Search Our Scientific Publications & Authors

Taiwan J Obstet Gynecol 2018 Dec;57(6):825-829

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

Objective: Female pelvic floor disorders, including female stress urinary incontinence (SUI) or sexual dysfunction are notorious for affecting the quality of women's life. It is reported that laser therapy might result in collagen remodeling and improvement in tissue firmness. The study was conducted to evaluate the short-term outcome of female pelvic floor disorders treated by laser therapy. Read More

Menopause 2019 03;26(3):248-255

1st Department of Obstetrics and Gynecology, "Alexandra" Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Objective: The aim of this study is to assess the efficacy of microablative fractional CO2 laser therapy for genitourinary syndrome of menopause (GSM) management, when three, four, or five laser therapies were applied in a follow-up period of 12 months.

Methods: Retrospective study evaluating GSM symptoms at baseline, and 1, 3, 6, and 12 months after last laser therapy. Visual analog scale, International Consultation on Incontinence Questionnaires- Female Urinary Tract Symptoms, International Consultation on Incontinence Questionnaires-Urinary Incontinence Short Form, Urogenital Distress Inventory-6, and Female Sexual Function Index were used for assessment of GSM symptoms' intensity or bothering and parameters of sexual function. Read More

Curr Urol Rep 2018 Aug 17;19(10):83. Epub 2018 Aug 17.

Department of Urology, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA.

Purpose Of Review: The purpose of this article is to review the available data regarding the application and therapeutic outcomes of laser therapy for the treatment of genitourinary syndrome of menopause (GSM).

Recent Findings: There have been several studies regarding the use of laser therapy for the treatment of GSM. Most of these studies show a trend toward safe and effective treatment in the short term (less than or equal to 12 weeks). Read More

J Minim Invasive Gynecol 2019 Mar - Apr;26(3):404. Epub 2018 Jul 19.

Departments of Obstetrics and Gynecology (Drs. Seidler, Shabanov, Wenger, and Pluchino) and. Electronic address:

Study Objective: To demonstrate a safe laparoscopic procedure for diaphragmatic infiltrative endometriosis.

Design: Video case SETTING: Teaching hospital (Canadian Task Force classification III).

Patients: One patient presenting deep and severe diaphragmatic endometriosis. Read More

J Minim Invasive Gynecol 2019 Mar - Apr;26(3):450-455. Epub 2018 May 24.

Department of Gynecology, Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic of Barcelona, Faculty of Medicine, University of Barcelona, Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:

Study Objective: To evaluate serial generation of microparticles (MPs) after laparoscopic stripping or CO laser vaporization in the surgical treatment of patients with ovarian endometrioma (OE).

Design: A prospective, randomized, blinded, pilot study (Canadian Task Force classification I).

Setting: Tertiary care university hospital from December 2014 to July 2016. Read More

BMJ Open 2018 03 19;8(3):e020675. Epub 2018 Mar 19.

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.

Objectives: To evaluate cervical regeneration at 6 months following excisional treatment for high-grade cervical intraepithelial neoplasia (CIN), and to investigate the effect of cone dimensions, age of patients and technique of excision on the efficacy of the regeneration process.

Design: Prospective observational multicentric study.

Setting: Three tertiary care and research centres. Read More

Lasers Med Sci 2018 Jul 1;33(5):1047-1054. Epub 2018 Mar 1.

Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", via dell'Istria 65/1, 34100, Trieste, Italy.

The composition of vaginal microbiome in menopause and cancer survivor women changes dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of patients. Recent reports suggest that laser therapy may be valuable as a not hormonal therapeutic modality. The aim of the present study was to evaluate the effects of fractional CO laser treatment on the vaginal secretory pathway of a large panel of immune mediators, usually implicated in tissue remodeling and inflammation, and on microbiome composition in postmenopausal breast cancer survivors. Read More

Minerva Ginecol 2018 Feb 9;70(1):53-57. Epub 2017 Oct 9.

San Raffaele Scientific Institute for Research and Care, Milan, Italy.

Background: The advent of flexible CO2 laser fiber to gynecology arena might represent a turning point in the use of laser energy on a large-scale basis in gynecological surgery. However, there might be some concerns regarding the degree of surgical skills required to use the flexible system. The purpose of our study is to evaluate whether flexible CO2 laser fiber is technically accessible. Read More

J Low Genit Tract Dis 2017 10;21(4):e42-e44

1Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; and 2Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

J Low Genit Tract Dis 2017 Oct;21(4):279-283

1Woman's Health Sciences Department, Gynecologic Section, Università Politecnica delle Marche, Ancona, Italy; 2Gynecologic Oncology Unit, Department. of Obstetrics & Gynecology Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milano, Milan, Italy; 3Center for Gynecologic Oncology Prevention, AULSS 20, Verona, Italy; 4Local Health Authority of Reggio Emilia, Division of Obstetrics and Gynecology, Cesare Magati Hospital, Scandiano, Italy; and 5Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.

Objectives: The aim of the present study was to observe the trend of length of cone excisions in women treated with cervical excision procedure in five institutions of Central and Northern Italy.

Materials And Methods: A multicenter retrospective cohort study was conducted on women who underwent a cervical excision procedure between January 2006 and December 2014. The pertinent clinical, histopathological, and sociodemographic characteristics of each woman were collected. Read More

Maturitas 2017 Oct 21;104:24-28. Epub 2017 Jul 21.

Urogynaecology Unit, 1st Department of Obstetrics and Gynecology, "Alexandra" Hospital, National and Kapodistrian University of Athens, Greece.

Objectives: The aim of this prospective study was to assess the efficacy of 3, 4 or 5 CO-laser sessions for the management of the genitourinary syndrome of menopause (GSM).

Methods: Postmenopausal women with moderate to severe symptoms of dyspareunia, wanting to resume/retain sexual activity, were treated with 3-5 laser sessions depending on symptom severity/presence, sexual function, clinical findings and women's preference following the third laser application.

Main Outcomes: Severity of dyspareunia, dryness, sexual function, sexual satisfaction and frequency of sexual intercourse defined the primary outcomes. Read More

Arch Gynecol Obstet 2017 Nov 2;296(5):973-978. Epub 2017 Sep 2.

Section of Oncological Gynecology, Department of Woman and Child Health, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy.

Purpose: The aim of this study was to evaluate long-term effects of the fractional CO laser for the treatment of vulvovaginal atrophy (VVA) symptoms.

Methods: Women presenting with VVA symptoms and meeting inclusion criterion were enrolled to fractioned CO laser therapy. Patient's satisfaction was measured on five-point Likert scale at 4 weeks and 6, 12, 18, 24 months after treatment by interview and clinical examination for vaginal livability. Read More

Sex Med Rev 2017 10 23;5(4):486-494. Epub 2017 Aug 23.

Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy.

Introduction: Genitourinary syndrome of menopause (GSM) has a significant impact on the trophism of the genital and lower urinary tracts and can considerably impair sexual function. Fractional CO laser has a regenerative effect on vulvovaginal tissue trophism after menopause.

Aim: To review the available literature on the effect of fractional CO laser on the sexual function of postmenopausal women affected by GSM. Read More

Climacteric 2017 Aug 15;20(4):379-384. Epub 2017 May 15.

b Obstetrics and Gynaecology Unit, Umberto I Hospital, Department of Surgical Sciences, School of Medicine , University of Turin , Turin , Italy.

Objective: To evaluate the effects of CO laser in the treatment of vulvovaginal atrophy (VVA) in postmenopausal women.

Methods: VVA was assessed in 87 postmenopausal women (mean age 58.6 ± 6. Read More

Eur J Obstet Gynecol Reprod Biol 2017 Jun 2;213:39-44. Epub 2017 Apr 2.

San Raffaele University, San Raffaele Hospital, Italy.

Objectives: To evaluate the safety and long-term efficacy of fractional CO laser treatment in reducing the severity of symptoms of genitourinary syndrome of menopause (GSM) in menopausal women.

Study Design: 102 women presenting with symptomatic GSM were treated with the fractional CO laser (MonaLisa Touch, DEKA) system across a series of treatments delivered at intervals of six or more weeks. The Australian Pelvic Floor Questionnaire was used to gather data on sexual function and side-effects at three time-points across the study period (prospective panel design study). Read More

Maturitas 2017 May 4;99:10-15. Epub 2017 Feb 4.

Palacios Institute of Womeńs Health, Madrid, Spain.

Laser therapy has a therapeutic role in various medical conditions and most recently has gained interest as a non-hormonal treatment for genitourinary syndrome of menopause (GSM) and as a non-invasive option for stress urinary incontinence (SUI). Several therapies are available to alleviate GSM symptoms, including hormonal and non-hormonal products. Both microablative fractional CO laser and the non-ablative vaginal Er:YAG laser (VEL) induce morphological changes in the vaginal tissues, and data from non-randomized clinical trials suggest that laser therapy can alleviate vaginal dryness and dyspareunia. Read More

Photomed Laser Surg 2017 Mar 30;35(3):171-175. Epub 2016 Dec 30.

4 "Laser in Dermatology, " University of Rome Tor Vergata , Rome, Italy .

Background: The CO laser has become the gold standard treatment in dermatologic surgery for the treatment of a large number of skin and mucosal lesions. The introduction of the fractional micro-ablative technology represented an integration to the ablative resurfacing technique, reducing the healing time and the side effects.

Objective: Vaginal rejuvenation performed with this technique is a minimally invasive procedure that stimulates internal tissues of the female lower genital tract to regenerate the mucosa, improving tissue trophism and restoring the correct functionality. Read More

J Sex Med 2016 12 15;13(12):1915-1917. Epub 2016 Nov 15.

Lower Genital Tract Disease Unit, V. Buzzi Hospital, University of Milan, Milan, Italy.

Introduction: Chronic vulvar pain and burning remains one of the most perplexing problems faced by practicing gynecologists.

Aim: To evaluate the effectiveness and safety of the application of micro-ablative fractional CO laser to the vulvar vestibule in the management of patients with vulvar pain from vestibulodynia or genitourinary syndrome of menopause.

Methods: Patients (N = 70) underwent fractional micro-ablative CO laser treatment for vestibular pain plus vestibulodynia (n = 37) or genitourinary syndrome of menopause (n = 33). Read More

Maturitas 2016 Dec 16;94:131-136. Epub 2016 Sep 16.

Urogynecology Unit, 1st Department of Obstetrics and Gynecology, "Alexandra" Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Objectives: This study aimed to assess the effect of the Microablative Fractional CO Laser (CO-laser) therapy on vaginal pathophysiology and the symptoms of the Genitourinary Syndrome of Menopause (GSM).

Methods: Postmenopausal women with moderate to severe symptoms of GSM underwent three sessions of CO-laser therapy at monthly intervals. Participants were evaluated at baseline and 4 weeks after the last treatment. Read More

Climacteric 2016 Oct 24;19(5):512-8. Epub 2016 Aug 24.

a Urogynecology Unit, 1st Department of Obstetrics and Gynecology , "Alexandra" Hospital, Medical School, National and Kapodistrian University of Athens , Athens , Greece ;

Objectives: To assess the effect of microablative fractional CO2 laser (MFCO2-Laser) therapy on the vaginal microenvironment of postmenopausal women.

Methods: Three laser therapies at monthly intervals were applied in postmenopausal women with moderate to severe symptoms of genitourinary syndrome of menopause, pH of vaginal fluid >4.5 and superficial epithelial cells on vaginal smear <5%. Read More

Fertil Steril 2016 Nov 16;106(6):e14. Epub 2016 Aug 16.

Atlanta Center for Minimally Invasive Surgery and Reproductive Medicine, Atlanta, Georgia. Electronic address:

Objective: To report the medical and surgical management of a rare case of recurrent moss-like endometriosis and associated hemorrhagic ascites.

Design: Video description of the case, demonstration of the surgical technique, discussion of the histology, and review of endometriosis-associated ascites.

Setting: Tertiary referral center. Read More

Akush Ginekol (Sofiia) 2016 ;55(1):62-6

Aim: Short history of laser procedures in gynecology, benefits and new horizons. Read More

Curr Opin Obstet Gynecol 2015 12;27(6):504-8

aObstetrics and Gynecology Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, Milan, Italy bUrogynecology Unit, First Department of Obstetrics and Gynecology, National & Kapodistrian University of Athens, Athens, Greece.

Purpose Of Review: This article reviews the literature regarding the safety and efficacy of the use of a pulsed CO2 laser for the treatment of vulvovaginal atrophy (VVA).

Recent Findings: Prospective observational studies have demonstrated histological changes after the use of pulsed CO2 laser vaginally in atrophic conditions. Increased collagen and extracellular matrix production has been reported together with an increase in the thickness of the vaginal epithelium with the formation of new papilla. Read More

Maturitas 2015 Dec 12;82(4):342-5. Epub 2015 Aug 12.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Division of Urology, Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Genitourinary syndrome of menopause is a common condition that left untreated can progress and negatively affect quality of life and sexual function. Laser therapy has a therapeutic role for several gynecologic conditions and most recently has gained interest as a non-hormonal treatment for genitourinary syndrome of menopause (GSM). The laser is well tolerated and may increase thickness of the squamous epithelium and improve vascularity of the vagina. Read More

Arch Gynecol Obstet 2016 Mar 25;293(3):651-7. Epub 2015 Aug 25.

Department of Obstetrics and Gynecology, Sapporo Medical University, Minami 1 jo, Nishi 16 chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

Purpose: Uterine cervical conization is related to adverse pregnancy outcomes in subsequent pregnancies. To deal with this problem, we started conservative coin-shaped conization for reproductive-aged patients with cervical intraepithelial neoplasia (CIN). Here we report both the obstetrical and oncological impacts of this operation in comparison with the standard cone-shaped resection. Read More

Arch Gynecol Obstet 2016 Feb 2;293(2):415-9. Epub 2015 Aug 2.

Department of Gynaecology and Obstetrics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To characterize the clinical presentation and outcome of patients with vaginal intraepithelial neoplasia (VAIN).

Methods: Medical records of 65 women with VAIN treated between 2005 and 2012 at the colposcopy clinic of a German university hospital were retrospectively evaluated for VAIN grade, HPV status, VAIN localization, treatment method and relapse rate. Follow-up data were available for 53 patients (82 %). Read More

J Minim Invasive Gynecol 2015 Nov-Dec;22(7):1183-90. Epub 2015 Jun 16.

Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Study Objective: To compare the effectiveness and safety of a flexible carbon dioxide (CO2) laser fiber to the ultrasonic scalpel when employed through a robotic surgical system.

Design: Retrospective cohort study.

Design Classification: Level II-2 evidence. Read More

Maturitas 2015 May 14;81(1):100. Epub 2015 Mar 14.

Department of Urology, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.

Int Urogynecol J 2015 May;26(5):785

Academic Department of Obstetrics and Gynaecology, Imperial College Healthcare NHS Trust, South Wharf Road, London, W2 1NY, UK,

Int Urogynecol J 2015 May 27;26(5):783. Epub 2015 Mar 27.

Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Via Olgettina 58-60, 20132, Milan, Italy,

Menopause 2015 Aug;22(8):845-9

From the 1Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy; 2Urogynecology Unit, First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece; 3Department of Experimental Medicine, Histology, and Embryology, University of Pavia, Pavia, Italy; and 4Department of Dermatology, University of Insubria, Varese, Italy.

Objective: Microablative fractional CO2 laser has been proven to determine tissue remodeling with neoformation of collagen and elastic fibers on atrophic skin. The aim of our study is to evaluate the effects of microablative fractional CO2 laser on postmenopausal women with vulvovaginal atrophy using an ex vivo model.

Methods: This is a prospective ex vivo cohort trial. Read More

Maturitas 2015 Mar 25;80(3):296-301. Epub 2014 Dec 25.

Department of Obstetrics and Gynaecology, University Hospital "P. Giaccone", Palermo, Italy.

Objective: To evaluate the efficacy and feasibility of thermo-ablative fractional CO2 laser for the treatment of symptoms related to vulvo-vaginal atrophy (VVA) in post-menopausal women.

Methods: From April 2013 to December 2013, post-menopausal patients who complained of one or more VVA-related symptoms and who underwent vaginal treatment with fractional CO2 laser were enrolled in the study. At baseline (T0) and 30 days post-treatment (T1), vaginal status of the women was evaluated using the Vaginal Health Index (VHI), and subjective intensity of VVA symptoms was evaluated using a visual analog scale (VAS). Read More

Int Urogynecol J 2015 Feb 5;26(2):163-4. Epub 2014 Dec 5.

Department of Urogynaecology, Academic Department of Obstetrics and Gynaecology, S. Mary's Hospital, Mint Wing, South Wharf, W2 1NY, London, UK.

Climacteric 2015 Apr 16;18(2):219-25. Epub 2014 Dec 16.

Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital , Milan.

Objective: To investigate the effects of fractional microablative CO2 laser on sexual function and overall satisfaction with sexual life in postmenopausal women with vulvovaginal atrophy (VVA).

Method: This prospective study included 77 postmenopausal women (mean age 60.6 ± 6. Read More

Lasers Med Sci 2015 Jan 23;30(1):147-52. Epub 2014 Jul 23.

Departament of Gynecology and Obstetrics, Jagiellonian University Medical College, 23 Kopernika str, 31-501, Krakow, Poland.

Endometriosis is a chronic disease affecting mainly women of the reproductive age. Its most common manifestations include impaired fecundity, pelvic pain, and dyschezia. Laparoscopic removal of endometriotic foci remains to be the gold standard for the treatment of endometriosis. Read More

Acta Derm Venereol 2015 Feb;95(2):173-6

Department of Dermatovenereology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.

Risk of human papillomavirus (HPV) transmission during laser vaporisation of genital warts or loop electrode excision procedure is controversial. An oral rinse, a nasal swabs, history of HPV related diseases and data on HPV exposure were collected from 287 employees at departments of dermato-venerology and gynaecology in Denmark. A mucosal HPV type was found among 5. Read More

J Obstet Gynaecol Res 2014 Jun;40(6):1740-7

Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital of Capital Medical University, Beijing, China.

Aim: The aim of this study was to evaluate the therapeutic effect of laser vaporization for vaginal intraepithelial neoplasia (VAIN) after hysterectomy in Chinese women and to identify factors affecting persistence/recurrence.

Material And Methods: Twenty-eight VAIN patients after hysterectomy due to cervical intraepithelial neoplasia (group 1) and 11 VAIN patients due to cervical cancer (group 2) were reviewed retrospectively. All patients were treated with at least one episode of laser vaporization between 2010 and 2011, and then followed up every 3 months for at least 1 year. Read More

J Minim Invasive Gynecol 2014 Nov-Dec;21(6):1103-9. Epub 2014 May 22.

Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology, and Reproductive Biology, Boston, Massachusetts. Electronic address:

The objective of this experimental animal study was to compare the surgical precision of a flexible CO2 laser fiber with that of monopolar electrosurgery in porcine myometrium. The subjects were 6 live adult non-pregnant female pigs. Linear injury to the uterine horns was created using a flexible CO2 laser fiber at 5W, 10W, and 15W and with monopolar electrosurgery at 10W, 20W, 30W, and 40W in both cut and coagulation modes. Read More

Arch Gynecol Obstet 2014 Jul 24;290(1):115-9. Epub 2014 Jan 24.

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, 650-9, Yoksam-dong, Gangnam-gu, Seoul, 135-913, Korea.

Purpose: The aim of our study was to evaluate the risk factors for treatment failure of CO2 laser vaporization in patients with cervical intraepithelial neoplasia 2 (CIN2).

Methods: Medical records of patients who received either shallow or deep CO2 laser vaporization with biopsy-proven CIN2 during March 2007 to April 2011 were reviewed retrospectively. After laser vaporization, liquid-based cytology and human papilloma virus (HPV) DNA testing were checked in every follow-up visit. Read More

J Obstet Gynaecol 2013 Apr;33(3):225-31

Department of Obstetrics and Gynecology, Scripps Clinic Medical Group, San Diego, CA 92108, USA.

The term 'laser' is an acronym for Light Amplification by Stimulated Emission of Radiation. Lasers are commonly described by the emitted wavelength, which determines the colour of the light, as well as the active lasing medium. Currently, over 40 types of lasers have been developed with a wide range of both industrial and medical uses. Read More