18,983 results match your criteria Cannabis Compound Abuse


Tobacco and cannabis co-use and interrelatedness among adults.

Addict Behav 2018 Nov 27;90:354-361. Epub 2018 Nov 27.

Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC, USA.

Cannabis and tobacco co-use is prevalent, but consensus regarding the reasons for co-use among adults and the degree of interrelatedness between these substances is lacking. Reasons for co-use have been explored with younger users, but little data exists for more experienced users with entrenched patterns of co-use. The goal of this study was to examine characteristics and patterns of cannabis-tobacco co-use among adults in the Southeastern United States (US), where there is a legal landscape of generally restrictive cannabis legislation coupled with more permissive tobacco control compared to other US regions. Read More

View Article
November 2018
1 Read

Enhancing effects of acute exposure to cannabis smoke on working memory performance.

Neurobiol Learn Mem 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address:

Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how acute exposure to cannabis smoke affects working memory performance in a rat model. Read More

View Article
December 2018
4 Reads

Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users.

Pharmacol Biochem Behav 2018 Dec 3. Epub 2018 Dec 3.

New York State Psychiatric Institute, New York, NY, United States of America; Columbia University Medical Center, New York, NY, United States of America.

Cannabis is the most widely used illicit drugs and the changing legal, political and cultural climate will likely increase cannabis use further. One factor that may underlie the transition from recreational use to problematic use is stress. The hormone oxytocin (OXT) modulates stress and may have therapeutic efficacy for substance use disorders, but few studies have examined OXT in cannabis users. Read More

View Article
December 2018
2 Reads

Cannabinoid exposure and altered DNA methylation in rat and human sperm.

Epigenetics 2018 Dec 6. Epub 2018 Dec 6.

b Department of Psychiatry and Behavioral Sciences , Duke University Medical Center , Durham . NC 27705 , USA.

Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Read More

View Article
December 2018
5 Reads

Simultaneous quantification of thirteen cannabinoids and metabolites in human plasma by liquid chromatography tandem mass spectrometry in adult epilepsy patients.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Department of Experimental and Clinical Pharmacology and.

Background: A sensitive, robust method was developed and validated to quantitate thirteen major natural cannabinoid parent and metabolite compounds in human plasma at or below 0.5 ng/mL.

Methods: A liquid chromatography-tandem mass spectrometry method was developed and validated to measure thirteen cannabinoid compounds: cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabinol (CBN), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabichromene (CBC), Δ-tetrahydocannabinol (THC), Δ-tetrahydrocannabinolic acid A (THCA), Δ-tetrahydrocannabivarin (THCV), 11-hydroxy-Δ-tetrahydrocannbinol (11-OH-THC), 11-nor-9-carboxy-Δ-tetrahydrocannbinol (THC-COOH), and 11-nor-9-carboxy-Δ-tetrahydrocannabinol-glucuronide (THC-COOH-glu). Read More

View Article
December 2018
1 Read

Risky sexual behavior among adolescents: The role of decision-making, problems from cannabis use and externalizing disorder symptoms.

J Clin Exp Neuropsychol 2018 Dec 6:1-12. Epub 2018 Dec 6.

b Center for Children and Families , Florida International University , Miami , FL, USA.

Introduction: Previous research has demonstrated that externalizing symptoms, cannabis use problems, and poor decision-making abilities are each independently related to risky sexual behavior (RSB). However, few studies have examined the joint effect of these factors on RSB among a sample of adolescents.

Methods: The current study addresses this gap in the literature by examining how externalizing disorder symptoms, cannabis use, and decision-making abilities interact to predict RSB among a sample of adolescents (n = 204; M = 15. Read More

View Article
December 2018
1 Read

Cannabinoid drugs: will they relieve or exacerbate tinnitus?

Curr Opin Neurol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago Medical School, and the Brain Health Research Centre, Dunedin.

Purpose Of Review: Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Read More

View Article
November 2018
1 Read

Marijuana Use in Transplantation: A Call for Clarity.

Clin Transplant 2018 Dec 2:e13456. Epub 2018 Dec 2.

Transplant and Immunocompromised Host Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Transplant centers have varying policies for marijuana (MJ) use in donors, transplant candidates and recipients. Rationales for these differences range from concerns for fungal complications, impaired adherence and drug interactions. This paper reviews the current status of MJ policies and practices in transplant centers and results of a survey sent to the American Society of Transplantation (AST) membership by the Executive Committee of the AST Infectious Diseases Community of Practice. Read More

View Article
December 2018

When Neuroscience Meets Pharmacology: A Neuropharmacology Literature Analysis.

Front Neurosci 2018 16;12:852. Epub 2018 Nov 16.

The Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Magdalenka, Poland.

Considering the enormous progress in the field of neuropharmacology and its global importance, as well as the lack of bibliometric studies examining this field as a whole, it is a high time to assess the prevailing topics and citation performances of its research works. : Web of Science (WoS) was searched to identify relevant neuropharmacology articles, which were analyzed with reference to (1) publication year, (2) journal title, (3) total citation count, (4) authorship, (5) WoS category, and (6) manuscript type. The identified manuscripts were analyzed with VOSviewer for further bibliometric parameters, such as citation analysis of institutions, countries/regions, and journals, and to visualize the citation patterns of the terms appearing in the titles and abstracts. Read More

View Article
November 2018

Methylphenidate's effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls.

Neuropsychopharmacology 2018 Dec 1. Epub 2018 Dec 1.

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

Methylphenidate (MPH) is a first line treatment for ADHD and is also misused as a purported cognitive enhancer, yet its effects on brain function are still poorly understood. Recent functional magnetic resonance imaging (fMRI) studies showed that MPH altered cortico-striatal resting functional connectivity (RFC). Here we investigated the effects of MPH in thalamic connectivity since the thalamus modulates striato-cortical signaling. Read More

View Article
December 2018

Synthetic cannabinoids and endometrial stromal cell fate: dissimilar effects of JWH-122, UR-144 and WIN55,212-2.

Toxicology 2018 Nov 28. Epub 2018 Nov 28.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n.º 228, Porto, Portugal. Electronic address:

The emergence of synthetic cannabinoids (SCBs) as drugs of abuse in readily available "Spice" smoking blends has exposed users to much more potent cannabinoids than the phytocannabinoids present in Cannabis sativa L.. Increasing reports of adverse reactions are emerging in the clinical literature. Read More

View Article
November 2018

The Effects of Substance Abuse on Blood Glucose Parameters in Patients with Diabetes: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2018 Nov 29;15(12). Epub 2018 Nov 29.

Department of Family Care & Mental Health, University of Greenwich, London SE9 2UG, UK.

: People who abuse substances are at increased risk of metabolic syndrome and diabetes resulting partly from increased cell damage and due to the effects of opioids on glucose homeostasis. Therefore, people with diabetes who abuse substances may carry greater health risks than the general population resulting from their effect on glucose metabolism. These substances may be in the form of cannabis, hallucinogens, opioids, and stimulants. Read More

View Article
November 2018
1 Read

The Therapeutic Potential of Cannabinoids in Dermatology

Skin Therapy Lett 2018 11;23(6):1-5

Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC, USA

Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic conditions. This review thus assesses the therapeutic potential of phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids in the management of cutaneous disease. Read More

View Article
November 2018
2 Reads

Improving police conceptual knowledge of Mexico's law on cannabis possession: Findings from an assessment of a police education program.

Am J Addict 2018 Dec;27(8):608-611

Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla.

Background And Objectives: Policing practices do not reflect recent decriminalization of drug possession in Mexico. We assessed knowledge of cannabis law as part of a police education program (PEP) post-drug law reform in Tijuana.

Methods: Officers took pre-/post-PEP surveys; random subsample (n = 759) received follow-up assessments. Read More

View Article
December 2018

Cannabis-based products for pediatric epilepsy: A systematic review.

Epilepsia 2018 Dec 4. Epub 2018 Dec 4.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Objective: To assess the benefits and harms of cannabis-based products for pediatric epilepsy.

Methods: We identified in this living systematic review randomized controlled trials (RCTs) and nonrandomized studies (NRSs) involving children with epilepsy treated with cannabis-based products. We searched MEDLINE, Embase, PsycINFO, Cochrane Library, and gray literature (April 25, 2018). Read More

View Article
December 2018
2 Reads

Cannabidiol's Upregulation of -acyl Ethanolamines in the Central Nervous System Requires -acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Cannabis Cannabinoid Res 2018 30;3(1):228-241. Epub 2018 Nov 30.

Program in Neuroscience, Indiana University Bloomington, Bloomington, Indiana.

Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are bioactive cannabinoids. We recently showed that acute THC administration drives region-dependent changes in the mouse brain lipidome. This study tested the hypothesis that cell lines representing cell types present in the central nervous system (CNS), neurons (N18 cells), astrocytes (C6 glioma cells), and microglia (BV2 cells) would respond differently to THC, CBD, or their combination. Read More

View Article
November 2018

Evidence of a Causal Relationship Between Smoking Tobacco and Schizophrenia Spectrum Disorders.

Front Psychiatry 2018 20;9:607. Epub 2018 Nov 20.

Center for Life Course Health Research, University of Oulu, Oulu, Finland.

There has been emerging evidence of an association between tobacco smoking and schizophrenia spectrum disorders (SSD). Two meta-analyses have reported that people who smoke tobacco have an ~2-fold increased risk of incident schizophrenia or psychosis, even after adjusting for confounding factors. This study aimed to critically appraise the research which has examined the association between tobacco smoking and SSD against the Bradford Hill criteria for causality, to determine the strength of the evidence for a causal relationship. Read More

View Article
November 2018
1 Read

Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression.

Front Mol Neurosci 2018 20;11:424. Epub 2018 Nov 20.

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy.

The endocannabinoid system (ECS) has been recently recognized as a prominent promoter of the emotional homeostasis, mediating the effects of different environmental signals including rewarding and stressing stimuli. The ECS modulates the rewarding effects of environmental stimuli, influencing synaptic transmission in the dopaminergic projections to the limbic system, and mediates the neurophysiological and behavioral consequences of stress. Notably, the individual psychosocial context is another key element modulating the activity of the ECS. Read More

View Article
November 2018
5 Reads

Potential of an Interactive Drug Prevention Mobile Phone App (Once Upon a High): Questionnaire Study Among Students.

JMIR Serious Games 2018 Dec 4;6(4):e19. Epub 2018 Dec 4.

Institute of Psychology, Eötvös Loránd University, Budapest, Hungary.

Background: In recent years, drug prevention networks and drug education programs have started using Web-based or mobile phone apps as novel prevention tools, testing their efficacy compared with face-to-face prevention.

Objective: The aim of this study was to assess the potential of an interactive app called Once Upon a High (VoltEgySzer).

Methods: The app approaches drug prevention from 6 different aspects, and it addresses youngsters with 6 different modules: (1) interactive comics/cartoons, telling stories of recovery; (2) quiz game; (3) roleplay game; (4) introduction of psychoactive drugs; (5) information on the somatic and psychological effects of psychoactive substances; (6) list of available treatment units, rehabs, and self-support groups in Hungary. Read More

View Article
December 2018

Wastewater-based monitoring of illicit drug consumption in Istanbul: Preliminary results from two districts.

Sci Total Environ 2018 Nov 24;656:231-238. Epub 2018 Nov 24.

Istanbul University-Cerrahpasa, Institute of Forensic Sciences, Department of Medicine, 34098 Cerrahpasa, Istanbul, Turkey.

Wastewater-based epidemiology is a well-established and complementary approach for monitoring illicit drug use in the general population. In this study, amphetamine (AMP), methamphetamine (METH), 3,4-methylenedioxymethamphetamine (MDMA), cocaine (COC) (from benzoylecgonine), and cannabis (from THC-COOH) consumption levels were investigated for the first time in Turkey (Istanbul). A solid-phase extraction method was applied to influent wastewater samples collected from two districts, Beyoglu and Catalca. Read More

View Article
November 2018

Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco.

Drug Alcohol Depend 2018 Nov 26;194:468-475. Epub 2018 Nov 26.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA; Department of Medicine, Division of General Internal Medicine, Duke University Medical Center, Durham, NC, USA; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA; Center for Child and Family Policy, Sanford School of Public Policy, Duke University, Durham, NC, USA. Electronic address:

Background: Current data suggest that opioid misuse or opioid use disorder (OUD) may be over represented among tobacco users. However, this association remains understudied in primary care settings. A better understanding of the extent of heterogeneity in opioid misuse among primary care patients who use tobacco may have implications for improved primary care-based screening, prevention, and intervention approaches. Read More

View Article
November 2018
1 Read

Association Between Socio-Demographic and Health Functioning Variables Among Patients with Opioid Use Disorder Introduced by Prescription: A Prospective Cohort Study.

Pain Physician 2018 Nov;21(6):E623-E632

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada; Population Genomic Program, Chanchalani Research Centre, McMaster University, Hamilton, Canada; Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Canada; Peter Boris Centre for Addictions Research, Canada.

Background: Prescription opioid misuse in Canada has become a serious public health concern and has contributed to Canada's opioid crisis. There are thousands of Canadians who are currently receiving treatment for opioid use disorder, which is a chronic relapsing disorder with enormous impact on individuals and society.

Objectives: The aim of this study was to compare the clinical and demographic differences between cohorts of patients who were introduced to opioids through a prescription and those introduced to opioids for non-medical purposes. Read More

View Article
November 2018

Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal.

Mult Scler Relat Disord 2018 Nov 20;27:383-390. Epub 2018 Nov 20.

Department of Neurology, University of Colorado School of Medicine, 12700 East 19th Ave, B182, Aurora, CO 80045, United States. Electronic address:

Background: Studies suggest cannabis may improve symptoms like pain and muscle spasticity in patients with multiple sclerosis (PwMS). Despite cannabis' new-found legality and availability, few studies have explored the profile of PwMS cannabis users and characteristics of their use, particularly in a state where cannabis is legal both for recreational and medicinal use. The purpose of the current study was to evaluate cannabis use among PwMS at a large academic multiple sclerosis (MS) clinic, specifically: (1) prevalence, (2) products used (e. Read More

View Article
November 2018
2 Reads

Sex differences in the cardiometabolic health of cannabis users with a psychotic illness.

Drug Alcohol Depend 2018 Nov 22;194:447-452. Epub 2018 Nov 22.

Neuropsychiatric Epidemiology Research Unit, Division of Psychiatry, Medical School, University of Western Australia, Perth, Australia; Centre for Clinical Research in Neuropsychiatry, Division of Psychiatry, Medical School, University of Western Australia, Perth, Australia.

Background: Growing evidence shows cannabis use is associated with lower rates of metabolic dysregulation. Despite cannabis impacting each sex differently, few studies have examined the metabolic profile of male and female cannabis users separately. Our aim was to investigate sex differences in the impact of cannabis use on metabolic syndrome in adults with psychotic illness. Read More

View Article
November 2018

Change in alcohol and other drug use during five years of continuous opioid substitution treatment.

Drug Alcohol Depend 2018 Nov 26;194:438-446. Epub 2018 Nov 26.

King's College London, Addictions Department, Box 48, Institute of Psychiatry, Psychology and Neuroscience, DeCrespigny Park, Denmark Hill, London SE5 8AF, United Kingdom; Alcohol, Drugs, Tobacco and Justice Division, Health Improvement Directorate, Public Health England, 7th Floor Wellington House, 133-155 Waterloo Road, London SE1 8UG, United Kingdom. Electronic address:

Background: English national prospective, observational cohort study of patients continuously enrolled for five years in opioid substitution treatment (OST) with oral methadone and sublingual buprenorphine. This is a secondary outcome analysis of change in use of alcohol and other drug use (AOD) following identification of heroin use trajectories during OST.

Methods: All adults admitted to community OST in 2008/09 and enrolled to 2013/14 (n = 7717). Read More

View Article
November 2018
3 Reads

Mental health functioning and severity of cannabis withdrawal among medical cannabis users with chronic pain.

Drug Alcohol Depend 2018 Nov 6;194:401-409. Epub 2018 Nov 6.

Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States; Center for Clinical Management Research, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, United States.

Purpose: To describe patterns of cannabis withdrawal among a large sample of those who use medical cannabis and test the association between withdrawal symptomology and functioning.

Procedures: Adults ages 21 and older (N = 801) who were seeking medical cannabis certification (either for the first time or as a renewal) for chronic pain at medical cannabis clinics in southern Michigan completed baseline measures of cannabis use, withdrawal symptomology, functioning and other related constructs. Patients were included in the current study if they endorsed using cannabis at least weekly over the past three months. Read More

View Article
November 2018
1 Read

Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity.

Food Funct 2018 Nov 30. Epub 2018 Nov 30.

College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.

Three new stilbenoids (1-3) and 16 known stilbenoids (4-6) and cannabinoids (7-19) were isolated from the leaves of hemp (Cannabis sativa L.). The structures of the three new compounds were identified as α,α'-dihydro-3',4,5'-trihydroxy-4'-methoxy-3-isopentenylstilbene (HM1), α,α'-dihydro-3,4',5-trihydroxy-4-methoxy-2,6-diisopentenylstilbene (HM2), and α,α'-dihydro-3',4,5'-trihydroxy-4'-methoxy-2',3-diisopentenylstilbene (HM3) by 1D and 2D NMR spectroscopy, LC-MS, and HRESIMS. Read More

View Article
November 2018
1 Read
2.791 Impact Factor

Oral Ingestion of : Risks, Benefits, and Effects on Malaria-Infected Hosts.

Cannabis Cannabinoid Res 2018 26;3(1):219-227. Epub 2018 Nov 26.

Malaria Research Laboratories, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.

The emergence of a multidrug-resistant strain of () raises concern about malaria control strategies. Unfortunately, the role(s) of natural plants/remedies in curtailing malaria catastrophe remains uncertain. The claims of potential antimalarial activity of have not been well established nor the consequences defined. Read More

View Article
November 2018
3 Reads

Examining links between cannabis potency and mental and physical health outcomes.

Behav Res Ther 2018 Nov 17. Epub 2018 Nov 17.

Department of Psychology, Colorado State University, USA.

Cannabis use is associated with unwanted health outcomes, including anxiety, depression, poor sleep hygiene, and disrupted cognitive functioning. However, research to date has not been able to disentangle the complexities of these relations, leaving behavioral health service providers lacking clear direction for treatment. A limiting factor may be the common practices for cannabis use assessment. Read More

View Article
November 2018
5 Reads

Reefer madness or real medicine? A plea for incorporating medicinal cannabis in pharmacy curricula.

Curr Pharm Teach Learn 2018 Sep 7;10(9):1165-1167. Epub 2018 Jul 7.

Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, United States. Electronic address:

Introduction: Over the past twenty years, the acceptance and use of medicinal cannabis has increased in the United States. However, there is still a lack of education and comfort as it relates to the therapeutic uses of botanical cannabis and cannabidiol in pharmacy professional curricula. Professional training programs have failed to keep pace with the evolving national landscape and growing acceptance of this therapy. Read More

View Article
September 2018
1 Read

Cannabidiolic Acid-Mediated Interference with AP-1 Transcriptional Activity in MDA-MB-231 Breast Cancer Cells.

Nat Prod Commun 2017 May;12(5):759-761

We reported that cannabidiolic acid (CBDA), a non-psychotropic constituent of fiber-type cannabis plants, down-regulates the mRNA expression of cyclooxygenase-2 (COX-2) in highly aggressive MDA-MB-231 human breast cancer cells. However, the molecular mechanism(s) underlying the CBDA suppression of COX-2 have not yet been elucidated in detail. In MDA-MB-231 cells, COX-2 expression is known to be tightly regulated by the transcriptional activity of activator protein-I (AP-1), which is composed of a heterodimer of c-Fos and c-Jun. Read More

View Article

Spanish adaptation and validation of the Barratt Impulsiveness Scale for early adolescents (BIS-11-A).

Int J Clin Health Psychol 2015 Sep-Dec;15(3):274-282. Epub 2015 Aug 8.

Universidad de Oviedo, Spain.

Impulsivity has been associated with several psychiatric disorders such as substance abuse. The Barratt Impulsiveness Scale (BIS-11) is one of the most commonly administered self-reports for the assessment of impulsiveness in both research and clinical settings. There is a version for adolescents called BIS-11-A, which has not been yet properly adapted to Spanish population. Read More

View Article

Quantitative analysis of opioids and cannabinoids in wastewater samples.

Forensic Sci Res 2017 30;2(1):18-25. Epub 2017 Jan 30.

Department of Sciences, John Jay College of Criminal Justice, City University of New York, New York, NY, USA.

Wastewater-based epidemiology is an innovative approach that uses the analysis of human excretion products in wastewater to obtain information about exposure to drugs in defined population groups. We developed and validated an analytical method for the simultaneous determination of opioids (morphine, oxycodone, hydrocodone, oxymorphone and hydromorphone), and cannabinoids (Δ-tetrahydrocannabinol, 11--9-carboxy-tetrahydrocannabinol (THCCOOH) and THCCOOH-glucuronide) in raw-influent wastewater samples by ultra-high performance liquid chromatography-tandem mass spectrometry. Method validation included linearity (5-1 000 ng/L for opioids, 10-1 000 ng/L for cannabinoids), imprecision (<21. Read More

View Article
January 2017

Spiritual belief and its link with potentially addictive behaviors in a youth sample in Switzerland.

Int J Adolesc Med Health 2018 Nov 29. Epub 2018 Nov 29.

Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, Lausanne 1010, Switzerland, Phone: +41 213 147 375, Fax: +41 213 147 373.

Background Earlier studies suggested a positive impact of spirituality on addictive disorders, but this effect has rarely been studied in a large adolescent and young adult population. Aim To examine the association between spiritual beliefs (general belief, the supporting role of spiritual belief, the critical role of spiritual belief) and potentially addictive behaviors (tobacco, alcohol, cannabis and other illegal drugs, excessive Internet use and gambling). Methods Data were collected using online self-report questionnaires among a sample of 5179 adolescents and young adults aged 15-24 years in post-mandatory education in Switzerland. Read More

View Article
November 2018

The Role of CB2 Receptor in the Recovery of Mice after Traumatic Brain Injury.

J Neurotrauma 2018 Nov 29. Epub 2018 Nov 29.

The Hebrew University of Jerusalem, Institute for Drug Research, Dept. of Pharmacology, Jerusalem, Israel ;

Cannabis is one of the most widely used plant drugs in the world today. In spite of the large number of scientific reports on medical marijuana there still exists much controversy surrounding its use and the potential for abuse due to the undesirable psychotropic effects. However, recent developments in medicinal chemistry of novel non-psychoactive synthetic cannabinoids have indicated that it is possible to separate some of the therapeutic effects from the psychoactivity. Read More

View Article
November 2018

Medical Cannabis for Older Patients.

Drugs Aging 2018 Nov 29. Epub 2018 Nov 29.

Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada.

Interest in the medicinal use of cannabis and cannabinoids is mounting worldwide. Fueled by enthusiastic media coverage, patients perceive cannabinoids as a natural remedy for many symptoms. Cannabinoid use is of particular interest for older individuals who may experience symptoms such as chronic pain, sleep disturbance, cancer-related symptoms and mood disorders, all of which are often poorly controlled by current drug treatments that may also incur medication-induced side effects. Read More

View Article
November 2018
1 Read

Polydrug use trajectories and differences in impulsivity among adolescents.

Int J Clin Health Psychol 2018 Sep-Dec;18(3):235-244. Epub 2018 Aug 22.

Department of Psychology, Universidad Loyola Andalucía, Spain.

: Although alcohol, tobacco and cannabis are the most widely consumed drugs, sparse data exist regarding polydrug use in adolescents and its relationship with impulsivity. This study aims to identify trajectories of polydrug use and analyze differences in impulsivity between them. : A total of 1,565 adolescents (54. Read More

View Article

Adult attention-deficit/hyperactivity disorder, risky substance use and substance use disorders: a follow-up study among young men.

Eur Arch Psychiatry Clin Neurosci 2018 Nov 27. Epub 2018 Nov 27.

La Source, School of Nursing Sciences, University of Applied Sciences and Arts, Western Switzerland, Lausanne, Switzerland.

We investigated whether adult attention-deficit/hyperactivity disorder (ADHD) predicts risky substance use and substance use disorders (SUDs), and its impact on the course of these problematic substance use patterns. Our sample included 4975 Swiss men (mean age 20 ± 1.2 years) who participated in the baseline and 15-month follow-up assessments of the Cohort Study on Substance Use Risk Factors. Read More

View Article
November 2018
1 Read

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Authors:
Raymond K Walters Renato Polimanti Emma C Johnson Jeanette N McClintick Mark J Adams Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Yi-Ling Chou Franziska Degenhardt Anna R Docherty Alexis C Edwards Pierre Fontanillas Jerome C Foo Louis Fox Josef Frank Ina Giegling Scott Gordon Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Stefan Herms Colin Hodgkinson Per Hoffmann Jouke Jan Hottenga Martin A Kennedy Mervi Alanne-Kinnunen Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen John F Pearson Roseann E Peterson Samuli Ripatti Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Sarah L Elson Mark A Frye Wolfgang Gäbel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Aarno Palotie Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie Witt Norbert Wodarz Peter Zill Daniel E Adkins Joseph M Boden Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz Sven Cichon E Jane Costello Harriet de Wit Nancy Diazgranados Danielle M Dick Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Andrew C Heath Victor Hesselbrock John K Hewitt Christian J Hopfer John Horwood William Iacono Eric O Johnson Jaakko A Kaprio Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Paul Lichtenstein Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik Magnusson Nicholas G Martin Sarah E Medland Grant W Montgomery Elliot C Nelson Markus M Nöthen Abraham A Palmer Nancy L Pedersen Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard Rose Dan Rujescu Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Joel Gelernter Howard J Edenberg Arpana Agrawal

Nat Neurosci 2018 Dec 26;21(12):1656-1669. Epub 2018 Nov 26.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Read More

View Article
December 2018
6 Reads

Validation of the Marijuana Effect Expectancies Questionnaire (MEEQ) in a Non-Clinical French-Speaking Adolescent Sample.

Psychol Belg 2016 Feb 2;56(1):23-41. Epub 2016 Feb 2.

Département de Criminologie, Université de Liège, Belgium.

Teenagers commonly use cannabis. Expectancies related to the effects of cannabis play an important role in its consumption and are frequently measured with the Marijuana Effect Expectancies Questionnaire (MEEQ). This study aims to assess the psychometric properties (factor structure, internal consistency reliability, criterion validity) of the French MEEQ. Read More

View Article
February 2016

Palmitic acid ester of tetrahydrocannabinol (THC) and palmitic acid diester of 11-hydroxy-THC - Unsuccessful search for additional THC metabolites in human body fluids and tissues.

Forensic Sci Int 2018 Nov 16;294:86-95. Epub 2018 Nov 16.

University Bonn, Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany. Electronic address:

Fatty acid conjugates of hydroxy-metabolites of tetrahydrocannabinol (THC) or cannabinol have already been reported as metabolites in rats. In the herein presented investigation, palmitic acid esters of THC and its primary metabolite 11-hydroxy-delta9-tetrahydrocannabinol (11-OH-THC) were synthesized using esterification with palmitic acid chloride. Structural elucidation of the products was conducted using nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography coupled to quadrupole time of flight mass spectrometry (LC-QToF-MS). Read More

View Article
November 2018
4 Reads

Cannabinoids, Chemical Senses, and Regulation of Feeding Behavior.

Chem Senses 2018 Nov 27. Epub 2018 Nov 27.

Department of Nutrition, Food Sciences and Gastronomy, Institute of Nutrition and Food Safety, University of Barcelona, Campus Torribera, Barcelona, Spain.

The herb Cannabis sativa has been traditionally used in many cultures and all over the world for thousands of years as medicine and recreation. However, because it was brought to the Western world in the late 19th century, its use has been a source of controversy with respect to its physiological effects as well as the generation of specific behaviors. In this regard, the CB1 receptor represents the most relevant target molecule of cannabinoid components on nervous system and whole-body energy homeostasis. Read More

View Article
November 2018

Data relating to the transcriptomes of human lung epithelial cells exposed to radon-emitting rock, tobacco smoke or cannabis smoke.

Data Brief 2018 Dec 5;21:1568-1572. Epub 2018 Nov 5.

Health Sciences North Research Institute, Sudbury, ON, Canada P3E 2H3.

Presented herein are RNA expression data linked to the exposure of human lung epithelial cells to either low dose radon-emitting rock, tobacco smoke or cannabis smoke. Two cell lines were used, one representing a 'normal' lung epithelial cell (BEAS-2B, derived from immortilized bronchial epithelial cells from a cadaver) and one representing a 'cancerous' lung epithelial cell (NCI-H1975, derived from a primary lung adenocarcinoma from a non-smoker). Control cells were cultured under standard conditions. Read More

View Article
December 2018

Self-Experiments with Psychoactive Substances: A Historical Perspective.

Handb Exp Pharmacol 2018 Nov 27. Epub 2018 Nov 27.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

The purpose of this chapter is to highlight the rich tradition of self-experiments (SEs) with psychoactive substances carried out by scientists and therapists for more than a century. Scientifically inspired controlled SEs dominated until the end of the twentieth century, when ethical requirements minimized controlled SEs and "wild" SEs expanded particularly with the emergence of new psychoactive substances. The review focuses on laughing gas (nitrous oxide), cannabis, cocaine, hallucinogens, entactogens, and dissociative hallucinogens. Read More

View Article
November 2018

Prescribing cannabis based drugs: response from NICE and Health Education England.

BMJ 2018 Nov 26;363:k4940. Epub 2018 Nov 26.

Knowledge for Healthcare, Health Education England, London, UK.

View Article
November 2018
1 Read

Cannabis based drugs: accessing information in Scotland.

Authors:
Annette E Thain

BMJ 2018 Nov 26;363:k4947. Epub 2018 Nov 26.

NHS Education for Scotland, Glasgow G3 8BW, UK.

View Article
November 2018

Cluster randomised controlled trial of an online intervention to prevent ecstasy and new psychoactive substance use among adolescents: final results and implications for implementation.

BMJ Open 2018 Nov 25;8(11):e020433. Epub 2018 Nov 25.

NHMRC Centre of Research Excellence in Mental Health and Substance Use, National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.

Objectives: To evaluate the effectiveness of the online over 2 years, and examine the impact of intervention dose on outcomes.

Design: Cluster randomised controlled trial.

Setting: Secondary schools in Australia. Read More

View Article
November 2018
3 Reads

Cannabis Prevalence and National Drug Policy in 27 Countries: An Analysis of Adolescent Substance Use.

Int J Offender Ther Comp Criminol 2018 Nov 27:306624X18814184. Epub 2018 Nov 27.

2 University of Central Missouri, Warrensburg, USA.

Prior research that assesses the relationship between cannabis policy and prevalence rates has yielded mixed results, perhaps due to the varying rigor of these investigations. Addressing some of these issues in rigor and informed by a rational choice theory (RCT), we hypothesize that those policies on the more punitive end of McDonald and colleagues' classification will be most effective. Examining legislation in 27 countries utilizing the Second International Self-Report Delinquency Study (ISRD-2) through hierarchical linear modeling (HLM) models with both individual- and country-level controls, we find little support for these hypotheses. Read More

View Article
November 2018

Changes in Healthcare Encounter Rates Possibly Related to Cannabis or Alcohol following Legalization of Recreational Marijuana in a Safety-Net Hospital: An Interrupted Time Series Analysis.

J Addict Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Medicine, Division of Hospital Medicine, Denver Health Medical Center, Denver (SLC, AK, MLH); Department of Medicine, Division of General Internal Medicine (SLC); Department of Family Medicine (SLC); Department of Psychiatry (CJH); Department of Medicine, Division of Hospital Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (AK).

Objectives: Liberalization of marijuana laws in Colorado contributed to increases in cannabis-related adverse events over time. We examined characteristics of patients with healthcare encounters possibly related to cannabis and assessed the temporal association between legalization of recreational marijuana and healthcare encounters possibly attributed to cannabis.

Methods: Annual encounter rates possibly related to cannabis and alcohol were compared using negative binomial regression. Read More

View Article
November 2018
1 Read