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Rev Gastroenterol Peru 2018 Jul-Sep;38(3):293-296

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Departamento de Medicina Interna, Hospital Nacional Hipólito Unanue. Lima, Perú.

Neuroendocrine carcinoma of esophagus represents less than 2% of cases of cancer of the esophagus. This presentation is extremely unusual, as this type of carcinoma typically presents with greater frequency in bronchopulmonary regions. The symptoms are usually associated with esophageal obstruction and include odynophagia, dysphagia and weight loss and are not usually associated with Carcinoid syndrome. Read More

Indian J Surg Oncol 2018 Dec 7;9(4):613-617. Epub 2018 Aug 7.

Parvarish Nursing Home, Andheri, Mumbai, Maharashtra India.

Cancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Read More

Cancer Chemother Pharmacol 2018 Dec 8. Epub 2018 Dec 8.

Endocrinology, DiMI and CEBR, University of Genoa, Genoa, Italy.

Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety of octreotide SC depot in patients with acromegaly and functioning NETs, previously treated with octreotide IM. Read More

J Thorac Cardiovasc Surg 2018 Oct 3. Epub 2018 Oct 3.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minn.

Objective: Carcinoid heart disease is characterized by tricuspid valve regurgitation and varying degrees of pulmonary valve regurgitation or stenosis. Valve replacement procedures may be complicated by systemic effects of carcinoid syndrome, as well as hepatic dysfunction and right heart failure. This study was performed to identify factors that might be associated with improving early mortality rates and late outcomes. Read More

Dig Dis Sci 2018 Dec 5. Epub 2018 Dec 5.

Division of Gastroenterology and Liver Disease, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Wearn 244, Cleveland, OH, 44106, USA.

Background And Aims: Most carcinoid tumors of the gastrointestinal tract are located in the small bowel (SB). Epidemiological studies of these tumors have been limited by small sample sizes. Our aim was to evaluate the epidemiology of SB carcinoids (SBCs) using a large database. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1223-1229

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Read More

J Thorac Dis 2018 Oct;10(10):5850-5859

Division of Hematology, Oncology, Blood & Marrow Transplantation, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) sub-lobar resection (SL-R), is controversial. Read More

Ann Diagn Pathol 2018 Nov 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

Neuroendocrinology 2018 Nov 28. Epub 2018 Nov 28.

The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma, have not been investigated so far. The aim of this study was, therefore, to search for lung NENs, which are well-differentiated but show Ki67 values that overlap with those of poorly differentiated NENs (PD-NENs). Resected lung NENs from 244 Japanese patients were reviewed and Ki67 index was assessed in all tumors. Read More

Diagn Cytopathol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Japan.

Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo-oophorectomy was performed. Read More

Ecancermedicalscience 2018 25;12:879. Epub 2018 Oct 25.

Instituto do Câncer do Estado de São Paulo, University of São Paulo, São Paulo, Brazil.

Background: Patients with carcinoid syndrome (CS) may present carcinoid heart disease (CHD) but prognostic factors are not entirely understood.

Patients And Methods: Retrospective study of patients with metastatic neuroendocrine tumours (NETs) and CS and/or abnormal 24-hour-urinary 5-hydroxiindolacetic acid. CHD was defined as moderate to severe tricuspid or pulmonary regurgitation in the echocardiogram. Read More

J Surg Oncol 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, Division of Colorectal Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background And Objectives: Current guidelines of the American Joint Commission on Cancer (AJCC) for rectal neuroendocrine tumors (NETs) classify tumor nodal status as N0/N1. This staging does not take into consideration the number of positive lymph nodes. The goal of this study is to determine how the number of positive lymph nodes affects the prognosis for patients with rectal NETs. Read More

Clin Ther 2018 Nov 23. Epub 2018 Nov 23.

Dana-Farber Cancer Institute, Boston, MA, USA.

Purpose: Patients with metastatic neuroendocrine tumors and carcinoid syndrome (CS) may experience chronic, recurring symptoms despite somatostatin analogue therapy. Little is known about the relationship between bowel movement (BM) frequency, patient-reported symptoms and health-related quality of life (QoL). Data from the TELESTAR study were used in exploratory, post hoc analyses to understand the relationship between durable reductions in BM frequency, symptom relief, and health-related QoL. Read More

Turk J Surg 2018 Nov 20:1-5. Epub 2018 Nov 20.

Department of General Surgery, Bursa Yüksek İhtisas Training and Research Hospital, İstanbul, Turkey.

Objective: Appendiceal tumors are rare and mostly present as acute appendicitis. Its estimated lifetime prevalence has been reported as 8%, and the annual incidence is approximately 0.1% in Western countries. Read More

European J Pediatr Surg Rep 2018 Jan 18;6(1):e81-e82. Epub 2018 Oct 18.

Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, United Kingdom of Great Britain and Northern Ireland.

A 9-year-old boy, with previous anorectal malformation and neuropathic bladder and bowel, underwent ileocystoplasty, Monti-Mitrofanoff and appendix antegrade colonic enema procedure. The tip of the macroscopically normal appendix was sent for routine histopathology. Microscopy demonstrated a 5-mm well-differentiated neuroendocrine tumor extending into muscularis propria. Read More

J Egypt Natl Canc Inst 2018 Dec 22;30(4):151-158. Epub 2018 Nov 22.

Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt. Electronic address:

Background: The spectrum of lung neuroendocrine tumors (NETs) encompasses low grade typical carcinoid (TC), intermediate grade atypical carcionid (AC) and high grade, both large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), with extreme differences in management and survival.

Objective: To study clinicopathologic and prognostic factors affecting survival of lung NETs.

Patients And Methods: This is a retrospective study evaluating 35 patients with primary lung NETs treated at National Cancer Institute of Egypt (NCI-E) between January 2010 and December 2014. Read More

Heart 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.

Clinical Introduction: A 57-year-old man from the USA with a history of atrial fibrillation and hypertension was evaluated for progressive dyspnoea and decreased energy. The patient denied a history of congestive heart failure, systemic symptoms or myocardial infarction. He was found to have a 3/6 holosystolic murmur radiating to the axilla. Read More

Ann Surg Oncol 2018 Nov 21. Epub 2018 Nov 21.

Virginia Mason Hospital and Seattle Medical Center, Virginia Mason Cancer Institute, Seattle, WA, USA.

Medicine (Baltimore) 2018 Nov;97(47):e13390

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.

To evaluate association of carcinoid syndrome (CS) symptom burden and somatostatin analog (SSA) duration with quality of life (QoL) using Functional Assessment of Cancer Therapy-General (FACT-G) and Patient-Reported Outcomes Measurement Information System (PROMIS-29) instruments.Adults who received treatment for CS symptoms in the US were recruited to participate in a cross-sectional online survey (July-October, 2016). Demographic, clinical, and QoL questions (FACT-G, 29 CS-related supplemental questions, PROMIS-29) were included. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

Pancreas 2019 Jan;48(1):60-65

Department of Medicine, Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA.

Objectives: Endoscopic resection is preferred for duodenal carcinoids less than 20 mm; however, the efficacy of simple polypectomy has not been compared with advanced endoscopic resection techniques.

Methods: We performed a retrospective review of 33 patients who underwent endoscopic duodenal carcinoid resection (10 simple, 23 endoscopic mucosal resection) at the Hospital of the University of Pennsylvania between January 1, 2006, and June 15, 2017. The primary outcomes were resection margin positivity and local tumor recurrence. Read More

Dis Colon Rectum 2018 Nov 15. Epub 2018 Nov 15.

Background: Given the significant perioperative risks and costs of total mesorectal excision, minimally invasive transanal surgical approaches have grown in popularity for early rectal cancer and rectal polyps. This article discusses a transanal robotic surgery technique to perform full-thickness resections of benign and malignant rectal neoplasms.

Objective: The purpose of this study was to describe an initial experience with robotic transanal minimally invasive surgery. Read More

Scand J Gastroenterol 2018 Nov 19:1-10. Epub 2018 Nov 19.

e Department of Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden.

Objectives: To quantify healthcare resource use (HRU) and costs in relation to carcinoid syndrome (CS) and carcinoid heart disease (CHD) in a real-world setting, and to provide perspective on treatment patterns.

Materials And Methods: Patient data and HRU were collected retrospectively from three Swedish healthcare registers. Adult patients diagnosed with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) grade 1 or 2 and CS who purchased somatostatin analogs (SSAs), and experienced controlled (defined by SSAs use) and uncontrolled (defined by SSAs dose escalation) CS for ≥8 months during the study period were included. Read More

Surg Pathol Clin 2018 Dec;11(4):825-836

Department of Pathology, The Johns Hopkins Medical Institutions, Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231-2410, USA; Department of Urology, The Johns Hopkins Medical Institutions, Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231-2410, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231-2410, USA. Electronic address:

Certain tumors are more difficult to recognize when they present in an unusual location. Within the urinary tract, primary melanomas, carcinoid tumors, or epithelioid angiosarcoma could present diagnostic challenges due to their infrequent occurrence. This article emphasizes the clinical and histopathologic features of these entities and their differential diagnoses including the immunophenotype and their prognoses. Read More

Gastrointest Endosc 2018 Nov 14. Epub 2018 Nov 14.

Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Background & Aims: Prevalence of rectal carcinoids is increasing, partly due to increased colorectal cancer screening. Local excision (endoscopic or trans-anal excision) is usually performed for small (<1-2 cm) rectal carcinoids but data on clinical outcomes from large population-based U.S. Read More

Am J Cardiol 2019 Jan 27;123(1):132-138. Epub 2018 Sep 27.

Smith Clinical Outcomes Center and the Departments of Internal Medicine (Cardiovascular Division), Cardiac Surgery at the Beth Israel Deaconess Medical Center, Boston, Massachusetts.

We sought to characterize the clinical outcomes and to identify predictors of mortality undergoing isolated tricuspid valve surgery in the United States. We identified 5,164 patients undergoing isolated tricuspid valve surgery from the Centers for Medicare and Medicaid Services Medicare Provider Analysis and Review data between January 2003 and December 2014. The primary outcome was all cause 1-year mortality. Read More

Klin Onkol 2018 ;31(3):167-177

Background: Tumors arising from neuroendocrine cells are defined as epithelial neoplasms with predominantly neuroendocrine differentiation. They comprise a distinct group of tumors with a characteristic histological structure and functional properties that develop at various sites, particularly the gastrointestinal system (67%) and lungs (25%). Although such tumors are usually slow-growing and indolent, almost all have malignant potential and most can produce active hormones. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Nov;47(11):851-856

Department of Pathology, School of Basic Medicine of Qingdao University, Qingdao 266003, China.

To investigate the clinicopathologic characteristics, diagnostic features and prognosis of primary renal neuroendocrine carcinoma (NEC). The clinicopathologic data of eight cases of renal NEC was collected from January 2008 to December 2017 from Affiliated Hospital of Qingdao University. Immunohistochemical staining was performed, and follow-up information was analyzed, and the relevant literature reviewed. Read More

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

Clin Nucl Med 2019 Jan;44(1):e40-e42

From the Institute of Nuclear Medicine and Molecular Imaging, and the.

Schmorl's node (SN) arises from the herniation of the nucleus pulposus of the disc through the cartilaginous endplate into the body of the vertebra. Our report describes a patient with carcinoid tumor who underwent a series of Ga-DOTATATE PET/CT scans for follow-up, demonstrating gradually increasing focal vertebral uptake in absence of CT abnormality, suspicious for a metastasis. Both CT and MRI eventually revealed classical findings of a SN. Read More

J Thorac Dis 2018 Sep;10(9):E707-E709

Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Surgery 2019 Jan 8;165(1):158-165. Epub 2018 Nov 8.

Division of Surgical Oncology, Oregon Health & Science University, Portland. Electronic address:

Background: Sudden massive release of serotonin, histamine, kallikrein, and bradykinin is postulated to cause an intraoperative carcinoid crisis. The exact roles of each of these possible agents, however, remain unknown. Optimal treatment will require an improved understanding of the pathophysiology of the carcinoid crisis. Read More

Arch Gynecol Obstet 2018 Nov 10. Epub 2018 Nov 10.

Institute of Pathology, Klinikum Bayreuth, Preuschwitzer Strasse 101, 95445, Bayreuth, Germany.

Background: Malignant ascites often develops in patients with ovarian cancer, but there is a lack of more detailed characterization of the different histological subtypes.

Methods: Ascites specimens from patients with ovarian cancer who were treated at Bayreuth Hospital from 2006 to 2015, with follow-up until December 2016, were reevaluated retrospectively.

Results: A total of 191 women (mean age 64 years, range 48-79) were included, of whom 180 (94. Read More

J Thorac Oncol 2018 Nov 8. Epub 2018 Nov 8.

Department of Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Introduction: The TNM classification for lung cancer, originally designed for NSCLC, is applied to staging of bronchopulmonary carcinoid tumors. The validity of the eighth edition of the staging system for carcinoid tumors has not been assessed. In this study, we evaluated its prognostic accuracy by using data from a large national population-based cancer registry. Read More

J Thorac Cardiovasc Surg 2018 Oct 10. Epub 2018 Oct 10.

Division of Cardiothoracic Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Fla. Electronic address:

Oncologist 2018 Nov 9. Epub 2018 Nov 9.

Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

Background: Thymic atypical carcinoid (TAC) is a rare thymic neuroendocrine tumor that originates in the neuroendocrine system and lacks a standardized treatment. The combination of capecitabine (CAP) and temozolomide (TEM) is associated with an extremely high and long-lasting response rate in patients with metastatic pancreatic neuroendocrine tumors. However, there is little evidence showing that the CAPTEM regimen is effective for TAC. Read More

BMC Gastroenterol 2018 Nov 8;18(1):172. Epub 2018 Nov 8.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients. Read More

JOP 2018 Sep 18;19(5). Epub 2018 Sep 18.

The Department of Medicine, Tufts Medical Center, Boston MA, USA.

Background: Gastroenteropancreatic neuroendocrine tumors are neoplasms commonly found within the gastrointestinal tract that originate from endocrine cells. These are slow progressive tumors and often metastasize to other elements of the gastrointestinal tract including the liver. Consequently, these tumors release hormones including serotonin and/or histamine that are responsible for the symptoms including intermittent flushing and diarrhea. Read More

Endocr Relat Cancer 2019 Jan;26(1):119-130

Department of GI Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Immune checkpoint inhibitors have shown promising results in different cancers, and correlation between immune infiltration, expression of programmed death-ligand 1 (PD-L1) by tumor cells and response to immunotherapy has been reported. There is limited knowledge regarding the immune microenvironment of small bowel (SB) neuroendocrine tumors (NETs). This work was aimed at characterizing the immune landscape of SB NETs. Read More

J Surg Case Rep 2018 Oct 31;2018(10):rjy279. Epub 2018 Oct 31.

St. Vincent Hospital Indianapolis, Department of Hematology/Oncology, Indianapolis, IN, USA.

Cystic teratomas are rare pluripotent embryonic tumors which most commonly originate in gonadal organs. Extra-gonadal cystic teratomas are exceedingly uncommon, accounting for only 1% of all cystic teratomas, and have been reported in unusual locations including the kidney, mediastinum and liver. These extra-ovarian cystic teratomas have also been known to harbor other neoplasms including carcinoid tumors. Read More

Indian J Nucl Med 2018 Oct-Dec;33(4):359-361

Department of Nuclear Medicine, AIIMS, New Delhi, India.

J Med Genet 2018 Nov 1. Epub 2018 Nov 1.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Copa syndrome is a rare autosomal dominant disorder with abnormal intracellular vesicle trafficking. The objective of this work is to expand the knowledge about this disorder by delineating phenotypic features of an unreported COPA family.

Methods And Results: A heterozygous missense variant (c. Read More

Chirurgia (Bucur) 2018 Sept-Oct;113(5):712-718

The majority of malignant breast lesions are primary tumors originated from breast tissue. These primary breast cancers usually metastasize to lymph nodes, lungs, bones and brain. Metastases from cancers of other organs to the breast are very rare, but have been encountered in patients with malignant melanoma, carcinoid tumors or lung carcinoma. Read More

Surgery 2018 Oct 27. Epub 2018 Oct 27.

Division of Surgical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH. Electronic address:

Background: The incidence, clinical characteristics, and long-term outcomes of patients with gastroenteropancreatic neuroendrocrine tumors and carcinoid syndrome undergoing operative resection have not been well characterized.

Methods: Patients undergoing resection of primary or metastatic gastroenteropancreatic neuroendrocrine tumors between 2000 and 2016 were identified from an 8-institution collaborative database. Clinicopathologic and postoperative characteristics as well as overall survival and disease-free survival were compared among patients with and without carcinoid syndrome. Read More

Radiology 2018 Oct 30:181966. Epub 2018 Oct 30.

From the Department of Medicine, Division of Cardiology, University of Chicago-NorthShore University HealthSystem, 2680 Ridge Ave, Evanston, IL 60202 (A.A.A.); and Department of Radiology, Mayo Clinic, Jacksonville, Fla (C.A.R.).

Clin Nucl Med 2019 Jan;44(1):e57-e59

From the Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.

A 70-year-old man with a history of carcinoid tumor of small bowel was referred for Ga-DOTATOC study to evaluate the extent of disease. PET/CT scan revealed known metastatic disease in the liver, with other sites of involvement including pancreas, peritoneum, and bones. In addition, moderately intense uptake was noted in proximal right tibia and further correlation on CT showed metaphyseal lesion with "rings and arcs" calcification suggestive of enchondroma. Read More

Clin Nucl Med 2019 Jan;44(1):83-84

Department of Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. Read More

Surgery 2018 Oct 23. Epub 2018 Oct 23.

Rush University Medical Center, Department of Surgery, Chicago IL. Electronic address:

Background: Patients with gastroenteropancreatic neuroendocrine tumors often present with stage IV disease. Primary tumor resection in these patients remains controversial. Herein, we studied the impact of primary tumor removal, identified variables associated with prolonged survival for each neuroendocrine tumor subtype, and determined factors that influence surgeons to perform primary tumor resection. Read More

Int J Surg Case Rep 2018 Oct 19;53:1-4. Epub 2018 Oct 19.

Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Neuroendocrine tumors (NETs) of small intestinal origin are generally slow-growing tumors with a relatively high propensity for metastases to surrounding organs and lymphatic tissue. We present the first case of an ileal NET metastasizing to the submandibular gland in a woman with metastatic carcinoid syndrome.

Case Presentation: A 55-year-old female presented with a four-month history of a palpable, left-sided neck mass. Read More

J Cutan Pathol 2018 Oct 25. Epub 2018 Oct 25.

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, California.

Introduction: Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid-like or labyrinthine pattern can contain intratumoral Merkel cells. Read More