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    11602 results match your criteria Cancers of the Oral Mucosa

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    Induction Chemotherapy in Technically Unresectable Locally Advanced T4a Oral Cavity Squamous Cell Cancers: Experience from a Regional Cancer Center of South India.
    Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):490-494
    Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
    Objectives: The present study aimed to investigate the efficacy, toxicity, and impact of induction chemotherapy (IC) in technically unresectable T4a oral cavity squamous cell cancers (OSCCs).

    Materials And Methods: Patients diagnosed with technically unresectable locally advanced T4a OSCC from January 2013 and November 2016 at our center, who received 2-3 cycles of IC and then assessed for resectability, were reviewed retrospectively. Patients' profile, response rates and toxicity of IC, resectability status, and overall survival (OS) were evaluated. Read More

    Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa.
    Oncoimmunology 2018 6;7(2):e1388484. Epub 2017 Nov 6.
    Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Stomatological Hospital, Sun Yat-Sen University, No. 56, Lingyuan West Road, Guangzhou, Guangdong, China.
    Curbing PD-1 immunosuppressive signaling represents an effective immune awakening or immune-reactivation approach for tumor eradication for many cancers. Yet, the potential involvement of this critical PD-1 immunosuppressive signaling in de novo malignant transformation of epithelial cells to pre-cancerous or cancerous lesions is largely unknown. In this study, we demonstrate that PD-1 signaling is critically involved in de novo malignant transformation of oral mucosa upon carcinogen exposure in vivo. Read More

    Local Acetaldehyde-An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis.
    Cancers (Basel) 2018 Jan 5;10(1). Epub 2018 Jan 5.
    Research Unit on Acetaldehyde and Cancer, University of Helsinki, Biomedicum Helsinki P.O. Box 63, 00014 Helsinki, Finland.
    The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a significant risk factor for oral and esophageal carcinogenesis and is characterized by a dysbiotic microbiome. Dysbiosis leads to increased growth of opportunistic pathogens (such as Candida yeasts) and may cause an up to 100% increase in the local ACH production, which is further modified by organ-specific expression and gene polymorphisms of ethanol-metabolizing and ACH-metabolizing enzymes. Read More

    Focus on periodontal disease and colorectal carcinoma.
    Oral Implantol (Rome) 2017 Jul-Sep;10(3):229-233. Epub 2017 Nov 30.
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    Diagnosis of focal disease, the theory that the human oral microbial (HOM) could affect the onset and development of systemic diseases, was very popular in the past, but the lack of scientific evidence has led to the abandonment of this idea. Interestingly, increasing evidence over the past 3 or so decades suggests that HOM can indeed serve as a reservoir for systemic dissemination of pathogenic bacteria and their toxins in distant body sites, favouring the developments of malignant tumours. Malignant tumours are complex communities of oncogenically transformed cells with aberrant genomes, associated non-neoplastic cells including immune and stromal cells, and sometimes HOM, including bacteria and viruses. Read More

    HPV infection in the oral cavity: epidemiology, clinical manifestations and relationship with oral cancer.
    Oral Implantol (Rome) 2017 Jul-Sep;10(3):209-220. Epub 2017 Nov 30.
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    Purpose: The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions.

    Materials And Methods: A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Read More

    Association Between Laryngopharyngeal Reflux and Radiation-induced Mucositis in Head and Neck Cancer.
    Anticancer Res 2018 01;38(1):477-480
    Division of Radiation Oncology, Gunma Prefectural Cancer Center, Gunma, Japan.
    Background/aim: We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis.

    Patients And Methods: This was a retrospective cohort study using our departmental database. The study included patients with stage I or II laryngeal and hypopharyngeal cancers treated with radiation therapy alone between April 2009 and March 2014. Read More

    [Expression of integrin αvβ3, CXC chemokine receptor 4 and CXC chemokine receptor 7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck].
    Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Dec;52(12):723-729
    Department of Head Neck and Thyroid, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, China.
    Objective: To investigate the expression of integrin αvβ3, CXC chemokine receptor (CXCR)4 and CXCR7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck (SCCHN). Methods: The expression of integrin αvβ3, CXCR4 and CXCR7 was detected by immunohistochemistry SABC in 92 cases of primary SCCHN, metastatic lymph node, normal oral mucosa tissues and normal lymph nodes. Results: The positive rate of the expression of integrin αvβ3, CXCR4 and CXCR7 was 75% (69/92), 81%(75/92) and 76%(70/92), respectively in primary SCCHN, and was 82%(75/92), 76%(70/92) and 65%(60/92), respectively in metastatic lymph node. Read More

    Oral cancer: A multicenter study.
    Med Oral Patol Oral Cir Bucal 2018 01 1;23(1):e23-e29. Epub 2018 Jan 1.
    Department of oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand,
    Background: To determine the prevalence and clinicopathologic features of the oral cancer patients.

    Material And Methods: Biopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Read More

    [Free medial thigh perforator flaps with various pedicle origins for the reconstruction of defect after buccal mucosa squamous cell carcinoma resection].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;52(12):890-894
    Department of Oncology Plastic Surgery, Hunan Province Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410008, China.
    Objective: To explore investigate the application of free medial thigh perforator flaps with different pedicle origins in the reconstruction of defect after radical resection of buccal mucosa squamous cell carcinoma. Methods: From January 2015 to December 2016, 32 cases with buccal mucosa squamous cell carcinoma underwent radical resection and buccal mucosa defect after surgery was reconstructed by free medial thigh perforator flap at the same stage. The patients included 32 males and 5 females, ranged in age from 36 to 71 years (45. Read More

    The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia Species.
    Front Microbiol 2017 1;8:2391. Epub 2017 Dec 1.
    Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.
    Oral leukoplakia presents as a white patch on the oral mucosa and is recognized as having significant malignant potential. Although colonization of these patches with Candida albicans is common, little is known about the bacterial microbiota of these patches. In the current study we analyzed the microbiome of oral leukoplakia in 36 patients compared to healthy mucosal tissue from the same patients and healthy control subjects to determine if specific microbial enrichments could be identified early in the malignant process that could play a role in the progression of the disease. Read More

    Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis.
    Med Sci Monit 2017 Dec 14;23:5924-5932. Epub 2017 Dec 14.
    Department of Head and Neck Surgery, Sun Yan-sen University Cancer Centre, Guangzhou, Guangdong, China (mainland).
    BACKGROUND Tongue squamous cell carcinoma (TSCC) is a major type of oral cancers and has remained an intractable cancer over the past decades. The aim of this study was to identify differentially expressed genes (DEGs) during TSCC and reveal their potential mechanisms. MATERIAL AND METHODS The gene expression profiles of GSE13601 were downloaded from the GEO database. Read More

    Reconstruction after salvage laryngectomy.
    Oral Oncol 2017 Dec 21;75:22-27. Epub 2017 Oct 21.
    Department of Otolaryngology-Head and Neck Surgery, London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. Electronic address:
    Both early and advanced stage laryngeal cancers are treated with organ-preserving strategies including radiation alone or concurrent chemoradiotherapy. While organ-preserving modalities have proven effective in eradicating cancer while also preserving laryngeal function, there remains a proportion of cases where residual or recurrent cancer prevails, or conversely, where radiotherapy renders a larynx dysfunctional. In these circumstances, salvage total laryngectomy is often the surgical treatment. Read More

    Loss of epithelial markers is an early event in oral dysplasia and is observed within the safety margin of dysplastic and T1 OSCC biopsies.
    PLoS One 2017 7;12(12):e0187449. Epub 2017 Dec 7.
    Stem Cell Research Group, Manchester Dental School, Manchester, United Kingdom.
    Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer that is associated with poor 5-year patient survival. Disease treatment is further compounded by the difficulty in predicting pre-cancerous tissues that will progress to OSCC and the high recurrence rates following surgical resection. Here we have assessed expression of the oral epithelial markers E-cadherin, EMP1 and 5T4 and the pro-invasive N-cadherin proteins using fully characterised antibodies and quantitative immunofluorescence microscopy in normal tissue (NT), fibroepithelial polyp (FEP), low-grade dysplasia (LGD), high-grade dysplasia (HGD), T1 OSCC and T4 OSCC biopsies. Read More

    AHNS Series: Do you know your guidelines? Evidence-based management of oral cavity cancers.
    Head Neck 2018 Feb 5;40(2):406-416. Epub 2017 Dec 5.
    Division of Otolaryngology - Head and Neck Surgery, The George Washington University, Washington, DC.
    Oral cavity squamous cell carcinoma (OCSCC) is the most common nonmelanoma head and neck cancer in the world, with an estimated 405 000 new cases expected each year. Subsites of the oral cavity include the alveolar ridge, buccal mucosa, anterior tongue, tonsillar pillar, retromolar trigone, hard palate, gingiva, and floor of the mouth. In this issue of the AHNS "Do you know your guidelines?" series, we review the evidence-based approach to the management of oral cavity carcinomas based on the framework provided by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Read More

    Palisaded Encapsulated (Solitary Circumscribed) Neuroma of the Buccal Mucosa: a Rare Case.
    J Dent (Shiraz) 2017 Dec;18(4):314-317
    School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
    The rarity of oral soft tissue spindle cell tumors combined with overlapping microscopic patterns can make challenges in their diagnosis and treatment. Oral cavity palisaded encapsulated neuroma is an uncommon lesion which occurs often on the hard palate. It is essential for oral pathologists to be familiar with its histopathology of this lesion is essential since many lesions are probably diagnosed microscopically as neurofibroma or schwannoma. Read More

    Induction chemotherapy in locally advanced T4b oral cavity squamous cell cancers: A regional cancer center experience.
    Indian J Cancer 2017 Jan-Mar;54(1):35-38
    Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
    Objectives: The present study aimed to investigate the efficacy, toxicity, and impact of induction chemotherapy (IC) in locally advanced T4b oral cavity squamous cell cancers (OSCCs).

    Materials And Methods: Patients diagnosed with locally advanced T4b OSCC from January 2013 to October 2016 at our center, who received 2-3 cycles of IC and then assessed for resectability, were reviewed retrospectively. Patients' profile, response, and toxicity of IC, resectability status, and overall survival (OS) were evaluated. Read More

    Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury.
    Acta Pharmacol Sin 2017 Nov 30. Epub 2017 Nov 30.
    Key Lab of Drug Metabolism & Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
    Among the somatostatin analogues, octreotide (OCT) is the most commonly used in clinic via intravenous or subcutaneous injection to treat various diseases caused by increased secretion of growth hormone, gastrin or insulin. In order to assesse the feasibility of developing oral formulations of OCT, we conducted systematical pharmacokinetic and pharmacodynamic analyses of OCT in several animal models. The pharmacokinetic studies in rats showed that intragastric administration of OCT had extremely low bioavailability (<0. Read More

    Repair Index in Examination of Nuclear Changes in the Buccal Mucosa of Smokers: A Useful Method for Screening of Oral Cancer
    Asian Pac J Cancer Prev 2017 11 26;18(11):3087-3090. Epub 2017 Nov 26.
    Oral and Maxillofacial Pathology Department, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran. Email:
    Background: Smoking is one of the major risk factors for cancers, especially in the oral cavity. Nuclear changes occur in the early stages of cancer. The aim of this study was therefore to investigate nuclear changes and calculate a “repair index” for the buccal mucosa of smokers. Read More

    Longitudinal and cross-sectional assessment of quality of life in surgically treated advanced (T4) cancer of the buccal mucosa.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 21;124(6):529-536. Epub 2017 Sep 21.
    Head and Neck Oncosurgery, Tata Memorial Hospital, Mumbai, India.
    Objective: Quality of life (QOL) has become an important aspect of today's health care management. This study performed longitudinal assessment of QOL in patients with advanced cancers of the buccal mucosa (T4). We compared the QOL between patients who received adjuvant chemoradiation therapy (CTRT) and that of patients who received radiation therapy alone and assessed whether baseline QOL can predict disease recurrence. Read More

    Assessment of relationship of ABO blood groups among tobacco induced oral cancer patients of Kanpur Population, Uttar Pradesh.
    J Exp Ther Oncol 2017 Nov;12(2):129-135
    Department of Periodontics, Rama Dental College Hospital and Research Center, Kanpur, 208024, Uttar Pradesh, India.
    Background: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer.

    Materials And Method: The present study was conducted at various cancer hospitals in Kanpur. Read More

    Caspase-3 expression in tumorigenesis and prognosis of buccal mucosa squamous cell carcinoma.
    Oncotarget 2017 Oct 24;8(48):84237-84247. Epub 2017 Aug 24.
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Buccal mucosa squamous cell carcinoma (BMSCC) is the most common oral cancer in Southeast Asia. Caspase-3, a key molecule in regulating apoptosis, promotes the malignancy of various cancers. However, its role in BMSCC is unknown. Read More

    Astrocyte elevated gene-1 promotes tumour growth and invasion by inducing EMT in oral squamous cell carcinoma.
    Sci Rep 2017 Nov 13;7(1):15447. Epub 2017 Nov 13.
    Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
    Oral squamous cell carcinoma (OSCC) is a common human malignancy with a high incidence rate and poor prognosis. Although astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in carcinogenesis and tumour progression, the impact of AEG-1 on the development and progression of OSCC remains unclear. Accordingly, this study aims to clarify the biological significance of AEG-1 in OSCC. Read More

    Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target.
    Oncol Rep 2018 Jan 2;39(1):209-216. Epub 2017 Nov 2.
    Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China.
    Mesenchymal-epithelial transition factor (c-Met) is the only high affinity receptor for hepatocyte growth factor (HGF), and is frequently activated in many human cancers. However, little is known about the role of the HGF/c-Met signaling pathway in the progression of human oral squamous cell carcinoma (OSCC). This study evaluated the role of the HGF/c-Met signaling pathway in the progression of human OSCC. Read More

    Rare and Extensive Malignant Melanoma of the Oral Cavity: Report of Two Cases.
    J Dent (Shiraz) 2017 Sep;18(3):227-233
    Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Islamic Azad University of Isfahan (Khorasgan), Isfahan, Iran.
    Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Read More

    Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma.
    J Dent (Shiraz) 2017 Sep;18(3):207-211
    Otolaryngology Research Center, Dept. of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Statement Of The Problem: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions. Early detection of oral cancers and precancerous lesions can improve the patient's survival and decrease the morbidity.

    Purpose: This study aimed to evaluate and compare the Ki-67 and MCM3 expression in cytologic smear of oral SCC (OSCC). Read More

    Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
    J Am Acad Dermatol 2017 Nov;77(5):809-830
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    The oral cavity and cutaneous organ systems share a close embryologic origin. Therefore, there are numerous dermatologic conditions presenting with concomitant oral findings of which the dermatologist must be aware. The second article in this continuing medical education series reviews inflammatory orocutaneous conditions and a number of genodermatoses. Read More

    Molecular characterization, prevalence and clinical relevance of Phodopus sungorus papillomavirus type 1 (PsuPV1) naturally infecting Siberian hamsters (Phodopus sungorus).
    J Gen Virol 2017 Nov 12;98(11):2799-2809. Epub 2017 Oct 12.
    1​Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
    Phodopus sungorus papillomavirus type 1 (PsuPV1), naturally infecting Siberian hamsters (Phodopus sungorus) and clustering in the genus Pipapillomavirus (Pi-PV), is only the second PV type isolated from the subfamily of hamsters. In silico analysis of three independent complete viral genomes obtained from cervical adenocarcinoma, oral squamous cell carcinoma and normal oral mucosa revealed that PsuPV1 encodes characteristic viral proteins (E1, E2, E4, E6, E7, L1 and L2) with conserved functional domains and a highly conserved non-coding region. The overall high prevalence (102/114; 89. Read More

    Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms.
    Tumour Biol 2017 Oct;39(10):1010428317728683
    1 Esophageal and Digestive Tract Surgical Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
    Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal microenvironment of esophageal adenocarcinoma. Therefore, A prospective cohort of consecutive patients undergoing esophagectomy for esophageal adenocarcinoma was enrolled. Read More

    Do Dental X-Rays Induce Genotoxicity and Cytotoxicity in Oral Mucosa Cells? A Critical Review.
    Anticancer Res 2017 10;37(10):5383-5388
    Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Sao Paulo, Brazil
    Dental X-rays are widely used in clinical practice, since the technique is an important approach for diagnosing diseases in dental and periodontal tissues. However, it is widely known that radiation is capable of causing damage to cellular systems, such as genotoxicity or cytotoxicity. Thus, the aim of this review was to present a critical analysis regarding the studies published on genotoxicity and cytotoxicity induced by dental X-rays in oral mucosa cells. Read More

    Role of Cathepsin B as a Marker of Malignant Transformation in Oral Lichen Planus: An Immunohistochemical Study.
    J Clin Diagn Res 2017 Aug 1;11(8):ZC29-ZC32. Epub 2017 Aug 1.
    Reader, Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
    Introduction: Malignant transformation of Oral Lichen Planus (OLP) remains a much discussed but very less understood realm. Various hypotheses and theories have been put forward to explain the same. Malignant transformation is a complex interplay of epithelial mesenchymal factors acting in tandem. Read More

    The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra - a retrospective 10-year study.
    Contemp Oncol (Pozn) 2017 30;21(2):178-183. Epub 2017 Jun 30.
    Rural Dental College, Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
    Aim Of The Study: Oral cancer ranks in the top three of all cancers in India and is quickly becoming a global health priority. More than 90% of oral and oropharyngeal cancers are squamous cell carcinoma. The purpose of this study was to document its incidence depending upon the involvement of different sites of oral cavity, and its variation with age and gender. Read More

    Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment.
    Contemp Oncol (Pozn) 2017 30;21(2):145-151. Epub 2017 Jun 30.
    King George's Medical University, India.
    Aim Of The Study: Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research.

    Material And Methods: Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). Read More

    Importance of Early Detection of Potentially Malignant Lesions in the Prevention of Oral Cancer.
    Mater Sociomed 2017 Jun;29(2):129-133
    Maxillofacial surgery Clinical Center of Sarajevo, Bosnia and Hercegovina.
    Objective: The aim of this study was to assess the importance of early diagnosis of potentially malignant lesions in the prevention of oral cancer.

    Material And Methods: In order to achieve the set objectives, we selected our participant pool. Of the 340 patients who came to the initial examination at the Clinic for Oral Medicine and Periodontology, we selected 40 patients with potentially malignant oral lesions (PMOL) of both sexes and of different ages. Read More

    DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs.
    PLoS One 2017 6;12(9):e0184425. Epub 2017 Sep 6.
    Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy.
    The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic DNA copy number aberrations (CNAs) in oral potentially malignant disorder (OPMD) and oral squamous cell carcinoma (OSCC) patients. DNA aneuploidy was detected by high-resolution DNA flow cytometry (hr DNA-FCM) on DAPI stained nuclei obtained from multiple tissue samples from OPMDs/OSCCs in 220 consecutive patients. Nuclear genomic aberrations were determined in a subset of 65 patients by genome-wide array comparative genomic hybridization (aCGH) using DNA extracted from either diploid or aneuploid nuclei suspension sorted by FCM. Read More

    HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features.
    Am J Surg Pathol 2017 Dec;41(12):1690-1701
    *Departments of Pathology, Oncology, and Otolaryngology-Head and Neck Surgery, The Johns Hopkins University, Baltimore, MD †Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX Departments of ‡Otorhinolaryngology Head & Neck Surgery and Audiology ¶¶¶Pathology, Copenhagen University Hospital, Copenhagen §Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark ∥Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital ¶School of Medicine, National Yang-Ming University, Taipei, Taiwan #Department of Pathology, Dalhousie University, Halifax, NS, Canada **Mayo Clinic School of Medicine, Mayo Clinic ‡‡Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN ††Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy §§Department of Pathology, Warren Alpert School of Medicine at Brown University (retired), Providence, RI ∥∥Department of Pathology, University of Miami, Miami, FL ¶¶Laboratory for Dermatohistology and Oral Pathology, Munich, Germany ##Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN ***Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA †††Department of Pathology, Loyola University Medical Center, Chicago, IL ‡‡‡Department of Pathology, Imperial College, London, United Kingdom §§§Department of Pathology, University of Toulouse, Toulouse, France ∥∥∥Department of Pathology, University of Virginia, Charlottesville, VA.
    Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a peculiar neoplasm that is restricted to the sinonasal tract, exhibits features of both a surface-derived and salivary gland carcinoma (particularly adenoid cystic carcinoma), and is associated with high-risk HPV. Given the limited number of published cases, the full clinicopathologic spectrum of this neoplasm is unclear. Here, we present an updated experience of 49 cases. Read More

    Plunging Ranula Occurring Without its Oral Counterpart: A Case Report.
    J Clin Pediatr Dent 2017;41(5):381-383
    A ranula is a lesion that arises from mucin spillage from the sublingual or submandibular gland ducts, beneath the mucosa of the oral floor. A plunging or cervical ranula dissects the mylohyoid muscle and appears as a submandibular swelling. Rarely, a plunging ranula is encountered without its oral counterpart. Read More

    Prophylactic immunization with human papillomavirus vaccines induces oral immunity in mice.
    Laryngoscope 2018 Jan 4;128(1):E16-E20. Epub 2017 Sep 4.
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, U.S.A.
    Objective: Although it has been shown that prophylactic vaccination can induce genital immunity, there is inadequate information on human papillomavirus (HPV) vaccine-induced oral immunity, which is of particular interest due to HPV-associated oropharyngeal malignancies and recurrent respiratory papillomatosis. Therefore, we assessed the efficacy of various HPV vaccines against oral HPV pseudovirus (PsV) infection in mice.

    Study Design: Preclinical scientific investigation. Read More

    Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor.
    J Cancer Res Ther 2017 Jul-Sep;13(3):430-435
    Department of Obstetrics and Gynecology, J.N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
    Background: Head and neck cancers (HNCs) are a major form of cancers in India. The spectrum varies from place to place within the country because of significant diversified risk factors.

    Aims And Objective: To study, epidemiology and risk factors of HNC patients from Western Uttar Pradesh and to find out the correlation between risk factors and different anatomical regions involved. Read More

    Oral and maxillofacial non-Hodgkin lymphomas: Case report with review of literature.
    Medicine (Baltimore) 2017 Sep;96(35):e7890
    aDepartment of Head Neck Surgery, Hainan Cancer Hospital, Haikou, Hainan bDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Lymphomas take up about 14% of all head-neck malignancies, out of which 97% are non-Hodgkin lymphomas (NHL). The clinical courses, treatment responses, and prognoses of NHLs vary with different subtypes and anatomic sites. In the Chinese population (including the Taiwanese), head-neck NHLs are often seen with the tonsils, nasal cavity, nasal sinus, and the nasopharynx. Read More

    Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats.
    Cell Physiol Biochem 2017 18;42(6):2330-2341. Epub 2017 Aug 18.
    Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
    Background/aims: Intestinal mucositis (IM) is a commonly encountered side effect in cancer patients receiving chemotherapy. This study aimed to investigate the effect of Bifidobacterium infantis (B. infantis) in attenuating the severity of chemotherapy-induced intestinal mucositis by regulating the T cell subsets in rats with colorectal cancer (CRC). Read More

    [Intensity Modulated Hyperfractionated Accelerated Radiotherapy to Treat Advanced Head and Neck Cancer - Predictive Factors of Overall Survival].
    Klin Onkol 2017 ;30(4):282-288
    Aim: The aim of this study was to evaluate overall survival (OS) and prognostic factors in patients ineligible for chemotherapy who were treated with a hyperfractionated accelerated schedule with simultaneous integrated boost.

    Material And Methods: From May, 2008, to April, 2013, 122 patients with locally advanced nonmetastatic squamous laryngeal (14%), hypopharyngeal (30%), oropharyngeal (30%), and oral cavity (27%) cancer were treated at our institution. The median age, Karnofsky Performance Status (KPS), and gross tumor volume (GTV) of the patients were 63 years (range, 46-87 years), 80% (range, 50-100%), and 46 ml (range, 5-250 ml), resp. Read More

    α-Bisabolol improves 5-aminolevulinic acid retention in buccal tissues: Potential application in the photodynamic therapy of oral cancer.
    J Photochem Photobiol B 2017 Sep 8;174:298-305. Epub 2017 Aug 8.
    School of Pharmacy, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, 21941-902 Rio de Janeiro, RJ, Brazil. Electronic address:
    Context: 5-Aminolevulinic acid (5-ALA) is a prodrug used in photodynamic therapy (PDT) of tumors, including cancer of the oral mucosa. 5-ALA poorly penetrates oral tissues due to its high hydrophilicity, which impairs its local effects in PDT.

    Objectives: To examine whether α-bisabolol (α-Bis) influences the 5-ALA permeability in the porcine buccal mucosa, to an extent that improves its application in PDT (which requires low permeation and high retention in the buccal mucosa). Read More

    Cytological Changes in Normal Oral Mucosa of Individuals with Tobacco Habits: A Cytomorphometric Study.
    J Contemp Dent Pract 2017 Aug 1;18(8):722-727. Epub 2017 Aug 1.
    Department of Oral Pathology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India.
    Introduction: Oral cancer is one of the six most common cancers in the world, and globally more than 50% of head and neck cancers occur in Asia, remarkably in India. Overall, 200,000 cases of head and neck cancers occur each year in India, among which 80,000 are oral cancers. Epidemiological and clinical studies suggest a causative role of tobacco use in the evolution of oral potentially malignant and malignant disorders. Read More

    The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients.
    Adv Clin Exp Med 2017 May-Jun;26(3):409-413
    Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, China.
    Background: Acute oral mucositis is a common complication of radiotherapy for nasopharyngeal carcinoma (NPC) patients.

    Objectives: The aim of the study was to observe the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on radiotherapy-induced oral mucositis in locally advanced NPC patients.

    Material And Methods: The study involved 64 locally advanced NPC patients that were randomly allocated to receive either rhG-CSF mouthwash (2 μg/mL rhG-CSF; group A, n = 34) or a compounded mouth rinse (10 μg/mL vitamin B12, 0. Read More

    Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions.
    Expert Opin Drug Metab Toxicol 2017 Sep 10;13(9):953-972. Epub 2017 Aug 10.
    a Faculty of Pharmacy , The University of Sydney , Sydney , Australia.
    Introduction: Curcumin has been extensively studied for its anti-cancer properties. While a diverse array of in vitro and preclinical research support the prospect of curcumin use as an anti-cancer therapeutic, most human studies have failed to meet the intended clinical expectation. Poor systemic availability of orally-administered curcumin may account for this disparity. Read More

    Squamous cell carcinoma of the buccal mucosa involving the masticator space: a case report.
    J Korean Assoc Oral Maxillofac Surg 2017 Jun 28;43(3):191-196. Epub 2017 Jun 28.
    Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Korea.
    Squamous cell carcinoma of the buccal mucosa has an aggressive nature, as it grows rapidly and penetrates well with a high recurrence rate. If cancers originating from the buccal mucosa invade adjacent anatomical structures, surgical tumor resection becomes more challenging, thus raising specific considerations for reconstruction relative to the extent of resection. The present case describes the surgical management of a 58-year-old man who presented with persistent ulceration of the mucosal membrane and a mouth-opening limitation of 11 mm. Read More

    The methylation status and expression of human telomerase reverse transcriptase is significantly high in oral carcinogenesis.
    APMIS 2017 Sep 2;125(9):797-807. Epub 2017 Aug 2.
    Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Kitakyushu, Japan.
    Telomerase activity is present in most cancers and is tightly regulated by the expression of human telomerase reverse transcriptase (hTERT). Hypermethylation in the promoter region of hTERT contributes to the regulation of hTERT expression. In this study, we investigated the methylation and expression of hTERT in oral squamous cell carcinoma (OSCC), oral leukoplakia, and normal oral mucosa. Read More

    The color of cancer: Margin guidance for oral cancer resection using elastic scattering spectroscopy.
    Laryngoscope 2017 Sep 28;127 Suppl 4:S1-S9. Epub 2017 Jul 28.
    Department of Biomedical Engineering, Boston University College of Engineering, Boston, Massachusetts, U.S.A.
    Objectives/hypothesis: To evaluate the usefulness of elastic scattering spectroscopy (ESS) as a diagnostic adjunct to frozen section analysis in patients with diagnosed squamous cell carcinoma of the oral cavity.

    Study Design: Prospective analytic study.

    Methods: Subjects for this single institution, institutional review board-approved study were recruited from among patients undergoing surgical resection for squamous cell cancer of the oral cavity. Read More

    ORONASAL SQUAMOUS CELL CARCINOMAS IN FRANÇOIS' LANGURS (TRACHYPITHECUS FRANCOISI).
    J Zoo Wildl Med 2017 Jun;48(2):394-403
    Squamous cell carcinomas (SCCs) are common oronasal tumors in nonhuman primates. In this study, 11 cases of oronasal SCC in François' langurs ( Trachypithecus francoisi ) are described. Five initial cases were discovered on review of the North American François' langur studbook, with a potential familial pattern observed. Read More

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