carcinoma (AdCC, 36. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.015DOI Listing
March 2019
11 Reads

Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Am J Surg Pathol 2019 05;43(5):601-609

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001218DOI Listing
May 2019
10 Reads

Extracapsular invasion: A potential prognostic marker for Carcinoma ex-pleomorphic adenoma of the salivary glands? A Systematic Review.

J Oral Pathol Med 2019 Jul 28;48(6):433-440. Epub 2019 Feb 28.

Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Background: The aim of the present study was to integrate available data published in the literature on extracapsular invasion in cases of CXPA that correlated findings with the prognosis of analysed patients.

Methods: An electronic search was carried out at the MEDLINE/PubMed, EMBASE and Cochrane Collaboration Library databases. Articles that assessed the relationship between extracapsular invasion and survival of patients diagnosed with CXPA were selected for the systematic review. Read More

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http://dx.doi.org/10.1111/jop.12841DOI Listing
July 2019
6 Reads

Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma.

Case Rep Oncol 2018 Sep-Dec;11(3):835-841. Epub 2018 Dec 11.

Department of Medical Oncology, Sapporo Medical University, Sapporo, Japan.

Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. Read More

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http://dx.doi.org/10.1159/000495344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341428PMC
December 2018
17 Reads

Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology.

Head Neck Pathol 2020 Mar 4;14(1):246-249. Epub 2019 Jan 4.

Department of Pathology, National University Hospital, Singapore, Singapore.

We present a case of a primary 2.5 cm pleomorphic lipoma of the right parotid gland with prominent myxoid change which on FNA displayed features that mimicked a carcinoma or sarcoma ex pleomorphic adenoma. The patient was a 79 year old man with no oncological history or tumor elsewhere. Read More

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http://link.springer.com/10.1007/s12105-018-00998-9
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http://dx.doi.org/10.1007/s12105-018-00998-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021853PMC
March 2020
13 Reads

Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.

J Oral Pathol Med 2019 Mar 16;48(3):232-238. Epub 2019 Jan 16.

Department of Oral Diagnosis, Oral Pathology, Piracicaba Dental School, State University of Campinas (FOP-UNICAMP), Piracicaba, Brazil.

Background: Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors.

Methods: We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs).

Results: Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0. Read More

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http://doi.wiley.com/10.1111/jop.12820
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http://dx.doi.org/10.1111/jop.12820DOI Listing
March 2019
31 Reads

Human epithelial growth factor receptor 2 in human salivary carcinoma ex pleomorphic adenoma: a potential therapeutic target.

Cancer Manag Res 2018 30;10:6571-6579. Epub 2018 Nov 30.

Department of Oral Pathology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, People's Republic of China,

Background: To inhibit human epithelial growth factor receptor 2 (HER2) in salivary carcinoma ex pleomorphic adenoma (CXPA) and investigate the effects on tumor cell proliferation, cell cycle, and apoptosis. To assess the possibility of blocking HER2 to improve the malignant biological behavior of CXPA.

Materials And Methods: HER2 expression and amplification were examined using an immunofluorescence assay and fluorescence in situ hybridization in 2 CXPA cell lines (SM-AP1 and SM-AP4 cells). Read More

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http://dx.doi.org/10.2147/CMAR.S182652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280888PMC
November 2018
31 Reads

Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis.

Head Neck Pathol 2020 Mar 27;14(1):230-238. Epub 2018 Nov 27.

Pathology Division, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor of the salivary gland that arises from pleomorphic adenoma (PA). Squamous cell carcinoma (SCC) is extremely rare in the salivary glands. We report two cases of acantholytic SCC (ASCC) ex PA. Read More

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http://dx.doi.org/10.1007/s12105-018-0987-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021842PMC
March 2020
8 Reads

Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma.

Head Neck Pathol 2019 Dec 2;13(4):529-534. Epub 2018 Nov 2.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Salivary duct carcinoma (SDC) is an aggressive neoplasm that resembles high-grade invasive ductal carcinoma of the breast. It can develop de novo or from the malignant transformation of pleomorphic adenoma (PA). We performed immunohistochemical stains for phosphatase and tensin homologue [PTEN androgen receptor (AR)], HER2/neu, cytokeratin 5/6, estrogen receptor-beta, high-mobility group AT-hook 2 (HMGA2), and pleomorphic adenoma gene 1 (PLAG1) on tissue microarray samples of 75 SDCs and 31 adenocarcinomas, not otherwise specified (NOS). Read More

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http://link.springer.com/10.1007/s12105-018-0984-5
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http://dx.doi.org/10.1007/s12105-018-0984-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854204PMC
December 2019
40 Reads

Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features.

Histopathology 2019 Feb 2;74(3):514-525. Epub 2018 Dec 2.

Department of Human Pathology, School of Medicine, Juntendo University, Tokyo, Japan.

Aims: Pleomorphic adenoma gene 1 (PLAG1) rearrangement is well known in pleomorphic adenoma (PA), which is histologically characterised by admixed epithelial and mesenchymal components. Multiple fusion variants of PLAG1 and HMGA2 have been reported; currently, however, little is known regarding the clinicopathological impacts of these fusion types METHODS AND RESULTS: We examined the PLAG1- and HMGA2-related fusion status in 105 PAs and 11 cases of carcinoma ex PAs (CXPA) arising from salivary glands and lacrimal glands to elucidate their correlation to the clinicopathological factors. Forty cases harboured PLAG1 fusion genes: CTNNB1-PLAG1 in 22 cases, CHCHD7-PLAG1 in 14 cases and LIFR-PLAG1 in four cases. Read More

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http://dx.doi.org/10.1111/his.13759DOI Listing
February 2019
11 Reads

CD44 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma and their adjacent normal salivary glands.

Dent Res J (Isfahan) 2018 Sep-Oct;15(5):361-366

Department of Endodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: CD44 is a transmembranous proteoglycan, with a main role of cell adhesion to other cells and to extracellular matrix involved in the preservation of three-dimensional structure of organs. Pleomorphic adenoma (PA) is a common benign salivary gland tumor, composed of myoepithelial and ductal components. Carcinoma ex-PA (CXPA) is malignant transformation of the epithelial elements in PA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134731PMC
September 2018
12 Reads

Surgical treatment results of parapharyngeal space tumors: a report of 22 cases.

Otolaryngol Pol 2018 May;72(4):9-16

Medical University of Warsaw Otolaryngology Depatment.

Introduction: Parapharyngeal space (PPS) is the anatomical area lateral to the upper pharynx and clinically important due to PPS tumors. They account for less than 1% of head and neck neoplasms. Both benign and malignant neoplasms may arise there and typical for this localization is diversity of histological origin. Read More

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http://dx.doi.org/10.5604/01.3001.0012.0485DOI Listing
May 2018
46 Reads

Lacrimal gland tumors in Turkey: types, frequency, and outcomes.

Int J Ophthalmol 2018 18;11(8):1296-1302. Epub 2018 Aug 18.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Aim: To evaluate the clinical, radiological, and treatment features of lacrimal gland tumors.

Methods: Retrospective review of 99 eyes of 92 patients with lacrimal gland tumors diagnosed and managed in a single institution between January 1999 and March 2017. Clinical and radiological features, histopathology, treatment methods, and prognosis were evaluated. Read More

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http://dx.doi.org/10.18240/ijo.2018.08.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090115PMC
August 2018
15 Reads

Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):77-84

Medical Oncology Service, St Bartholomew's Hospital, London, United Kingdom.

Purpose: To ascertain long-term outcome of treatment for primary epithelial malignancies of the lacrimal gland and compare outcomes after cranio-orbital resection or after macroscopic tumor resection with radiotherapy.

Methods: Comparative case series of 79 patients (49 male; 62%) treated for primary epithelial malignancies of the lacrimal gland at Moorfields Eye Hospital between 1972 and 2014. Patients were identified from clinical and pathological databases and, where available, the clinical, pathological, and imaging records reviewed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001177DOI Listing
December 2019
30 Reads

Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma.

Oral Oncol 2018 09 30;84:106-107. Epub 2018 Jul 30.

Departmento de Anatomia Patológica, Universidade Estadual de Campinas, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2018.07.003DOI Listing
September 2018
13 Reads