2 results match your criteria Cancer research frontiers[Journal]

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In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation.

Cancer Res Front 2016 May 9;2(2):311-329. Epub 2016 Jul 9.

Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA.

Mutations in the metabolic enzyme (IDH) were recently found in ~80% of WHO grade II-III gliomas and secondary glioblastomas. These mutations reduce the enzyme's ability to convert isocitrate to α-ketoglutarate and, instead, confer a novel gain-of-function resulting in the conversion of α-ketoglutarate to 2-hydroxglutarate (2-HG). However, IDH mutations exist in a heterozygous state such that a functional wild type allele is retained. Read More

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http://dx.doi.org/10.17980/2016.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417691PMC
May 2016
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Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer.

Cancer Res Front 2016 Feb 21;2(1):1-21. Epub 2016 Jan 21.

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

To date, substantial evidence has shown a significant association between inflammatory bowel diseases (IBD) and development of colitis-associated cancer (CAC). The incidence/prevalence of IBD is higher in western countries including the US, Australia, and the UK. Although CAC development is generally characterized by stepwise accumulation of genetic as well as epigenetic changes, precise mechanisms of how chronic inflammation leads to the development of CAC are largely unknown. Read More

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http://dx.doi.org/10.17980/2016.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841680PMC
February 2016
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