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    11715 results match your criteria Cancers of the Oral Mucosa

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    Epithelioid hemangioma in the oral mucosa – A case report.
    Srp Arh Celok Lek 2016 Sep-Oct;144(9-10):535-40
    Introduction: Epithelioid hemangioma is an uncommon benign vasoproliferative neoplasm that usually manifests as multiple red nodules in middle-aged adults

    Case Outline: 52-year-old male patient presented with a one-year history of a nodular lesion in the left buccal mucosa measuring 3 cm. The clinical hypothesis was lipoma. An excisional biopsy revealed a circumscribed lesion composed of lobules of vessels with perceptible or poor lumina, associated with a prominent inflammatory infiltrate consisting of eosinophils, histiocytes and chronic inflammatory cells. Read More

    Effects of green tea on miRNA and microbiome of oral epithelium.
    Sci Rep 2018 Apr 12;8(1):5873. Epub 2018 Apr 12.
    Department of Oral Medicine & Diagnostic Sciences, Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL, USA.
    Consumption of green tea (GT) extracts or purified catechins has shown the ability to prevent oral and other cancers and inhibit cancer progression in rodent models, but the evidence for this in humans is mixed. Working with humans, we sought to understand the source of variable responses to GT by examining its effects on oral epithelium. Lingual epithelial RNA and lingual and gingival microbiota were measured before and after 4 weeks of exposure in tobacco smokers, whom are at high risk of oral cancer. Read More

    A challenging diagnosis: Case report of oral metastasis from gastric adenocarcinoma mimicking pyogenic granuloma.
    Medicine (Baltimore) 2018 Mar;97(13):e9934
    Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo.
    Rationale: Oral metastases occur more commonly in bone, but can also manifest in soft tissues and eventually resemble a reactive lesion. Few cases of oral metastases mimicking reactive lesions in soft tissues have been reported to date.

    Patient Concerns: We report a metastasis of gastric carcinoma (GC) to the oral mucosa without bone involvement in a 43 yom clinically and microscopically mimicking a reactive lesion. Read More

    The Submental Island Flap Is a Viable Reconstructive Option for a Variety of Head and Neck Ablative Defects.
    Ochsner J 2018 ;18(1):53-58
    Department of Otolaryngology, Tulane University Medical Center, New Orleans, LA.
    Background: The submental island flap (SIF) is a pedicled flap based upon the submental artery and vein. Its utility in reconstruction following ablative head and neck procedures has been applied to various subsites including skin, lip, buccal mucosa, retromolar trigone, parotidectomy defects, and tongue. We review our experience using the SIF for reconstruction following tumor ablation. Read More

    Predictors of locoregional recurrence in early stage buccal cancer with pathologically clear surgical margins and negative neck.
    Acta Otorrinolaringol Esp 2018 Mar 15. Epub 2018 Mar 15.
    Department of Otorhinolaryngology-Head and Neck Surgery, Liaquat National Hospital & Medical College, Karachi, Pakistan.
    Objective: To identify the significant predictors of locoregional recurrence in early stage squamous cell carcinoma (SCC) of buccal mucosa with pathologically clear surgical margins and negative neck.

    Method: Seventy-three patients who underwent per oral wide excision and supraomohyoid neck dissection for early stage buccal SCC with clear surgical margins (>5mm margins each) and negative neck (N0) were included. None of the patients received postoperative radiotherapy or chemotherapy. Read More

    The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer.
    Braz J Otorhinolaryngol 2018 Mar 1. Epub 2018 Mar 1.
    Poznan University of Medical Sciences, Department of Otolaryngology, Head and Neck Surgery, Poznan, Poland.
    Introduction: Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer.

    Objective: The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the larynx mucosa in terms of specifying surgical margins.

    Methods: Forty-four consecutive T1-T2 glottic cancers treated with trans-oral laser microsurgery Type I-VI cordectomy were presented. Read More

    Laminated chitosan-based composite sponges for transmucosal delivery of novel protamine-decorated tripterine phytosomes: Ex-vivo mucopenetration and in-vivo pharmacokinetic assessments.
    Carbohydr Polym 2018 May 3;188:108-120. Epub 2018 Feb 3.
    Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt.
    In the current study, laminated chitosan (CS):hydroxypropyl methylcellulose (HPMC) composite sponges were exploited as solid matrices for buccal delivery of tripterine phytosomes functionalized with novel mucopenetrating protamine layer (PRT-TRI-PHY). Tripterine (TRI) is a herbal drug widely investigated as a potential anticancer candidate against various types of cancers. However, clinical use of TRI is handicapped by its low oral bioavailability. Read More

    Sonographic imaging of fibrosis of oral mucosa and its correlation with clinical staging in oral submucous fibrosis.
    J Cancer Res Ther 2018 Jan-Mar;14(2):394-397
    Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India.
    Background And Objectives: To evaluate the efficacy of ultrasonography (USG) as a noninvasive tool in assessing the severity of oral submucous fibrosis (OSMF) by measuring the submucosal thickness and also to correlate the sonographic changes with clinical staging.

    Materials And Methods: The submucosal thickness of the upper and lower labial mucosa, anterior and posterior portions of the right and left buccal mucosa were measured using ultrasound in 64 patients comprising of 32 OSMF patients and 32 controls. Among the controls, 16 were with a habit of chewing gutkha and 16 were without any habit history. Read More

    Low Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Oral Squamous Cell Carcinoma.
    J Dent (Shiraz) 2018 Mar;19(1):6-14
    MD Pathology, Dept. of Pathology, Rashtra Sant Tukodoji Regional Cancer Hospital and Research Centre, Nagpur, India.
    Statement Of The Problem: Regional lymph nodes are the nodes draining lymph from region around the tumor and presence of metastatic tumor in regional lymph nodes is the most important prognostic factor for malignant tumors of epithelial origin. Lymphangiogenesis is associated with an increased incidence of regional lymph nodes metastasis and is possibly an essential step for metastasis. Tumor cells secrete lymphangiogenic cytokines, which results in formation of lymphatic vessels within and around the tumor and act as portals for tumor spread. Read More

    mTORC1 and mTORC2 Expression Levels in Oral Squamous Cell Carcinoma: An Immunohistochemical and Clinicopathological Study.
    Anticancer Res 2018 03;38(3):1623-1628
    Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Background/aim: Mammalian target of rapamycin (mTOR) plays a critical role in the regulation of tumor cell motility, invasion and cancer cell metastasis. mTOR consists of two separate multi-protein complexes, mTOR complex (mTORC) 1 and mTORC2.

    Materials And Methods: We investigated the expression levels of mTORC1 and mTORC2 immunohistochemically in oral squamous cell carcinoma (OSCC). Read More

    [Epidemiology of oral HPV infection in young healthy individuals].
    Rev Chilena Infectol 2017 Dec;34(6):557-562
    Centro de Investigaciones Regionales "Dr. Hideyo Noguchi" Campus de Ciencias de la Salud Unidad de Ciencias Biomédicas Inalámbrica, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
    Background: HPV infection is the most common sexually transmitted viral infection, and is associated with several neoplasms.

    Aim: To describe the epidemiology, natural history and risk factors associated with oral HPV infection in asymptomatic young adults.

    Methods: A prospective and longitudinal study was conducted, including subjects without oral pathology, who were sampled from the oral mucosa. Read More

    Primary Oral Mucosal Melanomas - Two Case Reports and Comprehensive Literature Review.
    Acta Clin Croat 2017 Jun;56(2):323-330
    Private Dental Surgery, Sarajevo, Bosnia and Herzegovina.
    Oral melanoma (OM) occurs from activated or genetically altered epidermal melanocytes. There is no scientific evidence that OM can be linked to physical, chemical and thermal irritation, or to other risk factors of the oral cavity. According to fi gures from various countries, OM accounts for 0. Read More

    Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment.
    Med Oral Patol Oral Cir Bucal 2018 Mar 1;23(2):e237-e247. Epub 2018 Mar 1.
    Université de Nantes UFR d'Odontologie, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 1, France,
    Background: Oral cancer is a public health issue worldwide. Oral potentially malignant disorders (OMPDs) are lesions of the oral mucosa that are predisposed to malignant transformation. The mainstay of OMPDs treatment around the world is now the carbon dioxide (CO2) laser but the reported recurrence and malignant transformation rates vary widely in the literature. Read More

    Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth).
    Int J Pharm 2018 Apr 6;541(1-2):157-166. Epub 2018 Feb 6.
    Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address:
    Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. Patients with xerostomia suffer symptoms that severely affect their health as well as physical, social and emotional aspects of their life. The current management of xerostomia is the application of saliva substitutes or systemic delivery of saliva-stimulating cholinergic agents, including pilocarpine, cevimeline or bethanechol tablets. Read More

    Prevalence and genotypes of human papillomavirus in saliva and tumor samples of head and neck cancer patients in Hungary.
    Infect Genet Evol 2018 Apr 1;59:99-106. Epub 2018 Feb 1.
    Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary. Electronic address:
    In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hungary, data regarding HPV prevalence in HNSCCs is scarce. We collected biopsy and saliva samples from patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) and tested them for the presence of HPV using the PCR consensus primer set MY09/11 and the GP5+/6+ primer pair. Read More

    Effect of neoadjuvant chemotherapy and its correlation with HPV status, EGFR, Her-2-neu, and GADD45 expression in oral squamous cell carcinoma.
    World J Surg Oncol 2018 Jan 31;16(1):20. Epub 2018 Jan 31.
    Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.
    Background: Head and neck cancers are the commonest cancer in Southeast Asia. Despite being a surface cancer, it is associated with significant morbidity as despite early detection by the patients they often report for treatment late and hence are associated with poor prognosis. The role of neoadjuvant chemotherapy in head and neck cancer is still under evaluation; there is a large subgroup of population that does not respond to chemotherapy, and hence, most studies have failed to show any survival benefit. Read More

    Gingival Leiomyosarcoma in a Young Woman: Case report and literature review.
    Sultan Qaboos Univ Med J 2017 Nov 10;17(4):e472-e476. Epub 2018 Jan 10.
    Department of Ear, Nose & Throat, University of Siena, Siena, Italy.
    Leiomyosarcoma (LMS) is a rare mesenchymal malignancy, of which 3-10% of cases occur in the head and neck region. We report a 22-year-old woman who was referred to the University Hospital of Siena, Italy, in 2016 with an ostensibly benign asymptomatic lump on the mandibular . The lesion grew rapidly, causing in the right ear. Read More

    Low-grade myofibroblastic sarcoma of gastric cardia on 18F-FDG positron emission tomography/computed tomography: An extremely rare case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9720
    Department of Nuclear Medicine.
    Rationale: Low-grade myofibroblastic sarcoma (LGMS) is a rare mesenchyme-derived tumor, which usually occurs in head, neck (especially tongue and mouth), and limbs. In this report, we described a case of gastric LGMS by F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), which has not been reported previously.

    Patient Concerns: A 51-year-old female patient was admitted to our hospital with upper abdominal discomfort for 1 year and gradually increased eating difficulties over the last 3 months. Read More

    Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16 Oral Tumors and Immunologic Control.
    Cancer Immunol Res 2018 Jan 23. Epub 2018 Jan 23.
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
    Human papillomavirus type 16 (HPV16) is the etiologic factor for cervical cancer and a subset of oropharyngeal cancers. Although several prophylactic HPV vaccines are available, no effective therapeutic strategies to control active HPV diseases exist. Tumor implantation models are traditionally used to study HPV-associated buccal tumors. Read More

    Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.
    PLoS One 2018 16;13(1):e0190709. Epub 2018 Jan 16.
    Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
    Background: Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests. In this pilot study, we applied global gene-expression analysis on serial human oral mucosa tissue and blood cells from patients with tonsil squamous cell cancer (TSCC) to identify genes involved in mucositis pathogenesis.

    Methods And Findings: Eight patients with TSCC each provided consecutive buccal biopsies and blood cells before, after 7 days of RT treatment, and 20 days following RT. Read More

    Induction Chemotherapy in Technically Unresectable Locally Advanced T4a Oral Cavity Squamous Cell Cancers: Experience from a Regional Cancer Center of South India.
    Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):490-494
    Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
    Objectives: The present study aimed to investigate the efficacy, toxicity, and impact of induction chemotherapy (IC) in technically unresectable T4a oral cavity squamous cell cancers (OSCCs).

    Materials And Methods: Patients diagnosed with technically unresectable locally advanced T4a OSCC from January 2013 and November 2016 at our center, who received 2-3 cycles of IC and then assessed for resectability, were reviewed retrospectively. Patients' profile, response rates and toxicity of IC, resectability status, and overall survival (OS) were evaluated. Read More

    Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa.
    Oncoimmunology 2018 6;7(2):e1388484. Epub 2017 Nov 6.
    Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China.
    Curbing PD-1 immunosuppressive signaling represents an effective immune awakening or immune-reactivation approach for tumor eradication for many cancers. Yet, the potential involvement of this critical PD-1 immunosuppressive signaling in malignant transformation of epithelial cells to pre-cancerous or cancerous lesions is largely unknown. In this study, we demonstrate that PD-1 signaling is critically involved in malignant transformation of oral mucosa upon carcinogen exposure . Read More

    Local Acetaldehyde-An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis.
    Cancers (Basel) 2018 Jan 5;10(1). Epub 2018 Jan 5.
    Research Unit on Acetaldehyde and Cancer, University of Helsinki, Biomedicum Helsinki P.O. Box 63, 00014 Helsinki, Finland.
    The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a significant risk factor for oral and esophageal carcinogenesis and is characterized by a dysbiotic microbiome. Dysbiosis leads to increased growth of opportunistic pathogens (such as yeasts) and may cause an up to 100% increase in the local ACH production, which is further modified by organ-specific expression and gene polymorphisms of ethanol-metabolizing and ACH-metabolizing enzymes. Read More

    Focus on periodontal disease and colorectal carcinoma.
    Oral Implantol (Rome) 2017 Jul-Sep;10(3):229-233. Epub 2017 Nov 30.
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    Diagnosis of focal disease, the theory that the human oral microbial (HOM) could affect the onset and development of systemic diseases, was very popular in the past, but the lack of scientific evidence has led to the abandonment of this idea. Interestingly, increasing evidence over the past 3 or so decades suggests that HOM can indeed serve as a reservoir for systemic dissemination of pathogenic bacteria and their toxins in distant body sites, favouring the developments of malignant tumours. Malignant tumours are complex communities of oncogenically transformed cells with aberrant genomes, associated non-neoplastic cells including immune and stromal cells, and sometimes HOM, including bacteria and viruses. Read More

    HPV infection in the oral cavity: epidemiology, clinical manifestations and relationship with oral cancer.
    Oral Implantol (Rome) 2017 Jul-Sep;10(3):209-220. Epub 2017 Nov 30.
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    Purpose: The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions.

    Materials And Methods: A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Read More

    Association Between Laryngopharyngeal Reflux and Radiation-induced Mucositis in Head and Neck Cancer.
    Anticancer Res 2018 01;38(1):477-480
    Division of Radiation Oncology, Gunma Prefectural Cancer Center, Gunma, Japan.
    Background/aim: We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis.

    Patients And Methods: This was a retrospective cohort study using our departmental database. The study included patients with stage I or II laryngeal and hypopharyngeal cancers treated with radiation therapy alone between April 2009 and March 2014. Read More

    [Expression of integrin αvβ3, CXC chemokine receptor 4 and CXC chemokine receptor 7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Dec;52(12):723-729
    Department of Head Neck and Thyroid, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, China.
    To investigate the expression of integrin αvβ3, CXC chemokine receptor (CXCR)4 and CXCR7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck (SCCHN). The expression of integrin αvβ3, CXCR4 and CXCR7 was detected by immunohistochemistry SABC in 92 cases of primary SCCHN, metastatic lymph node, normal oral mucosa tissues and normal lymph nodes. The positive rate of the expression of integrin αvβ3, CXCR4 and CXCR7 was 75% (69/92), 81%(75/92) and 76%(70/92), respectively in primary SCCHN, and was 82%(75/92), 76%(70/92) and 65%(60/92), respectively in metastatic lymph node. Read More

    Oral cancer: A multicenter study.
    Med Oral Patol Oral Cir Bucal 2018 01 1;23(1):e23-e29. Epub 2018 Jan 1.
    Department of oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand,
    Background: To determine the prevalence and clinicopathologic features of the oral cancer patients.

    Material And Methods: Biopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Read More

    [Free medial thigh perforator flaps with various pedicle origins for the reconstruction of defect after buccal mucosa squamous cell carcinoma resection].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;52(12):890-894
    Department of Oncology Plastic Surgery, Hunan Province Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410008, China.
    To explore investigate the application of free medial thigh perforator flaps with different pedicle origins in the reconstruction of defect after radical resection of buccal mucosa squamous cell carcinoma. From January 2015 to December 2016, 32 cases with buccal mucosa squamous cell carcinoma underwent radical resection and buccal mucosa defect after surgery was reconstructed by free medial thigh perforator flap at the same stage. The patients included 32 males and 5 females, ranged in age from 36 to 71 years (45. Read More

    The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for , and Species.
    Front Microbiol 2017 1;8:2391. Epub 2017 Dec 1.
    Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.
    Oral leukoplakia presents as a white patch on the oral mucosa and is recognized as having significant malignant potential. Although colonization of these patches with is common, little is known about the bacterial microbiota of these patches. In the current study we analyzed the microbiome of oral leukoplakia in 36 patients compared to healthy mucosal tissue from the same patients and healthy control subjects to determine if specific microbial enrichments could be identified early in the malignant process that could play a role in the progression of the disease. Read More

    Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis.
    Med Sci Monit 2017 Dec 14;23:5924-5932. Epub 2017 Dec 14.
    Department of Head and Neck Surgery, Sun Yan-sen University Cancer Centre, Guangzhou, Guangdong, China (mainland).
    BACKGROUND Tongue squamous cell carcinoma (TSCC) is a major type of oral cancers and has remained an intractable cancer over the past decades. The aim of this study was to identify differentially expressed genes (DEGs) during TSCC and reveal their potential mechanisms. MATERIAL AND METHODS The gene expression profiles of GSE13601 were downloaded from the GEO database. Read More

    Reconstruction after salvage laryngectomy.
    Oral Oncol 2017 Dec 21;75:22-27. Epub 2017 Oct 21.
    Department of Otolaryngology-Head and Neck Surgery, London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. Electronic address:
    Both early and advanced stage laryngeal cancers are treated with organ-preserving strategies including radiation alone or concurrent chemoradiotherapy. While organ-preserving modalities have proven effective in eradicating cancer while also preserving laryngeal function, there remains a proportion of cases where residual or recurrent cancer prevails, or conversely, where radiotherapy renders a larynx dysfunctional. In these circumstances, salvage total laryngectomy is often the surgical treatment. Read More

    Loss of epithelial markers is an early event in oral dysplasia and is observed within the safety margin of dysplastic and T1 OSCC biopsies.
    PLoS One 2017 7;12(12):e0187449. Epub 2017 Dec 7.
    Stem Cell Research Group, Manchester Dental School, Manchester, United Kingdom.
    Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer that is associated with poor 5-year patient survival. Disease treatment is further compounded by the difficulty in predicting pre-cancerous tissues that will progress to OSCC and the high recurrence rates following surgical resection. Here we have assessed expression of the oral epithelial markers E-cadherin, EMP1 and 5T4 and the pro-invasive N-cadherin proteins using fully characterised antibodies and quantitative immunofluorescence microscopy in normal tissue (NT), fibroepithelial polyp (FEP), low-grade dysplasia (LGD), high-grade dysplasia (HGD), T1 OSCC and T4 OSCC biopsies. Read More

    AHNS Series: Do you know your guidelines? Evidence-based management of oral cavity cancers.
    Head Neck 2018 Feb 5;40(2):406-416. Epub 2017 Dec 5.
    Division of Otolaryngology - Head and Neck Surgery, The George Washington University, Washington, DC.
    Oral cavity squamous cell carcinoma (OCSCC) is the most common nonmelanoma head and neck cancer in the world, with an estimated 405 000 new cases expected each year. Subsites of the oral cavity include the alveolar ridge, buccal mucosa, anterior tongue, tonsillar pillar, retromolar trigone, hard palate, gingiva, and floor of the mouth. In this issue of the AHNS "Do you know your guidelines?" series, we review the evidence-based approach to the management of oral cavity carcinomas based on the framework provided by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Read More

    Palisaded Encapsulated (Solitary Circumscribed) Neuroma of the Buccal Mucosa: a Rare Case.
    J Dent (Shiraz) 2017 Dec;18(4):314-317
    School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
    The rarity of oral soft tissue spindle cell tumors combined with overlapping microscopic patterns can make challenges in their diagnosis and treatment. Oral cavity palisaded encapsulated neuroma is an uncommon lesion which occurs often on the hard palate. It is essential for oral pathologists to be familiar with its histopathology of this lesion is essential since many lesions are probably diagnosed microscopically as neurofibroma or schwannoma. Read More

    Induction chemotherapy in locally advanced T4b oral cavity squamous cell cancers: A regional cancer center experience.
    Indian J Cancer 2017 Jan-Mar;54(1):35-38
    Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
    Objectives: The present study aimed to investigate the efficacy, toxicity, and impact of induction chemotherapy (IC) in locally advanced T4b oral cavity squamous cell cancers (OSCCs).

    Materials And Methods: Patients diagnosed with locally advanced T4b OSCC from January 2013 to October 2016 at our center, who received 2-3 cycles of IC and then assessed for resectability, were reviewed retrospectively. Patients' profile, response, and toxicity of IC, resectability status, and overall survival (OS) were evaluated. Read More

    Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury.
    Acta Pharmacol Sin 2017 Nov 30. Epub 2017 Nov 30.
    Key Lab of Drug Metabolism & Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
    Among the somatostatin analogues, octreotide (OCT) is the most commonly used in clinic via intravenous or subcutaneous injection to treat various diseases caused by increased secretion of growth hormone, gastrin or insulin. In order to assesse the feasibility of developing oral formulations of OCT, we conducted systematical pharmacokinetic and pharmacodynamic analyses of OCT in several animal models. The pharmacokinetic studies in rats showed that intragastric administration of OCT had extremely low bioavailability (<0. Read More

    Repair Index in Examination of Nuclear Changes in the Buccal Mucosa of Smokers: A Useful Method for Screening of Oral Cancer
    Asian Pac J Cancer Prev 2017 11 26;18(11):3087-3090. Epub 2017 Nov 26.
    Oral and Maxillofacial Pathology Department, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran. Email:
    Background: Smoking is one of the major risk factors for cancers, especially in the oral cavity. Nuclear changes occur in the early stages of cancer. The aim of this study was therefore to investigate nuclear changes and calculate a “repair index” for the buccal mucosa of smokers. Read More

    Longitudinal and cross-sectional assessment of quality of life in surgically treated advanced (T4) cancer of the buccal mucosa.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 21;124(6):529-536. Epub 2017 Sep 21.
    Head and Neck Oncosurgery, Tata Memorial Hospital, Mumbai, India.
    Objective: Quality of life (QOL) has become an important aspect of today's health care management. This study performed longitudinal assessment of QOL in patients with advanced cancers of the buccal mucosa (T4). We compared the QOL between patients who received adjuvant chemoradiation therapy (CTRT) and that of patients who received radiation therapy alone and assessed whether baseline QOL can predict disease recurrence. Read More

    Assessment of relationship of ABO blood groups among tobacco induced oral cancer patients of Kanpur Population, Uttar Pradesh.
    J Exp Ther Oncol 2017 Nov;12(2):129-135
    Department of Periodontics, Rama Dental College Hospital and Research Center, Kanpur, 208024, Uttar Pradesh, India.
    Background: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer.

    Materials And Method: The present study was conducted at various cancer hospitals in Kanpur. Read More

    Micronuclei assay in exfoliated buccal cells of radiation treated oral cancer patients.
    J Exp Ther Oncol 2017 Nov;12(2):121-128
    Rama Dental College Hospital and Research Centre, Department of Oral and Maxillofacial Pathology, Kanpur 208024, Uttar Pradesh, India.
    Background: Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. Evaluation of radiation-induced cellular changes to predict radiosensitivity has invested many investigators since such changes were first found in biopsy material.

    Aim: The aim of the present study was to assess the relationship of with histopathological grade and number of radiation therapy sittings with the frequency of micronuclei and nuclear anomalies among oral cancer patients. Read More

    Caspase-3 expression in tumorigenesis and prognosis of buccal mucosa squamous cell carcinoma.
    Oncotarget 2017 Oct 24;8(48):84237-84247. Epub 2017 Aug 24.
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Buccal mucosa squamous cell carcinoma (BMSCC) is the most common oral cancer in Southeast Asia. Caspase-3, a key molecule in regulating apoptosis, promotes the malignancy of various cancers. However, its role in BMSCC is unknown. Read More

    Astrocyte elevated gene-1 promotes tumour growth and invasion by inducing EMT in oral squamous cell carcinoma.
    Sci Rep 2017 Nov 13;7(1):15447. Epub 2017 Nov 13.
    Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
    Oral squamous cell carcinoma (OSCC) is a common human malignancy with a high incidence rate and poor prognosis. Although astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in carcinogenesis and tumour progression, the impact of AEG-1 on the development and progression of OSCC remains unclear. Accordingly, this study aims to clarify the biological significance of AEG-1 in OSCC. Read More

    Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target.
    Oncol Rep 2018 Jan 2;39(1):209-216. Epub 2017 Nov 2.
    Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China.
    Mesenchymal-epithelial transition factor (c-Met) is the only high affinity receptor for hepatocyte growth factor (HGF), and is frequently activated in many human cancers. However, little is known about the role of the HGF/c-Met signaling pathway in the progression of human oral squamous cell carcinoma (OSCC). This study evaluated the role of the HGF/c-Met signaling pathway in the progression of human OSCC. Read More

    Disruption of adherens junction and alterations in YAP-related proliferation behavior as part of the underlying cell transformation process of alcohol-induced oral carcinogenesis.
    Biochim Biophys Acta 2018 01 2;1865(1):209-219. Epub 2017 Nov 2.
    Division of Oral Biotechnology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. Electronic address:
    Accumulating evidences indicate that alcohol might play a causative in oral cancer. Unfortunately, in vitro cell systems, uncovering the molecular background of the underlying cell transformation process, are rare. Therefore, this study was conducted, to identify molecular changes and characterize their putative cell behavioral consequences in epitheloid (EPI) and fibroblastoid (FIB) oral keratinocyte phenotypes, arising from chronical alcohol treatment. Read More

    A systematic review of molecular responses to cancer therapy in normal human mucosa.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Oct 15;124(4):355-366. Epub 2017 Aug 15.
    Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark; Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
    Objective: Cancer therapy-induced inflammation of oral and gastrointestinal mucosae affects patients nonuniformly. Preventive strategies are limited; no biomarker exists for pretreatment identification of patients likely to be severely affected. Animal models are preferred for studying molecular responses in mucosae during chemotherapy, but translation into clinical practice is difficult. Read More

    Rare and Extensive Malignant Melanoma of the Oral Cavity: Report of Two Cases.
    J Dent (Shiraz) 2017 Sep;18(3):227-233
    Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Islamic Azad University of Isfahan (Khorasgan), Isfahan, Iran.
    Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Read More

    Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma.
    J Dent (Shiraz) 2017 Sep;18(3):207-211
    Otolaryngology Research Center, Dept. of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Statement Of The Problem: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions. Early detection of oral cancers and precancerous lesions can improve the patient's survival and decrease the morbidity.

    Purpose: This study aimed to evaluate and compare the Ki-67 and MCM3 expression in cytologic smear of oral SCC (OSCC). Read More

    Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
    J Am Acad Dermatol 2017 Nov;77(5):809-830
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    The oral cavity and cutaneous organ systems share a close embryologic origin. Therefore, there are numerous dermatologic conditions presenting with concomitant oral findings of which the dermatologist must be aware. The second article in this continuing medical education series reviews inflammatory orocutaneous conditions and a number of genodermatoses. Read More

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