35,996 results match your criteria Candidiasis


Molecular crypsis by pathogenic fungi using human factor H. A numerical model.

PLoS One 2019 19;14(2):e0212187. Epub 2019 Feb 19.

Dept. of Bioinformatics, Friedrich Schiller University Jena, Jena, Germany.

Molecular mimicry is the formation of specific molecules by microbial pathogens to avoid recognition and attack by the immune system of the host. Several pathogenic Ascomycota and Zygomycota show such a behaviour by utilizing human complement factor H to hide in the blood stream. We call this type of mimicry molecular crypsis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212187PLOS
February 2019

Clinical, Immunological, and Molecular Findings in 57 Patients With Severe Combined Immunodeficiency (SCID) From India.

Front Immunol 2019 4;10:23. Epub 2019 Feb 4.

Department of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.

Severe combined immunodeficiency (SCID) represents one of the most severe forms of primary immunodeficiency (PID) disorders characterized by impaired cellular and humoral immune responses. Here, we report the clinical, immunological, and molecular findings in 57 patients diagnosed with SCID from India. Majority of our patients (89%) presented within 6 months of age. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369708PMC
February 2019

Danger signals in oral cavity-related diseases.

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.

The oral cavity is a unique environment containing teeth juxtaposed with soft tissues, all of which are constantly bathed in microbial products and host-derived factors. While microbial dysbiosis in the oral cavity clearly leads to oral inflammatory disease, recent advances find that endogenous danger-associated molecular patterns (DAMPs) released from oral and salivary tissue also contribute to the progression of inflammatory and autoimmune disease, respectively. In contrast, DAMPs produced during oral fungal infection actually promote the resolution of infection. Read More

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http://dx.doi.org/10.1002/JLB.4MIR1118-439RDOI Listing
February 2019

Candida auris - the growing menace to global health.

Mycoses 2019 Feb 17. Epub 2019 Feb 17.

Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.

A paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of C. auris. C. Read More

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http://dx.doi.org/10.1111/myc.12904DOI Listing
February 2019

Primary and secondary prevention of preterm birth: a review of systematic reviews and ongoing randomized controlled trials.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 25. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Dalhousie University, Halifax Nova Scotia, Canada.

Background: Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality. Interventions aimed at preventing PTB can be classified as primary, secondary, or tertiary prevention.

Objective: To conduct a review of systematic reviews on the effectiveness and safety of primary and secondary preterm birth prevention interventions. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.022DOI Listing
January 2019

Autoimmune Regulator (AIRE) is required in female mice for optimal embryonic development and implantation1.

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Dept. Pathobiology & Diagnostic Investigation, and.

Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice results in multi-organ autoimmune disease, known in humans as Autoimmune Polyglandular Syndrome Type 1 (APS-1). APS-1 is characterized by presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz023DOI Listing
February 2019
1 Read

Susceptibility to Oral Antiseptics and Virulence Factors Ex Vivo Associated with Candida spp. Isolated from Dental Prostheses.

J Prosthodont 2019 Feb 15. Epub 2019 Feb 15.

School of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, Brazil.

Purpose: To isolate Candida spp. from dental prosthesis users' saliva and to evaluate the isolates for the presence of several virulence factors. This research also aimed to investigate the antifungal activity of 3 commercial mouthwashes/oral antiseptic formulations containing 0. Read More

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http://dx.doi.org/10.1111/jopr.13037DOI Listing
February 2019

Effectiveness and Safety of Micafungin in Managing Invasive Fungal Infections among Patients in Greece with Hematologic Disorders: The ASPIRE Study.

Infect Dis Ther 2019 Feb 14. Epub 2019 Feb 14.

University General Hospital of Larissa, Larissa, Greece.

Introduction: Invasive candidiasis (IC) can be a life-threatening infection in immunocompromised patients, particularly those with cancer, hematologic diseases and/or hematopoietic stem cell transplantation (HSCT) recipients. The objective of this study was to evaluate the effectiveness of micafungin in patients with hematologic malignancies or HSCT recipients, relevant to clinical presentation of IC, in real-life practice in Greece.

Methods: ASPIRE was a phase IV, multicenter, non-interventional, prospective cohort study, conducted at ten tertiary hospitals in Greece, in adults with hematologic disease. Read More

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http://dx.doi.org/10.1007/s40121-019-0236-3DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019
1 Read

Genital Infections with Sodium Glucose Cotransporter-2 Inhibitors: Occurrence and Management in Patients with Type 2 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):837-842

Medical Affairs, AstraZeneca Pharma India Ltd., Bengaluru, Karnataka, India.

Diabetes is a metabolic disorder characterized by hyperglycemia and is associated with several comorbidities and complications. Genital infection is one such complication that is often associated with diabetes mellitus (DM). Even though abnormalities in immune system, high urine glucose, and bladder dysfunction are important contributors for the increased risk of genitourinary symptoms, yet the possible role of pharmacologically induced glucosuria cannot be completely overlooked in such patients. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_159_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330876PMC
February 2019

Linezolid in Combination With Azoles Induced Synergistic Effects Against and Protected Against Experimental Candidiasis.

Front Microbiol 2018 31;9:3142. Epub 2019 Jan 31.

Department of Pharmacy, Qianfoshan Hospital Affiliated to Shandong University, Ji'nan, China.

The incidence of resistant isolates has increased continuously in recent decades, especially . To overcome this resistance, research on antifungal sensitizers has attracted considerable attention. Linezolid was found to inhibit the growth of and synergize with amphotericin B against . Read More

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http://dx.doi.org/10.3389/fmicb.2018.03142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365414PMC
January 2019

Invasive fungal infection in crtically ill patients: hurdles and next challenges.

J Chemother 2019 Feb 14:1-10. Epub 2019 Feb 14.

g Intensive Care Unit , Hospital Universitario Dr. Peset , Valencia , Spain.

A narrative review from a multidisciplinary task force of experts in critical care medicine and clinical mycology was carried out. The multi drug-resistant species Candida auris has emerged simultaneously on several continents, causing hospital outbreaks, especially in critically ill patients. Although there are not enough data to support the routine use of continuous antibiotic prophylaxis in patients subjected to extracorporeal membrane oxygenator, a clear increase of invasive fungal infection (IFI) has been described with the use of this device. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1557799DOI Listing
February 2019
3 Reads

Anticandidal activities of lactic acid bacteria isolated from the vagina

Turk J Med Sci 2019 Feb 11;49(1):375-383. Epub 2019 Feb 11.

Background/aim: Lactic acid bacteria prevent the overgrowth of pathogenic agents and opportunistic pathogens in the vagina. Moreover, lactic acid bacteria contribute to the preservation of vaginal microbiota by producing antimicrobial agents. Previous studies showed that some lactic acid bacteria exhibited antimicrobial activity against Candida species causing yeast vaginosis as well as many bacterial pathogens. Read More

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http://dx.doi.org/10.3906/sag-1709-143DOI Listing
February 2019
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Autophagy-Inducing Factor Atg1 Is Required for Virulence in the Pathogenic Fungus .

Front Microbiol 2019 25;10:27. Epub 2019 Jan 25.

Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

is one of the leading causes of candidiasis and serious invasive infections in hosts with weakened immune systems. is a haploid budding yeast that resides in healthy hosts. Little is known about the mechanisms of virulence. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00027
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http://dx.doi.org/10.3389/fmicb.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362428PMC
January 2019
1 Read

The serine peptidase inhibitor TPCK induces several morphophysiological changes in the opportunistic fungal pathogen Candida parapsilosis sensu stricto.

Med Mycol 2019 Feb 9. Epub 2019 Feb 9.

Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Candida parapsilosis sensu stricto (C. parapsilosis) has emerged as the second/third commonest Candida species isolated from hospitals worldwide. Candida spp. Read More

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http://dx.doi.org/10.1093/mmy/myz008DOI Listing
February 2019

Efficacy of T-2307, a novel arylamidine, against ocular complications of disseminated candidiasis in mice.

J Antimicrob Chemother 2019 Feb 7. Epub 2019 Feb 7.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.

Objectives: T-2307, a novel arylamidine, shows broad-spectrum activity against pathogenic fungi, including Candida albicans. Ocular candidiasis is one of the serious complications associated with Candida bloodstream infection and is known to be refractory to conventional antifungal agents. The aim of the present study was to clarify the effectiveness of T-2307 against ocular candidiasis using a mouse model. Read More

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http://dx.doi.org/10.1093/jac/dkz020DOI Listing
February 2019

Antifungal activity of analogues of antimicrobial peptides isolated from bee venoms against vulvovaginal Candida spp.

FEMS Yeast Res 2019 Feb 11. Epub 2019 Feb 11.

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo námestí 2, 166 10, Prague 6, Czech Republic.

Candida albicans is the main causative agent of vulvovaginal candidiasis, a common mycosis in women, relapses of which are difficult to manage due to biofilm formation. This study aimed to develop novel non-toxic compounds active against Candida spp. biofilms. Read More

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http://dx.doi.org/10.1093/femsyr/foz013DOI Listing
February 2019

Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.

J Immunol 2019 Feb 11. Epub 2019 Feb 11.

Immunology Discovery, Janssen Research and Development, LLC, Spring House, PA 19477;

The cytokines TNF-α and IL-17A are elevated in a variety of autoimmune diseases, including rheumatoid arthritis. Both cytokines are targets of several biologic drugs used in the clinic, but unfortunately many patients are refractory to these therapies. IL-17A and TNF-α are known to mediate signaling synergistically to drive expression of inflammatory genes. Read More

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http://dx.doi.org/10.4049/jimmunol.1801436DOI Listing
February 2019
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NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans.

J Pharm Biomed Anal 2019 Jan 30;167:15-20. Epub 2019 Jan 30.

Instituto de Biología Agrícola de Mendoza (IBAM-CONICET), Facultad de Ciencias Agrarias, Universidad Nacional de Cuyo, Mendoza, Argentina.

Candida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract and vagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern over the emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.01.026DOI Listing
January 2019
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Candida albicans-associated sepsis in a pre-term neonatal rhesus macaque (Macaca mulatta).

J Med Primatol 2019 Feb 8. Epub 2019 Feb 8.

Oregon National Primate Research Center, Division of Comparative Medicine, Oregon Health & Science University, Portland, Oregon.

Invasive Candida infections (ICI) have been associated with neurodevelopmental impairment or death in human pre-term neonates. Candidiasis in nonhuman primates is seen mostly in immunosuppressed animals, and ICI is not commonly reported. Here, we report a case of Candida albicans-associated ICI in a pre-term neonatal rhesus macaque. Read More

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http://doi.wiley.com/10.1111/jmp.12401
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http://dx.doi.org/10.1111/jmp.12401DOI Listing
February 2019
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Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background And Aims: Herpes simplex esophagitis (HSE) is the second most common cause of infectious esophagitis and occurs in both immunocompetent and immunocompromised patients. The aim of this study was to reappraise the clinical course of HSE in different patient populations based on degree of immunocompetence and the presence or absence of underlying esophageal disease.

Methods: Patients with histopathologically confirmed HSE identified from the Mayo Clinic pathology database from 2006 to 2016 were included in this study. Read More

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http://link.springer.com/10.1007/s10620-019-05493-x
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http://dx.doi.org/10.1007/s10620-019-05493-xDOI Listing
February 2019
3 Reads

A Study of Pap Smears in HIV-Positive and HIV-Negative Women from a Tertiary Care Center in South India.

Acta Cytol 2019 Feb 5:1-6. Epub 2019 Feb 5.

Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India.

Objectives: The aim of this work was to study the spectrum of epithelial abnormalities on Pap smears of HIV-positive women categorized as per the Bethesda System of Reporting Cervical Cytology, to correlate them with CD4 lymphocyte counts, and to compare them with the spectrum of abnormalities seen in a HIV-negative control group. Study Design and Methodology: The present study was a 6-year retrospective study conducted in the Department of Pathology at Kasturba Medical College, Mangalore, which included 150 Pap smears from HIV-positive and HIV-negative women, respectively. The Pap-stained slides of the cases were retrieved and studied. Read More

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http://dx.doi.org/10.1159/000496211DOI Listing
February 2019
4 Reads

β-1,3-Glucan/CR3/SYK pathway-dependent LC3B-II accumulation enhanced the fungicidal activity in human neutrophils.

J Microbiol 2019 Feb 5. Epub 2019 Feb 5.

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, 300387, P. R. China.

Since molecular genotyping has been established for the Candida species, studies have found that a single Candida strain (endemic strain) can persist over a long period of time and results in the spread of nosocomial invasive candidiasis without general characteristics of horizontal transmissions. Our previous study also found the existence of endemic strains in a cancer center in Tianjin, China. In the current study, we performed further investigation on endemic and non-endemic Candida albicans strains, with the aim of explaining the higher morbidity of endemic strains. Read More

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http://dx.doi.org/10.1007/s12275-019-8298-1DOI Listing
February 2019
2 Reads

[Ocular lesions in HIV-infected patients of the ophthalmic hospitals].

Vestn Oftalmol 2018 ;134(6):25-32

Perm State Medical University named after E.A. Wagner, 26 Petropavlovskaya St., Perm, Russian Federation, 614000; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 91 Pervomaiskaya St., Yekaterinburg, Russian Federation, 620041.

Purpose: To analyze ophthalmic pathologies in HIV-infected patients of the ophthalmic hospitals of Perm city.

Material And Methods: Medical records of 75 HIV patients registered in Perm Regional Centre for Prevention and Control of AIDS and Infectious Diseases who had received treatment in ophthalmic in-patient clinics of Perm in 2005-2015 years were analyzed retrospectively. Patient examination included traditional ophthalmological methods, as well as immunological (determination of CD4 cells and viral load), serological (detection of antibodies to herpes simplex virus, cytomegalovirus, chlamydia, toxoplasma), general clinical methods, and consultations by allied specialists. Read More

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http://dx.doi.org/10.17116/oftalma201813406125DOI Listing
January 2018
5 Reads

Iron Chelator Deferasirox Reduces Invasion of Oral Epithelial Cells and Infection Levels in Murine Oropharyngeal Candidiasis.

Antimicrob Agents Chemother 2019 Feb 4. Epub 2019 Feb 4.

Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, 14214, United States of America.

, the causative agent of mucosal infections including oropharyngeal candidiasis (OPC) as well as bloodstream infections is becoming increasingly resistant to existing treatment options. In the absence of novel drug candidates, drug repurposing aimed at using existing drugs to treat off label diseases is a promising strategy. requires environmental iron for survival and virulence while host nutritional immunity deploys iron-binding proteins to sequester iron and reduce fungal growth. Read More

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http://dx.doi.org/10.1128/AAC.02152-18DOI Listing
February 2019
2 Reads

Molecular, Immunological, and Clinical Features of 16 Iranian Patients with Mendelian Susceptibility to Mycobacterial Disease.

J Clin Immunol 2019 Feb 4. Epub 2019 Feb 4.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, 4th Floor, Building no.3, Children's Medical Center, Gharib St, Keshavarz Blvd, 14185-863, Tehran, IR, 14194, Iran.

Purpose: Mendelian susceptibility to mycobacterial disease (MSMD) is a rare primary immunodeficiency, triggered by non-tuberculous mycobacteria or Bacillus Calmette-Guérin (BCG) vaccines and characterized by severe diseases. All known genetic etiologies are inborn errors of IFN-γ-mediated immunity. Here, we report the molecular, cellular, and clinical features of patients from 15 Iranian families with disseminated disease without vaccination (2 patients) or following live BCG vaccination (14 patients). Read More

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http://link.springer.com/10.1007/s10875-019-0593-4
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http://dx.doi.org/10.1007/s10875-019-0593-4DOI Listing
February 2019
3 Reads

Probiotics and vaginal microecology: fact or fancy?

BMC Womens Health 2019 Jan 31;19(1):25. Epub 2019 Jan 31.

Gynaecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda, 12 - 20122, Milan, Italy.

Background: Probiotics are live microorganisms that, when administered in adequate amounts, should confer a health benefit to the host. Media sources tend to present probiotics as an appealing health promotion method able to prevent or treat a wide variety of clinical conditions. In obstetrics and gynaecology, Lactobacilli species are mainly used to restore the physiologic vaginal microbiota in order to treat bacterial vaginosis and vulvovaginal candidiasis (VVC) and prevent preterm birth. Read More

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http://dx.doi.org/10.1186/s12905-019-0723-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357464PMC
January 2019
1 Read

Opportunistic diseases in patients with HIV infection in the intensive care unit.

Ter Arkh 2018 Nov;90(11):13-17

Peoples Friendship University of Russia (RUDN University), Moscow, Russia.

Aim: The aim of the study was to analyze the incidence and prevalence of opportunistic diseases and comorbidities in patients admitted in the intensive care unit.

Materials And Methods: A specialized intensive care unit (ICU) for patients with severe HIV infection was set up in 2014 at the infectious diseases 2nd state hospital Moscow. It provides intensive care and treatments for HIV patients with severe co-morbidities and opportunistic infections. Read More

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http://dx.doi.org/10.26442/terarkh2018901113-17DOI Listing
November 2018
5 Reads

Effect of Mongolian Herbal Tea on Growth of Candida albicans.

Bull Tokyo Dent Coll 2019 Jan 31. Epub 2019 Jan 31.

Department of Clinical Pathophysiology, Tokyo Dental College.

Candida albicans, one of the main pathogens in the oral cavity, is involved in the development of oral candidiasis. Various components of tea, and especially polyphenols, are believed to be effective against the growth of yeast or bacteria. The purpose of this study was to investigate the effect of polyphenols in Mongolian herbal tea on growth of C. Read More

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http://dx.doi.org/10.2209/tdcpublication.2018-0021DOI Listing
January 2019

Candidiasis: Red and White Manifestations in the Oral Cavity.

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Oral Pathology Radiology and Medicine, The University of Iowa College of Dentistry, S386 Dental Science Building, Iowa City, IA, 52242, USA.

Candidiasis is a very common malady in the head neck region. This review will concentrate on intraoral, pharyngeal and perioral manifestations and treatment. A history of the origins associated with candidiasis will be introduced. Read More

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http://dx.doi.org/10.1007/s12105-019-01004-6DOI Listing
January 2019

Inflammatory Cell Recruitment in Biofilm Cell-Infected Mice Receiving Antifungal Chemotherapy.

J Clin Med 2019 Jan 26;8(2). Epub 2019 Jan 26.

LIBRO ⁻ 'Laboratório de Investigação em Biofilmes Rosário Oliveira', Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.

(1) Background: Due to a high rate of antifungal resistance, is one of the most prevalent spp. linked to systemic candidiasis, which is particularly critical in catheterized patients. The goal of this work was to simulate a systemic infection exclusively derived from biofilm cells and to evaluate the effectiveness of the treatment of two echinocandins-caspofungin (Csf) and micafungin (Mcf). Read More

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http://dx.doi.org/10.3390/jcm8020142DOI Listing
January 2019
1 Read

Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model.

FEMS Yeast Res 2019 Jan 24. Epub 2019 Jan 24.

Centro de Referencia para Lactobacilos (CERELA)-CONICET. Chacabuco 145. 4000. San Miguel de Tucumán. Tucumán. Argentina.

Vulvovaginal candidiasis (VVC) is one of the most frequent infections affecting women worldwide. Healthy vaginal microbiota is dominated by lactobacilli, which form a strong defense line against pathogens. In this work, in vitro antimicrobial properties of thirty vaginal Lactobacillus strains were evaluated against eleven Candida vaginal clinical isolates, employing three different methods. Read More

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http://dx.doi.org/10.1093/femsyr/foz008DOI Listing
January 2019

Bioimmunological activities of Candida glabrata cellular mannan.

FEMS Yeast Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Clinical Immunology and Allergy, Oncology Institute of St. Elisabeth, Bratislava, Slovakia.

Candida glabrata is a second most common human opportunistic pathogen which causes superficial but also life-threatening systemic candidiasis. According to the localization of mannans and mannoproteins in the outermost layer of the cell wall, mannan detection could be one of the first steps in the cell recognition of Candida cells by the host innate immune system. Mannans from the cell wall provide important immunomodulatory activities, compromising stimulation of cytokine production, induction of dendritic cells maturation and T-cell immunity. Read More

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http://dx.doi.org/10.1093/femsyr/foz009DOI Listing
January 2019
1 Read

Anti-Candidaalbicans germ tube antibodies reduce in vitro growth and biofilm formation of C. albicans.

Rev Iberoam Micol 2019 Jan 24. Epub 2019 Jan 24.

Department of Nursing I, University of the Basque Country UPV/EHU, Leioa, Spain. Electronic address:

Background: Invasive candidiasis by Candida albicans is associated with high morbidity and mortality, due in part to the late implementation of an appropriate antifungal therapy hindered by the lack of an early diagnosis.

Aims: We aimed to evaluate the in vitro antifungal activity of the antibodies against C. albicans germ tubes (CAGTA) raised in a rabbit model of candidemia. Read More

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http://dx.doi.org/10.1016/j.riam.2018.07.005DOI Listing
January 2019

Accuracy of the BD MAX™ vaginal panel in the diagnosis of infectious vaginitis.

Eur J Clin Microbiol Infect Dis 2019 Jan 26. Epub 2019 Jan 26.

Servicio de Microbiología, Hospital Universitario de Álava, Instituto de Investigación Biosanitaria, BioAraba, Osakidetza-Servicio Vasco de Salud. c/ Francisco Leandro de Viana, s/n., 01009, Vitoria-Gasteiz, Álava, Spain.

The aim of this study was to evaluate the BD MAX™ vaginal panel in the diagnosis of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis by comparing it with conventional methods: (i) combination of Hay criteria and presence of clue cells with predominant growth of Gardnerella vaginalis, (ii) yeast culture, and (iii) combination of culture, wet mount microscopic examination, and an alternative molecular assay. One thousand vaginal samples of women ≥ 14 years were analyzed; 5% of the samples belonged to pregnant women. 19. Read More

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http://dx.doi.org/10.1007/s10096-019-03480-8DOI Listing
January 2019
2 Reads

[Results of the use of micafungin in newborns].

Mikrobiyol Bul 2019 Jan;53(1):70-80

Uludag University Faculty of Medicine, Department of Pediatric Infectious Disease, Bursa, Turkey.

Invasive candidiasis is a common and serious infection in premature newborns. Preventing and treating fungal infections is very important to improve the prognosis of premature infants. Fluconazole and amphotericin B are used as the first choice in the treatment of invasive fungal infections of the newborns. Read More

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http://dx.doi.org/10.5578/mb.67599DOI Listing
January 2019
3 Reads

Evaluation of dental students' knowledge and patient care towards HIV/AIDS individuals.

Eur J Dent Educ 2019 Jan 25. Epub 2019 Jan 25.

School of Dentistry, University of Grande Rio (UNIGRANRIO), Duque de Caxias, Brazil.

Purpose: The aim was to evaluate the knowledge of the students of dental students regarding patients care towards HIV positive individuals.

Methods: Two hundred and eighty-three dental students (pre-clinical, n = 45; clinical, n = 238) answered an electronic questionnaire, approaching biosafety procedures, oral manifestations of AIDS and knowledge of HIV infection. Data were present as an average from findings from students of nine different semesters, grouping them by pre-clinical (1-4) and clinical (5-9) semesters, from two different university campuses. Read More

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http://dx.doi.org/10.1111/eje.12423DOI Listing
January 2019
10 Reads

Galectin-3 expression and effect of supplementation in neonatal mice with disseminated Candida albicans infection.

Pediatr Res 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, RI, USA.

Background: Invasive candidiasis is an important cause of fungal infections in immunocompromised patients, including premature infants. The S-type lectin, galectin-3 (gal3), is increasingly recognized for its role in antifungal host defense. This study tested the hypothesis that tissue gal3 expression is affected by disseminated infection with Candida albicans and that supplementation with gal3 will provide a benefit in this setting. Read More

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http://dx.doi.org/10.1038/s41390-019-0279-xDOI Listing
January 2019
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Invasive Candidiasis in Infants and Children: Recent Advances in Epidemiology, Diagnosis, and Treatment.

J Fungi (Basel) 2019 Jan 24;5(1). Epub 2019 Jan 24.

Infectious Diseases Section, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences and Hippokration General Hospital, 54642 Thessaloniki, Greece.

This paper reviews recent advances in three selected areas of pediatric invasive candidiasis: epidemiology, diagnosis, and treatment. Although the epidemiological trends of pediatric invasive candidiasis illustrate a declining incidence, this infection still carries a heavy burden of mortality and morbidity that warrants a high index of clinical suspicion, the need for rapid diagnostic systems, and the early initiation of antifungal therapy. The development of non-culture-based technologies, such as the T2Candida system and (1→3)-β-d-glucan detection assay, offers the potential for early laboratory detection of candidemia and CNS candidiasis, respectively. Read More

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http://www.mdpi.com/2309-608X/5/1/11
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http://dx.doi.org/10.3390/jof5010011DOI Listing
January 2019
9 Reads

Erosio interdigitalis blastomycetica: A review of interdigital candidiasis.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Veterans Affairs Medical Center Brooklyn, New York SUNY Downstate, Department of Dermatology, Brooklyn, New York.

Erosio interdigitalis blastomycetica (EIB) is a Candida infection affecting the third web space, between the third and fourth fingers. In 1915, Gougerot and Goncea first described saccharomycetic organisms isolated from the hands and feet. Johannes Fabry later named it in 1917, well before the genus Candida was introduced in 1923. Read More

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August 2018
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Alopecia areata in Tunisia: epidemio-clinical aspects and comorbid conditions. A prospective study of 204 cases.

Int J Dermatol 2019 Jan 24. Epub 2019 Jan 24.

Dermatology Department, Farhat Hached University Hospital, Sousse, Tunisia.

Background: Alopecia areata (AA) is an autoimmune condition that usually presents as patchy, nonscarring hair loss. Autoimmune disorders and atopy are reported as comorbid conditions. We aimed to investigate the demographics, clinical characteristics, and associations of AA in Tunisian patients. Read More

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http://dx.doi.org/10.1111/ijd.14381DOI Listing
January 2019
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Antifungal activity of oils macerates of North Sardinia plants against Candida species isolated from clinical patients with candidiasis.

Nat Prod Res 2019 Jan 24:1-5. Epub 2019 Jan 24.

a Department of Biomedical Sciences , University of Sassari , Sassari , Italy.

Antibiotic resistance is one of the bigger problem of public health: the rise of multi-drug resistant organisms causes a challenge in the treatment of infective diseases. Anti-Candida resistance to conventional antifungal agents has increased in the last period. Our research was intended to evaluate antimicrobial activity of oil macerate (OM) of Helichrysum microphyllum Cambess. Read More

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https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1
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http://dx.doi.org/10.1080/14786419.2018.1557175DOI Listing
January 2019
4 Reads

Ultrashort Self-Assembling Peptide Hydrogel for the Treatment of Fungal Infections.

Gels 2018 May 22;4(2). Epub 2018 May 22.

Biofunctional Nanomaterials Group, School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL Belfast, Northern Ireland.

The threat of antimicrobial resistance to society is compounded by a relative lack of new clinically effective licensed therapies reaching patients over the past three decades. This has been particularly problematic within antifungal drug development, leading to a rise in fungal infection rates and associated mortality. This paper highlights the potential of an ultrashort peptide, (naphthalene-2-ly)-acetyl-diphenylalanine-dilysine-OH (NapFFKK-OH), encompassing hydrogel-forming and antifungal properties within a single peptide motif, thus overcoming formulation (e. Read More

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http://www.mdpi.com/2310-2861/4/2/48
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http://dx.doi.org/10.3390/gels4020048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209295PMC
May 2018
6 Reads

Invasive fungal infections in critically ill patients: A prospective study from a tertiary care hospital in India.

Drug Discov Ther 2018 ;12(6):363-367

Department of Medicine, All India Institute of Medical Sciences.

Invasive fungal infections (IFI) are commonly seen in immunosuppressed individuals but their epidemiology in critically ill patients has not been well described. The aim of this study was to determine the frequency, risk factors and outcome of invasive fungal infections in a medical intensive care unit. A prospective observational study was carried out between August 2016 and March 2018 in the medical intensive care unit. Read More

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http://dx.doi.org/10.5582/ddt.2018.01068DOI Listing
January 2018
2 Reads

The role of autophagy in the pathogenesis of periodontal disease.

Oral Dis 2019 Jan 23. Epub 2019 Jan 23.

Department of Stomatology, Tongji Hospital of Tongji Medical College of Huazhong, University of Science and Technology, Wuhan, China.

Periodontal disease is a chronic inflammatory disease leading to destruction of periodontal tissues. As a local inflammation, periodontopathic bacterium, pro-inflammatory mediators, and local immune response play pivotal role in the progress of periodontal disease. Besides, cigarette smoke has long been associated with periodontal disease and tooth loss. Read More

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http://doi.wiley.com/10.1111/odi.13045
Publisher Site
http://dx.doi.org/10.1111/odi.13045DOI Listing
January 2019
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Vacuolar proton-translocating ATPase is required for antifungal resistance and virulence of Candida glabrata.

PLoS One 2019 23;14(1):e0210883. Epub 2019 Jan 23.

Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Vacuolar proton-translocating ATPase (V-ATPase) is located in fungal vacuolar membranes. It is involved in multiple cellular processes, including the maintenance of intracellular ion homeostasis by maintaining acidic pH within the cell. The importance of V-ATPase in virulence has been demonstrated in several pathogenic fungi, including Candida albicans. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210883PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343876PMC
January 2019
3 Reads

Prevalence of oral mucosal disorders during pregnancy: A systematic review and meta-analysis.

J Oral Pathol Med 2019 Jan 23. Epub 2019 Jan 23.

Brazilian Centre for Evidence-Based Research, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil.

Objective: To assess the prevalence of oral mucosal disorders during pregnancy.

Methods: Observational studies were selected by two reviewers in a two-phase process. Search strategies were applied at CINAHL, LILACS, LIVIVO, PubMed, Scopus, Web of Science, Google Scholar, OpenGrey, and ProQuest. Read More

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http://dx.doi.org/10.1111/jop.12831DOI Listing
January 2019
2 Reads