524 results match your criteria Carcinoma Ex Pleomorphic Adenoma

Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression.

Head Neck Pathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology, University of New Mexico School of Medicine, University of New Mexico, MSC08 4640, Albuquerque, NM, 87131, USA.

Myoepithelial carcinoma (MECA) is a rare salivary gland (SG) neoplasm (0.1-0.45% of all SG tumors) that often presents with bland cytomorphology and can be misclassified as cellular pleomorphic adenoma (PA) or myoepithelioma. Read More

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Nasopharyngeal carcinoma ex-pleomorphic adenoma (noninvasive): A report of a rare case.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S58-S60. Epub 2021 Mar 19.

Department of ENT, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Pleomorphic adenoma (PA) is the most common type of benign tumors of minor salivary glands. A carcinoma ex-pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm originating from either a primary or recurrent benign PA. The nasopharynx is an extremely uncommon location for this tumor. Read More

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Role of positron emission tomography in primary carcinoma ex pleomorphic adenoma of the bronchus: A case report.

World J Clin Cases 2021 Apr;9(12):2811-2815

Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan.

Background: Primary carcinoma ex pleomorphic adenoma arising from the tracheobronchial system is rarely reported.

Case Summary: We present a patient with primary carcinoma ex pleomorphic adenoma of the bronchus and review the associated literature for further comparison, including age, clinical manifestations, and diagnostic process. This patient had no history of neoplasms of the salivary gland. Read More

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Expression of p16 protein in pleomorphic adenoma and carcinoma ex pleomorphic adenoma proves diversity of tumour biology and predicts clinical course.

J Clin Pathol 2021 May 3. Epub 2021 May 3.

Department of Otolaryngology and Laryngological Oncology, Poznan University of Medical Sciences, Poznan, Poland.

Aims: The aim of the study is to correlate p16 expression with the clinical courses of pleomorphic adenoma (PA), its malignant transformation (CaexPA) and treatment outcomes.

Methods: Retrospective analysis (1998-2019) of 47 CaexPA, 148 PA and 22 normal salivary gland samples was performed. PAs were divided into two subsets: clinically 'slow' tumours characterised by stable size or slow growth; and 'fast' tumours with rapid growth rate. Read More

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The role of immune surveillance in malignant transformation of benign salivary gland tumors.

Oncotarget 2021 Mar 30;12(7):592-595. Epub 2021 Mar 30.

Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). Recently, genomic analyses have provided deeper insights into the molecular biology of salivary gland cancers. However, the molecular processes that underlie the progression from PA to CA exPA are largely unknown. Read More

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Masses of the Lacrimal Gland: Evaluation and Treatment.

J Neurol Surg B Skull Base 2021 Feb 18;82(1):100-106. Epub 2021 Feb 18.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States.

Lacrimal gland lesions account for approximately 9 to 10% of all biopsied orbital masses. Potential causes include nongranulomatous and granulomatous inflammation, autoimmune disease, lymphoproliferative disorders, benign epithelial proliferation, malignant neoplasia, and metastatic disease. Inflammatory lesions and lymphoproliferative disorders are the most common and may be unilateral or bilateral; they may also be localized to the orbit or associated with systemic disease. Read More

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February 2021

Secretory carcinoma ex pleomorphic adenoma of the submandibular gland: An immunohistochemical study.

Oral Oncol 2021 Mar 25:105262. Epub 2021 Mar 25.

Pathological Anatomy Department, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address:

Male patient 60-year-old was referred from another service for expert review of a lesion in the submental region. Pathological review revealed morphological features compatible with salivary gland Secretory carcinoma (SC) in cervical lymph node. The patient underwent removal of the left submandibular gland, left neck dissection and biopsy of left labial commissure region. Read More

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Salivary duct carcinoma and small cell carcinoma ex-pleomorphic adenoma: A heretofore undescribed entity and the naming conundrum: MiNEN, combined, collision, or composite tumor?

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jan 28. Epub 2021 Jan 28.

Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Carcinoma with dual neuroendocrine and non-neuroendocrine components are recognized albeit a rare occurrence among the head and neck tumours. Owing to a disjointed pathology taxonomy and a lack of defining criteria, these tumors have remained underrecognized and poorly understood by pathologists and oncologists. Herein, we present a heretofore unreported case of a mixed neuroendocrine non-neuroendocrine carcinoma occurring as a carcinoma ex-pleomorphic adenoma (CXPA) in the soft palate of a 32-year-old man. Read More

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January 2021

Nasopharyngeal Carcinoma Ex Pleomorphic Adenoma: Case Report and Comprehensive Literature Review.

Case Rep Otolaryngol 2021 26;2021:8892280. Epub 2021 Feb 26.

State University of New York at Buffalo, Department of Otolaryngology-Head and Neck Surgery, Buffalo, NY, USA.

Carcinoma ex pleomorphic adenoma (CXPA) is an epithelial malignancy that transforms from benign pleomorphic adenomas (PA) at a rate of 1.5% after 5 years and 10% after 15 years. The average age of reported nasopharyngeal CXPA is 56. Read More

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February 2021

BOC-PLAG1, a new fusion gene of pleomorphic adenoma: Identified in a fine-needle aspirate by RNA next-generation sequencing.

Diagn Cytopathol 2021 Jun 12;49(6):790-792. Epub 2021 Mar 12.

Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Fine-needle aspiration (FNA) of PA exhibits variable combinations of bland ductal epithelial cells, myoepithelial cells, and characteristic magenta fibrillary stroma on Diff-Quik/Romanowsky stain. However, a cellular PA with scant chondromyxoid stroma can be a diagnostic challenge on FNA. Read More

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Carcinoma Expleomorphic Adenoma of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2021 Mar 8. Epub 2021 Mar 8.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To report the characteristics and long-term outcomes of patients presenting with carcinoma ex-pleomorphic adenoma (CXPA) or malignant mixed tumor of the lacrimal gland.

Methods: A retrospective case-note review for patients with CXPA, seen at Moorfields Eye Hospital between 1985 and 2018, was performed for demographics, presentation, imaging, histopathology, management, and outcome.

Results: Twenty-six patients (11 male; 42%) presented at a mean age of 46 years (median 46. Read More

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Enhanced Angiogenesis in Salivary Duct Carcinoma Ex-Pleomorphic Adenoma.

Front Oncol 2020 22;10:603717. Epub 2021 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Salivary duct carcinoma (SDC) is morphologically similar to breast cancer, with HER2-overexpression reported. With regard to the pattern of disease onset, SDC can arise from or carcinoma ex-pleomorphic adenoma (Ca-ex-PA). Recently, multiple molecular profiles of SDC as well as breast cancer have been reported, with significant differences in HER2 expression between Ca-ex-PA and . Read More

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February 2021

Surgery combined with I brachytherapy for treatment of carcinoma ex pleomorphic adenoma of the parotid gland.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Apr 8;131(4):395-404. Epub 2020 Dec 8.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology. Electronic address:

Objective: The aim of this study was to investigate the effectiveness and safety of surgery combined with I seed brachytherapy for treatment of carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland and to identify the factors associated with prognosis.

Study Design: We conducted a retrospective analysis of data of patients with CXPA of the parotid gland treated with surgery plus I seed brachytherapy at the Peking University School of Stomatology Hospital between December 2003 and July 2018.

Results: Fifty-five patients (median age, 51 years) were included in the study. Read More

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Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.

BMC Cancer 2021 Feb 18;21(1):178. Epub 2021 Feb 18.

Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Early detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage at diagnosis is a very strong indicator of prognosis in PGC. Nevertheless, some patients still present with large parotid mass, maybe due to the unawareness or ignorance of their disease. In this study, we aimed to present the clinical outcomes of bulky PGC (defined by a 4 cm cutoff point for T3-4 versus T1-2 tumors), to emphasize the necessity of a self-examination tool for parotid gland tumor. Read More

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February 2021

Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma.

Head Neck Pathol 2021 Feb 16. Epub 2021 Feb 16.

Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, Bologna, Italy.

The presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. Read More

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February 2021

Salivary Duct Carcinoma With Rhabdoid Features-No or Aberrant Expression of E-cadherin and Genetic Changes in CDH1: Immunohistochemical and Genetic Analyses of 17 Cases.

Am J Surg Pathol 2021 04;45(4):439-449

Department of Pathology, Shizuoka General Hospital, Shizuoka City.

Salivary duct carcinoma is a relatively uncommon malignancy of the salivary glands; however, it frequently occurs as a carcinomatous component of carcinoma ex pleomorphic adenoma. We previously reported salivary duct carcinoma with rhabdoid features (SDCRF) as an extremely rare subtype of salivary duct carcinoma, and that it occurred as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). We collected new cases of SDCRF for this study, in which we examined a total of 17 cases immunohistochemically and genetically. Read More

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Mixed response and mechanisms of resistance to larotrectinib in metastatic carcinoma ex pleomorphic adenoma of the parotid harboring an NTRK2 fusion: A case report.

Medicine (Baltimore) 2021 Jan;100(4):e24463

Swiss Tumor Molecular Institute, Zurich, Switzerland.

Introduction: Standardized systemic treatment options are lacking for carcinoma ex pleomorphic adenoma, which is a rare and aggressive tumor primarily found in salivary glands.Here we report the case of a 63-year-old male with carcinoma ex pleomorphic adenoma of the left parotid and parapharyngeal space harboring a neurotrophic receptor tyrosine kinase (NTRK) 2 fusion who was treated with a small molecule inhibitor that targets the tropomyosin receptor kinase (TRK) proteins. To the best of our knowledge, no similar case has been described in the literature so far. Read More

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January 2021

Myoepithelial Carcinoma.

Bin Xu Nora Katabi

Surg Pathol Clin 2021 Mar 5;14(1):67-73. Epub 2021 Jan 5.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

Myoepithelial carcinoma (MECA) may overlap histologically with other salivary gland neoplasms, especially pleomorphic adenoma. MECA is characterized by cellular, uniform growth of myoepithelial cells and multinodular expansile invasive pattern with zonal cellular distribution. It may arise de novo or in association with pleomorphic adenoma (myoepithelial carcinoma ex pleomorphic adenoma). Read More

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Carcinoma Ex-Pleomorphic Adenoma Diagnosis During Global Health Engagement Operations.

Mil Med 2021 01;186(Suppl 1):828-832

Department of Otolaryngology-Head and Neck Surgery.

Introduction: In global health engagement settings, performance of oncologic surgery is evaluated by understanding the host nation healthcare capacity to include inpatient care support and the available postoperative adjunctive therapy to include chemotherapy and radiation therapy.

Materials And Methods: We present a case during Pacific Partnership 2018 of a patientwith a malignant facial mass diagnosed postoperatively. A literature review was conducted, searching specifically for cases related to pleomorphic adenoma (PA), carcinoma ex-PA, cases of misdiagnosis, and global health engagement operations. Read More

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January 2021

The Diagnostic Utility of RAS Q61R Mutation-specific Immunohistochemistry in Epithelial-Myoepithelial Carcinoma.

Am J Surg Pathol 2021 Jul;45(7):885-894

Departments of Anatomic Pathology.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland cancer characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety and overlap of histologic features with other salivary gland tumors, there are broad differential diagnoses. The HRAS Q61R mutation has been reported to be frequent in and specific to EMC. Read More

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Parapharyngeal space carcinoma ex pleomorphic adenoma: case report and literature review.

Braz J Otorhinolaryngol 2021 Jan 2. Epub 2021 Jan 2.

University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital, Department of Otolaryngology & Head and Neck Surgery, Turkey.

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January 2021

Primary and Secondary/ Metastatic Salivary Duct Carcinoma Presenting within the Sinonasal Tract.

Head Neck Pathol 2021 Jan 11. Epub 2021 Jan 11.

Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA, 15213, USA.

Traditionally, sinonasal adenocarcinomas have been subdivided into intestinal (ITAC) and non-intestinal (non-ITAC) categories. The latter encompasses salivary-type adenocarcinomas originating from the seromucinous glands of the sinonasal mucosa and non-salivary adenocarcinomas. The non-salivary adenocarcinoma category is further subdivided into low-and high-grade variants. Read More

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January 2021

Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.

Adv Anat Pathol 2021 03;28(2):81-93

Department of Molecular Pathology, Graduate School of Health Sciences, Dokuz Eylul University, Izmir, Turkey.

Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chromosomal rearrangements including CRTC1-MAML2 and CRTC3-MAML2 in mucoepidermoid carcinoma, MYB-NFIB and MYBL1-NFIB fusions in adenoid cystic carcinoma, PLAG1 and HMGA2 alterations in pleomorphic adenoma and carcinoma ex pleomorphic adenoma, ETV6-NTRK3 and ETV6-RET in secretory carcinoma, EWSR1-ATF1 and EWSR1-CREM in clear cell carcinoma, provide new insights into the molecular pathogenesis of various salivary gland neoplasms and help to better classify them. Read More

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Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Maxillary Sinus: A Case Report and Review of Literature.

Head Neck Pathol 2021 Jan 4. Epub 2021 Jan 4.

Department of Surgery and Biomedical Sciences, Section of Maxillo-Facial Surgery, University of Perugia, Piazzale Gambuli 1, 06129, Perugia, Italy.

Myoepithelial carcinoma ex pleomorphic adenoma is defined as a malignant epithelial neoplasm arising from a primary or recurrent benign pleomorphic adenoma. This type of tumor comprises 3.6% of all salivary gland tumors and 12% of malignant ones. Read More

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January 2021

Corrigendum: High grade carcinoma ex pleomorphic adenoma of parotid gland: a case report.

J Korean Assoc Oral Maxillofac Surg 2020 Dec;46(6):445

Department of Pathology, Dankook University College of Medicine, Cheonan, Korea.

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December 2020

Pleomorphic adenoma: the great mimicker of malignancy.

Histopathology 2020 Dec 27. Epub 2020 Dec 27.

Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA.

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm, and its diagnosis is straightforward in the majority of cases. However, not infrequently, PA shows unusual and uncommon histological features that can be confused with those of malignancy. The difficulties in diagnosing PA arise from its ability to mimic invasion, show atypical or metaplastic cytomorphology, and show morphological features that overlap with those of established salivary gland carcinomas. Read More

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December 2020