Control of mucosal candidiasis in the zebrafish swimbladder depends on neutrophils that block filament invasion and drive extracellular trap production.
Infect Immun 2017 Jun 12. Epub 2017 Jun 12.
Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, USA
Candida albicans is a ubiquitous mucosal commensal that is normally prevented from causing acute or chronic invasive disease. Neutrophils contribute to protection in oral infection but exacerbate vulvovaginal candidiasis. To dissect the role of neutrophils during mucosal candidiasis we took advantage of a new, transparent zebrafish swimbladder infection model. Read More