2,439 results match your criteria Carcinoid Gastrointestinal


Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate.

Oncotarget 2019 Jan 1;10(1):17-29. Epub 2019 Jan 1.

Department of Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Background: Neuroendocrine carcinomas of the prostate (NEPCs) are rare tumors with poor prognosis. While platinum and etoposide-based chemotherapy regimens (PE) are commonly applied in first-line for advanced disease, evidence for second-line therapy and beyond is very limited.

Methods: Retrospective analysis of all patients with NEPCs including mixed differentiation with adenocarcinoma component and well differentiated neuroendocrine tumors (NETs, carcinoids) at two high-volume oncological centers between 12/2000 and 11/2017. Read More

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http://www.oncotarget.com/fulltext/26523
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http://dx.doi.org/10.18632/oncotarget.26523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343754PMC
January 2019
1 Read

Rare case of small intestine bleeding.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Medicine, Section of Digestive Diseases, West Virginia University Hospitals, Morgantown, West Virginia, USA.

We present a case of a healthy 59-year-old woman who presented for a capsule endoscopy to evaluate melaena and iron deficiency anaemia. She had previously underwent an oesophagogastroduodenoscopy and colonoscopy at an outside institution which were unremarkable. Capsule endoscopy showed an ulcerated, bleeding lesion likely in the duodenum. Read More

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http://dx.doi.org/10.1136/bcr-2018-227184DOI Listing
January 2019
1 Read

Gastric carcinoids: Does type of surgery or tumor affect survival?

Am J Surg 2018 Dec 28. Epub 2018 Dec 28.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA. Electronic address:

Background: Gastric carcinoids are rare neuroendocrine tumors of the gastrointestinal tract. They are typically managed according to their etiology. However, there is little known about the impact of surgical strategy on the long-term outcomes of these patients. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2018.12.057DOI Listing
December 2018
1 Read

Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome.

Oncologist 2019 Jan 16. Epub 2019 Jan 16.

Lexicon Pharmaceuticals, Inc., The Woodlands, Texas, USA

Background: Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience considerable morbidity and mortality; carcinoid syndrome may be associated with shorter survival. Carcinoid syndrome is linked to tumoral secretion of serotonin and other bioactive substances. The subsequent debilitating diarrhea and urgency to defecate pose significant health risks. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0236DOI Listing
January 2019
3 Reads

Primary Carcinoid Tumor of the Testis: A Case Report and Review of the Literature.

Case Rep Urol 2018 3;2018:3614387. Epub 2018 Dec 3.

University of Balamand, Saint George Hospital University Medical Center, Department of Urology, Beirut 1100 2807, Lebanon.

Carcinoid tumors usually arise in the gastrointestinal tract. Immunocytohistochemical and radiologic studies are important in detecting the primary tumor site. Primary carcinoid tumors of the testis are particularly rare with a high malignant potential warranting long-term follow-up. Read More

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http://dx.doi.org/10.1155/2018/3614387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304607PMC
December 2018

Laparoscopic resection of a gastrointestinal stromal tumour in a Meckel's diverticulum.

J Minim Access Surg 2019 Jan 4. Epub 2019 Jan 4.

Department of General Surgery, Queen Elizabeth Hospital, Lewisham and Greenwich NHS Trust, London, England.

A Meckel's diverticulum (MD) is a congenital abnormality of the gastrointestinal tract which is estimated to be present in 2% of the population. Gastrointestinal stromal tumours (GISTs) are rare, soft-tissue tumours which represent 0.1%-3% of all gastrointestinal tumours. Read More

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http://dx.doi.org/10.4103/jmas.JMAS_239_18DOI Listing
January 2019
6 Reads

Multiple neuroendocrine tumor of the small bowel: a case report and a review of literature.

Vnitr Lek 2018 ;64(10):966-969

Primary malignant tumors of small bowel constitute only about 1-2% of all gastrointestinal neoplasms. Although neuroendocrine tumors (NETs) are relatively rare, they still represent the second most common malignancy of the small bowel (after adenocarcinoma). Clinical manifestations include abdominal pain, bowel obstruction, diarrhea, weight loss and bleeding. Read More

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January 2018
9 Reads

The safety of lanreotide for neuroendocrine tumor.

Expert Opin Drug Saf 2019 Jan 24;18(1):1-10. Epub 2018 Dec 24.

a Gastrointestinal Oncology Program and Experimental therapeutics, Division of Hematology/Oncology , Tufts Medical Center - Tufts University School of Medicine , Boston , MA , USA.

Introduction: Lanreotide autogel is a synthetic somatostatin analogue which has been FDA and EMA approved for unresectable, well to moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumor. Its action is mediated by its affinity to somatostatin receptors, especially sst2 and sst5 receptors. Its longer half-life offers the convenience of 4-week dosing over the need for frequent injections of short-acting somatostatin analogues. Read More

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https://www.tandfonline.com/doi/full/10.1080/14740338.2019.1
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http://dx.doi.org/10.1080/14740338.2019.1559294DOI Listing
January 2019
1 Read
2.911 Impact Factor

Incidence Trends of Gastroenteropancreatic Neuroendocrine Tumors in the United States.

Clin Gastroenterol Hepatol 2018 Dec 20. Epub 2018 Dec 20.

Icahn School of Medicine at Mount Sinai, Department of Gastroenterology. Electronic address:

Background & Aims: Although multiple studies have reported an increasing incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) over the past decades, there are limited national data on recent trends. Using a population-based registry, we evaluated GEP-NET incidence trends in the United States population from 1975 through 2012, based on age, calendar year at diagnosis, and year of birth.

Methods: GEP-NET cases from 1975 through 2012 were identified from the most recent version of the Surveillance, Epidemiology, and End Results registry using histologic and site codes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183139
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http://dx.doi.org/10.1016/j.cgh.2018.12.017DOI Listing
December 2018
5 Reads

Management of Typical and Atypical Pulmonary Carcinoids Based on Different Established Guidelines.

Cancers (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Division of Hematology & Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine, Buffalo, NY 14203, USA.

Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most common form of lung NETs, and other rare forms include well-differentiated typical carcinoids (TCs) and poorly differentiated atypical carcinoids (ACs). Read More

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http://www.mdpi.com/2072-6694/10/12/510
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http://dx.doi.org/10.3390/cancers10120510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315766PMC
December 2018
6 Reads

Primary Appendicular Malignancy Presenting as Abdominal Wall Abscess with Secondary Tuberculosis Infection: an Interesting Case Report.

Indian J Surg Oncol 2018 Dec 7;9(4):613-617. Epub 2018 Aug 7.

Parvarish Nursing Home, Andheri, Mumbai, Maharashtra India.

Cancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Read More

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http://dx.doi.org/10.1007/s13193-018-0804-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265167PMC
December 2018
3 Reads

Octreotide SC depot in patients with acromegaly and functioning neuroendocrine tumors: a phase 2, multicenter study.

Cancer Chemother Pharmacol 2018 Dec 8. Epub 2018 Dec 8.

Endocrinology, DiMI and CEBR, University of Genoa, Genoa, Italy.

Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety of octreotide SC depot in patients with acromegaly and functioning NETs, previously treated with octreotide IM. Read More

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http://dx.doi.org/10.1007/s00280-018-3734-1DOI Listing
December 2018
1 Read

Prevalence of Small Intestine Carcinoid Tumors: A US Population-Based Study 2012-2017.

Dig Dis Sci 2018 Dec 5. Epub 2018 Dec 5.

Division of Gastroenterology and Liver Disease, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Wearn 244, Cleveland, OH, 44106, USA.

Background And Aims: Most carcinoid tumors of the gastrointestinal tract are located in the small bowel (SB). Epidemiological studies of these tumors have been limited by small sample sizes. Our aim was to evaluate the epidemiology of SB carcinoids (SBCs) using a large database. Read More

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http://dx.doi.org/10.1007/s10620-018-5402-zDOI Listing
December 2018
1 Read

[Imaging characteristics of gastrointestinal neoplastic acute abdomen].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1223-1229

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Read More

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November 2018
1 Read

Relationship Between Symptoms and Health-related Quality-of-life Benefits in Patients With Carcinoid Syndrome: Post Hoc Analyses From TELESTAR.

Clin Ther 2018 Dec 24;40(12):2006-2020.e2. Epub 2018 Nov 24.

Dana-Farber Cancer Institute, Boston, MA, USA.

Purpose: Patients with metastatic neuroendocrine tumors and carcinoid syndrome (CS) may experience chronic, recurring symptoms despite somatostatin analogue therapy. Little is known about the relationship between bowel movement (BM) frequency, patient-reported symptoms and health-related quality of life (QoL). Data from the TELESTAR study were used in exploratory, post hoc analyses to understand the relationship between durable reductions in BM frequency, symptom relief, and health-related QoL. Read More

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http://dx.doi.org/10.1016/j.clinthera.2018.10.008DOI Listing
December 2018
4 Reads

Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid syndrome: A survey study.

Medicine (Baltimore) 2018 Nov;97(47):e13390

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.

To evaluate association of carcinoid syndrome (CS) symptom burden and somatostatin analog (SSA) duration with quality of life (QoL) using Functional Assessment of Cancer Therapy-General (FACT-G) and Patient-Reported Outcomes Measurement Information System (PROMIS-29) instruments.Adults who received treatment for CS symptoms in the US were recruited to participate in a cross-sectional online survey (July-October, 2016). Demographic, clinical, and QoL questions (FACT-G, 29 CS-related supplemental questions, PROMIS-29) were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000013390DOI Listing
November 2018
9 Reads

Histopathology of Neuroendocrine Neoplasms of the Gastrointestinal System.

Klin Onkol 2018 ;31(3):167-177

Background: Tumors arising from neuroendocrine cells are defined as epithelial neoplasms with predominantly neuroendocrine differentiation. They comprise a distinct group of tumors with a characteristic histological structure and functional properties that develop at various sites, particularly the gastrointestinal system (67%) and lungs (25%). Although such tumors are usually slow-growing and indolent, almost all have malignant potential and most can produce active hormones. Read More

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http://dx.doi.org/10.14735/amko2018167DOI Listing
January 2018
1 Read

Cutaneous Metastasis of Gastroenteropancreatic Neuroendocrine Tumors (GEP-Nets).

JOP 2018 Sep 18;19(5). Epub 2018 Sep 18.

The Department of Medicine, Tufts Medical Center, Boston MA, USA.

Background: Gastroenteropancreatic neuroendocrine tumors are neoplasms commonly found within the gastrointestinal tract that originate from endocrine cells. These are slow progressive tumors and often metastasize to other elements of the gastrointestinal tract including the liver. Consequently, these tumors release hormones including serotonin and/or histamine that are responsible for the symptoms including intermittent flushing and diarrhea. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217987PMC
September 2018
9 Reads

Influence of carcinoid syndrome on the clinical characteristics and outcomes of patients with gastroenteropancreatic neuroendocrine tumors undergoing operative resection.

Surgery 2018 Oct 27. Epub 2018 Oct 27.

Division of Surgical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH. Electronic address:

Background: The incidence, clinical characteristics, and long-term outcomes of patients with gastroenteropancreatic neuroendrocrine tumors and carcinoid syndrome undergoing operative resection have not been well characterized.

Methods: Patients undergoing resection of primary or metastatic gastroenteropancreatic neuroendrocrine tumors between 2000 and 2016 were identified from an 8-institution collaborative database. Clinicopathologic and postoperative characteristics as well as overall survival and disease-free survival were compared among patients with and without carcinoid syndrome. Read More

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http://dx.doi.org/10.1016/j.surg.2018.09.008DOI Listing
October 2018
2 Reads

Resection of primary tumor may prolong survival in metastatic gastroenteropancreatic neuroendocrine tumors.

Surgery 2018 Oct 23. Epub 2018 Oct 23.

Rush University Medical Center, Department of Surgery, Chicago IL. Electronic address:

Background: Patients with gastroenteropancreatic neuroendocrine tumors often present with stage IV disease. Primary tumor resection in these patients remains controversial. Herein, we studied the impact of primary tumor removal, identified variables associated with prolonged survival for each neuroendocrine tumor subtype, and determined factors that influence surgeons to perform primary tumor resection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183065
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http://dx.doi.org/10.1016/j.surg.2018.09.006DOI Listing
October 2018
13 Reads

Goblet cell carcinoid of the appendix. Review of the literature a propos of a rare case of endometrial metastases.

J BUON 2018 Jul-Aug;23(4):867-871

Department of Surgical Oncology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.

Background: Carcinoid tumors are rare tumors most commonly found in the gastrointestinal tract. They represent the most common malignancies of the appendix. As a distinct entity from both adenocarcinomas and carcinoids, Goblet cell carcinoid (GCC) was initially described in the literature in 1969. Read More

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October 2018
12 Reads

Five New Cases of Primary Renal Carcinoid Tumor: Case Reports and Literature Review.

Pathol Oncol Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Urology, University of Minnesota Medical School, 420 Delaware St. SE MMC 394, Minneapolis, MN, 55455, USA.

Carcinoid tumors, a slow-growing NET, most commonly arise in the gastrointestinal tract (73.7%), followed by the bronchopulmonary system (25.1%), and least commonly in the genitourinary system (<1%). Read More

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http://link.springer.com/10.1007/s12253-018-0481-x
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http://dx.doi.org/10.1007/s12253-018-0481-xDOI Listing
October 2018
9 Reads

[Asystole during surgery to manage small intestine cancer: are we dealing with anaphylaxis or carcinoid crisis].

Pan Afr Med J 2018 31;30:92. Epub 2018 May 31.

Pôle d'Anesthésie-Réanimation, Hôpital Militaire d'Instruction Mohamed V, Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Maroc.

Cardiac arrest in the operating room is a life-threatening event with multiple causes. We report the case of a 53-year old female patient with no particular past medical history scheduled for surgery to manage small intestine cancer. Twenty minutes after anesthetic induction the patient had asystole rapidly reversible after resuscitation measures. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.92.14877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191273PMC
October 2018
5 Reads

Gastroenteropancreatic Neuroendocrine Tumors.

CA Cancer J Clin 2018 Nov 8;68(6):471-487. Epub 2018 Oct 8.

Associate Professor, Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Neuroendocrine tumors (NETs) are heterogeneous malignancies arising from the diffuse neuroendocrine system. They frequently originate in the gastroenteropancreatic (GEP) tract and the bronchopulmonary tree, and their incidence has steadily increased in the last 3 decades. Fundamental biologic and genomic differences underlie the clinical heterogeneity of NETs, and distinct molecular features characterize NETs of different grades and different primary sites. Read More

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http://doi.wiley.com/10.3322/caac.21493
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http://dx.doi.org/10.3322/caac.21493DOI Listing
November 2018
4 Reads

Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms.

Endocrine 2018 Oct 2. Epub 2018 Oct 2.

1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: Our aim was to assess the prevalence of endocrine paraneoplastic syndromes (EPNS) in neuroendocrine neoplasms (NENs) and estimate its impact on patient outcomes.

Design: This is a retrospective analysis of 834 patients with NENs (611 gastrointestinal, 166 thoracic, 57 of unknown and various other primary origin). We included 719 consecutive NEN patients treated at EKPA-Laiko Hospital, Athens, Greece and 115 patients with lung carcinoid (LC) treated at Uppsala University Hospital, Uppsala, Sweden. Read More

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http://dx.doi.org/10.1007/s12020-018-1773-3DOI Listing
October 2018
14 Reads
3.530 Impact Factor

Gastric carcinoid tumor after laparoscopic gastric banding: Case report of a patient with weight regain.

Int J Surg Case Rep 2018 4;51:275-276. Epub 2018 Sep 4.

Clinical Oncology, University Hospital Interzonal General San Martín of La Plata, Buenos, Argentina.

Introduction: Although carcinoid tumours are a rare gastrointestinal neoplasm with an incidence rate of 1-2.5 cases per 100 000 inhabitants, they are the most common neuroendocrine tumour of the stomach.

Presentation Of Case: A 70-year-old-man consulted for epigastric pain and dyspepsia symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183035
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http://dx.doi.org/10.1016/j.ijscr.2018.08.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139466PMC
September 2018
14 Reads

Primary Mesenteric Carcinoid Tumor Presenting with Carcinoid Syndrome.

Case Rep Gastroenterol 2018 May-Aug;12(2):396-401. Epub 2018 Aug 21.

Digestive Disease Associates, Wyomissing, Pennsylvania, USA.

Neuroendocrine neoplasms (NENs) are a diverse group of tumors arising throughout the body with a common origin from neuroendocrine cells. Well-differentiated NENs, also known as neuroendocrine tumors (NETs), are generally indolent and are often found incidentally, while poorly differentiated tumors are more aggressive. Carcinoid tumors are NETs arising from the gastrointestinal tract and less commonly from the lungs, thymus, and kidneys. Read More

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http://dx.doi.org/10.1159/000490522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120398PMC
August 2018
17 Reads

Small Bowel and Colorectal Carcinoids.

Clin Colon Rectal Surg 2018 Sep 4;31(5):301-308. Epub 2018 Sep 4.

Division of Surgical Oncology, Department of Surgery, Oregon Health & Science University, Portland, Oregon.

Neuroendocrine tumors, or carcinoid tumors, of both the midgut and hindgut are quite rare, but their incidence is increasing. Surgery is the treatment of choice in patients who can tolerate an operation and have operable disease. Options for the treatment of metastatic disease include cytoreductive surgery, somatostatin analogues, interferon α, local liver therapies (hepatic arterial embolization, ablation), chemotherapy, Peptide-Receptor Radionucleotide Radiotherapy, angiogenesis inhibitors, and mammalian target of rapamycin inhibitors. Read More

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http://dx.doi.org/10.1055/s-0038-1642054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123011PMC
September 2018
2 Reads

A single-institution retrospective analysis of metachronous and synchronous metastatic bronchial neuroendocrine tumors.

J Thorac Dis 2018 Jul;10(7):3928-3939

Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milan, Italy.

Background: Broncho-pulmonary neuroendocrine tumors (bpNETs) are rare malignancies and there is no consensus on therapeutical management of metastatic disease and follow-up after radical resection.

Methods: Clinical records of patients with a cytological or histological diagnosis of bpNETs and distant metastases (metachronous or synchronous), evaluated at the European Institute of Oncology between 1997 and 2014, were retrospectively analyzed. Data on patient demographics, pathology, imaging exams, surgical and non-surgical treatments were collected. Read More

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http://dx.doi.org/10.21037/jtd.2018.06.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106014PMC
July 2018
9 Reads

Multimodality Imaging Review of Anorectal and Perirectal Diseases With Histological, Endoscopic, and Operative Correlation, Part I: Anatomy and Neoplasms.

Curr Probl Diagn Radiol 2018 Jul 29. Epub 2018 Jul 29.

Department of Radiology, Louisiana State University Health Shreveport, Shreveport, LA.

A broad spectrum of pathology affects the rectum, anus, and perineum and understanding of its relevant anatomy is important in accurate reporting, particularly in rectal cancer. In this pictorial essay, correlative imaging, endoscopic, pathologic, and operative images are presented to illustrate normal anorectal anatomy and neoplastic conditions that affect the anus and rectum. A particular case-based focus is given to rectal adenocarcinoma with pelvic MR and surgical histopathology. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.07.015DOI Listing
July 2018
15 Reads

Uveal Metastasis: Clinical Features and Survival Outcome of 2214 Tumors in 1111 Patients Based on Primary Tumor Origin.

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):81-90

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site.

Methods: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site.

Results: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_6_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071342PMC
September 2018
6 Reads

The Evolving Treatment Algorithm for Advanced Neuroendocrine Neoplasms: Diversity and Commonalities Across Tumor Types.

Oncologist 2019 Jan 13;24(1):54-61. Epub 2018 Aug 13.

H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

Neuroendocrine neoplasms (NEN) most commonly arise in the gastroenteropancreatic system and lungs. The incidence of NEN is increasing globally, with improved diagnostic techniques identifying patients with early-stage disease. The number of approved therapies for the treatment of advanced disease has grown substantially in the past decade. Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324634PMC
January 2019
20 Reads

Telotristat ethyl for the treatment of carcinoid syndrome diarrhea not controlled by somatostatin analogues.

Authors:
P M Kasi

Drugs Today (Barc) 2018 Jul;54(7):423-432

College of Medicine and Oncology, Division of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA.

Telotristat ethyl (Xermelo), developed by Lexicon Pharmaceuticals, is an oral tryptophan hydroxylase inhibitor blocking peripheral conversion of tryptophan to serotonin (5-hydroxytryptamine [5-HT]). It was approved by the U.S. Read More

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http://dx.doi.org/10.1358/dot.2018.54.7.2834460DOI Listing
July 2018
1 Read

Malignancy and Meckel's diverticulum: A systematic literature review and 14-year experience at a tertiary referral center.

United European Gastroenterol J 2018 Jun 16;6(5):739-747. Epub 2018 Jan 16.

Division of Colorectal Surgery, Mayo Clinic, Rochester, USA.

Background: Meckel's diverticulum is present in about 2% of the population. The literature reports 3.2% incidence of tumors within Meckel's diverticulum; the tumors are predominantly benign. Read More

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http://dx.doi.org/10.1177/2050640617752771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068795PMC
June 2018
14 Reads

Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors.

Int J Endocrinol 2018 2;2018:8126087. Epub 2018 Jul 2.

Endocrinological Oncology, Service of Endocrinology, A.O. San Camillo-Forlanini, Rome, Italy.

. Neuroendocrine tumors (NETs) are characterized by having behavior and prognosis that depend upon tumor histology, primary site, staging, and proliferative index. The symptoms associated with carcinoid syndrome and vasoactive intestinal peptide tumors are treated with octreotide acetate. Read More

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http://dx.doi.org/10.1155/2018/8126087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051263PMC
July 2018
3 Reads

Endoscopic ultrasound FNA: An illustrated review of spindle cell neoplasms of the upper gastrointestinal tract including a novel case of gastric plexiform fibromyxoma.

Diagn Cytopathol 2018 Sep 25;46(9):730-738. Epub 2018 Jul 25.

Department of Pathology, Cleveland Clinic, Cleveland, Ohio.

Plexiform fibromyxoma (PF) is a recently-described and rare mesenchymal neoplasm of the gastric wall. A few small case series reports of this spindle cell entity exist in the surgical pathology literature, but to our knowledge no prior endoscopic ultrasound guided fine needle aspiration cytology examples have been reported. In clinical practice, mural gastrointestinal (GI) lesions are often initially evaluated by endoscopic ultrasound guided (EUS) fine needle aspiration (FNA). Read More

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http://doi.wiley.com/10.1002/dc.24040
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http://dx.doi.org/10.1002/dc.24040DOI Listing
September 2018
13 Reads

Efficacy and Safety of Sunitinib in Patients with Well-Differentiated Pancreatic Neuroendocrine Tumours.

Neuroendocrinology 2018 10;107(3):237-245. Epub 2018 Jul 10.

Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, Milan,

Background: In a phase III study, sunitinib led to a significant increase in progression-free survival (PFS) versus placebo in patients with pancreatic neuroendocrine tumours (panNETs). This study was a post-marketing commitment to support the phase III data.

Methods: In this ongoing, open-label, phase IV trial (NCT01525550), patients with progressive, advanced unresectable/metastatic, well-differentiated panNETs received continuous sunitinib 37. Read More

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https://www.karger.com/Article/FullText/491999
Publisher Site
http://dx.doi.org/10.1159/000491999DOI Listing
January 2019
13 Reads
4.373 Impact Factor

Telotristat Ethyl: A Review in Carcinoid Syndrome Diarrhoea.

Drugs 2018 Jun;78(9):941-950

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Telotristat ethyl (Xermelo), a first-in-class peripheral tryptophan hydroxylase (TPH) inhibitor, is approved to treat carcinoid syndrome diarrhoea in combination with somatostatin analogue (SSA) therapy in adults inadequately controlled by SSA therapy alone. Some neuroendocrine tumours secrete serotonin (5-HT) into the blood, resulting in frequent bowel movements (BMs) and other symptoms. Telotristat ethyl inhibits TPH, thereby reducing the production of 5-HT and improving carcinoid syndrome diarrhoea. Read More

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http://dx.doi.org/10.1007/s40265-018-0935-1DOI Listing
June 2018
2 Reads

Outcomes of Surgical and Chemotherapeutic Treatments of Goblet Cell Carcinoid Tumors of the Appendix.

Ann Surg Oncol 2018 Aug 18;25(8):2391-2399. Epub 2018 Jun 18.

Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.

Background: Goblet cell carcinoids (GCCs) of the appendix are rare mucinous neoplasms, for which optimal therapy is poorly described. We examined prognostic clinical and treatment factors in a population-based cohort.

Methods: Patients diagnosed with GCC from 1984 to 2014 were identified from the British Columbia Cancer Agency and the Vancouver Lower Mainland Pathology Archive. Read More

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http://dx.doi.org/10.1245/s10434-018-6560-0DOI Listing
August 2018
3 Reads

Advanced typical and atypical carcinoid tumours of the lung: management recommendations.

Authors:
B Melosky

Curr Oncol 2018 Jun 13;25(Suppl 1):S86-S93. Epub 2018 Jun 13.

Medical Oncology, BC Cancer-Vancouver Centre, BC.

Background: Neuroendocrine tumours (nets) are classified by site of origin, with lung being the second most common primary site after the gastrointestinal tract. Lung nets are rare and heterogeneous, with varied pathologic and clinical features. Typical and atypical carcinoid tumours are low-grade lung nets which, compared with the more common high-grade nets, are associated with a more favourable prognosis. Read More

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http://dx.doi.org/10.3747/co.25.3808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001761PMC

[Oligometastases of neuroendocrine tumors-extent of surgery].

Chirurg 2018 Jun 6. Epub 2018 Jun 6.

Klinik für Allgemein-, Viszeral-, und Transplantationschirurgie, Klinikum der Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland.

Neuroendocrine tumors (NETs) are rare neoplasms, which represent complex challenges in diagnosis and treatment. Even in the metastatic stage there are important differences in the type of tumor in comparison to gastrointestinal and pancreatic adenocarcinomas. Therefore, the disease courses are substantially different depending on the grade of differentiation. Read More

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http://dx.doi.org/10.1007/s00104-018-0644-zDOI Listing
June 2018
22 Reads

Primary Renal Carcinoid - A Case Report.

Ir Med J 2018 Jan 10;111(1):677. Epub 2018 Jan 10.

Adelaide and Meath National Children's Hospital.

Carcinoid tumours in the abdomen are uncommon, but typically occur in the gastrointestinal tract. Primary renal carcinoid is an extremely rare tumour, poorly described in the literature. We describe an unusual case where an atypical renal mass on imaging led to a preoperative diagnosis of renal carcinoid on imaging guiding biopsy. Read More

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January 2018

Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix: 2018 Update.

Clin Lab Med 2018 06;38(2):343-355

Department of Pathology, Harper University Hospital, Detroit Medical Center, 3990 John R Street, Detroit, MI 48201, USA.

Neoplasms of the small intestine are rare in comparison with colorectal tumors. The most common tumor types arising in the small intestine are adenocarcinomas, well-differentiated neuroendocrine tumors, gastrointestinal stromal tumors, and lymphoma. Primary appendiceal neoplasms are rare and found in less than 2% of appendectomy specimens with an incidence of approximately 1. Read More

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http://dx.doi.org/10.1016/j.cll.2018.03.002DOI Listing
June 2018
7 Reads

[Prognostic analysis and clinicopathological features of 20 patients with appendiceal neuroendocrine neoplasms].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 May;21(5):564-568

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Objective: To investigate clinicopathological features and prognostic factors of appendiceal neuroendocrine neoplasms(a-NEN).

Methods: Clinical data of 20 patients diagnosed with a-NEN at Zhongshan Hospital of Fudan University between January 2000 and December 2016 were retrospectively analyzed. Pathological diagnosis was based on the WHO classification criteria of digestive system tumors (2010 edition). Read More

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May 2018
13 Reads

Extranodal Rosai-Dorfman Disease With Mucosal Involvement of the Stomach in a Background of Autoimmune Atrophic Gastritis.

Int J Surg Pathol 2018 Oct 2;26(7):671-675. Epub 2018 May 2.

1 Northwestern Memorial Hospital, Chicago, IL, USA.

Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, has been described involving both lymph nodes and extranodal sites, but extranodal RDD rarely involves the gastrointestinal tract. Although the etiology is unclear, several risk factors have been shown to be highly associated with this disease process, including viral infection and immune alterations. In this article, we present a case of a 79-year-old male with a history of autoimmune atrophic gastritis and multiple carcinoid tumors of the stomach presenting with a new stomach mass. Read More

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http://dx.doi.org/10.1177/1066896918773399DOI Listing
October 2018
7 Reads

Neuroendocrine Neoplasia in Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) of the Lung: A Case Report and Immunohistochemistry Analysis of Eight Pulmonary MALT Lymphomas.

Int J Surg Pathol 2018 Oct 19;26(7):660-663. Epub 2018 Apr 19.

1 Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA.

Carcinoid tumorlets are peribronchiolar proliferations of neuroendocrine cells often associated with lung scars. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a non-Hodgkin's lymphoma that frequently involves the gastrointestinal tract but less commonly is described in the lung. Simultaneous occurrence of neuroendocrine neoplasms and MALT lymphoma is extraordinarily rare and has predominately been reported in the gastrointestinal tract. Read More

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http://journals.sagepub.com/doi/10.1177/1066896918769745
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http://dx.doi.org/10.1177/1066896918769745DOI Listing
October 2018
11 Reads

Flushing Disorders Associated with Gastrointestinal Symptoms: Part 1, Neuroendocrine Tumors, Mast Cell Disorders and Hyperbasophila.

Clin Med Res 2018 Jun 12;16(1-2):16-28. Epub 2018 Apr 12.

University of Central Florida College of Medicine/HCA Consortium Graduate Medical Education, North Florida Regional Medical Center, 6500 W Newberry Rd, Gainesville, FL 32605.

Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands. Read More

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http://dx.doi.org/10.3121/cmr.2017.1379aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108509PMC
June 2018
7 Reads

Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element.

Int J Gynecol Pathol 2018 Apr 3. Epub 2018 Apr 3.

Department of Diagnostic Pathology, Anjo Kosei Hospital, Anjo-cho, Anjo, Aichi, Japan.

Sertoli-Leydig cell tumors are a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and sometimes heterologous elements. We describe the case of a 68-yr-old woman who presented with abdominal distention. A computed tomographic scan revealed a large right adnexal mass without evidence of intrahepatic tumors, and a complete cytoreductive surgery was performed. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000499DOI Listing
April 2018
14 Reads

Cinematic rendering of small bowel pathology: preliminary observations from this novel 3D CT visualization method.

Abdom Radiol (NY) 2018 Nov;43(11):2928-2937

The Russell H. Morgan Department of Radiology and Radiological Science, The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, 601 N. Caroline St, Baltimore, MD, 21287, USA.

3D visualization methods for volumetric CT data have played an important role in diagnostic imaging of the small bowel, a structure which intrinsically crosses numerous slices in any 2D imaging plane. Recently, a new approach to 3D CT image creation has become available-cinematic rendering (CR). CR differs from other 3D methods in making use of a global lighting model that produces high surface detail and realistic shadowing effects that lead to 3D visualizations with photorealistic quality. Read More

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http://dx.doi.org/10.1007/s00261-018-1578-0DOI Listing
November 2018
2 Reads