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J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 1;1175:122751. Epub 2021 May 1.

Univ Franche - Comté, F-25000 Besançon, France; EA481 Neurosciences Intégratives et Cliniques/Pôle Chimie Analytique Bioanalytique et Physique (PCABP), F-25000 Besançon, France; CHRU Besançon, Pôle Pharmaceutique, F-25000 Besançon, France. Electronic address:

A simple and rapid Nano LC method has been developed for the screening of arginase inhibitors. The method is based on the immobilization of biotinylated arginase on a neutravidin functionalized nano HPLC capillary column. The arginase immobilization step performed by frontal analysis is very fast and only takes a few minutes. Read More

J Colloid Interface Sci 2021 Apr 28;599:837-848. Epub 2021 Apr 28.

Institute of Fluid Dynamics, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany; Institute of Process Engineering and Environmental Technology, Technische Universität Dresden, 01062 Dresden, Germany.

Hypothesis: The shear stress of the axisymmetric flow field triggers a nonuniform distribution of the surfactants at the surface of a rising bubble, known as stagnant cap. The formation of the stagnant cap gives rise to Marangoni stresses that reduce the mobility of the interface, which in return reduces the rising velocity. However, the conditions in technological processes usually deviate from the linear rise of a single bubble in a quiescent unbounded liquid. Read More

J Chromatogr A 2021 May 3;1648:462213. Epub 2021 May 3.

Institut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS-UM-ENSCM, Université de Montpellier, Montpellier, France. Electronic address:

Comprehensive characterization of physicochemical properties of monoclonal antibodies (mAbs) is a critical process to ensure their quality, efficacy, and safety. For this purpose, mAb analysis at different levels (bottom-up, middle-up) is a common approach that includes rather complex multistep sample preparation (reduction, digestion). To ensure high analysis performance, the development of fully integrated methodologies is highly valuable. Read More

J Complement Integr Med 2021 May 14. Epub 2021 May 14.

Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Current modalities for treating polycystic ovary syndrome (PCOS) are not curative and using them for a long period is associated with adverse effects. According to Persian Medicine recommendations, wet cupping on calf muscles can induce menstrual bleeding. In the present study, the effect of wet-cupping (traditional bleeding from capillary vessels) was assessed on menstrual cycles (as primary outcome), hirsutism, and laboratory manifestation of PCOS. Read More

Physiol Rep 2021 May;9(9):e14863

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Intermittent hypoxia (IH) is a feature of obstructive sleep apnea (OSA), a condition highly associated with hypertension-related cardiovascular diseases. Repeated episodes of IH contribute to imbalance of angiogenic growth factors in the hypertrophic heart, which is key in the progression of cardiovascular complications. In particular, the interaction between vascular endothelial growth factor (VEGF) and the kallikrein-kinin system (KKS) is essential for promoting angiogenesis. Read More

Acta Anaesthesiol Scand 2021 May 15. Epub 2021 May 15.

Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Section of Cardiothoracic Anaesthesia and Intensive Care, Gothenburg, Sweden.

Background: The atrial natriuretic peptide released from the heart regulates intravascular volume and is suspected to increase capillary permeability. Contradictory results regarding ANP and glycocalyx degradation have been reported. The aim of this study was to investigate if an infusion of ANP causes degradation of the endothelial glycocalyx. Read More

J Eur Acad Dermatol Venereol 2021 May 15. Epub 2021 May 15.

Dermatology -IRCCS Policlinico di Sant'Orsola - Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Alma Mater, Studiorum University of Bologna, Italy.

Background: Scalp psoriasis is often undiagnosed or inadequately treated. The patient himself underestimates the seriousness of this hair disease and consults too late to a dermatologist.

Objectives: The aim of our study was to create a correlation between the clinical patterns and trichoscopy of scalp psoriasis such in a way to help the clinician to make the diagnosis and select the appropriate therapy. Read More

Chemistry 2021 May 14. Epub 2021 May 14.

Saitama University, Graduate School of Science and Engineering, 255 Shimo-Okubo, Sakura-ku, 3388570, Saitama, JAPAN.

In DNA aptamer selection, existing methods do not discriminate aptamer sequences based on their binding affinity and function and the reproducibility of the selection is often poor, even for the selection of well-known aptamers like those that bind the commonly used model protein thrombin. In the present study, a novel single-round selection method (SR-CE selection) was developed by combining capillary electrophoresis (CE) with next generation sequencing. Using SR-CE selection, a successful semi-quantitative and semi-comprehensive aptamer selection for thrombin was demonstrated with high reproducibility for the first time. Read More

Electrophoresis 2021 May 14. Epub 2021 May 14.

Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

Human c-KIT oncogene is known to regulate cell growth and proliferation, and thus, acts as a probable target in the treatment of gastrointestinal tumors (GIST). To identify small molecule ligands which can specifically bind with the G-quadruplex (G4) in the c-KIT promoter region as potential antitumor agents, we propose the combination of electrospray ionization mass spectrometry (ESI-MS), capillary electrophoresis frontal analysis (CE-FA), and Taylor dispersion analysis (TDA) to accurately investigate the G4/ligands binding properties. First, ESI-MS was used for initial screening of natural products (NPs). Read More

Sci Rep 2021 May 14;11(1):10348. Epub 2021 May 14.

School of Mechanical Engineering, Tongji University, Caoan Highway 4800, Shanghai, 201804, China.

A mathematical model based on heat and mass transfer processes in the porous wick of electronic cigarettes was established to describe the atomization of e-liquids according to max liquid temperature, vaporization rate and thermal efficiency in a single puff. Dominant capillary-evaporation effects were defined in the model to account for the effects of electrical power, e-liquid composition and porosity of the wick material on atomization and energy transmission processes. Liquid temperature, vaporization rate, and thermal efficiency were predicted using the mathematical model in 64 groups, varying with electrical power, e-liquid composition and wick porosity. Read More

Nat Commun 2021 May 14;12(1):2836. Epub 2021 May 14.

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Bioinspired vascular networks transport heat and mass in hydrogels, microfluidic devices, self-healing and self-cooling structures, filters, and flow batteries. Lengthy, multistep fabrication processes involving solvents, external heat, and vacuum hinder large-scale application of vascular networks in structural materials. Here, we report the rapid (seconds to minutes), scalable, and synchronized fabrication of vascular thermosets and fiber-reinforced composites under ambient conditions. Read More

Retina 2021 May 3. Epub 2021 May 3.

Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany Department of Ophthalmology, Fulda Medical Center, Fulda, Germany.

Aim: To analyze the influence of a cilioretinal artery on macular and peripapillary vessel density in healthy eyes as measured using optical coherence tomography angiography (OCTA).

Methods: 83 eyes of 83 patients were included in this study. Optical coherence tomography angiography was performed using the RTVue XR Avanti with AngioVue (Optovue Inc). Read More

J Exp Med 2021 Jul 14;218(7). Epub 2021 May 14.

Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.

Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is believed to begin with DCs approaching and entering into afferent lymphatic capillaries. From capillaries, DCs slowly crawl into lymphatic collectors, where lymph flow induced by collector contraction supports DC detachment and thereafter rapid, passive transport to dLNs. Performing a transcriptomics analysis of dermal endothelial cells, we found that inflammation induces the degradation of the basement membrane (BM) surrounding lymphatic collectors and preferential up-regulation of the DC trafficking molecule VCAM-1 in collectors. Read More

Blood Adv 2021 May;5(10):2447-2455

University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA.

Inadequate diagnostics compromise cancer care across lower- and middle-income countries (LMICs). We hypothesized that an inexpensive gene expression assay using paraffin-embedded biopsy specimens from LMICs could distinguish lymphoma subtypes without pathologist input. We reviewed all biopsy specimens obtained at the Instituto de Cancerología y Hospital Dr. Read More

Phys Rev Lett 2021 Apr;126(17):174503

Université de Bordeaux & CNRS, LOMA (UMR 5798), 33405 Talence, France.

We report measurements of resonant thermal capillary oscillations of a hemispherical liquid gas interface obtained using a half bubble deposited on a solid substrate. The thermal motion of the hemispherical interface is investigated using an atomic force microscope cantilever that probes the amplitude of vibrations of this interface versus frequency. The spectrum of such nanoscale thermal oscillations of the bubble surface presents several resonance peaks and reveals that the contact line of the hemispherical bubble is pinned on the substrate. Read More

J Am Heart Assoc 2021 May 14:e019755. Epub 2021 May 14.

Center for Translational Medicine Lewis Katz School of Medicine Temple University Philadelphia PA.

Background Impaired angiogenic abilities of the microvascular endothelial cell (MVEC) play a crucial role in diabetes mellitus-impaired ischemic tissue repair. However, the underlying mechanisms of diabetes mellitus-impaired MVEC function remain unclear. We studied the role of serum-derived small extracellular vesicles (ssEVs) in diabetes mellitus-impaired MVEC function. Read More

Adv Biol (Weinh) 2021 May 13:e2000427. Epub 2021 May 13.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.

Alveolar-capillary basement membrane (BM) is ultra-thin (<2 µm) extracellular matrix that maintains integral epithelial-endothelial cell layers. In vitro reconstructions of alveolar-capillary barrier supported on synthetic scaffolds closely resembling the fibrous and ultra-thin natural BM are essential in mimicking the lung pathophysiology. Although BM topology and dimensions are well known to significantly influence cellular behavior, conventionally used BM mimics fail to recreate this natural niche. Read More

Ir J Med Sci 2021 May 13. Epub 2021 May 13.

Department of Diabetes and Endocrinology Beaumont Hospital and RCSI Medical School, Dublin, Ireland.

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition characterised by autoimmune destruction of the pancreatic beta cell. It is associated with macrovascular and microvascular complications. Tight glycaemic control has been shown to ameliorate the long-term complications of T1DM, but this benefit has to be balanced with the risk and fear of hypoglycaemia. Read More

Ann Transl Med 2021 Apr;9(8):719

Burn Institute, The Fourth Medical Center of the PLA General Hospital, Beijing, China.

Objective: We aimed to review and discuss some of the latest research results related to post-burn pathophysiological changes and provide some clues for future study.

Background: Burns are one of the most common and serious traumas and consist of a series of pathophysiological changes of thermal injury. Accompanied by thermal damage to skin and soft tissues, inflammatory mediators are released in large quantities. Read More

Eur J Case Rep Intern Med 2021 28;8(4):002554. Epub 2021 Apr 28.

Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal.

Proteus syndrome is an extremely rare disorder that manifests as an asymmetric, disproportionate overgrowth of any connective tissue, such as bone, fat or epidermal nevi, in a mosaic or patchy pattern. It has an estimated prevalence of less than 1/1,000,000 live births. The diagnosis can be difficult because the phenotypes of the patients are variable. Read More

Wei Sheng Yan Jiu 2021 Mar;50(2):310-314

Occupational Hygiene Technology Services Co. , Ltd. , Nanhai West Oil Corporation, Zhanjiang 524057, China.

Objective: To establish solvent desorption gas chromatograph method for o-toluidine determination in workplace air.

Methods: The o-toluidine vapour in workplace air was collected with silicone tube, and desorbed with absolute ethanol. Then the desorption solution was separated with polyethylene glycol HP-INNOWax capillary column(30 m×0. Read More

Opt Express 2021 Apr;29(8):11854-11868

This study experimentally demonstrates a high-sensitivity fiber-optic relative humidity (RH) sensor based on sensitivity amplification and a reduction mechanism, employing an internal-external Fabry-Perot cavity (IEFPC) Vernier effect and a chitosan film as a Fabry-Perot (FP)-sensing cavity. The proposed sensor is constructed using cascaded FP interferometers comprised of an air cavity formed by a hollow-core fiber (HCF), a chitosan cavity, and an air-chitosan hybrid cavity. The chitosan cavity is fabricated by dipping the HCF into a chitosan solution to form a thin chitosan film. Read More

Int Immunopharmacol 2021 May 10;96:107739. Epub 2021 May 10.

Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Toll-like receptor 7 (TLR7) is a sensor of microbial ssRNA that participates in the immune response process in many diseases. We herein sought to establish the role of TLR7 in Pseudomonas aeruginosa pneumonia. Pneumonia model was created by intratracheally injecting Pseudomonas aeruginosa and the effects of TLR7 on survival, bacterial burden, lung pathology, cytokine and chemokine production, and pulmonary leukocyte recruitment were measured after Pseudomonas aeruginosa challenge. Read More

Microvasc Res 2021 May 10:104177. Epub 2021 May 10.

Samsun Education and Research Hospital, Department of Dermatology, TR-55000 İlkadim, Samsun (Turkey).

Background: Obstructive Sleep Apnea Syndrome (OSAS) have frequent association with comorbidities and this makes it an independent risk factor for cardiovascular disease. Not only endothelial dysfunction, but also arterial stiffening, increased inflammatory mediators, oxidative stress after hypoxemia that develops due to OSAS, cause vascular pathologies in all diameters of vessels. Nail bed capillaroscopy is a simple, noninvasive, useful method to examine microcirculation and evaluate nail bed capillary abnormalities in diseases that cause vascular damage. Read More

Adv Mater 2021 May 13:e2003559. Epub 2021 May 13.

CAS Key Laboratory of Bio-Inspired Materials and Interface Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Unwanted protein adsorption deteriorates fouling processes and reduces analytical device performance. Wettability plays an important role in protein adsorption by affecting interactions between proteins and surfaces. However, the principles of protein adsorption are not completely understood, and surface coatings that exhibit resistance to protein adsorption and long-term stability still need to be developed. Read More

PLoS One 2021 13;16(5):e0251385. Epub 2021 May 13.

Department of Anatomic Pathology and Forensic Medicine, College of Health Sciences, Nile University of Nigeria, Abuja, Nigeria.

The diagnosis of thoracic endometriosis (TE) is challenging, hence resulting in under-diagnosis as well as long delays before arriving at a correct definitive diagnosis. Our aim is to review the histopathological findings in TE, summarise the diagnostic features, identify any major histo-morphological indicator(s) hitherto unrecognised as such, suggest diagnostic criteria; all with the aim of improving the diagnostic capacity and reducing observer error even where the clinical suspicion is low. A case-control study in which a search in the pathology archives of a referral hospital over a 10-year period was conducted. Read More

Nano Lett 2021 May 13. Epub 2021 May 13.

Instituto de Ciencia de Materiales de Madrid, CSIC, c/Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain.

Capillary condensation of water from vapor is an everyday phenomenon which has a wide range of scientific and technological implications. Many aspects of capillary condensation are not well understood such as the structure of interfacial water, the existence of distinct properties of confined water, or the validity of the Kelvin equation at nanoscale. We note the absence of high-spatial resolution images inside a meniscus. Read More

Transpl Int 2021 May 13. Epub 2021 May 13.

Department of Pathology, Medical University Vienna, Vienna, Austria.

Background: Gene expression profiling of renal allograft biopsies revealed the Duffy antigen receptor for chemokines (DARC) as being strikingly upregulated in antibody-mediated rejection (ABMR). DARC has previously been shown to be associated with endothelial injury. This study aimed at assessing the value of DARC immunohistochemistry as diagnostic marker in ABMR. Read More

Langmuir 2021 May 13. Epub 2021 May 13.

Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy 502 285, Telangana India.

We investigate the evaporation dynamics of a sessile droplet of ethanol-water binary mixtures of different compositions laden with alumina nanoparticles and compare with the no-loading condition at different substrate temperatures. Shadowgraphy and infrared imaging methods are used, and the experimental images are postprocessed using a machine learning technique. We found that the loading and no-loading cases display distinct wetting and contact angle dynamics. Read More

Adv Clin Exp Med 2021 May 12. Epub 2021 May 12.

Laboratory of Immunopathology, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.

Background: NF-κB is an essential player in cancer biology, especially in tumor development, due to its constitutive activation, and because a four-base deletion (ATTG) in the NF-κB1 promoter region at site -94, alters mRNA stability and regulates translation efficiency. This polymorphism is a good candidate risk marker and modulator of clinical course in chronic lymphocytic leukemia (CLL). As the effect of this NF-κB1 gene polymorphism has not been studied in patients with CLL so far, the present study was undertaken to find out whether the NF-κB1 promoter -94 ins/del ATTG polymorphism might be an essential genetic risk factor and/or modulatory disease player associated with CLL. Read More