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J Fungi (Basel) 2018 Dec 12;4(4). Epub 2018 Dec 12.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte-Minas Gerais 31270-901, Brasil.

Candidiasis is an opportunistic fungal infection with being the most frequently isolated species. Treatment of these infections is challenging due to resistance that can develop during therapy, and the limited number of available antifungal compounds. Given this situation, the aim of this study was to evaluate the antifungal activity of four thiazolylhydrazone compounds against . Read More

Med Mycol 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.

The current study aims to compare between the types of yeasts that cause vulvovaginal candidiasis (VVC) in women using corticosteroid medication compared to nonusers and estimate their sensitivity to available commercial antifungal agents. In a descriptive analytical cross-sectional study, we recruited 41 chronic corticosteroid users diagnosed clinically to have VVC from Women's Health Hospital, Assiut University, Egypt. Forty-seven age-matched women with VVC were recruited as a control group. Read More

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Division of Pediatric Allergy/Immunology, Marmara University, Fevzi Çakmak Mah. No: 41, Pendik, Istanbul, Turkey.

Purpose: Human signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations present with a broad range of manifestations ranging from chronic mucocutaneous candidiasis and autoimmunity to combined immunodeficiency (CID). So far, there is very limited experience with hematopoietic stem cell transplantation (HSCT) as a therapeutic modality in this disorder. Here, we describe two patients with heterozygous STAT1 GOF mutations mimicking CID who were treated with HSCT. Read More

Iran J Public Health 2018 Oct;47(10):1511-1519

Dept. of Gynecology, Women & Children's Health Care Hospital of Linyi, Linyi, China.

Background: We aimed to investigate the influence of nursing intervention on recurrent vulvovaginal candidiasis (RVVC) patients treated with adenosine triphosphate (ATP)-infrared bio-effect technique.

Methods: Sixty eight RVVC patients of Women & Children's Health Care Hospital of Linyi were randomly divided into intervention group (n=34) and control group (n=34) from to June, 2016 to June 2017. Patients in intervention group received the one-to-one intervention based on ATP-infrared bio-effect technique; the individualized nursing intervention program was developed. Read More

Front Microbiol 2018 20;9:2717. Epub 2018 Nov 20.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

is a notable pathogenic fungus that causes invasive candidiasis, mainly due to its natural resistance to fluconazole. However, to date, there is limited research on the genetic population features of . We developed a set of microsatellite markers for this organism, with a cumulative discriminatory power of 1,000. Read More

Infect Drug Resist 2018 23;11:2443-2448. Epub 2018 Nov 23.

Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Manipal, India.

Introduction: species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various species and slime production by species in BSIs and vulvovaginal candidiasis (VVC).

Materials And Methods: A total of 176 samples were collected for a period of 1 year. Read More

Nat Commun 2018 12 11;9(1):5288. Epub 2018 Dec 11.

School of Biosciences, University of Exeter, Geoffrey Pope Building, Exeter, EX4 4QD, UK.

The high global burden of over one million annual lethal fungal infections reflects a lack of protective vaccines, late diagnosis and inadequate chemotherapy. Here, we have generated a unique set of fully human anti-Candida monoclonal antibodies (mAbs) with diagnostic and therapeutic potential by expressing recombinant antibodies from genes cloned from the B cells of patients suffering from candidiasis. Single class switched memory B cells isolated from donors serum-positive for anti-Candida IgG were differentiated in vitro and screened against recombinant Candida albicans Hyr1 cell wall protein and whole fungal cell wall preparations. Read More

J Prosthodont 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY.

Purpose: Denture stomatitis is a common condition manifested by inflammation of the oral mucous membrane beneath a denture. The objective of this study was to compare the transcriptome of human palatal mucosa with chronic oral stomatitis-associated Candida albicans infection to that of healthy oral mucosa.

Materials And Methods: Oral palatal biopsies were obtained from 17 healthy and 15 C. Read More

Exp Suppl 2018 ;108:153-176

Departament Periodontology, Facultad de Odontología, Universidad de Sevilla, Sevilla, Spain.

One of the main steps in the development of the life in the earth is multicellularity. It enables cell differentiation and the development of morphological structures within an organism and is an essential factor in how to recognize friendly cells that are part of the multicellular organism and which foreign organisms can be harmful. Recognition includes devices such as the major histocompatibility complex (MHC), and the pattern recognition receptors (PRRs). Read More

Rev Chilena Infectol 2018 Aug;35(4):377-385

División de Estudios de Posgrado e Investigación, Facultad de Odontología, UNAM, México.

Background: Factors associated with candidiasis and colonization in HIV-positive children and adolescents in developing countries are not well understood.

Aim: To identify the factors associated with oral Candida colonization and candidiasis in institutionalized HIV-positive children and adolescents in Tijuana, México, as well as the response of the isolates to antifungals.

Materials And Methods: Sample of the oral mucosa of 30 HIV positive children and adolescents were obtained to isolate and identify Candida species by culture and metabolic profile. Read More

Colloids Surf B Biointerfaces 2018 Nov 29;175:166-174. Epub 2018 Nov 29.

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 645 Diagonal Ave., 08028 Barcelona, Spain. Electronic address:

Clotrimazole (CLT) was formulated in a multiple W/O/W emulsion (ME) with the aim of evaluating its potential as topical anticandidal agent and comparing with marketed products. A previously evaluated CLT-ME was selected and physicochemically characterized. The in vitro release behavior and the ex vivo permeation profiles were assessed using Franz diffusion cells using three different types of biological membranes: human skin and porcine buccal, sublingual and vaginal mucosae. Read More

Bioorg Med Chem 2018 Nov 29. Epub 2018 Nov 29.

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420, rue de la Terrasse, Québec, QC G1V 0A6, Canada. Electronic address:

Microorganisms embedded in a biofilm are significantly more resistant to antimicrobial agents and the defences of the human immune system, than their planktonic counterpart. Consequently, compounds that can inhibit biofilm formation are of great interest for novel therapeutics. In this study, a screening approach was used to identify novel cyclic dipeptides that have anti-biofilm activity against oral pathogens. Read More

Orv Hetil 2018 Dec;159(49):2065-2072

I. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Bókay J. u. 53., 1083.

Experimental and clinical data suggest a complex interaction between the endocrine and immune systems. However, only few epidemiological studies are available dealing with endocrine complications in different types of primary immunodeficiency diseases. It is well documented that there is a close association between immunodeficiency syndromes and the development of autoimmune disorders. Read More

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Louisiana State University Health Sciences Center, Microbiology and Immunology.

Candida species are the second most frequent cause of fungal infections worldwide. Current knowledge of immunity to Candida has been gleaned almost exclusively from studies on Candida albicans, the most common disease-causing species. Knowledge of immunity to non-albicans Candida (NAC) species is still at an early stage due to the lack of tractable animal models with which to study these important pathogens. Read More

Front Microbiol 2018 21;9:2818. Epub 2018 Nov 21.

Laboratorio de Micología Médica, UFI 11/25, Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Bilbao, Spain.

Candidiasis is a major cause of human morbidity and mortality. Human uterine cervical stem cells conditioned medium (hUCESC-CM) is obtained from stromal stem cells of the cervical transformation zone, which are in permanent contact with a wide array of potential vaginal pathogens. In previous reports we have found that hUCESC-CM has antitumor and antibacterial potential. Read More

J Vis Exp 2018 Nov 17(141). Epub 2018 Nov 17.

Department of Microbiology, The Ohio State University; Department of Microbial Infection and Immunity, The Ohio State University;

Candida species are common fungal commensals of humans colonizing the skin, mucosal surfaces, and gastrointestinal tract. Under certain conditions, Candida can overgrow their natural niches resulting in debilitating mucosal infections as well as life-threatening systemic infections, which are a major focus of investigation due to their associated high mortality rates. Animal models of disseminated infection exist for studying disease progression and dissecting the characteristics of Candida pathogenicity. Read More

Lancet Infect Dis 2018 Nov 24;18(11):1180. Epub 2018 Oct 24.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; National Center for Sexually Transmitted Disease Control, Nanjing, China. Electronic address:

Eur J Haematol 2018 Dec 1. Epub 2018 Dec 1.

Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: Characteristics and risk factors (RFs) of invasive fungal disease (IFD) have been little studied in the setting of umbilical cord blood transplantation (UCBT).

Method: We retrospectively included 205 single-unit myeloablative UCBT recipients with a median follow-up of 64 months.

Results: Fifty-six episodes of IFD were observed in 48 patients (23%) at a median time of 123 days after stem cell infusion. Read More

Indian J Dermatol 2018 Nov-Dec;63(6):484-489

Department of VD Serology and Department of STD, Institute of Serology, Kolkata, West Bengal, India.

Context: Sexually transmitted infections (STIs) and reproductive tract infections (RTIs) constitute important public health problem worldwide. Syndromic diagnosis of vaginal/cervical discharge (VCD) is often inaccurate leading to over- or under-treatment.

Aims: This study aimed to ascertain the laboratory-confirmed diagnosis of VCD and their relative frequency in a group of patients presenting to a STI clinic in eastern India and to determine the sensitivity and specificity of clinical diagnosis. Read More

Epidemiol Infect 2018 Dec 3:1-9. Epub 2018 Dec 3.

Department of Pharmacology,University of Gothenburg,Gothenburg,Sweden.

Here we wanted to assess whether sexual risk behaviour differs dependent by human immunodeficiency virus (HIV) status by following 100 HIV- and 137 HIV+ women recruited at two university teaching hospitals in Rwanda. Women were tested for sexually transmitted infections (STIs; trichomoniasis, syphilis, hepatitis B and C) and for reproductive tract infections (RTIs; candidiasis, bacterial vaginosis (BV)) and were interviewed at baseline and 9 months later. BV was the most prevalent infection, while syphilis was the most common STI with a 9-month incidence of 10. Read More

Front Immunol 2018 20;9:2702. Epub 2018 Nov 20.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

Vulvovaginal candidiasis (VVC) is a common fungal infection caused by . The antifungal therapy represents the standard of care but due to the high costs of treatment and to the inability to prevent recurrences, the development of alternative therapeutic approaches is much-awaited. Recently, we have shown that the pathogenesis of in the gut is modulated by IL-9, a pleiotropic cytokine able to promote both inflammation and tolerance during infection. Read More

Pharmaceutics 2018 Dec 3;10(4). Epub 2018 Dec 3.

Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil.

Oral candidiasis (OC) is an infectious disease caused by microorganisms of the genus , leading to lesions in the buccal cavity. Its treatment consists of the administration of topical or systemic antifungal agents, which may compromise the patient compliance due to its side effects, highlighting the need for alternative treatments. In this scenario, bullfrog oil, an animal oil composed of a pool of saturated and unsaturated fatty acids, is introduced as a potential antifungal raw material. Read More

Front Immunol 2018 19;9:2570. Epub 2018 Nov 19.

Department Parasitology-Mycology, CHU, Lille, France.

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinoma (SCC), and may lead to death. The role of chronic infection in the etiopathogenesis of oral SCC is unclear. Read More

Pathol Oncol Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiotherapy, Oncology Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, People's Republic of China.

The management of ductal carcinoma in situ (DCIS) with endocrine therapy remains controversial. A meta-analysis was conducted to evaluate the role of endocrine therapy for DCIS with breast conserving surgery (BCS) and radiotherapy (RT). A total of 7 articles with randomized controlled trials were included. Read More

J Contemp Dent Pract 2018 Oct 1;19(10):1161-1162. Epub 2018 Oct 1.

All Smiles Dental Clinic, Besant Nagar, Chennai, India.

Mali Med 2018 ;33(2):13-16

Faculté de médecine et d'Odontostomatologie.

Introduction: Prurigo is one of the most common dermatological conditions during HIV infection and AIDS. It appears as an immunosuppression marker associated with HIV infection. The study objective was to determine the prevalence of prurigo in people living with the human immunodeficiency virus (PLHIV) in Fousseyni N'Daou Hospital of Kayes, and to describe the socio-demographic aspects of patients and lesions associated with prurigo among PLHIV. Read More

Immunobiology 2018 Nov 20. Epub 2018 Nov 20.

Department of Human Genetics, Guru Nanak Dev University, Amritsar, India. Electronic address:

Recurrent vulvovaginal infections (RVVI), owing to their adverse health consequences, have become a serious dilemma worldwide. Low serum levels of Mannose-Binding Lectin (sMBL), a main component of innate immunity, was found to be associated with RVVI risk, though complete genetic bases are still elusive. To reveal unrecognised regulatory variants, 3'-UTR region of MBL2 with six putative functional SNPs i. Read More

Colloids Surf B Biointerfaces 2018 Nov 20;174:409-415. Epub 2018 Nov 20.

Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil.

Objectives: In this study, polymeric nanoparticles based on chitosan incorporating the antifungal miconazole nitrate were fabricated and testedin vivo using murine vulvovaginal candidiasis.

Methods: Nanoparticles prepared by the ionotropic gelation method presented 200 to 300 nm diameter and polydispersity indexes ranging from 0.2 to 0. Read More

Sci Rep 2018 Nov 27;8(1):17406. Epub 2018 Nov 27.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.

Leukocyte mono-immunoglobulin-like receptor (LMIR)/CD300 proteins comprise a family of immunoglobulin-like receptors that are widely expressed on the immune cell surface in humans and mice. In general, LMIR3/CD300f suppresses the inflammatory response, but it can occasionally promote it. However, the precise roles of LMIR3 in the function of neutrophils remain to be elucidated. Read More

Antimicrob Agents Chemother 2018 Nov 26. Epub 2018 Nov 26.

Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary

In the consequence of emerging number of vulvovaginitis caused by azole-resistant and biofilm-forming species, the fast and efficient treatment of this infection has become challenging. The problem is further exacerbated by the severe side-effects of azoles as long-term use medications in the recurrent form. There is therefore an increasing demand for novel and safely applicable effective antifungal therapeutic strategies. Read More

J Antimicrob Chemother 2018 Nov 22. Epub 2018 Nov 22.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Mod Rheumatol 2018 Nov 24:1-12. Epub 2018 Nov 24.

a Inflammation and Immunology, Graduate School of Medical Science , Kyoto Prefectural University of Medicine , Kyoto , Japan.

Objective: To assess risk factors for cytomegalovirus (CMV) disease with CMV re-activation in patients with rheumatic disease.

Methods: The clinical data of consecutive patients with rheumatic disease who experienced CMV re-activation were examined. We evaluated the difference in various baseline factors at the first detection of CMV pp65 antigenemia on the development of CMV disease using logistic regression models. Read More

Clin Microbiol Infect 2018 Nov 22. Epub 2018 Nov 22.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Objective: We investigated molecular mechanisms responsible for azole resistance in Candida tropicalis isolates.

Methods: We studied 507 C. tropicalis isolates causing invasive candidiasis from 10 hospitals over five years. Read More

Rev Iberoam Micol 2018 Nov 21. Epub 2018 Nov 21.

Servicio de Microbiología, Hospital Universitari i Politècnic La Fe, Valencia, España. Electronic address:

The prognosis of invasive fungal infections (IFI) depends on the speed of diagnosis and treatment. Conventional diagnostic methods are of low sensitivity, laborious and too slow, leading to the need for new, faster, and more efficient diagnostic strategies. There are several techniques for diagnosing a candidemia that are faster than the conventional blood culture (BC). Read More

J Mycol Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Immunology, Pasteur Institute of Iran, Tehran, Iran; Recombinant Vaccine Research Center, Tehran university of Medical Sciences, Tehran, Iran. Electronic address:

Objective: The effect of candidemia on immunologic parameters in breast tumor bearing patients is not well studied. Here, we hypothesised that candidemia in the tumor background may change the outcome of immunologic parameters and tumor condition.

Method: Mice were divided into four groups, including normal, tumor, Candida infected (only Candidiasis) and tumor/Candidiasis groups. Read More

Eur J Clin Microbiol Infect Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China.

The purpose of this study was to investigate the risk factors and pregnancy outcomes for aerobic vaginitis (AV) in late pregnancy. A total of 624 pregnant women who were treated in the perinatal unit at Tianjin Medical University General Hospital and 365 nonpregnant women who were evaluated at a health management center from January 2015 to June 2016 were recruited for this case-control study. A questionnaire covering personal hygiene habits and sociodemographic factors was administered to pregnant women to analyze risk factors for AV. Read More

Rev Iberoam Micol 2018 Nov 19. Epub 2018 Nov 19.

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Bilbao, España. Electronic address:

The landscape of invasive mycoses is in a continuous evolution with important implications for their diagnosis and treatment. The overall burden remains high, particularly in neonates and the elderly, patients admitted to intensive care units, using prostheses, catheters or other intravenous devices, those receiving different immunosuppressant treatments or antineoplastic chemotherapy, or transplant recipients. In addition, opportunistic mycoses can be associated with HIV infection. Read More

Adv Clin Exp Med 2018 Nov 22. Epub 2018 Nov 22.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, Poland.

Background: Vaginitis is one of the most common problems in clinical medicine and is cited most often during visits to obstetricians and gynecologists. Most of the inflammation cases are caused by candidiasis trichomoniasis and bacterial vaginosis. Therefore, treatment of vaginal infections must use antibiotic or antifungal drugs, which often provide quick relief to the patient. Read More

Indian J Otolaryngol Head Neck Surg 2018 Dec 7;70(4):555-558. Epub 2018 Jun 7.

4Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India.

To study the change in trend of ear, nose and throat (ENT) manifestations in patients who were on treatment, before and after availability of highly active antiretroviral therapy (HAART). To find out the prevalence of ENT manifestations in human immunodeficiency virus (HIV) infected people who were on treatment, in the year of 2004 (before the availability of HAART) and in 2014 (after the availability of HAART). A combination of a retrospective and prospective study. Read More

Med Mycol 2018 Nov 21. Epub 2018 Nov 21.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Infections with Candida spp. cause significant morbidity and mortality despite intensive treatment with antifungal agents. Novel treatment options are urgently needed. Read More

Front Microbiol 2018 6;9:2641. Epub 2018 Nov 6.

School of Chemical Engineering, Yeungnam University, Gyeongsan, South Korea.

is an opportunistic fungal pathogen and most prevalent species among clinical outbreaks. It causes a range of infections, including from mild mucosal infections to serious life-threatening candidemia and disseminated candidiasis. Multiple virulence factors account for the pathogenic nature of , and its morphological transition from budding yeast to hyphal form and subsequent biofilm formation is regarded as the most important reason for the severity of infections. Read More

Sci Rep 2018 Nov 20;8(1):17123. Epub 2018 Nov 20.

Research Unit on Oral Microbiology and Immunology and Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.

Dendritic cells (DCs) abundantly express diverse receptors to recognize mannans in the outer surface of Candida cell wall, and these interactions dictate the host immune responses that determine disease outcomes. C. krusei prevalence in candidiasis worldwide has increased since this pathogen has developed multidrug resistance. Read More

Rev Iberoam Micol 2018 Nov 16. Epub 2018 Nov 16.

Servicio de Enfermedades Infecciosas, Hospital Clínic de Barcelona-IDIBAPS; Universitat de Barcelona, FungiCLINIC Research group (AGAUR), Barcelona, España. Electronic address:

The treatment of invasive fungal infections has deeply evolved in recent years with the inclusion of new antifungals to the therapeutic treatment arsenal. A new azole, isavuconazole, has been recently approved. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections: invasive candidiasis, aspergillosis, mucormicosis, infections caused by other filamentous fungi and those caused by dimorphic fungi. Read More

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

Chem Biol Drug Des 2018 Nov 19. Epub 2018 Nov 19.

Pharmaceutical Synthesis Group (PHARSG), Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

The combination of tools such as time-kill assay with subsequent application of mathematical modeling can clarify the potential of new antimicrobial compounds, since minimal inhibitory concentration (MIC) value does not provide a very detailed characterization of antimicrobial activity. Recently, our group has reported that the 8-hydroxy-5-quinolinesulfonic acid presents relevant antifungal activity. However, its intrinsic acidity could lead to an ionization process, decreasing fungal cell permeability. Read More

J Antibiot (Tokyo) 2018 Nov 19. Epub 2018 Nov 19.

Department of Microbiology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 9 Maria Curie-Skłodowska Street, 85-094, Bydgoszcz, Poland.

According to the available literature, echinocandins display high anti-Candida spp. activity. Paradoxical growth (PG) of Candida spp. Read More

Colloids Surf B Biointerfaces 2018 Nov 7;174:110-125. Epub 2018 Nov 7.

Department of Ecology of Pathogen Agents, Hospital Manuel Gea González, Mexico City, Mexico.

Candida species, including C. albicans, are part of the mucosal flora of most healthy women, and inhabit the gastrointestinal and genitourinary tracts. Under favourable conditions, they can colonize the vulvovaginal mucosa, giving rise to symptomatic vulvovaginal candidiasis (VVC). Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):929-932

Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China (Zhao HY, Wu PH, Wang GJ, Wang HX, Zhu FX, An YZ); Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China (Wang Q). Corresponding author: An Youzhong, Email:

Objective: To investigate the clinical characteristics and predictors of mortality in patients with candidemia in intensive care unit (ICU).

Methods: The patients with candidemia admitted to ICU of Peking University People's Hospital from January 2010 to December 2017 were enrolled. The general clinical data, indicators related to Candidia infection and prognosis were collected, and the clinical characteristics, infection characteristics and prognosis of patients with candidiasis were analyzed. Read More

Acta Clin Croat 2018 Jun;57(2):342-351

Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g. Read More

Curr Top Med Chem 2018 Nov 14. Epub 2018 Nov 14.

Federal University of Paraíba, Campus I, João Pessoa-PB. Brazil.

Aims: The objective of this study was to investigate the effectiveness of (+)-β-pinene inhibition onCandida spp. growth,aiming at elucidation of the mechanism of action; to determinefungal cell enzymebinding activity (through molecular docking simulations) and its effects on biofilm reduction.

Methodology: Candidastrains (n=26)from referencedand clinical origins, eithersusceptible or resistant to standard clinical antifungals, were tested for determination of Minimum Inhibitory Concentration (MIC); Minimum Fungicidal Concentration (MFC); and microbial death curves upon treatment with (+)-β-pinene; the effects of (+)-β-pinene on the cell wall (sorbitol assay), membrane ergosterol binding, and effects on biofilm wereevaluatedby microdilution techniques. Read More