- Anatoly V Lichtenstein
Cancer Res 2018 Feb 22. Epub 2018 Feb 22.
Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia.
Increasing theoretical and experimental evidence suggests that the genomes of both normal and cancer cells are subject to continuous changes as a result of copying errors during replication, defects in chromosome segregation during mitosis, and direct chemical attacks by reactive oxygen species. The process of cellular genetic diversification begins during embryonic development and continues throughout life, leading to the phenomenon of somatic mosaicism. New information about the genetic diversity of cells composing the body makes us reconsider the existing concepts of cancer etiology and pathogenesis. Read More