Search Our Scientific Publications & Authors

J Nucl Med 2022 May 19. Epub 2022 May 19.

Nuclear Medicine and Molecular Imaging, Institut de Cancérologie Strasbourg Europe (ICANS), France.

To compare the respective value of Ga-DOTATOC and F-DOPA PET/CT for initial staging or pre-surgical work-up of patients with small intestine neuroendocrine tumors (SiNET). This is a retrospective, multicenter, non-interventional investigation involving 53 non-operated SiNET patients who underwent both Ga-DOTATOC and F-DOPA PET/CT within a 6-months interval without therapeutic intervention or change between the two PET/CT studies. Detection rate (DR %) was calculated according to per-region and per-lesion analyses. Read More

Endocr Connect 2022 Apr 1. Epub 2022 Apr 1.

T Walter, Service d'oncologie digestive, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.

Purpose: To improve neuroendocrine neoplasm (NEN) management, the European Neuroendocrine Tumor Society (ENETS) recognised 62 Centers of Excellence (CoE). This retrospective study compares conformity of patients' initial management within vs outside an ENETS CoE with clinical practice guidelines (CPGs).

Methods: Patients diagnosed with a NEN between August 2018 and July 2020 and presented in the Lyon-CoE Multidisciplinary Tumour Board (MDT) were included. Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373

Department of Pathology, Anyang Tumor Hospital, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang, Henan, China.

Purpose: To investigate the clinicopathological features of mature teratoma with malignant transformation.

Methods: Retrospectively analysis of 1179 cases mature teratoma was done from August 1999 to December 2019 in Institution. 14 cases of mature teratoma with malignant transformation were discussed mainly for the pathological characteristics and clinical manifestations. Read More

Eur J Case Rep Intern Med 2022 14;9(3):003231. Epub 2022 Mar 14.

Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Small bowel tumours are rare, representing about 0.5% of all tumours and about 3% of gastrointestinal tract tumours. The low prevalence contrasts with the vast surface area of the small intestine, which accounts for over 90% of the surface area of the digestive tract. Read More

Cancers (Basel) 2022 Mar 10;14(6). Epub 2022 Mar 10.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.

Therapeutic advancements in neuroendocrine tumors (NETs) have improved survival outcomes. This study aims to review the impact of the current therapeutics on health-related quality of life (HRQoL) in NET patients. A literature review was performed utilizing PubMed, The Cochrane Library, and EMBASE, using the keywords "Carcinoid", "Neuroendocrine tumor", "NET", "Quality of life", "Chemotherapy", "Chemoembolization", "Radiofrequency ablation", "Peptide receptor radionucleotide therapy", "PRRT", "Surgery", "Everolimus", "Octreotide", "Lanreotide", "Sunitinib", and "Somatostatin analog". Read More

BMC Womens Health 2022 03 17;22(1):76. Epub 2022 Mar 17.

Department of Pathology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan, 430071, Hubei Province, People's Republic of China.

Background: Primary ovarian carcinoid is a very rare ovarian low-grade neuroendocrine tumor, accounting for about 0.1% of all ovarian neoplasms.

Case Presentation: We reported a case of primary ovarian carcinoid arising from a mature cystic teratoma in a 50-year-old woman. Read More

J Drugs Dermatol 2022 Mar;21(3):315-316

A 61-year-old Caucasian male with a medical history of metastatic carcinoid presented to dermatology with a new onset severely pruritic “breakouts” on the arms, neck, and chest. Approximately ten years prior, he was diagnosed with a small bowel carcinoid tumor and liver metastases treated with a combination of resection and ablation. Read More

Cancer Biol Ther 2022 12;23(1):96-102

Early Discovery and Technology Development, Ksilink, Strasbourg, France.

Lung carcinoids are neuroendocrine tumors representing 1 to 2% of lung cancers. This study outlines the case of a patient with a metastatic lung atypical carcinoid who presented with a pleural effusion and progression of liver metastases after developing resistance to conventional treatments. Personalized functional profiling (PFP), i. Read More

Cir Cir 2022 ;90(1):120-123

Servicio de Cirugía General, Hospital Regional Tlalnepantla, Instituto de Seguridad Social del Estado de México y Municipios, Tlalnepantla de Baz, Estado de México, México.

Cecal appendix tumors are extremely rare (less than 0.5%), with carcinoid tumors being described as the most common type of appendix tumor. A case of a 32-year-old male patient is reported, with no significant pathological history, with acute abdomen data. Read More

J Neuroendocrinol 2022 Apr 25;34(4):e13092. Epub 2022 Jan 25.

Service de Gastroentérologie et d'Oncologie Médicale, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.

The annual prevalence of metastatic neuroendocrine tumours (mNETs) is rising, leading to significant healthcare costs. The present study aimed to describe healthcare resource use (HRU) and the corresponding costs among patients with mNETs, according to primary tumour location, functioning status and type of treatments. The LyREMeNET study included consecutive mNET patients with a diagnosis performed between January 2010 and December 2017, who were seen at least once in the ENETS center of excellence in Lyon. Read More

World J Gastrointest Endosc 2021 Dec;13(12):593-606

Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United

Composite intestinal adenoma-microcarcinoid (CIAM) is a rare intestinal lesion consisting of conventional adenoma and small, well differentiated carcinoid [microcarcinoid (MC)] at its base. The incidence of CIAM is 3.8% in surgically resected colorectal polyps. Read More

Gan To Kagaku Ryoho 2021 Dec;48(13):1579-1581

Dept. of Surgery, Minami Osaka Hospital.

A 56-year-old woman complaining of right lower abdominal pain was admitted to our hospital. An abdominal computed tomography showed the enlarged appendix tip and a high density area around the appendix to retroperitoneum. The patient was diagnosis with acute appendicitis and underwent emergency laparoscopic appendectomy. Read More

Rev Esp Enferm Dig 2022 03;114(3):183-184

Cirugía General y del Aparato Digestivo, Hospital Universitario Torrecárdenas, España.

We have read with interest the article by Pérez Montiel CA et al., in which goblet cell adenocarcinoma (GCA) is described as a cause of acute appendicitis. Although the article is brilliant in terms of histopathological description of the appendiceal GCA, the surgical indication for right hemicolectomy should be analyzed in depth due to the great controversy that exists in the scientific literature. Read More

J Neuroendocrinol 2022 01 28;34(1):e13076. Epub 2021 Dec 28.

Department of Visceral-, Thoracic- and Vascular Surgery, Philipps-University Marburg, Marburg, Germany.

There are few, but controversial data on the prognostic role of upfront primary tumour resection and mesenteric lymph node dissection (PTR) in patients with diffuse metastatic small intestinal neuroendocrine neoplasia (SI-NEN). Therefore, the prognostic role of PTR and other factors was determined in this setting. This retrospective cohort study included patients with stage IV SI-NETs with unresectable distant metastases without clinical and radiological signs of acute bowel obstruction or ischaemia. Read More

Pol J Radiol 2021 30;86:e644-e653. Epub 2021 Nov 30.

Department of pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: Our purpose is to present our experience in using multidetector computed tomography (MDCT) enterography in the evaluation of localized malignant small intestinal lesions with pathological correlation.

Material And Methods: We retrospectively evaluated 53 patients of pathologically proven malignant localized small intestinal tumours, who underwent multidetector CT enterography.

Results: In this study, the mean age was 51. Read More

BMC Gastroenterol 2021 Dec 13;21(1):464. Epub 2021 Dec 13.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan.

Aim: We aimed to compare the outcomes of different therapeutic modalities in rectal carcinoid tumors.

Method: We retrospectively collected 145 patients with rectal carcinoid tumors which were pathologically diagnosed from 2005/01/01 to 2016/12/31. We compared tumor size, complete resection rate and recurrent rate between different therapeutic modalities. Read More

Can J Urol 2021 12;28(6):10953-10955

Department of Urology, MedStar Washington Hospital Center, Washington, DC, USA.

Acquired hydronephrosis following cystectomy and ileal conduit urinary diversion for bladder cancer is most commonly caused by stricture of the ureter or the ureteroenteric anastomosis. Nevertheless, malignant obstruction due to ureteral tumor recurrence must be ruled out. Neuroendocrine tumors of the ureter are extremely rare and an unlikely cause of hydronephrosis in this setting. Read More

Pathology 2022 Mar 23;54(2):167-176. Epub 2021 Nov 23.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Appendiceal goblet cell adenocarcinomas and mucinous neoplasms are uncommon compared with other epithelial tumours of the gastrointestinal tract. Both tumour types have been subjected to terminology that belies their biological risk and leads to confusion. Goblet cell adenocarcinomas display patchy staining for endocrine markers and, thus, were previously classified as goblet cell carcinoids. Read More

Ann R Coll Surg Engl 2022 Apr 26;104(4):e98-e101. Epub 2021 Nov 26.

Joondalup Health Campus, Australia.

Neuroendocrine neoplasms represent a broad group of uncommon tumours, comprising neuroendocrine tumours, mixed neuroendocrine non-endocrine neoplasms and neuroendocrine carcinomas. While most neuroendocrine neoplasms are well differentiated and exhibit indolent disease biology with excellent treatment response, neuroendocrine carcinomas represent a rare subtype with much more aggressive tumour behaviour, minimal response to adjuvant therapy and extremely poor prognosis. Herein, we report the case of a 47-year-old man who presented with a phlegmonous ascending colonic mass and associated calcified ileocolic lymphadenopathy. Read More

Korean J Gastroenterol 2021 11;78(5):300-304

Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.

Neuroendocrine tumors (NETs) can arise throughout the body. Most NETs in the liver are metastatic tumors; primary hepatic NET (PHNET) is extremely rare. A diagnosis of PHNET is very difficult. Read More

Cancers (Basel) 2021 Oct 30;13(21). Epub 2021 Oct 30.

Service de Chirurgie Digestive, Hôpital Edouard Herriot, Hospices Civils de Lyon, F69437 Lyon, France.

Introduction: Small-intestinal neuroendocrine tumors (siNETs) account for 25% of gastroenteropancreatic NETs. Multiple siNETs appear to develop in a limited segment of the small bowel (SB), 89% of them being located in the ileum, most often within 100 cm of the ileocecal valve (ICV). According to the European Neuroendocrine Tumor Society (ENETS) and the American Joint Committee on Cancer (AJCC), all localized siNETs should be considered for radical surgical resection with adequate lymphadenectomy irrespective of the absence of lymphadenopathy or mesenteric involvement. Read More

Pancreas 2021 09;50(8):e72-e74

ANZ J Surg 2022 04 18;92(4):742-746. Epub 2021 Oct 18.

Department of Pediatric Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Background: Appendiceal neurendocrine tumours (NETs) are rare neoplasms and diagnosis is commonly incidental following appendectomy. We aimed to review our experience with appendiceal NETs.

Methods: Records of children with appendiceal NETs were reviewed and data concerning demographic characteristics, clinical findings, surgical procedures, histopathological findings, management and outcomes were recorded. Read More

Ann Ital Chir 2021 Sep 27;10. Epub 2021 Sep 27.

Goblet cell carcinoid or carcinoma (GCC) refers to an extremely rare appendiceal tumor usually diagnosed on post-operative histology as an incidental finding. Primary cancers of the vermiform appendix are quite rare, representing less than 1% of all gastrointestinal malignancies. GCCs are considered as a distinct entity of appendiceal tumors, consisting of both epithelial (glandular) and neuroendocrine elements containing goblet cells. Read More

Int J Surg Pathol 2022 May 7;30(3):278-281. Epub 2021 Oct 7.

8789University of California Davis, School of Medicine, Sacramento, USA.

Goblet cell adenocarcinoma and signet-ring cell adenocarcinoma are well-known diagnostic pitfalls of routine appendectomy specimens. Here we present a case of acute appendicitis with prominent neuronal (ganglion cell) hyperplasia and swelling which histologically mimics goblet cell adenocarcinoma and signet-ring cell adenocarcinoma. Attention to the cytologic features of the lesional cells (absence of atypia, mitotic activity) and their close association with nerves and classic ganglion cells, along with the use of a limited panel of immunostains, ensures proper classification of this rare but striking benign process. Read More

Medicine (Baltimore) 2021 Oct;100(39):e27389

College of Medicine, QU Health, Qatar University, Doha, Qatar.

Rationale: Peutz-Jeghers syndrome (PJS), a rare autosomal dominant disorder, is characterized by mucocutaneous pigmentations, hamartomatous polyps in the gastrointestinal tract, and a high risk of developing various malignancies. To the best of our knowledge, only 1 case of appendiceal carcinoid associated with PJS has been previously reported in the pediatric population.

Patient Concerns: We report a 7-year-old girl who was admitted for severe, intermittent abdominal pain and cramps, nausea, and vomiting. Read More

Exp Ther Med 2021 Nov 26;22(5):1219. Epub 2021 Aug 26.

Department of Endocrinology, 'I. Hatieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

This is a narrative review focusing on neuroendocrine neoplasia (NEN) and bone status, in terms of metastases and osteoporosis/fractures. One fifth of NEN have skeletal dissemination, this affinity being regulated by intrinsic tumor factors such as the C-X-C chemokine receptor 4 (CXCR4). Bone colonization impairs the patient quality of life, representing a surrogate of reduced survival. Read More

Rev Esp Enferm Dig 2022 Feb;114(2):119-120

Gastroenterology, Hospital General José Agurto Tello, Peru.

Different substances are used for submucosal injection in order to perform a safe endoscopic mucosal resection. Viscous solutions such as sodium hyaluronate are currently considered as the first line substances for submucosal injection. This product produces a durable lifting of the mucosa. Read More

J Dig Dis 2021 Oct;22(10):562-571

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Objective: As there has been so far no consensus on the best endoscopic resection technique, a meta-analysis was conducted to compare the efficacy and safety of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) for treating rectal carcinoid tumors.

Methods: MEDLINE and EMBASE databases were searched for articles on the treatment of rectal carcinoid tumors using ESD vs EMR published up to October 2020 for outcomes including en bloc and complete resection, margin involvement, procedure time, requirement for additional surgery, bleeding, perforation and recurrence. Risk ratio and weighted mean differences were used for a DerSimonian and Laird random effects pairwise meta-analysis. Read More