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Sci Rep 2018 Nov 20;8(1):17123. Epub 2018 Nov 20.

Research Unit on Oral Microbiology and Immunology and Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.

Dendritic cells (DCs) abundantly express diverse receptors to recognize mannans in the outer surface of Candida cell wall, and these interactions dictate the host immune responses that determine disease outcomes. C. krusei prevalence in candidiasis worldwide has increased since this pathogen has developed multidrug resistance. Read More

Curr Med Mycol 2018 Jun;4(2):27-31

Department of Prosthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Purpose: -associated denture stomatitis is one of the most common forms of oral candidiasis among denture wearers. Regarding this, the aim of the present study was to evaluate the antifungal effects of home-generated ozonated water on the adhesion of the C. attached to the surface of the denture base acrylic resins. Read More

Iran J Public Health 2018 Sep;47(9):1406-1412

Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Intertrigo is an erythematous inflammatory condition with multiple etiologies including fungi and bacteria. Intertrigo manifests in different clinical forms with various complaints. This study was conducted to evaluate the causative agents of intertriginous infections with emphasize on clinical presentations. Read More

JCI Insight 2018 Sep 6;3(17). Epub 2018 Sep 6.

Oral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, Maryland, USA.

Studies in patients with genetic defects can provide unique insights regarding the role of specific genes and pathways in humans. Patients with defects in the Th17/IL-17 axis, such as patients harboring loss-of-function STAT3 mutations (autosomal-dominant hyper IgE syndrome; AD-HIES) present with recurrent oral fungal infections. Our studies aimed to comprehensively evaluate consequences of STAT3 deficiency on the oral commensal microbiome. Read More

J Cosmet Dermatol 2018 Aug 31. Epub 2018 Aug 31.

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Mangalore, Karnataka, India.

Background: Dual-release mechanism of ethosomal gels (ie, ethosomes and gel) makes them as versatile drug delivery systems for topical applications. Clove oil is obtained from the clove buds exhibited broad antifungal and antibacterial activity. Cutaneous candidiasis is the infection caused by Candida albicans or other Candida species. Read More

J Fungi (Basel) 2018 Aug 20;4(3). Epub 2018 Aug 20.

Kings College London, London SE5 9RS, UK.

Treatment of superficial fungal infections has come a long way. This has, in part, been through the development and evaluation of new drugs. However, utilising new strategies, such as identifying variation between different species in responsiveness, e. Read More

Pharm Nanotechnol 2018 ;6(3):171-179

I.K. Gujral Punjab Technical University, Jalandhar, Punjab 144601, India.

Background: Transdermal drug delivery is an attractive approach for both local and systemic therapeutics of various diseases. Transdermal drug delivery systems show various advantages like reduction of local irritation, prevention of first-pass hepatic metabolism, and bioavailability enhancement of bioactive molecules over conventional drug delivery systems.

Objective: The main objective of the present research work was to develop and characterize (in-vitro and ex-vivo) econazole nitrate loaded transethosomes and their comparison with marketed cream of econazole nitrate [Ecoderm, Brown and Burk Pharmaceutical (Pvt. Read More

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418781368

3 Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University, Rome, Italy.

Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over 20 species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection. Read More

Nanomedicine (Lond) 2018 05 6;13(10):1139-1155. Epub 2018 Jun 6.

Department of Lipids & Liposomes, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.

Aim: Ebselen (Eb) is an example of a repurposed drug with poor aqueous solubility which requires sophisticated delivery system such as nanoencapsulation in nanocapsules for topical application.

Materials & Methods: Eb-nanocapsules were examined for morphology, activity against Candida spp., cytotoxicity and skin permeation. Read More

Orv Hetil 2018 Jun;159(23):937-947

Bőr-, Nemikórtani és Bőronkológiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

Primary immunodeficiency diseases (PIDs) are inherited, genetic disorders. The majority of PIDs are diagnosed in infancy or early childhood, but manifestation in adulthood may also occur. Frequent, recurrent and prolonged infections, which respond poorly to treatment may be heralding signs. Read More

Nat Rev Dis Primers 2018 May 11;4:18026. Epub 2018 May 11.

Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Read More

Am J Dermatopathol 2018 Oct;40(10):e138-e141

Dermatology Program, Harvard Medical School, Boston Children's Hospital, Boston, MA.

Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis that typically results from mutations of the GJB2 gene or, less commonly, the GJB6 gene. Patients with KID syndrome are at higher risk of malignancy and infections. Here, we present 2 patients with KID syndrome who developed verrucous plaques. Read More

J Glob Antimicrob Resist 2018 Sep 30;14:287-293. Epub 2018 Apr 30.

Department of Microbiology, Institute of Biological Sciences, University Federal of Minas Gerais, Av. Antônio Carlos 6627, P.O. Box 486, 31270-901 Belo Horizonte, MG, Brazil. Electronic address:

Objectives: Candida albicans is a commensal organism and opportunistic pathogen associated both with superficial (mucosal and cutaneous) and systemic infections. Extensive use of antifungal agents has led to reduced susceptibility to the few existing drugs, which has encouraged the search for novel antifungal agents. Therefore, the present study investigated the antifungal activity of 2,6-bis[(E)-(4-pyridyl)methylidene]cyclohexanone (PMC) against C. Read More

Curr Med Mycol 2017 Dec;3(4):21-25

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran.

Materials And Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. Read More

Am J Dermatopathol 2018 Nov;40(11):846-848

Department of Pathology, Hospital Clínico Universitario/INCLIVA, University of Valencia, Valencia, Spain.

Mucocutaneous candidiasis is a common infection affecting both immunocompetent and immunosuppressed individuals. Diversity in the clinical and histopathological presentation of mucocutaneous candidiasis is well known. However, the occurrence of cutaneous verrucous lesions and giant yeast-like structures has been rarely reported. Read More

Microb Pathog 2018 May 31;118:330-335. Epub 2018 Mar 31.

Laboratory of Medical Mycology, State University of Maringá, Brazil. Electronic address:

We isolated and identified yeasts from burn wounds and evaluated the ability of Candida parapsilosis isolates from burn wounds to penetrate an acellular dermal matrix (ADM). A prospective study was conducted with patients from the burn treatment center of North Paraná University Hospital in Londrina, Brazil from February 2015 to January 2016. Yeast cultures were obtained from the tissue of burn wounds that had been debrided and cleansed with 2% chlorhexidine. Read More

Curr Drug Deliv 2018 ;15(6):860-866

Department of Textile Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.

Background: Eugenol, as the major phenolic component of clove essential oil due to its desired properties in medical field, was loaded into polyacrylonitrile (PAN) nanofibers with various percentages.

Objective: Our main purpose in this study was to determine the in vitro antifungal activity of eugenol loaded on PAN nanofibers against Candida albicans as the most common causative agent for candidiasis.

Method: Also, the surface morphology and the mechanical properties of nanofibers were studied by scanning electron microscope (SEM) and a tensile tester, respectively. Read More

Mil Med 2018 Feb 13. Epub 2018 Feb 13.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand.

Background: Superficial fungal foot infection is one of the most important dermatological diseases currently affecting military personnel. Many Thai naval rating cadets are found to suffer from superficial fungal foot infections and their sequels.

Objective: To investigate prevalence, potent risk factors, responding pathogens and clinical correlation of superficial fungal foot infection in Thai naval rating cadets training in Naval rating school, Sattahip, Thailand. Read More

J Fungi (Basel) 2018 Feb 6;4(1). Epub 2018 Feb 6.

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus . infections are among the most common human mycoses. species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. Read More

J Fungi (Basel) 2018 Jan 18;4(1). Epub 2018 Jan 18.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M23 9LT, UK.

Objective: To estimate the burden of fungal infections in Jordan for the first time.

Material And Methods: Population data was from UN 2011 statistics and TB cases from WHO in 2012. Fewer than 100 patients with HIV were recorded in Jordan in 2013. Read More

Curr Med Mycol 2017 Jun;3(2):1-6

Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.

Background And Purpose: is the most common cause of candidal infections. Various studies have shown drug resistance among isolates; thus, it is necessary to discover replacement treatments for infections. In this study, we aimed to compare the effects of different essential oils against azoles-resistant and azoles-susceptible isolates. Read More

Curr Med Mycol 2017 Mar;3(1):13-19

Department of Microbiology, Yasooj Branch, Islamic Azad University, Yasooj, Iran.

Background And Purpose: The frequency of opportunistic fungal infections in immunocompromised patientsespecially by species has sharply increased in the last few decades. The objective of this study was to analyse the ergosterol content and gene expression profiling of clinical isolates of fluconazole-resistant

Materials And Methods: Sixty clinical samples were identified and collected from immunocompromised patients, namely recurrent oral, vaginal, and cutaneous candidiasis, during 2015-16. Antifungal susceptibility testing of fluconazole against clinical species was performed according to Clinical and Laboratory Standards Institute guidelines. Read More

Plast Reconstr Surg 2018 01;141(1):23-30

Naples, Italy From the Department of Plastic, Reconstructive and Aesthetic Surgery, the Department of Experimental Medicine, Section of Virology and Microbiology, Università della Campania Luigi Vanvitelli; the Unit of Plastic, Reconstructive and Aesthetic Surgery, Università Federico II; and the Department of Public Health.

Background: Capsular contracture around breast implants is a severe and unpredictable complication experienced by up to 50 percent of patients after breast augmentation and reconstruction, and represents a major cause leading to reoperation. Several lines of evidence point to the involvement of subclinical infections and of bacterial biofilm formation.

Methods: To reduce the incidence of capsular contracture following mammaplasty, the authors studied the correlation between contamination by exogenous and endogenous bacterial flora and the capacity to develop bacterial biofilm in mammary implants. Read More

Acta Dermatovenerol Croat 2017 Oct;25(3):248-250

Prof. Romana Čeović, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine, University of Zagreb, 10000 Zagreb, Šalata 4, Croatia;

Dear Editor, the association between lymphomas and autoimmune manifestations, as well as the prevalence of the cases of coexistent lymphomas and autoimmune conditions, has not been completely established (1-3). Since cutaneous T-cell lymphoma (CTCL) cases are rare, any hypothesis can only be based on case reports or small case series. We present the case of a male patient with folliculotropic mycosis fungoides (FMF) and synchronous autoimmune hepatitis (AIH) with extremely high levels of cancer antigen 19-9 (CA 19-9). Read More

Lasers Med Sci 2018 Jul 14;33(5):941-948. Epub 2017 Dec 14.

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania "Luigi Vanvitelli", Naples, Italy.

Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal side effects. Read More

Open Forum Infect Dis 2017 22;4(4):ofx202. Epub 2017 Sep 22.

Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Immunology, National Institutes of Health, Bethesda, Maryland.

Heterozygous gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 GOF patients with severe invasive or cutaneous fungal infections. Read More

J Mycol Med 2018 Jun 29;28(2):374-378. Epub 2017 Nov 29.

Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Golestan BLV, Ahvaz, Iran. Electronic address:

Objective: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials. Read More

Transl Pediatr 2017 Oct;6(4):300-312

The Ohio State University College of Medicine, Columbus, OH, USA.

The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

Mycopathologia 2018 Apr 22;183(2):417-421. Epub 2017 Nov 22.

Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou, 310014, Zhejiang, China.

The incidence of candidiasis due to non-albicans Candida species (especially Candida glabrata) has significantly increased in recent decades. Candida glabrata often invades immunocompromised hosts and causes systemic or mucosal infections, whereas cutaneous infections are rarely reported. We present a rare case of cutaneous infection caused by C. Read More

J Cytol 2017 Oct-Dec;34(4):179-182

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections.

Materials And Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). Read More

J Clin Lab Anal 2018 May 27;32(4):e22343. Epub 2017 Oct 27.

School of Life and Environmental Sciences, Faculty of Science Engineering and Built Environment, Deakin University, Burwood, Australia.

Background: Among the fungal pathogens, Candida species are the most common cause of urinary tract infection (UTI). Some predisposing factors such as diabetes mellitus, urinary retention, urinary stasis, renal transplantation, and hospitalization can increase the risk of candiduria. The aim of this cross-sectional study was to evaluate candiduria among type 2 diabetic patients and identification of the Candida isolates. Read More

Toxicol Pathol 2017 12 20;45(8):1032-1034. Epub 2017 Sep 20.

3 Toxicologic Pathology, Sackler School of Medicine, Tel Aviv University, Timrat, Israel.

The Göttingen minipig is often used in preclinical toxicity studies. Therefore, knowledge of spontaneously occurring pathologies is important to differentiate them from test drug-related effects. We report on a Göttingen minipig, which developed exudating widespread dermatitis during a preclinical toxicity study with a subcutaneously injected drug. Read More

Clin Microbiol Infect 2018 Mar 25;24(3):246-250. Epub 2017 Aug 25.

University Hospital, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

Background: Neutropenic patients developing acute disseminated candidiasis may present with skin lesions.

Aims: To evaluate the epidemiology of acute disseminated candidiasis with skin lesions in neutropenic patients, taking into consideration changes caused by different prophylactic strategies.

Sources: A systematic review of English-language articles found via PubMed (1963-2016) was performed. Read More

Am J Dermatopathol 2017 Aug;39(8):629

*Department of Medicine, Southern California Permanente Medical Group, Fontana Medical Center, Fontana, CA; †Department of Pathology, Southern California Permanente Medical Group, Sunset Medical Center, Los Angeles, CA; and ‡Internal Medicine Residency Program, State University New York, Downstate, Brooklyn, NY.

Curr Med Mycol 2016 Sep;2(3):1-4

Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Background And Purpose: Candidiasis is a widespread fungal infection caused by different species. Rapid identification of species in clinical laboratory is becoming increasingly important since the identification and discrimination of ethological agents for early treatment. We aimed at molecular identification of commonly species isolated from clinical samples by using both PCR-RFLP assay and amplification of hwp1 gene. Read More

Eur Rev Med Pharmacol Sci 2017 06;21(11):2749-2756

Infectious Diseases Unit Teaching Hospital S. Orsola-Malpighi, Alma Mater Studiorum University of Bologna, Bologna, Italy.

The resistance of microorganisms to antimicrobial drugs is a major issue for public health, with important consequences in terms of morbidity, mortality and resource use. The phenomenon is so serious that in some areas of the world resistant strains to all available drugs have been selected. Many conditions may result in the development of resistance: they include the indiscriminate or inappropriate (e. Read More

J Med Microbiol 2017 Jun 13;66(6):808-815. Epub 2017 Jun 13.

1​Department of Pathological Sciences, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380 - 86057-970, Londrina, PR, Brazil.

Purpose: Diabetic patients seem to be predisposed to cutaneous candidiasis. In this study, we evaluated the interference of diabetic conditions in alloxan-induced diabetic mice in relation to the development of C. albicans infection, density of M1 and M2 macrophages, distribution of collagen type I and III and anti-inflamamatory cytokines involved in tissue repair. Read More

Indian Dermatol Online J 2017 May-Jun;8(3):192-194

Department of Dermatology, National University Health System, Singapore.

The species are yeast-like opportunistic pathogens in immunocompromised patients. infections have been reported in pediatric bone marrow transplant (BMT) patients. However, its incidence is low in the adult literature. Read More

J Cosmet Laser Ther 2017 Oct 11;19(6):360-363. Epub 2017 May 11.

a Kasturba Medical College (KMC), Manipal University , Manipal , India.

Numerous skin lesions have been commonly observed in individuals with diabetes mellitus. The common skin manifestations of diabetes mellitus are erythrasma, xanthomatosis, xanthelasma, phycomycetes and cutaneous infections like furuncolosis, candidiasis, carbuncle, dermatophytosis, etc. Diabetic dermopathy is the most common skin lesion found in patients with diabetes. Read More

Saudi J Biol Sci 2017 May 2;24(4):907-914. Epub 2016 Jan 2.

Department of Pathobiology, Faculty of Veterinary Specialized Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran.

Mobile phones communicate with base stations using 900 MHz microwaves. The current study was aimed to survey the effects of long-term 900 MHz microwave exposure of mice on experimentally induced cutaneous candidiasis. Forty inbred, male, BALB/c mice were randomly divided into four groups. Read More

J Dermatol 2017 Aug 22;44(8):e206-e207. Epub 2017 Apr 22.

Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Clin Pediatr (Phila) 2017 May;56(5_suppl):16S-22S

1 Johns Hopkins Children's Center, Baltimore, MD, USA.

Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Read More

Am J Hematol 2017 Oct 9;92(10):1111-1112. Epub 2017 May 9.

Infectious and Tropical Diseases Unit, IRCCS "San Matteo", Pavia, Italy.

J Dermatol 2017 Jul 22;44(7):760-766. Epub 2017 Feb 22.

Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

The objective of the present randomized, double-blind trial was to evaluate the efficacy and safety of daily washing with miconazole nitrate-containing soap for candidiasis at diaper-covered sites in elderly subjects under long-term inpatient care. To confirm the onset and disappearance of candidiasis, we microscopically evaluated the existence of the pseudohyphae and/or blastoconidia of Candida spp. We enrolled 75 elderly patients who wore diapers all day in the hospital or nursing home. Read More

FP Essent 2017 Feb;453:26-32

University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.

Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

FP Essent 2017 Feb;453:11-17

University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.

Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

J Physiol Pharmacol 2016 Dec;67(6):851-858

Institute of Molecular and Cell Biology, Miguel Hernandez University, Alicante, Spain.

Econazole is an anti-mycotic agent widely used for the treatment of cutaneous fungal infections, and for the therapy of vaginal candidiasis. Topical application of this azole is generally safe, although some patients have complained of mild burning sensation/cutaneous irritation and itching, especially when administered intravaginally. The underlying mechanisms responsible of these adverse effects are poorly understood, though they suggest excitation of cutaneous nociceptor terminals. Read More

Eur J Clin Microbiol Infect Dis 2017 Jun 4;36(6):949-956. Epub 2017 Feb 4.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

The true burden of fungal infection in Pakistan is unknown. High-risk populations for fungal infections [tuberculosis (TB), diabetes, chronic respiratory diseases, asthma, cancer, transplant and human immunodeficiency virus (HIV) infection] are numerous. Here, we estimate the burden of fungal infections to highlight their public health significance. Read More

Clin Infect Dis 2017 May;64(10):1387-1395

Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

Background: Congenital cutaneous candidiasis (CCC) is a challenging diagnosis due to various rash presentations. Inadequate early treatment is associated with high rates of dissemination and death. The effects of early diagnosis, dermatologic presentation, and antifungal treatment on outcomes are lacking. Read More

Pediatr Dermatol 2017 Mar 23;34(2):201-203. Epub 2017 Jan 23.

Department of Dermatology, Instituto Nacional de Salud del Niño, Sede Breña, Lima, Peru.

Keratitis ichthyosis deafness (KID) syndrome is a rare genodermatosis with a high risk of cutaneous malignancy and infections. Infections can induce pseudocarcinomatous epidermal hyperplasia, leading to erroneous diagnosis of squamous cell carcinoma. We present a pediatric case of KID syndrome with vegetating plantar and acral candidiasis and highlight the importance of correct biopsy technique and clinicopathologic correlation in appropriate management. Read More