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Mycopathologia 2021 Jun 12. Epub 2021 Jun 12.

Department of Parasitology, VMMU, Ha Dong, Ha Noi, Vietnam.

Introduction: Candida species is the most common cause of invasive fungal infection. With the wide variation in species distribution and antifungal susceptibility of causative agents, local epidemiological profiles are needed to provide effective guidelines for the treatment of invasive candidiasis.

Objective: To find out the species distribution and antifungal susceptibilities of Candida strains isolated from patients in an intensive care unit (ICU) of Vietnam. Read More

Clin Exp Immunol 2021 Jun 11. Epub 2021 Jun 11.

Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Signal transducer and activator of transcription (STAT)1 heterozygous gain-of-function (GOF) mutations are known to induce immune dysregulation and chronic mucocutaneous candidiasis (CMCC). Previous reports suggest an association between demodicosis and STAT1 GOF. However, immune characterization of these patients is lacking. Read More

Sex Transm Dis 2021 Mar 16. Epub 2021 Mar 16.

1Departments of Internal Medicine 2Biochemistry, Microbiology and Immunology Wayne State University School of Medicine Detroit, Michigan.

Background: Recurrence of bacterial vaginosis (RBV) is a major challenge to effective therapy. Women suffering from intractable and frequent recurrences are ill-served by available treatment options both antimicrobial and use of probiotics.

Methods: One hundred and five women with RBV failing all recommended regimens seen in clinic were prescribed combination oral nitroimidazole 500mg bid for 7 days and simultaneous boric acid 600mg daily per vagina therapy for 30 days, there after by twice weekly vaginal metronidazole gel for five months in attempt to prevent recurrence and followed by a 6-month observation period. Read More

Head Neck Pathol 2021 Jun 9. Epub 2021 Jun 9.

Department of Stomatology (Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Middle-aged and old adults (≥ 50 years) diagnosed with Cowden syndrome (CS) with orofacial manifestations are uncommon. We describe a case of CS in a 53-year-old female showing "narrow bird-like" face, macrocephaly, acral keratoses, oral candidiasis, burning in the mouth, and multiple asymptomatic papillomatous lesions with a cobblestone pattern distributed on the alveolar ridge, tongue, buccal mucosa, and commissure. The histopathological features of lesions of the oral mucosa were those of papillary fibroepithelial hyperplasia. Read More

J Pediatric Infect Dis Soc 2021 Jun 9. Epub 2021 Jun 9.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

Open Forum Infect Dis 2021 Jun 16;8(6):ofab250. Epub 2021 May 16.

Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Background: There are no clear criteria for antifungal de-escalation after initial empirical treatments. We hypothesized that early de-escalation (ED) (within 5 days) to fluconazole is safe in fluconazole-susceptible candidemia with controlled source of infection.

Methods: This is a multicenter post hoc study that included consecutive patients from 3 prospective candidemia cohorts (2007-2016). Read More

J Med Life 2021 Mar-Apr;14(2):250-256

Clinical Research Development Centre, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

This was a clinical trial study that aimed to investigate the efficacy of vaginal chlorhexidine gel in the treatment of vulvovaginal candidiasis, bacterial vaginosis, and nonspecific vaginitis. The study population included patients who complained of vaginal discharge and presented to our University Gynecology Clinic. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) software. Read More

BMC Oral Health 2021 Jun 8;21(1):292. Epub 2021 Jun 8.

Postgraduate Program in Pathology, School of Medicine, Universidade Federal Fluminense, Rio de Janeiro, Brazil.

Background: Secukinumab is a human monoclonal antibody immunoglobulin that neutralises interleukin (IL)-17A, and as such, is effective in the treatment of psoriasis. However, as IL-17A is essential in protection against fungal infections, patients treated with this drug may develop candidiasis. This report presents a case of atypical oral candidiasis occurring during targeted drug immunotherapy with an interleukin 17 (IL-17) inhibitor (secukinumab), with the aim of emphasisinge the necessity of periodical oral health assessment and monitoring. Read More

Med Mycol 2021 Jun 7. Epub 2021 Jun 7.

LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.

Whereas antisense oligomers (ASOs) have been successfully utilized to control gene expression, they have been little exploited to control Candida albicans virulence's determinants. Filamentation is an important virulence factor of C. albicans, and RAS1 and RIM101 genes are involved in its regulation. Read More

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211016964. Epub 2021 May 20.

Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Background: Oral candidiasis (OC) is an indirect indicator of cell-mediated immunodeficiency with a high predictive value of disseminated candidiasis. Here, we report the prevalence and factors associated with laboratory-confirmed OC in human immunodeficiency virus (HIV)-uninfected children with clinical OC attending the outpatient clinic or admitted in pediatric wards of the Bugando Medical Center (BMC).

Methods: A cross-sectional study was conducted between January and June 2017. Read More

Front Neurol 2021 20;12:679164. Epub 2021 May 20.

Department of Paediatrics, St Mary's Hospital, Kurume, Fukuoka, Japan.

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare autosomal recessive disorder caused by a mutation in the autoimmune regulator gene. Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy typically exhibit hypoparathyroidism, adrenocortical failure, and chronic mucocutaneous candidiasis. There are only a few case reports of autoimmune encephalitis during autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, but not as an initial manifestation. Read More

Rev Iberoam Micol 2021 Jun 3. Epub 2021 Jun 3.

Centro de Estudios Micológicos, Ciudad Autónoma de Buenos Aires, Argentina.

Background: Recurrent vulvovaginitis is a growing problem that affects millions of women worldwide. In many cases it is treated as vulvovaginal candidiasis, but there is not always microbiological confirmation.

Aims: To determine the etiology of vulvovaginitis in a group of patients. Read More

Wiad Lek 2021 ;74(5):1189-1195

SUMY STATE UNIVERSITY, SUMY, UKRAINE.

Objective: The aim: Is to determine the features of the HIV infection and changes in indicators of endogenous intoxication and immunoreactivity depending on the clinical stage and the level of CD4 lymphocytes.

Patients And Methods: Materials and methods: 72 HIV-patients were examined. Comparison group included 40 healthy blood donors. Read More

Res Microbiol 2021 Jun 2:103849. Epub 2021 Jun 2.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:

Co-infection with other microorganisms can promote the Candida albicans to be invasive. In this study, Escherichia coli and C. albicans were co-isolated from the women with candidiasis symptoms. Read More

Cell Microbiol 2021 Jun 3:e13371. Epub 2021 Jun 3.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage. Notably, the secretion of the hyphal toxin candidalysin is essential for both epithelial cell damage and activation of mucosal immune responses. Read More

Clin Case Rep 2021 May 24;9(5):e04322. Epub 2021 May 24.

Division of Hematology Department of Internal Medicine Cerrahpaşa Faculty of Medicine Istanbul University-Cerrahpaşa Istanbul Turkey.

Corticosteroids are commonly used in lymphoma patients, and findings in favor of esophageal involvement in 18F-FDG PET-CT should be considered suspicious and definitely be confirmed by biopsy. We describe a 58-year-old lady with diffuse large B-cell lymphoma and central nervous system involvement having an increased metabolism in the distal esophagus with 18F-FDG PET/CT, which was consistent with esophageal candidiasis, most probably due to prolonged use of dexamethasone. Esophageal candidiasis can be misdiagnosed as malignancy with a high SUVmax and may lead to difficulties while managing these patients. Read More

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):114

Department of Dermatology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India.

Iran J Med Sci 2021 May;46(3):207-217

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Oral candidiasis is a frequent form of candidiasis, caused by species, in particular, (). The transition of from yeast to hyphae allows its attachment to epithelial cells, followed by biofilm formation, invasion, and tissue damage. Hence, we investigated the effect of subspecies thermophilus () on the growth as well as biofilm and germ-tube formation of both and in vivo in a murine model. Read More

Mutat Res 2021 Jan-Jun;787:108361. Epub 2020 Dec 13.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria. Electronic address:

Approximately 165,000 and 311,000 individuals die annually from urothelial (UC) and cervical (CC) cancer. The therapeutic success of these cancers depends strongly on their early detection and could be improved by use of additional diagnostic tools. We evaluated the current knowledge of the use of micronucleus (MN) assays (which detect structural and numerical chromosomal aberrations) with urine- (UDC) and cervix-derived (CDC) cells for the identification of humans with increased risks and for the diagnosis of UC and CC. Read More

BMC Infect Dis 2021 Jun 3;21(1):523. Epub 2021 Jun 3.

Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.

Background: Vaginal candidiasis is frequent in women of reproductive age. Accurate identification Candida provides helpful information for successful therapy and epidemiology study; however, there are very limited data from the Vietnam have been reported. This study was performed to determine the prevalence, species distribution of yeast causing vaginal discharge and antifungal susceptibility patterns of Candida albicans among symptomatic non-pregnant women of reproductive age. Read More

Future Microbiol 2021 Jun 4;16:619-621. Epub 2021 Jun 4.

Department of Clinical Microbiology, La Paz University Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain.

Here, we present a case of off-label successful use of the T2 MR (T2Candida test) for the diagnosis of invasive candidiasis ( endolphthalmitis). This case demonstrates that T2Candida could be performed in sterile body fluids to improve microbiological diagnosis of invasive candidiasis. Read More

Aust N Z J Obstet Gynaecol 2021 Jun 3. Epub 2021 Jun 3.

School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia.

Recurrent vulvovaginal candidiasis (RVVC) is a subtype of vulvovaginal candidiasis, with debilitating effects on physical and emotional well-being affecting up to 10% of Australian women. Current evidence suggests that the induction and maintenance approach for RVVC is not particularly effective with post-treatment relapse rates as high as 57%. Frequently accessed Australasian RVVC prescribing resources and guidelines were examined showing a variety of adaptations of current evidence-based induction and maintenance therapies, making it difficult to select best treatment in clinical practice. Read More

Amino Acids 2021 Jun 3. Epub 2021 Jun 3.

Department of Pharmaceutical Technology and Biochemistry and BioTechMed Center, Gdańsk University of Technology, Gdańsk, Poland.

Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. Read More

Ital J Pediatr 2021 Jun 2;47(1):126. Epub 2021 Jun 2.

Endocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) or autoimmune polyglandular syndrome Type 1 is a rare autosomal recessive syndrome. The disorder is caused by mutations in the AIRE (AutoImmune Regulator) gene. According to the classic criteria, clinical diagnosis requires the presence of at least two of three main components: chronic mucocutaneous candidiasis, hypoparathyroidism and primary adrenal insufficiency. Read More

Quintessence Int 2021 Jun 2;0(0). Epub 2021 Jun 2.

Objective: Candida albicans in considered to be a marker of immunosuppression in serious chronic condition such as HIV and cancer patients on immunosuppresion medications. The new COVID-19 pandemic has caused acute respiratory distress syndrome in many patients, which poses a risk of super-infections including Candida strains causing oral candidiasis as well as invasive fungal infections. The aim of the study was to examine the association between COVID-19 and oral and general candidiasis. Read More

Pediatr Transplant 2021 Jun 2:e14048. Epub 2021 Jun 2.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

APS-1 is an extremely rare, autosomal recessive condition that often presents with candidiasis, adrenal insufficiency, and hypoparathyroidism. This condition is associated with autoimmune hepatitis in less than 20% of cases, and there have only been a few reports of children with the condition who developed ALF. We present a unique case of an infant with APS-1 who developed ALF and subsequently required liver transplantation. Read More

Int J Environ Res Public Health 2021 May 24;18(11). Epub 2021 May 24.

Department of Physiotherapy, Faculty of Health Sciences, Universidad Católica de Ávila, 05005 Ávila, Spain.

Purpose: To study the prevalence of UI in female athletes, the category of sports with the highest number of cases, the most incident risk factors and the bio-psycho-social consequences.

Methods: Preparation of a survey, based on two validated questionnaires answered by 63 participants, to carry out an analytical, transversal and observational study. All participants were European, adult, female athletes (mean age 30. Read More

Antibiotics (Basel) 2021 May 26;10(6). Epub 2021 May 26.

Centro de Química Estrutural (CQE), Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

Currently there is a gap between the rate of new antifungal development and the emergence of resistance among clinical strains, particularly threatened by the extreme adhesiveness of to indwelling medical devices. Two silver camphorimine complexes, [Ag(OH){OCHN(CH)NCHO}] (compound P) and [{Ag(OCHNCHCH-p)}(μ-O)] (compound Q), are herein demonstrated as having high inhibiting activity towards the growth of and clinical strains resistant to azoles, the frontline antifungals used in clinical practice. Compounds P and Q were also explored as bioactive coatings to prevent colonization by and colonize the surface of indwelling medical devices, resulting in persistent infections. Read More

Pharmaceutics 2021 May 27;13(6). Epub 2021 May 27.

Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania.

Thousands of microorganisms coexist within the human microbiota. However, certain conditions can predispose the organism to the overgrowth of specific pathogens that further lead to opportunistic infections. One of the most common such imbalances in the normal oral flora is the excessive growth of spp. Read More

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Dermatology, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.

The skin is the outermost layer of the body and is exposed to many environmental stimuli, which cause various inflammatory immune responses in the skin. Among them, fungi are common microorganisms that colonize the skin and cause cutaneous fungal diseases such as candidiasis and dermatophytosis. The skin exerts inflammatory responses to eliminate these fungi through the cooperation of skin-component immune cells. Read More