3,035 results match your criteria Carcinoid Tumor Intestinal


Evaluation of Lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors.

World J Gastroenterol 2020 Apr;26(13):1513-1524

Department of Nuclear Medicine, Santiago de Compostela´s University Hospital, Santiago de Compostela 15706, A Coruña, Spain.

Background: Lu peptide receptor radionuclide therapy (PRRT) is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropancreatic neuroendocrine tumors.

Aim: To determine the impact of PRRT on quality of life, radiologic and metabolic response, overall survival, prognostic factors and toxicity.

Methods: Thirty-six patients treated with Lu-PRRT from 2016 to 2019 were included. Read More

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http://dx.doi.org/10.3748/wjg.v26.i13.1513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152518PMC

[Two Cases of Goblet Cell Carcinoid of Appendix Treated with Oxaliplatin-Based Adjuvant Chemotherapy].

Gan To Kagaku Ryoho 2019 Dec;46(13):2413-2415

Dept. of Gastrointestinal and Pediatric Surgery, Tokyo Medical University.

Although there are reports of goblet cell carcinoid(GCC)treated by chemotherapy using the treatment protocol for colon cancer, the benefit of chemotherapy for GCC remains controversial and unclear. Herein we report 2 cases of patients with GCC who were successfully treated by surgical resection and oxaliplatin-based adjuvant chemotherapy, without evidence of recurrence. The first case was a 57-year-old man who underwent laparoscopic ileocecal resection after being diagnosed with adenocarcinoma of the appendix by biopsy via colonoscopy. Read More

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December 2019

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature.

Chirurgia (Bucur) 2020 Jan-Feb;115(1):102-111

Goblet cell carcinoids (GCC) are extremelyrare neuroendocrine tumours, and characterised by their unique combination of two types of cancer cells âÃÂ" neuroendocrine (carcinoid) and epithelial (adeno-carcinoma). In spite of the fact that GCC is regarded as Neuro-Endocrine Tumour (NET), it does not illicit carcinoid syndrome. GCC usually arises in the appendix and accounting for less than 14% of all appendiceal tumours. Read More

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http://dx.doi.org/10.21614/chirurgia.115.1.102DOI Listing

Somatostatin Analogs in Clinical Practice: a Review.

Int J Mol Sci 2020 Feb 29;21(5). Epub 2020 Feb 29.

Department of Endocrinology, "La Paz" University Hospital. Paseo de la Castellana, 261, 28046 Madrid, Spain.

Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative to corticotropinomas, gonadotropinomas, and prolactinomas resistant to dopamine agonists. Somatostatin analogs have also shown to be useful in the treatment of other endocrine diseases (congenital hyperinsulinism, Graves' orbitopathy, diabetic retinopathy, diabetic macular edema), non-endocrine tumors (breast, colon, prostate, lung, and hepatocellular), and digestive diseases (chronic refractory diarrhea, hepatorenal polycystosis, gastrointestinal hemorrhage, dumping syndrome, and intestinal fistula). Read More

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http://dx.doi.org/10.3390/ijms21051682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084228PMC
February 2020

Appendix Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1226:87-95

Department of Medical and Surgical Sciences, Section of Surgery, University Hospital of Modena, Modena (MO), Italy.

The pathological features of the appendix tumors fundamentally recall those of the more frequent colorectal neoplasms, although with a higher relative incidence of carcinoids, due to the abundant presence of enteroendocrine cells in the appendix wall. Moreover, different types of lymphomas, Hodgkin and non-Hodgkin, arising from the extra-nodal mucosal-associated lymphatic tissue, can be encountered. The appendix tumor microenvironment (TME) consists of a cellular component and of a noncellular component: the former includes the immunocompetent cells, while the latter represents the support stroma. Read More

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http://dx.doi.org/10.1007/978-3-030-36214-0_7DOI Listing
February 2020

Description of a transient proximal tubulopathy induced by amino acids perfusion in peptide receptor radionuclide therapy: A case report.

Medicine (Baltimore) 2019 Dec;98(52):e18478

Department of Nephrology.

Rationale: Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs is a targeted internal radiotherapy method used to treat tumors expressing somatostatin receptors. Concomitant amino acids perfusion is systematically performed in order to inhibit the proximal tubular uptake of the radionuclide and thus prevent nephrotoxicity. PATIENT CONCERNS:: a 67-year-old woman with an intestinal neuroendocrine tumor with multiple lymphadenopathies and liver metastases. Read More

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http://dx.doi.org/10.1097/MD.0000000000018478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946443PMC
December 2019

New and emerging systemic therapy options for well-differentiated gastroenteropancreatic neuroendocrine tumors.

Expert Opin Pharmacother 2020 Feb 24;21(2):183-191. Epub 2019 Nov 24.

Department of Surgery, Division of Surgical Oncology at The Ohio State University, James Cancer Center, Columbus, OH, USA.

: Well-differentiated gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with a wide range of clinical behavior. Multiple treatment modalities exist, including novel and emerging systemic options, and an understanding of the advantages and disadvantages of each is imperative for optimizing the outcomes of patients with GEP-NETs.: While surgical resection remains the preferred treatment for localized well-differentiated GEP-NETs, treatment of unresectable disease depends on its extent, location, and distribution as well as underlying aspects of tumor biology. Read More

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http://dx.doi.org/10.1080/14656566.2019.1694003DOI Listing
February 2020

Clinical characteristics of appendiceal diverticular disease.

Int J Colorectal Dis 2019 Dec 4;34(12):2035-2041. Epub 2019 Nov 4.

Department of Anaesthesiology, Health Sciences University Turkish Ministry of Health İstanbul Research and Training Hospital, İstanbul, Turkey.

Background: Appendiceal diverticular disease (ADD) is a rare pathology which is associated with an increased mortality risk due to rapid perforation and high rates of neoplasm. In our study, we aimed to evaluate the clinical and histopathological characteristics of ADD with differences from acute appendicitis (AA) diagnosis and to determine the association with neoformative processes.

Methods: The 4279 patients who underwent appendectomy were evaluated retrospectively. Read More

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http://dx.doi.org/10.1007/s00384-019-03410-2DOI Listing
December 2019
1 Read

Survival trends of metastatic small intestinal neuroendocrine tumor: a population-based analysis of SEER database.

J Gastrointest Oncol 2019 Oct;10(5):869-877

Department of Medicine, Western Michigan University School of Medicine, Kalamazoo, MI, USA.

Background: Incidence of small intestinal neuroendocrine tumors (SNETs) is increasing and they now comprise the most common types of small intestinal cancer. SNETs frequently present with distant metastasis. Significant uncertainty prevails with regards to the surgical management strategies in metastatic SNETs. Read More

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http://dx.doi.org/10.21037/jgo.2019.05.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776814PMC
October 2019
1 Read

[Current standards and novel developments in the treatment of neuroendocrine tumors of the gastroenteropancreatic system].

Dtsch Med Wochenschr 2019 10 8;144(20):1390-1395. Epub 2019 Oct 8.

Klinik und Poliklinik für Nuklearmedizin, Klinikum der Universität München, Ludwig-Maximilians-Universität, München.

Current guidelines have been published for the diagnosis and therapy of neuroendocrine neoplasms of the gastroenteropancreatic (GEP) system 1. Systemic therapy of inoperable advanced neuroendocrine tumors includes biotherapy with somatostatin analogas, peptid receptor radionuclide therapy (PRRT) with 177Lutetium-DOTA-TATE, chemotherapy with steptozotocin/5-fluorouracil or capecitabine/temozolomide and molecular targeted therapy with everolimus or sunitinib 1 2. For symptom control in patients with carcinoid syndrome biotherapy with somatostatin analogs, PRRT, loco-regional and local-ablative interventional procedures of liver metastases as well as the peripheral serotonin synthesis inhibitor telotristat Ethyl 1 2 3 4 are highly effective. Read More

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http://dx.doi.org/10.1055/a-0801-3686DOI Listing
October 2019
3 Reads

Primary small intestinal neuroendocrine tumors are highly prevalent and often multiple before metastatic disease develops.

Scand J Surg 2019 Oct 7:1457496919874484. Epub 2019 Oct 7.

Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden.

Background: Small intestinal neuroendocrine tumors are the most common of small bowel malignancies with a clinical incidence of about 1 per 100,000 persons per year. There has been a threefold increase in the incidence of small intestinal neuroendocrine tumor during later decades, but there are no studies that clarify whether this is due to a true higher incidence or if the rise is a mere product of, for instance, improved diagnostic modalities. The aim of this study was to investigate the incidence of clinical as well as subclinical small intestinal neuroendocrine tumors found at autopsy as well as describing the frequency of concomitant malignancies in patients with small intestinal neuroendocrine tumor. Read More

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http://dx.doi.org/10.1177/1457496919874484DOI Listing
October 2019
1 Read

[Pulmonary carcinoids and carcinoids of the small intestine].

Radiologe 2019 Nov;59(11):968-974

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, LMU München, Marchioninistraße 15, 81377, München, Deutschland.

Clinical/methodical Issue: Pulmonary carcinoids and carcinoids of the small intestine (jejunum and ileum) are often asymptomatic and can affect various parts of the body, which makes diagnosis difficult.

Standard Radiological Methods: Contrast-enhanced computed tomography (CE-CT) is commonly used for primary diagnostics. In case of concomitant pulmonary consolidation (e. Read More

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http://dx.doi.org/10.1007/s00117-019-00597-xDOI Listing
November 2019
2 Reads

[Clinicopathological features and prognosis of 488 patients with neuroendocrine tumors].

Zhonghua Yi Xue Za Zhi 2019 Aug;99(32):2527-2531

Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathological features and prognosis of patients with neuroendocrine tumors (NETs). The clinicopathologic data of enrolled patients with NETs between October 2012 and October 2017 at the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. Among the 488 NETs patients, the average age was (51. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.32.012DOI Listing
August 2019
2 Reads

Carcinoid tumors of appendix presenting as acute appendicitis.

Ulus Travma Acil Cerrahi Derg 2019 Aug;25(5):510-513

Department of General Surgery, İnönü University Faculty of Medicine, Malatya-Turkey.

Background: We aim to present the data of patients who underwent appendectomy due to acute appendicitis, and incidental carcinoid tumor was detected on pathology.

Methods: Retrospective analysis of the patient charts between January 1999 and September 2018 were performed.

Results: 2778 appendectomy was performed due to acute appendicitis. Read More

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http://dx.doi.org/10.5505/tjtes.2018.99569DOI Listing
August 2019
1 Read

The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs.

Dig Liver Dis 2019 12 9;51(12):1725-1730. Epub 2019 Aug 9.

University Denis Diderot - Paris VII, Paris, France; Department of Gastroenterology and Pancreatology, Beaujon Hospital, APHP, ENETs Center of Excellence, Clichy, France.

Background: Factors associated with rectal NENs prognosis are poorly investigated.

Aim: To evaluate the prognostic role of the ENETs staging and grading systems in rectal NENs.

Methods: Tertiary referral, multicenter, retrospective study. Read More

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http://dx.doi.org/10.1016/j.dld.2019.07.011DOI Listing
December 2019
1 Read

Incidence of composite intestinal adenoma-microcarcinoid in 158 surgically resected polyps and its association with squamous morule.

Ann Diagn Pathol 2019 Oct 15;42:69-74. Epub 2019 Jul 15.

Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, USA. Electronic address:

Composite intestinal adenoma-microcarcinoid (CIAM) is a rare colorectal lesion consisting of adenoma and small well-differentiated neuroendocrine cell clusters at its base. Its incidence is unknown. Benign squamous morule may demonstrate a neuroendocrine phenotype by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.07.004DOI Listing
October 2019
3 Reads

A case of feline primary duodenal carcinoid with intestinal hemorrhage.

J Vet Med Sci 2019 Aug 28;81(8):1086-1089. Epub 2019 Jun 28.

Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.

A 15-year-old neutered male Persian cat was presented with recurrent hematemesis and melena. Abdominal ultrasonography and computed tomography revealed a mass in the proximal descending duodenal wall. Endoscopic examination revealed hemorrhage on the luminal side of the mass. Read More

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http://dx.doi.org/10.1292/jvms.19-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715922PMC
August 2019
4 Reads

Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.

Int J Mol Sci 2019 Jun 22;20(12). Epub 2019 Jun 22.

Charité, Campus Virchow Klinikum and Charité, Campus Mitte, Department of Hepatology and Gastroenterology, Universitätsmedizin Berlin, 10117 Berlin, Germany.

In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no longer available. Prognosis and survival of patients with NETs are determined by the location of the primary lesion, biochemical functional status, differentiation, initial staging, and response to treatment. Read More

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http://dx.doi.org/10.3390/ijms20123049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627451PMC
June 2019
6 Reads

Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study.

Anticancer Res 2019 May;39(5):2513-2517

Clinic of Obstetrics and Gynecology, San Gerardo Hospital, Monza, Department of Medicine and Surgery, University of Milan Bicocca, Milan, Italy.

Background/aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma.

Patients And Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39. Read More

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http://dx.doi.org/10.21873/anticanres.13372DOI Listing
May 2019
17 Reads

Perianal Goblet Cell Carcinoid With Pagetoid Spread.

Int J Surg Pathol 2019 Oct 13;27(7):788-791. Epub 2019 May 13.

1 Icahn School of Medicine at Mount Sinai, New York, NY, USA.

We present a case of perianal goblet cell carcinoid with pagetoid spread. Goblet cell carcinoid, also known as adenocarcinoid tumor, predominantly arises as a primary appendiceal tumor and contains nests of neuroendocrine and mucin-containing cells. When this tumor type is seen in other sites it usually represents a metastasis. Read More

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http://dx.doi.org/10.1177/1066896919845478DOI Listing
October 2019
2 Reads

Dual-phase computed tomography angiography of intestinal carcinoid tumor as a lead point for cecocolic intussusception in a dog.

J Vet Med Sci 2019 Jun 17;81(6):928-932. Epub 2019 Apr 17.

College of Veterinary Medicine and BK 21 Plus Project Team, Chonnam National University, Gwangju 61186, South Korea.

In an 8-year-old Labrador Retriever with progressive anorexia, constipation, and depression, CT revealed intussusception of the cecum into the ascending colon and a small cecal mass showing strong enhancement on arterial phase. The ileocecocolic junction was surgically resected and histologically diagnosed as cecocolic intussusception with carcinoid tumor. The carcinoid tumor worked as a lead point of intussusception in this case. Read More

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http://dx.doi.org/10.1292/jvms.19-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612499PMC
June 2019
8 Reads

Osteoporosis Circumscripta on 68Ga-DOTATATE PET CT.

Clin Nucl Med 2019 Jun;44(6):e404-e405

From the Nuclear Medicine Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.

Incidental findings on PET CT studies are common. The distribution of Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis circumscripta is the early lytic phase of Paget disease associated with well-defined osteopenia, most commonly seen within the skull on imaging. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002567DOI Listing
June 2019
23 Reads

Endoloop ligation after endoscopic mucosal resection using a transparent cap: A novel method to treat small rectal carcinoid tumors.

World J Gastroenterol 2019 Mar;25(10):1259-1265

Department of Gastroenterology, Shenzhen People's Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China.

Background: Local endoscopic resection is an effective method for the treatment of small rectal carcinoid tumors, but remnant tumor at the margin after resection remains to be an issue.

Aim: To evaluate the efficacy and safety of resection of small rectal carcinoid tumors by endoloop ligation after cap-endoscopic mucosal resection (LC-EMR) using a transparent cap.

Methods: Thirty-four patients with rectal carcinoid tumors of less than 10 mm in diameter were treated by LC-EMR ( = 22) or endoscopic submucosal dissection (ESD) ( = 12) between January 2016 and December 2017. Read More

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http://dx.doi.org/10.3748/wjg.v25.i10.1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421235PMC
March 2019
8 Reads

Vitamin D and vitamin B deficiencies in patients with small intestinal carcinoid tumour: is opioid use disorder a confounding factor in the diagnosis?

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Allama Iqbal Medical College, Lahore, Pakistan.

Carcinoid tumours have the ability to secrete various peptides and bioamines that lead to carcinoid syndrome manifested as cutaneous flushing, diarrhoea, bronchial constriction and cardiac involvement. The deficiencies of vitamins D and B have previously been reported in patients with carcinoid tumours presumably due to chronic diarrhoea associated with the carcinoid syndrome. Herein, we chronicle the case of a patient with opioid use disorder who presented with small bowel obstruction that was found to be caused by a midgut carcinoid tumour. Read More

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http://dx.doi.org/10.1136/bcr-2018-227430DOI Listing
March 2019
14 Reads

When right heart valves are open 24/7.

Turk Kardiyol Dern Ars 2019 03;47(2):156

Department of Cardiology, King's College Hospital, London, United Kingdom.

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http://dx.doi.org/10.5543/tkda.2018.01940DOI Listing
March 2019
3 Reads

Minimally Invasive Small Bowel Cancer Surgery.

Surg Oncol Clin N Am 2019 04 24;28(2):273-283. Epub 2018 Dec 24.

Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305, USA. Electronic address:

Small bowel malignancies are extremely rare. Surgical resection is often the mainstay of treatment with the extent of the operation depending on the type of tumor. Whereas neuroendocrine tumors and adenocarcinoma require lymph node resection, gastrointestinal stromal tumors do not typically metastasize to regional nodes and therefore need resection only. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.008DOI Listing
April 2019
6 Reads

Bowel Imaging in Children: Part 2.

Indian J Pediatr 2019 09 21;86(9):817-829. Epub 2019 Feb 21.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, 110029, India.

The bowel is a challenging abdominal organ to image. A variety of bowel disorders such as congenital, developmental, inflammatory, infectious and neoplastic lesions can affect children and most of them are either unique to this age group or have a distinct clinico-radiological appearance compared to adults. Imaging forms an integral part of management of these disorders. Read More

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http://dx.doi.org/10.1007/s12098-019-02878-8DOI Listing
September 2019
16 Reads

Knowledge gaps in the appendix: a multi-institutional study from seven academic centers.

Mod Pathol 2019 07 14;32(7):988-996. Epub 2019 Feb 14.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Appendix pathology represents uncommonly encountered specimens with unique diagnostic challenges. To delineate common knowledge gaps, extramural consults submitted to seven institutions between 2016-2017 were reviewed. All appendix consults were resections (100%, n = 43), and the majority were directed for consultation by the originating pathologist (95%, n = 41) with no additional studies performed by the consultant (65%, n = 28). Read More

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http://dx.doi.org/10.1038/s41379-019-0216-xDOI Listing
July 2019
24 Reads

Multifocal Small Bowel Carcinoid: Evaluation by 68Ga-DOTATATE PET.

Clin Nucl Med 2019 04;44(4):e308-e310

From the Department of Radiology, Division of Nuclear Medicine, Mayo Clinic, Rochester, MN.

Carcinoid is a subtype of neuroendocrine tumor, a rare group of tumors that are known to express somatostatin receptor 2. Ga-DOTATATE is a somatostatin analog that is specific for somatostatin receptor 2 and therefore allows visualization of neuroendocrine tumors. We present 2 cases of primary multifocal small bowel carcinoid evaluated using Ga-DOTATATE PET/CT, along with contrast-enhanced CT corollary findings. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002487DOI Listing
April 2019
7 Reads

Cardiac Metastases of Small-Bowel Carcinoid.

Circ Cardiovasc Imaging 2019 02;12(2):e008405

Biophysics and Nuclear Medicine (S.E.G., C.B., A.I.), University Hospitals of Strasbourg, University of Strasbourg, France.

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008405DOI Listing
February 2019
1 Read

Medical Management of Gastroenteropancreatic Neuroendocrine Tumors: Current Strategies and Future Advances.

J Nucl Med 2019 Jun 8;60(6):721-727. Epub 2019 Feb 8.

H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida

Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms, characterized by a propensity to secrete hormones that cause distinct clinical syndromes. During the past decade, the systemic treatment landscape has improved significantly: new options include everolimus, an inhibitor of the mammalian target of rapamycin; sunitinib, an angiogenesis inhibitor; and cytotoxic regimens such as capecitabine and temozolomide. Moreover, the recent approval of the radiolabeled somatostatin analog Lu-DOTATATE has had a significant impact on management of neuroendocrine malignancies. Read More

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http://dx.doi.org/10.2967/jnumed.118.214882DOI Listing
June 2019
4 Reads

Serotonin levels and 1-year mortality in patients with neuroendocrine tumors: a systematic review and meta-analysis.

Future Oncol 2019 Apr 8;15(12):1397-1406. Epub 2019 Feb 8.

Icahn School of Medicine, Center for Carcinoid and Neuroendocrine Tumors, Mount Sinai Health System, New York, NY 10029, USA.

Elevated serotonin in patients with neuroendocrine tumors (NETs) may impact heart failure incidence but a quantitative relationship has not been established. Systematic review and meta-analysis of studies assessing 24-h urinary 5-hydroxyindoleacetic acid (u5-HIAA) and mortality in patients with NETs (2007-2017) with a primary outcome of 1-year mortality risk and 24-h u5-HIAA. We identified 1715 records of which 12 studies including 755 patients (3442 person-years with 376 deaths) were eligible for meta-analysis. Read More

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https://www.futuremedicine.com/doi/10.2217/fon-2018-0960
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http://dx.doi.org/10.2217/fon-2018-0960DOI Listing
April 2019
3 Reads

Incomplete cold snare polypectomy for rectal carcinoid tumour.

Arab J Gastroenterol 2019 Mar 4;20(1):59-60. Epub 2019 Feb 4.

Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan; Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ajg.2018.12.002DOI Listing
March 2019
2 Reads

Rare case of small intestine bleeding.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Medicine, Section of Digestive Diseases, West Virginia University Hospitals, Morgantown, West Virginia, USA.

We present a case of a healthy 59-year-old woman who presented for a capsule endoscopy to evaluate melaena and iron deficiency anaemia. She had previously underwent an oesophagogastroduodenoscopy and colonoscopy at an outside institution which were unremarkable. Capsule endoscopy showed an ulcerated, bleeding lesion likely in the duodenum. Read More

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http://dx.doi.org/10.1136/bcr-2018-227184DOI Listing
January 2019
5 Reads

Cost-of-illness of metastatic gastroenteropancreatic neuroendocrine tumours in Sweden-A population-based register-linkage study.

Eur J Cancer Care (Engl) 2019 Mar 16;28(2):e12983. Epub 2019 Jan 16.

Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

The objective was to estimate the cost-of-illness of grades 1 and 2 metastatic gastroenteropancreatic neuroendocrine tumours (GEP-NETs) in Sweden in 2013 in a population-based study including all patients diagnosed between 2005 and 2013. Data were obtained from national registers, and patients who utilised healthcare resources due to metastatic GEP-NETs in 2013 were included. The study included 478 patients (mean age 64 [SD=11] years, 51% men). Read More

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http://dx.doi.org/10.1111/ecc.12983DOI Listing
March 2019
4 Reads
1.762 Impact Factor

Goblet Cell Carcinoid/Carcinoma: An Update.

Adv Anat Pathol 2019 Mar;26(2):75-83

Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA.

Goblet cell carcinoid (GCC) or goblet cell carcinoma is a unique mixed endocrine-exocrine neoplasm that is almost exclusively seen in the appendix. The hallmark of GCC is the concentric infiltration of the appendiceal wall by small tight clusters, nests or cords of tumor cells that exhibit a goblet cell morphology with a small compressed nucleus and conspicuous intracytoplasmic mucin. The coexistence of high-grade adenocarcinoma with GCC has been increasingly recognized as a common finding, which has been called adenocarcinoma ex GCC or mixed GCC-adenocarcinoma. Read More

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http://Insights.ovid.com/crossref?an=00125480-900000000-9992
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http://dx.doi.org/10.1097/PAP.0000000000000222DOI Listing
March 2019
19 Reads

Multiple neuroendocrine tumor of the small bowel: a case report and a review of literature.

Vnitr Lek Fall 2018;64(10):966-969

Primary malignant tumors of small bowel constitute only about 1-2% of all gastrointestinal neoplasms. Although neuroendocrine tumors (NETs) are relatively rare, they still represent the second most common malignancy of the small bowel (after adenocarcinoma). Clinical manifestations include abdominal pain, bowel obstruction, diarrhea, weight loss and bleeding. Read More

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May 2019
36 Reads

The safety of lanreotide for neuroendocrine tumor.

Expert Opin Drug Saf 2019 Jan 24;18(1):1-10. Epub 2018 Dec 24.

a Gastrointestinal Oncology Program and Experimental therapeutics, Division of Hematology/Oncology , Tufts Medical Center - Tufts University School of Medicine , Boston , MA , USA.

Introduction: Lanreotide autogel is a synthetic somatostatin analogue which has been FDA and EMA approved for unresectable, well to moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumor. Its action is mediated by its affinity to somatostatin receptors, especially sst2 and sst5 receptors. Its longer half-life offers the convenience of 4-week dosing over the need for frequent injections of short-acting somatostatin analogues. Read More

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https://www.tandfonline.com/doi/full/10.1080/14740338.2019.1
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http://dx.doi.org/10.1080/14740338.2019.1559294DOI Listing
January 2019
7 Reads
2.911 Impact Factor

Prevalence of Small Intestine Carcinoid Tumors: A US Population-Based Study 2012-2017.

Dig Dis Sci 2019 05 5;64(5):1328-1334. Epub 2018 Dec 5.

Division of Gastroenterology and Liver Disease, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Wearn 244, Cleveland, OH, 44106, USA.

Background And Aims: Most carcinoid tumors of the gastrointestinal tract are located in the small bowel (SB). Epidemiological studies of these tumors have been limited by small sample sizes. Our aim was to evaluate the epidemiology of SB carcinoids (SBCs) using a large database. Read More

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http://dx.doi.org/10.1007/s10620-018-5402-zDOI Listing
May 2019
5 Reads

[Imaging characteristics of gastrointestinal neoplastic acute abdomen].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1223-1229

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Read More

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November 2018
8 Reads

ASO Author Reflections: Outcomes of Appendiceal Goblet Cell Carcinoid Tumors.

Ann Surg Oncol 2018 12 21;25(Suppl 3):759-760. Epub 2018 Nov 21.

Virginia Mason Hospital and Seattle Medical Center, Virginia Mason Cancer Institute, Seattle, WA, USA.

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http://dx.doi.org/10.1245/s10434-018-6980-xDOI Listing
December 2018
3 Reads

Endoscopic Resection of Duodenal Carcinoid Tumors: A Single-Center Comparison Between Simple Polypectomy and Endoscopic Mucosal Resection.

Pancreas 2019 01;48(1):60-65

Department of Medicine, Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA.

Objectives: Endoscopic resection is preferred for duodenal carcinoids less than 20 mm; however, the efficacy of simple polypectomy has not been compared with advanced endoscopic resection techniques.

Methods: We performed a retrospective review of 33 patients who underwent endoscopic duodenal carcinoid resection (10 simple, 23 endoscopic mucosal resection) at the Hospital of the University of Pennsylvania between January 1, 2006, and June 15, 2017. The primary outcomes were resection margin positivity and local tumor recurrence. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289751PMC
January 2019
35 Reads

Robotic Transanal Minimally Invasive Surgery for the Excision of Rectal Neoplasia: Clinical Experience With 58 Consecutive Patients.

Dis Colon Rectum 2019 03;62(3):279-285

Kaiser Permanente, Department of General Surgery, San Diego, California.

Background: Given the significant perioperative risks and costs of total mesorectal excision, minimally invasive transanal surgical approaches have grown in popularity for early rectal cancer and rectal polyps. This article discusses a transanal robotic surgery technique to perform full-thickness resections of benign and malignant rectal neoplasms.

Objective: The purpose of this study was to describe an initial experience with robotic transanal minimally invasive surgery. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001223DOI Listing
March 2019
30 Reads

Real-world treatment patterns, resource use and costs of treating uncontrolled carcinoid syndrome and carcinoid heart disease: a retrospective Swedish study.

Scand J Gastroenterol 2018 Dec 19;53(12):1509-1518. Epub 2018 Nov 19.

e Department of Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden.

Objectives: To quantify healthcare resource use (HRU) and costs in relation to carcinoid syndrome (CS) and carcinoid heart disease (CHD) in a real-world setting, and to provide perspective on treatment patterns.

Materials And Methods: Patient data and HRU were collected retrospectively from three Swedish healthcare registers. Adult patients diagnosed with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) grade 1 or 2 and CS who purchased somatostatin analogs (SSAs), and experienced controlled (defined by SSAs use) and uncontrolled (defined by SSAs dose escalation) CS for ≥8 months during the study period were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1
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http://dx.doi.org/10.1080/00365521.2018.1531653DOI Listing
December 2018
41 Reads
2.329 Impact Factor

A prospective study of the pathophysiology of carcinoid crisis.

Surgery 2019 01 8;165(1):158-165. Epub 2018 Nov 8.

Division of Surgical Oncology, Oregon Health & Science University, Portland. Electronic address:

Background: Sudden massive release of serotonin, histamine, kallikrein, and bradykinin is postulated to cause an intraoperative carcinoid crisis. The exact roles of each of these possible agents, however, remain unknown. Optimal treatment will require an improved understanding of the pathophysiology of the carcinoid crisis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183062
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http://dx.doi.org/10.1016/j.surg.2018.04.093DOI Listing
January 2019
43 Reads

Analysis of the immune landscape of small bowel neuroendocrine tumors.

Endocr Relat Cancer 2019 01;26(1):119-130

Department of GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Immune checkpoint inhibitors have shown promising results in different cancers, and correlation between immune infiltration, expression of programmed death-ligand 1 (PD-L1) by tumor cells and response to immunotherapy has been reported. There is limited knowledge regarding the immune microenvironment of small bowel (SB) neuroendocrine tumors (NETs). This work was aimed at characterizing the immune landscape of SB NETs. Read More

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https://erc.bioscientifica.com/view/journals/erc/26/1/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0189DOI Listing
January 2019
22 Reads

Influence of carcinoid syndrome on the clinical characteristics and outcomes of patients with gastroenteropancreatic neuroendocrine tumors undergoing operative resection.

Surgery 2019 03 28;165(3):657-663. Epub 2018 Oct 28.

Division of Surgical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH. Electronic address:

Background: The incidence, clinical characteristics, and long-term outcomes of patients with gastroenteropancreatic neuroendrocrine tumors and carcinoid syndrome undergoing operative resection have not been well characterized.

Methods: Patients undergoing resection of primary or metastatic gastroenteropancreatic neuroendrocrine tumors between 2000 and 2016 were identified from an 8-institution collaborative database. Clinicopathologic and postoperative characteristics as well as overall survival and disease-free survival were compared among patients with and without carcinoid syndrome. Read More

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http://dx.doi.org/10.1016/j.surg.2018.09.008DOI Listing
March 2019
22 Reads

Distinct Imaging Characteristics of Different Metastases From Primary Prostate Adenocarcinoma and Rectal Carcinoid Tumor on 18F-Fluciclovine and 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Jan;44(1):83-84

Department of Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9740
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http://dx.doi.org/10.1097/RLU.0000000000002358DOI Listing
January 2019
32 Reads

Resection of primary tumor may prolong survival in metastatic gastroenteropancreatic neuroendocrine tumors.

Surgery 2019 03 23;165(3):644-651. Epub 2018 Oct 23.

Rush University Medical Center, Department of Surgery, Chicago IL. Electronic address:

Background: Patients with gastroenteropancreatic neuroendocrine tumors often present with stage IV disease. Primary tumor resection in these patients remains controversial. Herein, we studied the impact of primary tumor removal, identified variables associated with prolonged survival for each neuroendocrine tumor subtype, and determined factors that influence surgeons to perform primary tumor resection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183065
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http://dx.doi.org/10.1016/j.surg.2018.09.006DOI Listing
March 2019
34 Reads

Report of metastatic ileal neuroendocrine tumor to the submandibular gland.

Int J Surg Case Rep 2018 19;53:1-4. Epub 2018 Oct 19.

Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Neuroendocrine tumors (NETs) of small intestinal origin are generally slow-growing tumors with a relatively high propensity for metastases to surrounding organs and lymphatic tissue. We present the first case of an ileal NET metastasizing to the submandibular gland in a woman with metastatic carcinoid syndrome.

Case Presentation: A 55-year-old female presented with a four-month history of a palpable, left-sided neck mass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183045
Publisher Site
http://dx.doi.org/10.1016/j.ijscr.2018.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203236PMC
October 2018
17 Reads