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Sci Rep 2022 May 18;12(1):8261. Epub 2022 May 18.

Oral Pathology and Oral Radiology, Faculty of Medicine, University of Turku, Turku, Finland.

Oral epithelial dysplasia (OED) is considered a risk for oral squamous cell carcinoma (OSCC). A meta-analysis estimated a mean malignant transformation rate of 12.1% (95% CI 8. Read More

Medicine (Baltimore) 2022 May 13;101(19):e29276. Epub 2022 May 13.

Department of Pathology, Eulji University Hospital, Eulji University College of Medicine, Daejeon, Korea.

Introduction: Extraskeletal soft tissue chondroma (STC) is a rare benign tumor. Soft-tissue chondromas rarely occur in the oral cavity. In this study, we aimed to confirm a slow-growing tongue mass using magnetic resonance imaging. Read More

Klin Lab Diagn 2022 Apr;67(4):219-226

Federal budgetary institution of science "Nizhny Novgorod research Institute of epidemiology and microbiology named after academician I.N. Blokhina Rospotrebnadzor".

Purpose of the study improving the diagnosis of precancerous diseases and cancer of the oral mucosa using fluorescent immunocytochemical studies by direct immunofluorescence. A clinical laboratory examination of 111 patients was carried out: 46 patients with squamous cell carcinoma of the oral mucosa, 35 people with precancerous lesions (17 leukoplakia, 18 - oral lichen planus) and 30 healthy people. All patients underwent a traditional cytological examination and an additional immunocytochemical examination by direct immunofluorescence, the expression levels of tumor markers P53, P16 and Ki67 were determined. Read More

J Oral Maxillofac Res 2022 Jan-Mar;13(1):e5. Epub 2022 Mar 31.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of AthensGreece.

Background: Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child.

Methods: A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. Read More

Cancers (Basel) 2022 May 9;14(9). Epub 2022 May 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Molecular and Cellular Oncology, University Medical Center, 55131 Mainz, Germany.

Treatment success of head and neck cancer (HNC) is still hampered by tumor relapse due to metastases. Our study aimed to identify biomarkers by exploiting transcriptomics profiles of patient-matched metastases, primary tumors, and normal tissue mucosa as well as the HNC cohort data sets. Analyses identified osteoblast-specific factor 2 (OSF-2) as significantly overexpressed in lymph node metastases and primary tumors compared to normal tissue. Read More

Cancers (Basel) 2022 Apr 27;14(9). Epub 2022 Apr 27.

Intercollegiate Faculty of Biotechnology, The University of Gdańsk and the Medical University of Gdańsk, 80-210 Gdańsk, Poland.

(1) Purpose: In this article, the authors decided to systematically review the available literature to identify potential correlations regarding secondary oral carcinoma occurring after hematological systemic treatment and oral chronic graft-versus-host disease. (2) Methods: Medline (PubMed) and Scopus (Elsevier) databases were searched, including articles from the years 2002-2022. The 33 unique results were assessed by a PRISMA flowchart, and we rejected 24 papers and included 9 articles in the review. Read More

Int J Environ Res Public Health 2022 May 4;19(9). Epub 2022 May 4.

Department of Head, Neck and Sense Organs, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Background: Any oral potentially malignant disorders (OPMDs) must be regularly monitored through clinical examination to detect any possible malignant transformation. Conventional intraoral exams, however, can be difficult because these conditions may resemble benign lesions. For this reason, several non-invasive diagnostic technologies have been developed to help the clinician in detecting and distinguishing between cancerous and benign lesions. Read More

Int J Mol Sci 2022 Apr 27;23(9). Epub 2022 Apr 27.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.

Oral squamous cell carcinoma (OSCC) carcinogenesis involves heterogeneous tumor cells, and the tumor microenvironment (TME) is highly complex with many different cell types. Cancer cell-TME interactions are crucial in OSCC progression. ()-frequently pre-sent in the oral potentially malignant disorder (OPMD) lesions and OSCC tissues-promotes malignant transformation. Read More

Int J Mol Sci 2022 Apr 26;23(9). Epub 2022 Apr 26.

Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing 100069, China.

With the development of psychology and medicine, more and more diseases have found their psychological origins and associations, especially ulceration and other mucosal injuries, within the digestive system. However, the association of psychological factors with lesions of the oral mucosa, including oral squamous cell carcinoma (OSCC), burning mouth syndrome (BMS), and recurrent aphthous stomatitis (RAS), have not been fully characterized. In this review, after introducing the association between psychological and nervous factors and diseases, we provide detailed descriptions of the psychology and nerve fibers involved in the pathology of OSCC, BMS, and RAS, pointing out the underlying mechanisms and suggesting the clinical indications. Read More

Swiss Dent J 2022 May;132(5):343-348

Klinik für Mund-, Kiefer-, Gesichts- und Oralchirurgie, Luzerner Kantonsspital, Luzern, Schweiz.

Lymphomas are malignant neoplasms of mature and immature B-cells, T-cells or NK-cells at various stages of differentiation. They predominantly occur in lymphoid tissues, manifestations in the oral cavity are rare: 3.5% of all oral malignancies are lymphomas. Read More

Clin Lab 2022 05;68(5)

Background: Radiotherapy-induced oral mucositis (RIOM) is the most common toxicity associated with radiotherapy for nasopharyngeal carcinoma (NPC). Patients with RIOM become malnourished, which can affect the delivery and dose of radiotherapy. The value of personalizing nutrition recommendations for cancer prevention and management is increasingly recognized. Read More

BMC Oral Health 2022 05 6;22(1):165. Epub 2022 May 6.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Morphological evaluation of oral mucosal biopsy is sometimes inconclusive, which may delay the diagnosis and treatment of oral squamous malignancy. Immunohistochemical biomarkers denoting oral squamous malignancy would be clinically helpful in such scenario.

Methods: We first studied the expression patterns of four potential biomarkers (cytokeratin 13, cytokeratin 17, Ki-67 and laminin 5 gamma 2 chain) in an exploratory cohort containing 54 surgical specimens from confirmed oral squamous malignancies. Read More

Pediatr Dermatol 2022 May 6. Epub 2022 May 6.

Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.

Focal epithelial hyperplasia (FEH), or Heck's disease, is an uncommon HPV-related dermatosis that presents with multiple discrete papules or nodules on the lips, tongue, and gingival or oral mucosa. Treatment is often sought due to cosmesis, social stigma, and functional impairment. Treatment is challenging and a variety of treatment modalities have been attempted with varying degrees of success. Read More

Pan Afr Med J 2022 17;41:141. Epub 2022 Feb 17.

Department of Community Medicine, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Int J Oncol 2022 Jun 6;60(6). Epub 2022 May 6.

Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109‑1078, USA.

For decades, the link between poor oral hygiene and the increased prevalence of oral cancer has been suggested. Most recently, emerging evidence has suggested that chronic inflammatory diseases from the oral cavity (e.g. Read More

Cureus 2022 Mar 31;14(3):e23716. Epub 2022 Mar 31.

Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, IND.

Introduction Oral mucositis is a common and potentially serious complication of radiation in head and neck cancer treatment. Severe mucositis causes pain, difficulty in chewing and swallowing that can cause treatment breaks and can cause treatment failures leading to local recurrence or a decrease in overall survival. The contouring of the planning target volume (PTV) and organ at risk (OAR) leaves some undefined regions on computed tomography imaging. Read More

Otolaryngol Head Neck Surg 2022 May 3:1945998221098011. Epub 2022 May 3.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.

Objective: We aim to more accurately characterize the current distribution and rates of squamous cell carcinoma (SCC) cases across various oral cavity subsites in the United States.

Study Design: Retrospective cohort.

Setting: Database study evaluating cancer incidence in the United States from 2001 to 2017. Read More

Ann Plast Surg 2022 Apr 23. Epub 2022 Apr 23.

Background: Advanced oral cancer entailing extensive resection of large parts of the mucosa, bone, and skin require reconstructions with composite free flaps. Our aim was to analyze the outcomes of those oral squamous cell carcinomas requiring fibular osteocutaneous free flaps with large skin defects.

Methods: Perioperative course and histopathological and survival outcomes of 246 consecutive patients warranting composite fibular flaps from January 2010 to June 2015 at Tata Memorial Hospital, Mumbai, India, were retrospectively analyzed. Read More

J Med Case Rep 2022 Apr 29;16(1):178. Epub 2022 Apr 29.

Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, 3311-1 Yakushiji , Shimotsuke-shi, Tochigi, 329-0498, Japan.

Background: It is very important to determine the indication of mold radiotherapy for the radical treatment of oral cancer. We investigated eight patients with oral squamous cell carcinoma who were treated by radical irradiation with mold radiotherapy using a customized device.

Methods: The subject is a case of curable superficial oral cancer of a few millimeters, or cancer of a size that can be cured by the placement of the radiation source. Read More

Heart Surg Forum 2022 Apr 22;25(2):E284-E287. Epub 2022 Apr 22.

Department of Pathology, Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University, Zhejiang, China.

Composite hemangioendothelioma (CHE) is an extremely rare vascular neoplasm that is characterized by an admixture of benign, low-grade malignant, and malignant vascular components. It is usually located superficially in the dermis and subcutis of the extremities, and other sites involved include the head and neck region, oral mucosa, and viscera of the kidney and spleen. CHE has a low-grade malignant potential because it is locally aggressive. Read More

BMC Oral Health 2022 04 22;22(1):138. Epub 2022 Apr 22.

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Background: Few models about the personalized prognosis evaluation of buccal mucosa cancer (BMC) patients were reported. We aimed to establish predictive models to forecast the prognosis of BMC patients.

Methods: The complete clinicopathological information of BMC patients from the surveillance, epidemiology and end results program was collected and reviewed retrospectively. Read More

Int J Mol Sci 2022 Apr 15;23(8). Epub 2022 Apr 15.

REQUIMTE/LAQV-Instituto Superior de Engenharia do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.

Cancer, a major world public health problem, is associated with chemotherapy treatments whose administration leads to secondary concerns, such as oral mucositis (OM). The OM disorder is characterized by the presence of ulcers in the oral mucosa that cause pain, bleeding, and difficulty in ingesting fluids and solids, or speaking. Bioactive compounds from natural sources have arisen as an effective approach for OM. Read More

World J Surg Oncol 2022 Apr 21;20(1):127. Epub 2022 Apr 21.

Department of Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.

Background: Basal cell carcinoma (BCC) is the most common cancer worldwide. Most of BCCs can be detected in the early stages and are generally well controlled with local resection. Despite the high incidence of BCC, metastasis is rarely observed. Read More

Cancer Treat Res Commun 2022 10;31:100558. Epub 2022 Apr 10.

Faculty of Dentistry, Minia University, Egypt.

Purpose: The current study was directed to investigate the effectiveness of docosahexaenoic acid (DHA) as a chemopreventive agent on experimentally induced hamster buccal pouch (HBP) carcinogenesis.

Material And Methods: In this study we used 40 Syrian male hamsters, five weeks old, were divided into 4 groups (GI, GII, GIII, and GIV) of 10 animals in each as follows, GI: Topical application of liquid paraffin alone (thrice a week for 14 weeks), GII: Topical application of 7, 12 dimethyl benz[a]anthracene (DMBA) alone (0.5% in liquid paraffin, thrice a week for 14 weeks), GIII: Topical application of DMBA (0. Read More

Int J Environ Res Public Health 2022 04 4;19(7). Epub 2022 Apr 4.

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Dirofilariasis is an endemic infestation in tropical and subtropical countries caused by about 40 different species. It rarely occurs in the oral cavity and is mostly presented as mucosal and submucosal nodules. Differential diagnoses include lipoma, mucocele, and pleomorphic adenoma. Read More

Int J Environ Res Public Health 2022 03 27;19(7). Epub 2022 Mar 27.

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, São Paulo State University (Unesp), São José dos Campos 12245-000, Brazil.

Background: Cancer is currently a major public health problem worldwide, with a marked increase of about 70% in the number of expected diagnosed cases over the next two decades. The amount of tobacco and alcohol consumed is calculated based on the subjective information provided by the user. Tobacco exposure can be assessed using the Fagerström Test for Cigarette Dependence (FTCD) and alcohol consumption by the Alcohol Use Disorder Identification Test (AUDIT). Read More

Int J Mol Sci 2022 Mar 26;23(7). Epub 2022 Mar 26.

Department of Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork, T12 YN60 Cork, Ireland.

Oral Squamous Cell Carcinoma (OSCC) is the most common malignant cancer affecting the oral cavity. It is characterized by high morbidity and very few therapeutic options. Angiotensin (Ang)-(1-7) is a biologically active heptapeptide, generated predominantly from AngII (Ang-(1-8)) by the enzymatic activity of angiotensin-converting enzyme 2 (ACE 2). Read More

Cancers (Basel) 2022 Apr 2;14(7). Epub 2022 Apr 2.

Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Background: The involvement of immune cell infiltration and immune regulation in the progression of oral squamous cell carcinoma (OSCC) is shown. Anti-PD-1 therapy is approved for the treatment of advanced OSCC cases, but not all patients respond to immune checkpoint inhibitors. Hence, further targets for therapeutic approaches are needed. Read More

J Cancer Res Ther 2022 Jan-Mar;18(1):55-65

Department of Oral and Maxillofacial Pathology and Microbiology, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Context: Areca nut, a causative factor for oral submucous fibrosis (OSMF), is identified as a Group 1 human carcinogen. Oral squamous cell carcinoma (OSCC) associated with OSMF is now one of the most common malignancies in South and Southeast Asian countries.

Aim: The present study was aimed to have clarity whether OSCC associated with OSMF is a pathologically different disease having different prognosis. Read More

Sci Rep 2022 04 4;12(1):5622. Epub 2022 Apr 4.

Faculty of Dental Medicine and Oral Health Sciences, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, QC, H3A 1G1, Canada.

As evidence has been linking the oral bacterium Fusobacterium nucleatum (F. nucleatum) to colorectal tumorigenesis, we aimed to produce preliminary data on the expression of F. nucleatum in both oral and colorectal body sites in cases diagnosed with colorectal neoplasms (CRN) and CRN-free controls. Read More