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Expert Rev Endocrinol Metab 2010 Nov;5(6):855-866

c Department of Diagnostic Radiology, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany.

Endocrine pancreatic tumors, also known as pancreatic islet tumors, are rare entities of neuroendocrine origin that are located within the pancreas or in its close proximity. Approximately 50% of these tumors secrete biologically active substances that lead to the development of specific clinical syndromes. Once diagnosis has been established on the basis of clinical and laboratory findings, localization of the source of pathologic hormone secretion is warranted. Read More

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

Kyobu Geka 2019 Feb;72(2):160-163

Department of Thoracic Surgery, Shinkoga Hospital, Kurume, Japan.

A 45-year-old woman, who had been treated for bronchial asthma, was referred to our hospital with symptoms of dyspnea. Upon examination, we found the right main bronchus to be almost completely occluded by an endobronchial tumor. For the purpose of diagnosis and relieving the dyspnea, we performed a rigid bronchoscopic tumor resection with a high frequency snare. Read More

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Department of Radiology, Division of Nuclear Medicine, Mayo Clinic, Rochester, MN.

Carcinoid is a subtype of neuroendocrine tumor, a rare group of tumors that are known to express somatostatin receptor 2. Ga-DOTATATE is a somatostatin analog that is specific for somatostatin receptor 2 and therefore allows visualization of neuroendocrine tumors. We present 2 cases of primary multifocal small bowel carcinoid evaluated using Ga-DOTATATE PET/CT, along with contrast-enhanced CT corollary findings. Read More

Eur J Cardiothorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA.

Objectives: The aim of this study is to evaluate the efficacy of chest computed tomography (CT) to predict the pathological stage of thymic epithelial tumours (TET) using the recently introduced tumour, node and metastasis (TNM) staging with comparison to the modified Masaoka staging.

Methods: Preoperative chest CT examinations in cases of resected TET with sampled lymph nodes (2006-2016) were retrospectively reviewed by 2 thoracic radiologists and radiologically (r) staged using both staging systems. A thoracic pathologist reviewed all cases for the pathological (p) stage. Read More

SAGE Open Med Case Rep 2019 1;7:2050313X19827749. Epub 2019 Feb 1.

Department of Thoracic and Cardiovascular Surgery, Osaka Medical College Hospital, Takatsuki, Japan.

Thymomas are tumors originating from the thymus epithelial cells and are the most common tumors of the anterior mediastinum. They have been classified into types A, AB, B1, B2, and B3 by the World Health Organization. Type B3 thymoma is composed of epithelial cell sheets with mild to moderate atypia and scant lymphocytes. Read More

Ann Endocrinol (Paris) 2019 Jan 29. Epub 2019 Jan 29.

Endocrinology, Clinique Saint Luc de Bouge, UCL, 8, rue Saint-Luc, 5004 Bouge, Belgium. Electronic address:

Arab J Gastroenterol 2019 Feb 4. Epub 2019 Feb 4.

Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan; Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan. Electronic address:

Diagn Pathol 2019 Feb 7;14(1):12. Epub 2019 Feb 7.

Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Primary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical carcinoid are extremely rare, and little is known about parameters that may predict prognosis at diagnosis.

Methods: Six cases of primary renal WDNET were collected. After reviewing slides stained with hematoxylin and eosin, proportions of each growth pattern were determined. Read More

Oncotarget 2019 Jan 1;10(1):17-29. Epub 2019 Jan 1.

Department of Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Background: Neuroendocrine carcinomas of the prostate (NEPCs) are rare tumors with poor prognosis. While platinum and etoposide-based chemotherapy regimens (PE) are commonly applied in first-line for advanced disease, evidence for second-line therapy and beyond is very limited.

Methods: Retrospective analysis of all patients with NEPCs including mixed differentiation with adenocarcinoma component and well differentiated neuroendocrine tumors (NETs, carcinoids) at two high-volume oncological centers between 12/2000 and 11/2017. Read More

J Gastrointest Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Surgical Oncology, Harold C. Simmons Cancer Center, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-8548, USA.

Background: Meckel's diverticulum (MD) is an anomaly of the small intestine from which malignancy may arise. Among MD neoplasms, neuroendocrine tumors (NETs) are considered the most common. However, their metastatic potential and optimal surgical therapy remain ill-defined. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14315

Department of Pathology, the First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang.

Rationale: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm.

Patient Concerns: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Medicine, Section of Digestive Diseases, West Virginia University Hospitals, Morgantown, West Virginia, USA.

We present a case of a healthy 59-year-old woman who presented for a capsule endoscopy to evaluate melaena and iron deficiency anaemia. She had previously underwent an oesophagogastroduodenoscopy and colonoscopy at an outside institution which were unremarkable. Capsule endoscopy showed an ulcerated, bleeding lesion likely in the duodenum. Read More

Iran J Pathol 2018 17;13(2):196-204. Epub 2018 Jul 17.

Registrar Pathology, Apollo Hospitals, Bangalore, Bangalore, India.

Background & Objective: Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma.The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC).

Methods: Consecutive pleural biopsy specimens positive for a neoplasm, both primary and metastatic, were included in the study. Read More

Nucl Med Commun 2019 Jan 28. Epub 2019 Jan 28.

Department of Nuclear Medicine, Diyarbakir Gazi Yasargil Training and Research Hospital.

Objective: This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors.

Materials And Methods: A total of 20 patients [mean (SD) age: 52.2 (12. Read More

Am J Surg 2018 Dec 28. Epub 2018 Dec 28.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA. Electronic address:

Background: Gastric carcinoids are rare neuroendocrine tumors of the gastrointestinal tract. They are typically managed according to their etiology. However, there is little known about the impact of surgical strategy on the long-term outcomes of these patients. Read More

Asian Pac J Cancer Prev 2019 Jan 25;20(1):53-57. Epub 2019 Jan 25.

Radiotherapy Development Department in Provincial Multidisciplinary Hospital in Gorzów Wielkopolski, ul Dekerta 1, 66-400 Gorzow Wielkopolski LLC, Poland.

Purpose: This study aimed to evaluate the impact of tumor volume on platelet counts (PLT) and mean platelet volume (MPV) and involve these parameters on overall survival. Methods: It is a retrospective study of 99 patients with lung cancer (confirmed histologically or cytologically). Sixty-six patients underwent radical operating treatment and 33 patients had only biopsies – due to the inoperable status of tumor According to the histopathology profile: non-small cell carcinoma – 23%, adenocarcinoma - 23 %, squamous - 36%, small cell carcinoma -11%, carcinoid – 6%. Read More

J Gastrointest Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.

Introduction: Patients with midgut neuroendocrine tumors (MNETs) frequently present with metastatic disease at the time of diagnosis. Although combined resection of the primary MNET and liver metastases (NELM) is usually recommended for appropriate surgical candidates, primary tumor resection (PTR) in the setting of extensive, inoperable metastatic disease remains controversial.

Methods: A systematic review was performed according to PRISMA guidelines utilizing Medline (PubMed), Embase, and Cochrane library-Cochrane Central Register of Controlled Trials (CENTRAL) databases until September 30, 2018. Read More

J Clin Endocrinol Metab 2019 Jan 16. Epub 2019 Jan 16.

Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Pulmonary carcinoids (PC) belong to neuroendocrine tumors that often overexpress somatostatin receptors (SSTR). This overexpression provides a molecular basis for tumor imaging and treatment with somatostatin analogs.

Objective: To evaluate SSTR1-5 distribution in a large set of PC tumors and to investigate whether the expression is associated with clinicopathological and outcome data. Read More

Oncologist 2019 Jan 16. Epub 2019 Jan 16.

Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

Background: Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience considerable morbidity and mortality; carcinoid syndrome may be associated with shorter survival. Carcinoid syndrome is linked to tumoral secretion of serotonin and other bioactive substances. The subsequent debilitating diarrhea and urgency to defecate pose significant health risks. Read More

Am J Surg 2019 Jan 3. Epub 2019 Jan 3.

Division of Surgical Oncology, Oregon Health & Science University, United States. Electronic address:

Background: Patients with carcinoid tumors are at risk for profound intraoperative hypotension known as carcinoid crisis, which catecholamines are traditionally believed to trigger. However, data supporting this are lacking.

Methods: Anesthesia records were retrospectively reviewed for carcinoid patients treated with vasopressors. Read More

Case Rep Urol 2018 3;2018:3614387. Epub 2018 Dec 3.

University of Balamand, Saint George Hospital University Medical Center, Department of Urology, Beirut 1100 2807, Lebanon.

Carcinoid tumors usually arise in the gastrointestinal tract. Immunocytohistochemical and radiologic studies are important in detecting the primary tumor site. Primary carcinoid tumors of the testis are particularly rare with a high malignant potential warranting long-term follow-up. Read More

Cardiovasc Intervent Radiol 2019 Jan 9. Epub 2019 Jan 9.

Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY, 10065, USA.

Purpose: To evaluate initial response and overall survival of neuroendocrine tumor (NET) liver metastases initially treated with transarterial embolization (TAE) using spherical particles of different sizes.

Methods: A single-institution retrospective review was performed of 160 patients with NET liver metastases initially treated with TAE using < 100 µm (n = 77) or only ≥ 100 µm (n = 83) spherical particles. For each patient, we evaluated: initial response by mRECIST, time to progression, overall survival, complications, primary site, tumor grade and degree of differentiation, volume of liver disease, extrahepatic disease, NET-related symptoms, comorbidities, Child-Pugh score, performance status, lobar versus selective embolization, and arteriovenous shunting. Read More

Clin Nucl Med 2019 Mar;44(3):249-250

From the Division of Nuclear Medicine, Department of Radiology, Miller School of Medicine, University of Miami Hospital/Jackson Memorial Hospital, Miami, FL.

A 79-year-old man had carcinoid syndrome and bilateral pulmonary nodules, which were biopsy confirmed as well-differentiated neuroendocrine tumor. PET/CT with Ga-[DOTA-Tyr]-octreotate (Ga-DOTATATE) showed multiple Ga-DOTATATE-avid bilateral pulmonary nodules, left hilar lymph node, as well as diffuse increased Ga-DOTATATE uptake in the prostate. A review of the history revealed that this patient had elevated prostate-specific antigen level. Read More

Oncologist 2019 Jan 4. Epub 2019 Jan 4.

Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Background: Using data from four tertiary referral centers in the U.S., we assessed real-world treatment patterns and clinical outcomes of patients with advanced lung neuroendocrine tumors (NETs). Read More

Adv Anat Pathol 2019 Mar;26(2):75-83

Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA.

Goblet cell carcinoid (GCC) or goblet cell carcinoma is a unique mixed endocrine-exocrine neoplasm that is almost exclusively seen in the appendix. The hallmark of GCC is the concentric infiltration of the appendiceal wall by small tight clusters, nests or cords of tumor cells that exhibit a goblet cell morphology with a small compressed nucleus and conspicuous intracytoplasmic mucin. The coexistence of high-grade adenocarcinoma with GCC has been increasingly recognized as a common finding, which has been called adenocarcinoma ex GCC or mixed GCC-adenocarcinoma. Read More

Vnitr Lek 2018 ;64(10):966-969

Primary malignant tumors of small bowel constitute only about 1-2% of all gastrointestinal neoplasms. Although neuroendocrine tumors (NETs) are relatively rare, they still represent the second most common malignancy of the small bowel (after adenocarcinoma). Clinical manifestations include abdominal pain, bowel obstruction, diarrhea, weight loss and bleeding. Read More

Kyobu Geka 2018 12;71(13):1097-1101

Department of Thoracic Surgery, Ageo Central General Hospital, Ageo, Japan.

A 17-year-old girl was referred to our hospital with atelectasis of left lung due to tumor occlusion. Clearance of the tumor was performed by mechanical removal and application of Nd-YAG laser or electrocautery. The histopathological diagnosis was typical carcinoid. Read More

Expert Opin Drug Saf 2019 Jan 24;18(1):1-10. Epub 2018 Dec 24.

a Gastrointestinal Oncology Program and Experimental therapeutics, Division of Hematology/Oncology , Tufts Medical Center - Tufts University School of Medicine , Boston , MA , USA.

Introduction: Lanreotide autogel is a synthetic somatostatin analogue which has been FDA and EMA approved for unresectable, well to moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumor. Its action is mediated by its affinity to somatostatin receptors, especially sst2 and sst5 receptors. Its longer half-life offers the convenience of 4-week dosing over the need for frequent injections of short-acting somatostatin analogues. Read More

Saudi J Ophthalmol 2018 Oct-Dec;32(4):355-357. Epub 2018 Feb 23.

Pathology Service, Anatomic Pathologist, Ophthalmic Pathologist, "Hospital Español de México", Mexico City, Mexico.

We describe the clinic, image, and histopathologic features of a well differentiated neuroendocrine carcinoma (carcinoid tumour) metastatic to choroid and ciliary body in a 52-year-old Mexican Mestizo man. The ophthalmologic examination showed an inferior choroidal mass accompanied by exudative retinal detachment. Ultrasound B-Scan study revealed a diffuse thickened choroid with overlying serous retinal detachment, ultrasound A-Scan revealed a high internal reflectivity solid lesion. Read More

BMJ Case Rep 2018 Dec 22;11(1). Epub 2018 Dec 22.

Internal Medicine Residency Program, Southeast Health, Dothan, Alabama, USA.

Anaemia can present with symptoms of fatigue, shortness of breath, weakness, malaise, tachycardia and skin pallor. If left untreated, this can progress to life-threatening complications such as arrhythmias, cardiac hypertrophy and myocardial infarction. In this report, a 43-year-old woman, who was ambulatory with no exertional dysponea, presented with weakness, fatigue, bilateral lower extremity oedema and intermittent right sided chest pain for several months. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13867

Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Rationale: Malignant struma ovarii is extremely rare in the clinic. The diagnosis and modalities of treatment are still controversial. Here we describe a case of extensive peritoneal implant metastasis originating from malignant struma ovarii discovered 14 years after ovariectomy and chemotherapy. Read More

Ann Med Surg (Lond) 2018 Dec 19;36:252-255. Epub 2018 Sep 19.

Department of Medicine, Health and Life, University of L'Aquila, Piazza S, Tommasi, 67100, Coppito (AQ), Italy.

Introduction: Gastric Carcinoid Tumors (GCT) are very rare in general population, but some studies evidenced a higher incidence among bariatric surgery patients. Laparoscopic Sleeve Gastrectomy (LSG) is a widely accepted procedure for the surgical treatment of morbid obesity. LSG acts both in reducing food intake and interfering with hormonal balance in the gut-brain axis. Read More

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Read More

Front Endocrinol (Lausanne) 2018 4;9:740. Epub 2018 Dec 4.

Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, Netherlands.

Available neuroendocrine biomarkers are considered to have insufficient accuracy to discriminate patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) from healthy controls. Recent studies have demonstrated a potential role for circulating neuroendocrine specific transcripts analysis-the NETest-as a more accurate biomarker for NETs compared to available biomarkers. This study was initiated to independently validate the discriminative value of the NETest as well as the association between tumor characteristics and NETest score. Read More

J Clin Oncol 2019 Feb 13;37(4):318-327. Epub 2018 Dec 13.

Merck & Co., Inc., Kenilworth, NJ.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):293-296

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Departamento de Medicina Interna, Hospital Nacional Hipólito Unanue. Lima, Perú.

Neuroendocrine carcinoma of esophagus represents less than 2% of cases of cancer of the esophagus. This presentation is extremely unusual, as this type of carcinoma typically presents with greater frequency in bronchopulmonary regions. The symptoms are usually associated with esophageal obstruction and include odynophagia, dysphagia and weight loss and are not usually associated with Carcinoid syndrome. Read More

Cancer Chemother Pharmacol 2019 Feb 8;83(2):375-385. Epub 2018 Dec 8.

Endocrinology, DiMI and CEBR, University of Genoa, Genoa, Italy.

Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety of octreotide SC depot in patients with acromegaly and functioning NETs, previously treated with octreotide IM. Read More

J Thorac Dis 2018 Oct;10(10):5850-5859

Division of Hematology, Oncology, Blood & Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) sub-lobar resection (SL-R), is controversial. Read More

Ann Diagn Pathol 2019 Feb 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

Neuroendocrinology 2018 Nov 28. Epub 2018 Nov 28.

The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma, have not been investigated so far. The aim of this study was, therefore, to search for lung NENs, which are well-differentiated but show Ki67 values that overlap with those of poorly differentiated NENs (PD-NENs). Resected lung NENs from 244 Japanese patients were reviewed and Ki67 index was assessed in all tumors. Read More

Diagn Cytopathol 2019 Mar 28;47(3):218-221. Epub 2018 Nov 28.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Japan.

Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo-oophorectomy was performed. Read More

J Surg Oncol 2019 Jan 27;119(1):156-162. Epub 2018 Nov 27.

Department of Surgery, Division of Colorectal Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background And Objectives: Current guidelines of the American Joint Commission on Cancer (AJCC) for rectal neuroendocrine tumors (NETs) classify tumor nodal status as N0/N1. This staging does not take into consideration the number of positive lymph nodes. The goal of this study is to determine how the number of positive lymph nodes affects the prognosis for patients with rectal NETs. Read More

Turk J Surg 2018 Nov 20:1-5. Epub 2018 Nov 20.

Department of General Surgery, Bursa Yüksek İhtisas Training and Research Hospital, İstanbul, Turkey.

Objective: Appendiceal tumors are rare and mostly present as acute appendicitis. Its estimated lifetime prevalence has been reported as 8%, and the annual incidence is approximately 0.1% in Western countries. Read More

European J Pediatr Surg Rep 2018 Jan 18;6(1):e81-e82. Epub 2018 Oct 18.

Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, United Kingdom of Great Britain and Northern Ireland.

A 9-year-old boy, with previous anorectal malformation and neuropathic bladder and bowel, underwent ileocystoplasty, Monti-Mitrofanoff and appendix antegrade colonic enema procedure. The tip of the macroscopically normal appendix was sent for routine histopathology. Microscopy demonstrated a 5-mm well-differentiated neuroendocrine tumor extending into muscularis propria. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13390

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.

To evaluate association of carcinoid syndrome (CS) symptom burden and somatostatin analog (SSA) duration with quality of life (QoL) using Functional Assessment of Cancer Therapy-General (FACT-G) and Patient-Reported Outcomes Measurement Information System (PROMIS-29) instruments.Adults who received treatment for CS symptoms in the US were recruited to participate in a cross-sectional online survey (July-October, 2016). Demographic, clinical, and QoL questions (FACT-G, 29 CS-related supplemental questions, PROMIS-29) were included. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

Pancreas 2019 Jan;48(1):60-65

Department of Medicine, Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA.

Objectives: Endoscopic resection is preferred for duodenal carcinoids less than 20 mm; however, the efficacy of simple polypectomy has not been compared with advanced endoscopic resection techniques.

Methods: We performed a retrospective review of 33 patients who underwent endoscopic duodenal carcinoid resection (10 simple, 23 endoscopic mucosal resection) at the Hospital of the University of Pennsylvania between January 1, 2006, and June 15, 2017. The primary outcomes were resection margin positivity and local tumor recurrence. Read More