12,344 results match your criteria Carcinogenesis[Journal]


Cripto-1 promotes tumor invasion and predicts poor outcomes in hepatocellular carcinoma.

Carcinogenesis 2020 Jul;41(5):571-581

Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Cripto-1 (CR1), an oncofetal protein, had been implied to reactivate in some cancers. However, the relationship between CR1 expression and patient outcomes and the tumor biological function of CR1 contributing to invasion and metastasis in hepatocellular carcinoma (HCC) is poorly defined. In this study, we demonstrated that CR1 was expressed in over 80% of HCCs in a training cohort (n = 242) and a validation cohort (n = 159). Read More

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http://dx.doi.org/10.1093/carcin/bgz133DOI Listing

GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.

Carcinogenesis 2020 Jul 10. Epub 2020 Jul 10.

Department of Anatomy, Inje University College of Medicine, Busan, Republic of Korea.

In cancer, resistance to chemotherapy is one of the main reasons for therapeutic failure. Cells that survive after treatment with anticancer drugs undergo various changes, including in cell metabolism. In this study, we investigated the effects of AKT-mediated miR-125b-5p alteration on metabolic changes and examined how these molecules enhance migration and induce drug resistance in colon cancer cells. Read More

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http://dx.doi.org/10.1093/carcin/bgaa074DOI Listing

Cripto-1 promotes tumor invasion and predicts poor outcomes in hepatocellular carcinoma.

Carcinogenesis 2020 Jul;41(5):571-581

Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Cripto-1 (CR1), an oncofetal protein, had been implied to reactivate in some cancers. However, the relationship between CR1 expression and patient outcomes and the tumor biological function of CR1 contributing to invasion and metastasis in hepatocellular carcinoma (HCC) is poorly defined. In this study, we demonstrated that CR1 was expressed in over 80% of HCCs in a training cohort (n = 242) and a validation cohort (n = 159). Read More

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http://dx.doi.org/10.1093/carcin/bgz133DOI Listing

Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway.

Carcinogenesis 2020 Jul 6. Epub 2020 Jul 6.

Department of Biological Sciences, Orta Dogu Teknik Universitesi, Ankara, Turkey.

AKR1B1 and AKR1B10, members of the aldo-keto reductase family of enzymes that participate in the polyol pathway of aldehyde metabolism, are aberrantly expressed in colon cancer. We previously showed that high expression of AKR1B1 (AKR1B1HIGH) was associated with enhanced motility, inflammation and poor clinical outcome in colon cancer patients. Using publicly available datasets and ex vivo gene expression analysis (n=51, Ankara cohort), we have validated our previous in silico finding that AKR1B1HIGH was associated with worse overall survival (OS) compared to patients with low expression of AKR1B1 (AKR1B1LOW) samples. Read More

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http://dx.doi.org/10.1093/carcin/bgaa072DOI Listing

Oral microbial dysbiosis and its performance in predicting oral cancer.

Carcinogenesis 2020 Jul 4. Epub 2020 Jul 4.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To characterize the disturbances in the oral microbial population mainly due to oral tumorigenicity, we profiled the bacteria within the surface of OSCC lesion and its contralateral normal tissue from discovery (n=74) and validation (n=42) cohorts of male patients with cancers of the buccal mucosa. Read More

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http://dx.doi.org/10.1093/carcin/bgaa062DOI Listing

EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2.

Carcinogenesis 2020 Jul;41(6):863-864

Hunan Provincial Cancer Hospital and Cancer Hospital Affiliated to Xiangya Medical School, Central South University, Changsha, Hunan.

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http://dx.doi.org/10.1093/carcin/bgaa023DOI Listing

Targeting Cellular Senescence in Cancer and Aging: Roles of p53 and its Isoforms.

Carcinogenesis 2020 Jul 3. Epub 2020 Jul 3.

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Cellular senescence and the associated secretory phenotype (SASP) promote disease in the aged population. Targeting senescent cells by means of removal, modulation of SASP, or through cellular reprogramming, represents a novel therapeutic avenue for treating cancer- and age-related diseases such as neurodegeneration, pulmonary fibrosis, and renal disease. Cellular senescence is partly regulated by the TP53 gene, a critical tumor suppressor gene which encodes 12 or more p53 protein isoforms. Read More

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http://dx.doi.org/10.1093/carcin/bgaa071DOI Listing

The interplay of GDF15 (growth differentiation factor 15) expression and M2 macrophages during prostate carcinogenesis.

Carcinogenesis 2020 Jul 2. Epub 2020 Jul 2.

Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI.

M2 (tumor-supportive) macrophages may upregulate GDF15 (growth/differentiation factor 15), which is highly expressed in prostate tumors, but the combined utility of these markers as prognostic biomarkers are unclear. We retrospectively studied 90 prostate cancer cases that underwent radical prostatectomy as their primary treatment and were followed for biochemical recurrence (BCR). These cases also had a benign prostate biopsy at least one year or more before their prostate cancer surgery. Read More

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http://dx.doi.org/10.1093/carcin/bgaa065DOI Listing

Genetic variants in the human leukocyte antigen region and survival of Chinese patients with non-small-cell lung carcinoma.

Carcinogenesis 2020 Jul 2. Epub 2020 Jul 2.

Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Shanghai, China.

Human leukocyte antigen (HLA) is highly polymorphic, driving antigen presentation, complement cascade, and leukocyte maturation against cancer cells. Therefore, we extracted genotyping data in the HLA region from an ongoing Chinese genome-wide association study of non-small cell lung cancer (NSCLC). Using deep sequencing data of 10,689 healthy Han Chinese, we imputed the HLA region, followed by a two-stage survival analysis of 1,531 NSCLC patients. Read More

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http://dx.doi.org/10.1093/carcin/bgaa066DOI Listing

Leukocyte telomere length is associated with aggressive prostate cancer in localized African American prostate cancer patients.

Carcinogenesis 2020 Jul 2. Epub 2020 Jul 2.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Telomeres play important roles in cancer initiation and progression. Leukocyte telomere length (LTL) has been associated with the risk and prognosis of several cancers, but its association with prostate cancer (PCa) prognosis in African Americans has not been reported. In this study, we measured relative LTL from 317 African American PCa patients and assessed its associations with aggressive disease characteristics at diagnosis and biochemical recurrence (BCR) after radical prostatectomy and radiotherapy. Read More

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http://dx.doi.org/10.1093/carcin/bgaa070DOI Listing

Increased Arginase1 expression in tumor microenvironment promotes mammary carcinogenesis via multiple mechanisms.

Carcinogenesis 2020 Jul 2. Epub 2020 Jul 2.

IRCCS Ospedale Policlinico San Martino, L.go Rosanna Benzi, Genova, Italy.

Arginine metabolism plays a significant role in regulating cell function, affecting tumor growth and metastatization. To study the effect of the arginine-catabolizing enzyme arginase 1 (ARG1) on tumor microenvironment, we generated a mouse model of mammary carcinogenesis by crossbreeding a transgenic mouse line overexpressing ARG1 in macrophages (FVBArg+/+) with the MMTV-Neu mouse line (FVBNeu+/+). This double transgenic line (FVBArg+/-;Neu+/+) showed a significant shortening in mammary tumor latency, and an increase in the number of mammary nodules. Read More

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http://dx.doi.org/10.1093/carcin/bgaa063DOI Listing

NF-κB-miR-155 axis activation mediates ovulation-induced oncogenic effects in fallopian tube epithelium.

Carcinogenesis 2020 Jul 2. Epub 2020 Jul 2.

Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel.

The fallopian tube secretory epithelial cells (FTSECs) are the cell-of-origin of most high grade serous ovarian carcinomas (HGSOC). FTSECs are repeatedly exposed to inflammation induced by follicular fluid (FF) that is released with every ovulation cycle throughout a woman's reproductive years. Uninterrupted ovulation cycles are an established risk factor for HGSOC. Read More

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http://dx.doi.org/10.1093/carcin/bgaa068DOI Listing

Interplay between Estrogen and Stat3/NF-κB Driven Immunomodulation in Lung Cancer.

Carcinogenesis 2020 Jun 30. Epub 2020 Jun 30.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

K-ras mutant lung adenocarcinoma (LUAD) is the most common type of lung cancer, displays abysmal prognosis, and is tightly linked to tumor-promoting inflammation, which is increasingly recognized as a target for therapeutic intervention. We have recently shown a gender-specific role for epithelial Stat3 signaling in the pathogenesis of K-ras mutant LUAD. Absence of epithelial Stat3 in male K-ras mutant mice (LR/Stat3Δ/Δ mice) promoted tumorigenesis and induced an NF-κB driven pro-tumor immune response while reducing tumorigenesis and enhancing anti-tumor immunity in female counterparts. Read More

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http://dx.doi.org/10.1093/carcin/bgaa064DOI Listing

Modulation of the PD-1/PD-L1 immune checkpoint axis during inflammation-associated lung tumorigenesis.

Carcinogenesis 2020 Jun 30. Epub 2020 Jun 30.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.

Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the status of immune cells and immune checkpoint proteins in lung tumors induced by the tobacco smoke carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) or NNK + lipopolysaccharide (LPS), a model for COPD-associated lung tumors. Read More

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http://dx.doi.org/10.1093/carcin/bgaa059DOI Listing

Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer.

Carcinogenesis 2020 Jun 18. Epub 2020 Jun 18.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

DNA repair genes are commonly altered in metastatic prostate cancer, but BRCA1 mutations are rare. Preliminary studies suggest that higher tumor expression of the BRCA1 protein may be associated with worse prognosis. We undertook a prospective study among men with prostate cancer in the Health Professionals Follow-up Study and evaluated BRCA1 via immunohistochemical staining on tissue microarrays. Read More

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http://dx.doi.org/10.1093/carcin/bgaa061DOI Listing

Adipokines expression and epithelial cell polarity in normal and cancerous breast tissue.

Carcinogenesis 2020 Jun 17. Epub 2020 Jun 17.

Laboratory of Medical Statistics and Biometry, 'Giulio A. Maccacaro', Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, Italy.

Cell polarity is crucial for the correct structural and functional organization of epithelial tissue. Its disruption can lead to loss of the apicobasal polarity, alteration in the intracellular components, misregulation of the pathways involved in cell proliferation and cancer promotion. Very recent in vitro/in vivo findings demonstrated that obesity-associated alterations in tissue adipokines protein level negatively affect epithelial polarity. Read More

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http://dx.doi.org/10.1093/carcin/bgaa060DOI Listing

DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.

Carcinogenesis 2020 Jun 12. Epub 2020 Jun 12.

The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital, Shijiazhuang, China.

Dual oxidase 2 (DUOX2) is an important regulatory protein in the organic process of thyroid hormone iodine. Mounting evidence suggests that DUOX2 plays a crucial role in the occurrence and development of cancers. However, the function and mechanism of DUOX2 in colorectal cancer (CRC) has not been fully clarified. Read More

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http://dx.doi.org/10.1093/carcin/bgaa056DOI Listing
June 2020
5.334 Impact Factor

A novel regulatory loop miR-101/ANXA2/EGR1 mediates malignant characteristics of liver cancer stem cells.

Carcinogenesis 2020 Jun 12. Epub 2020 Jun 12.

Department of Pharmacy. The Affiliated Infectious Diseases Hospital of Soochow University, The Fifth People's Hospital of Suzhou, Suzhou, China.

Increasing evidence suggests that liver cancer stem cells (LCSCs) are the cellular determinants that promote tumor recurrence and metastases. Aberrantly expressed miRNAs were identified in LCSCs and found to play a significant role in modulating biological characteristics of LCSCs. In this study, we implemented miRNA microarrays in CD133+ LCSCs and found miR-101 expression was down-regulated. Read More

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http://dx.doi.org/10.1093/carcin/bgaa055DOI Listing

Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+ T cells against esophageal carcinoma.

Carcinogenesis 2020 Jun 12. Epub 2020 Jun 12.

Department of Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.

Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA that is frequently expressed in esophageal cancer and is correlated with a poor esophageal cancer prognosis. Consequently, MAGE-A11 is a potential immunotherapy target. Read More

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http://dx.doi.org/10.1093/carcin/bgaa057DOI Listing

IL-23R in laryngeal cancer: a cancer immunoediting process that facilitates tumor cell proliferation and results in cisplatin resistance.

Carcinogenesis 2020 Jun 12. Epub 2020 Jun 12.

Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Oncogenic pathogens can disturb tissue homeostasis and initiate immune responses for oncogenicity clearance and homeostasis restoration, while failed clearance and chronic inflammation may result in tumorigenesis. The primary tumor development will undergo a cancer immunoediting process, including three phases, termed elimination, equilibrium, and escape. Importantly, immune-edited tumor cells can not only reduce immunogenic molecular expression but also manipulate cytokines within the tumor environment (TME) for immune evasion and tumor proliferation. Read More

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http://dx.doi.org/10.1093/carcin/bgaa058DOI Listing

Aspartate β-hydroxylase targeting in castration resistant prostate cancer modulates the NOTCH/ HIF1α/GSK3β crosstalk.

Carcinogenesis 2020 Jun 11. Epub 2020 Jun 11.

Molecular Oncology & Angiogenesis,IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Castration-resistant prostate cancer (CRPC) is an incurable stage of the disease. A multivariate principal component analysis on CRPC in vitro models identified aspartyl (asparaginyl) β hydrolase (ASPH) as the most relevant molecule associated with the CRPC phenotype. ASPH is overexpressed in various malignant neoplasms and catalyzes the hydroxylation of aspartyl and asparaginyl residues in the epidermal growth factor (EGF)-like domains of proteins like NOTCH receptors and ligands, enhancing cell motility, invasion and metastatic spread. Read More

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http://dx.doi.org/10.1093/carcin/bgaa053DOI Listing

Differences in gene-expression profiles in breast cancer between African and European-ancestry women.

Carcinogenesis 2020 Jun 8. Epub 2020 Jun 8.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center.

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http://dx.doi.org/10.1093/carcin/bgaa041DOI Listing

Glioma-derived extracellular vesicles promote tumor progression by conveying WT1.

Carcinogenesis 2020 May 28. Epub 2020 May 28.

Department of Immunology, Kanazawa University Graduate School of Medical Sciences, Takara, Kanazawa, Ishikawa, Japan.

Glioma persists as one of the most aggressive primary tumors of the central nervous system. Glioma cells are known to communicate with tumor-associated macrophages/microglia via various cytokines to establish the tumor microenvironment. However, how extracellular vesicles (EVs), emerging regulators of cell-cell communication networks, function in this process is still elusive. Read More

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http://dx.doi.org/10.1093/carcin/bgaa052DOI Listing

LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes.

Carcinogenesis 2020 May 27. Epub 2020 May 27.

School of Public Health, Shenzhen University Health Science Center, Shenzhen, China.

Increasing evidence suggest that long non-coding RNAs (lncRNAs) play critical roles in cancers. However, the expression pattern and underlying mechanisms of lncRNAs in non-small cell lung cancer (NSCLC) remain incompletely understood. In this study, lncRNA microarray was performed to identify differential expressed lncRNAs between pre- and post-operation plasma in NSCLC patients. Read More

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http://dx.doi.org/10.1093/carcin/bgaa051DOI Listing

3,3-Diindolylmethane (DIM): A nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial.

Carcinogenesis 2020 May 27. Epub 2020 May 27.

Division of Urology, Rabin Medical Center -- Beilinson Campus, Petach Tikva, Israel.

Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol (I3C) found in cruciferous vegetables, can potentially prevent carcinogenesis and tumor development. The primary aim of this prospective single-arm study was to investigate the effect of DIM supplementation on breast density, a recognized predictive factor of breast-cancer risk. Read More

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http://dx.doi.org/10.1093/carcin/bgaa050DOI Listing

Lenvatinib suppresses cancer stem-like cells in HCC by inhibiting FGFR 1-3 signaling, but not FGFR4 signaling.

Carcinogenesis 2020 May 25. Epub 2020 May 25.

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

In hepatocellular carcinoma (HCC), a subset of cells defined by high CD44 and CD133 expression has been reported to possess cancer stem-like cell (CSC) characteristics and to be associated with a poor prognosis. Since the approval of the multi-kinase inhibitor, lenvatinib, for patients with unresectable HCC, two such inhibitors (sorafenib and lenvatinib) have been employed as first-line systemic chemotherapeutics for these patients. Based on differences in the kinase-affinity profiles between these two drugs, evidence has suggested that both exert different effects on HCC, although these differences are not fully characterized. Read More

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http://dx.doi.org/10.1093/carcin/bgaa049DOI Listing

Familial Adenomatous Polyposis in Dogs: Hereditary Gastrointestinal Polyposis in Jack Russell Terriers with Germline APC Mutations.

Carcinogenesis 2020 May 23. Epub 2020 May 23.

Laboratory of Veterinary Pathology, Gifu University, Yanagido, Gifu, Japan.

Many hereditary disorders in dogs have equivalents in humans and thus attract attention as natural animal models. Breed predisposition to certain diseases often provides promising clues to explore novel hereditary disorders in dogs. Recently, cases of gastrointestinal (GI) polyps in Jack Russell Terriers (JRTs) have increased in Japan. Read More

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http://dx.doi.org/10.1093/carcin/bgaa045DOI Listing

Targeting RLIP with CRISPR/Cas9 controls tumor growth.

Carcinogenesis 2020 May 19. Epub 2020 May 19.

Department of Medical Oncology, City of Hope Comprehensive Cancer Center and National Medical Center, Duarte, CA.

Breast cancer (BC) remains one of the major causes of cancer deaths in women. Over half of all BCs carry genetic defects in the gene encoding p53, a powerful tumor suppressor. P53 is known as the "guardian of the genome" because it is essential for regulating cell division and preventing tumor formation. Read More

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http://dx.doi.org/10.1093/carcin/bgaa048DOI Listing

The use of miRNA in the early detection of cervical intraepithelial neoplasia.

Carcinogenesis 2020 May 17. Epub 2020 May 17.

Department of Obstetrics and Gynecology, University Hospital RWTH, Aachen, Germany.

An important issue in current oncological research is the prevention as well as early detection of cancer. This includes also the difficulty to predict progression of early or pre-cancerous lesions to invasive cancer. In this context, the characterization and categorization of pre-neoplastic lesions of squamous cell carcinoma (cervical intraepithelial neoplasia =CIN) is an important task with major clinical impact. Read More

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http://dx.doi.org/10.1093/carcin/bgaa046DOI Listing

MicroRNA-135a-induced formation of CD133+ subpopulation with cancer stem cell properties in cervical cancer.

Carcinogenesis 2020 May 16. Epub 2020 May 16.

Shenzhen Key Laboratory of Fertility Regulation, Shenzhen, People's Republic of China.

Cancer stem cells (CSCs) play significant roles in tumor initiation. MicroRNA-135a (miR-135a) induced the formation of a CD133+ subpopulation from a human papillomavirus-immortalized cervical epithelial cell line. Compared with the CD133- cells, the CD133+ cells expressed higher levels of miR-135a and OCT4, exhibited significantly higher tumorsphere forming capacity and the time required for tumorsphere formation was shortened in the second generation. Read More

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http://dx.doi.org/10.1093/carcin/bgaa025DOI Listing

Response to letter to the editor of Carcinogenesis by Li et al., 2020.

Carcinogenesis 2020 Jun;41(4):539-540

Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece.

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http://dx.doi.org/10.1093/carcin/bgaa042DOI Listing
June 2020
5.334 Impact Factor

Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.

Carcinogenesis 2020 May 11. Epub 2020 May 11.

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Liver cancer is a major threat to human life and health, and chemotherapy has been the standard non-surgical treatment for liver cancer. However, the emergence of drug resistance of liver cancer cells has hindered the therapeutic effect of chemical drugs. The discovery of exosomes has provided new insights into the mechanisms underlying tumour cell resistance. Read More

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http://dx.doi.org/10.1093/carcin/bgaa029DOI Listing

E2F5 promotes prostate cancer cell migration and invasion through regulation of TFPI2, MMP-2 and MMP-9.

Carcinogenesis 2020 May 9. Epub 2020 May 9.

Department of Biochemistry, University of Calcutta, Kolkata, West Bengal, India.

Previously, our laboratory demonstrated that a deregulated E2F5/p38/SMAD3 axis was associated with uncontrolled cellular proliferation in prostate cancer (PCa). Here we investigate the role of E2F5 in PCa in further details. RNAi-mediated E2F5 knockdown and pathway-focused gene expression profiling in PC3 cells identified TFPI2 as a downstream target of E2F5. Read More

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http://dx.doi.org/10.1093/carcin/bgaa043DOI Listing
May 2020
5.334 Impact Factor

NRF2 as a regulator of cell metabolism and inflammation in cancer.

Carcinogenesis 2020 Jun;41(4):405-416

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, San Diego, La Jolla, CA, USA.

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcriptional regulator of genes whose products defend our cells for toxic and oxidative insults. Although NRF2 activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that disrupt the negative control of NRF2 activity or other factors. Importantly, NRF2 activation is associated with poor prognosis and NRF2 has turned out to be a key activator of cancer-supportive anabolic metabolism. Read More

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http://dx.doi.org/10.1093/carcin/bgaa039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298623PMC

TUSC3 induces drug resistance and cellular stemness via Hedgehog signaling pathway in colorectal cancer.

Carcinogenesis 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, PR China.

Tumor suppressor candidate 3 (TUSC3) is a coding gene responsible for N-glycosylation of many critical proteins. TUSC3 gene plays an oncogenic role in colorectal cancer (CRC), however, the role of TUSC3 in drug resistance of CRC is still unclear. The aim of this study is to investigate the biological function and molecular mechanism of TUSC3 in CRC drug resistance. Read More

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http://dx.doi.org/10.1093/carcin/bgaa038DOI Listing

TNFα signalling predicts poor prognosis of patients with endometrial cancer.

Carcinogenesis 2020 Apr 6. Epub 2020 Apr 6.

Department of Obstetrics and Gynaecology, Medical University of Innsbruck, Anichstraße, Innsbruck, Austria.

Endometrial cancer (EC) is the most common gynaecologic tumour in the Western world. Previous studies have implicated an imbalance of oestrogens and progestogens in the development of most ECs, while the role of low-grade tissue inflammation remains largely unexplored. We investigated the impact of tumour necrosis factor alpha (TNFα), a central mediator of inflammation, and spermatogenesis-associated protein 2 (SPATA2), a regulator of TNF receptor signalling, on clinical outcomes in EC. Read More

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http://dx.doi.org/10.1093/carcin/bgaa034DOI Listing

Genotype-immunophenotype analysis reveals the immunogenomic subtype and prognosis of multiple myeloma.

Carcinogenesis 2020 Apr 11. Epub 2020 Apr 11.

Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.

Immune dysfunction plays an important role in tumour development, recurrence, therapeutic responses and overall survival. Multiple myeloma (MM) is a clonal B-cell malignancy which characterized by antitumoural immune dysfunction. In this study, we analyzed 28 tumour-immune-related pathways and calculated the immune pathway score through published microarray data from the Gene Expression Omnibus (GEO) data portal. Read More

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http://dx.doi.org/10.1093/carcin/bgaa037DOI Listing

Differences in Gene-Expression Profiles in Breast Cancer between African and European-ancestry Women.

Carcinogenesis 2020 Apr 8. Epub 2020 Apr 8.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

African American (AA) women have an excess breast cancer mortality than European American (EA) women. To investigate the contribution of tumor biology to this survival health disparity, we compared gene expression profiles in breast tumors using RNA sequencing data derived from 260 AA and 155 EA women who were prospectively enrolled into the Southern Community Cohort Study (SCCS) and developed breast cancer during follow-up. We identified 59 genes (54 protein-coding genes and 5 long intergenic non-coding RNAs) that were expressed differently between EA and AA at a stringent false discovery rate (FDR) < 0. Read More

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http://dx.doi.org/10.1093/carcin/bgaa035DOI Listing

Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells.

Carcinogenesis 2020 Apr 7. Epub 2020 Apr 7.

Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, Medical Faculty, University of Cologne, Cologne, Germany.

Functioning mitochondria are crucial for cancer metabolism, but aerobic glycolysis is still considered to be an important pathway for energy production in many tumor cells. Here we show that two well established, classic Hodgkin lymphoma cell lines (cHL) harbor deleterious variants within mitochondrial DNA (mtDNA) and thus exhibit reduced steady state levels of respiratory chain complexes. However, instead of resulting in the expected bioenergetic defect, these mtDNA variants evoke a retrograde signaling response that induces mitochondrial biogenesis and ultimately results in increased mitochondrial mass as well as function and enhances proliferation in vitro as well as tumor growth in mice in vivo. Read More

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http://dx.doi.org/10.1093/carcin/bgaa032DOI Listing

BAI1 acts as a tumor suppressor in lung cancer A549 cells by inducing metabolic reprogramming via the SCD1/HMGCR module.

Carcinogenesis 2020 Apr 7. Epub 2020 Apr 7.

Lab of Pathology, Key Lab of Transplantation Engineering and Immunology, Ministry of Health, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Brain angiogenesis inhibitor 1 (BAI1) is an important tumor suppressor in multiple cancers. However, the mechanisms behind its anti-tumor activity, particularly the relationship between BAI1 and metabolic aberrant of a tumor, remained unveiled. This study aimed to investigate whether BAI1 could inhibit biological functions in lung cancer A549 cells and the critical regulating molecules that induce metabolic reprogramming. Read More

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http://dx.doi.org/10.1093/carcin/bgaa036DOI Listing
April 2020
5.334 Impact Factor

Prenatal stress enhances NNK-induced lung tumors in A/J mice.

Carcinogenesis 2020 Apr 6. Epub 2020 Apr 6.

Sidney Kimmel Cancer Center. Department of Oncology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Children born to women who experience stress during pregnancy have an increased risk of cancer in later life, but no previous animal studies have tested such a link. We questioned whether prenatal stress in A/J mice affected the development of lung tumors after postnatal response to tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Timed-bred A/J mice were randomly assigned on gestation day 12. Read More

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http://dx.doi.org/10.1093/carcin/bgaa033DOI Listing

Serine Threonine Kinase 11/Liver Kinase B1 Mutation in Sporadic Scirrhous-type Gastric Cancer Cells.

Carcinogenesis 2020 Mar 31. Epub 2020 Mar 31.

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Scirrhous-type gastric carcinoma (SGC), which is characterized by the rapid proliferation of cancer cells accompanied by extensive fibrosis, shows extremely poor survival. A reason for the poor prognosis of SGC is that the driver gene responsible for SGC has not been identified. To identify the characteristic driver gene of SGC, we examined the genomic landscape of six human SGC cell lines of OCUM-1, OCUM-2M, OCUM-8, OCUM-9, OCUM-12, and OCUM-14, using multiplex gene panel testing by next-generation sequencing. Read More

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http://dx.doi.org/10.1093/carcin/bgaa031DOI Listing

Cooperation of genes in HPV16 E6/E7-dependent cervico-vaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.

Carcinogenesis 2020 Mar 28. Epub 2020 Mar 28.

Department of Pathology, The University of Chicago, Chicago, IL, USA.

Human papillomavirus (HPV) infection is necessary but insufficient for progression of epithelial cells from dysplasia to carcinoma-in-situ to invasive cancer. The combination of mutant cellular and viral oncogenes that regulate progression of cervical cancer remains unclear. Using combinations of HPV16 E6/E7 (E+), mutant Kras (mKras) (K+) and/or loss of Pten (P-/-), we generated autochthonous models of cervical cancer without exogenous estrogen, carcinogen or promoters. Read More

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http://dx.doi.org/10.1093/carcin/bgaa027DOI Listing
March 2020
5.334 Impact Factor

Genetic Variants in Epithelial Mesenchymal Transition Genes as Predictors of Clinical Outcomes in Localized Prostate Cancer.

Carcinogenesis 2020 Mar 26. Epub 2020 Mar 26.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Epithelial mesenchymal transition (EMT) plays a pivotal role in the progression of prostate cancer (PCa). However, little is known about genetic variants in the EMT pathway as predictors of aggressiveness, biochemical recurrence (BCR), and disease reclassification in localized PCa.

Patients And Methods: In this multi-stage study, we evaluated 5,186 single nucleotide polymorphisms (SNPs) from 264 genes related to EMT pathway to identify SNPs associated with PCa aggressiveness and BCR in the MD Anderson PCa patient (MDA-PCa) cohort (N=1,762), followed by assessment of the identified SNPs with disease reclassification in the active surveillance (AS) cohort (N=392). Read More

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http://dx.doi.org/10.1093/carcin/bgaa026DOI Listing

Low carbohydrate diets containing soy protein and fish oil slow the growth of established NNK-induced lung tumors.

Carcinogenesis 2020 Mar 26. Epub 2020 Mar 26.

The Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada.

We recently found that a diet composed of 15% of total calories as carbohydrate (CHO), primarily as amylose, 35% soy protein and 50% fat, primarily as fish oil (FO), (15%Amylose/Soy/FO) was highly effective at preventing lung nodule formation in a nicotine-derived nitrosamine ketone (NNK)-induced lung cancer model. We asked herein whether adopting such a diet once cancers are established might also be beneficial. To test this, NNK-induced lung nodules were established in mice on a Western diet and the mice were then either kept on a Western diet or switched to various low CHO diets. Read More

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http://dx.doi.org/10.1093/carcin/bgaa028DOI Listing

Comparison of clinicopathological traits and prognostic factors of hepatocellular carcinoma with and without cirrhotic background.

Carcinogenesis 2020 Mar 19. Epub 2020 Mar 19.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The difference of the patients bearing hepatocellular carcinoma (HCC) with and without cirrhosis at clinical level has not been completely determined. This study compared their differences in clinicopathological traits and prognostic factors for recurrence-free survival (RFS) and overall survival (OS). Animal model was established to validate the result of clinical observation. Read More

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http://dx.doi.org/10.1093/carcin/bgaa024DOI Listing

Editorial.

Authors:
Curtis C Harris

Carcinogenesis 2020 Mar;41(1)

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http://dx.doi.org/10.1093/carcin/bgaa006DOI Listing

Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation.

Carcinogenesis 2020 Mar 11. Epub 2020 Mar 11.

Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.

Space radiation is characterized by high-linear energy transfer (LET) ionizing radiation. The relationships between the early biological effects of space radiation and the probability of cancer in humans are poorly understood. Bcl2 not only functions as a potent antiapoptotic molecule but also as an oncogenic protein that induces DNA replication stress. Read More

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http://dx.doi.org/10.1093/carcin/bgaa021DOI Listing

Read-through transcripts in lung: germline genetic regulation and correlation with the expression of other genes.

Carcinogenesis 2020 Mar 11. Epub 2020 Mar 11.

Genetic Epidemiology and Pharmacogenomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here we investigated whether the expression of read-through transcripts previously identified in the non-involved lung tissue of lung adenocarcinoma patients was genetically regulated. Data on genome-wide SNV genotypes and expression levels of 10 read-through transcripts in 201 samples of lung tissue were combined to identify expression quantitative trait loci (eQTLs). Read More

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http://dx.doi.org/10.1093/carcin/bgaa020DOI Listing

The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer.

Carcinogenesis 2020 Mar 11. Epub 2020 Mar 11.

Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.

Follow-up studies of Japanese patients who had undergone endoscopic resection (ER) for early esophageal squamous cell carcinoma (ESCC) have reported a high prevalence of metachronous SCC in the upper aerodigestive tract (UAT). This prospective multicenter cohort study followed up 330 Japanese patients after ER of ESCC for a median of 49.4 months. Read More

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http://dx.doi.org/10.1093/carcin/bgaa022DOI Listing