562 results match your criteria Carcinoma Ex Pleomorphic Adenoma


Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management.

Medeni Med J 2022 Jun;37(2):194-202

Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Salivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal translocations, such as CRTC1/3-MAML2 in mucoepidermoid carcinoma, g MYB-NFIB gene fusions in adenoid cystic carcinoma, and PLAG1-HMGA2 gene changes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Read More

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Increased MIB-1 expression in salivary gland pleomorphic adenoma that recurs and undergoes malignant transformation.

Sci Rep 2022 May 30;12(1):9029. Epub 2022 May 30.

Department of Pathology, HUSLAB, Helsinki University Hospital and University of Helsinki, PO Box 21, 00014, Helsinki, Finland.

The objective of this retrospective study was to explore possible changes in histopathological features and expression of cyclin D1 and MIB-1 in salivary gland pleomorphic adenoma (PA) that recur or undergo malignant transformation. Knowledge of these characteristics might help to guide the management of these rare tumors. The histopathology and immunohistochemical staining characteristics of such tumors were analyzed in a cohort of 65 patients constituting three different groups of tumors: PA, recurrent pleomorphic adenoma (RPA) and carcinoma ex PA (CxPA). Read More

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Response to Miles Kiernan Re: a rare case of mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland.

Orbit 2022 May 29. Epub 2022 May 29.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Our goal is to contribute to the medical literature with our case of CEPA and hope to better help fellow clinicians diagnose and treat these rare tumors. Read More

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Role of HER2 in Prognosis of Salivary Duct Carcinoma: A Systematic Review and Meta-Analysis.

Laryngoscope 2022 May 14. Epub 2022 May 14.

Department of Otolaryngology, Head and Neck Surgery, Southern Illinois University, Springfield, Illinois, U.S.A.

Objectives: Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with a poor prognosis. These tumors frequently stain positive for HER2/ErbB2, but data on the prognostic significance of HER2 status in SDC are mixed. We sought to determine whether HER2 status affects survival outcomes in SDC. Read More

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Epithelial-myoepithelial carcinoma ex pleomorphic adenoma of the parotid gland with unique histologic differentiation: A rare case report.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S34-S39. Epub 2022 Feb 28.

Oral Medicine and Radiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.

Epithelial myoepithelial carcinoma (EMC) is an uncommon low-to-intermediate grade salivary gland malignancy that accounts for 1% of all tumors arising in salivary glands. About 80% of these tumors affect the parotid gland. These lesions either arise or from existing pleomorphic adenoma (PA). Read More

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February 2022

Management of malignant submandibular gland tumors: A 30-year experience from a single center.

Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb 4. Epub 2022 Feb 4.

Division of Radiation Oncology, Department of Radiotherapy and Medical Oncology, University Hospital for Tumors, University Hospital Center "Sisters of Mercy", Zagreb, Croatia.

Objective: Owing to histologic heterogeneity, biological behavior, and rarity, recommendations for the treatment of malignant submandibular gland tumors (MSGT) are inconsistent. The aim of this study was to present a single-center experience in the treatment of MSGT with an emphasis on surgical treatment, including indication on elective neck dissection (END).

Study Design: Twenty-four MSGT were primary surgically treated (gland excision with neck dissection). Read More

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February 2022

Squamous Cell Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: Unusual Entity and Diagnostic Pitfalls.

Cancer Diagn Progn 2021 Sep-Oct;1(4):279-283. Epub 2021 Jul 3.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, U.S.A.

Background: Carcinoma ex pleomorphic adenoma (PA) of the salivary gland with squamous cell carcinoma (SCC) component is extremely rare and can be easily misdiagnosed as a benign PA or SCC (primary or metastatic).

Case Report: A 75-year-old male who had no significant past medical history, presented with a rapid growing right parotid gland mass. A fine needle aspiration revealed malignant cells. Read More

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The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi-institutional retrospective analysis in Japan.

Head Neck 2022 06 29;44(6):1430-1441. Epub 2022 Mar 29.

Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.

Background: Salivary duct carcinoma (SDC) is a high-grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC.

Methods: We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes. Read More

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Response to "A rare case of mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland".

Authors:
Miles Kiernan

Orbit 2022 Mar 8:1-2. Epub 2022 Mar 8.

Adnexal Service, Moorfields Eye Hospital, London, UK.

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Salivary duct carcinoma: A report of 70 FNA cases and review of the literature.

Authors:
Paul E Wakely

Cancer Cytopathol 2022 Mar 7. Epub 2022 Mar 7.

Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio.

Background: Although usually recognized as malignant, fine-needle aspiration (FNA) biopsy of salivary duct carcinoma (SDC) has been confused with other primary salivary gland (SG) neoplasms. This article undertook an analysis of a large collection of SDC FNA cases to assess diagnostic accuracy, specificity, and cytopathology.

Methods: Cytopathology files were searched for SDC with histopathologic validation. Read More

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Carcinoma ex pleomorphic adenoma of the submandibular gland: A retrospective analysis of 86 patients.

Oral Dis 2022 Feb 24. Epub 2022 Feb 24.

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: To evaluate the prognostic and locoregional metastatic features of carcinoma ex pleomorphic adenoma of submandibular gland (SMG-CXPA) and improve the understanding of this uncommon condition.

Patients And Methods: We retrospectively reviewed patients who were diagnosed with SMG-CXPA. The survival data of SMG-CXPA patients were statistically analyzed using Cox regression and Kaplan-Meier method. Read More

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February 2022

Comparison of gene fusion detection methods in salivary gland tumors.

Hum Pathol 2022 05 17;123:1-10. Epub 2022 Feb 17.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, United States.

Salivary gland neoplasms may pose diagnostic difficulties due to overlapping morphologic features. Recently, specific gene fusions have been discovered that correspond to particular tumor types, and can aid in accurate diagnosis. Gene rearrangements are commonly assessed by fluorescence in situ hybridization (FISH), although use of next-generation sequencing is increasing. Read More

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Carcinoma ex pleomorphic adenoma of the parotid gland.

Am J Otolaryngol 2022 Mar-Apr;43(2):103389. Epub 2022 Feb 3.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hwasun Hospital, Hwasun, South Korea.

Introduction: Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant tumor of the parotid gland. We analyzed the clinical characteristics and treatment outcomes of CXPA of the parotid gland in patients managed for 11 years at this hospital.

Methods: The study included 17 cases of CXPA of the parotid gland from January 2010 to December 2020. Read More

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Glial Fibrillary Acidic Protein Expression Helps Distinguish Pleomorphic Adenoma from Histologic Mimics.

Head Neck Pathol 2022 Jan 22. Epub 2022 Jan 22.

Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada.

Pleomorphic adenoma (PA) is the most common biphasic type of salivary gland tumour to arise in adults. It is a biphasic tumour composed of both luminal (ductal) cells and abluminal (basal and myoepithelial) cells. Other biphasic salivary gland type tumours, both benign and malignant, can mimic PA, especially on small biopsies. Read More

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January 2022

Adjuvant radiotherapy in malignant tumors of parotid. Experience of the Navarra Hospital Complex.

Rep Pract Oncol Radiother 2021 30;26(6):962-967. Epub 2021 Dec 30.

Maxillofacial Surgery Services, Navarra Hospital Complex, Pamplona, Spain.

Background: The objective of the study was to review the outcome of patients with parotid cancer treated with postoperative radiotherapy at Complejo Hospitalario de Navarra in the last ten years.

Materials And Methods: We retrospectively reviewed patients treated with adjuvant radiotherapy between January 2008 and December 2018. We analyzed demographic data, histopathologic findings, local control (LC) and overall survival (OS). Read More

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December 2021

Frankly Invasive Carcinoma Ex-intraductal Carcinoma: Expanding on an Emerging and Perplexing Concept in Salivary Gland Tumor Pathology.

Head Neck Pathol 2022 Jan 5. Epub 2022 Jan 5.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Intraductal carcinoma (IDC) of the salivary glands is an uncommon and enigmatic tumor, our understanding of which is rapidly evolving. Recent studies have demonstrated multiple IDC subtypes and consistent gene fusions, most frequently involving RET. Because IDC is a ductal proliferation surrounded by flattened myoepithelial cells, it was previously presumed to be analogous to breast ductal carcinoma in situ, but recent evidence has shown that the myoepithelial cells of fusion-positive IDC harbor the same genetic alterations of the ductal cells and are therefore neoplastic. Read More

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January 2022

A rare case of mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland.

Orbit 2021 Dec 23:1-5. Epub 2021 Dec 23.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Carcinoma ex pleomorphic adenoma (CEPA) of the lacrimal gland is a rare malignant tumor that arises from a pre-existing pleomorphic adenoma. Lacrimal gland CEPA with mucoepidermoid histological subtype is exceedingly rare. Diagnosis can be aided by radiographic findings, though the gold standard is histopathological analysis following excisional biopsy. Read More

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December 2021

Aspiration cytology of pleomorphic adenoma with squamous metaplasia: A case series and literature review illustrating diagnostic challenges.

Diagn Cytopathol 2022 Feb 20;50(2):64-74. Epub 2021 Dec 20.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

Objective: Squamous metaplasia is not uncommonly observed in salivary gland neoplasms, including pleomorphic adenomas (PAs). It poses as a diagnostic pitfall with cytomorphologic features overlapping with low-grade epithelial malignances and carcinoma ex-PA. We report series of aspirates of PAs with squamous metaplasia and review the literature for the clinicopathological and cytologic features of this diagnostically challenging entity. Read More

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February 2022

Discovery proteomics reveals potential protein signature associated with malignant phenotype acquisition in pleomorphic adenoma.

Oral Dis 2021 Dec 13. Epub 2021 Dec 13.

Pathology Department, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.

Objective: To analyze the proteomic profile of salivary pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) samples and correlate them with the malignant transformation of the PA.

Materials And Methods: Thirty samples (10 PA, 16 CXPA, and 4 residual PA) were microdissected and submitted to liquid chromatography-tandem mass spectrometry (LC-MS/MS). The proteomic data and protein identification were analyzed through LC-MS/MS spectra using the MaxQuant software. Read More

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December 2021

Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland.

Int J Mol Sci 2021 Nov 23;22(23). Epub 2021 Nov 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki-City 569-8686, Japan.

Incomplete excision of pleomorphic adenoma (PA) may result in recurrent pleomorphic adenoma (RPA). Furthermore, long-term neglected PA may become carcinoma ex pleomorphic adenoma (CXPA). In the present study, the relationships between mast cell-derived chymase and these tumors were examined. Read More

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November 2021

Analysis of clinicopathologic features and expression of NR4A3 in sinonasal acinic cell carcinoma.

Mod Pathol 2022 05 6;35(5):594-600. Epub 2021 Dec 6.

ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Acinic cell carcinoma (AiCC) in the nasal cavity and paranasal sinuses has rarely been reported in literature. A recent study demonstrated that recurrent genomic rearrangement [t(4;9) (q13;q31)] is a driver event in AiCC of the salivary glands that could promote the upregulation of transcription factor nuclear receptor subfamily 4 group A member 3 (NR4A3). In the current study, we evaluated the clinicopathological characteristics and expression of NR4A3 in four new cases of sinonasal AiCC. Read More

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Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.

Head Neck 2022 02 4;44(2):505-517. Epub 2021 Dec 4.

Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

We defined the occult nodal metastasis (ONM) rate of clinical node-negative salivary gland malignancies and examined the role of elective neck dissection (END). Meta-analysis querying four databases, from inception of databases to March 25th, 2020. Fifty-one studies with 11 698 patients were included. Read More

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February 2022

Genomic alteration in rare subtype of sarcomatoid salivary duct carcinoma.

Pathol Res Pract 2021 Dec 29;228:153678. Epub 2021 Oct 29.

Departments of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. Electronic address:

Aims: Salivary duct carcinoma (SDC) is an aggressive salivary gland neoplasm with a poor prognosis. Morphologically, it has many variants including sarcomatoid SDC. We evaluated the morphological features, immunohistochemistry profile, and genomic alteration of the rare variant, sarcomatoid SDC. Read More

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December 2021

Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands.

Int Ophthalmol 2022 Apr 10;42(4):1101-1109. Epub 2021 Nov 10.

Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Purpose: To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG).

Methods: Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases. Read More

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Expanding the clinicopathological spectrum of TGFBR3-PLAG1 rearranged salivary gland neoplasms with myoepithelial differentiation including evidence of high-grade transformation.

Genes Chromosomes Cancer 2022 02 17;61(2):94-104. Epub 2021 Nov 17.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

PLAG1 rearrangements have been described as a molecular hallmark of salivary gland pleomorphic adenoma (PA), carcinoma ex pleomorphic adenoma (CEPA), and myoepithelial carcinoma (MECA). Several fusion partners have been described, however, commonly no further assignment to the aforementioned entities or a morphological prediction can be made based on the knowledge of the fusion partner alone. In contrast, TGFBR3-PLAG1 fusion has been specifically described and characterized as an oncogenic driver in MECA, and less common in MECA ex PA. Read More

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February 2022

The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas.

Tumour Biol 2021 ;43(1):249-259

Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background.

Objective: This study focuses on the potential presence of herpes-, polyoma- and parvoviruses in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and carcinoma ex pleomorphic adenoma (CaxPA). Read More

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October 2021

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.

Am J Clin Pathol 2022 Jan;157(1):98-108

Department of Pathology and Laboratory Medicine, New York Presbyterian-Weill Cornell Medicine, New York, NY, USA.

Objectives: Salivary gland acinic cell carcinoma (AciCC) has recognizable cytomorphologic features that can overlap with benign and malignant entities, creating a diagnostic challenge. AciCC harbors a t(4;9) translocation increasing nuclear receptor subfamily 4 group A member 3 (NR4A3) expression, detectable by immunohistochemistry (IHC) on surgical resection (SR). NR4A3 IHC cytology data are limited. Read More

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January 2022

Malignant transformation of salivary gland pleomorphic adenoma: proof of principle.

J Pathol Clin Res 2021 Sep 7;7(5):432-437. Epub 2021 May 7.

Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Supposed risk of malignant transformation of salivary gland pleomorphic adenoma (SGPA) is an important reason for aggressive retreatment in recurrent pleomorphic adenoma (RPA). However, although the diagnostic category 'carcinoma ex-pleomorphic adenoma' suggests that malignant transformation of a pleomorphic adenoma is a regular event, this has to date not been shown to occur in sequential lesions of one patient. Here, we show the molecular events in transformation to malignancy of a pleomorphic adenoma of the parotid gland. Read More

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September 2021

Palpebral carcinoma -pleomorphic adenoma.

Orbit 2021 Jul 29. Epub 2021 Jul 29.

Adnexal Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

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