Search Our Scientific Publications & Authors

Methods Mol Biol 2022 ;2517:269-285

Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.

Candida auris infections present a critical problem to the healthcare system in many parts of the world. This yeast clinically manifests as a disseminated candidiasis which can be life-threating for susceptible individuals, as well as cutaneous and wound infections. Moreover, C. Read More

AACN Adv Crit Care 2022 Jun;33(2):165-172

Holly Kirkland-Kyhn is Director of Wound Care, University of California, Davis Medical Center, Sacramento, California.

Critically ill patients are at high risk for organ failure, including that of the integumentary system. Nurses working in intensive care are adept at performing comprehensive assessments that include the skin. Although pressure injury is a well-known complication associated with critical illness, patients may also have debilitating and life-threatening dermatoses. Read More

Indian J Dermatol 2022 Jan-Feb;67(1):54-57

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Ectodermal dysplasias (EDs) affect structures derived from the ectoderm such as skin, its appendages, nail, and teeth. In this series, we describe four patients presenting with a clinical phenotype of dysplasia of one or more ectodermal structures who underwent next-generation sequencing for mutational analysis.

Case Series: The clinical phenotype of three patients was hypohidrotic ectodermal dysplasia (HED) and one patient was diagnosed with autoimmune polyglandular syndrome (APS) type 1. Read More

Int Immunol 2022 May 31. Epub 2022 May 31.

Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan.

IL-17 plays important roles in host defense against Candida albicans at barrier surfaces and during invasive infection. However, the role of IL-17 in host defense after colonization of the epidermis, a main site of C. albicans infection remains poorly understood. Read More

J Mycol Med 2022 May 10;32(3):101293. Epub 2022 May 10.

Adjunct Professor of Clinical Mycology and Supervised Internship at State University of Centro-Oeste (UNICENTRO-Paraná).

We probably describe the first report of esophageal rupture in a patient with autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED, OMIM # 240300), who had candida esophagitis as the main feature for decades. Strong evidence shows that this rupture may have been caused directly and indirectly by chronic candidiasis. In this way, we demonstrate how severe and harmful the persistent esophageal candidiasis can cause in the esophagus, especially in immunodeficient patients. Read More

Clin Case Rep 2022 May 12;10(5):e05773. Epub 2022 May 12.

Department of Neonatology Hospital Universitario Mayor Méderi-Universidad del Rosario Bogotá Colombia.

Congenital cutaneous candidiasis (CCC) is a rare and usually benign disorder that develops within the first week of life. It predominantly presents with diffuse maculopapular and papulopustular erythematous desquamating patches. We report a preterm neonate with respiratory distress syndrome and skin diffuse maculopapular lesions at birth. Read More

JAMA Dermatol 2022 May 11. Epub 2022 May 11.

Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.

Importance: Psoriasis is a chronic disease requiring long-term management; understanding the long-term safety profiles of psoriasis treatments, such as bimekizumab, is important.

Objective: To evaluate the 2-year safety profile of bimekizumab in patients with moderate to severe plaque psoriasis.

Design, Setting, And Participants: Safety data were pooled from a cohort of patients from 4 phase 2 randomized clinical trials (BE ABLE 1, BE ABLE 2, PS0016, and PS0018) and 4 phase 3 randomized clinical trials (BE VIVID, BE READY, BE SURE, and BE BRIGHT) to include 2 years of study treatment. Read More

Curr Med Mycol 2021 Sep;7(3):18-21

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Purpose: Resistance to antifungal drugs is increasing among isolates from patients with vulvovaginal candidiasis (VVC). Lack of correct diagnosis of causing VVC and the experimental use of antifungal drugs are the main causes of this resistance. This study aimed to determine the susceptibility of antifungal drugs against species isolated from VVC in Northeastern Iran. Read More

J Clin Immunol 2022 Apr 14. Epub 2022 Apr 14.

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Purpose: Although mast cells (MCs) modulate the activity of effector cells during Candida albicans infection, their role in the pathogenesis of candidiasis remains unclear. Candidalysin, a C. albicans-derived peptide toxin, is a crucial factor in fungal infections. Read More

Mycoses 2022 May 31;65(5):560-566. Epub 2022 Mar 31.

Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, Brazil.

Objectives: Dermatomycoses, fungal diseases that affect the superficial layers of skin, hair or nails, are a public health concern due to their high prevalence. In Brazil, dermatomycoses are not notifiable diseases, so only fragmented epidemiological studies have been reported in the national literature. To evaluate the epidemiological profile of dermatomycoses in preschoolers and school children in Sinop, Mato Grosso (MT), Brazil. Read More

Pathogens 2022 Feb 6;11(2). Epub 2022 Feb 6.

Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

is a commensal fungus that asymptomatically colonizes the skin and mucosa of 60% of healthy individuals. Breaches in the cutaneous and mucosal barriers trigger candidiasis that ranges from asymptomatic candidemia and mucosal infections to fulminant sepsis with 70% mortality rates. Fungi influence at least several diseases, in part by mechanisms such as the production of pro-carcinogenic agents, molecular mimicking, and triggering of the inflammation cascade. Read More

Pediatr Rheumatol Online J 2022 Feb 22;20(1):16. Epub 2022 Feb 22.

Madigan Army Medical Center Department of Pediatrics, Honolulu, HI, USA.

Background: Macrophage activation syndrome (MAS) is a severe and under-recognized complication of rheumatologic diseases. We describe a patient who presented with rapidly progressive, refractory MAS found to have anti-MDA5 antibody Juvenile Dermatomyositis (JDM) as her underlying rheumatologic diagnosis.

Case Presentation: We describe a 14-year-old female who at the time of admission had a history of daily fevers for 6 weeks and an unintentional sixteen-pound weight loss. Read More

BMC Microbiol 2022 02 4;22(1):45. Epub 2022 Feb 4.

Miller School of Medicine, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Wound Healing Research Laboratory Miami, University of Miami, Miami, 33136, FL, United States.

Candida albicans is a common cause of opportunistic mycoses worldwide and a major contributor in wound infections. The purpose of this study was to establish a fungal wound model and analyze the effects of a common antifungal agent against the proliferation of three C. albicans strains. Read More

Med Mycol Case Rep 2022 Mar 19;35:39-42. Epub 2022 Jan 19.

Istituto Veterinario di Novara, S.P.9 Granozzo con Monticello, 28060, Novara, Italy.

Cutaneous candidiasis is usually related to immunosuppressive diseases and/or therapies as predisposing factors. In humans, chronic mucocutaneous candidiasis (CMC) is observed with thymoma and thymectomy. In this case report we describe the clinical and pathological findings, laboratory analysis, treatment, and follow-up of a thymectomized dog with cutaneous and mucocutaneous generalized candidiasis. Read More

J Mycol Med 2022 May 30;32(2):101243. Epub 2021 Dec 30.

Intensive Care Haematology Department, University Hospital of Besançon, France.

Candida tropicalis is the Candida species that is mostly involved in case of acute disseminated candidiasis. We report here a case with whole body dissemination (pulmonary, cutaneous, muscular, hepatic, spinal and cerebral) highlighted by impressive imagery obtained by positron emission tomography scanner in a patient treated for T cell acute lymphocytic leukemia. Read More

Front Immunol 2021 20;12:760019. Epub 2021 Dec 20.

Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, Strasbourg, France.

Purpose: Heterozygous missense mutations leading to a gain of function (GOF) are the most frequent genetic cause of chronic mucocutaneous candidiasis (CMC). We describe the case of a patient presenting a new GOF mutation of with the clinical symptoms of CMC, recurrent pneumonia, and persistent central erythema with papulopustules with ocular involvement related to rosacea-like demodicosis.

Methods: Genetic analysis targeted next-generation sequencing (NGS; NGS panel DIPAI v. Read More

Am J Chin Med 2021 ;49(8):1871-1895

Department of Dermatology, No. 1 Hospital of China Medical University, 155N, Nanjing Street, Heping District, Shenyang, Liaoning 110000, P. R. China.

Shikonin is one of the primary active components extracted from the dried root of (), a traditional Chinese herbal medicine. Shikonin is known to not only exert anti-proliferative, anti-inflammatory, and anti-angiogenic activities, but also play a crucial role in triggering the production of reactive oxygen species, suppressing the release of exosomes, and inducing apoptosis. Increasing evidence suggests that shikonin has a protective effect against skin diseases, including psoriasis, melanoma, and hypertrophic scars. Read More

Cureus 2021 Nov 21;13(11):e19784. Epub 2021 Nov 21.

Internal Medicine, Unidade Local de Saúde do Alto Minho, Viana do Castelo, PRT.

Langerhans cell histiocytosis is a rare hematologic neoplasm with a myeloid origin, which can affect numerous organs, the skin being the second most frequently affected by this disease. In this report, a case of a 44-year-old female, who was intermittently followed due to a suspected persistent cutaneous candidiasis in which a skin biopsy revealed Langerhans cell histiocytosis with immunohistochemistry positive for CD1a and S100 protein, is described. The management of Langerhans cell histiocytosis is difficult because these disorders respond inconsistently to immunosuppressive and chemotherapeutic strategies. Read More

Lancet Reg Health Eur 2022 Feb 22;13:100266. Epub 2021 Nov 22.

Department of Internal Medicine and Radboudumc Center for Infectious diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Biologics directed against the T-helper (Th)-17 pathway have been approved for several inflammatory diseases. Interleukin (IL)-17 is involved in anti- host defense, and clinical trials suggested increased candidiasis incidence during IL-17 inhibitor therapy. We describe the worldwide epidemiology of candidiasis during Th17 inhibitor therapy, and immunological mechanisms involved in candidiasis susceptibility. Read More

Mycoses 2022 Mar 30;65(3):323-330. Epub 2021 Dec 30.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia - dr. Cipto Mangunkusumo National Central General Hospital, Central Jakarta, Jakarta, Indonesia.

Background: To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.

Objectives: To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population and its associated factors in Indonesia. Read More

J Obstet Gynaecol India 2021 Dec 9;71(6):577-582. Epub 2021 Nov 9.

Department of Community Medicine at TNMC, BYL Nair Charitable Hospital, Mumbai, India.

Fungal skin infections are on the rise in India, and pregnant women are not immune to them. They are one of the commonest causes of secondary pruritus in pregnancy and can worsen the quality of life. Cutaneous dermatophytic infections have seen a recent emergence as a public health problem in India with increasing incidence as well as failure to appropriately respond to treatment. Read More

Rev Esp Quimioter 2022 Feb 30;35(1):84-86. Epub 2021 Nov 30.

Celia Roig Martí, Servicio de Medicina Interna. Hospital General Universitario de Castellón. Castellón. Spain.

J Clin Immunol 2022 02 17;42(2):336-349. Epub 2021 Nov 17.

Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, MD, Bethesda, USA.

Background: CARD9 deficiency is an autosomal recessive primary immunodeficiency underlying increased susceptibility to fungal infection primarily presenting as invasive CNS Candida and/or cutaneous/invasive dermatophyte infections. More recently, a rare heterozygous dominant negative CARD9 variant c.1434 + 1G > C was reported to be protective from inflammatory bowel disease. Read More

Pharmaceuticals (Basel) 2021 Oct 12;14(10). Epub 2021 Oct 12.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain.

The higher molecular weight and low solubility of amphotericin B (AmB) hinders its topical administration. The aim of this study was to incorporate essential oil into an AmB topical gel (AmB + BGEO gel) in order to promote the diffusion of the drug through the skin in the treatment of cutaneous candidiasis. AmB + BGEO gel formulation was determined using a factorial experiment. Read More

Mikrobiyol Bul 2021 Oct;55(4):656-664

Ondokuz Mayıs University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.

Primary immunodeficiencies are disorders that cause clinical findings ranging from mild diseases to life-threatening diseases in a wide age range. Infections are the most common complications of primary immunodeficiencies. Caspase associated recruitment domain-9 (CARD9) is a protein that plays a role in fungal immune response. Read More

Int J Infect Dis 2021 12 29;113:109-112. Epub 2021 Sep 29.

Erasmus MC University Medical Center, Department of Medical Microbiology & Infectious Diseases, Rotterdam, the Netherlands.

Background: Leishmaniasis is a parasitic disease caused by different Leishmania species. L. infantum is found in the Mediterranean area. Read More

J Invest Dermatol 2022 03 22;142(3 Pt B):867-875. Epub 2021 Sep 22.

Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and how they are involved in cutaneous pathogenic responses. It will also discuss cutaneous dysbiosis and FOXP3 regulatory T cells in the context of inflammatory conditions linked to IL-17 responses in the skin. Specifically, it will review key literature on chronic mucocutaneous candidiasis and psoriasis. Read More

Curr Med Mycol 2021 Mar;7(1):1-5

Department of Basic Sciences, College of Dentistry, University of Kufa, Al-Najaf, Iraq.

Background And Purpose: Mineral nanoparticle synthesis via green chemistry is ‎considered a novel ‏procedure ‎that ‎has been introduced into some ‏‎‎industries and medical fields. This ‎paper aimed to focus on ‏synthesized gold ‎nanoparticles ‎‎‎‎(‎AuNPs‎) prepared via green chemistry and ‎their usage in the ‏treatment of cutaneous ‎candidiasis.‎‎. Read More

Rev Esp Anestesiol Reanim (Engl Ed) 2021 Oct 17;68(8):431-436. Epub 2021 Sep 17.

Servicio de Anestesiología, Reanimación y Tratamiento del Dolor, Hospital General Universitario de Valencia, Valencia, Spain.

Candida auris is a multi-resistant emerging fungus.

Objectives: To analyze the relationship between colonization by C. auris and the appearance of invasive candidiasis. Read More

Front Immunol 2021 5;12:682350. Epub 2021 Aug 5.

Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Chronic mucocutaneous candidiasis (CMC) is a disorder of recurrent or persistent chronic noninvasive symptomatic infections of the skin, nails and mucous membranes. This disorder is primarily caused by . Many factors, including primary immunodeficiencies, can make a host more susceptible to CMC. Read More