2,059 results match your criteria Candidiasis Cutaneous

Molecular targets for antifungals in amino acid and protein biosynthetic pathways.

Amino Acids 2021 Jun 3. Epub 2021 Jun 3.

Department of Pharmaceutical Technology and Biochemistry and BioTechMed Center, Gdańsk University of Technology, Gdańsk, Poland.

Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. Read More

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The Role of IL-17-Producing Cells in Cutaneous Fungal Infections.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Dermatology, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.

The skin is the outermost layer of the body and is exposed to many environmental stimuli, which cause various inflammatory immune responses in the skin. Among them, fungi are common microorganisms that colonize the skin and cause cutaneous fungal diseases such as candidiasis and dermatophytosis. The skin exerts inflammatory responses to eliminate these fungi through the cooperation of skin-component immune cells. Read More

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Congenital cutaneous candidiasis in one infant among a twin sibling pair.

Arch Dis Child Fetal Neonatal Ed 2021 May 27. Epub 2021 May 27.

Department of Pediatrics, Dokkyo Medical University, Shimotsuga-gun, Tochigi, Japan.

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Silver chitosan nanocomposites as a potential treatment for superficial candidiasis.

Med Mycol 2021 May 24. Epub 2021 May 24.

Laboratório de Glicobiología de Eucariotos (LaGE), Depto. Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, Brazil.

Silver compounds are widely known for their antimicrobial activity, but can exert toxic effects to the host. Among the strategies to reduce its toxicity, incorporation into biopolymers has shown promising results. We investigated the green syntheses of silver nanoparticles (AgNPs) and their functionalization in a chitosan matrix ([email protected]) as a potential treatment against Candida spp. Read More

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Prevalence of superficial-cutaneous fungal infections in Shiraz, Iran: A five-year retrospective study (2015-2019).

J Clin Lab Anal 2021 May 24:e23850. Epub 2021 May 24.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Superficial and cutaneous fungal infections are common in tropical areas. The aim of this study was to provide a basic database of superficial and cutaneous mycoses and the most common etiological agents among patients.

Methods: Between 2015 and 2019, a total of 1807 patients suspected of superficial and cutaneous mycosis referring to the mycology laboratory of Shiraz medical school, Fars, Iran were evaluated. Read More

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Cutaneous candidiasis caused by .

Pan Afr Med J 2021 16;38:178. Epub 2021 Feb 16.

Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Candidiasis is an acute or subacute fungal infection caused by fungi that belongs to candida genus, with Candida albicansbeing the most frequent causative agent. Candida kefyr is a rare cause of candidiasis which has been reported in systemic candidiasis and deep infections. However, to date, it has never been reported as a cause in dermatophytosis. Read More

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Non-specific oral and cutaneous manifestations of Coronavirus Disease 2019 in children.

Med Oral Patol Oral Cir Bucal 2021 Mar 27. Epub 2021 Mar 27.

Dental Clinic p.le Spedali Civili n.1 25133 Brescia, Italy

Background: Coronavirus Disease 2019 (COVID-19) seems to affect children only marginally, as a result, there is less knowledge of its manifestations in childhood. The purpose of this retrospective cross-sectional study was to investigate the oral and cutaneous manifestations in children affected by COVID-19.

Material And Methods: All the medical records of children with COVID-19 admitted to the Pediatric Clinic- ASST Spedali Civili of Brescia from March to April 2020 were reviewed. Read More

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Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis.

Microb Pathog 2021 May 16;154:104802. Epub 2021 Mar 16.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract diseases. This infection affects 75% of women on at least one occasion over a lifetime. The present systematic review and meta-analysis is the first to determine the prevalence of vulvovaginal candidiasis in Iranian women. Read More

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Analysis of Candida auris candidemia cases in an Intensive Care Unit of a tertiary hospital.

Rev Esp Anestesiol Reanim (Engl Ed) 2021 Feb 23. Epub 2021 Feb 23.

Servicio de Anestesiología, Reanimación y Tratamiento del Dolor, Hospital General Universitario de Valencia, Valencia, España.

Candida auris is a multi-resistant emerging fungus.

Objectives: To analyze the relationship between colonization by C.auris and the appearance of invasive candidiasis. Read More

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February 2021

[Disseminated infection caused by the bacillus Calmette-Guérin vaccine and SARS-CoV-2 coinfection in a patient with IL-12 receptor β1 subunit deficiency].

Rev Alerg Mex 2020 Oct-Dec;67(4):401-407

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades, Ciudad de México, México.

Background: Inborn errors of immunity manifest with a greater susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, or malignancies. One of these is the mendelian susceptibility to mycobacterial disease. The most frequent etiology is the complete autosomal recessive deficiency of the β1 subunit of the interleukin 12 receptor. Read More

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Interplay between Humoral and CLA T Cell Response against in Psoriasis.

Int J Mol Sci 2021 Feb 3;22(4). Epub 2021 Feb 3.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.

(CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA cutaneous lymphocyte antigen (CLA) T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, = 52), and also healthy individuals ( = 17). Read More

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February 2021

Congenital Cutaneous Candidiasis With Systemic Dissemination in a Preterm Infant.

Pediatr Infect Dis J 2021 Jun;40(6):e230-e233

Head of the Department of Neoantology, Hospital Clínico San Carlos/Universidad Complutense de Madrid. Madrid, Spain.

Congenital cutaneous candidiasis is an infrequent invasive fungal infection that usually appears in the first days of life. Extremely low birth weight infants are the most frequently affected. Classic presentation includes diffuse extensive erythematous rash with papules, plaques, pustules and vesicles, which later undergoes desquamation. Read More

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Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile.

J Mycol Med 2021 Mar 21;31(1):101086. Epub 2020 Nov 21.

Manchester Fungal Infection Group, faculty of medicine, biology and health, university of Manchester and Manchester academic health science centre, Manchester, UK.

Due to limited access to more powerful diagnostic tools, there are few data on the burden of fungal infections in Côte d'Ivoire, despite a high HIV and TB burden and many cutaneous diseases. Here we estimate the burden of serious fungal infections in this sub-Saharan country with a health profiling description. National demographics were used and PubMed searches to retrieve all published articles on fungal infections in Côte d'Ivoire and other bordering countries in West Africa. Read More

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NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-Like Disease.

J Invest Dermatol 2021 Jun 11;141(6):1404-1415. Epub 2020 Nov 11.

Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA. Electronic address:

Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy show diverse endocrine and nonendocrine manifestations initiated by self-reactive T cells because of AIRE mutation-induced defective central tolerance. A large number of American patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy suffer from early-onset cutaneous inflammatory lesions accompanied by an infiltration of T cells and myeloid cells. The role of myeloid cells in this setting remains to be fully investigated. Read More

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Oleic Acid Vesicles as a new Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar rats.

Recent Pat Antiinfect Drug Discov 2020 11 10. Epub 2020 Nov 10.

Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, India

Background: Cutaneous candidiasis is a deep-seated skin fungal infection that is most commonly observed in immunocompromised patients. This fungal infection is conventionally treated with various formulations like gels and creams which are having different side effects and least therapeutic efficacy. Hence, it becomes necessary to develop a novel carrier system for the treatment of this deep-seated skin fungal infection. Read More

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November 2020

Exploiting solid lipid nanoparticles and nanostructured lipid carriers for drug delivery against cutaneous fungal infections.

Crit Rev Microbiol 2021 Feb 6;47(1):79-90. Epub 2020 Nov 6.

School of Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.

Several types of cutaneous fungal infections can affect the population worldwide, such as dermatophytosis, cutaneous candidiasis, onychomycosis, and sporotrichosis. However, oral treatments have pronounced adverse effects, making the topical route an alternative to avoid this disadvantage. On the other hand, currently available pharmaceutical forms designed for topical application, such as gels and creams, do not demonstrate effective retention of biomolecules in the upper layers of the skin. Read More

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February 2021

Infections in Patients with Chronic Granulomatous Disease Treated with Tumor Necrosis Factor Alpha Blockers for Inflammatory Complications.

J Clin Immunol 2021 Jan 4;41(1):185-193. Epub 2020 Nov 4.

Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.

Purpose: Management of inflammatory complications of chronic granulomatous disease (CGD) is challenging. The aim of this study was to assess safety, with a focus on infections, and effectiveness of tumor necrosis factor alpha (TNF-α) blockers in CGD patients.

Methods: A retrospective, single-center cohort study of CGD patients treated by anti-TNF-α agents at Necker-Enfants Malades University Hospital (Paris, France) and registered at the French National Reference Center for Primary Immunodeficiencies (CEREDIH). Read More

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January 2021

Safety and effectiveness of secukinumab in psoriasis vulgaris and psoriatic arthritis: Real-world evidence in Japan.

J Dermatol 2021 Feb 25;48(2):175-183. Epub 2020 Oct 25.

Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.

Secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, has been available for the treatment of moderate to severe psoriasis and psoriatic arthritis since February 2015 in Japan. Because there was a time gap after the previous approval of biologics for psoriatic disease indication, it was suggested that patients to be treated with secukinumab at its launch might have refractory disease symptoms. In order to assess the safety and effectiveness of secukinumab in those patients, a 52-week, open-label, multicenter, observational cohort study was conducted. Read More

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February 2021

The pathogenic T387A missense mutation in the gene encoding signal transducer and activator of transcription 1 exhibits a differential gene expression profile.

Mol Immunol 2020 12 20;128:79-88. Epub 2020 Oct 20.

Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Göttingen, Germany; German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany. Electronic address:

Heterozygous gain-of-function (GOF) mutations in the interferon-driven transcription factor STAT1 (signal transducer and activator of transcription 1) cause chronic mucocutaneous candidiasis (CMC). In this study, we characterized the molecular basis of a CMC-associated missense mutation by introducing a threonine-to-alanine exchange in the STAT1 DNA-binding domain at position 387. This substitution had previously been described in a CMC patient with suppurative eyelid infection and cutaneous abscesses, which are both unusual symptoms in this immunodeficiency. Read More

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December 2020

Study of mucocutaneous manifestations of HIV and its relation to total lymphocyte count.

Indian J Sex Transm Dis AIDS 2020 Jan-Jun;41(1):47-52. Epub 2018 Apr 11.

Department of Dermatology, JSS Hospital, Mysore, Karnataka, India.

Introduction: HIV is associated with various mucocutaneous manifestations which may be the first pointers toward HIV and can also be prognostic markers for disease progression. This study was done to note the different mucocutaneous lesions present in HIV and their relation to total lymphocyte count (TLC).

Methodology: Three hundred and seventy-nine HIV patients attending the Department of Dermatology, Venereology, and Leprosy were included in the study. Read More

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Antifungal Photodynamic Activity of Hexyl-Aminolevulinate Ethosomes Against Biofilm.

Front Microbiol 2020 11;11:2052. Epub 2020 Sep 11.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Biofilm formation is responsible for the development of chronic and recurrent infections. The generation of biofilms is commonly accompanied by high resistance to conventional antifungal drugs, which can increase up to 1,000-fold. Fortunately, antimicrobial photodynamic therapy (aPDT) has shown excellent potential to treat biofilm infections. Read More

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September 2020

Correction to: Preparation and Characterization of Nanostructured Lipid Carriers for Improved Topical Drug Delivery: Evaluation in Cutaneous Leishmaniasis and Vaginal Candidiasis Animal Models.

AAPS PharmSciTech 2020 Oct 8;21(7):275. Epub 2020 Oct 8.

Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

In the published manuscript, co-author Sarah Hendrickx name was misspelled and co-author Guy Caljon's last and first names were inadvertently switched. Read More

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October 2020

Utilization of an in vitro biofabricated 3D skin as a pathological model of cutaneous candidiasis.

New Microbiol 2020 Oct 4;43(4):171-179. Epub 2020 Sep 4.

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.

Candida albicans is an opportunistic fungal infectious agent that can cause cutaneous candidiasis in humans. Biofilms formation of C. albicans is thought to be the major cause of antifungal drug resistance. Read More

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October 2020

Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment.

Front Microbiol 2020 26;11:2053. Epub 2020 Aug 26.

Department of Cosmetic Science, Providence University, Taichung, Taiwan.

is the most common cause of fungal infection. The emergence of drug resistance leads to the need for novel antifungal agents. We aimed to design naphthofuranquinone analogs to treat drug-resistant for topical application on cutaneous candidiasis. Read More

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Diaper rashes can indicate systemic conditions other than diaper dermatitis.

BMC Dermatol 2020 09 21;20(1). Epub 2020 Sep 21.

Pediatric Department, Dermatology Division, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Background: Although the majority of rashes in the diaper area are caused by irritation from urine and feces, irritant diaper dermatitis; IDD, there are some less common but potentially serious cutaneous eruptions associated with systemic diseases that should not be discounted.

Methods: This prospective descriptive study aimed to explore variation in cutaneous disease in the diaper area. It was conducted as a prospective descriptive study between October 2016 and November 2019 in the pediatric department of a tertiary-level hospital. Read More

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September 2020

Comparison of antifungal and cytotoxicity activities of titanium dioxide and zinc oxide nanoparticles with amphotericin B against different Candida species: In vitro evaluation.

J Clin Lab Anal 2021 Jan 12;35(1):e23577. Epub 2020 Sep 12.

Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Background: Candida species are known to cause serious fungal infections that produce cutaneous, mucosal, and systemic infections. Nowadays, mortality and morbidity candidiasis in immunocompromised patients have increased. Nanotechnology is a new world-known technology and includes particles ranging from about 1 to 100 nanometers. Read More

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January 2021

CARD9 Deficiency in a Chinese Man with Cutaneous Mucormycosis, Recurrent Deep Dermatophytosis and a Review of the Literature.

Mycopathologia 2020 Dec 31;185(6):1041-1050. Epub 2020 Aug 31.

Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiangwangmiao Street, Nanjing, 210042, Jiangsu, China.

Deficiency of caspase recruitment domain-containing protein 9 (CARD9) is an autosomal recessive primary immunodeficiency disorder, which typically predisposes immunocompetent individuals to single fungal infections and multiple fungal infections are very rare. We study an otherwise healthy 48-year-old man, who had been admitted to our hospital diagnosed with deep dermatophytosis caused by Trichophyton rubrum for three times at 29, 33 and 48 years old, respectively. At the age of 39 years, he suffered from cutaneous mucormycosis due to Mucor irregularis. Read More

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December 2020

Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts.

Scientifica (Cairo) 2020 11;2020:7503756. Epub 2020 Aug 11.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations.

Objective: This study was planned to evaluate the frequency of cutaneous presentations in HIV-infected patients and their association with the count of CD4 cells. Read More

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Distribution, antifungal susceptibility pattern and intra-Candida albicans species complex prevalence of Candida africana: A systematic review and meta-analysis.

PLoS One 2020 20;15(8):e0237046. Epub 2020 Aug 20.

Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Candida africana is a pathogenic species within the Candida albicans species complex. Due to the limited knowledge concerning its prevalence and antifungal susceptibility profiles, a comprehensive study is overdue. Accordingly, we performed a search of the electronic databases for literature published in the English language between 1 January 2001 and 21 March 2020. Read More

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October 2020

A rare complication of diaper rash: Granuloma gluteale infantum.

Dermatol Ther 2020 11 11;33(6):e14019. Epub 2020 Aug 11.

Faculty of Medicine, Department of Dermatology, Selcuk University, Konya, Turkey.

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November 2020