1,974 results match your criteria Candidiasis Cutaneous


Fatal necrotizing esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.

Autops Case Rep 2019 Apr-Jun;9(2):e2018070. Epub 2019 Mar 22.

Universidade de São Paulo (USP), Hospital Universitário, Internal Medicine Division. São Paulo, SP, Brazil.

Esophageal infection by spp. is a common opportunistic entity in immunocompromised hosts; however, systemic fungal dissemination due to perforation or transmural necrosis, also known as necrotizing esophagitis (NCE), is rare. We report the case of a 61-year-old male patient with diagnosed ankylosing spondylitis, severe arteriosclerosis, and vasculitis under immunosuppressive therapy who presented NCE with fungal and bacterial septicemia diagnosed at autopsy. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433139PMC
March 2019
3 Reads

Severe Cutaneous Candidiasis in a Liver Transplant Patient.

Int J Organ Transplant Med 2019 1;10(1):46-50. Epub 2019 Feb 1.

Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

infections are common diseases in immunocompromised patients. A 19-year-old boy with liver transplantation, necrotic skin lesion, jaundice, dyspnea, and ascites was admitted to Namazi Hospital, Shiraz, southern Iran. The mycological examination for the skin lesion was requested. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416996PMC
February 2019
4 Reads

The Skin as a Window into Primary Immune Deficiency Diseases: Atopic Dermatitis and Chronic Mucocutaneous Candidiasis.

J Allergy Clin Immunol Pract 2019 Mar;7(3):788-798

Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY.

Primary immune deficiency diseases characteristically present with recurrent, severe, or unusual infections. These infections may often involve the skin, with mucocutaneous candidal infections seen in a variety of different primary immune deficiencies. Primary immune deficiencies may also present with noninfectious cutaneous complications, of which eczema is the most common. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.11.026DOI Listing
March 2019
2 Reads

Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2/MyD88-dependent pathway.

Sci Rep 2018 Nov 20;8(1):17123. Epub 2018 Nov 20.

Research Unit on Oral Microbiology and Immunology and Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.

Dendritic cells (DCs) abundantly express diverse receptors to recognize mannans in the outer surface of Candida cell wall, and these interactions dictate the host immune responses that determine disease outcomes. C. krusei prevalence in candidiasis worldwide has increased since this pathogen has developed multidrug resistance. Read More

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http://dx.doi.org/10.1038/s41598-018-35101-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244250PMC
November 2018
1 Read

Kinetics of antifungal activity of home-generated ozonated water on .

Curr Med Mycol 2018 Jun;4(2):27-31

Department of Prosthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Purpose: -associated denture stomatitis is one of the most common forms of oral candidiasis among denture wearers. Regarding this, the aim of the present study was to evaluate the antifungal effects of home-generated ozonated water on the adhesion of the C. attached to the surface of the denture base acrylic resins. Read More

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http://dx.doi.org/10.18502/cmm.4.2.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181063PMC
June 2018
13 Reads

Investigation of Intertriginous Mycotic and Pseudomycotic (Erythrasma) Infections and Their Causative Agents with Emphasize on Clinical Presentations.

Iran J Public Health 2018 Sep;47(9):1406-1412

Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Intertrigo is an erythematous inflammatory condition with multiple etiologies including fungi and bacteria. Intertrigo manifests in different clinical forms with various complaints. This study was conducted to evaluate the causative agents of intertriginous infections with emphasize on clinical presentations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174041PMC
September 2018
21 Reads

Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis.

JCI Insight 2018 Sep 6;3(17). Epub 2018 Sep 6.

Oral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, Maryland, USA.

Studies in patients with genetic defects can provide unique insights regarding the role of specific genes and pathways in humans. Patients with defects in the Th17/IL-17 axis, such as patients harboring loss-of-function STAT3 mutations (autosomal-dominant hyper IgE syndrome; AD-HIES) present with recurrent oral fungal infections. Our studies aimed to comprehensively evaluate consequences of STAT3 deficiency on the oral commensal microbiome. Read More

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http://dx.doi.org/10.1172/jci.insight.122061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171814PMC
September 2018
5 Reads

Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis.

J Cosmet Dermatol 2018 Aug 31. Epub 2018 Aug 31.

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Mangalore, Karnataka, India.

Background: Dual-release mechanism of ethosomal gels (ie, ethosomes and gel) makes them as versatile drug delivery systems for topical applications. Clove oil is obtained from the clove buds exhibited broad antifungal and antibacterial activity. Cutaneous candidiasis is the infection caused by Candida albicans or other Candida species. Read More

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http://dx.doi.org/10.1111/jocd.12765DOI Listing
August 2018
11 Reads
1.000 Impact Factor

Therapy of Skin, Hair and Nail Fungal Infections.

Authors:
Roderick Hay

J Fungi (Basel) 2018 Aug 20;4(3). Epub 2018 Aug 20.

Kings College London, London SE5 9RS, UK.

Treatment of superficial fungal infections has come a long way. This has, in part, been through the development and evaluation of new drugs. However, utilising new strategies, such as identifying variation between different species in responsiveness, e. Read More

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http://dx.doi.org/10.3390/jof4030099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162762PMC
August 2018
4 Reads

Angioinvasive fungal infections impacting the skin: Background, epidemiology, and clinical presentation.

J Am Acad Dermatol 2019 Apr 10;80(4):869-880.e5. Epub 2018 Aug 10.

Department of Dermatology and Pathology, University of Iowa, Iowa City, Iowa. Electronic address:

Angioinvasive fungal infections cause significant morbidity and mortality because of their propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia, infarct, and necrosis. While occasionally seen in immunocompetent hosts, opportunistic fungi are emerging in immunosuppressed hosts, including patients with hematologic malignancy, AIDS, organ transplant, and poorly controlled diabetes mellitus. The widespread use of antifungal prophylaxis has led to an "arms race" of emerging fungal resistance patterns. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.059DOI Listing
April 2019
19 Reads

Transethosomes of Econazole Nitrate for Transdermal Delivery: Development, In-vitro Characterization, and Ex-vivo Assessment.

Pharm Nanotechnol 2018 ;6(3):171-179

I.K. Gujral Punjab Technical University, Jalandhar, Punjab 144601, India.

Background: Transdermal drug delivery is an attractive approach for both local and systemic therapeutics of various diseases. Transdermal drug delivery systems show various advantages like reduction of local irritation, prevention of first-pass hepatic metabolism, and bioavailability enhancement of bioactive molecules over conventional drug delivery systems.

Objective: The main objective of the present research work was to develop and characterize (in-vitro and ex-vivo) econazole nitrate loaded transethosomes and their comparison with marketed cream of econazole nitrate [Ecoderm, Brown and Burk Pharmaceutical (Pvt. Read More

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http://dx.doi.org/10.2174/2211738506666180813122102DOI Listing
January 2019
7 Reads

Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418781368

3 Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University, Rome, Italy.

Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over 20 species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection. Read More

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http://dx.doi.org/10.1177/2058738418781368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398342PMC
October 2018
5 Reads

Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity.

Nanomedicine (Lond) 2018 05 6;13(10):1139-1155. Epub 2018 Jun 6.

Department of Lipids & Liposomes, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.

Aim: Ebselen (Eb) is an example of a repurposed drug with poor aqueous solubility which requires sophisticated delivery system such as nanoencapsulation in nanocapsules for topical application.

Materials & Methods: Eb-nanocapsules were examined for morphology, activity against Candida spp., cytotoxicity and skin permeation. Read More

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http://dx.doi.org/10.2217/nnm-2017-0337DOI Listing
May 2018
2 Reads

[Cutaneous manifestations in primary immunodeficiency diseases].

Orv Hetil 2018 Jun;159(23):937-947

Bőr-, Nemikórtani és Bőronkológiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

Primary immunodeficiency diseases (PIDs) are inherited, genetic disorders. The majority of PIDs are diagnosed in infancy or early childhood, but manifestation in adulthood may also occur. Frequent, recurrent and prolonged infections, which respond poorly to treatment may be heralding signs. Read More

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http://dx.doi.org/10.1556/650.2018.30994DOI Listing
June 2018
8 Reads

Successful Sequential Treatment with Itraconazole and ALA-PDT for Cutaneous Granuloma by Candida albicans: A Case Report and Literature Review.

Mycopathologia 2018 Oct 16;183(5):829-834. Epub 2018 May 16.

Institute of Photomedicine, Shanghai Dermatology Hospital, Shanghai, China.

Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. Read More

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http://link.springer.com/10.1007/s11046-018-0267-4
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http://dx.doi.org/10.1007/s11046-018-0267-4DOI Listing
October 2018
4 Reads

Invasive candidiasis.

Nat Rev Dis Primers 2018 May 11;4:18026. Epub 2018 May 11.

Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Read More

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http://dx.doi.org/10.1038/nrdp.2018.26DOI Listing
May 2018
4 Reads

Two Cases of Chronic Candidiasis in Keratitis-Ichthyosis-Deafness Syndrome.

Am J Dermatopathol 2018 Oct;40(10):e138-e141

Dermatology Program, Harvard Medical School, Boston Children's Hospital, Boston, MA.

Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis that typically results from mutations of the GJB2 gene or, less commonly, the GJB6 gene. Patients with KID syndrome are at higher risk of malignancy and infections. Here, we present 2 patients with KID syndrome who developed verrucous plaques. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001178DOI Listing
October 2018

In vivo and in vitro activity of a bis-arylidenecyclo-alkanone against fluconazole-susceptible and -resistant isolates of Candida albicans.

J Glob Antimicrob Resist 2018 Sep 30;14:287-293. Epub 2018 Apr 30.

Department of Microbiology, Institute of Biological Sciences, University Federal of Minas Gerais, Av. Antônio Carlos 6627, P.O. Box 486, 31270-901 Belo Horizonte, MG, Brazil. Electronic address:

Objectives: Candida albicans is a commensal organism and opportunistic pathogen associated both with superficial (mucosal and cutaneous) and systemic infections. Extensive use of antifungal agents has led to reduced susceptibility to the few existing drugs, which has encouraged the search for novel antifungal agents. Therefore, the present study investigated the antifungal activity of 2,6-bis[(E)-(4-pyridyl)methylidene]cyclohexanone (PMC) against C. Read More

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http://dx.doi.org/10.1016/j.jgar.2018.04.012DOI Listing
September 2018
15 Reads

Identification of species isolated from vulvovaginitis using matrix assisted laser desorption ionization-time of flight mass spectrometry.

Curr Med Mycol 2017 Dec;3(4):21-25

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background And Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran.

Materials And Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. Read More

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http://dx.doi.org/10.29252/cmm.3.4.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917097PMC
December 2017
6 Reads

Verrucous Plaque With Unusually Large Candida Blastoconidia: A Unique Clinicopathological Presentation of Systemic Mucocutaneous Candidiasis.

Am J Dermatopathol 2018 Nov;40(11):846-848

Department of Pathology, Hospital Clínico Universitario/INCLIVA, University of Valencia, Valencia, Spain.

Mucocutaneous candidiasis is a common infection affecting both immunocompetent and immunosuppressed individuals. Diversity in the clinical and histopathological presentation of mucocutaneous candidiasis is well known. However, the occurrence of cutaneous verrucous lesions and giant yeast-like structures has been rarely reported. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001153DOI Listing
November 2018
38 Reads

Development of a contaminated ischemic porcine wound model and the evaluation of bromelain based enzymatic debridement.

Burns 2018 06 13;44(4):896-904. Epub 2018 Apr 13.

Mediwound Ltd., Yavneh, Israel; Department of Plastic and Reconstructive Surgery, Ben Gurion University, Beer-Sheba, Israel.

Objectives: There are no well accepted animal models of chronic wounds, limiting advances in understanding and treatment of chronic ulcers. We developed a porcine wound model which combines multiple factors involved in chronic wounds to create a contaminated necrotic eschar and evaluated the debriding efficacy of a novel bromelain based enzymatic debriding agent (EscharEx).

Methods: Contaminated ischemic wounds were created on the flanks of domestic pigs by 'sandwiching' the skin between 2 'O' rings (1 placed on the surface of the skin and the other underneath the skin) for 24h prior to dermatomal excision of the necrotic eschar and its contamination with Staphylococcus aureus and Candida albicans. Read More

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http://dx.doi.org/10.1016/j.burns.2017.07.022DOI Listing
June 2018
8 Reads

Candida parapsilosis isolates from burn wounds can penetrate an acellular dermal matrix.

Microb Pathog 2018 May 31;118:330-335. Epub 2018 Mar 31.

Laboratory of Medical Mycology, State University of Maringá, Brazil. Electronic address:

We isolated and identified yeasts from burn wounds and evaluated the ability of Candida parapsilosis isolates from burn wounds to penetrate an acellular dermal matrix (ADM). A prospective study was conducted with patients from the burn treatment center of North Paraná University Hospital in Londrina, Brazil from February 2015 to January 2016. Yeast cultures were obtained from the tissue of burn wounds that had been debrided and cleansed with 2% chlorhexidine. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.03.058DOI Listing
May 2018
4 Reads

Antifungal Activity of Eugenol Loaded Electrospun PAN Nanofiber Mats Against Candida Albicans.

Curr Drug Deliv 2018 ;15(6):860-866

Department of Textile Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.

Background: Eugenol, as the major phenolic component of clove essential oil due to its desired properties in medical field, was loaded into polyacrylonitrile (PAN) nanofibers with various percentages.

Objective: Our main purpose in this study was to determine the in vitro antifungal activity of eugenol loaded on PAN nanofibers against Candida albicans as the most common causative agent for candidiasis.

Method: Also, the surface morphology and the mechanical properties of nanofibers were studied by scanning electron microscope (SEM) and a tensile tester, respectively. Read More

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http://dx.doi.org/10.2174/1567201815666180226120436DOI Listing
December 2018
22 Reads

Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets.

Mil Med 2018 Feb 13. Epub 2018 Feb 13.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand.

Background: Superficial fungal foot infection is one of the most important dermatological diseases currently affecting military personnel. Many Thai naval rating cadets are found to suffer from superficial fungal foot infections and their sequels.

Objective: To investigate prevalence, potent risk factors, responding pathogens and clinical correlation of superficial fungal foot infection in Thai naval rating cadets training in Naval rating school, Sattahip, Thailand. Read More

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http://dx.doi.org/10.1093/milmed/usx187DOI Listing
February 2018
6 Reads

Experimental in Vivo Models of Candidiasis.

J Fungi (Basel) 2018 Feb 6;4(1). Epub 2018 Feb 6.

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus . infections are among the most common human mycoses. species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. Read More

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http://www.mdpi.com/2309-608X/4/1/21
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http://dx.doi.org/10.3390/jof4010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872324PMC
February 2018
8 Reads

Burden of Serious Fungal Infections in Jordan.

J Fungi (Basel) 2018 Jan 18;4(1). Epub 2018 Jan 18.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M23 9LT, UK.

Objective: To estimate the burden of fungal infections in Jordan for the first time.

Material And Methods: Population data was from UN 2011 statistics and TB cases from WHO in 2012. Fewer than 100 patients with HIV were recorded in Jordan in 2013. Read More

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http://dx.doi.org/10.3390/jof4010015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872318PMC
January 2018
7 Reads

antifungal activity of essential oils extracted from plants against fluconazole-susceptible and -resistant .

Curr Med Mycol 2017 Jun;3(2):1-6

Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.

Background And Purpose: is the most common cause of candidal infections. Various studies have shown drug resistance among isolates; thus, it is necessary to discover replacement treatments for infections. In this study, we aimed to compare the effects of different essential oils against azoles-resistant and azoles-susceptible isolates. Read More

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http://dx.doi.org/10.18869/acadpub.cmm.3.2.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763891PMC
June 2017
7 Reads

Quantitation of ergosterol content and gene expression profile of gene in fluconazole-resistant .

Curr Med Mycol 2017 Mar;3(1):13-19

Department of Microbiology, Yasooj Branch, Islamic Azad University, Yasooj, Iran.

Background And Purpose: The frequency of opportunistic fungal infections in immunocompromised patientsespecially by species has sharply increased in the last few decades. The objective of this study was to analyse the ergosterol content and gene expression profiling of clinical isolates of fluconazole-resistant

Materials And Methods: Sixty clinical samples were identified and collected from immunocompromised patients, namely recurrent oral, vaginal, and cutaneous candidiasis, during 2015-16. Antifungal susceptibility testing of fluconazole against clinical species was performed according to Clinical and Laboratory Standards Institute guidelines. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747584PMC
March 2017
2 Reads

Microbial Evaluation in Capsular Contracture of Breast Implants.

Plast Reconstr Surg 2018 01;141(1):23-30

Naples, Italy From the Department of Plastic, Reconstructive and Aesthetic Surgery, the Department of Experimental Medicine, Section of Virology and Microbiology, Università della Campania Luigi Vanvitelli; the Unit of Plastic, Reconstructive and Aesthetic Surgery, Università Federico II; and the Department of Public Health.

Background: Capsular contracture around breast implants is a severe and unpredictable complication experienced by up to 50 percent of patients after breast augmentation and reconstruction, and represents a major cause leading to reoperation. Several lines of evidence point to the involvement of subclinical infections and of bacterial biofilm formation.

Methods: To reduce the incidence of capsular contracture following mammaplasty, the authors studied the correlation between contamination by exogenous and endogenous bacterial flora and the capacity to develop bacterial biofilm in mammary implants. Read More

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http://dx.doi.org/10.1097/PRS.0000000000003915DOI Listing
January 2018
13 Reads

Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis.

Acta Dermatovenerol Croat 2017 Oct;25(3):248-250

Prof. Romana Čeović, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology School of Medicine, University of Zagreb, 10000 Zagreb, Šalata 4, Croatia;

Dear Editor, the association between lymphomas and autoimmune manifestations, as well as the prevalence of the cases of coexistent lymphomas and autoimmune conditions, has not been completely established (1-3). Since cutaneous T-cell lymphoma (CTCL) cases are rare, any hypothesis can only be based on case reports or small case series. We present the case of a male patient with folliculotropic mycosis fungoides (FMF) and synchronous autoimmune hepatitis (AIH) with extremely high levels of cancer antigen 19-9 (CA 19-9). Read More

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October 2017
78 Reads

Effect of 1064-nm Q-switched Nd:YAG laser on invasiveness and innate immune response in keratinocytes infected with Candida albicans.

Lasers Med Sci 2018 Jul 14;33(5):941-948. Epub 2017 Dec 14.

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania "Luigi Vanvitelli", Naples, Italy.

Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal side effects. Read More

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http://dx.doi.org/10.1007/s10103-017-2407-3DOI Listing
July 2018
11 Reads

Risks of Ruxolitinib in Gain-of-Function-Associated Severe Fungal Disease.

Open Forum Infect Dis 2017 22;4(4):ofx202. Epub 2017 Sep 22.

Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Immunology, National Institutes of Health, Bethesda, Maryland.

Heterozygous gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 GOF patients with severe invasive or cutaneous fungal infections. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofx20
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http://dx.doi.org/10.1093/ofid/ofx202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714179PMC
September 2017
33 Reads

Common Child and Adolescent Cutaneous Infestations and Fungal Infections.

Curr Probl Pediatr Adolesc Health Care 2018 01 6;48(1):3-25. Epub 2017 Dec 6.

Department of Dermatology, Wright State University, Boonshoft School of Medicine, Dayton, OH.

Cutaneous infections and infestations are common among children and adolescents. Ectoparasitic infestations affect individuals across the globe. Head lice, body lice, scabies, and infestations with bed bugs are seen in individuals who reside in both resource poor areas and in developed countries. Read More

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http://dx.doi.org/10.1016/j.cppeds.2017.11.001DOI Listing
January 2018
13 Reads

Luliconazole, a new antifungal against Candida species isolated from different sources.

J Mycol Med 2018 Jun 29;28(2):374-378. Epub 2017 Nov 29.

Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Golestan BLV, Ahvaz, Iran. Electronic address:

Objective: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials. Read More

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http://dx.doi.org/10.1016/j.mycmed.2017.11.004DOI Listing
June 2018
9 Reads

Dermatologic manifestations of endocrine disorders.

Transl Pediatr 2017 Oct;6(4):300-312

The Ohio State University College of Medicine, Columbus, OH, USA.

The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

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http://dx.doi.org/10.21037/tp.2017.09.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682371PMC
October 2017
26 Reads

Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review.

Mycopathologia 2018 Apr 22;183(2):417-421. Epub 2017 Nov 22.

Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158, Shangtang Road, Hangzhou, 310014, Zhejiang, China.

The incidence of candidiasis due to non-albicans Candida species (especially Candida glabrata) has significantly increased in recent decades. Candida glabrata often invades immunocompromised hosts and causes systemic or mucosal infections, whereas cutaneous infections are rarely reported. We present a rare case of cutaneous infection caused by C. Read More

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http://dx.doi.org/10.1007/s11046-017-0228-3DOI Listing
April 2018
5 Reads

Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions.

J Cytol 2017 Oct-Dec;34(4):179-182

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections.

Materials And Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). Read More

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http://dx.doi.org/10.4103/JOC.JOC_88_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655652PMC
November 2017
11 Reads
0.413 Impact Factor

High prevalence of candiduria due to non-albicans Candida species among diabetic patients: A matter of concern?

J Clin Lab Anal 2018 May 27;32(4):e22343. Epub 2017 Oct 27.

School of Life and Environmental Sciences, Faculty of Science Engineering and Built Environment, Deakin University, Burwood, Australia.

Background: Among the fungal pathogens, Candida species are the most common cause of urinary tract infection (UTI). Some predisposing factors such as diabetes mellitus, urinary retention, urinary stasis, renal transplantation, and hospitalization can increase the risk of candiduria. The aim of this cross-sectional study was to evaluate candiduria among type 2 diabetic patients and identification of the Candida isolates. Read More

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http://dx.doi.org/10.1002/jcla.22343DOI Listing
May 2018
3 Reads
2 Citations
1.144 Impact Factor

Cutaneous Candidiasis in a Gottingen Minipig: A Potential Pitfall in Preclinical Studies.

Toxicol Pathol 2017 12 20;45(8):1032-1034. Epub 2017 Sep 20.

3 Toxicologic Pathology, Sackler School of Medicine, Tel Aviv University, Timrat, Israel.

The Göttingen minipig is often used in preclinical toxicity studies. Therefore, knowledge of spontaneously occurring pathologies is important to differentiate them from test drug-related effects. We report on a Göttingen minipig, which developed exudating widespread dermatitis during a preclinical toxicity study with a subcutaneously injected drug. Read More

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http://dx.doi.org/10.1177/0192623317732295DOI Listing
December 2017
3 Reads

Acute disseminated candidiasis with skin lesions: a systematic review.

Authors:
M Guarana M Nucci

Clin Microbiol Infect 2018 Mar 25;24(3):246-250. Epub 2017 Aug 25.

University Hospital, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

Background: Neutropenic patients developing acute disseminated candidiasis may present with skin lesions.

Aims: To evaluate the epidemiology of acute disseminated candidiasis with skin lesions in neutropenic patients, taking into consideration changes caused by different prophylactic strategies.

Sources: A systematic review of English-language articles found via PubMed (1963-2016) was performed. Read More

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http://dx.doi.org/10.1016/j.cmi.2017.08.016DOI Listing
March 2018
2 Reads

Refractory Intertrigo in the Right Inguinal Crease: Challenge.

Am J Dermatopathol 2017 Aug;39(8):629

*Department of Medicine, Southern California Permanente Medical Group, Fontana Medical Center, Fontana, CA; †Department of Pathology, Southern California Permanente Medical Group, Sunset Medical Center, Los Angeles, CA; and ‡Internal Medicine Residency Program, State University New York, Downstate, Brooklyn, NY.

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http://dx.doi.org/10.1097/DAD.0000000000000544DOI Listing
August 2017
4 Reads

Use of cost effective and rapid molecular tools for identification of species, opportunistic pathogens.

Curr Med Mycol 2016 Sep;2(3):1-4

Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Background And Purpose: Candidiasis is a widespread fungal infection caused by different species. Rapid identification of species in clinical laboratory is becoming increasingly important since the identification and discrimination of ethological agents for early treatment. We aimed at molecular identification of commonly species isolated from clinical samples by using both PCR-RFLP assay and amplification of hwp1 gene. Read More

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http://dx.doi.org/10.18869/acadpub.cmm.2.3.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490282PMC
September 2016
9 Reads

Fenticonazole: an effective topical treatment for superficial mycoses as the first-step of antifungal stewardship program.

Eur Rev Med Pharmacol Sci 2017 06;21(11):2749-2756

Infectious Diseases Unit Teaching Hospital S. Orsola-Malpighi, Alma Mater Studiorum University of Bologna, Bologna, Italy.

The resistance of microorganisms to antimicrobial drugs is a major issue for public health, with important consequences in terms of morbidity, mortality and resource use. The phenomenon is so serious that in some areas of the world resistant strains to all available drugs have been selected. Many conditions may result in the development of resistance: they include the indiscriminate or inappropriate (e. Read More

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June 2017
24 Reads

Infection and tissue repair of experimental cutaneous candidiasis in diabetic mice.

J Med Microbiol 2017 Jun 13;66(6):808-815. Epub 2017 Jun 13.

1​Department of Pathological Sciences, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380 - 86057-970, Londrina, PR, Brazil.

Purpose: Diabetic patients seem to be predisposed to cutaneous candidiasis. In this study, we evaluated the interference of diabetic conditions in alloxan-induced diabetic mice in relation to the development of C. albicans infection, density of M1 and M2 macrophages, distribution of collagen type I and III and anti-inflamamatory cytokines involved in tissue repair. Read More

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http://dx.doi.org/10.1099/jmm.0.000496DOI Listing
June 2017
28 Reads

Disseminated Cutaneous Trichosporonosis in an Adult Bone Marrow Transplant Patient.

Indian Dermatol Online J 2017 May-Jun;8(3):192-194

Department of Dermatology, National University Health System, Singapore.

The species are yeast-like opportunistic pathogens in immunocompromised patients. infections have been reported in pediatric bone marrow transplant (BMT) patients. However, its incidence is low in the adult literature. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_92_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447339PMC
June 2017
16 Reads

Influence of low-level laser on pain and inflammation in type 2 diabetes mellitus with diabetic dermopathy - A case report.

J Cosmet Laser Ther 2017 Oct 11;19(6):360-363. Epub 2017 May 11.

a Kasturba Medical College (KMC), Manipal University , Manipal , India.

Numerous skin lesions have been commonly observed in individuals with diabetes mellitus. The common skin manifestations of diabetes mellitus are erythrasma, xanthomatosis, xanthelasma, phycomycetes and cutaneous infections like furuncolosis, candidiasis, carbuncle, dermatophytosis, etc. Diabetic dermopathy is the most common skin lesion found in patients with diabetes. Read More

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http://dx.doi.org/10.1080/14764172.2017.1326611DOI Listing
October 2017
40 Reads

Effect of long-term exposure of mice to 900 MHz GSM radiation on experimental cutaneous candidiasis.

Saudi J Biol Sci 2017 May 2;24(4):907-914. Epub 2016 Jan 2.

Department of Pathobiology, Faculty of Veterinary Specialized Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran.

Mobile phones communicate with base stations using 900 MHz microwaves. The current study was aimed to survey the effects of long-term 900 MHz microwave exposure of mice on experimentally induced cutaneous candidiasis. Forty inbred, male, BALB/c mice were randomly divided into four groups. Read More

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http://dx.doi.org/10.1016/j.sjbs.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415128PMC
May 2017
9 Reads

Case of recurrent severe cellulitis and cutaneous candidiasis during psoriasis treatment with ustekinumab.

J Dermatol 2017 Aug 22;44(8):e206-e207. Epub 2017 Apr 22.

Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1111/1346-8138.13884DOI Listing
August 2017
1 Read

Differential Diagnosis of Diaper Dermatitis.

Authors:
Bernard Cohen

Clin Pediatr (Phila) 2017 May;56(5_suppl):16S-22S

1 Johns Hopkins Children's Center, Baltimore, MD, USA.

Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Read More

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http://journals.sagepub.com/doi/10.1177/0009922817706982
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http://dx.doi.org/10.1177/0009922817706982DOI Listing
May 2017
18 Reads

Cutaneous septic emboli from Candida glabrata in a haematological patient.

Am J Hematol 2017 Oct 9;92(10):1111-1112. Epub 2017 May 9.

Infectious and Tropical Diseases Unit, IRCCS "San Matteo", Pavia, Italy.

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http://dx.doi.org/10.1002/ajh.24729DOI Listing
October 2017
8 Reads