125 results match your criteria Carbon Dioxide Laser Surgery for Cervical Dysplasia


Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study.

Int J Clin Oncol 2021 Apr 4;26(4):770-776. Epub 2021 Jan 4.

Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Cervical intraepithelial neoplasia (CIN) is a precancerous lesion that may progress to invasive cervical cancer without intervention. We aim to examine the prognostic outcomes and risk factors for recurrence after laser vaporization for CIN 3, CIN 2 with high-risk human papillomavirus (HPV) infection, and CIN 1 persisting for more than 2 years.

Methods: Between 2008 and 2016, a total of 1070 patients underwent cervical laser vaporization using a carbon dioxide laser. Read More

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[CO2 laser ablation of cervical endometrioid lesions - treatment efficacy evaluation].

Pol Merkur Lekarski 2019 Aug;47(278):60-64

Medicover Hospital, Department of Obstetric and Gynecology, Warsaw, Poland.

Endometriosis affects 10-15% of the female population of childbearing potential. Endometrioid lesions of the cervical surface are a rare manifestation of the disease. There are various complaints related to this particular form of endometriosis, making the diagnosis challenging. Read More

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Role of Close Endocervical Margin in Treatment Failure After Cervical Excision for Cervical Intraepithelial Neoplasia: A Retrospective Study.

Arch Pathol Lab Med 2019 08 19;143(8):1006-1011. Epub 2019 Feb 19.

From the Gynecological Oncology Unit (Drs Sopracordevole and del Fabro and Ms Buttignol) and the Pathology Unit (Drs Canzonieri and Alessandrini), Centro di Riferimento Oncologico-National Cancer Institute, Aviano, Italy; the Woman's Health Sciences Department, Gynecologic Section, Università Politecnica delle Marche, Ancona, Italy (Drs Carpini, Serri, and Ciavattini); and the Department of Obstetrics, Gynecology, and Pediatrics, Azienda Sanitaria Universitaria Integrata Udine, Udine, Italy (Dr Cagnacci). Dr Alessandrini is now with the General Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy.

Context.—: A significant negative trend in length of cone excision has been observed in recent years, leading to a higher percentage of positive endocervical excision margin and close (<1 mm) negative endocervical margin cases.

Objective. Read More

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Effect of age and cone dimensions on cervical regeneration: an Italian multicentric prospective observational study.

BMJ Open 2018 03 19;8(3):e020675. Epub 2018 Mar 19.

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Aviano, Italy.

Objectives: To evaluate cervical regeneration at 6 months following excisional treatment for high-grade cervical intraepithelial neoplasia (CIN), and to investigate the effect of cone dimensions, age of patients and technique of excision on the efficacy of the regeneration process.

Design: Prospective observational multicentric study.

Setting: Three tertiary care and research centres. Read More

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Therapeutic Assessment of Vulvar Squamous Intraepithelial Lesions with CO2 Laser Vaporization in Immunosuppressed Patients.

Rev Bras Ginecol Obstet 2018 Jan 16;40(1):26-31. Epub 2018 Jan 16.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.

Objective:  A vulvar squamous intraepithelial lesion is deemed to be a preceding lesion to vulvar cancer, especially in women aged under 40 years, holders of an acquired or idiopathic immunosuppression. Several treatments have been used to treat these lesions. One of the aesthetically acceptable therapeutic methods is the CO laser vaporization. Read More

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January 2018

Obstetrical prognosis of patients with cervical intraepithelial neoplasia (CIN) after "coin-shaped" conization.

Arch Gynecol Obstet 2016 Mar 25;293(3):651-7. Epub 2015 Aug 25.

Department of Obstetrics and Gynecology, Sapporo Medical University, Minami 1 jo, Nishi 16 chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

Purpose: Uterine cervical conization is related to adverse pregnancy outcomes in subsequent pregnancies. To deal with this problem, we started conservative coin-shaped conization for reproductive-aged patients with cervical intraepithelial neoplasia (CIN). Here we report both the obstetrical and oncological impacts of this operation in comparison with the standard cone-shaped resection. Read More

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Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia.

Arch Gynecol Obstet 2016 Feb 2;293(2):415-9. Epub 2015 Aug 2.

Department of Gynaecology and Obstetrics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To characterize the clinical presentation and outcome of patients with vaginal intraepithelial neoplasia (VAIN).

Methods: Medical records of 65 women with VAIN treated between 2005 and 2012 at the colposcopy clinic of a German university hospital were retrospectively evaluated for VAIN grade, HPV status, VAIN localization, treatment method and relapse rate. Follow-up data were available for 53 patients (82 %). Read More

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February 2016

Low prevalence of oral and nasal human papillomavirus in employees performing CO2-laser evaporation of genital warts or loop electrode excision procedure of cervical dysplasia.

Acta Derm Venereol 2015 Feb;95(2):173-6

Department of Dermatovenereology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.

Risk of human papillomavirus (HPV) transmission during laser vaporisation of genital warts or loop electrode excision procedure is controversial. An oral rinse, a nasal swabs, history of HPV related diseases and data on HPV exposure were collected from 287 employees at departments of dermato-venerology and gynaecology in Denmark. A mucosal HPV type was found among 5. Read More

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February 2015

Therapeutic effect of laser vaporization for vaginal intraepithelial neoplasia following hysterectomy due to premalignant and malignant lesions.

J Obstet Gynaecol Res 2014 Jun;40(6):1740-7

Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital of Capital Medical University, Beijing, China.

Aim: The aim of this study was to evaluate the therapeutic effect of laser vaporization for vaginal intraepithelial neoplasia (VAIN) after hysterectomy in Chinese women and to identify factors affecting persistence/recurrence.

Material And Methods: Twenty-eight VAIN patients after hysterectomy due to cervical intraepithelial neoplasia (group 1) and 11 VAIN patients due to cervical cancer (group 2) were reviewed retrospectively. All patients were treated with at least one episode of laser vaporization between 2010 and 2011, and then followed up every 3 months for at least 1 year. Read More

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Risk factors for treatment failure of CO2 laser vaporization in cervical intraepithelial neoplasia 2.

Arch Gynecol Obstet 2014 Jul 24;290(1):115-9. Epub 2014 Jan 24.

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, 650-9, Yoksam-dong, Gangnam-gu, Seoul, 135-913, Korea.

Purpose: The aim of our study was to evaluate the risk factors for treatment failure of CO2 laser vaporization in patients with cervical intraepithelial neoplasia 2 (CIN2).

Methods: Medical records of patients who received either shallow or deep CO2 laser vaporization with biopsy-proven CIN2 during March 2007 to April 2011 were reviewed retrospectively. After laser vaporization, liquid-based cytology and human papilloma virus (HPV) DNA testing were checked in every follow-up visit. Read More

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Antisepsis regimen in the surgical treatment of HPV generated cervical lesions: polyhexamethylene biguanide vs chlorhexidine. A randomized, double blind study.

Eur Rev Med Pharmacol Sci 2012 Dec;16(14):1994-8

Department of Obstetrics and Gynecology, University of Perugia, Perugia, Italy.

Introduction: To reduce the risk of local infections after surgical treatments for HPV infected cervical lesions, the post-operative regimen is generally based on the use of vaginal antimicrobial agents.

Aim: The efficacy and safety of polyhexamethylene biguanide-based vaginal suppositories was compared to a similar chlorhexidine-based treatment, in the post recovery regimen after surgical treatment of cervical lesions.

Materials And Methods: 50 women who underwent to CO2 laser therapy for cervical lesions were randomly assigned to receive 10 days of antiseptic treatment with chlorhexidine digluconate vaginal suppositories, or polyhexamethylene biguanide vaginal suppositories (Monogin®/Biguanelle® ovuli, Lo. Read More

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December 2012

[Item 149--Epithelial and melanotic skin tumors: human papillomavirus (HPV) tumors].

Authors:

Ann Dermatol Venereol 2012 Oct 31;139(11 Suppl):A144-9. Epub 2012 Jul 31.

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October 2012

Value-based medicine analysis on loop electrosurgical excision procedure and CO2 laser vaporization for the treatment of cervical intraepithelial neoplasia 2.

J Obstet Gynaecol Res 2012 Aug 8;38(8):1064-70. Epub 2012 May 8.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing, China.

Aim: The best treatment option for cervical intraepithelial neoplasia 2 (CIN2) is controversial and there is a lack of studies in value-based medicine. This multicenter comparative study was undertaken to evaluate the effectiveness, cost-effectives and quality of life (QOL) of loop electrosurgical excision procedure (LEEP) and CO(2) laser vaporization for the treatment of CIN2.

Material And Methods: A database of LEEP and laser vaporizations performed at three research centers was created. Read More

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Laser vaporization in the management of CIN.

Eur J Gynaecol Oncol 2010 ;31(1):83-6

Department of Gynaecology, Perinatology and Childhealth, University Sapienza, Rome, Italy.

Aims: To evaluate the effectiveness of laser CO2 vaporization in high-grade cervical intraepithelial neoplasias and to assess the diagnostic reliability of cytology, colposcopy, microbiology and HPV tests in predicting recurrence in a long-term outcome.

Methods: Forty-four patients affectd by high-grade cervical intraepithelial neoplasia (HG-CIN) were submitted to laser CO2 vaporization and followed-up a minimum of five years. Vaginal smears for microbiological examination were detected. Read More

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Management of relapsing cervical intraepithelial neoplasia.

J Reprod Med 2009 Aug;54(8):499-505

First Department of Obstetrics and Gynecology, University of Athens, Athens, Greece.

Objective: To evaluate relapsing cervical intraepithelial neoplasia (CIN) and establish the criteria of recurrence to assess management by laser CO2.

Study Design: Patients with histologically proved CIN after a primary conservative approach were the study population. Disease relapse was considered as residual or recurrent if diagnosed within or after the first year of follow-up. Read More

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Retrospective evaluation of CO(2) laser conization in pregnant women with carcinoma in situ or microinvasive carcinoma.

Gynecol Obstet Invest 2009 10;68(4):230-3. Epub 2009 Sep 10.

Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka, Japan.

Background: We evaluated the safety and efficacy of CO(2) laser conization in pregnant women with cervical intraepithelial neoplasia 3/carcinoma in situ (CIN3/CIS) or microinvasive carcinoma (MIC).

Objectives: A total of 49 pregnant women with biopsy-proven CIN3/CIS (30 patients) or MIC (19 patients) were studied.

Methods: Retrospective analysis based on clinical records. Read More

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February 2010

Conservative approach to preneoplastic cervical lesions in postmenopause.

Anticancer Res 2008 Nov-Dec;28(6B):3941-4

Department of Gynaecology, Perinatology and Child Health, University "Sapienza", 00161 Rome, Italy.

Aim: To evaluate the recurrence rate of high-grade squamous intraepithelial lesions in postmenopausal women previously submitted to laser CO2 conization and the role of persistent oncogenic HPV types.

Patients And Methods: Fifty-five patients with a cytological diagnosis of high-grade squamous intraepithelial lesions were triaged with a standard colposcopy. Hormonal replacement therapy was considered as significative in influencing cervical trophism. Read More

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February 2009

CO2 laser cylindrical excision or standard re-conization for persistent-recurrent high-grade cervical intraepithelial neoplasia (HG-CIN) in women of fertile age.

Anticancer Res 2008 Nov-Dec;28(6B):3871-5

Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Florence, Italy.

Aim: To investigate the therapeutic efficacy of cylindrical or cone-shaped excision performed by laser CO2 in the conservative management of persistent-recurrent high-grade cervical intraepithelial neoplasia (HG-CIN) in women of fertile age.

Patients And Methods: Ninety-four premenopausal patients with persistent-recurrent HG-CIN had undergone re-conization or cylindrical excision according to the time of reappearance of the disease. The length of the procedures, intra- and postoperative complications, height of the excised specimens, final histological findings and follow-up data were retrospectively evaluated. Read More

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February 2009

Oral contraceptives and clinical recurrence of human papillomavirus lesions and cervical intraepithelial neoplasia following treatment.

Int J Gynaecol Obstet 2008 Feb 19;100(2):175-8. Epub 2007 Nov 19.

Department of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy.

Objective: To evaluate the effect of oral contraceptive use on the recurrence rate of human papillomavirus (HPV) lesions and cervical intraepithelial neoplasia (CIN) following ablative or excisional procedures in a long-term follow-up.

Method: The study was conducted with 650 oral contraceptive users presenting with HPV lesions and/or CIN, and 670 women who had these lesions but did not use oral contraceptives acted as controls. The participants underwent cytologic evaluations, colposcopy, and direct biopsy, followed by either ablative treatment by laser carbon dioxide vaporization or excision by a loop electrosurgical excision procedure or cold knife conization. Read More

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February 2008

Feasibility and outcome of laser CO2 conization performed within the 18th week of gestation.

Int J Gynecol Cancer 2007 Jan-Feb;17(1):127-31

Department of Gynecology, Perinatology and Human Reproduction, School of Medicine, University of Florence, Via Morgagni 85, 50134 Florence, Italy.

The purpose of this study is to evaluate the feasibility, safety, and potential therapeutic benefit of laser CO(2) conization of the cervix for in situ and minimally invasive carcinoma diagnosed during pregnancy. Twenty-six pregnant patients with biopsy-proven carcinoma in situ/cervical intraepithelial neoplasia III but colposcopically suspicious for invasion underwent laser CO(2) conization during the 18th week of gestation in an outpatient setting under local anesthesia. No major intraoperative or postoperative complications occurred, and cervical cerclage was not required in any case. Read More

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Clinicopathologic outcomes of laser conization for high-grade cervical dysplasia.

Eur J Gynaecol Oncol 2004 ;25(3):305-7

Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

Purpose Of Investigation: To evaluate the incidence of thermal artifact and rates of persistent disease and recurrence in laser conization for cervical dysplasia.

Methods: A retrospective study examined the cases of 110 patients who underwent carbon dioxide laser conization for high-grade cervical dysplasia at our institution between January 1999 and March 2002. Rates of thermal artifact, persistent disease, recurrence, hemorrhage and cervical stenosis were investigated. Read More

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CO2 laser surgery for vulvar intraepithelial neoplasia. Excisional, destructive and combined techniques.

J Reprod Med 2002 Nov;47(11):913-8

Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Florence, Italy.

Objective: To evaluate CO2 laser excision, vaporization and combined techniques for treatment of vulvar intraepithelial neoplasia (VIN).

Study Design: Thirty-nine cases of VIN 3, 15 cases of VIN 2 and 9 of VIN 1, for a total of 63 patients with histologically proven VIN, underwent laser excision or vaporization under colposcopic guidance, using local anesthesia, in an outpatient setting or after day-surgery admission. Clinical aspects, cervical intraepithelial neoplasia (CIN) and vaginal intraepithelial neoplasia (VaIN) association, types of CO2 laser treatment, follow-up, recurrences and second treatments were evaluated. Read More

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November 2002

Vaginal intraepithelial neoplasia: treatment by carbon dioxide laser and risk factors for failure.

Eur J Obstet Gynecol Reprod Biol 2003 Jan;106(1):64-8

Department of Obstetrics and Gynecology, Yale University School of Medicine, Section of Gynecologic Oncology, New Haven, CT, USA.

Objective: To evaluate the effectiveness of CO(2) laser ablation of vaginal intraepithelial neoplasia (VAIN) and to define prognostic factors.

Study Design: Medical records of 24 patients with VAIN II or III, treated by CO(2) laser ablation from 1990 to 1998 were reviewed. The grade, location, and focality of the lesions, the age, follow-up period and menopausal status of the patients, the power and duration of laser ablation, the presence of concurrent cervical or vulvar neoplasia or previous hysterectomy were evaluated as possible prognostic factors. Read More

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January 2003

[Laser conization for cervical intraepithelial neoplasias, grade III. Personal experience of 77 cases].

Minerva Ginecol 2002 Dec;54(6):467-70

Divisione di Ginecologia Oncologica, IFO Polo Oncologico, Rome, Italy.

Background: Evalutation of the efficacy of laser conization for cervical high-grade squamous intraepithelial lesions (Hg-SIL).

Methods: A retrospective evaluation. Case collection: A total of 77 women, 47 outpatients and 30 inpatients with endocervical CIN3 or CIN2, were treated by carbon dioxide (CO2) laser between 1993 and 1995. Read More

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December 2002

Outcomes of carbon dioxide laser conization for the treatment of cervical intraepithelial neoplasia grade III.

Clin Exp Obstet Gynecol 2001 ;28(4):243-5

Department of Obstetrics and Gynecology, Aristoteleion University of Thessalonika, Greece.

Purpose: The aim of this study was to determine the rates of incomplete excision of cervical intraepithelial neoplasia (CIN) III after carbon dioxide laser conization, and the risk of reappearance of CIN depending on the excision margins.

Methods: A total of 153 women who underwent carbon dioxide laser conization for CIN III between 1988 and 1998 at our hospitals were eligible for inclusion in the study and their notes were retrospectively studied.

Results: Histological examination of the excision margins revealed complete excision in 134 (87. Read More

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Regular disappearance of the human papillomavirus genome after conization of cervical dysplasia by carbon dioxide laser.

Am J Obstet Gynecol 2000 Nov;183(5):1238-42

Department of Obstetrics and Gynecology, Umeâ University Hospital, Umeå, Sweden.

Objective: We wished to evaluate the effectiveness of treatment of cervical dysplasia by laser conization in relation to persistence of human papillomavirus after treatment.

Study Design: Of 203 women referred to colposcopy because of an abnormal Papanicolaou smear, 149 women could be followed up for 3 years. A total of 108 women were treated by carbon dioxide laser excision, 4 women were treated by carbon dioxide laser evaporation, and 37 women were merely followed up. Read More

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November 2000

[Utilization of CO2 lasers in continuous or pulsed mode for conizations: apropos of 230 cases].

Gynecol Obstet Fertil 2000 Jul-Aug;28(7-8):537-46

Centre de lutte contre le cancer de Midi-Pyrénées, Toulouse, France.

Objective: A retrospective study with the aim of analysing efficiency, anatomical and functional consequences of a conservative methodology for the treatment of cervical intra-epithelial neoplasias (CIN) using carbon dioxide laser.

Materials And Method: Two hundred and thirty patients were treated and studied with an average waiting period of 38 months. During the study new methodology allowed a cut in the pulse regimen with adjustments in high energy levels. Read More

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October 2000

Treatment of vaginal dysplasia: just a simple loop electrosurgical excision procedure?

Am J Obstet Gynecol 2000 Mar;182(3):731-2

Department of Obstetrics and Gynecology, Coastal Area Health Education Center, New Hanover Regional Medical Center, Wilmington, NC 28402-9025, USA.

We report a case of sigmoid perforation, peritonitis, and adult respiratory distress syndrome after a loop excision procedure for carcinoma in situ of the cervix and dysplasia of the vagina. Treatment of vaginal dysplasia with loop excision is potentially dangerous. Safer methods of management include carbon dioxide laser, topical 5-fluorouracil, and fulguration. Read More

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The use of carbon-dioxide laser surgery in the treatment of intraepithelial neoplasia of the uterine cervix.

Przegl Lek 1999 ;56(1):58-64

Department of Obstetrics and Gynecology, Spedali Civili University of Brescia, Italy.

From October 1989 to June 1997, 1841 patients (pts) suffering from different diseases of the lower genital tract have been treated with CO2 laser surgery in our Institution: among them, 782 were affected by cervical intraepithelial neoplasia (CIN). All pts underwent CO2 laser procedure for CIN after adequate colposcopic evaluation of the entire lower genital tract, colposcopic guided biopsy of the lesion, adequate pre-surgical work-up for possible infectious and coagulation associated disease. In 736 (94. Read More

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September 1999

Duration of pregnancy after carbon dioxide laser conization of the cervix: influence of cone height.

Obstet Gynecol 1997 Dec;90(6):978-82

Department of Obstetrics and Gynecology, Kantonsspital, Münsterlingen, Switzerland.

Objective: To determine if carbon dioxide laser conization of the cervix is a risk factor for preterm delivery in subsequent gestations and to evaluate whether there is any relationship between cone height and duration of pregnancy.

Methods: Patients of fertile age who had carbon dioxide laser conization were followed for reproductive events. Cases were matched one-to-one with controls for known risk factors for preterm delivery. Read More

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December 1997