4,154 results match your criteria Carcinoid Lung Tumors


Insulinoma-associated protein 1 immunostaining for various types of neuroendocrine tumors on FNA smears.

Cancer Cytopathol 2020 Jun 23. Epub 2020 Jun 23.

Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Insulinoma-associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin-embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied. This study investigated the performance of INSM1 staining on cytologic smears for the detection of various NETs in comparison with chromogranin (CG) and synaptophysin (SYN).

Methods: INSM1, CG, and SYN were stained on cytologic smears of 70 NETs, including 20 pancreatic NETs, 10 lung carcinoid tumors, 11 small cell lung carcinomas (SCLCs), 10 medullary thyroid carcinomas, 10 Merkel cell carcinomas, 4 thymic atypical carcinoid tumors, and 5 olfactory neuroblastomas. Read More

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http://dx.doi.org/10.1002/cncy.22310DOI Listing

NTRK and ALK rearrangements in malignant pleural mesothelioma, pulmonary neuroendocrine tumours and non-small cell lung cancer.

Lung Cancer 2020 May 24;146:154-159. Epub 2020 May 24.

Department of Medical Oncology, Austin Health, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Victoria, Australia; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia. Electronic address:

Objectives: Gene rearrangements involving NTRK1, NTRK2, NTRK3, ROS1 and ALK have been identified in many types of cancer, including non-small cell lung cancer (NSCLC). Data in malignant pleural mesothelioma (MPM), lung neuroendocrine tumors (NETs) and small-cell lung cancer (SCLC) are lacking. Given the activity of NTRK, ROS-1 and ALK inhibitors in tumors harboring gene fusions, we sought to explore such rearrangements in these less common tumors in addition to NSCLC. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.05.019DOI Listing

Immunotherapy of Ipilimumab and Nivolumab in patients with advanced neuroendocrine tumours: a subgroup analysis of the CA209-538 clinical trial for rare cancers.

Clin Cancer Res 2020 Jun 12. Epub 2020 Jun 12.

Cancer Immunobiology, Olivia Newton-John Cancer Research Institute

Purpose: Combination immunotherapy with anti-CTLA-4 and anti-PD-1 blockade has demonstrated significant clinical activity across several tumour types. Neuroendocrine tumors (NETs) are a heterogeneous group of rare tumors with limited treatment options. CA209-538 is a clinical trial of combination immunotherapy with ipilimumab and nivolumab in rare cancers, including advanced NETs. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0621DOI Listing

Development and Validation of an Individualized Nomogram for Predicting Overall Survival in Patients With Typical Lung Carcinoid Tumors.

Am J Clin Oncol 2020 Jun 2. Epub 2020 Jun 2.

Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province.

Objective: We aim to develop and validate an effective nomogram prognostic model for patients with typical lung carcinoid tumors using a large patient cohort from the Surveillance, Epidemiology, and End Results (SEER) database.

Materials And Methods: Data from patients with typical lung carcinoid tumors between 2010 and 2015 were selected from the SEER database for retrospective analysis. Univariate and multivariate Cox analysis was performed to clarify independent prognostic factors. Read More

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http://dx.doi.org/10.1097/COC.0000000000000715DOI Listing
June 2020
2.611 Impact Factor

Primary tumor standardized uptake value (SUVmax) measured on F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer.

J Cancer Res Clin Oncol 2020 Jun 3. Epub 2020 Jun 3.

Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, People's Republic of China.

Purpose: The combined small-cell lung cancer (c-SCLC) is rare and has unique clinicopathological futures. The aim of this study is to investigate F-FDG PET/CT parameters and clinicopathological factors that influence the prognosis of c-SCLC.

Methods: Between November 2005 and October 2014, surgical-resected tumor samples from c-SCLC patients who received preoperative F-FDG PET/CT examination were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00432-020-03240-8DOI Listing

Multiple liver metastases of pulmonary carcinoid successfully treated by two-stage hepatectomy combined with embolization of portal vein branches: Report of a case.

Int J Surg Case Rep 2020 29;71:319-322. Epub 2020 May 29.

Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. Electronic address:

Introduction: The prognosis of atypical pulmonary carcinoid with liver metastases is extremely poor, and patients with multiple liver metastases are often treated using non-surgical therapies. We report a case with multiple liver metastases from atypical pulmonary carcinoid that was successfully treated using two-stage hepatectomy combined with embolization of portal vein branches.

Presentation Of Case: A 48-year-old man was referred to our department after multiple liver tumors were detected in both liver lobes on computed tomography. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265047PMC

Intrapulmonary location of benign solitary fibrous tumor.

Ann Thorac Med 2020 Apr-Jun;15(2):98-101. Epub 2020 Apr 3.

Department of Radiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Region, Saudi Arabia.

Intrapulmonary solitary fibrous tumors (SFTs) are sporadic mesenchymal neoplasms that typically arise from visceral or parietal pleura. While accounting for <5% of all pleural tumors, SFTs are known to occur in nearly all bodily organs, including nasopharynx, bladder, prostate, soft tissue of neck, buttocks, extremities, and abdominal wall. Such tumors have been previously designated localized fibrous mesothelioma or pleural fibroma. Read More

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http://dx.doi.org/10.4103/atm.ATM_14_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259394PMC

Whole-exome and RNA sequencing of pulmonary carcinoid reveals chromosomal rearrangements associated with recurrence.

Lung Cancer 2020 Jul 5;145:85-94. Epub 2020 May 5.

Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan; Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.

Introduction: The majority of pulmonary carcinoid (PC) tumors can be cured by surgical resection alone, but a significant proportion of patients experience recurrence. As PC is insensitive to conventional chemotherapy, further clarification of the molecular mechanisms of metastasis is needed in order to develop targeted therapeutics.

Methods: We performed comprehensive whole-exome sequencing (WES) of primary tumors and corresponding normal lung tissues from 14 PC patients (including 4 patients who developed postsurgical distant metastasis) and RNA sequencing of primary tumors from 6 PC patients (including 4 patients who developed postsurgical distant metastasis). Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.03.027DOI Listing

Long Non-coding RNAs in Pulmonary Neuroendocrine Neoplasms.

Endocr Pathol 2020 May 9. Epub 2020 May 9.

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792-8550, USA.

Pulmonary neuroendocrine neoplasms (NENs) are classified into low-grade neuroendocrine tumors and high-grade neuroendocrine carcinomas (NECs). There are significant differences in therapeutic strategies of the different NEN subtypes, and therefore, precise classification of pulmonary NENs is critical. However, challenges in pulmonary NEN classification include overlap of diagnostic histological features among the subtypes and reduced or negative expression of neuroendocrine markers in poorly differentiated pulmonary NECs. Read More

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http://dx.doi.org/10.1007/s12022-020-09626-1DOI Listing
May 2020
1.644 Impact Factor

Endobronchial masses encountered on fine-needle aspiration biopsy: a focus on unusual entities.

Diagn Cytopathol 2020 Apr 24. Epub 2020 Apr 24.

Division of Anatomical Pathology, Tygerberg Hospital, National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Fine-needle aspiration biopsy (FNAB) is a useful technique in the evaluation of central lung tumors which is commonly encountered in clinical cytology practice. Some of these tumors may show endobronchial, polypoid growth which is readily apparent to the endoscopist. Pulmonary salivary gland-type tumors and carcinoid tumors are overall uncommon in the lung, but these tumors tend to occur centrally and show endobronchial involvement. Read More

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http://dx.doi.org/10.1002/dc.24437DOI Listing

Evaluation of Lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors.

World J Gastroenterol 2020 Apr;26(13):1513-1524

Department of Nuclear Medicine, Santiago de Compostela´s University Hospital, Santiago de Compostela 15706, A Coruña, Spain.

Background: Lu peptide receptor radionuclide therapy (PRRT) is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropancreatic neuroendocrine tumors.

Aim: To determine the impact of PRRT on quality of life, radiologic and metabolic response, overall survival, prognostic factors and toxicity.

Methods: Thirty-six patients treated with Lu-PRRT from 2016 to 2019 were included. Read More

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http://dx.doi.org/10.3748/wjg.v26.i13.1513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152518PMC

Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts.

Mod Pathol 2020 Apr 14. Epub 2020 Apr 14.

Quebec Heart and Lung Institute Research Center, Quebec City, QC, Canada.

Pulmonary neuroendocrine neoplasms are classified by WHO as either typical or atypical carcinoids, large cell (LCNEC) or small cell (SCLC) neuroendocrine carcinoma based on mitotic count, morphology, and necrosis assessment. LCNEC with low mitotic count and sharing morphologic features with carcinoids are in a gray zone for classification and their rare prevalence and the paucity of studies precludes proper validation of the current grading system. In this study, we aim to investigate their clinicopathological and transcriptomic profiles. Read More

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http://dx.doi.org/10.1038/s41379-020-0538-8DOI Listing

Novel Findings on SPECT-CT Tc-99 Sestamibi Imaging for Primary Hyperparathyroidism.

J Surg Res 2020 Aug 11;252:216-221. Epub 2020 Apr 11.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Background: The addition of SPECT-CT to Tc-99 sestamibi has become a valuable tool for parathyroid localization in primary hyperparathyroidism (PHP). However, the enhanced sensitivity of this test can lead to unexpected and significant findings. We sought to identify the frequency and types of nonparathyroid detections by SPECT-CT. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.014DOI Listing

A primary neuroendocrine tumor of the left ventricle presenting with diarrhea-an unusual experience and literature review.

Diagn Pathol 2020 Apr 3;15(1):32. Epub 2020 Apr 3.

Department of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: Neuroendocrine tumors (NETs) can secrete bioactive amines in the bloodstream, resulting in the carcinoid syndrome characterized by diarrhea and flushing. The frequency of occurrence of primary cardiac neuroendocrine neoplasms is lesser than that of metastases, and hence, metastases must be adequately ruled out before diagnosis. Cardiac tumors, both primary and metastatic, mainly result in heart-related symptoms, such as heart failure and acquired valvular dysfunction. Read More

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http://dx.doi.org/10.1186/s13000-020-00935-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119177PMC

Clinicopathological characteristics and genetic analysis of pulmonary carcinoid tumors: A single-center retrospective cohort study and literature review.

Oncol Lett 2020 Mar 24;19(3):2446-2456. Epub 2020 Jan 24.

Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

Pulmonary carcinoid tumors, including typical and atypical carcinoids, are well-differentiated neuroendocrine tumors (NETs) that represent 1-2% of all lung cancer cases. In the present study, all cases of well-differentiated NETs diagnosed at Tianjin Medical University General Hospital (Tianjin, China) between 2006 and 2016 were reviewed, and 20 pulmonary carcinoid cases were identified. The clinical features of these cases were summarized, and the results of pathological and imaging examinations were collated. Read More

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http://dx.doi.org/10.3892/ol.2020.11347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039106PMC

Neuroendocrine tumors of the lung: clinicopathological and molecular features.

Surg Today 2020 Mar 19. Epub 2020 Mar 19.

Division of Chest Surgery, Department of Surgery, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan.

In 1970, neuroendocrine tumors of the lung were classified into three categories: typical carcinoid (TC), atypical carcinoid (AC), and small cell lung carcinoma (SCLC). The third edition of the World Health Organization (WHO) classification in 1999 defined large cell neuroendocrine carcinoma (LCNEC) as a variant of large cell carcinomas, whereas the fourth edition of the WHO classification redefined LCNEC as a neuroendocrine tumor. Currently, neuroendocrine tumors of the lung are classified into four main categories: TC, AC, LCNEC, and SCLC. Read More

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http://dx.doi.org/10.1007/s00595-020-01988-7DOI Listing

A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors.

J Immunother Cancer 2020 Mar;8(1)

Sarah Cannon Research Institute, Nashville, Tennessee, USA.

Background: Spartalizumab is a humanized IgG4κ monoclonal antibody that binds programmed death-1 (PD-1) and blocks its interaction with PD-L1 and PD-L2. This phase 1/2 study was designed to assess the safety, pharmacokinetics, and preliminary efficacy of spartalizumab in patients with advanced or metastatic solid tumors.

Methods: In the phase 1 part of the study, 58 patients received spartalizumab, intravenously, at doses of 1, 3, or 10 mg/kg, administered every 2 weeks (Q2W), or 3 or 5 mg/kg every 4 weeks (Q4W). Read More

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http://dx.doi.org/10.1136/jitc-2020-000530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073791PMC

Neuroendocrine metastases to the ovaries are significantly associated with small bowel neuroendocrine tumors and carcinomatosis.

Am J Surg 2020 05 25;219(5):795-799. Epub 2020 Feb 25.

Division of Surgical Oncology, Oregon Health & Science University, USA. Electronic address:

Introduction: Neuroendocrine tumors (NETs) metastatic to the ovary are traditionally considered rare, but data are lacking. This study seeks to better characterize the prevalence and outcomes of patients with neuroendocrine ovarian metastases (NOM).

Methods: Women with well-differentiated lung and gastroenteropancreatic NETs 2007-2017 were identified by medical record query. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.040DOI Listing

Typical and atypical carcinoid tumors of the lung: a clinicopathological correlation of 783 cases with emphasis on histological features.

Hum Pathol 2020 Apr 5;98:98-109. Epub 2020 Mar 5.

Department of Thoracic Surgery, M D Anderson Cancer Center, Houston, TX, 77030, USA.

We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.02.005DOI Listing
April 2020
2.769 Impact Factor

Endoscopic Resection of a Pediatric Carcinoid Lung Tumor Presenting as Persistent Pneumonia.

S D Med 2020 Feb;73(2):54-58

Department of Pediatrics, Avera McKennan Children's Hospital and University Health Center.

Primary lung tumors are very rare in children and constitute only 0.2 percent of all pediatric malignancies. Carcinoids are the most common primary pediatric lung tumor and account for 80 percent of all primary malignant bronchial tumors. Read More

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February 2020

Somatostatin Analogs in Clinical Practice: a Review.

Int J Mol Sci 2020 Feb 29;21(5). Epub 2020 Feb 29.

Department of Endocrinology, "La Paz" University Hospital. Paseo de la Castellana, 261, 28046 Madrid, Spain.

Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative to corticotropinomas, gonadotropinomas, and prolactinomas resistant to dopamine agonists. Somatostatin analogs have also shown to be useful in the treatment of other endocrine diseases (congenital hyperinsulinism, Graves' orbitopathy, diabetic retinopathy, diabetic macular edema), non-endocrine tumors (breast, colon, prostate, lung, and hepatocellular), and digestive diseases (chronic refractory diarrhea, hepatorenal polycystosis, gastrointestinal hemorrhage, dumping syndrome, and intestinal fistula). Read More

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http://dx.doi.org/10.3390/ijms21051682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084228PMC
February 2020

Cancer stem-neuroendocrine cells in an atypical carcinoid case report.

Transl Lung Cancer Res 2019 Dec;8(6):1157-1162

Division of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Lung neuroendocrine cells tumor (NET) classification and diagnosis, particularly for typical and atypical carcinoids, are complicated by a variable natural history and nonspecific symptoms. Mechanisms for the development and progression of well-differentiated lung NETs are still unclear. An accurate and timely diagnosis can ensure the implementation of appropriate treatment and impact on prognosis. Read More

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http://dx.doi.org/10.21037/tlcr.2019.12.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976366PMC
December 2019

Lung Cancer Pathology: Current Concepts.

Authors:
William D Travis

Clin Chest Med 2020 Mar 2;41(1):67-85. Epub 2020 Jan 2.

Thoracic Pathology, Department of Pathology, Memorial Sloan Kettering Cancer Center, Room A525, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

Lung cancer can be diagnosed based on histologic biopsy or cytologic specimens. The 2015 World Health Organization Classification of Lung Tumors addressed the diagnosis of lung cancer in resection specimens and in small biopsies and cytology specimens. For these small specimens, diagnostic terms and criteria are recommended. Read More

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http://dx.doi.org/10.1016/j.ccm.2019.11.001DOI Listing

Next generation sequencing can be helpful in histologic diagnosis: A case report of metastatic breast cancer mimicking atypical carcinoid tumor of lung.

Pathol Res Pract 2020 May 20;216(5):152835. Epub 2020 Jan 20.

Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Development of molecular technology has led to the expansion of next generation sequencing (NGS) in area of diagnostic pathology. Here we present a case in which a lung tumor, which resembled an atypical carcinoid tumor, was revealed as metastatic breast cancer by next generation sequencing. A 50-year-old female, who had received modified radical mastectomy for breast cancer, presented with a 2. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152835DOI Listing
May 2020
1.562 Impact Factor

Primary malignant lung tumors in children: A report from the Australian Childhood Cancer Registry, 1983-2015.

Pediatr Pulmonol 2020 03 7;55(3):719-722. Epub 2020 Jan 7.

Cancer Council Queensland, Brisbane, Queensland, Australia.

Lung cancers in children under the age of 15 are very uncommon, with a scarcity of literature describing patient characteristics and survival. This study assessed first primary malignant cancers occurring in the trachea, bronchus, or lung (International Classification of Diseases for Oncology, 3rd edition [ICD-O-3] codes C33-C34) for the period 1983-2015, using data from the population-based Australian Childhood Cancer Registry. Variables of interest included morphology, sex, age group, and metastatic status at diagnosis. Read More

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http://dx.doi.org/10.1002/ppul.24636DOI Listing

99mTc-EDDA/HYNIC-TOC is a new opportunity in Neuroendocrine Tumors of the Lung (and in other malignant and benign pulmonary diseases) .

Curr Radiopharm 2019 Dec 30. Epub 2019 Dec 30.

Section Health and Development, Interuniversity Research Center for Sustainability (CIRPS), Napoli, Italy.

Neuroendocrine tumors (NETs) consist of a relatively rare spectrum of malignancies that can arise from neuroendocrine cells; lung NETs (L-NETs) represent about 25% of primary lung neoplasm and 10% of all carcinoid tumors. Diagnostic algorithm usually takes into consideration chest X-ray, contrast-enhanced CT and MRI. Nuclear medicine plays a crucial role in the detection and correct assessment of neoplastic functional status as it provides in vivo metabolic data related to the over-expression of Somatostatin Receptors (SSTRs) and also predicting response to peptide receptor radionuclide therapy (PRRT). Read More

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http://dx.doi.org/10.2174/1874471013666191230143610DOI Listing
December 2019

Role of Adjuvant Chemotherapy in Pulmonary Carcinoids: An NCDB Analysis.

Anticancer Res 2019 Dec;39(12):6835-6842

Division of Hematology & Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine, Buffalo, NY, U.S.A.

Background/aim: Typical carcinoids (TC) and atypical carcinoids (AC) are rare diseases. A paucity of randomized studies and disagreements among various guidelines makes the management challenging.

Patients And Methods: Using codes for TC (8240) and AC (8249) in the National Cancer Database (NCDB), all surgically resected cases from 2004-2014 were included to evaluate the need for adjuvant chemotherapy. Read More

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http://dx.doi.org/10.21873/anticanres.13900DOI Listing
December 2019
1.872 Impact Factor

Stereotactic body radiation therapy versus fractionated radiation therapy for early-stage bronchopulmonary carcinoid.

Lung Cancer Manag 2019 Aug 21;8(3):LMT14. Epub 2019 Aug 21.

Allegheny Health Network Cancer Institute, Division of Radiation Oncology, 320 E. North Ave, Pittsburgh, PA 15212, USA.

Aim: To compare trends and outcomes in early stage bronchopulmonary carcinoid (BPC) tumors treated nonoperatively with conventionally fractionated radiotherapy (CFRT) and stereotactic body radiotherapy (SBRT).

Methods/materials: We queried the National Cancer Database for primary (typical) BPC staged cT1-2N0M0 and treated nonsurgically with lung-directed radiation and ≥1 month of follow-up. Odds ratios were used to predict likelihood of SBRT treatment and multivariable Cox regression determined predictors of survival. Read More

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http://dx.doi.org/10.2217/lmt-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891931PMC

A typical carcinoid of the lung - a case report with pathological correlation and propagation of the cancer stem cell line BKZ1 with synaptophysin expression.

Medicine (Baltimore) 2019 12;98(49):e18174

Department of General Thoracic Surgery, Protestant Hospital of Bethel Foundation, Burgsteig 13.

Rationale: Neuroendocrine tumors (NETs) of the lung account for 5% of all cases of lung cancer, which itself is the leading cause of cancer-related death worldwide. In accordance to its rarity, only few cell lines of NETs exist, which even often lack key characteristics of the primary tumor, making it difficult to study underlying molecular mechanisms.

Patient Concerns: The patient reported in this case is a 71-year old woman, which never smoked but suffered under dry cough. Read More

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http://dx.doi.org/10.1097/MD.0000000000018174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919531PMC
December 2019

Treatment of atypical pulmonary carcinoid with combination ipilimumab and nivolumab.

BMJ Case Rep 2019 Nov 28;12(11). Epub 2019 Nov 28.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

Atypical pulmonary carcinoid (APC) is a lung neuroendocrine neoplasm (NEN), whose treatment draws from management of gastrointestinal NENs and small-cell lung carcinoma. We present a patient with recurrent metastatic APC and persistent mediastinal lymphadenopathy refractory to cisplatin and etoposide. After pursuing alternative treatments, he returned with significant progression, including diffuse subcutaneous nodules, weight loss and worsening cough. Read More

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http://dx.doi.org/10.1136/bcr-2019-231029DOI Listing
November 2019

[A Case of Pulmonary Carcinoid That Has Regressed Spontaneously].

Gan To Kagaku Ryoho 2019 Nov;46(11):1771-1774

Dept. of Internal Medicine, Japan Community Healthcare Organization Osaka Hospital.

A 65-year-old woman who had diabetes mellitus was referred to the Department of Diabetes Internal Medicine of our hospital in June 201X due to disease progression. Chest radiography revealed an abnormal shadow, and computed tomography( CT)showed a 2 cm nodular shadow in the right S10. Lung cancer was suspected because of increased serum progastrin- releasing peptide(ProGRP)level and smoking history. Read More

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November 2019

A rare case of pulmonary typical carcinoid with prominent acinic cell differentiation, resembling acinic cell carcinoma.

Pathol Int 2019 Dec 14;69(12):721-726. Epub 2019 Nov 14.

Departments of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

We herein describe a rare case of low-grade endobronchial tumor that exhibited two distinct features of typical carcinoid and acinic cell carcinoma (ACC) by immunohistochemical and ultrastructure study. ACC was suspected on transbronchial biopsy. The resected specimen showed that the tumor surface comprised an acinic cell component (40% of the tumor), and the central area comprised typical carcinoid (60% of the tumor). Read More

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http://dx.doi.org/10.1111/pin.12869DOI Listing
December 2019

Pulmonary carcinoid presenting with persistent pneumothorax.

BMJ Case Rep 2019 Nov 10;12(11). Epub 2019 Nov 10.

Division of Endocrinology, Department of Internal Medicine, Duke University Hospital, Durham, North Carolina, USA

Lung neuroendocrine tumours (Lung NETs) are a rare group of pulmonary neoplasms often characterised by insidious clinical behaviour. Lung NET account for ~1%-2% of all lung malignancies in adults and 30% of all NETs. Incidence ranges from 0. Read More

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http://dx.doi.org/10.1136/bcr-2019-231083DOI Listing
November 2019

High metabolic tumour volume on FDG PET predicts poor survival from neuroendocrine neoplasms.

Neuroendocrinology 2019 Nov 12. Epub 2019 Nov 12.

Introduction: 18-Fluorodeoxyglucose (18F-FDG) PET avidity in neuroendocrine neoplasms (NENs) has been associated with higher grade disease. 18F-FDG avidity and high SUVmax have been demonstrated to predict poor outcome. Quantitative metrics of 18F-FDG PET, specifically metabolic tumour volume (MTV) and total lesion glycolysis (TLG), have been shown to be prognostic factors in other malignancies, but these have not been investigated to date in NENs. Read More

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http://dx.doi.org/10.1159/000504673DOI Listing
November 2019

Staging System for Neuroendocrine Tumors of the Lung Needs to Incorporate Histologic Grade.

Ann Thorac Surg 2020 04 7;109(4):1009-1018. Epub 2019 Nov 7.

Division of Thoracic Surgery, Swedish Cancer Institute, Seattle, Washington. Electronic address:

Background: Neuroendocrine tumors of the lung are staged with the American Joint Committee on Cancer (AJCC) TNM system for non-small cell lung cancer. However neuroendocrine tumors have a distinct clinical behavior with grade providing critical prognostic information. We aim to determine components of a tumor-specific staging system. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.09.053DOI Listing

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: Review of the Literature and a Single-center Experience.

Cureus 2019 Sep 13;11(9):e5640. Epub 2019 Sep 13.

Pathology, Hospital Universitario De Torrejón, Madrid, ESP.

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder that is commonly underdiagnosed. In 2015, it was recognized by the World Health Organization (WHO) classification of lung tumors as a premalignant lesion. DIPNECH syndrome is characterized by cough, exertional dyspnea, wheezing, and, less frequently, hemoptysis. Read More

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http://dx.doi.org/10.7759/cureus.5640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822881PMC
September 2019

Neuroendocrine Tumors of the Lung: Updates and Diagnostic Pitfalls.

Authors:
Yin P Hung

Surg Pathol Clin 2019 Dec 27;12(4):1055-1071. Epub 2019 Sep 27.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

Neuroendocrine tumors of the lung constitute approximately 20% of all primary lung tumors and include typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. Given their morphologic overlap with diverse mimics, neuroendocrine tumors of the lung can be diagnostically challenging. This review discusses the clinical, histologic, immunophenotypic, and molecular features of pulmonary neuroendocrine tumors, along with common diagnostic pitfalls and strategies for avoidance. Read More

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http://dx.doi.org/10.1016/j.path.2019.08.012DOI Listing
December 2019

[Segmentectomy in patients with primary pulmonary malignancies].

Khirurgiia (Mosk) 2019 (10):5-12

Herzen Moscow Oncology Research Institute - Branch of the National Medical Radiology Research Center, Moscow, Russia.

Objective: To analyze immediate and long-term results of anatomical resections for lung cancer with subsequent comparison of the results of segmentectomy and lobectomy in patients with peripheral NSCLC stage IA1-2.

Material And Methods: There were 52 sublobular anatomical resections of the lung for peripheral non-small cell carcinoma and carcinoid T1a-bN0M0, IA1-2 stage. 3D-CT reconstruction with separation of bronchial and vascular structures was used to schedule complex segmentectomy. Read More

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http://dx.doi.org/10.17116/hirurgia20191015DOI Listing
October 2019
1 Read

SATB2 protein expression by immunohistochemistry is a sensitive and specific marker of appendiceal and rectosigmoid well differentiated neuroendocrine tumours.

Histopathology 2020 Mar 24;76(4):550-559. Epub 2020 Jan 24.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Aims: Neuroendocrine neoplasms (NNs) range from well to poorly differentiated and indolent to highly aggressive. The site of origin in metastatic NNs has therapeutic and prognostic implications. SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium. Read More

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http://dx.doi.org/10.1111/his.14012DOI Listing
March 2020
3 Reads

Co-occurrence of breast cancer and neuroendocrine tumours: New genetic insights beyond Multiple Endocrine Neoplasia syndromes.

Endocrinol Diabetes Metab 2019 Oct 8;2(4):e00092. Epub 2019 Sep 8.

Division of Endocrinology and Metabolism Department of Medicine University Health Network University of Toronto Toronto Ontario Canada.

Objective: Age-standardized incidence of female breast cancer is 145.1 per 100000/year and 5.86 per 100000/year for neuroendocrine tumours (NET) in Canada. Read More

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http://dx.doi.org/10.1002/edm2.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775469PMC
October 2019
2 Reads

Reply.

Ann Thorac Surg 2020 03 4;109(3):990. Epub 2019 Oct 4.

Division of Thoracic Surgery, Swedish Cancer Institute, 900-1101 Madison St, Seattle, WA 98104. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2019.08.100DOI Listing
March 2020
1 Read

[Pulmonary carcinoids and carcinoids of the small intestine].

Radiologe 2019 Nov;59(11):968-974

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, LMU München, Marchioninistraße 15, 81377, München, Deutschland.

Clinical/methodical Issue: Pulmonary carcinoids and carcinoids of the small intestine (jejunum and ileum) are often asymptomatic and can affect various parts of the body, which makes diagnosis difficult.

Standard Radiological Methods: Contrast-enhanced computed tomography (CE-CT) is commonly used for primary diagnostics. In case of concomitant pulmonary consolidation (e. Read More

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http://dx.doi.org/10.1007/s00117-019-00597-xDOI Listing
November 2019
2 Reads

[Standardization of VATS lobectomies in our department between 2011-2017 in regard to results of their oncological follow-ups].

Magy Seb 2019 Sep;72(3):98-102

Általános és Mellkassebészeti Osztály, Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelőintézet 5000 Szolnok, Tószegi u. 21.

: Authors present their 7-year experience since the introduction of minimal-invasive (VATS) lobectomies for lung cancer in regard to their surgical technique, results and oncological follow-up. 173 VATS lobectomies were performed between June 2011 and December 2017, 105 men and 68 women. The mean age of patients was 64. Read More

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http://dx.doi.org/10.1556/1046.72.2019.3.2DOI Listing
September 2019
5 Reads

Spread of hyperplastic pulmonary neuroendocrine cells into air spaces (S.H.I.P.M.E.N.T.S): A proof for artifact.

Lung Cancer 2019 11 13;137:43-47. Epub 2019 Sep 13.

Division of Thoracic Surgery, IRCCS MultiMedica, Milan, Italy.

Objectives: Spread through air spaces (STAS) is a recently proposed invasion way of lung cancer, including neuroendocrine (NE) neoplasms. However, if this phenomenon is a real one or an artifact while manipulating lung specimens, it is still matter of debate.

Material And Methods: Three consecutive patients with newly diagnosed diffuse idiopathic pulmonary NE cell hyperplasia (DIPNECH) were reviewed for STAS. Read More

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http://dx.doi.org/10.1016/j.lungcan.2019.09.006DOI Listing
November 2019
1 Read

Adrenocorticotropic Hormone-Secreting, Subcentimetre Lung Carcinoid Identified by 68Gallium-DOTATATE Positron Emission Tomography Scan.

Authors:
Run Yu

Sultan Qaboos Univ Med J 2019 May 8;19(2):e166-e167. Epub 2019 Sep 8.

Division of Endocrinology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.18295/squmj.2019.19.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736268PMC

Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment.

J Bras Pneumol 2019 Sep 16;45(5):e20180140. Epub 2019 Sep 16.

. A.C. Camargo Cancer Center, São Paulo (SP) Brasil.

Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms.

Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Read More

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http://dx.doi.org/10.1590/1806-3713/e20180140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247769PMC
September 2019
4 Reads

Primary Pulmonary Involvement in Mucosa-associated Lymphoid Tissue Lymphoma.

Cureus 2019 Jul 9;11(7):e5110. Epub 2019 Jul 9.

Internal Medicine, Texas A&M Health Science Center, Temple, USA.

Pulmonary nodules have a broad differential diagnosis with primary lung cancer, lung metastases, benign tumors, carcinoid tumors, and infectious granulomas as their common cause. While relatively rare, pulmonary lymphoproliferative disorders such as primary pulmonary lymphomas, primary pulmonary plasmacytomas, secondary lymphomas involving the lung, multiple myeloma involving the lung, leukemias involving the lung should be considered in these patients presenting with lung nodules. Primary pulmonary non-Hodgkin's lymphoma (NHL) is an extremely rare lung tumor accounting for 0. Read More

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https://www.cureus.com/articles/20787-primary-pulmonary-invo
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http://dx.doi.org/10.7759/cureus.5110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741394PMC
July 2019
2 Reads

Two cases of lung neuroendocrine carcinoma with carcinoid morphology.

Diagn Pathol 2019 Sep 12;14(1):104. Epub 2019 Sep 12.

Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama City, Kanagawa, 236-0004, Japan.

Background: The category of grade 3 neuroendocrine tumor (NET G3) was newly introduced in the 2017 World Health Organization (WHO 2017) classification of neuroendocrine neoplasms of the pancreas. Pancreatic NET G3 shows a carcinoid-like morphology with high proliferative activity and the prognosis is intermediate between NET G2 and neuroendocrine carcinoma. There is no category corresponding to NET G3 in the current WHO 2015 classification of lung tumors. Read More

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http://dx.doi.org/10.1186/s13000-019-0886-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739931PMC
September 2019
1 Read

Loss of ATRX expression predicts worse prognosis in pulmonary carcinoid tumors.

Hum Pathol 2019 12 6;94:78-85. Epub 2019 Sep 6.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Loss of alpha thalassemia/mental retardation syndrome X-linked (ATRX), a chromatin regulator, is associated with worse prognosis in pancreatic neuroendocrine tumors. We investigated ATRX expression in pulmonary carcinoid tumors (PCT) and its diagnostic and prognostic role in these patients. Resected PCTs (1997-2017) were reviewed. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.08.022DOI Listing
December 2019
2 Reads