143,864 results match your criteria Cancers of the head & neck[Journal]


The clinical significance of Interleukin 24 and its potential molecular mechanism in laryngeal squamous cell carcinoma.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Department of Research, Guangxi Medical University Cancer Hospital, Guangxi, China.

Interleukin 24 (IL24) has been documented to be highly expressed in several cancers, but its role in laryngeal squamous cell carcinoma (LSCC) remains unclarified. In this study, to reveal the function and its clinical significance of IL24 in LSCC, multiple detecting methods were used comprehensively. IL24 protein expression was remarkably higher in LSCC (n= 49) than non-cancerous laryngeal controls (n= 26) as detected by in-house immunohistochemistry. Read More

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http://dx.doi.org/10.3233/CBM-201441DOI Listing

Prediction of inter-fractional radiotherapy dose plans with domain translation in spatiotemporal embeddings.

Med Image Anal 2020 May 17;64:101728. Epub 2020 May 17.

Polytechnique Montréal, Montréal, Québec, Canada; CHUM Research Center, Montréal, Québec, Canada. Electronic address:

External beam radiation therapy fractions have become extremely complex and tedious procedures to plan, due to stringent requirements of delivering the highest radiation dose to the tumor while maximally avoiding organs at risk. However, due to anatomic and/or biological changes between fractions, dose re-optimization may be needed. Re-optimization is a time-consuming task which is typically triggered based on subjective visual assessment by an experienced physician. Read More

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http://dx.doi.org/10.1016/j.media.2020.101728DOI Listing

FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway.

Mol Cell Endocrinol 2020 Jun 30:110925. Epub 2020 Jun 30.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. Electronic address:

Forkhead box N3 (FOXN3) is a subtype of FOX family that has been demonstrated to be implicated in several cancers. However, the role of FOXN3 in papillary thyroid carcinoma (PTC) and its mechanisms have not yet been investigated. Our results showed that FOXN3 was markedly down regulated in PTC tissues and cell lines. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110925DOI Listing

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

J Pathol 2020 Jul 3. Epub 2020 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, US.

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with squamous cell carcinomas display hyperactive NRF2 signaling, harboring activating mutations and copy number amplifications of the NFE2L2 oncogene or inactivating mutations or deletions of KEAP1 or CUL3, the proteins of which co-complex to ubiquitylate and degrade NRF2 protein. Read More

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http://dx.doi.org/10.1002/path.5504DOI Listing

Access to preventive care services and stage at diagnosis in head and neck cancer.

Head Neck 2020 Jul 3. Epub 2020 Jul 3.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: Decreased access to preventive care services has been proposed as a mechanism for the association between low socioeconomic status (SES) and advanced stage at diagnosis in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: Retrospective analysis of patients diagnosed with HNSCC in North Carolina between 2002 and 2006.

Results: A total of 1108 patients with HNSCC were included in the study. Read More

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http://dx.doi.org/10.1002/hed.26326DOI Listing

Risk of second primary cancers among survivors of gynecological cancers.

Gynecol Oncol 2020 Jun 29. Epub 2020 Jun 29.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 1201 11th Ave S, Birmingham, AL 35205, USA.

Objective: Survivors of gynecologic cancers have an increased risk of developing second primary cancers (SPC); however it is unclear which sites have higher risks. We aimed to ascertain risk of SPC among survivors of gynecological cancer, and identify anatomic sites at risk of SPC.

Methods: We queried the Surveillance, Epidemiology and End Results database (2000-2016) for confirmed cases of index gynecological (cervix uteri [cervical], corpus and uterus [endometrial], ovarian, vaginal, and vulvar) cancers. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.06.492DOI Listing

Extended role of transnasal oesophagoscopy: a review of the literature.

J Laryngol Otol 2020 Jun 18:1-6. Epub 2020 Jun 18.

ENT department, Lister Hospital, East and North Herts NHS Trust, Stevenage, UK.

Background: Advances in endoscopic technology have allowed transnasal oesophagoscopy to be used for a variety of diagnostic and therapeutic procedures.

Method: A review of the literature was carried out to look into the extended role of transnasal oesophagoscopy within otolaryngology, using the Embase, Cinahl and Medline databases.

Results: There were 16 studies showing that transnasal oesophagoscopy is safe and cost effective and can be used for removal of foreign bodies, tracheoesophageal puncture, laser laryngeal surgery and balloon dilatation. Read More

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http://dx.doi.org/10.1017/S002221512000105XDOI Listing

Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer.

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):227-236. Epub 2020 Jun 24.

Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.

Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called "C-cells"), via amino acid transporters. Amino acid transporters up-regulate in many cancers, and their expression level associate with clinical aggressiveness and prognosis. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.227DOI Listing

Targeted Oncogene Therapy Before Surgery in Pediatric Patients With Advanced Invasive Thyroid Cancer at Initial Presentation: Is It Time for a Paradigm Shift?

JAMA Otolaryngol Head Neck Surg 2020 Jul 2. Epub 2020 Jul 2.

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Importance: Initial data suggest the effectiveness of oncogene-specific targeted therapies in inducing tumor regression of diverse cancers in children and adults, with minimal adverse effects.

Observations: In this review, preliminary data suggest that systemic therapy may be effective in inducing tumor regression in pediatric patients with unresectable invasive thyroid cancer. Although most pediatric patients with thyroid cancer initially present with operable disease, some children have extensive disease that poses substantial surgical challenges and exposes them to higher than usual risk of operative complications. Read More

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http://dx.doi.org/10.1001/jamaoto.2020.1340DOI Listing

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.

Expert Rev Mol Med 2020 Jul 2;22:e3. Epub 2020 Jul 2.

Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 200 London Road, LiverpoolL3 9TA, UK.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with reported incidences of ~800 000 cases each year. One of the critical determinants in patient response to radiotherapy, particularly for oropharyngeal cancers, is human papillomavirus (HPV) status where HPV-positive patients display improved survival rates and outcomes particularly because of increased responsiveness to radiotherapy. The increased radiosensitivity of HPV-positive HNSCC has been largely linked with defects in the signalling and repair of DNA double-strand breaks. Read More

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http://dx.doi.org/10.1017/erm.2020.4DOI Listing

Mechanistic Models of Signaling Pathways Reveal the Drug Action Mechanisms behind Gender-Specific Gene Expression for Cancer Treatments.

Cells 2020 Jun 29;9(7). Epub 2020 Jun 29.

Clinical Bioinformatics Area. Fundación Progreso y Salud (FPS). CDCA, Hospital Virgen del Rocio, 41013 Sevilla, Spain.

Despite the existence of differences in gene expression across numerous genes between males and females having been known for a long time, these have been mostly ignored in many studies, including drug development and its therapeutic use. In fact, the consequences of such differences over the disease mechanisms or the drug action mechanisms are completely unknown. Here we applied mechanistic mathematical models of signaling activity to reveal the ultimate functional consequences that gender-specific gene expression activities have over cell functionality and fate. Read More

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http://dx.doi.org/10.3390/cells9071579DOI Listing

Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts.

Cancers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Oral cavity squamous cell carcinomas (OSCCs) are aggressive tumors, and their recurrence leads to poor prognosis and reduced survival rates. This study aimed to identify therapeutic targets and to evaluate the efficacy of targeted inhibitors in OSCC patient-derived xenograft (PDX) models. Herein, we reported that OSCC PDXs recapitulated the genomic signatures of their paired primary tumors and the expression of , , and was significantly upregulated in OSCC. Read More

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http://dx.doi.org/10.3390/cancers12071726DOI Listing

Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating miR-34a/RTCB Axis.

Nutrients 2020 Jun 29;12(7). Epub 2020 Jun 29.

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.

Genistein, a soy-derived phytoestrogen, has been shown to exhibit anti-neoplastic activities in various cancers. Nevertheless, its effects on the elimination of tumor-initiating cells of head and neck cancer (HNC-TICs) remain unclear. Here, we investigated the inhibitory effect of genistein on HNC-TICs and potential mechanisms. Read More

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http://dx.doi.org/10.3390/nu12071924DOI Listing

[Clinical diagnosis and treatment characteristics of pancreatic cystic neoplasms in pediatric patients: a report of 13 cases].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):525-529

Department of General Surgery, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430014, China.

To investigate the clinical characteristics of pancreatic cystic neoplasms in pediatric patients. The clinical data of 13 patients with pancreatic cystic neoplasm at Wuhan Children's Hospital from July 2007 to November 2019 were collected.There were 5 males and 8 females, with a mean age of 133 months(range: 9 to 170 months). Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20191122-00574DOI Listing

[Early experience of minimal invasive surgery for adolescent with pancreatic head tumor: a report of 15 cases].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):512-515

Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital, Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, China.

To summarize the characteristics and difficulties of minimal invasive surgery for adolescent with pancreatic head tumor. The data of adolescent younger than 28 years old with pancreatic head tumor treated at Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital from January 2014 to December 2019 were analyzed retrospectively. Fifteen cases were enrolled, included 5 males and 10 females. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20200211-00077DOI Listing

Increased Pain Reporting by Head and Neck Cancer Patients at Radiation Oncology Consultation: A Quality-of-Life Analysis.

Laryngoscope 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio, U.S.A.

Objectives: Head and neck cancers (HNC) are associated with significant morbidity. Quality-of-life (QoL) analyses can assist with understanding subjective factors shaping the patient experience. Here, we assess for patient and/or tumor factors associated with increased pain reporting at the time of initial radiation oncology consultation at a single institution in 2015. Read More

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http://dx.doi.org/10.1002/lary.28784DOI Listing

Sarcopenia and myosteatosis in patients undergoing curative radiotherapy for head and neck cancer: Impact on survival, treatment completion, hospital admission and cost.

J Hum Nutr Diet 2020 Jul 1. Epub 2020 Jul 1.

School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD, Australia.

Background: Computed tomography (CT) is the gold standard of body composition analysis at the tissue-organ level. The present study aimed to determine the impact of CT-defined sarcopenia and myosteatosis on outcomes, including overall survival, unplanned hospital admissions and related costs, in patients who had completed treatment of curative intent for head and neck cancer (HNC).

Methods: Retrospective observational study of patients undergoing radiotherapy of curative intent ± other treatment modalities for HNC. Read More

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http://dx.doi.org/10.1111/jhn.12788DOI Listing

Feasibility of Free Flap Reconstruction Following Salvage Robotic-Assisted Resection of Recurrent and Residual Oropharyngeal Cancer in 3 Patients.

Ear Nose Throat J 2020 Jul 1:145561320937627. Epub 2020 Jul 1.

Department of Otolaryngology, Head and Neck Surgery, Charing Cross Hospital, Imperial College Healthcare, London, United Kingdom.

Introduction: Human papilloma virus (HPV)-positive oropharyngeal cancer carries a good prognosis when managed with primary chemoradiotherapy. However, the dramatically increasing rate of this disease means more patients are now developing recurrence, with surgery remaining the mainstay of treatment. Despite this, there is no agreed technique for excision of recurrent oropharyngeal cancer. Read More

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http://dx.doi.org/10.1177/0145561320937627DOI Listing

CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway.

Cancer Manag Res 2020 23;12:4889-4898. Epub 2020 Jun 23.

Beijing YouAn Hospital, Capital Medical University, Beijing, People's Republic of China.

Background: Laryngeal carcinoma is a common cancer among head and neck tumors, accounting for 0.5-1% new cancer cases or deaths of all tumors throughout the body. Despite improvements in diagnostic and therapy, the prognosis of laryngeal carcinoma patients still remains poor. Read More

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http://dx.doi.org/10.2147/CMAR.S241620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320751PMC

Diagnostic Role of Dysregulated Circular RNA hsa_circ_0036722 in Laryngeal Squamous Cell Carcinoma.

Onco Targets Ther 2020 17;13:5709-5719. Epub 2020 Jun 17.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, People's Republic of China.

Purpose: Dysregulated circular RNAs (circRNAs) have been shown to play important roles in various cancers, and could serve as diagnostic biomarkers. However, research focusing on the roles of the circRNAs in laryngeal squamous cell carcinoma (LSCC) is limited. This research aimed to explore the expressions of hsa_circ_0036722 in LSCCs and its diagnostic significance. Read More

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http://dx.doi.org/10.2147/OTT.S231076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306465PMC

Middle ear adenomatous neuroendocrine tumors: suggestion for surgical strategy.

Braz J Otorhinolaryngol 2020 Jun 15. Epub 2020 Jun 15.

The Second Affiliated Hospital of Nanchang University, Department of Otolaryngology Head and Neck Surgery, Nanchang, China; Jiangxi Biomedical Engineering Research Center for Auditory Research, Nanchang, China. Electronic address:

Introduction: Middle ear adenomatous neuroendocrine tumors are extremely rare neoplasms with epithelial and neuroendocrine differentiation, accounting for fewer than 2% of all middle and inner ear tumors. Universal standard surgical procedures for different stages of these tumors remain elusive due to the limitation of the small number of case reports or investigations.

Objective(s): This study intends to investigate proper surgical strategies for patients with middle ear adenomatous neuroendocrine tumors. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.011DOI Listing

The impact of switching to mTOR inhibitor-based immunosuppression on long-term non-melanoma skin cancer incidence and renal function in kidney and liver transplant recipients.

Ren Fail 2020 Nov;42(1):607-612

Department of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Solid organ transplantation is associated with increased risk of non-melanoma skin cancer. Studies with short follow up times have suggested a reduced occurrence of these cancers in recipients treated with mammalian target of rapamycin inhibitors as maintenance immunosuppression. We aimed to describe the occurrence of skin cancers in renal and liver transplant recipients switched from calcineurin inhibitor to sirolimus-based regimes. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1785499DOI Listing
November 2020

Index of Cancer-Associated Fibroblasts Is Superior to the Epithelial-Mesenchymal Transition Score in Prognosis Prediction.

Cancers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan.

In many solid tumors, tissue of the mesenchymal subtype is frequently associated with epithelial-mesenchymal transition (EMT), strong stromal infiltration, and poor prognosis. Emerging evidence from tumor ecosystem studies has revealed that the two main components of tumor stroma, namely, infiltrated immune cells and cancer-associated fibroblasts (CAFs), also express certain typical EMT genes and are not distinguishable from intrinsic tumor EMT, where bulk tissue is concerned. Transcriptomic analysis of xenograft tissues provides a unique advantage in dissecting genes of tumor (human) or stroma (murine) origins. Read More

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http://dx.doi.org/10.3390/cancers12071718DOI Listing

The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner.

Cancers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

The treatment resistance of cancer cells is a multifaceted process in which DNA repair emerged as a potential therapeutic target. DNA repair is predominantly conducted by nuclear events; yet, how extra-nuclear cues impact the DNA damage response is largely unknown. Here, using a high-throughput RNAi-based screen in three-dimensionally-grown cell cultures of head and neck squamous cell carcinoma (HNSCC), we identified novel focal adhesion proteins controlling DNA repair, including the intermediate filament protein, synemin. Read More

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http://dx.doi.org/10.3390/cancers12071717DOI Listing

The Value of Laboratory Parameters for Anemia, Renal Function, Systemic Inflammation and Nutritional Status as Predictors for Outcome in Elderly Patients with Head-and-Neck Cancers.

Cancers (Basel) 2020 Jun 26;12(6). Epub 2020 Jun 26.

Department of Radiation Oncology, University of Freiburg-Medical Center, Robert-Koch-Str. 3, 79106 Freiburg, Germany.

The purpose of this study was to evaluate the value of routine blood markers regarding their predictive potential for treatment outcomes of elderly head-and-neck squamous cell carcinoma (HNSCC) patients. In total, 246 elderly HNSCC patients (≥65 years) undergoing (chemo)radiotherapy from 2010 to 2018 were analyzed for treatment outcomes, depending on their hemoglobin, glomerular filtration rate (GFR), C-reactive protein (CRP) and albumin values, representing anemia, kidney function, inflammation and nutrition status, respectively. Local/locoregional control, progression-free and overall survival (OS) were calculated using the Kaplan-Meier method. Read More

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http://dx.doi.org/10.3390/cancers12061698DOI Listing

A novel technique of arterial blood flow modification in intra-arterial chemoradiotherapy of maxillary sinus squamous cell carcinoma.

Oral Oncol 2020 Jun 27;109:104873. Epub 2020 Jun 27.

Department of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo 108-8329, Japan. Electronic address:

Objectives: Intra-arterial chemoradiotherapy via a superficial temporal artery is reportedly a useful organ-preserving treatment for maxillary sinus squamous cell carcinoma. This study aimed to determine whether blood flow modification facilitates sufficient drug delivery to the entire carcinoma via the maxillary artery alone, even for advanced tumors.

Materials And Methods: A retrospective study of 10 patients who were diagnosed with locally advanced carcinoma (4 [40%] at stage T3, 5 [50%] at T4a, and 1 [10%] at T4b) from August 2016 to July 2018, with tumor blood flow from both the maxillary and facial arteries, was conducted. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104873DOI Listing

An Update on Surgical Margins in the Head Neck Squamous Cell Carcinoma: Assessment, Clinical Outcome, and Future Directions.

Curr Oncol Rep 2020 Jun 30;22(8):82. Epub 2020 Jun 30.

Head and Neck Oncology Department, Tata Memorial Hospital and HBNI, Mumbai, India.

Purpose Of Review: Failure to achieve tumor-free margins is the single largest cause of death for head neck cancer patients. At the same time, it is the only factor that is in complete control of the surgeon. This review summarizes evidence for the definition, clinical implications, and methods to achieve optimal margins. Read More

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http://dx.doi.org/10.1007/s11912-020-00942-7DOI Listing

Multiclass cancer classification in fresh frozen and formalin-fixed paraffin-embedded tissue by DigiWest multiplex protein analysis.

Lab Invest 2020 Jun 29. Epub 2020 Jun 29.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Histomorphology and immunohistochemistry are the most common ways of cancer classification in routine cancer diagnostics, but often reach their limits in determining the organ origin in metastasis. These cancers of unknown primary, which are mostly adenocarcinomas or squamous cell carcinomas, therefore require more sophisticated methodologies of classification. Here, we report a multiplex protein profiling-based approach for the classification of fresh frozen and formalin-fixed paraffin-embedded (FFPE) cancer tissue samples using the digital western blot technique DigiWest. Read More

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http://dx.doi.org/10.1038/s41374-020-0455-yDOI Listing

MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.

BMC Cancer 2020 Jun 29;20(1):606. Epub 2020 Jun 29.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT antigens, melanoma-associated antigen A4 (MAGE-A4), New York oesophageal squamous cell carcinoma 1 (NY-ESO-1) and sarcoma antigen gene (SAGE).

Methods: MAGE-A4, NY-ESO-1 and/or SAGE antigen expression in tumour samples was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1186/s12885-020-07098-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325278PMC

Comparative Efficacy of First-Line Immune-Based Combination Therapies in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Department of Medical Oncology, Hôpital Européen Georges Pompidou, 75015 Paris, France.

Three drug combinations, ipilimumab-nivolumab (Ipi-Nivo), pembrolizumab-axitinib (Pembro-Axi), and avelumab-axitinib (Ave-Axi), have received regulatory approval in the USA and Europe for the treatment of metastatic renal cell carcinoma with clear cell component (mRCC). However, no head-to-head comparison data are available to identify the best option. Therefore, we aimed to compare these new treatments in a first-line setting. Read More

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http://dx.doi.org/10.3390/cancers12061673DOI Listing

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

: Cisplatin (CDDP) is commonly utilized in the treatment of advanced solid tumors including head and neck squamous cell carcinoma (HNSCC). Cisplatin response remains highly variable among individual tumors and development of cisplatin resistance is common. We hypothesized that development of cisplatin resistance is partially driven by metabolic reprogramming. Read More

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http://dx.doi.org/10.3390/cancers12061670DOI Listing

HCV infection and the risk of head and neck cancer: A meta-analysis.

Oral Oncol 2020 Jun 26;109:104869. Epub 2020 Jun 26.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy. Electronic address:

Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection and HNSCC. After screening citations from literature search, eight observational studies investigating the association between HCV and cancer(s) of either oral cavity, oropharynx, hypopharynx or larynx were included. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104869DOI Listing

Skull base chordomas review of current treatment paradigms.

World J Otorhinolaryngol Head Neck Surg 2020 Jun 18;6(2):125-131. Epub 2020 Apr 18.

Department of Otolaryngology- Head and Neck Surgery, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Chordomas are locally invasive neoplasms, arising from notochordal remnants and can appear anywhere along the axial skeleton. Local recurrences are common, and distant metastases may occur years after the initial presentation.

Methods: Literature review of current treatment strategies for chordomas of the skull base. Read More

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http://dx.doi.org/10.1016/j.wjorl.2020.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296475PMC

Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines.

Evid Based Complement Alternat Med 2020 26;2020:5867064. Epub 2020 May 26.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, China.

Background: Oral cancer belongs to the class of head and neck cancers and can be life threatening if not diagnosed and treated early. Activation of cell death via apoptosis or reactive oxygen species (ROS) accumulation and inhibition of cell cycle progression, migration, and epithelial-to-mesenchymal transition (EMT) may be a good strategy to arrest the development of oral cancer. In this study, we analyzed the possible action of chrysophanol isolated from the rhizomes of on the oral cancer cell lines FaDu (human pharynx squamous cell carcinoma) and SAS (human tongue squamous carcinoma) by investigating whether chrysophanol could influence cell death. Read More

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http://dx.doi.org/10.1155/2020/5867064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271060PMC

POSITIVE EXPRESSION OF NEDD9 IN HEAD AND NECK CANCER IS RELATED TO BETTER SURVIVAL PERIOD.

Acta Clin Croat 2019 Dec;58(4):655-661

1Division of Head and Neck Surgery, Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Otorhinolaryngology and Head and Neck Surgery, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Pathology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 4Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

The aim was to determine immunohistochemical expression of NEDD9 protein in head and neck squamous cell carcinoma (HNSCC) and the possible relation of its expression with primary tumor size (T), regional lymph node status (N), stage of disease (TNM) and survival period. A total of 131 patients with primary tumor localization in the area of oropharynx, hypopharynx and larynx, monitored for at least 5 years after initial surgical treatment were analyzed. The study included 128 male and three female patients, median age 62. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314307PMC
December 2019

Clinical PET/MR.

Authors:
Wolfgang Weber

Recent Results Cancer Res 2020 ;216:747-764

Department of Nuclear Medicine, School of Medicine, Technical University Munich, Ismaningerstr 22, 81675, Munich, Germany.

Oncologic imaging has been a major focus of clinical research on PET/MR over the last 10 years. Studies so far have shown that PET/MR with F-Fluorodeoxyglucose (FDG) overall provides a similar accuracy for tumor staging as FDG PET/CT. The effective radiation dose of whole-body FDG PET/MR is more than 50% lower than for FDG PET/CT, making PET/MR particularly attractive for imaging of children. Read More

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http://dx.doi.org/10.1007/978-3-030-42618-7_22DOI Listing
January 2020

Impact of stereotactic body radiation therapy on geriatric assessment and management for older patients with head and neck cancer using G8.

J Geriatr Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Radiation Medicine, Northwell Health, Lake Success, NY, USA. Electronic address:

Purpose: Management of head and neck cancers (HNC) in older adults is a common but challenging clinical scenario. We assess the impact of Stereotactic Body Radiation Therapy (SBRT) on survival utilizing the Geriatric-8 (G8) questionnaire.

Materials And Methods: 171 HNC patients, deemed medically unfit for definitive treatment, were treated with SBRT ± systemic therapy. Read More

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http://dx.doi.org/10.1016/j.jgo.2020.06.023DOI Listing

RTKs in pathobiology of head and neck cancers.

Adv Cancer Res 2020 15;147:319-373. Epub 2020 Jun 15.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.

Non-communicable diseases contribute to 71% of the deaths worldwide, of which cancers rank second after cardiovascular diseases. Among all the cancers, head and neck cancers (HNC) are consequential in augmenting the global cancer incidence as well as mortality. Receptor tyrosine kinases (RTKs) are emphatic for the matter that they serve as biomarkers aiding the analysis of tumor progression and metastasis as well as diagnosis, prognosis and therapeutic progression in the patients. Read More

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http://dx.doi.org/10.1016/bs.acr.2020.04.008DOI Listing

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1637-1644. Epub 2020 Jun 1.

Department of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.

Background/aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1637DOI Listing

Human Tissue Kallikreins in Polymorphous Adenocarcinoma: A Polymerase Chain Reaction and Immunohistochemical Study.

Head Neck Pathol 2020 Jun 26. Epub 2020 Jun 26.

Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Polymorphous adenocarcinoma (PAC) is the second most common malignant salivary gland tumour of minor salivary glands. Human tissue kallikreins (KLKs) are a family of highly conserved serine proteases expressed by various tissues and organs. The literature demonstrates a link between KLKs and salivary gland neoplasms. Read More

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http://dx.doi.org/10.1007/s12105-020-01196-2DOI Listing

What is the impact of COVID-19 on head and neck squamous cell carcinoma patients?

Authors:
Sean Dolan

Evid Based Dent 2020 06;21(2):52-53

DCT2, Oral and Maxillofacial Surgery, Ninewells Hospital, Dundee, UK.

Data sources It is not made clear in this review the different databases selected or how they conducted their search. The studies used are from 1975-2020Study selection The authors have performed a scoping review using 84 studies ranging from 1975-2020. The majority of these are from before the 2019-2020 COVID-19 outbreak period. Read More

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http://dx.doi.org/10.1038/s41432-020-0091-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317258PMC

Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery.

Nat Commun 2020 Jun 26;11(1):3257. Epub 2020 Jun 26.

Departments of Surgery, Nuclear Medicine and Molecular Imaging, Medical Imaging Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences between cancer and normal tissues for clinical use has been challenging. Here we describe the clinical translation of ONM-100, a nanoparticle-based fluorescent imaging agent. This is comprised of an ultra-pH sensitive amphiphilic polymer, conjugated with indocyanine green, which rapidly and irreversibly dissociates to fluoresce in the acidic extracellular tumor microenvironment due to the mechanism of nanoscale macromolecular cooperativity. Read More

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http://dx.doi.org/10.1038/s41467-020-16814-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320194PMC

Phase 1 clinical study of cell therapy with effective-mononuclear cells (E-MNC) for radiogenic xerostomia (first-in-human study) (FIH study on E-MNC therapy for radiogenic xerostomia).

Medicine (Baltimore) 2020 Jun;99(26):e20788

Department of Regenerative Oral Surgery, Unit of Translational Medicine.

Background: Treatment for most patients with head and neck cancers includes ionizing radiation with or without chemotherapy. This treatment causes irreversible damage to salivary glands in the irradiation field accompanied by a loss of fluid-secreting acinar cells and a considerable decrease of saliva secretion. There is currently no adequate conventional treatment for this condition. Read More

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http://dx.doi.org/10.1097/MD.0000000000020788DOI Listing

Comprehensive multiparameter genetic analysis improves circulating tumor DNA detection in head and neck cancer patients.

Oral Oncol 2020 Jun 23;109:104852. Epub 2020 Jun 23.

Department of Otolaryngology - Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, the Netherlands. Electronic address:

Introduction: Tumor-specific genetic aberrations in cell-free DNA (cfDNA) from plasma are promising biomarkers for diagnosis of recurrent head and neck squamous cell carcinoma (HNSCC). However, the sensitivity when using somatic mutations only in cfDNA is suboptimal. Here, we combined detection of copy number aberrations (CNAs), human papillomavirus (HPV) DNA and somatic mutations in a single sequencing workflow. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104852DOI Listing

Characteristics of Participation in Patient-Reported Outcomes and Electronic Data Capture Components of NRG Oncology Clinical Trials.

Int J Radiat Oncol Biol Phys 2020 Jun 23. Epub 2020 Jun 23.

Emory University Hospital/Winship Cancer Institute.

Purpose: To assess reasons patients do not consent to patient-report outcome (PRO) and electronic PRO data capture components of clinical trials and potential selection bias by having a separate consent.

Methods: Selected XXXX trials were included based on disease site and inclusion of PROs and electronic PRO data capture via VisionTree Optimal Care (VTOC; VisionTree Software, Inc, San Diego, CA), as separate consent questions. Reasons for not participating were assessed. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.030DOI Listing

Adapting Head and Neck Cancer Management in the Time of COVID-19.

Int J Radiat Oncol Biol Phys 2020 07 18;107(4):628-630. Epub 2020 Apr 18.

University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.ijrobp.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165274PMC

Pretreatment High MCV as Adverse Prognostic Marker in Nonanemic Patients with Head and Neck Cancer.

Laryngoscope 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy.

Objective: Mean corpuscular volume (MCV) has been shown in to be a reliable prognostic marker in other cancers; however, no evidence exists on its use in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the association between MCV, hemoglobin, platelet count and albumin concentration, and survival in stage III/IVA-B HNSCC treated with concurrent chemoradiotherapy.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1002/lary.28882DOI Listing

A retrospective study on the prognostic value of preoperative C-reactive protein to albumin ratio in patients with oral cavity squamous cell carcinoma.

PeerJ 2020 16;8:e9361. Epub 2020 Jun 16.

Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: Although the C-reactive protein-to-albumin ratio (CAR) can predict poor outcomes in assorted cancers, its prognostic value in oral cavity squamous cell carcinoma (OSCC) remains unclear. We explored the value of preoperative CAR in predicting clinical outcomes in OSCC patients treated with radical surgery.

Methods: All the recommended cutoff values were defined analyzing receiver operating characteristic curves or overall survival (OS). Read More

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http://dx.doi.org/10.7717/peerj.9361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304427PMC

Impact of SRY-Box Transcription Factor 11 Gene Polymorphisms on Oral Cancer Risk and Clinicopathologic Characteristics.

Int J Mol Sci 2020 Jun 23;21(12). Epub 2020 Jun 23.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Oral cancer is among the most common cancers worldwide and has become a major global health problem because of its relatively high morbidity and mortality rates. The sex-determining region on the Y-chromosome-related high-mobility-group box (SOX) transcription factor 11 (SOX11) plays a key role in human development and differentiation and is frequently increased in various human cancers. However, the clinical significance of SOX11 polymorphisms in oral cancer and their association with oral cancer risk are unclear. Read More

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http://dx.doi.org/10.3390/ijms21124468DOI Listing

Detection of Human papillomavirus and the role of p16INK4a in colorectal carcinomas.

PLoS One 2020 25;15(6):e0235065. Epub 2020 Jun 25.

Universidade Federal de Goiás (UFG), Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Faculdade de Medicina (FM) e Instituto de Patologia Tropical e Saúde Pública (IPTSP), Goiânia, GO, Brasil.

Introduction: Human papillomavirus (HPV) infection is associated with the development of anogenital and head and neck cancers. In recent years a potential role of HPV in colorectal cancer (CRC) has been suggested.

Objective: To investigate the presence of HPV in colorectal carcinomas and to study the role of p16INK4a as a marker of transcriptionally active HPV infection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316293PMC