130 results match your criteria Cannabis and cannabinoid research[Journal]


Cannabinoid Inheritance Relies on Complex Genetic Architecture.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):105-116. Epub 2020 Feb 27.

Department of Chemistry and Biology, Ryerson University, Toronto, Canada.

Understanding the inheritance of cannabinoid compounds in will facilitate effective crop breeding and careful regulation of controlled substances. The production of two key cannabinoids, Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), is partially controlled by two additive loci. Here, we present the first study to search for evidence of alternate genetic models describing the inheritance and expression of cannabinoids. Read More

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http://dx.doi.org/10.1089/can.2018.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173683PMC

Evaluation of Breath and Plasma Tetrahydrocannabinol Concentration Trends Postcannabis Exposure in Medical Cannabis Patients.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):99-104. Epub 2020 Feb 27.

School of Medicine, Wayne State University, Detroit, Michigan.

The legalization of cannabis in Canada brings novel challenges across various fronts, such as policy development, law enforcement, and public health and safety. It is imperative to improve our understanding of the mechanisms and trends surrounding cannabis use to develop efficacious methods of tackling these challenges. Patients' breath collection was achieved using the ExaBreath device from SensAbues. Read More

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http://dx.doi.org/10.1089/can.2018.0070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173673PMC

Oral Cannabidiol Does Not Convert to Δ-THC or Δ-THC in Humans: A Pharmacokinetic Study in Healthy Subjects.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):89-98. Epub 2020 Feb 27.

Prati Donaduzzi & Cia Ltda, Toledo, Brazil.

Recent studies have suggested that cannabidiol (CBD) could interconvert into Delta-8- and Delta-9- tetrahydrocannabinol. Thus, we tested the plasma samples of 120 healthy human subjects (60 male and 60 female), 60 in fasting and the other 60 under normal feeding conditions after acute administration of an oral solution containing CBD 300 mg. To do this, we developed a bioanalytical method to determine CBD and the presence of THC in plasma samples by Ultra-High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Read More

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http://dx.doi.org/10.1089/can.2019.0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173681PMC

Bidirectional Longitudinal Associations Between Cannabis Use and Body Mass Index Among Adolescents.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):81-88. Epub 2020 Feb 27.

Center for Children and Families, Department of Psychology, Florida International University, Miami, Florida.

Literature on the association between cannabis use and body mass index (BMI) among adults suggests that greater cannabis use is associated with a lower BMI. However, results are mixed among adolescents, with both cross-sectional and longitudinal studies finding positive, negative, and nonsignificant associations between cannabis use and BMI. This longitudinal study aims to shed light on these associations by prospectively examining the associations between cannabis use and BMI across a 2-year window in a large sample of adolescent cannabis users. Read More

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http://dx.doi.org/10.1089/can.2019.0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173669PMC

A Comprehensive Patient and Public Involvement Program Evaluating Perception of Cannabis-Derived Medicinal Products in the Treatment of Acute Postoperative Pain, Nausea, and Vomiting Using a Qualitative Thematic Framework.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):73-80. Epub 2020 Feb 27.

Division of Surgery, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Cannabis-derived medicinal products (CDMPs) have antiemetic properties and in combination with opioids have synergistic analgesic effects in part signaling through the delta and kappa opioid receptors. The objective of this patient and public involvement program was to determine perception of perioperative CDMPs in our local population to inform design of a clinical trial. A qualitative evaluation was conducted utilizing a focus group, semistructured interviews and a community event. Read More

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http://dx.doi.org/10.1089/can.2019.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173671PMC

Binge and Cannabis Co-Use Episodes in Relation to White Matter Integrity in Emerging Adults.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):62-72. Epub 2020 Feb 27.

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.

Growing evidence suggests that cannabis and alcohol (and especially binge alcohol drinking) use independently alters neural structure and functioning, particularly during sensitive developmental time periods (e.g., emerging adulthood). Read More

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http://dx.doi.org/10.1089/can.2018.0062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173670PMC

Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J Mice.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):51-61. Epub 2020 Feb 27.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany.

Chronic stress causes a variety of physiological and behavioral alterations, including social impairments, altered endocrine function, and an increased risk for psychiatric disorders. Thereby, social stress is one of the most effective stressful stimuli among mammals and considered to be one of the major risk factors for the onset and progression of neuropsychiatric diseases. For analyzing the effects of social stress in mice, the resident/intruder paradigm of social defeat is a widely used model. Read More

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http://dx.doi.org/10.1089/can.2019.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173677PMC

Effects of Oleamide on the Vasomotor Responses in the Rat.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):42-50. Epub 2020 Feb 27.

Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de Mexico, Distrito Federal, Mexico.

Cardiovascular effects of endocannabinoids (eCBs) have generated considerable interest since it has been suggested that the eCB system could become the new pharmacological target, either by blocking its activity or by promoting its effects on several cardiovascular diseases such as hypovolemic and septic shock or hypertension. The purpose of this study was to examine the effects of oleamide on several vasomotor responses in adult rats. Blood pressure (BP) was measured both directly and indirectly. Read More

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http://dx.doi.org/10.1089/can.2019.0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173668PMC

Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ-Tetrahydrocannabinol.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):32-41. Epub 2020 Feb 27.

School of Osteopathic Medicine, Campbell University, Buies Creek, North Carolina.

Synthetic cannabinoids (SCs) are commonly found in preparations used as recreational drugs. Although severe adverse health effects are not generally associated with cannabis use, a rising number of studies document seizures and even death after SC use. In this study, a mouse model is used to investigate the hypothesis that SCs are more toxic than Δ-tetrahydrocannabinol (THC), the principal psychoactive constituent of cannabis. Read More

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http://dx.doi.org/10.1089/can.2019.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173680PMC

Immune Responses Regulated by Cannabidiol.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):12-31. Epub 2020 Feb 27.

Department of Basic Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.

Cannabidiol (CBD) as Epidiolex (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Read More

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http://dx.doi.org/10.1089/can.2018.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173676PMC

Endocannabinoids and Stroke Prevention: Review of Clinical Studies.

Cannabis Cannabinoid Res 2020 Mar 27;5(1):6-11. Epub 2020 Feb 27.

Community Internal Medicine, Mayo Clinic, Rochester, Minnesota.

The societal burden of ischemic stroke suggests a need for additional therapeutic categories in stroke prevention. Modulation of the endocannabinoid system (ECS) is a rational target for stroke prevention because of its effects on inflammation, vascular tone, and metabolic balance, all well-described stroke risk factors. In this article, we summarize the existing ECS clinical studies in human subjects' research as they relate to conventional vascular risk factors associated with ischemic stroke. Read More

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http://dx.doi.org/10.1089/can.2018.0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173678PMC

Racism and Its Effect on Cannabis Research.

Authors:
Robert Solomon

Cannabis Cannabinoid Res 2020 Mar 27;5(1):2-5. Epub 2020 Feb 27.

Center for the Study of Cannabis and Community & Economic Development Clinic, The University of California, Irvine School of Law, Irvine, California.

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http://dx.doi.org/10.1089/can.2019.0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173675PMC

Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.

Cannabis Cannabinoid Res 2019 6;4(4):240-254. Epub 2019 Dec 6.

Department of Pharmaceutics, University of Florida, Gainesville, Florida.

Cannabis is the most widely used illicit drug in the US, and cannabis use among young adults continues to rise. Previous studies have shown that chronic administration of delta 9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, induces dependence in animal models. Because smoking is the most frequent route of THC self-administration, it is critical to investigate the effects of cannabis smoke inhalation. Read More

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http://dx.doi.org/10.1089/can.2019.0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933521PMC
December 2019

Anandamide Is Related to Clinical and Cardiorespiratory Benefits of Aerobic Exercise Training in Migraine Patients: A Randomized Controlled Clinical Trial.

Cannabis Cannabinoid Res 2019 9;4(4):275-284. Epub 2019 Dec 9.

Hospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo, Brazil.

Since endocannabinoids have been implicated in migraine pathophysiology, we conducted a randomized, controlled clinical trial to test the effects of a 12-week aerobic exercise intervention on plasma anandamide (AEA) and its relation with clinical, psychological, and cardiorespiratory outcomes. Episodic migraine patients taking no preventive drugs and nonheadache individuals were recruited from Hospital São Paulo and a tertiary headache clinic between March 2012 and March 2015. Participants were randomly assigned to receive aerobic exercise or enter the waitlist. Read More

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http://dx.doi.org/10.1089/can.2018.0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922061PMC
December 2019

Treatment of Gilles de la Tourette Syndrome with Cannabis-Based Medicine: Results from a Retrospective Analysis and Online Survey.

Cannabis Cannabinoid Res 2019 9;4(4):265-274. Epub 2019 Dec 9.

Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.

Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder that is characterized by motor and vocal tics and psychiatric comorbidities, including attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive behavior/disorder (OCB/OCD). From anecdotal reports and preliminary controlled studies, it is suggested that cannabis-based medicine (CBM) may improve tics and comorbidities in adults with GTS. This study was designed to further investigate efficacy and safety of CBM in GTS and specifically compare effects of different CBM. Read More

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http://dx.doi.org/10.1089/can.2018.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922065PMC
December 2019

Human Pharmacokinetic Parameters of Orally Administered Δ-Tetrahydrocannabinol Capsules Are Altered by Fed Versus Fasted Conditions and Sex Differences.

Cannabis Cannabinoid Res 2019 6;4(4):255-264. Epub 2019 Dec 6.

Aurora Cannabis, Inc., Leduc, Canada.

There is variability in the reported Δ-tetrahydrocannabinol (THC) and 11-hydroxy-tetrahydrocannabinol (11-OH-THC) pharmacokinetic (PK) and pharmacodynamic (PD) parameters between studies and there is limited investigation into how the presence of food or sex affect these parameters. In this study, we examined the PK and PD parameters of an encapsulated THC extract and its major active metabolite, 11-OH-THC, under different fed states. The study was a single-dose, randomized, double-blinded, four-way crossover investigation. Read More

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http://dx.doi.org/10.1089/can.2019.0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922062PMC
December 2019

2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity.

Cannabis Cannabinoid Res 2019 9;4(4):231-239. Epub 2019 Dec 9.

Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

The cannabinoid type 1 (CB1) receptor and cannabinoid type 2 (CB2) receptor are widely expressed in the body and anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are their best characterized endogenous ligands. The diacylglycerol lipases (diacylglycerol lipase alpha and diacylglycerol lipase beta) not only synthesize essentially all the 2-AG in the body but also generate other monoacylglycerols, including 2-linoleoylglycerol (2-LG). This lipid has been proposed to modulate endocannabinoid (eCB) signaling by protecting 2-AG from hydrolysis. Read More

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http://dx.doi.org/10.1089/can.2019.0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922063PMC
December 2019

The Impact of Perioperative Cannabis Use: A Narrative Scoping Review.

Cannabis Cannabinoid Res 2019 6;4(4):219-230. Epub 2019 Dec 6.

Department of Anesthesiology and Pain Medicine, Toronto General Hospital, University of Toronto, Toronto, Canada.

As countries progressively embrace the legalization of both medicinal and recreational cannabis, there remains a significant knowledge gap when it comes to the perioperative uses of cannabis, as well as the management of cannabis users. This review summarizes the information available on the subject based on existing published studies. Articles outlining the physiological changes occurring in the human body during acute and chronic use of cannabis (outside the context of anesthesia) are also taken into consideration as understanding these changes allows a more calculated approach to better anticipate patients' needs in the perioperative setting. Read More

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http://dx.doi.org/10.1089/can.2019.0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922064PMC
December 2019

Correction to: by Gamage TF, Anderson JC, and Abood ME. Cannabis Cannabinoid Res. 2016;1(1):272-280. DOI: 10.1089/can.2016.0028.

Authors:

Cannabis Cannabinoid Res 2019;4(4):285-286. Epub 2019 Dec 9.

[This corrects the article DOI: 10.1089/can.2016. Read More

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http://dx.doi.org/10.1089/can.2016.0028.correxDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923809PMC
December 2019

Cannabis Consumption in People Living with HIV: Reasons for Use, Secondary Effects, and Opportunities for Health Education.

Cannabis Cannabinoid Res 2019 23;4(3):204-213. Epub 2019 Sep 23.

Department of Biological Sciences, University of Quebec at Montreal (UQAM), Montreal, Canada.

Rates of cannabis consumption range from 40% to 74% among people living with HIV (PLWH). Little is known about the reasons for cannabis use, related modes of administration, effectiveness for symptom relief, or undesirable effects in the modern antiretroviral therapy (ART) era. Our aim was to conduct an exploratory study to identify potential areas for further evaluation and intervention. Read More

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http://dx.doi.org/10.1089/can.2018.0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757238PMC
September 2019
1 Read

Role of Cannabinoids and Terpenes in Cannabis-Mediated Analgesia in Rats.

Cannabis Cannabinoid Res 2019 23;4(3):177-182. Epub 2019 Sep 23.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi.

has been used for centuries in treating pain. However, the analgesic role of many of its constituents including terpenes is unknown. This research examined the contributions of terpenes (volatile oil) and cannabinoids in cannabis-mediated analgesia in rats. Read More

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http://dx.doi.org/10.1089/can.2018.0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757239PMC
September 2019

Cannabinoids, Pain, and Opioid Use Reduction: The Importance of Distilling and Disseminating Existing Data.

Cannabis Cannabinoid Res 2019 23;4(3):158-164. Epub 2019 Sep 23.

Institute of Cognitive Science, University of Colorado Boulder, Boulder, Colorado.

The high prevalence of chronic pain conditions combined with an over-reliance on opioid prescriptions has resulted in an opioid epidemic and a desperate need for solutions. There is some debate about whether cannabis might play a role in addressing chronic pain conditions as well as the opioid epidemic. Recent surveys suggest that a large number of people are using cannabis as a treatment for pain and to reduce use of opioids, and cannabis-derived products demonstrate at least modest efficacy in the treatment of pain in randomized controlled trials. Read More

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http://dx.doi.org/10.1089/can.2018.0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757236PMC
September 2019

Waiting for the Entourage.

Authors:
Daniele Piomelli

Cannabis Cannabinoid Res 2019 23;4(3):137-138. Epub 2019 Sep 23.

Departments of Anatomy and Neurobiology, Biological Chemistry and Pharmacology, University of California, Irvine, Irvine, California.

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http://dx.doi.org/10.1089/can.2019.29014.dpiDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760171PMC
September 2019

Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis.

Cannabis Cannabinoid Res 2019 23;4(3):214-218. Epub 2019 Sep 23.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Canada.

Benzodiazepines are a class of medication with sedative properties, commonly used for anxiety and other neurological conditions. These medications are associated with several well-known adverse effects. This observational study aims to investigate the reduction of benzodiazepine use in patients using prescribed medical cannabis. Read More

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http://dx.doi.org/10.1089/can.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757237PMC
September 2019

Potency Analysis of Medical Marijuana Products from New York State.

Cannabis Cannabinoid Res 2019 23;4(3):195-203. Epub 2019 Sep 23.

New York State Department of Health, Wadsworth Center, Albany, New York.

In the United States, medical marijuana programs have been established in 29 states and the District of Columbia. In 2014, New York State (NYS) approved medical marijuana legislation, and its program became fully operational in January of 2016. Products manufactured under the auspices of the program may be used by certified patients in NYS for the treatment of 1 of 12 qualifying medical conditions. Read More

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http://dx.doi.org/10.1089/can.2018.0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757241PMC
September 2019

Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses.

Cannabis Cannabinoid Res 2019 23;4(3):183-194. Epub 2019 Sep 23.

Centre for Molecular Design and Preformulations, and Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Canada.

Phytocannabinoids, characteristic compounds produced by medical cannabis, interact with cannabinoid (CB) receptors (CB1 and CB2) as well as other receptor systems to exhibit their corresponding pharmacological effects. In their natural form, CBs such as Δ-tetrahydrocannabinolic acid and cannabidiolic acid are inactive at these receptors, while their decarboxylated forms (Δ-tetrahydrocannabinol and cannabidiol, respectively) are potent ligands at CB receptors. Thus, extraction and processing of medical cannabis for active constituents are important. Read More

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http://dx.doi.org/10.1089/can.2018.0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757234PMC
September 2019

Absence of Entourage: Terpenoids Commonly Found in Do Not Modulate the Functional Activity of Δ-THC at Human CB and CB Receptors.

Cannabis Cannabinoid Res 2019 23;4(3):165-176. Epub 2019 Sep 23.

Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia.

Compounds present in such as phytocannabinoids and terpenoids may act in concert to elicit therapeutic effects. Cannabinoids such as Δ-tetrahydrocannabinol (Δ-THC) directly activate cannabinoid receptor 1 (CB) and cannabinoid receptor 2 (CB); however, it is not known if terpenoids present in also affect cannabinoid receptor signaling. Therefore, we examined six common terpenoids alone, and in combination with cannabinoid receptor agonists, on CB and CB signaling . Read More

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http://dx.doi.org/10.1089/can.2019.0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757242PMC
September 2019

Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders.

Cannabis Cannabinoid Res 2019 13;4(1):51-61. Epub 2019 Mar 13.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.

Synthetic cannabinoid mixtures have been easily accessible for years, leading to the belief that these products were natural and harmless, which contributed to their popularity. Nevertheless, there are many reports of users ending up in hospital due to severe side effects such as tachycardia, aggression, and psychosis. Controlled studies on the effects of synthetic cannabinoids on human performance are lacking. Read More

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http://dx.doi.org/10.1089/can.2018.0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661919PMC
March 2019
1 Read

Endocannabinoid System and the Kidneys: From Renal Physiology to Injury and Disease.

Cannabis Cannabinoid Res 2019 13;4(1):10-20. Epub 2019 Mar 13.

University of California-Irvine, School of Medicine, Orange, California.

As the prevalence of kidney disease continues to rise worldwide, there is accumulating evidence that kidney injury and dysfunction, whether acute or chronic, is associated with major adverse outcomes, including mortality. Meanwhile, effective therapeutic options in the treatment of acute kidney injury (AKI) and chronic kidney disease (CKD) have been sparse. Many of the effective treatments that are routinely utilized for different pathologies in patients without kidney disease have failed to demonstrate efficacy in those with renal dysfunction. Read More

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http://dx.doi.org/10.1089/can.2018.0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653784PMC
March 2019
6 Reads

Fast and Sensitive Quantification of Δ-Tetrahydrocannabinol and Its Main Oxidative Metabolites by Liquid Chromatography/Tandem Mass Spectrometry.

Cannabis Cannabinoid Res 2019 14;4(2):110-123. Epub 2019 Jun 14.

Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California.

Few animal studies have evaluated the pharmacological effects of Δ-tetrahydrocannabinol (THC) in relation to its pharmacokinetic properties. Understanding this relationship is essential, however, if comparisons are to be drawn across conditions-such as sex, age, and route of administration-which are associated with variations in the absorption, metabolism, and distribution of THC. As a first step toward addressing this gap, in this report, we describe a rapid, sensitive, and accurate method for the quantification of THC and its main oxidative metabolites, and apply it to representative rodent tissues. Read More

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http://dx.doi.org/10.1089/can.2018.0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590723PMC
June 2019
1 Read

Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.

Cannabis Cannabinoid Res 2019 14;4(2):88-101. Epub 2019 Jun 14.

Department of Anatomy and Neurobiology, Medical Sciences Campus, University of Puerto Rico (MSC-UPR), San Juan, Puerto Rico.

The cannabinoid receptor 2 (CB2) was previously implicated in brain functions, including complex behaviors. Here, we assessed the role of CB2 in selected swimming behaviors in zebrafish larvae and developed an upscalable whole-organism approach for CB2 ligand screening. Using CRISPR-Cas9 technology, we generated a novel null allele ( ) and a stable homozygote-viable loss-of-function (CB2-KO) line. Read More

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http://dx.doi.org/10.1089/can.2018.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590727PMC
June 2019
8 Reads

Systemic Blockade of the CB Receptor Augments Hippocampal Gene Expression Involved in Synaptic Plasticity but Perturbs Hippocampus-Dependent Learning Task.

Cannabis Cannabinoid Res 2019 13;4(1):33-41. Epub 2019 Mar 13.

Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina.

Chronic and acute agonism as well as acute antagonism of CB receptors reveal modulation of learning and memory during stable performance of a delayed-nonmatch-to-sample (DNMS) memory task. However, it remains unclear how chronic blockade of the CB receptor alters acquisition of the behavioral task. We examined the effects of chronic rimonabant exposure during DNMS task acquisition to determine if blockade of the CB receptor with the antagonist rimonabant enhanced acquisition of operant task. Read More

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http://dx.doi.org/10.1089/can.2018.0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484354PMC
March 2019
1 Read

A Cost-Effectiveness Model for Adjunctive Smoked Cannabis in the Treatment of Chronic Neuropathic Pain.

Cannabis Cannabinoid Res 2019 13;4(1):62-72. Epub 2019 Mar 13.

Department of Psychiatry, University of California San Diego, La Jolla, California.

A recent meta-analysis affirmed the benefit of medicinal cannabis for chronic neuropathic pain, a disabling and difficult-to-treat condition. As medicinal cannabis use is becoming increasingly prevalent among Americans, an exploration of its economic feasibility is warranted. We present this cost-effectiveness analysis of adjunctive cannabis pharmacotherapy for chronic peripheral neuropathy. Read More

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http://dx.doi.org/10.1089/can.2018.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446169PMC
March 2019
11 Reads

Role of Steroids on the Membrane Binding Ability of Fatty Acid Amide Hydrolase.

Cannabis Cannabinoid Res 2019 13;4(1):42-50. Epub 2019 Mar 13.

European Center for Brain Research (CERC)/Santa Lucia Foundation, Rome, Italy.

Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that gets in contact with a lipophilic substrate in the lipid bilayer, and then cleaves it into water soluble products. FAAH plays a critical role in modulating content and biological activity of endocannabinoids (eCBs), and its function is affected by membrane lipids. Increasing evidence suggests that also steroids can modulate endocannabinoid signaling, both in the central nervous system and at the periphery. Read More

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http://dx.doi.org/10.1089/can.2018.0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446164PMC
March 2019
2 Reads

Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature.

Cannabis Cannabinoid Res 2019 13;4(1):3-9. Epub 2019 Mar 13.

Department of Pediatrics, MIND Institute, University of California Davis Medical Center, Sacramento, California.

Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and cognitive deficits, as well as populations with endocannabinoid deficiencies, such as those who suffer from FXS. The objective of this study was to provide a brief narrative review of recent literature on endocannabinoids and FXS and to present a case series describing three patients with FXS who were treated with oral CBD-enriched (CBD+) solutions. Read More

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http://dx.doi.org/10.1089/can.2018.0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446166PMC
March 2019
24 Reads

Synthetic Cannabinoid Activity Against Colorectal Cancer Cells.

Cannabis Cannabinoid Res 2018 21;3(1):272-281. Epub 2018 Dec 21.

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, and new therapeutic strategies are still required. Here we screened a synthetic cannabinoid library to identify compounds that uniformly reduce the viability of seven CRC cell lines. Seven distinct CRC cell lines were treated with 10 μM cannabinoid compounds (from a library of 370 molecules) for 48 h, and cell viability was subsequently measured with MTS assay. Read More

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http://dx.doi.org/10.1089/can.2018.0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340378PMC
December 2018
2 Reads

Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Users.

Cannabis Cannabinoid Res 2018 21;3(1):259-271. Epub 2018 Dec 21.

Department of Biological Sciences, Indiana University South Bend, South Bend, Indiana.

Obesity is treatment-resistant, and is linked with a number of serious, chronic diseases. Adult obesity rates in the United States have tripled since the early 1960s. Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CBR and leading to increased caloric intake, reduced metabolic rates, and weight gain. Read More

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http://dx.doi.org/10.1089/can.2018.0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340377PMC
December 2018
1 Read

The Anti-Inflammatory Properties of Terpenoids from .

Cannabis Cannabinoid Res 2018 26;3(1):282-290. Epub 2018 Dec 26.

Department of Medicinal and Natural Products, Institute for Drug Research, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.

Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized. The aim of this study was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD). Essential oils prepared from three monoecious nonpsychoactive chemotypes of Cannabis were analyzed for their terpenoid content and subsequently studied pharmacologically for their anti-inflammatory properties and . Read More

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http://dx.doi.org/10.1089/can.2018.0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308289PMC
December 2018
4 Reads

Exploring 6-Azaindole and 7-Azaindole Rings for Developing Cannabinoid Receptor 1 Allosteric Modulators.

Cannabis Cannabinoid Res 2018 10;3(1):252-258. Epub 2018 Dec 10.

Department of Pharmaceutical Sciences, Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, Texas.

Org27569 is a prototypical allosteric modulator of the cannabinoid receptor 1 (CB). It belongs to the indole-2-carboxamide scaffold and has been intensively investigated in pharmacology and in structure-activity relationship (SAR) studies. Although azaindoles are rare in natural products and differ only by the presence of an extra ring nitrogen, they were demonstrated as valuable bioisosteres in many pharmacologically important molecules. Read More

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https://www.liebertpub.com/doi/10.1089/can.2018.0046
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http://dx.doi.org/10.1089/can.2018.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290480PMC
December 2018
11 Reads

Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use.

Cannabis Cannabinoid Res 2018 10;3(1):242-251. Epub 2018 Dec 10.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California.

Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful to the developing adolescent brain compared with adult-onset usage. However, the long-term effects of heavy, adolescent CB use on brain structure and cognitive performance in late-life remain unknown. Read More

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https://www.liebertpub.com/doi/10.1089/can.2018.0035
Publisher Site
http://dx.doi.org/10.1089/can.2018.0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290479PMC
December 2018
42 Reads

Cannabidiol's Upregulation of -acyl Ethanolamines in the Central Nervous System Requires -acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Cannabis Cannabinoid Res 2018 30;3(1):228-241. Epub 2018 Nov 30.

Program in Neuroscience, Indiana University Bloomington, Bloomington, Indiana.

Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are bioactive cannabinoids. We recently showed that acute THC administration drives region-dependent changes in the mouse brain lipidome. This study tested the hypothesis that cell lines representing cell types present in the central nervous system (CNS), neurons (N18 cells), astrocytes (C6 glioma cells), and microglia (BV2 cells) would respond differently to THC, CBD, or their combination. Read More

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http://dx.doi.org/10.1089/can.2018.0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277981PMC
November 2018
2 Reads

Oral Ingestion of : Risks, Benefits, and Effects on Malaria-Infected Hosts.

Cannabis Cannabinoid Res 2018 26;3(1):219-227. Epub 2018 Nov 26.

Malaria Research Laboratories, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.

The emergence of a multidrug-resistant strain of () raises concern about malaria control strategies. Unfortunately, the role(s) of natural plants/remedies in curtailing malaria catastrophe remains uncertain. The claims of potential antimalarial activity of have not been well established nor the consequences defined. Read More

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http://dx.doi.org/10.1089/can.2018.0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260522PMC
November 2018
41 Reads

Systematics at the Levels of Family, Genus, and Species.

Cannabis Cannabinoid Res 2018 1;3(1):203-212. Epub 2018 Oct 1.

Department of Molecular Biology, GW Pharmaceuticals, Cambridge, United Kingdom.

New concepts are reviewed in systematics, including phylogenetics and nomenclature. The family now includes , , and eight genera formerly in the . Grouping , , and actually goes back 250 years. Read More

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https://www.liebertpub.com/doi/10.1089/can.2018.0039
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http://dx.doi.org/10.1089/can.2018.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225593PMC
October 2018
31 Reads

Oncology Clinicians and the Minnesota Medical Cannabis Program: A Survey on Medical Cannabis Practice Patterns, Barriers to Enrollment, and Educational Needs.

Cannabis Cannabinoid Res 2018 1;3(1):195-202. Epub 2018 Oct 1.

Minnesota Department of Health, St. Paul, Minnesota.

Medical cannabis has been available in the State of Minnesota since July 2015 through the Minnesota Medical Cannabis Program (MMCP). Our study aimed to delineate oncology providers' views on medical cannabis, identify barriers to patient enrollment, and assess clinicians' interest in a clinical trial of medical cannabis in patients with stage IV cancer. From June to August 2017, we distributed a 14-question survey to Minnesota oncology physicians, advanced practice nurses, and physician assistants who care for adults and children with cancer. Read More

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https://www.liebertpub.com/doi/10.1089/can.2018.0029
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http://dx.doi.org/10.1089/can.2018.0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225592PMC
October 2018
20 Reads

Multiple Sclerosis, Cannabis Use, and Clinical Disability: A Preliminary [F]-Fluorodeoxyglucose Positron Emission Tomography Study.

Cannabis Cannabinoid Res 2018 13;3(1):213-218. Epub 2018 Oct 13.

Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado.

Long-term consequences of medicinal cannabis use in people with multiple sclerosis (PwMS) are unknown. This study investigated whether PwMS using cannabis had lower resting brain glucose uptake (GU) and worse clinical test results compared with nonusers. Sixteen PwMS, eight users, underwent clinical testing followed by [F]-Fluorodeoxyglucose positron emission tomography/computed tomography imaging. Read More

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https://www.liebertpub.com/doi/10.1089/can.2018.0019
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http://dx.doi.org/10.1089/can.2018.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186162PMC
October 2018
17 Reads

Regulatory Status of Cannabidiol in the United States: A Perspective.

Cannabis Cannabinoid Res 2018 27;3(1):190-194. Epub 2018 Sep 27.

Kight Law Office LLC dba Kight On Cannabis, Asheville, North Carolina.

Cannabidiol (CBD) is 1 of > 100 cannabinoids found in L. ( or ). Despite its complex and rapidly evolving regulatory status in the United States, projected retail sales of CBD products-hemp, Cannabis and pharmaceutical-are as high as $1. Read More

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http://dx.doi.org/10.1089/can.2018.0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154432PMC
September 2018

Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia.

Cannabis Cannabinoid Res 2018 19;3(1):171-178. Epub 2018 Sep 19.

Neurophysiology and Molecular Neurology Lab, Department of Medical Physiology and Biophysics, Faculty of Medicine, Universidad de Sevilla, Seville, Spain.

Perinatal hypoxic-ischemic (HI) encephalopathy is defined as a neurological syndrome where the newborn suffers from acute ischemia and hypoxia during the perinatal period. New therapies are needed. The acylethanolamides, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), possess neuroprotective properties, and they could be effective against perinatal HI. Read More

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https://www.liebertpub.com/doi/10.1089/can.2018.0013
Publisher Site
http://dx.doi.org/10.1089/can.2018.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148719PMC
September 2018
3 Reads

Emerging Evidence for Cannabis' Role in Opioid Use Disorder.

Cannabis Cannabinoid Res 2018 1;3(1):179-189. Epub 2018 Sep 1.

Department of Anesthesiology, Pain Center, Washington University School of Medicine, St. Louis, Missouri.

The opioid epidemic has become an immense problem in North America, and despite decades of research on the most effective means to treat opioid use disorder (OUD), overdose deaths are at an all-time high, and relapse remains pervasive. Although there are a number of FDA-approved opioid replacement therapies and maintenance medications to help ease the severity of opioid withdrawal symptoms and aid in relapse prevention, these medications are not risk free nor are they successful for all patients. Furthermore, there are legal and logistical bottlenecks to obtaining traditional opioid replacement therapies such as methadone or buprenorphine, and the demand for these services far outweighs the supply and access. Read More

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http://dx.doi.org/10.1089/can.2018.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135562PMC
September 2018
29 Reads

Endocannabinoid-Enhanced "Liking" in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals.

Cannabis Cannabinoid Res 2018 1;3(1):166-170. Epub 2018 Jul 1.

Department of Neurobiology and Behavior, The University of California, Irvine, Irvine, California.

Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial "hedonic hotspot" in nucleus accumbens (NAc) shell enhances hedonic impact, or "liking" reactions to sweet tastes. In this study, we probed within this hotspot the relationship between endocannabinoid and opioid signals in hedonic enhancement. Specifically, we asked whether enhancement of sucrose "liking" by intra-NAc microinjections of the endocannabinoid anandamide requires concurrent endogenous opioid signaling. Read More

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http://dx.doi.org/10.1089/can.2018.0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069591PMC
July 2018
35 Reads