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    11282 results match your criteria Cancers of the Oral Mucosa

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    Cannabidiol: an alternative therapeutic agent for oral mucositis?
    J Clin Pharm Ther 2017 Feb 12. Epub 2017 Feb 12.
    Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    What Is Known And Objective: Chemo- and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as well, resulting in adverse effects. Oral mucositis is especially of concern, due to the morbidity that it causes. Read More

    [Cancer and mycoses and literature review].
    Bull Soc Pathol Exot 2017 Feb 11. Epub 2017 Feb 11.
    Service de parasitologie-mycologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.
    Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Read More

    Thioredoxin and metallothionein: Homeostasis-related proteins in lip carcinogenesis.
    Arch Oral Biol 2017 Feb 1;77:75-81. Epub 2017 Feb 1.
    Universidade Federal de Minas Gerais, School of Dentistry, Department of Oral Surgery and Pathology, Av. Antônio Carlos 6627, Pampulha, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
    Objective: Thioredoxin (Trx) and metallothionein (MT) are involved in the development of some carcinomas; however, the role of these proteins in labial carcinogenesis has not yet been tested. The aims of the study were to evaluate and to correlate the immunoexpression of Trx and MT in actinic cheilitis, lip squamous cell carcinoma, and normal vermillion lip mucosa.

    Design: Immunohistochemistry was undertaken for Trx and MT in samples of actinic cheilitis, lip squamous cell carcinoma, and normal lip mucosa. Read More

    Osteolipoma of the buccal mucosa: A case report.
    Aust Dent J 2017 Feb 6. Epub 2017 Feb 6.
    Department of Oral Diagnostic and Surgical Sciences, School of Dentistry, University of Otago, Dunedin, New Zealand.
    Lipomas are benign mesenchymal neoplasms of soft tissue that can be found commonly in any part of the human body. Their presence in the oral mucosa is uncommon however, with approximately 4% of the cases occurring in the oral cavity(1) . Oral lipomas are likely to have originated from mature adipose tissue and there are several histological variants of lipomas described, which are identified according to the predominant type of tissue in addition to adipose tissue. Read More

    Mutational Status of NRAS and BRAF Genes and Protein Expression Analysis in a Series of Primary Oral Mucosal Melanoma.
    Am J Dermatopathol 2017 Feb;39(2):104-110
    *Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil; †Department of Dermatology, School of Medicine, University of São Paulo, São Paulo, Brazil; ‡Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil; and §Department of Pathology, Obrero Hospital, La Paz, Bolivia.
    Primary oral mucosal melanoma is an extremely rare and aggressive tumor arising from melanocytes located in the mucosal epithelium of the oral cavity. Although malignant melanoma of oral mucosa shares some clinical features with its cutaneous counterpart, it has been associated with a worst prognosis; its etiopathogenesis are still only partially unraveled as there is no influence of UV radiation. It is known that the mitogen-activated protein kinase pathway mediates cellular responses to growth signals and its activation is an important phenomenon in melanoma. Read More

    Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients.
    Ann Otol Rhinol Laryngol 2017 Jan 1:3489416688478. Epub 2017 Jan 1.
    4 New York Center for Voice and Swallowing Disorders, New York, New York, USA.
    Objective: Metformin is an oral anti-hyperglycemic agent used to treat type 2 diabetes mellitus (DM). In vitro and animal models have shown that metformin can prevent the progression of oral lesions to carcinoma; however, there is conflicting data in the clinical literature regarding risk reduction for malignancy in head and neck cancer (HNC).

    Study Design: Case series. Read More

    Nevus Spilus (Speckled Lentiginous Nevus) in the Oral Cavity: Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 Jan;39(1):e8-e12
    *Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD; and †Department of Pathology, Walter Reed National Medical Military Center, Bethesda, MD.
    The congenital melanocytic nevus is a pigmented melanocytic lesion that presents at birth or shortly thereafter. It is commonly described on the skin, usually on the trunk and extremities. Only five intraoral cases of congenital melanocytic nevi have been described in the English literature. Read More

    Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision.
    Recent Pat Inflamm Allergy Drug Discov 2016 Dec 26. Epub 2016 Dec 26.
    Department of Biochemistry & Genetics, Barkatullah University, Bhopal-462 026, Madhya Pradesh, India.
    Background: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Read More

    Bioavailability of aspirin in rats comparing the drug's uptake into gastrointestinal tissue and vascular and lymphatic systems: implications on aspirin's chemopreventive action.
    J Physiol Pharmacol 2016 Oct;67(5):635-642
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston - McGovern Medical School, Houston, TX, USA.
    Aspirin is an effective analgesic and antiplatelet drug that in addition to its ability to reduce pain, inflammation and fever, appears to have efficacy in the prevention/treatment of a range of diseases including heart disease, numerous cancers and Alzheimer's. It is important to understand the bioavailability of aspirin and its major metabolite, salicylic acid, since dosage and route of administration can vary for treating differing diseases, and the major side-effects of aspirin, upper gastrointestinal ulceration and bleeding, are dose-dependent. We examined the time course for gastroduodenal uptake of aspirin and the appearance of its major metabolite salicylic acid in blood and lymph after intragastric (to simulate oral) and intraduodenal (to simulate enteric-coating) dosing in rats. Read More

    Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma.
    Contemp Clin Dent 2016 Oct-Dec;7(4):524-528
    Department of Oral Pathology, Malabar Dental College, Vattamkulam, Kerala, India.
    Context: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located on chromosome 10q23. PTEN has its major function in the regulation of cell adhesion, cell cycle arrest, migration, apoptosis programming, and differentiation. This genomic region suffers loss of heterozygosity in many human cancers. Read More

    microRNA from brush biopsy to characterize oral squamous cell carcinoma epithelium.
    Cancer Med 2017 Jan 18;6(1):67-78. Epub 2016 Dec 18.
    Department of Oral Medicine and Oral Diagnostics, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois, 60610.
    Few cancers are diagnosed based on RNA expression signatures. Oral squamous cell carcinoma (OSCC) is no exception; it is currently diagnosed by scalpel biopsy followed by histopathology. This study sought to identify oral tumor epithelial microRNA (miRNA) expression changes to determine if these changes could be used to diagnose the disease noninvasively. Read More

    Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma.
    Cochrane Database Syst Rev 2016 12 11;12:CD010963. Epub 2016 Dec 11.
    Head and Neck Unit, Royal Marsden Hospital, Fulham Road, London, UK, SW3 6JJ.
    Background: More than 400,000 cases of oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed each year worldwide and the incidence is rising, partly as a result of human papillomavirus. Human papillomavirus-associated OPSCC affects younger patients and often presents at a higher stage; however, it is associated with a better prognosis.Until recently, first-line management of OPSCC involved chemoradiotherapy, as research had demonstrated comparable survival outcomes when compared with open surgery, with significantly decreased morbidity. Read More

    On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa.
    Oral Dis 2016 Nov 29. Epub 2016 Nov 29.
    Biomodels, LLC, Watertown, MA, USA.
    Objective: mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor-associated stomatitis (mIAS) a common, significant, dose-limiting toxicity, with aphthous-like lesions. Our objective was to assess the utility of a new organotypic model in defining mIAS' pathogenesis.

    Materials And Methods: The effect of everolimus on organotypic human oral mucosa was studied. Read More

    Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study.
    Diagn Pathol 2016 Nov 21;11(1):134. Epub 2016 Nov 21.
    Department of Pathology, University of Medicine and Pharmacy Craiova, Petru Rares 2, Craiova, 200349, Romania.
    Background: Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT with maxillary sinus extension and the second one that also involves the buccal vestibule mucosa with peculiar histopathological and immunohistochemical data.

    Case Presentation: Here we report the case of a 45-year-old female with a CEOT diagnosed and treated at the Oral & Maxillofacial Surgery Department, County Clinical Emergency Hospital of Craiova, Romania. Read More

    Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer.
    Oral Oncol 2016 Nov 6;62:34-43. Epub 2016 Oct 6.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:
    Objectives: This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence.

    Materials And Methods: Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral precancer patients, and 95 oral squamous cell carcinoma patients. Read More

    May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?
    Pathol Oncol Res 2017 Jan 16;23(1):197-206. Epub 2016 Nov 16.
    Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal, 576104, India.
    Matrix metalloproteinases-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), may presumably have an important role on the invasion and metastatic spread of malignancies attributed to an uncontrolled degradation of the extracellular matrix (ECM). A retrospective chart analysis was carried out to study the expression of MMP-2 and TIMP-2 on the archival samples of oral squamous cell carcinoma (OSCC) (n = 30) and normal mucosa (n = 10) by immunohistochemistry and compared with the clinicopathologic parameters of cases. Both MMP-2 and TIMP-2 expressions showed a positive correlation with the grades, stages and metastatic capacities of tumors (Spearman's correlation, p < 0. Read More

    Lipoma of the cheek presenting with recurrent sialadenitis of the right parotid gland: a case report.
    J Med Case Rep 2016 Nov 3;10(1):311. Epub 2016 Nov 3.
    Department of Oral and Maxillofacial Surgery, Oral Pathology/Medicine and Oral Radiology, University of Nairobi Dental Hospital, P.O. Box 19676-00202, Nairobi, Kenya.
    Background: Lipomas are benign neoplasms arising from adipose tissue. Oral lipomas have been reported in the buccal mucosa, tongue, floor of the mouth and lips; however, the case of a lipoma occurring as an antecedent lesion to recurrent sialadenitis is hitherto unreported in the English literature.

    Case Presentation: We report the case of an intraoral lipoma occurring with signs and symptoms of recurrent sialadenitis in a 15-year-old Kenyan girl of Kikuyu descent. Read More

    Immunoexpression of Epithelial Mesenchymal Transition Proteins E-Cadherin, β-Catenin, and N-Cadherin in Oral Squamous Cell Carcinoma.
    Int J Surg Pathol 2016 Dec 15;24(8):696-703. Epub 2016 Jun 15.
    KLE University's JN Medical College, Belgaum, Karnataka, India.
    Aims Epithelial mesenchymal transition (EMT) is a crucial process for acquisition of malignant phenotype, aggressiveness, and metastatic capacity in neoplasms. It is characterized by loss of epithelial markers and gain of mesenchymal markers. Studies on EMT and its potential association with the histological grading are sparse in oral squamous cell carcinoma (OSCC). Read More

    Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis.
    Clin Cancer Res 2016 Nov 21;22(22):5574-5581. Epub 2016 Oct 21.
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
    Purpose: Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits the oral cavity. It causes periodontal disease and has also been implicated in the development of human cancers. Read More

    Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma.
    Head Neck Pathol 2016 Dec 27;10(4):501-508. Epub 2016 May 27.
    Department of Pathology, University of Virginia, Charlottesville, VA, USA.
    Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52. Read More

    Histologic and immunohistochemical evaluation of mirror image biopsies in oral squamous cell carcinoma.
    J Oral Biol Craniofac Res 2016 Sep-Dec;6(3):194-197. Epub 2016 Jun 29.
    Department Oral Pathology and Microbiology, Saveetha Dental College, Chennai, Tamil Nadu, India.
    Background And Objective: The concept of field cancerization has frequently been quoted to explain the occurrence of multiple primary cancers in the head and neck region and recurrence following complete excision of the original tumor. The main objective is to study the occurrence of field changes in mirror image biopsy in relation to histopathological changes in the oral mucosa among oral cancer patients using hematoxylin and eosin and to study the expression pattern of cytokeratin, Ki-67 and p53 in oral squamous cell carcinoma and mirror image biopsy.

    Materials And Methods: A pilot study of 15 patients clinically diagnosed with carcinoma lesion and their corresponding mirror image sites were taken and stained using immunohistochemistry method for the expression of cytokeratin, Ki-67 and p53. Read More

    [Oral health of users of psychoactive substances].
    Presse Med 2016 Dec 10;45(12 Pt 1):1178-1186. Epub 2016 Oct 10.
    Conseil général du Val-de-Marne, service de santé publique dentaire, 94000 Créteil, France; CMS d'Ivry, service dentaire, 94200 Ivry-sur-Seine, France; ASPBD, secrétariat général, 75019 Paris, France. Electronic address:
    This article reminds you that, whatever the psychoactive substance in question, it is not one that has repercussions on the oral health of its user. This affects both the tooth, the periodontal and oral mucosa. Drug addicts, especially those engaged in polydrug use, represent the population at the largest risk for oral cancer. Read More

    Argyrophilic nuclear organizer region and p73 expression in head and neck squamous cell carcinomas: Teammates or adversaries?
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):427-435
    Department of Pathology, Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan, Malaysia.
    Context: Head and neck squamous cell carcinoma (HNSCC) consists of squamous cell carcinomas (SCCs) arising in the upper aerodigestive tract and accounts for 5% of cancers worldwide. In Malaysia, cancers of the nasopharynx, larynx, tongue and oral cavity are among the top twenty most common cancers in men. Argyrophilic nuclear organizer regions (AgNORs) are increased from normal mucosa to premalignant lesions to malignant lesions and have been associated with tumor grade and prognosis of patients. Read More

    Multinucleate cell angiohistiocytoma of the lower vermilion lip: an unusual site.
    G Ital Dermatol Venereol 2016 Oct 5. Epub 2016 Oct 5.
    DISSAL, Department of Dermatology, IRCCS-AOU S. Martino-IST, University of Genoa,Genoa, Italy -
    Multinucleate cell angiohistiocytoma (MCA) represent an uncommon benign fibrohistiocytic vascular lesion that sometimes may go undiagnosed because of its clinical and hystopathological similarities with benign fibrous histiocytoma and other soft-tissue neoplasms especially when localized on oral cavity or semi mucosa. We report the case of a solitary multinucleate cell angiohistiocytoma on the lower lip of a 46-year old woman suggesting that this rare lesion should be considered in the differential diagnosis of the oral soft-tissue neoplasms. Read More

    HPV in Head and Neck Cancer-30 Years of History.
    Recent Results Cancer Res 2017;206:3-25
    Department of Clinical Research, Biohit Oyj, Helsinki, Finland.
    The interesting history of papillomavirus (PV) research has been reviewed before. The history of human papillomavirus (HPV) in head and neck region starts in 1901 when the contagious transmission of warty lesions into the mouth via oral sex was described, although the confirmation of their viral etiology had to wait until 1907. Ullman was the first to associate the human wart virus with laryngeal warts. Read More

    A comparative analysis of oral and maxillofacial pathology over a 16-year period, in the north of Portugal.
    Int Dent J 2017 Feb 29;67(1):38-45. Epub 2016 Sep 29.
    Molecular Pathology and Immunology Department, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
    Objectives: To determine the frequency and spectrum of oral and maxillofacial lesions biopsied in a hospital population in the northern region of Portugal.

    Methods: We conducted descriptive analyses of pathology reports from biopsies of oral and maxillofacial lesions performed between 1990 and 2006, in Oporto Hospital Center. Information on gender and age of patient, location of the lesions and the histopathological diagnosis were analysed. Read More

    IL-1β maintains the redox balance by regulating glutaredoxin 1 expression during oral carcinogenesis.
    J Oral Pathol Med 2016 Sep 22. Epub 2016 Sep 22.
    Department of Oral Medicine, Hospital of Stomatology, Guangzhou, Guangdong, China.
    Background: Interleukin-1 beta (IL-1β) is a pleiotropic cancer-inflammation-linked cytokine which has been reported upregulated in many cancers. In our previous study, IL-1β was found to be one of the key node genes during oral malignant transformation, and glutaredoxin 1 (Grx1) was identified as one of the downstream genes of IL-1β in tumor microenvironment. Grx1 is ubiquitous oxidoreductase which is necessary for scavenging reactive oxygen species (ROS) and the intracellular redox balance maintenance. Read More

    Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma.
    J Clin Diagn Res 2016 Aug 1;10(8):ZC100-3. Epub 2016 Aug 1.
    Professor and Head, Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra University , Porur, Chennai, India .
    Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder. Among the cell types in the stroma, mast cells play an important role in tumourigenesis through various mechanisms.

    Aim: The present study was aimed at comparing the mast cell count among normal oral mucosa, leukoplakia and Oral squamous cell carcinoma (OSSC) and to evaluate the possible role of mast cells in carcinogenesis. Read More

    Abnormal Nuclear Variations in Response to Radiotherapy- As a Tool in Treatment Planning and Assessment of Prognosis.
    J Clin Diagn Res 2016 Aug 1;10(8):AC08-12. Epub 2016 Aug 1.
    Consultant, Paediatrics, Govt. Hospital , Rishikesh, Uttarakhand, India .
    Introduction: The treatment approaches for oral squamous cell carcinoma (OSCC) include single management with surgery, radiotherapy, along with chemotherapy or various combinations of these modalities. The estimation of radio sensitivity of individual tumours is essential for planning the optimum radiation schedule for each patient. Assessment of radiation induced histo morphological changes in the nucleus is a known marker of radiosensitivity. Read More

    Betel quid chewing leads to the development of unique de novo malignancies in liver transplant recipients, a retrospective single center study in Taiwan.
    Medicine (Baltimore) 2016 Sep;95(37):e4901
    aDepartment of General Surgery, Keelung Chang Gung Memorial Hospital, Keelung City, Anle District bSchool of Medicine, Chang Gung University cDepartment of Liver and Transplantation Surgery, Linkou Chang Gung Memorial Hospital, Guishan District, Taoyuan City, Taiwan.
    Orthotopic liver transplantation (OLT) is the choice of treatment not only for end-stage liver disease and acute liver failure but also for hepatocellular carcinoma (HCC). The development of de novo malignancies after liver transplantation plays an important role in late mortality; the incidence of late mortality has increased owing to improved survival. The incidence of de novo malignancies is 2. Read More

    Relation Between Periodontal Status and Pre-Cancerous Condition (Oral Lichen Planus): A Pilot Study.
    Adv Clin Exp Med 2016 Jul-Aug;25(4):763-6
    Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia.
    Background: Oral lichen planus (OLP) is a common chronic mucocutaneous disease mostly seen in middle aged and elderly females. Oral lichen planus can occur in different oral sites such as gingiva, labial, buccal mucosa and on the tongue. And can have an indirect effect on initiating periodontitis. Read More

    Accuracy of diagnostic demarcation of undifferentiated-type early gastric cancer for magnifying endoscopy with narrow-band imaging: surgical cases.
    Surg Endosc 2016 Aug 29. Epub 2016 Aug 29.
    Department of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan.
    Background And Aim: The usefulness of magnifying endoscopy with narrow-band imaging (ME-NBI) in undifferentiated-type early gastric cancers (UD-type EGCs) is unclear. This study investigated the accuracy of ME-NBI in the diagnostic demarcation.

    Methods: Among UD-type EGCs that were initially surgically resected between June 2011 and August 2014 in this hospital, 74 lesions were studied that were preoperatively diagnosed with white-light imaging (WLI) or endoscopic ultrasonography as lesions for which endoscopic treatment was not indicated and found to be early gastric cancers by postoperative pathology. Read More

    Keratocystic odontogenic tumor overexpresses invadopodia-related proteins, suggesting invadopodia formation.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Oct 22;122(4):500-8. Epub 2016 Jun 22.
    Cell Culture Laboratory, Faculty of Dentistry, Federal University of Pará, Belém, Brazil.
    Objective: Keratocystic odontogenic tumor (KOT) is an odontogenic neoplasm that shows aggressive clinical behavior and local invasiveness. Invadopodia are actin-rich cellular protrusions exhibiting proteolytic pericellular activity, thereby inducing focal invasion in neoplastic cells and increasing neoplasms aggressiveness. Thus, this study aimed to evaluate immunoexpression of invadopodia-related proteins, cortactin, MT1-MMP, Tks4, and Tks5, in KOT. Read More

    Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis.
    Curr Oral Health Rep 2016 Jun 31;3(2):82-92. Epub 2016 Mar 31.
    Institute of Oral Health Research, University of Alabama at Birmingham School of Dentistry, Birmingham, AL 35294, USA.
    Several molecular pathways have been shown to play critical roles in the pathogenesis of odontogenic tumors. These neoplasms arise from the epithelial or mesenchymal cells of the dental apparatus in the jaw or oral mucosa. Next generation genomic sequencing has identified gene mutations or single nucleotide polymorphisms associated with many of these tumors. Read More

    Candida infection in oral leukoplakia: an unperceived public health problem.
    Acta Odontol Scand 2016 Oct 19;74(7):565-569. Epub 2016 Aug 19.
    a Department of Microbiology, Faculty of Medical Sciences , University of Sri Jayewardenepura, Gangodawila , Nugegoda , Sri Lanka.
    Objectives: The study aimed to determine the proportion, known risk factors and etiology for Candida infection in leukoplakia lesions among patients with oral leukoplakia attending the Oral and Maxillofacial Clinic at a Tertiary Care Hospital in Sri Lanka.

    Materials And Methods: Eighty clinically suspected oral leukoplakia patients were included. Two oral swabs each, from leukoplakia patients: one swab from the lesion and the other one from the contralateral unaffected corresponding area (as a control) were collected. Read More

    Ocular Onset of Paraneoplastic Pemphigus Presenting as Hyperemic Conjunctivitis and Massive Bilateral Eyelid Ulceration: A Case Report and Literature Review.
    Ocul Immunol Inflamm 2016 Aug 18:1-4. Epub 2016 Aug 18.
    a Department of Ophthalmology , Humanitas Clinical and Research Institute , Rozzano , Milan , Italy.
    Introduction: Paraneoplastic clinical signs are characterized by a large and heterogeneous variety of manifestations due to several possible underlying neoplasms. Paraneoplastic pemphigus (PNP) is a particular paraneoplastic variety that usually primarily affects the dermic and/or oral mucosa and is characterized by a high rate of mortality (90%). Therefore, it is important to recognize its possible signs early. Read More

    Gender specific association of TP53 polymorphisms (EX4 215G>C Arg72Pro, IVS3+40-41ins16, and IVS6+62G>A), with risk of oral cancer subtypes and overall survival of the patients.
    Mol Carcinog 2017 Mar 31;56(3):895-912. Epub 2016 Aug 31.
    Indo-American Cancer Research Foundation, Formerly Research and Development, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.
    Reports on the association of TP53 polymorphisms with oral cancer are not only limited but also not specific to site and/or gender. Hence, we examined the effect of TP53 polymorphisms (EX4 215G>C, IVS3+40-41ins16 and IVS6+62G>A) on buccal mucosa cancer (BMC) and tongue cancer (TC) risk, survival of patients in relation to risk and clinical factors, gender wise (excepting for estimating hazards ratio [HR]), using Fisher's Exact Test, Kaplan-Meier analysis, and Cox-proportional hazards models. The exonic polymorphism increased BMC and TC risk in males by 2-4-fold. Read More

    Detection of potentially malignant lesions and squamous cell carcinomas in consultation of surgical denstitry.
    Tunis Med 2016 Jan;94(1):29-33
    Unlabelled: Squamous cell carcinoma can occur on a apparently healthy mucosa or be preceded by lesions Chronic called potentially malignant, often asymptomatic, rarely showing the reason for consultation of patients, particularly in our Moroccan background which is  characterized by a care difficulty of access and the absence of priority to oral health.

    Objective: To assess the prevalence of diseases potentially and malignant squamous cell carcinomas, and the role of certain risk factors in the onset of these lesions.

    Methods: In the consultant population center Dental Consultation and Treatment of Casablanca CHU, we conducted a descriptive survey with 306 patients seen for different patterns between May and July 2010. Read More

    Distant Skin Metastases from Carcinoma Buccal Mucosa: A Rare Presentation.
    Indian J Dermatol 2016 Jul-Aug;61(4):468
    Department of Radiation Oncology, Max Super Speciality Hospital, Vaishali, Ghaziabad, Uttar Pradesh, India.
    Cancer of the oral cavity makes up approximately 30% of all head and neck region tumors. Skin metastasis is rare with an incidence ranging between 0.7% and 2. Read More

    Randomized DoubleBlind PlaceboControlled Trial of Propolis for Oral Mucositis in Patients Receiving Chemotherapy for Head and Neck Cancer.
    Asian Pac J Cancer Prev 2016 ;17(7):3611-4
    Department of Oral and Maxillofacial Diseases Diagnosis, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Email :
    Background: Propolis based preparations have a wide range of applications in various specialties of dentistry. The aim of this clinical trial was to test the efficacy of propolis as a mouthwash in the reduction of chemotherapy induced oral mucositis (OM) in a single center.

    Materials And Methods: In this randomised, controlled study patients undergoing chemotherapy were included consecutively and randomised to an experimental group receiving propolis mouthwash (n = 20) and a control group receiving diluted water (n=20). Read More

    Comparing Survival of Oral Cancer Patients Before and After Launching of the Universal Coverage Scheme in Thailand.
    Asian Pac J Cancer Prev 2016 ;17(7):3541-4
    Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand Email :
    Background: As the treatment modalities for oral cancer have been relatively consistent during the last two decades, this study was conducted to compare survivals of oral cancer patients in Khon Kaen Province before and after the universal coverage scheme (UC) was launched in Thailand.

    Materials And Methods: The data were retrieved from the populationbased cancer registry of Khon Kaen for oral cancer patients diagnosed during 19922001 (preUC), and 20042012 (postUC). To compare survival of the two cohorts, Kaplan Meier and log rank tests were employed. Read More

    Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma.
    Acta Biochim Pol 2016 5;63(3):505-9. Epub 2016 Aug 5.
    Department of Statistics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
    The aim of the study was to assess the expression of MGMT, p16, and APC genes in tumors and matching surgical margin samples from 56 patients with primary OSCC. We also analyzed the association of the clinical variables with the expression of the studied genes. After RNA isolation and cDNA synthesis gene expression levels were assessed by quantitative reverse transcription (qRT)-PCR. Read More

    Lipoma of mandibular buccal vestibule: a case with histopathological literature review.
    BMJ Case Rep 2016 Aug 3;2016. Epub 2016 Aug 3.
    Department of Basic Dental Sciences, Dental Anatomy & Oral Histology, College of Dentistry, Taif, Makkah, Saudi Arabia.
    Lipoma is a tumour of soft tissue with rare occurrence in oral cavity accounting for only 1-4% of benign oral tumours. Most common sites of involvement are the buccal mucosa, tongue and floor of the mouth with typical presentation of an asymptomatic, soft, smooth-surfaced, nodular and yellowish mass. Histopathologically, a classical lipoma resembles normal adipose tissue and it has multiple variants which are less commonly seen except fibrolipoma. Read More

    A case report of metastasis of malignant mesothelioma to the retromolar trigone.
    World J Surg Oncol 2016 Jul 20;14(1):188. Epub 2016 Jul 20.
    Patomed Pathology Laboratory, Gursel Mah, Darulaceze Cad, Eksioglu Is Merkezi, Kat:3, No: 36, D:4, Okmeydani, Istanbul, Turkey.
    Background: Malignant mesothelioma is a rare and aggressive tumor with a poor prognosis. Distant metastases are very rare, and the oral cavity metastases are exceedingly rare. Only a few cases with metastasis to oral gingiva are reported. Read More

    Molecular Characterization of Clear Cell Lesions of Head and Neck.
    J Clin Diagn Res 2016 May 1;10(5):ZE18-23. Epub 2016 May 1.
    Senior Lecturer, Department of Oral and Maxillofacial Pathology, I.T.S. Centre for Dental Studies and Research , Murad Nagar, Ghaziabad, Uttar Pradesh, India .
    The salivary glands, oral mucosa and jaws constitute a group of lesions which are heterogeneous in nature and are odontogenic, salivary or metastatic in origin. This group of tumours is termed as Clear Cell Tumours. Fixation artifacts are one of the most important reasons for the cell to appear clear but clearing of cells may also result from cytoplasmic accumulation of water, presence of glycogen within the cell, intermediate filaments, immature zymogen granules, or a paucity of cellular organelles. Read More

    Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis.
    Basic Clin Pharmacol Toxicol 2017 Jan 26;120(1):71-78. Epub 2016 Sep 26.
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
    The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy individuals, and a lozenge containing 25 mg bupivacaine was administered as single dose to 10 HNC patients with oral mucositis and as multiple doses to five patients with HNC. Blood samples were collected for 6 hr from the healthy individuals and 3 hr from the patients with HNC, respectively, after administration. Read More

    [Oral squamous cell carcinoma and lichen planus vs. lichenoid lesions. Case report].
    Rev Med Inst Mex Seguro Soc 2016 Sep-Oct;54(5):673-9
    Departamento de Dermatología, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Secretaría de Salud, Ciudad de México, México.
    Background: The development of squamous cell carcinoma from oral lichen planus is controversial. We report a case of intraoral squamous cell carcinoma, which presents together with lesions of oral lichen planus. The aim of this report was to analyze the problem to distinguish between the incipient changes of squamous cell carcinoma from the features described in oral lichen planus, in order to establish an accurate diagnosis of both entities. Read More

    Extranodal Marginal Zone Lymphoma of the Parotid Gland.
    J Maxillofac Oral Surg 2016 Jul 2;15(Suppl 2):346-50. Epub 2016 Mar 2.
    Pathology Department, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.
    Non Hodgkin lymphomas correspond to 25 % of all head and neck cancers. These rare tumors only include less than 5 % of malign tumors in parotid region. Differential diagnosis of these tumors cover many malign and benign tumors of the parotid gland. Read More

    Dermoid Cyst of Submental Region Mimicking Pilomatricoma.
    J Maxillofac Oral Surg 2016 Jul 1;15(Suppl 2):339-42. Epub 2015 Dec 1.
    Department of Oral and Maxillofacial Surgery, Farooqia Dental College and Hospital, Mysore, 570021 Karnataka.
    Diagnosis of midline neck swellings may give a myriad of options, ranging from ranula, thyroglossal duct cyst, cystic hygroma, cystic lymphangioma, epidermoid, dermoid and teratoid cysts to benign or malignant neoplasms of the mucosa or salivary glands and also rare skin appendage tumours like pilomatricoma or pilomatrix carcinoma. Various pitfalls are encountered in diagnosing these midline swellings as most of the features are overlapping. Careful history and examination have to be complemented with other diagnostic aids such as conventional radiography, ultrasonography, aspiration cytology and computed tomography to arrive at a correct diagnosis. Read More

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