15,074 results match your criteria Carcinoid Tumor


Gastrointestinal and pancreatic neuroendocrine tumours and carcinomas; a review of rare tumour type.

J Pak Med Assoc 2019 Apr;69(4):533-540

Dow Institute of Radiology, Dow University of Health Sciences, Karachi, Pakistan.

Neuroendocrine tumours are a rare tumour type involving neuroectodermal cells. They are also termed carcinoids. Gastroenteropancreatic system is most commonly involved. Read More

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Dual-phase computed tomography angiography of intestinal carcinoid tumor as a lead point for cecocolic intussusception in a dog.

J Vet Med Sci 2019 Apr 17. Epub 2019 Apr 17.

College of Veterinary Medicine and BK 21 Plus Project Team, Chonnam National University.

In an 8-year-old Labrador Retriever with progressive anorexia, constipation, and depression, CT revealed intussusception of the cecum into the ascending colon and a small cecal mass showing strong enhancement on arterial phase. The ileocecocolic junction was surgically resected and histologically diagnosed as cecocolic intussusception with carcinoid tumor. The carcinoid tumor worked as a lead point of intussusception in this case. Read More

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http://dx.doi.org/10.1292/jvms.19-0101DOI Listing
April 2019
1 Read

Clinical Features of Multiple Endocrine Neoplasia Type 4 - Novel pathogenic variant and review of published cases.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Research, Faculty of Health, University of Southern Denmark (SDU).

Context: The clinical phenotype of multiple endocrine neoplasia type 4 (MEN4) is undefined due to a limited number of published cases. Knowledge on disease manifestation in MEN4 is essential for developing prevention programs and treatment.

Objective: To expand current knowledge of the MEN4 phenotype including assessment of penetrance. Read More

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http://dx.doi.org/10.1210/jc.2019-00082DOI Listing
April 2019
1 Read

A hepatic sclerosing hemangioma emerged in the postoperative course of multiple gastric carcinoid tumors masquerading as metachronous liver metastasis.

Int J Surg Case Rep 2019 Apr 4;58:1-5. Epub 2019 Apr 4.

Department of Gastrointestinal Surgery, Hokkaido Cancer Center, Sapporo, Japan.

Introduction: Hepatic sclerosing hemangiomas are rare tumors whose appearance on imaging is similar to that of malignant tumors. The resulting difficulties in preoperative diagnosis frequently lead to surgical resection in order to accurately identify the tumor.

Case Presentation: A 68-year-old man was diagnosed with multiple gastric carcinoid tumors (T1N1M0, pStage IIIB) after total gastrectomy with D2 lymph node dissection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193013
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http://dx.doi.org/10.1016/j.ijscr.2019.03.018DOI Listing
April 2019
2 Reads

Osteoporosis Circumscripta on 68Ga-DOTATATE PET CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Nuclear Medicine Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.

Incidental findings on PET CT studies are common. The distribution of Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis circumscripta is the early lytic phase of Paget disease associated with well-defined osteopenia, most commonly seen within the skull on imaging. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002567DOI Listing
April 2019
3 Reads

Incidental Uptake in Benign Gynecomastia on 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Breast Imaging and.

A 54-year-old man with mesenteric carcinoid tumor metastatic to the liver completed staging Ga-DOTATATE PET/CT demonstrating uptake in multiple hepatic lesions consistent with liver metastases with additional asymmetric increased uptake in the right greater than the left breast. Subsequent bilateral diagnostic mammogram revealed benign right greater than left gynecomastia without suspicious underlying mass. With Food and Drug Administration approval of Ga-DOTATATE and the increased use of this analog in neuroendocrine tumor imaging, this case illustrates a relevant example of uptake that can potentially mimic malignancy. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9715
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http://dx.doi.org/10.1097/RLU.0000000000002597DOI Listing
April 2019
4 Reads

[A case of carcinoid tumor diagnosed by a cardiologist].

Turk Kardiyol Dern Ars 2019 Apr;47(3):244

Gülhane Research and Education Hospital, Department of Cardiology, Turkey.

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http://dx.doi.org/10.5543/tkda.2018.85068DOI Listing

Bronchial Carcinoid Tumors with Massive Osseous Metaplasia: A Case Report and Review of the Literature.

Turk Patoloji Derg 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Erzurum Regional Training and Research Hospital, ERZURUM, TURKEY.

Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type of cellular origin has not been clearly understood. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01457DOI Listing
April 2019
1 Read

Advanced multi-modal diagnostic approaches for detection of lung cancer.

Expert Rev Mol Diagn 2019 Apr 12. Epub 2019 Apr 12.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , Shri Vile Parle Kelavani Mandal'S Narsee Monjee Institute of Management Studies University , V.L. Mehta Road, Vile Parle (W), Mumbai , Maharashtra 400056 , India .

Introduction: Lung cancer (LC) emerges as a principle cause of death among smokers and is also one of the most lethal forms of cancer in non-smokers. LC is mainly classified as non-small cell lung cancer (NSCLC), small cell lung cancer and lung carcinoid tumor. NSCLC is the most prevalent form of LC and its early stage diagnosis is essential to reduce mortality rate of patients and provide specific therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737159.2019.1
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http://dx.doi.org/10.1080/14737159.2019.1607299DOI Listing
April 2019
3 Reads

Mixed Adenoneuroendocrine Tumor of the Rectum in an Ulcerative Colitis Patient.

GE Port J Gastroenterol 2019 Mar 8;26(2):125-127. Epub 2018 Jun 8.

aGastroenterology Department, Centro Hospitalar São João, Porto, Portugal.

Patients with inflammatory bowel disease present a higher risk of colorectal cancer, especially patients with a high degree of disease activity. Although rare, carcinoid tumors can also be associated with inflammatory bowel disease. Mixed adenoneuroendocrine tumor is defined as a neoplasm with dual differentiation (neuroendocrine and adenoma) with each component accounting for at least 30% of the tumor. Read More

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https://www.karger.com/Article/FullText/489409
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http://dx.doi.org/10.1159/000489409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454396PMC
March 2019
3 Reads

Value of fluorine-18-fluorodeoxyglucose PET/CT in localizing the primary lesion in adrenocorticotropic hormone-dependent Cushing syndrome.

Nucl Med Commun 2019 May;40(5):539-544

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine.

Objective: This study aimed to present a proper understanding of the fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) value in localizing the primary lesion in adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome in a relatively large case cohort.

Patients And Methods: This retrospective study included 47 patients with ACTH-dependent Cushing syndrome, who underwent an F-FDG PET/CT examination in our hospital from November 2010 to January 2018. The serum cortisol, 24 h urine cortisol, serum ACTH, and high-dose dexamethasone suppression test were measured in all the patients. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000989DOI Listing
May 2019
1 Read

Multimodality Imaging of Ileal Neuroendocrine (Carcinoid) Tumor.

AJR Am J Roentgenol 2019 Apr 11:1-9. Epub 2019 Apr 11.

1 Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252.

Objective: The purpose of this article is to provide a multimodality imaging review of ileal carcinoid tumor.

Conclusion: Ileal carcinoid tumors display a variety of radiologic findings. Delay in diagnosis is common because of initial nonspecific symptoms and subtle imaging findings. Read More

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http://dx.doi.org/10.2214/AJR.18.21025DOI Listing
April 2019
1 Read

Spontaneous Partial Regression of a Carcinoid Tumor: Radiology May Not Capture the Real Picture.

Turk Thorac J 2019 Jan 31;20(2):153-156. Epub 2019 Jan 31.

Department of Pulmonary Medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan, India.

A partial or complete resolution of the neoplastic lesion, either spontaneously or in the presence of therapy that is considered inadequate to exert significant influence on the growth of the neoplastic lesion, is considered a spontaneous regression. This phenomenon is extremely rare in lung neoplasms. A close follow up with imaging along with bronchoscopy and a biopsy of the lesion is essential, as they may have potential for distant spread even during radiological regression. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2018.18059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453627PMC
January 2019
1 Read

A Case of Primary Ovarian Insular Carcinoid Tumor Presenting with Carcinoid Syndrome.

J Obstet Gynaecol India 2019 Apr 24;69(Suppl 1):71-75. Epub 2018 Apr 24.

Department of Endocrinology, Vivekananda Institute of Medical Sciences, 99 Sarat Bose Road, Kolkata, 700026 India.

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http://dx.doi.org/10.1007/s13224-018-1113-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431704PMC
April 2019
4 Reads

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings.

Braz J Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Erciyes University Medical Faculty, Department of Radiology, Kayseri, Turkey.

Introduction: Squamous cell carcinoma is the most common laryngeal neoplasm and accounts for approximately 95% of all malignant neoplams of the larynx. However, various benign and malignant tumors and inflammatory diseases may affect the larynx.

Objective: The purpose of this study is to analyze the clinical and imaging findings of non-squamous cell neoplasms and inflammatory diseases of the larynx. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18088694183022
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http://dx.doi.org/10.1016/j.bjorl.2019.02.003DOI Listing
March 2019
6 Reads

[Diagnosis of lung biopsy employing the 2015 WHO criteria and detection of related oncogenic driver mutations].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):270-275

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

The diagnostic criteria of lung biopsy specimens by 2015 WHO lung tumor classification were used to evaluate lung biopsy specimens along with detection of genetic alterations of major tumor driving genes including epidermal growth factor receptor (EGFR). The clinical data, histological slides, immunohistochemical stains and special stains of 806 lung biopsy specimens at Beijing Hospital from July 2015 to July 2018 were retrospectively analyzed. Diagnosis of lung cancer was reclassified according to the 2015 WHO lung tumor classification and related gene mutation data were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.002DOI Listing
April 2019
3 Reads

Periprocedural Management of Patients Undergoing Liver Resection or Embolotherapy for Neuroendocrine Tumor Metastases.

Pancreas 2019 04;48(4):496-503

Department of Anesthesiology, Yale University, New Haven, CT.

Objectives: The objective of this study was to describe the periprocedural management of patients with well-differentiated neuroendocrine tumors with hepatic metastases who underwent liver-directed procedures.

Methods: We performed a retrospective review of patients with metastatic neuroendocrine tumors who underwent liver resection, ablation, or embolotherapy at a single center from 2012 to 2016. The primary outcome was occurrence of documented carcinoid crisis (CC) or hemodynamic instability (HDI), defined as 10 minutes or more of systolic blood pressure less than 80 or greater than 180 mm Hg, or pulse greater than 120 beats per minute. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001271DOI Listing
April 2019
6 Reads

Outcomes of laparoscopic tumor ablation for neuroendocrine liver metastases: a 20-year experience.

Surg Endosc 2019 Apr 3. Epub 2019 Apr 3.

Department of Endocrine Surgery, Cleveland Clinic, 9500 Euclid Ave/F20, Cleveland, OH, 44195, USA.

Background: Since neuroendocrine tumors have an indolent behavior, studies looking at oncologic outcomes should report a long-term follow-up. Over the years, we have been treating selected patients with neuroendocrine liver metastases (NELM) with laparoscopic ablation (LA) and reported favorable local tumor control. The aim of this study is to see whether this local efficacy translates into long-term oncologic outcomes. Read More

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http://dx.doi.org/10.1007/s00464-019-06759-1DOI Listing
April 2019
1 Read

Tumor characteristics, expressions of ERCC1, Bax, p53, IGF1R, Bcl2, Bcl2/Bax and prognostic factors for overall survival in patients with lung carcinoid.

J BUON 2019 Jan-Feb;24(1):256-266

Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Purpose: Neuroendocrine lung tumors (NET) include typical carcinoids (TC), atypical carcinoids (AC), large cell NE carcinoma (LCNEC) and small-cell carcinoma (SCLC), with different clinicopathological profiles and relative grades of malignancy. Although differences between carcinoids and high grade carcinomas are recognized, precise differences and behavior of TC and AC have not been clearly defined. The aim of this study was to better define the differences in the clinical behavior of TC and AC, and to establish new prognostic factors of overall survival (OS), by determining the levels of genetic expression of IGF1R, ERCC1, Bax, p53, Bcl2 and Bcl2/Bax ratio. Read More

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April 2019
7 Reads

Mature teratoma containing carcinoid tumour arising within a fallopian tube.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

North Bristol NHS Trust, Bristol, UK.

A 52-year-old woman with a background of vaginal hysterectomy for heavy menstrual bleeding underwent an elective laparoscopic adhesiolysis, left salpingo-oophorectomy for left-sided pelvic pain, and a right salpingectomy. Despite a grossly normal appearance, histology revealed a rare presentation of mature teratoma with insular carcinoid tumour arising from the left fallopian tube. Even though the salpingectomy was thought to be curative, the patient underwent a second operation to remove her remaining right ovary as a precaution against malignant spread. Read More

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http://dx.doi.org/10.1136/bcr-2018-227630DOI Listing
March 2019
1 Read

Orthopedia homeobox protein (OTP) is a sensitive and specific marker for primary pulmonary carcinoid tumors in cytologic and surgical specimens.

J Am Soc Cytopathol 2019 Jan - Feb;8(1):39-46. Epub 2018 Oct 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.

Introduction: Orthopedia homeobox protein (OTP) was recently demonstrated to be a pulmonary neuroendocrine marker showing specificity for pulmonary carcinoid tumors in histologic sections. Little is known of OTP performance and specificity for pulmonary neuroendocrine tumors in lung fine-needle aspiration (FNA) cell blocks (CBs), however.

Materials And Methods: We evaluated OTP expression in lung non-neuroendocrine and neuroendocrine tumor CBs to determine its diagnostic utility in these specimens. Read More

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http://dx.doi.org/10.1016/j.jasc.2018.09.004DOI Listing
October 2018
2 Reads

Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices.

Mod Pathol 2019 Mar 28. Epub 2019 Mar 28.

Thoracic Oncology Service, Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The spectrum and evolution of proliferation rates in stage IV lung carcinoids is poorly defined. In particular, there are limited data on the prevalence and characteristics of tumors exceeding the standard upper proliferative criteria-as defined largely based on early-stage carcinoids-in metastatic setting. Sixty-six patients with stage IV lung carcinoids were identified, and all evaluable samples (n = 132; mean 2 samples per patient) were analyzed for mitotic counts and Ki-67 rate. Read More

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http://dx.doi.org/10.1038/s41379-019-0248-2DOI Listing
March 2019
3 Reads

Stathmin-1 is a useful diagnostic marker for high-grade lung neuroendocrine tumors.

Ann Thorac Surg 2019 Mar 22. Epub 2019 Mar 22.

Department of General Surgical Science.

Background: Stathmin-1regulates microtubule dynamics and is associated with malignant phenotypes in non-small-cell lung cancer (NSCLC). This study evaluated its diagnostic value for differentiating between NSCLC and high-grade neuroendocrine tumor (HGNET).

Methods: Stathmin-1 protein expression was assessed by immunohistochemistry (IHC) in surgical specimens of 414 NSCLC (305 adenocarcinoma [AD], 102 squamous cell carcinoma [SCC], 7 large-cell carcinoma [LA]), 5 typical carcinoid (TC; a low-grade neuroendocrine tumor), and 34 HGNET (17 small-cell carcinoma [SCLC] and 17 large-cell neuroendocrine carcinoma [LCNEC]) and biopsy specimens of 57 NSCLCs (29 AD and 28 SCC) and 42 HGNETs (17 LCNEC and 25 SCLC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193039
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http://dx.doi.org/10.1016/j.athoracsur.2019.02.040DOI Listing
March 2019
5 Reads

Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms.

Semin Diagn Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114-2696, United States. Electronic address:

Neuroendocrine paraneoplastic syndromes (PNS) consist of metabolic disorders that accompany benign and malignant neoplasms but remain unrelated to mass effects or invasion by the primary tumor or its metastases. The underlying pathogenesis responsible for PNS usual clinical presentation rely on aberrant production of protein hormones, proteins and other substances by the tumor. Prompt recognition of characteristic signs and symptoms combined with serological identification of key substances may result in early diagnosis of PNS and its underlying malignancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570193002
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http://dx.doi.org/10.1053/j.semdp.2019.03.002DOI Listing
March 2019
10 Reads

Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study.

J Clin Med 2019 Mar 23;8(3). Epub 2019 Mar 23.

Department of Clinical Oncology, AC Camargo Cancer Center, Sao Paulo 01509-900, Brazil.

The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) with neuroendocrine tumors (NETs). In terms of materials and methods, a retrospective multicenter cohort study was conducted of factors associated with CHD in advanced NET pts with carcinoid syndrome (CS) and/or elevated urinary 5-hidroxyindole acetic acid (u5HIAA). CHD was defined as at least moderate right valve alterations. Read More

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http://dx.doi.org/10.3390/jcm8030405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463128PMC
March 2019
1 Read

Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors.

J Am Coll Surg 2019 Mar 18. Epub 2019 Mar 18.

Section of Surgical Oncology, Department of Surgery, Yale School of Medicine, New Haven, CT. Electronic address:

Background: Surgical management of appendiceal carcinoid tumors is heavily debated, despite National Comprehensive Cancer Network (NCCN) guidelines recommending aggressive resection of tumors > 2 cm. We investigated national practice patterns and the predictors and impact of guideline non-adherence.

Study Design: The National Cancer Database was queried for cases of appendiceal carcinoids diagnosed from 2004 - 2015 treated with either appendectomy or hemicolectomy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10727515193018
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http://dx.doi.org/10.1016/j.jamcollsurg.2019.02.050DOI Listing
March 2019
6 Reads
5.122 Impact Factor

Transcriptional effects of Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice.

EJNMMI Res 2019 Mar 20;9(1):28. Epub 2019 Mar 20.

Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gula Stråket 2B, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden.

Background: Lu-octreotate is used for therapy of somatostatin receptor expressing neuroendocrine tumors with promising results, although complete tumor remission is rarely seen. Previous studies on nude mice bearing the human small intestine neuroendocrine tumor, GOT1, have shown that a priming injection of Lu-octreotate 24 h before the main injection of Lu-octreotate resulted in higher Lu concentration in tumor, resulting in increased absorbed dose, volume reduction, and time to regrowth. To our knowledge, the cellular effects of a priming treatment schedule have not yet been studied. Read More

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http://dx.doi.org/10.1186/s13550-019-0500-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426909PMC
March 2019
1 Read

Organizing pneumonia co-existing with carcinoid tumour: complete resolution with bronchoscopic tumour resection.

Respirol Case Rep 2019 May 7;7(4):e00409. Epub 2019 Mar 7.

Pulmonary and Critical Care University of Maryland School of Medicine Baltimore MD USA.

Organizing pneumonia is a well-known clinical entity resulting in response to noxious stimuli causing lung injury. It is known to occur with infectious disease processes, neoplasms, post lung surgery or radiation therapy and when idiopathic, is called cryptogenic organizing pneumonia. We present an unusual case of a 48-year-old woman who presented with chronic cough and progressive dyspnoea while being on macrolide therapy for Lyme disease. Read More

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http://dx.doi.org/10.1002/rcr2.409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405329PMC
May 2019
1 Read

A case of pseudocystic liver metastases from an atypical lung carcinoid tumor.

Radiol Case Rep 2019 May 6;14(5):595-601. Epub 2019 Mar 6.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

Metastatic neuroendocrine tumors of the liver typically appear as solid, hypervascular masses on imaging. Pseudocysts mimicking simple cysts are extremely rare. A 42-year-old Japanese woman was referred with a single pulmonary mass in the left lower lobe. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406078PMC
May 2019
1 Read

Endoloop ligation after endoscopic mucosal resection using a transparent cap: A novel method to treat small rectal carcinoid tumors.

World J Gastroenterol 2019 Mar;25(10):1259-1265

Department of Gastroenterology, Shenzhen People's Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China.

Background: Local endoscopic resection is an effective method for the treatment of small rectal carcinoid tumors, but remnant tumor at the margin after resection remains to be an issue.

Aim: To evaluate the efficacy and safety of resection of small rectal carcinoid tumors by endoloop ligation after cap-endoscopic mucosal resection (LC-EMR) using a transparent cap.

Methods: Thirty-four patients with rectal carcinoid tumors of less than 10 mm in diameter were treated by LC-EMR ( = 22) or endoscopic submucosal dissection (ESD) ( = 12) between January 2016 and December 2017. Read More

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http://dx.doi.org/10.3748/wjg.v25.i10.1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421235PMC
March 2019
2 Reads

Vitamin D and vitamin B deficiencies in patients with small intestinal carcinoid tumour: is opioid use disorder a confounding factor in the diagnosis?

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Allama Iqbal Medical College, Lahore, Pakistan.

Carcinoid tumours have the ability to secrete various peptides and bioamines that lead to carcinoid syndrome manifested as cutaneous flushing, diarrhoea, bronchial constriction and cardiac involvement. The deficiencies of vitamins D and B have previously been reported in patients with carcinoid tumours presumably due to chronic diarrhoea associated with the carcinoid syndrome. Herein, we chronicle the case of a patient with opioid use disorder who presented with small bowel obstruction that was found to be caused by a midgut carcinoid tumour. Read More

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http://dx.doi.org/10.1136/bcr-2018-227430DOI Listing
March 2019
2 Reads

Inhibition of Serotonin Synthesis May Have Antitumor Activity? Long-Term Efficacy in a Patient with Gastrointestinal Neuroendocrine Tumor.

Oncologist 2019 Mar 15. Epub 2019 Mar 15.

Medical Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.

In this article, we propose, based on a clinical case, the potential antitumor effect related to the inhibition of serotonin in neuroendocrine tumors (NETs). Currently, the only drug that exists for the symptomatic treatment of carcinoid syndrome refractory to somatostatin analogues is telotristat, based on its pivotal study, the TELESTAR trial. Based on the existing preclinical rationale, it seems that the inhibition of serotonin may have an antitumoral role in NETs. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0776DOI Listing
March 2019
1 Read

Gastric Neuroendocrine Tumors (Carcinoids).

Curr Gastroenterol Rep 2019 Mar 12;21(4):13. Epub 2019 Mar 12.

Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Perelman School of Medicine, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Purpose Of Review: The diagnosis of gastric neuroendocrine tumors (NETs) is being made with increased frequency likely as a result of more upper endoscopies being done for unrelated reasons. It is therefore vital that gastroenterologists become familiar with the basic work-up and management of patients found to have these tumors. This review describes the classification, pathophysiology, clinical characteristics, and treatment options of the different gastric NETs. Read More

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http://dx.doi.org/10.1007/s11894-019-0684-7DOI Listing
March 2019
1 Read

The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(10):e14769

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Background: Pulmonary carcinoids (PC) are histologically classified into typical carcinoid (TC) and atypical carcinoid (AC). The diagnosis of pulmonary carcinoid and possibly the differentiation between TC and AC could make a significant effect on the treatment planning as well as prognosis. Several studies have explored the utility of Ga-DOTA-Peptide (Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-peptide) and F-flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the evaluation of primary pulmonary carcinoids. Read More

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http://dx.doi.org/10.1097/MD.0000000000014769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417554PMC
March 2019
4 Reads

Minimally Invasive Small Bowel Cancer Surgery.

Surg Oncol Clin N Am 2019 04 24;28(2):273-283. Epub 2018 Dec 24.

Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305, USA. Electronic address:

Small bowel malignancies are extremely rare. Surgical resection is often the mainstay of treatment with the extent of the operation depending on the type of tumor. Whereas neuroendocrine tumors and adenocarcinoma require lymph node resection, gastrointestinal stromal tumors do not typically metastasize to regional nodes and therefore need resection only. Read More

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http://dx.doi.org/10.1016/j.soc.2018.11.008DOI Listing
April 2019
1 Read

Primary Renal Well-differentiated Neuroendocrine Tumor (Carcinoid): Next- Generation Sequencing Study of 11 Cases.

Histopathology 2019 Mar 9. Epub 2019 Mar 9.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Pilsen, Czech Republic.

Aims: Primary renal well-differentiated neuroendocrine tumor (hereafter referred to as renal NET) is rare, with approximately 100 cases reported in the literature. There is also limited data available on the molecular genetic background of primary renal NETs.

Methods: We analyzed 11 renal NETs using next generation sequencing (NGS) to identify characteristic genetic aberrations. Read More

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http://dx.doi.org/10.1111/his.13856DOI Listing
March 2019
2 Reads

Inoperable Pulmonary Carcinoid Tumors: Local Control Rates With Stereotactic Body Radiotherapy/Hypofractionated RT With Image-Guided Radiotherapy.

Clin Lung Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY.

Introduction: Surgery is the standard of care for pulmonary carcinoid tumors; however, options for inoperable patients are few. We report the outcomes of inoperable pulmonary carcinoid patients treated with stereotactic body radiotherapy (SBRT).

Patients And Methods: From an institutional database, we retrospectively identified patients treated with SBRT for pulmonary carcinoid tumors from 2007 to 2017. Read More

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http://dx.doi.org/10.1016/j.cllc.2019.02.003DOI Listing
February 2019
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Carcinoid Heart Disease: Review of Current Knowledge.

Tex Heart Inst J 2019 02 1;46(1):21-27. Epub 2019 Feb 1.

Carcinoid heart disease is the collective term for all cardiac manifestations in patients who have carcinoid syndrome. Carcinoid heart disease has a multifactorial pathophysiology, and the right side of the heart is usually involved. Symptoms and signs vary depending upon the affected cardiac components; most typical is right-sided heart failure secondary to diseased tricuspid and pulmonary valves. Read More

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http://dx.doi.org/10.14503/THIJ-17-6562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378997PMC
February 2019
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Automated quantification of Ki-67 index associates with pathologic grade of pulmonary neuroendocrine tumors.

Chin Med J (Engl) 2019 Mar;132(5):551-561

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by the presence of necrosis and number of mitoses per 2 mm. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416093PMC
March 2019
1 Read

Automated quantification of Ki-67 index associates with pathologic grade of pulmonary neuroendocrine tumors.

Chin Med J (Engl) 2019 Feb 20. Epub 2019 Feb 20.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: Classification of the pulmonary neuroendocrine tumor (pNET) categories is a step-wise process identified by the presence of necrosis and number of mitoses per 2 mm. In neuroendocrine tumor pathology, Ki-67 was first described as a prognostic factor in the pancreas and incorporated into the grading system of digestive tract neuroendocrine neoplasms in the 2010 WHO classification. However, the significance of Ki-67 in pNETs was still a controversial issue. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000109DOI Listing
February 2019

Current best practice in the management of neuroendocrine tumors.

Ther Adv Endocrinol Metab 2019 31;10:2042018818804698. Epub 2018 Oct 31.

First Department of Propaedeutic Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Neuroendocrine neoplasms are rare tumors that display marked heterogeneity with varying natural history, biological behavior, response to therapy and prognosis. Their management is complex, particularly as a number of them may be associated with a secretory syndrome and involve a variety of options. A number of factors such as proliferation rate, degree of differentiation, functionality and extent of the disease are mostly utilized to tailor treatment accordingly, ideally in the context of a multidisciplinary team. Read More

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http://dx.doi.org/10.1177/2042018818804698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378464PMC
October 2018
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A rare testicular tumor: primary carcinoid tumor.

Tumori 2019 Feb 24:300891619832263. Epub 2019 Feb 24.

1 Department of Pathology, University Teaching Hospital of Lomé, Togo.

Background:: Primary carcinoid tumors are rare and constitute 0.23% of all testicular tumors. We report a case of primary carcinoid tumor of testicular localization, with a review of the literature. Read More

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http://dx.doi.org/10.1177/0300891619832263DOI Listing
February 2019
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Safety and efficacy of over-the-scope clip-assisted full thickness resection of duodenal subepithelial tumors: A case report.

World J Gastrointest Endosc 2019 Feb;11(2):168-173

Department of Medicine, Division of Gastroenterology and Hepatology, University of Florida Health at Jacksonville, Jacksonville, FL 32209, United States.

Background: Over-the-scope clip-assisted endoscopic full thickness resection (eFTR) of subepithelial tumors is a novel and promising endoscopic technique. Recently, there have been prospective studies investigating its use for colonic masses, but data regarding its use and efficacy in the duodenum are limited to a few reports.

Case Summary: A 65-year-old African American female presents for evaluation of persistent gastroesophageal reflux disease not responsive to medical treatment. Read More

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http://dx.doi.org/10.4253/wjge.v11.i2.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379745PMC
February 2019
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Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report.

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

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http://dx.doi.org/10.1186/s12890-018-0767-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380005PMC
February 2019
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[Bronchial Typical Carcinoid Tumor Treated with Two-stage Resection;Report of a Case].

Kyobu Geka 2019 Feb;72(2):160-163

Department of Thoracic Surgery, Shinkoga Hospital, Kurume, Japan.

A 45-year-old woman, who had been treated for bronchial asthma, was referred to our hospital with symptoms of dyspnea. Upon examination, we found the right main bronchus to be almost completely occluded by an endobronchial tumor. For the purpose of diagnosis and relieving the dyspnea, we performed a rigid bronchoscopic tumor resection with a high frequency snare. Read More

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February 2019
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Atypical bronchial carcinoid with postobstructive mycobacterial infection: case report and review of literature.

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

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http://dx.doi.org/10.1186/s12890-019-0806-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376781PMC
February 2019
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Multifocal Small Bowel Carcinoid: Evaluation by 68Ga-DOTATATE PET.

Clin Nucl Med 2019 Apr;44(4):e308-e310

From the Department of Radiology, Division of Nuclear Medicine, Mayo Clinic, Rochester, MN.

Carcinoid is a subtype of neuroendocrine tumor, a rare group of tumors that are known to express somatostatin receptor 2. Ga-DOTATATE is a somatostatin analog that is specific for somatostatin receptor 2 and therefore allows visualization of neuroendocrine tumors. We present 2 cases of primary multifocal small bowel carcinoid evaluated using Ga-DOTATATE PET/CT, along with contrast-enhanced CT corollary findings. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002487DOI Listing
April 2019
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Efficacy of chest computed tomography prediction of the pathological TNM stage of thymic epithelial tumours.

Eur J Cardiothorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA.

Objectives: The aim of this study is to evaluate the efficacy of chest computed tomography (CT) to predict the pathological stage of thymic epithelial tumours (TET) using the recently introduced tumour, node and metastasis (TNM) staging with comparison to the modified Masaoka staging.

Methods: Preoperative chest CT examinations in cases of resected TET with sampled lymph nodes (2006-2016) were retrospectively reviewed by 2 thoracic radiologists and radiologically (r) staged using both staging systems. A thoracic pathologist reviewed all cases for the pathological (p) stage. Read More

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http://dx.doi.org/10.1093/ejcts/ezz013DOI Listing
February 2019
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Type B3 thymoma with marked neuroendocrine differentiation: Report of a case.

SAGE Open Med Case Rep 2019 1;7:2050313X19827749. Epub 2019 Feb 1.

Department of Thoracic and Cardiovascular Surgery, Osaka Medical College Hospital, Takatsuki, Japan.

Thymomas are tumors originating from the thymus epithelial cells and are the most common tumors of the anterior mediastinum. They have been classified into types A, AB, B1, B2, and B3 by the World Health Organization. Type B3 thymoma is composed of epithelial cell sheets with mild to moderate atypia and scant lymphocytes. Read More

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http://dx.doi.org/10.1177/2050313X19827749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360637PMC
February 2019
2 Reads

Case report: Ectopic ACTH secretion due to a metastatic atypical lung carcinoid tumor. From diagnosis to treatment.

Ann Endocrinol (Paris) 2019 Apr 29;80(2):137-139. Epub 2019 Jan 29.

Endocrinology, Clinique Saint Luc de Bouge, UCL, 8, rue Saint-Luc, 5004 Bouge, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ando.2018.11.004DOI Listing
April 2019
1 Read