12,765 results match your criteria Cancers of the Oral Mucosa


[Cutaneous Toxicity of Immune Checkpoint Inhibitors: A Narrative Review].

Acta Med Port 2020 May 4;33(5):335-343. Epub 2020 May 4.

Departamento de Dermatovenereologia. Centro Hospitalar Universitário de São João. Porto. Departamento de Dermatovenereologia. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Immune checkpoint inhibitors revolutionized anti-neoplastic treatment. Recently, the European Medicines Agency and the United States Food and Drug Administration approved inhibitors of various immune checkpoints, namely the cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 and its ligand. Despite the added benefits in the treatment of several neoplasms, immune checkpoint blockade may also be associated with multiple immune-related adverse events. Read More

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http://dx.doi.org/10.20344/amp.12424DOI Listing

Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.

J Contemp Dent Pract 2020 Jan 1;21(1):83-90. Epub 2020 Jan 1.

Department of Prosthodontics, Dr Hedgewar Smruti Rugna Seva Mandal Dental College and Hospital, Hingoli, Maharashtra, India.

Aim: To study the efficacy of topical curcumin mucoadhesive semisolid gel, triamcinolone acetonide/hyaluronidase mucoadhesive semisolid gel, and a combination of both in the treatment of oral submucous fibrosis (OSMF).

Materials And Methods: One hundred and twenty patients diagnosed with OSMF were randomly divided into groups I, II, and III. Each patients in groups I, II, and III was given professionally prepared mucoadhesive semisolid gel of curcumin, a combination of triamcinolone acetonide and hyaluronidase mucoadhesive semisolid gel, and a combination of all three, respectively. Read More

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January 2020

Oral Fibroma Removal With a Er,Cr:YSSG Laser.

Compend Contin Educ Dent 2020 May;41(5):e17-e22

Assistant Professor, Ostrow School of Dentistry, University of Southern California, Los Angeles, California; Private Practice, Santa Monica, California.

Fibromas often occur orally and are typically due to trauma to underlying connective tissue resulting in tissue enlargement. To prevent continuing trauma to the tissue, excision may be recommended, and biopsy is often indicated for these masses to confirm their diagnosis and to rule out a potential malignant cause. This article presents a case report in which a Er,Cr:YSSG laser was utilized for excision of an oral fibroma. Read More

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A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments.

Anticancer Res 2020 May;40(5):2701-2706

Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan

Background/aim: Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement.

Materials And Methods: A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. Read More

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http://dx.doi.org/10.21873/anticanres.14241DOI Listing

BMI-1 expression increases in oral leukoplakias and correlates with cell proliferation.

J Appl Oral Sci 2020 27;28:e20190532. Epub 2020 Apr 27.

Departamento de Odontologia Conservadora, Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.

Oral leukoplakia (OL) is a white lesion of an indeterminate risk not related to any excluded (other) known diseases or disorders that carry no increased risk for cancer. Many biological markers have been used in an attempt to predict malignant transformation; however, no reliable markers have been established so far. Objective To evaluate cell proliferation and immortalization in OL, comparing non-dysplastic (Non-dys OL) and dysplastic OL (Dys OL). Read More

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http://dx.doi.org/10.1590/1678-7757-2019-0532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185978PMC

Evaluation of the correlation between side effects to oral mucosa, salivary glands, and general health status with quality of life during intensity-modulated radiotherapy for head and neck cancer.

Support Care Cancer 2020 Apr 21. Epub 2020 Apr 21.

Dentistry and Stomatology Division, Ophthalmology, Otolaryngology and Head and Neck Surgery Department, Clinical Hospital of Ribeirão Preto School of Medicine, São Paulo University, Ribeirão Preto, SP, Brazil.

Purpose: The aim of this study was to evaluate the distribution of acute clinical complications that involve the oral cavity (oral mucositis and salivary flow), general health status (Karnofsky performance status scale (KPS) and weight), and quality of life using the worst performance throughout radiotherapy treatment by intensity-modulated radiation therapy (IMRT) in the head and neck region and to evaluate the correlation between these variables.

Methods: This prospective, longitudinal study evaluated 32 patients who were undergoing IMRT for head and neck tumors. The measures were collected weekly through standardized protocols and a quality of life questionnaire (UW-QOL version 4). Read More

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http://dx.doi.org/10.1007/s00520-020-05454-5DOI Listing

Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases.

J Clin Med 2020 Apr 17;9(4). Epub 2020 Apr 17.

Anatomic Pathology, Department of Emergency and Organ Transplantation, Università degli Studi di Bari Aldo Moro, 70100 Bari, Italy.

Metastases to orofacial tissues are infrequent, their incidence being 1-8% of malignant oral tumors, sometimes manifesting as the first clinical sign of an occult cancer. Renal cell carcinoma (RCC) is the second most common metastatic carcinoma to the oro-facial tissues, involving the jawbones, gingiva, oral mucosa, tongue or salivary glands. Also, RCC frequently displays a prominent clear cell component, which may predominate in the clear cell renal cell carcinoma subtype (CCRCC) and histologically mimic many other clear cell tumors, both benign and malignant, which can be epithelial (from keratinizing epithelia, cutaneous adnexa, salivary glands and odontogenic epithelium), melanocytic or mesenchymal in origin. Read More

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http://dx.doi.org/10.3390/jcm9041151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231269PMC

Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing.

Cancers (Basel) 2020 Apr 17;12(4). Epub 2020 Apr 17.

Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.

The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is not fully understood. We performed whole genome sequencing (WGS) and/or whole exome sequencing (WES) for 13 cases of OAML and sequenced 38 genes selected from this analysis in a large cohort of 82 OAML. Besides confirmation of frequent mutations in the genes transducin beta like 1 X-linked receptor 1 () and cAMP response element binding protein (), we newly identifed as a frequently mutated gene in OAML (11% of cases). Read More

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http://dx.doi.org/10.3390/cancers12040986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225979PMC

[Development of precancerous lesions of oral mucous membrane diseases and oral cancer animal models].

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Apr;38(2):198-204

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Precancerous lesions of oral mucous membrane diseases and oral cancer are common diseases in developing countries, especially in South Asia. However, the cancerous mechanism remains unclear, and no efficient treatment and prognosis measure are currently available. Thus, precancerous lesions of the oral mucosa and oral cancer animal models must be identified to further understand their function. Read More

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http://dx.doi.org/10.7518/hxkq.2020.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184277PMC

[Study on expression of LIM domain only protein 1 in SD rat oral buccal mucosa carcinogenesis induced by 4-nitro-quinoline N-oxide].

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Apr;38(2):133-138

Oral & Maxillofacial Reconstruction Laboratory, Southwest Medical University, Luzhou 646000, China;Dept. of Periodontal Mucosal Disease, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou 646000, China.

Objective: This work aimed to determine the expression changes in LIM domain only protein 1 (LMO1) in gene transcription and protein levels during oral squamous cell carcinoma (OSCC) development.

Methods: The tissues in this study were taken from our team's previous animal model building, and we performed hematoxylin-eosin (HE) staining on 49 cases. The pathological classification of the experiment group was determined on the basis of the abnormal epithelial hyperplasia degree. Read More

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http://dx.doi.org/10.7518/hxkq.2020.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184272PMC

Objective tumor distinction in 5-aminolevulinic acid-based endoscopic photodynamic diagnosis, using a spectrometer with a liquid crystal tunable filter.

Ann Transl Med 2020 Mar;8(5):178

Faculty of Medicine, Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University, Tottori, Japan.

Background: Recent improvement of the endoscopic system such as image enhancement has led to the better accuracy of the diagnosis of the gastric cancer. However, the objective and efficient detection method of the gastric cancer is still needed because the detection efficiency could sometimes be low due to the fact that the image enhancement diagnosis needs magnification for its full utilization. The photodynamic diagnosis (PDD) with oral intake of 5-aminolevulinic acid (5-ALA) has been widely used for the detection of the cancerous region for bladder cancer and glioblastoma. Read More

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http://dx.doi.org/10.21037/atm.2020.01.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154455PMC

Plexiform Schwannoma of the Oral Cavity: Report of Eight Cases and a Review of the Literature.

Head Neck Pathol 2020 Apr 8. Epub 2020 Apr 8.

Department of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, USA.

Plexiform schwannoma represents an unusual schwannoma variant, characterized by multinodular growth grossly and/or microscopically. A review of the English-language literature reveals only 28 previously reported cases involving the oral cavity, and herein we present 8 additional cases. Among these 36 patients, the average age at diagnosis was 28 years (range 5 to 62 years), with a female-to-male ratio of 1. Read More

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http://dx.doi.org/10.1007/s12105-020-01159-7DOI Listing

Can Sentinel Lymph Node Biopsy Predict Various Levels of Echelon Nodes in Oral Cancers?

Int Arch Otorhinolaryngol 2020 Apr 4;24(2):e125-e131. Epub 2019 Nov 4.

Department of Pathology, Post-Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.

 The efficacy of sentinel node biopsy in early stage oral cancer is well established. Its evolving role can be reinforced by further studies.  Analyzing the predictability of the levels of echelon nodes for various oral cavity tumor subsites on sentinel node biopsy. Read More

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http://dx.doi.org/10.1055/s-0039-1695762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828571PMC

SATB2 is frequently expressed in ossifying and non-ossifying peripheral oral fibroma of the gingival region but not in reactive fibromatous lesions from other intraoral sites.

Ann Diagn Pathol 2020 Apr 2;46:151510. Epub 2020 Apr 2.

Institute of Pathology, University Hospital, Erlangen, Germany.. Electronic address:

Ossifying and non-ossifying peripheral oral fibromas (POF) of the gingival and alveolar mucosa are localized, cellular, small fibrous nodular lesions likely resulting from diverse external/ internal physical and chemical irritation or injuries. A central nidus of metaplastic woven bone characterizes and defines the ossifying variant. The inherent tendency of these lesions to ossify remains elusive. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151510DOI Listing

An alternative to skin graft for superficial surgical defect in oral cancer surgery.

Braz J Otorhinolaryngol 2020 Mar 11. Epub 2020 Mar 11.

Azienda Sanitaria Universitaria Integrata di Trieste, Head and Neck Department, ENT Clinic, Trieste, Italy. Electronic address:

Introduction: After surgery for oral cavity cancer, superficial surgical defects are usually covered with a skin graft that can be harvested with different thicknesses depending on the reconstructive need. Despite its popularity and efficacy, this solution has the disadvantage of excessive harvesting times and scarring of the donor site. Other surgeons have proposed the use of bovine pericardium as a reconstructive solution. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.02.002DOI Listing

[Isolated neurofibroma of oral cavity. An unusual manifestation case report .]

Rev Fac Cien Med Univ Nac Cordoba 2020 03 12;77(1):45-48. Epub 2020 Mar 12.

Facultad de Odontología. Universidad Nacional de Córdoba.

Introduction: Neurofibroma (NF) is a benign tumor originated from neuronal cells, and can occur alone or multiple. Its manifestation within the oral cavity is rare, with a wide age range of appearance. This tumor occurs in a sessile-based nodular form, with slow growth and variable size. Read More

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http://dx.doi.org/10.31053/1853.0605.v77.n1.25244DOI Listing

[Potentially malignant disorders of the oral mucosa].

Authors:
Lotfi Ben Slama

Rev Prat 2019 Oct;69(8):856-860

Service de stomatologie et chirurgie maxillofaciale, groupe hospitalier Pitie-Salpêtrière- Charles Foix, département hospitalouniversitaire Fight Ageing and STress (DHU FAST) Paris, France ; Sorbonne Universités, UPMC Université de Paris 06, UMR 8256 B2A, Paris, France.

Potentially malignant disorders of the oral mucosa. The term "precancerous" is now abandoned in favor to « potentially malignant disorder » which provide a better view of the evolution a far from systematic. Of these disorders, leukoplakia is the most common while erythroplakia is rare. Read More

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October 2019

Endoscope-assisted Surgery in the Treatment of Dentigerous Cyst Involving the Maxillary Sinus - Report of Two Cases.

Chin J Dent Res 2020 ;23(1):71-76

Endoscopic techniques have been applied to oral and maxillofacial surgeries. Previous studies have proved their practicability in the treatment of osteomyelitis of the mandible and displaced residual roots in the maxillary sinus. In this report, two patients with dentigerous cysts in the maxillary sinus underwent endoscope-assisted curettage. Read More

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http://dx.doi.org/10.3290/j.cjdr.a44338DOI Listing

Ptaquiloside from bracken (Pteridium spp.) promotes oral carcinogenesis initiated by HPV16 in transgenic mice.

Food Funct 2020 Apr;11(4):3298-3305

Centro de Investigação e Tecnologia de Ciências Agroambientais e Biológicas (CITAB), Universidade de Trás-os-Montes e Alto Douro, UTAD, Vila Real, Portugal and Departamento de Ciências Veterinárias, Universidade de Trás-os-Montes e Alto Douro, UTAD, Vila Real, Portugal.

Bracken (Pteridium spp.) is a common weed that is consumed as food especially in Asia, and is suspected of promoting carcinogenesis induced by papillomaviruses in the digestive and urinary systems. This is particularly worrying because the incidence of head-and-neck cancers associated with the human papillomavirus (HPV) is rapidly increasing, and HPV co-carcinogens urgently need to be identified. Read More

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http://dx.doi.org/10.1039/d0fo00207kDOI Listing
April 2020
2.791 Impact Factor

Evaluation of immunohistochemical expression of TWIST in oral epithelial dysplasia and squamous cell carcinoma.

Int J Health Sci (Qassim) 2020 Mar-Apr;14(2):33-39

Department of Oral Pathology, Faculty of Dentistry, Tanta University, Tanta, Egypt.

Introduction: The major transcription factor, which modulates the epithelial-mesenchymal transition in different types of cancers, is known as TWIST oncogene. It binds to the promoter of E-cadherin and suppresses its transcription. The current study aims to assess the expression of TWIST protein in oral squamous cell carcinoma (OSCC), epithelial dysplasia (ED), and normal oral mucosa to verify whether such protein is useful as a marker in oral epithelium malignant transformation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069664PMC

Actinomycosis of the Tongue: A Case Report and Review of Literature.

Antibiotics (Basel) 2020 Mar 16;9(3). Epub 2020 Mar 16.

Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, 20142 Milano, Italy.

: Actinomycosis of the tongue is an uncommon, suppurative infection of lingual mucosa, caused by actinomyces. The clinical diagnosis may present serious difficulties because of its ability to mimic other lesions, including both benign and malignant neoplasms. : Here, we describe the case of a 52-years-old patient affected by an asymptomatic, tumor-like tongue swelling, then diagnosed as actinomycosis. Read More

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http://dx.doi.org/10.3390/antibiotics9030124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148533PMC

Phenome-Wide Scan Finds Potential Orofacial Risk Markers for Cancer.

Sci Rep 2020 Mar 17;10(1):4869. Epub 2020 Mar 17.

Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA.

Cancer is a disease caused by a process that drives the transformation of normal cells into malignant cells. The late diagnosis of cancer has a negative impact on the health care system due to high treatment cost and decreased chances of favorable prognosis. Here, we aimed to identify orofacial conditions that can serve as potential risk markers for cancers by performing a phenome-wide scan (PheWAS). Read More

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http://dx.doi.org/10.1038/s41598-020-61654-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078198PMC

[A Case of Laparoscopic Gastrojejunostomy for Duodenal Obstruction Caused by Unresectable Locally Advanced Pancreatic Cancer].

Gan To Kagaku Ryoho 2019 Dec;46(13):1937-1939

Dept. of General Surgery, Kyoundo Hospital.

The patient was an 85-year-old man who received chemotherapy with gemcitabine for 2 years 9 months under the diagnosis of unresectable locally advanced pancreatic body and tail cancer. He visited our hospital because of anorexia, upper abdominal fullness, and vomiting. A CT scan showed severe stenosis in the third portion of the duodenum, which was associated with the direct invasion of the advanced pancreatic cancer. Read More

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December 2019

[Oral Floor Reconstruction with Digastric Muscle Bipedicle Flap for Advanced Tongue Cancer in Very Elderly Patients-Report of Two Cases].

Gan To Kagaku Ryoho 2019 Dec;46(13):2185-2188

Division of Oral and Maxillofacial Surgery, Oki Hospital.

In recent years, the opportunity to treat oral cancer in elderly patients has been increasing because of the increased lifespan of individuals. Standard treatment for advanced tongue cancer involves reconstruction of the tongue with a free vascularized flap. However, this may not always be suitable for elderly patients because the procedure is lengthy and invasive and also because of their medical history. Read More

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December 2019

Linear verrucous epidermal nevus with oral manifestations: report of two cases.

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba.

Linear verrucous epidermal nevi (LVEN) are characterized by verrucous papules often coalescing into well-demarcated skin-colored or brown plaques following the lines of Blaschko. We present two new cases of LVEN with oral mucosa involvement and briefly discuss this very rare finding. In both cases, oral biopsies showed hyperkeratosis, acanthosis, and papillomatosis. Read More

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January 2020

Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor.

Am J Clin Pathol 2020 Mar 5. Epub 2020 Mar 5.

Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Objectives: The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior.

Methods: We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa027DOI Listing

Clinical Trials and Basic Research in Photodynamic Diagnostics and Therapies from the Center for Laser Diagnostics and Therapy in Poland.

Photochem Photobiol 2020 Feb 29. Epub 2020 Feb 29.

Department of Internal Medicine, Angiology, and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, Bytom, Poland.

The purpose of this review is to present an overview of the development of photodiagnostic and photodynamic therapy (PDD and PDT) techniques in Poland. The paper discusses the principles of PDD, including fluorescent techniques in determining precancerous conditions and cancers of the skin, digestive tract, bladder and respiratory tract. Methods of PDT of cancer will be discussed and the current state of knowledge as well as future trends in the development of photodynamic techniques will be presented, including the possibility of using photodynamic antimicrobial therapy. Read More

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http://dx.doi.org/10.1111/php.13243DOI Listing
February 2020

A Case of Fibrolipoma of the Hard Palate.

Bull Tokyo Dent Coll 2020 Mar 20;61(1):53-60. Epub 2020 Feb 20.

Department of Oral and Maxillofacial Surgery, Tokyo Dental College Chiba Dental Center.

An extremely rare case of fibrolipoma in the hard palate is presented and discussed with reference to the literature. An 85-year-old woman visited the Tokyo Dental College Chiba hospital in September 2016 with the chief complaint of a mass in the hard palate. The patient had first become aware of this mass several years earlier. Read More

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http://dx.doi.org/10.2209/tdcpublication.2019-0010DOI Listing

The effect of Maras powder and smoking on the microRNA deregulation of oral mucosa.

J Appl Oral Sci 2020 7;28:e20190382. Epub 2020 Feb 7.

Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey.

Objective: This study aimed to investigate the effects of Maras powder (a type of smokeless tobacco obtained from Nicotiana rustica Linn and mixed with the ashes of wood, especially from oak, walnut or grapevine) on the microRNA (miRNA) deregulation of oral mucosa, and it compares these effects with those of smoking.

Methodology: Oral mucosal samples were collected from 74 patients, consisting of 16 nonusers, 26 smokers, and 32 Maras powder users. Genes associated with oral cancer were selected and 90 microRNAs targeting these genes were identified. Read More

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http://dx.doi.org/10.1590/1678-7757-2019-0382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999115PMC
February 2020

The impact of peritumoral depapillation in cancers of the tongue.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Apr 5;129(4):369-376. Epub 2020 Feb 5.

Head and Neck Oncology Department, Tata Memorial Hospital, Mumbai, India. Electronic address:

Objectives: We observed that a prominent strip of depapillated mucosa surrounded tongue carcinomas. This study evaluates its correlation with other prognosticating factors.

Study Design: This prospective study included treatment naïve squamous carcinomas of tongue operated between January and December 2018. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.12.016DOI Listing

Molecular mechanisms of tobacco induced oral and oropharyngeal cancer: Results of a tissue microarray and immunohistochemistry-based study from a tertiary cancer center in India.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):7-12

Department of Surgical Oncology, Vydehi Institute of Oncology, Bengaluru, Karnataka, India.

Background: It is well established that chronic exposure to tobacco induces head and neck cancers but the exact etiopathogenesis is not known. Though studies have shown expression of TIMP1, EPS8 and AXL in cancers, their role in tobacco-induced cancers is not known. We aimed this study to evaluate the role of these molecules in oral and oropharyngeal squamous cell cancers (SCC). Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_783_18DOI Listing
February 2020

Herpesviruses in Head and Neck Cancers.

Viruses 2020 Feb 3;12(2). Epub 2020 Feb 3.

Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland.

Head and neck cancers arise in the mucosa lining the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. The etiology of head and neck cancers is complex and involves many factors, including the presence of oncogenic viruses. These types of cancers are among the most common cancers in the world. Read More

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http://dx.doi.org/10.3390/v12020172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077226PMC
February 2020

Oral liposarcoma in elderly: Case report and literature analysis.

Medicine (Baltimore) 2020 Feb;99(6):e18985

Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences.

Rationale: Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign lesion because of its asymptomatic and indolent clinical course. we report a case of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of buccal mucosa, provisionally diagnosed as lipoma.

Patient Concerns: A 97-year-old female was referred to dentistry and oral surgery department with an asymptomatic mass on the right buccal mucosa which had been present for an unknown period of time. Read More

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http://dx.doi.org/10.1097/MD.0000000000018985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015570PMC
February 2020

Multiclass classification of autofluorescence images of oral cavity lesions based on quantitative analysis.

PLoS One 2020 4;15(2):e0228132. Epub 2020 Feb 4.

Department of Physics, University of Central Florida, Orlando, FL, United States of America.

Background: Oral cancer is one of the most common diseases globally. Conventional oral examination and histopathological examination are the two main clinical methods for diagnosing oral cancer early. VELscope is an oral cancer-screening device that exploited autofluorescence. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228132PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999883PMC

LncRNA HOTAIR promotes the invasion and metastasis of oral squamous cell carcinoma through metastasis-associated gene 2.

Mol Carcinog 2020 04 28;59(4):353-364. Epub 2020 Jan 28.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.

Despite therapeutic advancements, there has been little improvement in the survival status of patients with oral squamous cell carcinoma (OSCC). HOX antisense intergenic RNA (HOTAIR) has been shown to be dysregulated in several cancer types. However, the roles of HOTAIR in OSCC remain largely unknown. Read More

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http://dx.doi.org/10.1002/mc.23159DOI Listing

Transoral robotic narrow field oropharyngectomy for tumours of the parapharyngeal space.

Int J Med Robot 2020 Jun 5;16(3):e2083. Epub 2020 Mar 5.

Department of Otolaryngology-Head and Neck Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

The advent of transoral robotic surgery (TORS) has allowed transoral approaches for parapharyngeal space (PPS) tumours to be re-evaluated. It provides enhanced visualisation and instrument access for appropriate tumours. We describe a specific technique, TORS narrow-field oropharyngectomy, that is ideal for benign PPS tumours which have been violated by intra-oral biopsy or incision and drainage. Read More

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http://dx.doi.org/10.1002/rcs.2083DOI Listing

Interspecialty referral of oesophagogastric and pharyngolaryngeal cancers delays diagnosis and reduces patient survival: A matched case-control study.

Clin Otolaryngol 2020 May 20;45(3):370-379. Epub 2020 Feb 20.

Department of Ear Nose and Throat Surgery, Poole Hospital NHS Foundation Trust, Poole, UK.

Objectives: Pharyngolaryngeal and oesophagogastric cancers present with swallowing symptoms and as such, their clinical evaluation traverses boundaries between different specialties. We studied the incidence and significance of interspecialty cancer referrals (ICRs), that is, pharyngolaryngeal cancers first evaluated by gastroenterology and oesophagogastric cancers first evaluated by otolaryngology.

Design: A subset analysis of our Integrated Aerodigestive Partnership's audit dataset, of all ICR patients, and an equal number of controls matched for age, sex and cancer subsite. Read More

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http://dx.doi.org/10.1111/coa.13510DOI Listing

Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis.

Cochrane Database Syst Rev 2020 Jan 27;1:CD012381. Epub 2020 Jan 27.

University of Western Ontario, Department of Medicine, London, ON, Canada.

Background: Tofacitinib is an oral Janus kinase (JAK) inhibitor which blocks cytokine signaling involved in the pathogenesis of autoimmune diseases including ulcerative colitis (UC). The etiology of UC is poorly understood, however research suggests the development and progression of the disease is due to a dysregulated immune response leading to inflammation of the colonic mucosa in genetically predisposed individuals. Additional medications are currently required since some patients do not respond to the available medications and some medications are associated with serious adverse events (SAEs). Read More

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http://dx.doi.org/10.1002/14651858.CD012381.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984444PMC
January 2020

GINGIVAL ULCERATIONS IN A PATIENT WITH ACUTE MYELOID LEUKEMIA: A case report and literature review.

Acta Clin Croat 2019 Sep;58(3):556-560

1Department of Oral Medicine, School of Dental Medicine, University of Zagreb; 2Department of Oral Diseases, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Hematology, School of Medicine and Zagreb University Hospital Centre, Zagreb, Croatia; 4Croatian Bone Marrow Donor Registry, Zagreb University Hospital Centre, Zagreb, Croatia.

A 40-year-old female patient was admitted to the Department of Oral Medicine due to oral ulcerations. Oral ulcerations were present on vestibular mucosa above teeth 21, 22, 25 and 26 and were 1 cm in diameter, and also around teeth 45 and 46. The patient had prolonged neutropenia due to therapy-related myelodysplastic syndrome that progressed to therapy-related acute myeloid leukemia. Read More

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http://dx.doi.org/10.20471/acc.2019.58.03.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971802PMC
September 2019

TERT promoter hotspot mutations and their relationship with TERT levels and telomere erosion in patients with head and neck squamous cell carcinoma.

J Cancer Res Clin Oncol 2020 Feb 20;146(2):381-389. Epub 2020 Jan 20.

Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, Padova, Italy.

Purpose: To evaluate the prevalence of two recurrent somatic mutations (-124 C>T and -146 C>T) within the promoter of the gene encoding telomerase reverse transcriptase (TERT) as well as their relationship with TERT level, telomeres length, and outcome in patients with head and neck squamous cell carcinomas (HNSCCs).

Methods: We evaluate the prevalence of TERT promoter mutations, TERT levels, and telomere length in paired cancer tissue and adjacent mucosa (AM) in a series of HNSCCs.

Results: Cancer tissue and AM specimens from 105 patients were analyzed. Read More

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http://dx.doi.org/10.1007/s00432-020-03130-zDOI Listing
February 2020

Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study.

PLoS One 2020 16;15(1):e0227738. Epub 2020 Jan 16.

Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway.

Objectives: Incidence of oral cavity squamous cell carcinomas is rising worldwide, and population characterization is important to follow for future trends. The aim of this retrospective study was to present a large cohort of primary oral cavity squamous cell carcinoma from all four health regions of Norway, with descriptive clinicopathological characteristics and five-year survival outcomes.

Materials And Methods: Patients diagnosed with primary treatment-naïve oral cavity squamous cell carcinomas at all four university hospitals in Norway between 2005-2009 were retrospectively included in this study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227738PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964975PMC

Intraoral salivary duct cyst: Report of rare entity.

J Oral Maxillofac Pathol 2019 Sep-Dec;23(3):429-431

Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, Maharashtra, India.

Salivary duct cysts (SDCs) are true cysts caused by obstruction of the salivary ducts and are rare in minor salivary glands. A 62-year-old male reported with a painless swelling in the left buccal mucosa for 2 years. Excision of the entire lesion was performed under local anesthesia following which histopathological examination was performed. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_191_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948038PMC
January 2020

Utility of Fine Needle Aspiration in Diagnosis of Intraoral Minor Salivary Gland Tumors.

J Cytol 2020 Jan-Mar;37(1):53-57. Epub 2019 Dec 23.

Department of ENT, Maulana Azad Medical College, New Delhi, India.

Objective: To evaluate the utility of intraoral fine-needle aspiration cytology (FNAC) in diagnosis of minor salivary gland neoplasms (MSGN) with application of Milan system of reporting salivary gland cytopathology; keeping histopathology as gold standard and to detail the cytological findings of MSGNs.

Method: Retrospective study between Jan 2008 and June 2017 (appro × 10 years) on the cytology of the minor salivary gland tumor along with the histopathological correlation. The relevant clinical data was collected from the medical record. Read More

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http://dx.doi.org/10.4103/JOC.JOC_62_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947729PMC
December 2019

Nasolabial cyst in buccal mucosa.

Indian J Dent Res 2019 Nov-Dec;30(6):957-959

Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Teynampet, Chennai, Tamil Nadu, India.

Nasolabial cysts are a rare non-odontogenic, soft-tissue, developmental cyst reported till date in the sublabial area and anterior maxillary region. The cyst is a slowly enlarging asymptomatic swelling and non-painful. The cyst is believed to be associated with remnants of the nasolabial duct. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_861_19DOI Listing
January 2020

Proline-Dependent Induction of Apoptosis in Oral Squamous Cell Carcinoma (OSCC)-The Effect of Celecoxib.

Cancers (Basel) 2020 Jan 6;12(1). Epub 2020 Jan 6.

Department of Pharmaceutical Analysis, Medical University of Bialystok, Mickiewicza 2D, 15-522 Białystok, Poland.

: Oral squamous cell carcinoma remains a significant worldwide public health challenge, associated with high morbidity and mortality. Treatment of this type of cancer lacks effective medication. Moreover, there are very few specific biomarkers that are useful in early diagnosis or treatment optimisation. Read More

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http://dx.doi.org/10.3390/cancers12010136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016823PMC
January 2020

Infrahyoid flap revisited - A head and neck surgical perspective in the Indian setting.

Indian J Cancer 2020 Jan-Mar;57(1):62-69

Department of Head and Neck Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Purpose: In India, head and neck cancer contributes to about 35% of all malignancies. Among head and neck squamous cell cancers, buccal mucosa and tongue are the most common subsites. Reconstruction of defects after resection of primary in these subsites with acceptable cosmetic and functional outcomes remains a challenging task. Read More

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http://dx.doi.org/10.4103/ijc.IJC_460_18DOI Listing
January 2020

Total Lip Reconstruction after Excision of Cancer with Composite Radial Forearm Palmaris Longus Tendon Free Flap.

Mymensingh Med J 2020 Jan;29(1):149-155

Dr Hasib Rahman, Associate Professor, Plastic Surgery, Sylhet MAG Osmani Medical College and Hospital, Sylhet, Bangladesh; E-mail:

Reconstruction of total lip is a challenging task for a plastic surgeon. It becomes more complicated when there is loss of additional tissues like angle of mouth, buccal mucosa or floor of the mouth. Radial forearm flap with palmaris longus tendon provides an easier but reliable technique for three dimensional lip reconstructions with good functional and aesthetic outcome. Read More

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January 2020

A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors.

Vet Microbiol 2020 Jan 2;240:108491. Epub 2019 Nov 2.

Department of Veterinary Medicine and Surgery, University of Missouri, 900 E. Campus Drive, Columbia, MO 65211, USA.

Feline oral squamous cell carcinoma (FOSCC) may be the best naturally-occurring model of human head and neck squamous cell carcinoma (HNSCC). HNSCC can be broadly divided into human papillomavirus (HPV)-negative cancers and HPV-positive cancers where HPV is the causative agent. Previous studies in FOSCC have used both species-specific and species-nonspecific PCR primers that may be insensitive to the detection of PVs and other viruses that may be divergent from known sequences. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.108491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117531PMC
January 2020

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.

Int J Oral Sci 2020 01 2;12(1). Epub 2020 Jan 2.

Molecular Oncology Unit. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.

Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures that differentiate as teeth. Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog, MAPK and WNT/β-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. Read More

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http://dx.doi.org/10.1038/s41368-019-0067-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946653PMC
January 2020

Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population.

Med Oral Patol Oral Cir Bucal 2020 01 1;25(1):e84-e88. Epub 2020 Jan 1.

Background: The frequency and distribution of oral potentially malignant disorders (OPMD) may vary among different populations. The aim of the present study was to evaluate the clinical-pathological characteristics of OPMD diagnosed in a Brazilian oral pathology laboratory over a period of 11 years.

Material And Methods: All cases diagnosed as leukoplakia, speckled leukoplakia, erythroplakia, and actinic cheilitis from 2005 to 2015 were analyzed. Read More

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http://dx.doi.org/10.4317/medoral.23197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982984PMC
January 2020