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    1947 results match your criteria Candidiasis Cutaneous

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    Verrucous Plaque With Unusually Large Candida Blastoconidia: A Unique Clinicopathological Presentation of Systemic Mucocutaneous Candidiasis.
    Am J Dermatopathol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Pathology, Hospital Clínico Universitario/INCLIVA, University of Valencia, Valencia, Spain.
    Mucocutaneous candidiasis is a common infection affecting both immunocompetent and immunosuppressed individuals. Diversity in the clinical and histopathological presentation of mucocutaneous candidiasis is well known. However, the occurrence of cutaneous verrucous lesions and giant yeast-like structures has been rarely reported. Read More

    Antifungal Activity of Eugenol Loaded Electrospun PAN Nanofiber Mats against Candida Albicans.
    Curr Drug Deliv 2018 Feb 26. Epub 2018 Feb 26.
    Department of Textile Engineering, Isfahan University of Technology, Isfahan 84156-83111. Iran.
    Eugenol, as the major phenolic component of clove essential oil due to its desired properties in medical field, was loaded into polyacrylonitrile (PAN) nanofibers with various percentages. Our main purpose in this study was to determine the in vitro antifungal activity of eugenol loaded on PAN nanofibers against Candida albicans as the most common causative agent for candidiasis. Also, the surface morphology and the mechanical properties of nanofibers were studied by scanning electron microscope (SEM) and a tensile tester, respectively. Read More

    Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets.
    Mil Med 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand.
    Background: Superficial fungal foot infection is one of the most important dermatological diseases currently affecting military personnel. Many Thai naval rating cadets are found to suffer from superficial fungal foot infections and their sequels.

    Objective: To investigate prevalence, potent risk factors, responding pathogens and clinical correlation of superficial fungal foot infection in Thai naval rating cadets training in Naval rating school, Sattahip, Thailand. Read More

    Experimental in Vivo Models of Candidiasis.
    J Fungi (Basel) 2018 Feb 6;4(1). Epub 2018 Feb 6.
    Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
    Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus . infections are among the most common human mycoses. species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. Read More

    Burden of Serious Fungal Infections in Jordan.
    J Fungi (Basel) 2018 Jan 18;4(1). Epub 2018 Jan 18.
    Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M23 9LT, UK.
    Objective: To estimate the burden of fungal infections in Jordan for the first time.

    Material And Methods: Population data was from UN 2011 statistics and TB cases from WHO in 2012. Fewer than 100 patients with HIV were recorded in Jordan in 2013. Read More

    antifungal activity of essential oils extracted from plants against fluconazole-susceptible and -resistant .
    Curr Med Mycol 2017 Jun;3(2):1-6
    Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.
    Background And Purpose: is the most common cause of candidal infections. Various studies have shown drug resistance among isolates; thus, it is necessary to discover replacement treatments for infections. In this study, we aimed to compare the effects of different essential oils against azoles-resistant and azoles-susceptible isolates. Read More

    Quantitation of ergosterol content and gene expression profile of gene in fluconazole-resistant .
    Curr Med Mycol 2017 Mar;3(1):13-19
    Department of Microbiology, Yasooj Branch, Islamic Azad University, Yasooj, Iran.
    Background And Purpose: The frequency of opportunistic fungal infections in immunocompromised patientsespecially by species has sharply increased in the last few decades. The objective of this study was to analyse the ergosterol content and gene expression profiling of clinical isolates of fluconazole-resistant

    Materials And Methods: Sixty clinical samples were identified and collected from immunocompromised patients, namely recurrent oral, vaginal, and cutaneous candidiasis, during 2015-16. Antifungal susceptibility testing of fluconazole against clinical species was performed according to Clinical and Laboratory Standards Institute guidelines. Read More

    Microbial Evaluation in Capsular Contracture of Breast Implants.
    Plast Reconstr Surg 2018 01;141(1):23-30
    Naples, Italy From the Department of Plastic, Reconstructive and Aesthetic Surgery, the Department of Experimental Medicine, Section of Virology and Microbiology, Università della Campania Luigi Vanvitelli; the Unit of Plastic, Reconstructive and Aesthetic Surgery, Università Federico II; and the Department of Public Health.
    Background: Capsular contracture around breast implants is a severe and unpredictable complication experienced by up to 50 percent of patients after breast augmentation and reconstruction, and represents a major cause leading to reoperation. Several lines of evidence point to the involvement of subclinical infections and of bacterial biofilm formation.

    Methods: To reduce the incidence of capsular contracture following mammaplasty, the authors studied the correlation between contamination by exogenous and endogenous bacterial flora and the capacity to develop bacterial biofilm in mammary implants. Read More

    Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis.
    Acta Dermatovenerol Croat 2017 Oct;25(3):248-250
    Prof. Romana Čeović, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine, University of Zagreb, 10000 Zagreb, Šalata 4, Croatia;
    Dear Editor, the association between lymphomas and autoimmune manifestations, as well as the prevalence of the cases of coexistent lymphomas and autoimmune conditions, has not been completely established (1-3). Since cutaneous T-cell lymphoma (CTCL) cases are rare, any hypothesis can only be based on case reports or small case series. We present the case of a male patient with folliculotropic mycosis fungoides (FMF) and synchronous autoimmune hepatitis (AIH) with extremely high levels of cancer antigen 19-9 (CA 19-9). Read More

    Effect of 1064-nm Q-switched Nd:YAG laser on invasiveness and innate immune response in keratinocytes infected with Candida albicans.
    Lasers Med Sci 2017 Dec 14. Epub 2017 Dec 14.
    Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania "Luigi Vanvitelli", Naples, Italy.
    Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal side effects. Read More

    Risks of Ruxolitinib in Gain-of-Function-Associated Severe Fungal Disease.
    Open Forum Infect Dis 2017 22;4(4):ofx202. Epub 2017 Sep 22.
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Immunology, National Institutes of Health, Bethesda, Maryland.
    Heterozygous gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 GOF patients with severe invasive or cutaneous fungal infections. Read More

    Luliconazole, a new antifungal against Candida species isolated from different sources.
    J Mycol Med 2017 Nov 29. Epub 2017 Nov 29.
    Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Golestan BLV, Ahvaz, Iran. Electronic address:
    Objective: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review.
    Mycopathologia 2018 Apr 22;183(2):417-421. Epub 2017 Nov 22.
    Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou, 310014, Zhejiang, China.
    The incidence of candidiasis due to non-albicans Candida species (especially Candida glabrata) has significantly increased in recent decades. Candida glabrata often invades immunocompromised hosts and causes systemic or mucosal infections, whereas cutaneous infections are rarely reported. We present a rare case of cutaneous infection caused by C. Read More

    Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions.
    J Cytol 2017 Oct-Dec;34(4):179-182
    Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
    Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections.

    Materials And Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). Read More

    Cutaneous Candidiasis in a Gottingen Minipig: A Potential Pitfall in Preclinical Studies.
    Toxicol Pathol 2017 Dec 20;45(8):1032-1034. Epub 2017 Sep 20.
    3 Toxicologic Pathology, Sackler School of Medicine, Tel Aviv University, Timrat, Israel.
    The Göttingen minipig is often used in preclinical toxicity studies. Therefore, knowledge of spontaneously occurring pathologies is important to differentiate them from test drug-related effects. We report on a Göttingen minipig, which developed exudating widespread dermatitis during a preclinical toxicity study with a subcutaneously injected drug. Read More

    Acute disseminated candidiasis with skin lesions: a systematic review.
    Clin Microbiol Infect 2018 Mar 25;24(3):246-250. Epub 2017 Aug 25.
    University Hospital, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:
    Background: Neutropenic patients developing acute disseminated candidiasis may present with skin lesions.

    Aims: To evaluate the epidemiology of acute disseminated candidiasis with skin lesions in neutropenic patients, taking into consideration changes caused by different prophylactic strategies.

    Sources: A systematic review of English-language articles found via PubMed (1963-2016) was performed. Read More

    Use of cost effective and rapid molecular tools for identification of species, opportunistic pathogens.
    Curr Med Mycol 2016 Sep;2(3):1-4
    Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
    Background And Purpose: Candidiasis is a widespread fungal infection caused by different species. Rapid identification of species in clinical laboratory is becoming increasingly important since the identification and discrimination of ethological agents for early treatment. We aimed at molecular identification of commonly species isolated from clinical samples by using both PCR-RFLP assay and amplification of hwp1 gene. Read More

    Infection and tissue repair of experimental cutaneous candidiasis in diabetic mice.
    J Med Microbiol 2017 Jun 13;66(6):808-815. Epub 2017 Jun 13.
    1​Department of Pathological Sciences, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380 - 86057-970, Londrina, PR, Brazil.
    Purpose: Diabetic patients seem to be predisposed to cutaneous candidiasis. In this study, we evaluated the interference of diabetic conditions in alloxan-induced diabetic mice in relation to the development of C. albicans infection, density of M1 and M2 macrophages, distribution of collagen type I and III and anti-inflamamatory cytokines involved in tissue repair. Read More

    Disseminated Cutaneous Trichosporonosis in an Adult Bone Marrow Transplant Patient.
    Indian Dermatol Online J 2017 May-Jun;8(3):192-194
    Department of Dermatology, National University Health System, Singapore.
    The species are yeast-like opportunistic pathogens in immunocompromised patients. infections have been reported in pediatric bone marrow transplant (BMT) patients. However, its incidence is low in the adult literature. Read More

    Influence of low-level laser on pain and inflammation in type 2 diabetes mellitus with diabetic dermopathy - A case report.
    J Cosmet Laser Ther 2017 Oct 11;19(6):360-363. Epub 2017 May 11.
    a Kasturba Medical College (KMC), Manipal University , Manipal , India.
    Numerous skin lesions have been commonly observed in individuals with diabetes mellitus. The common skin manifestations of diabetes mellitus are erythrasma, xanthomatosis, xanthelasma, phycomycetes and cutaneous infections like furuncolosis, candidiasis, carbuncle, dermatophytosis, etc. Diabetic dermopathy is the most common skin lesion found in patients with diabetes. Read More

    Effect of long-term exposure of mice to 900 MHz GSM radiation on experimental cutaneous candidiasis.
    Saudi J Biol Sci 2017 May 2;24(4):907-914. Epub 2016 Jan 2.
    Department of Pathobiology, Faculty of Veterinary Specialized Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran.
    Mobile phones communicate with base stations using 900 MHz microwaves. The current study was aimed to survey the effects of long-term 900 MHz microwave exposure of mice on experimentally induced cutaneous candidiasis. Forty inbred, male, BALB/c mice were randomly divided into four groups. Read More

    Differential Diagnosis of Diaper Dermatitis.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):16S-22S
    1 Johns Hopkins Children's Center, Baltimore, MD, USA.
    Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Read More

    Preventive effects of topical washing with miconazole nitrate-containing soap to diaper candidiasis in hospitalized elderly patients: A prospective, double-blind, placebo-controlled study.
    J Dermatol 2017 Jul 22;44(7):760-766. Epub 2017 Feb 22.
    Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
    The objective of the present randomized, double-blind trial was to evaluate the efficacy and safety of daily washing with miconazole nitrate-containing soap for candidiasis at diaper-covered sites in elderly subjects under long-term inpatient care. To confirm the onset and disappearance of candidiasis, we microscopically evaluated the existence of the pseudohyphae and/or blastoconidia of Candida spp. We enrolled 75 elderly patients who wore diapers all day in the hospital or nursing home. Read More

    Common Skin Conditions in Children: Skin Infections.
    FP Essent 2017 Feb;453:26-32
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Effect of econazole and benzydamine on sensory neurons in culture.
    J Physiol Pharmacol 2016 Dec;67(6):851-858
    Institute of Molecular and Cell Biology, Miguel Hernandez University, Alicante, Spain.
    Econazole is an anti-mycotic agent widely used for the treatment of cutaneous fungal infections, and for the therapy of vaginal candidiasis. Topical application of this azole is generally safe, although some patients have complained of mild burning sensation/cutaneous irritation and itching, especially when administered intravaginally. The underlying mechanisms responsible of these adverse effects are poorly understood, though they suggest excitation of cutaneous nociceptor terminals. Read More

    Serious fungal infections in Pakistan.
    Eur J Clin Microbiol Infect Dis 2017 Jun 4;36(6):949-956. Epub 2017 Feb 4.
    Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
    The true burden of fungal infection in Pakistan is unknown. High-risk populations for fungal infections [tuberculosis (TB), diabetes, chronic respiratory diseases, asthma, cancer, transplant and human immunodeficiency virus (HIV) infection] are numerous. Here, we estimate the burden of fungal infections to highlight their public health significance. Read More

    Congenital Cutaneous Candidiasis: Prompt Systemic Treatment Is Associated With Improved Outcomes in Neonates.
    Clin Infect Dis 2017 May;64(10):1387-1395
    Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.
    Background: Congenital cutaneous candidiasis (CCC) is a challenging diagnosis due to various rash presentations. Inadequate early treatment is associated with high rates of dissemination and death. The effects of early diagnosis, dermatologic presentation, and antifungal treatment on outcomes are lacking. Read More

    Vegetating Candidiasis: A Mimicker of Squamous Cell Carcinoma in Keratitis Ichthyosis Deafness Syndrome.
    Pediatr Dermatol 2017 Mar 23;34(2):201-203. Epub 2017 Jan 23.
    Department of Dermatology, Instituto Nacional de Salud del Niño, Sede Breña, Lima, Peru.
    Keratitis ichthyosis deafness (KID) syndrome is a rare genodermatosis with a high risk of cutaneous malignancy and infections. Infections can induce pseudocarcinomatous epidermal hyperplasia, leading to erroneous diagnosis of squamous cell carcinoma. We present a pediatric case of KID syndrome with vegetating plantar and acral candidiasis and highlight the importance of correct biopsy technique and clinicopathologic correlation in appropriate management. Read More

    [Trichophyton tonsurans associated with non-albicans Candida species in hands onychomycosis about a Moroccan case].
    J Mycol Med 2017 Mar 29;27(1):119-123. Epub 2016 Dec 29.
    Laboratoire de parasitologie-mycologie, hôpital militaire Moulay Ismaïl, boulevard Mohamed, El Hansali, Meknès 50000, Maroc.
    Introduction: Trichophyton tonsurans is an anthropophilic dermatophyte, frequent in the USA and in Asia where it is responsible for causing tinea capitis. At present, we attend an emergence of this species in certain regions where it was not or little met. Here, we report a case of onychomycosis of the hand due to T. Read More

    New perspectives in the topical delivery of optimized amphotericin B loaded nanoemulsions using excipients with innate anti-fungal activities: A mechanistic and histopathological investigation.
    Nanomedicine 2017 04 20;13(3):1117-1126. Epub 2016 Dec 20.
    Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
    This study aimed to develop nanoemulsions (NEs) for the topical delivery of Amphotericin B using lipids and surfactants with innate antifungal activity. NEs were formulated by a slow spontaneous titration method and characterized for particle size, polydispersity index, zeta potential, zone of inhibition (ZOI), in vitro release, enhanced ex vivo rat skin permeation-deposition, hemolysis followed by interaction with the skin using scanning electron microscopy, and histopathology. The ZOI values of the optimized NEs (ANE3) were 21. Read More

    Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls.
    J Eur Acad Dermatol Venereol 2017 May 9;31(5):887-893. Epub 2017 Jan 9.
    Department of Odontology, Oral Pathology and Oral Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
    Background: Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology affecting the skin and oral mucosa. Oral lichenoid lesions (OLLs), like oral contact reactions, may resemble oral lichen planus (OLP) both clinically and histopathologically. As OLP and OLL are hyperkeratotic diseases and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in these lesions. Read More

    Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency.
    Proc Natl Acad Sci U S A 2016 12 7;113(51):E8277-E8285. Epub 2016 Dec 7.
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, 75015 Paris, France;
    Chronic mucocutaneous candidiasis (CMC) is defined as recurrent or persistent infection of the skin, nails, and/or mucosae with commensal Candida species. The first genetic etiology of isolated CMC-autosomal recessive (AR) IL-17 receptor A (IL-17RA) deficiency-was reported in 2011, in a single patient. We report here 21 patients with complete AR IL-17RA deficiency, including this first patient. Read More

    Fabrication of anti-vitiligo ointment containing : in vitro and in vivo characterization.
    Drug Des Devel Ther 2016 22;10:3805-3816. Epub 2016 Nov 22.
    Faculty of Pharmacy, Gomal University, D.I.Khan, Pakistan.
    Background: Vitiligo is a repugnant and odious dermatological malady of the time. It has an detrimental impact on the pigmentation of the human skin as a result of the destruction of cutaneous melanocytes. It affects 1%-2% of the population worldwide. Read More

    Hydroxychavicol: A phytochemical targeting cutaneous fungal infections.
    Sci Rep 2016 Nov 29;6:37867. Epub 2016 Nov 29.
    Clinical Microbiology Division, Indian Institute of Integrative Medicine, Jammu Tawi-180 001, India.
    The present study was designed to investigate the potency of hydroxychavicol on selected cutaneous human pathogenic fungi by the use of in vitro and in vivo assays and mechanistic characterization along with toxicological effects. Hydroxychavicol consistently displayed a fungicidal effect against all fungal species tested. Inoculum concentrations over the range of 10 to 10 CFU/ml did not significantly alter its antifungal potential and time-kill curve results revealed concentration-dependent killing. Read More

    A clinical study of cutaneous changes in pregnancy.
    J Epidemiol Glob Health 2017 Mar 19;7(1):63-70. Epub 2016 Nov 19.
    Department of Dermatology, Government Medical College, Alappuzha, Kerala, India.
    Background/objective: Pregnant women experience a myriad of physiological and metabolic changes that affect different organ systems in the body. Cutaneous and appendageal alterations that manifest during pregnancy are largely modulated by hormonal, immunologic, and metabolic factors. Detailed reports encompassing physiological changes and specific dermatoses of pregnancy and effects of various dermatoses on pregnant women are scanty in literature. Read More

    Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies.
    Int J Nanomedicine 2016;11:5531-5547. Epub 2016 Oct 25.
    Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University.
    Terconazole (Tr) is the first marketed, most active triazole for vaginal candidiasis. Owing to poor skin permeation and challenging physicochemical properties, Tr was not employed for the treatment of cutaneous candidiasis. This is the first study to investigate the relevance of novel lecithin-integrated liquid crystalline nano-organogels (LCGs) to improve physicochemical characteristics of Tr in order to enable its dermal application in skin candidiasis. Read More

    Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
    J Exp Med 2016 Oct 19;213(11):2413-2435. Epub 2016 Sep 19.
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, 75015 Paris, France.
    Combined immunodeficiency (CID) refers to inborn errors of human T cells that also affect B cells because of the T cell deficit or an additional B cell-intrinsic deficit. In this study, we report six patients from three unrelated families with biallelic loss-of-function mutations in RLTPR, the mouse orthologue of which is essential for CD28 signaling. The patients have cutaneous and pulmonary allergy, as well as a variety of bacterial and fungal infectious diseases, including invasive tuberculosis and mucocutaneous candidiasis. Read More

    Fournier Gangrene Caused by Candida albicans in an Infant After Cardiac Surgery.
    Mycopathologia 2017 Apr 2;182(3-4):409-412. Epub 2016 Nov 2.
    Department of Pediatric Cardiac Surgery, Copernicus Hospital in Gdansk, Al. Jana Pawla II 50, 80-462, Gdansk, Poland.
    Fournier gangrene is a rare, rapidly progressive, life-threatening condition. We report a 23-day-old boy with pulmonary atresia and ventricular septal defect treated surgically, who developed Fournier gangrene. Emergency surgery was performed with tissue sampling for microbiological examination. Read More

    STAT mutations as program switchers: turning primary immunodeficiencies into autoimmune diseases.
    J Leukoc Biol 2017 01 1;101(1):29-38. Epub 2016 Nov 1.
    Department of Clinical and Experimental Sciences, Institute of Molecular Medicine "Angelo Nocivelli," University of Brescia, Brescia, Italy; and
    STAT proteins are a family of transcription factors that mediate cellular response to cytokines and growth factors. Study of patients with familial susceptibility to pathogens and/or autoimmune diseases has led to the identification of 7 inherited disorders that are caused by mutations of 4 STAT family genes. Homozygous or compound heterozygous mutations of STAT1 lead to complete or partial forms of STAT1 deficiency that are associated with susceptibility to intracellular pathogens and herpetic infections. Read More

    Skin permeation of econazole nitrate formulated in an enhanced hydrophilic multiple emulsion.
    Mycoses 2017 Mar 20;60(3):166-177. Epub 2016 Oct 20.
    Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
    Local delivery of imidazolic antifungals is limited by its extreme lipophilicity. Multiple emulsions (ME) are a potential vehicle to enhance the delivery of econazole nitrate (ECN), an antifungal targeted to deep-seated epidermal yeast infections. An 1% ECN hydrophilic ME was compared with a commercial formulation in terms of rheology, droplet size and in vitro antifungal activity against Candida species. Read More

    Candida Esophagitis Associated With Mycophenolate Mofetil Treatment of Atopic Dermatitis.
    J Drugs Dermatol 2016 Oct;15(10):1267-1269
    Objective: To describe a case in which a patient developed Candida esophagitis (CE) after treatment of atopic dermatitis (AD) with mycophenolate mofetil (MMF) for 22 months.

    Case Summary: A 59-year-old Caucasian female with long-standing history of AD successfully treated with MMF presented to the dermatology clinic for follow-up appointment with 3 months' history of projectile vomiting, choking, and trouble swallowing. Patient underwent esophagogastroduodenoscopy (EGD) that demonstrated whitish plaques in esophagus consistent with CE, which was confirmed by biopsy and cytology. Read More

    Microdilution in vitro Antifungal Susceptibility Patterns of Candida Species, From Mild Cutaneous to Bloodstream Infections.
    Jundishapur J Microbiol 2016 Jul 5;9(7):e34151. Epub 2016 Jul 5.
    Department of Medical Mycology and Parasitology, Infection Diseases Research Center with Focus on Nosocomial Infection, Mazandaran University of Medical Sciences, Sari, IR Iran.
    Background: Candida species, as opportunistic organisms, can cause various clinical manifestations, ranging from mild cutaneous infections to systemic candidiasis in otherwise healthy individuals. Remarkably, the incidence and mortality rates of candidemia have significantly increased worldwide, even after advances in medical interventions and the development of novel antifungal drugs.

    Objectives: Given the possible resistance to antifungal agents, susceptibility testing can be useful in defining the activity spectrum of antifungals and determining the appropriate treatment regime. Read More

    Cutaneous problems in elderly diabetics: A population-based comparative cross-sectional survey.
    Indian J Dermatol Venereol Leprol 2017 Mar-Apr;83(2):205-211
    Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India.
    Background: There are few population-based studies on prevalence of cutaneous problems in diabetes mellitus.

    Aims: To identify skin problems associated with diabetes mellitus among elderly persons in a village in Kerala.

    Methods: In this population-based cross-sectional survey, we compared the prevalence of skin problems among 287 elderly diabetics (aged 65 years or more) with 275 randomly selected elderly persons without diabetes mellitus. Read More

    Immune reconstitution inflammatory syndrome associated with dermatophytoses in two HIV-1 positive patients in rural Tanzania: a case report.
    BMC Infect Dis 2016 09 20;16:495. Epub 2016 Sep 20.
    Chronic Diseases Clinic of Ifakara, Ifakara Health Institute, P. O Box 53, Ifakara, Tanzania.
    Background: Immune reconstitution inflammatory syndrome associated with dermatophytoses (tinea-IRIS) may cause considerable morbidity. Yet, it has been scarcely reported and is rarely considered in the differential diagnosis of HIV associated cutaneous lesions in Africa. If identified, it responds well to antifungals combined with steroids. Read More

    Primary deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man: the first case report and literature review.
    Mycoses 2016 Sep 7. Epub 2016 Sep 7.
    Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
    Superficial candida infections of the skin are common, but deep cutaneous candidiasis, including secondary dissemination to the skin from systemic candidiasis, candidaemia or primary invasion due to skin defects such as trauma, is rare. These patients are usually immunosuppressed, but immunocompetent hosts can be affected as well. Candida albicans is the most common pathogen. Read More

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