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    11380 results match your criteria Cancers of the Oral Mucosa

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    [Immunohistochemical criteria for differential diagnostics of squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa].
    Stomatologiia (Mosk) 2017 ;96(2):33-35
    Peoples' Friendship University of Russia, Moscow, Russia.
    The paper presents an example of differential diagnostic studies for pyogenic granuloma and oral squamous cell carcinoma (SCC). In the described case immunohistochemistry with antibodies to Ki-67 and Gli1 was used as conventional histological procedure proved to be inconvenient for adequate diagnostics. The immunohistochemical study established increased proliferative activity of epithelial cells specific both pyogenic granuloma and oral SCC, but intensive Gli1 protein expression in membranes and cytoplasm of epithelial cells with malignant transformation allowed differentiation of these neoplasms. Read More

    Mouth examination performance by children's parents and by adolescents in Fanconi anemia.
    Pediatr Blood Cancer 2017 May 13. Epub 2017 May 13.
    Department of Stomatology, Post Graduate Program in Dentistry, Federal University of Paraná School of Dentistry, Curitiba, Paraná, Brazil.
    Background: Fanconi anemia (FA) is a rare genetic syndrome characterized by increased risk of developing malignant neoplasms, particularly oral squamous cell carcinoma. This study aims to ascertain the extent to which adolescents and guardians/parents of children with FA are aware of their oral cancer risks and assess their ability to perform mouth examination (ME).

    Procedure: A cross-sectional study was conducted among patients with FA (between 6 and 16 years) and their parents. Read More

    Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.
    Cold Spring Harb Mol Case Stud 2017 May;3(3):a001610
    Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
    Colon polyps represent precursor lesions of colon cancers and their malignant potential varies according to histological subtype. A rare subtype of colon polyps is the Peutz-Jeghers (PJ) polyp. PJ polyps mostly occur in the context of Peutz-Jeghers syndrome, which is characterized by the development of multiple polyps in the intestinal tract and hyperpigmentation of oral mucosa and lips. Read More

    Hematopoietic neoplasms accompanied by severe enterocolitis due to Aeromonas species.
    Rinsho Ketsueki 2017 ;58(4):303-308
    Department of Hematology, Tokushima Prefectural Central Hospital.
    Aeromonas species are known to be a cause of diarrhea and acute enterocolitis. However, only a few cases have been reported and the pathophysiology of Aeromonas infection has not as yet been clarified. We experienced 2 cases developing severe enterocolitis during the course of hematological malignancies, specifically multiple myeloma and diffuse large B-cell lymphoma. Read More

    Benign reactive lymphadenopathy associated with submandibular gland enlargement during orthodontic treatment.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):181
    Department of Oral Pathology, Army College of Dental Sciences, Secunderabad, Telangana, India.
    Lymphadenopathy may be caused due to various reasons, most common being infections, neoplasms and immunologic disorders. Considering the frequent use of biomaterials in dentistry, it is not uncommon to find allergic reactions in the oral mucosa. Delayed-type hypersensitivity is one mechanism of allergy, which may manifest as either contact stomatitis or rarely present as only lymphadenopathy. Read More

    Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions.
    Oral Oncol 2017 May 18;68:36-43. Epub 2017 Mar 18.
    Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
    Objectives: Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transformation of oral precancerous lesions.

    Materials And Methods: Patients with oral precancerous lesions managed at the Nara Medical University Hospital, Japan, (n=120) were enrolled in this study. Read More

    The role of mast cells in oral squamous cell carcinoma.
    Contemp Oncol (Pozn) 2017 22;21(1):21-29. Epub 2017 Mar 22.
    Department of Oral Pathology and Microbiology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
    The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Read More

    Congenital amelanotic melanoma in a crossbred heifer calf.
    J Vet Diagn Invest 2017 Apr 1:1040638717706399. Epub 2017 Apr 1.
    Departments of Veterinary Clinical Sciences (Winslow, Gilliam), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.
    A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis. Read More

    Oral pigmentations in physiologic conditions, post inflammatory affections and systemic diseases.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
    Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Read More

    Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.
    Tumour Biol 2017 Apr;39(4):1010428317695930
    1 The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, People's Republic of China.
    Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor necrosis factor receptor-associated factor 1 with cancer stem cell markers in oral squamous cell carcinoma. This study aimed to investigate the expression of tumor necrosis factor receptor-associated factor 1 and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral squamous cell carcinoma and analyze their relations. Read More

    HPV disease transmission protection and control.
    Microb Cell 2016 Sep 5;3(9):476-490. Epub 2016 Sep 5.
    The Jake Gittlen Laboratories for Cancer Research, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
    Human papillomaviruses (HPVs) represent a large collection of viral types associated with significant clinical disease of cutaneous and mucosal epithelium. HPV-associated cancers are found in anogenital and oral mucosa, and at various cutaneous sites. Papillomaviruses are highly species and tissue restricted, and these viruses display both mucosotropic, cutaneotropic or dual tropism for epithelial tissues. Read More

    Effect of Tempol on the prevention of irradiation-induced mucositis in miniature pigs.
    Oral Dis 2017 Mar 22. Epub 2017 Mar 22.
    Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
    Objective: The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation-induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development.

    Methods And Materials: Minipigs were irradiated with 6 Gy for five consecutive days targeting the entire oral cavity. To prevent radiation damage, minipigs were treated with 30 mg kg(-1) Tempol 10 min before irradiation (n = 4), while the radiation-alone group was similarly injected with saline (n = 4). Read More

    Mucosal melanoma of the head and neck.
    Crit Rev Oncol Hematol 2017 Apr 13;112:136-152. Epub 2017 Feb 13.
    Department Melanoma, Soft Tissues, Musculoskeletal and Head & Neck, Italian National Cancer Institute - IRCCS Pascale Foundation, Naples, Italy.
    Mucosal melanoma of the head and neck is a very rare and aggressive malignancy with a very poor prognosis. The nasal cavity, paranasal sinuses, and oral cavity are the most common locations. One-, 3- and 5-year survival rates between 2000 and 2007 were 63%, 30% and 20%, respectively. Read More

    Giant oral lipoma: a rare entity.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):84-86
    Bauru Dental School - University of São Paulo (USP) - Bauru (SP), Brazil.
    Lipomas are very common benign slow-growing soft tissue neoplasms composed of mature adipose tissue mostly diagnosed in the fifth decade of life. These tumors rarely present in the oral cavity, representing less than approximately 5% of all benign mouth tumors. They are usually less than 2cm in size and etiology remains unclear. Read More

    Crossed pectoralis major myocutaneous flap for recurrent oral cavity cancers.
    Ann Maxillofac Surg 2016 Jul-Dec;6(2):219-222
    Department of Surgical Oncology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.
    Background: Oral cavity cancers are fairly common and have propensity to recur locally. Since Pectoralis Major Myocutaneous (PMMC) flap is the most widely used first flap for reconstruction, it is exhausted at the earliest and recurrence poses a formidable challenge for reconstructive surgeon. Present study evaluated the feasibility of contralateral Pectoralis Major Myocutaneous Flap for reconstruction after resection of recurrent tumour. Read More

    Oral and Maxillofacial Lesions Diagnosed in Older People of a Brazilian Population: A Multicentric Study.
    J Am Geriatr Soc 2017 Mar 13. Epub 2017 Mar 13.
    Postgraduate Program in Oral Pathology, UFRN, Natal, Brazil.
    Objectives: The aim of this study was to investigate the prevalence of oral and maxillofacial lesions among older adults (≥60 years) from representative regions in Brazil.

    Design: Retrospective descriptive cross-sectional study.

    Setting: Biopsy records were obtained from the archives of four Brazilian referral centers of oral diagnosis between 2000 and 2016. Read More

    Role of MRI in Evaluation of Malignant Lesions of Tongue and Oral Cavity.
    Pol J Radiol 2017 16;82:92-99. Epub 2017 Feb 16.
    Department of Radiodiagnosis, Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India.
    Background: Aim of the present study was to evaluate the role of MRI in staging of malignant lesions of the oral cavity and to correlate MRI findings with clinical/surgical and anatomical-pathological findings, wherever possible.

    Material/methods: The study included 50 patients who presented with malignant lesions of the oral cavity and were referred to radiology departments for MRI. All patients included were subjected to a detailed physical examination following which MRI was carried out on Philips Gyroscan Achieva 1. Read More

    The Possible Role of Diabetes in the Etiology of Laryngeal Cancer.
    Gulf J Oncolog 2017 Jan;1(23):44-51
    IRSS Policlinico San Donato, University of Milan, Italy.
    Background: Laryngeal cancer and oral cancer are not always correlated with genetic mutations, HPV infection, smoking, and alcohol abuse. In the absence of these risk factors, there is an increase on these cancers with a parallel increase of diabetes. The aim of this study is to verify if diabetes could be a risk factor for the laryngeal cancer. Read More

    Squamous cell carcinoma of the oral cavity and oropharynx in young adults.
    Indian J Cancer 2016 Jul-Sep;53(3):399-401
    Department of Radiation Oncology, VMMC and Safdarjung Hospital, New Delhi, India.
    Background: Head and neck squamous cell carcinoma (SCC) is a disease of older age group predominately in the sixth and eighth decades of life. The incidence of oral SCC (young age <40 years) varies between 0.4% and 3. Read More

    Skin involvement and ipsilateral nodal metastasis as a predictor of contralateral nodal metastasis in buccal mucosa cancers.
    Indian J Cancer 2016 Jul-Sep;53(3):394-396
    Department of Head and Neck Services, Tata Memorial Hospital, Mumbai, Maharashtra, India.
    Context: In view of low incidence of contralateral nodal metastasis and increase in the morbidity, the opposite neck is not routinely addressed. However, contralateral nodal metastasis is seen frequently in a certain group of patients. Identifying those factors associated with higher chances of contralateral nodal metastasis may help in optimizing the treatment. Read More

    Oral Cancer Early Detection: What Do Patients Need To Know?
    J Cancer Educ 2017 Feb 20. Epub 2017 Feb 20.
    University College London, London, UK.
    The purpose of the present study was to examine the educational needs of patients regarding early detection of oral cancer. A total of 790 patients without cancer were interviewed and shown a set of validated clinical images of various oral lesions including early oral cancer. Participants were asked about their perception of cancer and the action that they would take if they notice a similar lesion. Read More

    Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo.
    World J Gastroenterol 2017 Jan;23(4):603-613
    You Lv, Tao Ye, Hui-Peng Wang, Jia-Ying Zhao, Wen-Jie Chen, Xin Wang, Chen-Xia Shen, Yi-Bin Wu, Yuan-Kun Cai, Department of General Surgery, The 5 People's Hospital of Shanghai, Fudan University, Shanghai 200240, China.
    Aim: To evaluate the impact of recombinant Bacteroides fragilis enterotoxin-2 (BFT-2, or Fragilysin) on colorectal tumorigenesis in mice induced by azoxymethane/dextran sulfate sodium (AOM/DSS).

    Methods: Recombinant proBFT-2 was expressed in Escherichia coli strain Rosetta (DE3) and BFT-2 was obtained and tested for its biological activity via colorectal adenocarcinoma cell strains SW-480. Seventy C57BL/6J mice were randomly divided into a blank (BC; n = 10), model (AD; n = 20), model + low-dose toxin (ADLT; n = 20, 10 μg), and a model + high-dose toxin (ADHT; n = 20, 20 μg) group. Read More

    Differential diagnosis of well-differentiated squamous cell carcinoma from non-neoplastic oral mucosal lesions: New cytopathologic evaluation method dependent on keratinization-related parameters but not nuclear atypism.
    Diagn Cytopathol 2017 May 16;45(5):406-417. Epub 2017 Feb 16.
    Department of Oral Pathology, Osaka Dental University, Hirakata, Japan.
    Background: The cytology of oral squamous cell carcinoma (SCC) is challenging because oral SCC cells tend to be well differentiated and lack nuclear atypia, often resulting in a false negative diagnosis. The purpose of this study was to establish practical cytological parameters specific to oral SCCs.

    Methods: We reviewed 123 cases of malignancy and 53 of non-neoplastic lesions of the oral mucosa, which had been diagnosed using both cytology and histopathology specimens. Read More

    High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil.
    J Appl Oral Sci 2017 Jan-Feb;25(1):69-74
    Universidade Federal de Sergipe, Laboratório de Entomologia e Parasitologia Tropical, Departamento de Morfologia, São Cristóvão, SE, Brasil.
    Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil.

    Material And Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Read More

    Cannabidiol: an alternative therapeutic agent for oral mucositis?
    J Clin Pharm Ther 2017 Jun 12;42(3):245-250. Epub 2017 Feb 12.
    Division of Oral Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    What Is Known And Objective: Chemo- and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as well, resulting in adverse effects. Oral mucositis is especially of concern, due to the morbidity that it causes. Read More

    [Cancer and mycoses and literature review].
    Bull Soc Pathol Exot 2017 Feb 11;110(1):80-84. Epub 2017 Feb 11.
    Service de parasitologie-mycologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.
    Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Read More

    Thioredoxin and metallothionein: Homeostasis-related proteins in lip carcinogenesis.
    Arch Oral Biol 2017 May 1;77:75-81. Epub 2017 Feb 1.
    Universidade Federal de Minas Gerais, School of Dentistry, Department of Oral Surgery and Pathology, Av. Antônio Carlos 6627, Pampulha, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
    Objective: Thioredoxin (Trx) and metallothionein (MT) are involved in the development of some carcinomas; however, the role of these proteins in labial carcinogenesis has not yet been tested. The aims of the study were to evaluate and to correlate the immunoexpression of Trx and MT in actinic cheilitis, lip squamous cell carcinoma, and normal vermillion lip mucosa.

    Design: Immunohistochemistry was undertaken for Trx and MT in samples of actinic cheilitis, lip squamous cell carcinoma, and normal lip mucosa. Read More

    Dose responsive efficacy of umbelliferone on lipid peroxidation, anti-oxidant, and xenobiotic metabolism in DMBA-induced oral carcinogenesis.
    Biomed Pharmacother 2017 Apr 4;88:852-862. Epub 2017 Feb 4.
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India. Electronic address:
    This study evaluated the chemopreventive potential of umbelliferone (UMB) on 7,12- dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. The mechanistic pathway for chemopreventive potential of UMB was evaluated by measuring the status of tumour incidence, tumour volume, and tumour burden as well as by analyzing the status of phase I, phase II detoxification agents, lipid peroxidation, antioxidants, histopathological changes and also expression patterns of cell proliferation (PCNA, Cyclin D1) and apoptotic (p53) markers using immunohistochemistry in DMBA induced hamster buccal pouch carcinogenesis. Oral squamous cell carcinoma was created by painting of 0. Read More

    Osteolipoma of the buccal mucosa: A case report.
    Aust Dent J 2017 Feb 6. Epub 2017 Feb 6.
    Department of Oral Diagnostic and Surgical Sciences, School of Dentistry, University of Otago, Dunedin, New Zealand.
    Lipomas are benign mesenchymal neoplasms of soft tissue that can be found commonly in any part of the human body. Their presence in the oral mucosa is uncommon however, with approximately 4% of the cases occurring in the oral cavity(1) . Oral lipomas are likely to have originated from mature adipose tissue and there are several histological variants of lipomas described, which are identified according to the predominant type of tissue in addition to adipose tissue. Read More

    Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.
    Dermatol Surg 2017 Apr;43(4):494-506
    *Department of Dermatology, University of Massachusetts, Worcester, Massachusetts; †Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia; ‡Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Background: The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas oral-mucosal squamous cell carcinoma (omSCC) is associated with significantly higher rates of nodal disease and worse outcomes. The squamous cell carcinoma of the lip (lip SCC) is more aggressive than cSCC but less aggressive than omSCC. Read More

    Mutational Status of NRAS and BRAF Genes and Protein Expression Analysis in a Series of Primary Oral Mucosal Melanoma.
    Am J Dermatopathol 2017 Feb;39(2):104-110
    *Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil; †Department of Dermatology, School of Medicine, University of São Paulo, São Paulo, Brazil; ‡Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil; and §Department of Pathology, Obrero Hospital, La Paz, Bolivia.
    Primary oral mucosal melanoma is an extremely rare and aggressive tumor arising from melanocytes located in the mucosal epithelium of the oral cavity. Although malignant melanoma of oral mucosa shares some clinical features with its cutaneous counterpart, it has been associated with a worst prognosis; its etiopathogenesis are still only partially unraveled as there is no influence of UV radiation. It is known that the mitogen-activated protein kinase pathway mediates cellular responses to growth signals and its activation is an important phenomenon in melanoma. Read More

    Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients.
    Ann Otol Rhinol Laryngol 2017 Apr 19;126(4):340-343. Epub 2017 Jan 19.
    4 New York Center for Voice and Swallowing Disorders, New York, New York, USA.
    Objective: Metformin is an oral anti-hyperglycemic agent used to treat type 2 diabetes mellitus (DM). In vitro and animal models have shown that metformin can prevent the progression of oral lesions to carcinoma; however, there is conflicting data in the clinical literature regarding risk reduction for malignancy in head and neck cancer (HNC).

    Study Design: Case series. Read More

    Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers.
    Chem Res Toxicol 2017 01 1;30(1):367-375. Epub 2016 Dec 1.
    Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.
    This perspective considers the use of oral cell DNA adducts, together with exposure and genetic information, to potentially identify those cigarette smokers at highest risk for lung cancer, so that appropriate preventive measures could be initiated at a relatively young age before too much damage has been done. There are now well established and validated analytical methods for the quantitation of urinary and serum metabolites of tobacco smoke toxicants and carcinogens. These metabolites provide a profile of exposure and in some cases lung cancer risk, but they do not yield information on the critical DNA damage parameter that leads to mutations in cancer growth control genes such as KRAS and TP53. Read More

    Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report.
    Medicine (Baltimore) 2017 Jan;96(2):e5075
    aDepartment of Dental Surgery bDepartment of Endocrinology, Brest University Hospital, Brest cDepartment of Dermatology, Quimper Hospital, Quimper dDepartment of Oral Surgery, Brest University Hospital, Brest, France.
    Background: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Read More

    Clinics, prognosis and new therapeutic options in patients with mucosal melanoma: A retrospective analysis of 75 patients.
    Medicine (Baltimore) 2017 Jan;96(1):e5753
    aDepartment for Dermatology and Allergy, Skin Cancer Center Hannover (HTZH), Hannover Medical School bOffice for Dermatology, Allergy and Venerology, Seelze, Germany.
    Mucosal melanomas represent a rare entity with different risk factors and molecular features compared to cutaneous melanomas. They arise most commonly from mucosal surfaces in the head/neck region, the female genital tract (FGT) and the anorectal region. The aim of this study was to evaluate clinics, prognosis, and treatment options of patients with mucosal melanoma, in particular with regard to different primary sites. Read More

    Nevus Spilus (Speckled Lentiginous Nevus) in the Oral Cavity: Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 Jan;39(1):e8-e12
    *Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD; and †Department of Pathology, Walter Reed National Medical Military Center, Bethesda, MD.
    The congenital melanocytic nevus is a pigmented melanocytic lesion that presents at birth or shortly thereafter. It is commonly described on the skin, usually on the trunk and extremities. Only five intraoral cases of congenital melanocytic nevi have been described in the English literature. Read More

    MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia.
    Pathol Res Pract 2016 Dec 15;212(12):1108-1112. Epub 2016 Oct 15.
    Pontifícia Universidade Católica do Paraná, School of Health and Biosciences, Rua Imaculada Conceição, 1155, Prado Velho 80.215-901, Curitiba, PR, Brazil. Electronic address:
    The aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres. Read More

    Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision.
    Recent Pat Inflamm Allergy Drug Discov 2016 Dec 26. Epub 2016 Dec 26.
    Department of Biochemistry & Genetics, Barkatullah University, Bhopal-462 026, Madhya Pradesh, India.
    Background: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Read More

    Bioavailability of aspirin in rats comparing the drug's uptake into gastrointestinal tissue and vascular and lymphatic systems: implications on aspirin's chemopreventive action.
    J Physiol Pharmacol 2016 Oct;67(5):635-642
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston - McGovern Medical School, Houston, TX, USA.
    Aspirin is an effective analgesic and antiplatelet drug that in addition to its ability to reduce pain, inflammation and fever, appears to have efficacy in the prevention/treatment of a range of diseases including heart disease, numerous cancers and Alzheimer's. It is important to understand the bioavailability of aspirin and its major metabolite, salicylic acid, since dosage and route of administration can vary for treating differing diseases, and the major side-effects of aspirin, upper gastrointestinal ulceration and bleeding, are dose-dependent. We examined the time course for gastroduodenal uptake of aspirin and the appearance of its major metabolite salicylic acid in blood and lymph after intragastric (to simulate oral) and intraduodenal (to simulate enteric-coating) dosing in rats. Read More

    Vascular alterations after photodynamic therapy mediated by 5-aminolevulinic acid in oral leukoplakia.
    Lasers Med Sci 2017 Feb 21;32(2):379-387. Epub 2016 Dec 21.
    General Pathology Department, School of Dentistry, University of São Paulo, Av. Prof Lineu Prestes, 2227 - Cidade Universitária, 05508-000, São Paulo, SP, Brazil.
    Impairment of vascular functions after photodynamic therapy (PDT) is frequently associated with tumor remission and is considered one of the main antineoplastic PDT effects. Vascular alterations in oral leukoplakia (OL) treated with PDT have not yet been described. The aim of this study was to evaluate the effect of topical 5-ALA-mediated PDT on the vascular network of 4NQO-induced OL in rats. Read More

    Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma.
    Contemp Clin Dent 2016 Oct-Dec;7(4):524-528
    Department of Oral Pathology, Malabar Dental College, Vattamkulam, Kerala, India.
    Context: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located on chromosome 10q23. PTEN has its major function in the regulation of cell adhesion, cell cycle arrest, migration, apoptosis programming, and differentiation. This genomic region suffers loss of heterozygosity in many human cancers. Read More

    microRNA from brush biopsy to characterize oral squamous cell carcinoma epithelium.
    Cancer Med 2017 Jan 18;6(1):67-78. Epub 2016 Dec 18.
    Department of Oral Medicine and Oral Diagnostics, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois, 60610.
    Few cancers are diagnosed based on RNA expression signatures. Oral squamous cell carcinoma (OSCC) is no exception; it is currently diagnosed by scalpel biopsy followed by histopathology. This study sought to identify oral tumor epithelial microRNA (miRNA) expression changes to determine if these changes could be used to diagnose the disease noninvasively. Read More

    Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma.
    Cochrane Database Syst Rev 2016 12 11;12:CD010963. Epub 2016 Dec 11.
    Head and Neck Unit, Royal Marsden Hospital, Fulham Road, London, UK, SW3 6JJ.
    Background: More than 400,000 cases of oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed each year worldwide and the incidence is rising, partly as a result of human papillomavirus. Human papillomavirus-associated OPSCC affects younger patients and often presents at a higher stage; however, it is associated with a better prognosis.Until recently, first-line management of OPSCC involved chemoradiotherapy, as research had demonstrated comparable survival outcomes when compared with open surgery, with significantly decreased morbidity. Read More

    Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients.
    Intervirology 2016 8;59(2):123-129. Epub 2016 Dec 8.
    Division of Virology, National Center for Epidemiology, Budapest, Hungary.
    Objectives: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients.

    Methods: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used. Read More

    On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa.
    Oral Dis 2017 Apr 13;23(3):347-352. Epub 2017 Jan 13.
    Biomodels, LLC, Watertown, MA, USA.
    Objective: mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor-associated stomatitis (mIAS) a common, significant, dose-limiting toxicity, with aphthous-like lesions. Our objective was to assess the utility of a new organotypic model in defining mIAS' pathogenesis.

    Materials And Methods: The effect of everolimus on organotypic human oral mucosa was studied. Read More

    Mucormycosis Causing Ludwig Angina: A Unique Presentation.
    J Oral Maxillofac Surg 2017 Apr 29;75(4):759-762. Epub 2016 Oct 29.
    Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, IL.
    Mucormycosis is a rare fungal infection with a yearly incidence of 1.7 cases per million in the United States. It usually occurs in patients with metabolic abnormalities or who are immunocompromised with prolonged neutropenia. Read More

    Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study.
    Diagn Pathol 2016 Nov 21;11(1):134. Epub 2016 Nov 21.
    Department of Pathology, University of Medicine and Pharmacy Craiova, Petru Rares 2, Craiova, 200349, Romania.
    Background: Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT with maxillary sinus extension and the second one that also involves the buccal vestibule mucosa with peculiar histopathological and immunohistochemical data.

    Case Presentation: Here we report the case of a 45-year-old female with a CEOT diagnosed and treated at the Oral & Maxillofacial Surgery Department, County Clinical Emergency Hospital of Craiova, Romania. Read More

    Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer.
    Oral Oncol 2016 Nov 6;62:34-43. Epub 2016 Oct 6.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:
    Objectives: This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence.

    Materials And Methods: Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral precancer patients, and 95 oral squamous cell carcinoma patients. Read More

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