4,114,465 results match your criteria Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique[Journal]


Breast cancer animal models and applications.

Zool Res 2020 Jul 7:1-18. Epub 2020 Jul 7.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.

Breast cancer is the most common malignancy in women. Basic and translational breast cancer research relies heavily on experimental animal models. Ideally, such models for breast cancer should have commonality with human breast cancer in terms of tumor etiology, biological behavior, pathology, and response to therapeutics. Read More

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http://dx.doi.org/10.24272/j.issn.2095-8137.2020.095DOI Listing

Protein microspheres as structuring agents in lipids: potential for reduction of total and saturated fat in food products.

J Sci Food Agric 2020 Jul 6. Epub 2020 Jul 6.

Life Quality Engineering Interest Group, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.

Excess consumption of total and saturated fats is linked to the development of chronic diseases, such as obesity, heart disease, diabetes, and cancer. There is therefore considerable interest in the development of foods containing lower levels of total and saturated fats, but that still have the same desirable physicochemical and sensory characteristics as the original foods. Solid fats normally contribute a number of key functional attributes to foods due to their ability to form crystalline networks that alter texture (such as elasticity, plasticity, and spreadability) and appearance (such as opacity and creaminess). Read More

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http://dx.doi.org/10.1002/jsfa.10645DOI Listing

Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1 resulting in tumor proliferation in CRC.

Cancer Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

BRAF mutation accounts for up to 90 % of all BRAF mutations in human colorectal cancer (CRC), and constitutively activates the MEK-MAPK pathway. It is recognized that neutralizing monoclonal antibodies for epidermal growth factor receptor alone are not effective for CRC with BRAF mutation. Therefore, there are increasing interests in identification of the possible therapeutic targets in downstream of BRAF mutation in CRCs. Read More

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http://dx.doi.org/10.1111/cas.14558DOI Listing

Letter to the Editor on "Cancer Rehabilitation Medical Knowledge for Physiatry Residents: Literature Subtopic Analysis and Synthesis into Key Domains".

PM R 2020 Jul 6. Epub 2020 Jul 6.

Department of Physical Medicine and Rehabilitation, Harvard Medical School; Massachusetts General Hospital, Brigham and Women's Hospital, and Spaulding Rehabilitation Hospital.

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http://dx.doi.org/10.1002/pmrj.12448DOI Listing

Radiofrequency thoracic sympathectomy for sympathetically maintained chronic post-mastectomy pain, a preliminary report: six months results.

Pain Pract 2020 Jul 6. Epub 2020 Jul 6.

Department of anesthesia and pain management, South Egypt Cancer Institute, Assuit University, Assiut, Egypt.

Aim: Evaluation of the analgesic efficacy of radiofrequency thoracic sympathectomy for sympathetically maintained post-mastectomy pain syndrome (PMPS).

Methods: Patients with PMPS, randomized to group TS, (n = 33) received radiofrequency thoracic sympathectomy or group SHAM, (n = 33). Post-operative pain treatment consisted of duloxetine, pregabalin, and tramadol for both groups. Read More

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http://dx.doi.org/10.1111/papr.12933DOI Listing

Use of dual lumen ports for red blood cell exchange: A comparison of adults and children with sickle cell disease.

J Clin Apher 2020 Jul 6. Epub 2020 Jul 6.

Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.

Purpose: Sickle cell patients receiving chronic RBC exchange require a form of long-term central venous access if peripheral access is inadequate. In adults, dual lumen (DL) ports have been utilized but associated with greater procedure complications and duration when compared to other forms of access. In the pediatric sickle cell population, the use of DL ports for RBC exchange has not been well described. Read More

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http://dx.doi.org/10.1002/jca.21807DOI Listing

[Surgical Treatment of Lung Cancer: How Has the Introduction of the 8th Edition of the TNM Classification Affected Guideline-Based Therapy?]

Zentralbl Chir 2020 Jul 6. Epub 2020 Jul 6.

Abteilung für Thoraxchirurgie, Universitätsklinikum Regensburg, Regensburg, Deutschland.

Study Aim: The 8th edition of the TNM classification combined with the latest update of the S3-guideline (by AWMF/Scientific Medical Societies in Germany) on prevention, diagnosis, therapy and follow-up of lung cancer led to several changes in staging and treatment of lung cancer. The aim of this study was to identify differences in the distribution of patients due to changes from the 7th to the 8th edition that affected staging. The influence on surgical therapy will be discussed by using the recommendations of the latest S3 guideline. Read More

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http://dx.doi.org/10.1055/a-1164-7058DOI Listing

Cross-sectional and prospective relationship between occupational and leisure-time inactivity and cognitive function in an ageing population: the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study.

Int J Epidemiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.

Background: The current evidence for higher physical activity and better cognitive function and lower risk of dementia is strong but not conclusive. More robust evidence is needed to inform public-health policy. We provide further insight into discrepancies observed across studies, reporting on habitual inactivity including that during work. Read More

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http://dx.doi.org/10.1093/ije/dyaa067DOI Listing

Comparison between Fluoropyrimidine-Cisplatin and Gemcitabine-Cisplatin as First-Line Chemotherapy for Advanced Biliary Tract Cancer: A Meta-Analysis.

Oncol Res Treat 2020 Jul 6:1-9. Epub 2020 Jul 6.

Department of Hematology, The First People's Hospital of Yuhang District, Hangzhou, China.

Background: Gemcitabine-cisplatin (GP) has been regarded as standard first-line chemotherapy for advanced biliary tract cancer (BTC). Fluoropyrimidine-cisplatin (FP) has also shown a survival benefit. However, the clinical choice between them is controversial. Read More

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http://dx.doi.org/10.1159/000507093DOI Listing

Phase III Randomized Study of Induction Chemotherapy Followed by Definitive Radiotherapy + Cetuximab Versus Chemoradiotherapy in Squamous Cell Carcinoma of Head and Neck: The INTERCEPTOR-GONO Study (NCT00999700).

Oncology 2020 Jul 6:1-8. Epub 2020 Jul 6.

Statistic Unit, Genova University, Genova, Italy.

Objectives: Induction chemotherapy followed by cetuximab and RT (IBRT) (Arm A) was compared to cisplatin/RT (CRT) (Arm B) in a randomized phase III study.

Patients And Methods: Naïve patients with stage III-IVa, histologically proven locally advanced head and neck cancer (LASCCHN) were eligible. Arm A (IBRT): 3 TPF induction followed by cetuximab-RT (equivalent daily dose 2 Gy up to 70 Gy); Arm B: 3 cisplatin concurrent with the same RT scheduling. Read More

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http://dx.doi.org/10.1159/000507733DOI Listing

Exome sequencing identifies somatic mutations in novel driver genes in non-small cell lung cancer.

Aging (Albany NY) 2020 Jul 6;12. Epub 2020 Jul 6.

Department of Respiration, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China.

Lung cancer is the leading cause of cancer death worldwide and accounts for more than one-third of all newly diagnosed cancer cases in China. Therefore, it is of great clinical significance to explore new driver gene mutations in non-small-cell lung cancer (NSCLC). Using an initial bioinformatic analysis, we identified somatic gene mutations in 13 patients with NSCLC and confirmed these mutations by targeted sequencing in an extended validation group of 88 patients. Read More

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http://dx.doi.org/10.18632/aging.103500DOI Listing

Reproductive and hormonal factors and bladder cancer risk: a prospective study and meta-analysis.

Aging (Albany NY) 2020 Jul 6;12. Epub 2020 Jul 6.

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.

Bladder cancer is three to four times more common among men than women. The objectives of this study were to explore the association between reproductive and hormonal factors and risk of bladder cancer among women using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) cohort, and to perform a meta-analysis based on cohort studies. After a median of 11. Read More

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http://dx.doi.org/10.18632/aging.103523DOI Listing

Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer.

iScience 2020 Jun 20;23(7):101302. Epub 2020 Jun 20.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China. Electronic address:

Ferroptosis is a type of cell death related to cancer; however, the characteristics of ferroptosis in cancers are still uncertain. Based on the data in The Cancer Genome Atlas, we found that most ferroptosis regulator genes (FRGs) were differentially expressed in tumors, somatic copy number alterations (SCNA) and DNA methylation contributed to their aberrant expression. We established the ferroptosis potential index (FPI) to reveal the functional roles of ferroptosis and noticed that the FPI was higher in tumors than in normal tissues in most cancers and was associated with subtypes and clinical features. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101302DOI Listing

Damage-associated molecular patterns in tumor radiotherapy.

Int Immunopharmacol 2020 Jul 3;86:106761. Epub 2020 Jul 3.

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Radiotherapy is one of the most common modalities for the treatment of cancer. One of the most promising effects of radiotherapy is immunologic cell death and the release of danger alarms, which are known as damage-associated molecular patterns (DAMPs). DAMPs are able to trigger cancer cells and other cells within tumor microenvironment (TME), either for suppression or promotion of tumor growth. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106761DOI Listing

State Medicaid expansion status, insurance coverage and stage at diagnosis in head and neck cancer patients.

Oral Oncol 2020 Jul 3;110:104870. Epub 2020 Jul 3.

Harvard Medical School, Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, Boston, MA, USA.

Objectives: Only one in three head and neck cancer (HNC) patients present with early-stage disease. We aimed to quantify associations between state Medicaid expansions and changes in insurance coverage rates and stage at diagnosis of HNC.

Methods: Using a quasi-experimental difference-in-differences (DID) approach and data from 26,330 cases included in the Surveillance, Epidemiology, and End Results program (2011-2015), we retrospectively examined changes in insurance coverage and stage at diagnosis of adult HNC in states that expanded Medicaid (EXP) versus those that did not (NEXP). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104870DOI Listing

Clinical-pathological prognostic factors and treatment failure patterns in T1-2 high-grade parotid gland cancer.

Oral Oncol 2020 Jul 3;110:104884. Epub 2020 Jul 3.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: The purpose of this study was to evaluate the treatment outcomes of patients with T1-2, high-grade parotid cancer, and to analyze the prognostic factors and treatment failure patterns.

Materials And Methods: Of the 101 patients who were diagnosed with high-grade parotid cancer from March 2003 to December 2018, a total of 39 males and 23 females who had T1-2 tumor were enrolled in this study.

Results: The average follow-up period of patients in this study was 63. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104884DOI Listing

Cu-selective NIR fluorescence sensor based on heptamethine cyanine in aqueous media and its application.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;240:118606. Epub 2020 Jun 19.

Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:

A near-infrared (NIR) colorimetric fluorescence sensor, Cy7C3, based on heptamethine cyanine dye was synthesized for determining the presence of Cu ions. The sensor showed highly sensitive fluorescence quenching toward Cu ions in acetonitrile/buffer solution at physiological pH with long emission wavelength of 718 nm. Cy7C3 also provided an excellent selectivity to Cu ions over other competing metal ions, with a low detection limit of 9 ppb, which was lower than the maximum concentration of Cu ions in drinking water of U. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118606DOI Listing

Evaluation of plasma EGFR mutation as an early predictor of response of erlotinib plus bevacizumab treatment in the NEJ026 study.

EBioMedicine 2020 Jul 3;57:102861. Epub 2020 Jul 3.

Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3695, Japan. Electronic address:

Background: The NEJ026 Phase 3 study demonstrated that erlotinib and bevacizumab (BE)-treated NSCLC patients with EGFR mutations had significantly better progression-free survival (PFS) than those treated with erlotinib alone (E). This study included a prospective analysis of the relationship between the mutational status of EGFR in plasma circulating tumor DNA (ctDNA) and the efficacy of TKI monotherapy or combination therapy. We describe these results herein. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102861DOI Listing

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer.

EBioMedicine 2020 Jul 3;57:102858. Epub 2020 Jul 3.

Department of Gastroenterology and Pancreatology, CHU - Rangueil and University of Toulouse, Toulouse, France.

Background: A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is the lack of molecular parameters characterizing tumours and allowing a personalized treatment.

Methods: Patient-derived xenografts (PDX) were obtained from 76 consecutive PDAC and classified according to their histology into five groups. A PDAC molecular gradient (PAMG) was constructed from PDX transcriptomes recapitulating the five histological groups along a continuous gradient. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102858DOI Listing

Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.

EBioMedicine 2020 Jul 3;57:102846. Epub 2020 Jul 3.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei 10002, Taiwan; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Jen Ai Rd, Section 1, Zhongzheng District, Taipei 10051, Taiwan. Electronic address:

Background: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms underlying lung cancer metastasis remain incompletely understood.

Methods: We performed a large-scale transcriptome-clinical correlation to identify major fucosyltransferases with significant prognostic values. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102846DOI Listing

Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq).

EBioMedicine 2020 Jul 3;57:102868. Epub 2020 Jul 3.

Neuroinflammation Unit, Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark. Electronic address:

Background: Point mutations and structural variations (SVs) in mitochondrial DNA (mtDNA) contribute to many neurodegenerative diseases. Technical limitations and heteroplasmy, however, have impeded their identification, preventing these changes from being examined in neurons in healthy and disease states.

Methods: We have developed a high-resolution technique-Mitochondrial DNA Structural Variation Sequencing (MitoSV-seq)-that identifies all types of mtDNA SVs and single-nucleotide variations (SNVs) in single neurons and novel variations that have been undetectable with conventional techniques. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102868DOI Listing

Single cell genomics and developmental biology: moving beyond the generation of cell type catalogues.

Curr Opin Genet Dev 2020 Jul 3;64:66-71. Epub 2020 Jul 3.

Department of Haematology, University of Cambridge, Cambridge, UK; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. Electronic address:

Major developmental processes such as gastrulation and early embryogenesis rely on a complex network of cell-cell interactions, chromatin remodeling, and transcriptional regulators. This makes it challenging to study early development when using bulk populations of cells. Recent advances in single-cell technologies have allowed researchers to better understand the interactions between different molecular modalities and the heterogeneities within classically defined cell types. Read More

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http://dx.doi.org/10.1016/j.gde.2020.05.033DOI Listing

Prognostic nomogram in patients with metastatic adenoid cystic carcinoma of the salivary glands.

Eur J Cancer 2020 Jul 3;136:35-42. Epub 2020 Jul 3.

Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy.

Background: Distant metastases in adenoid cystic carcinoma (ACC) are common. There is no consensus on the management of metastatic disease because no therapeutic approach has demonstrated improvement in overall survival (OS) and because of prolonged life expectancy. The aim of this study is to build and validate a prognostic nomogram for metastatic ACC patients. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.05.013DOI Listing

Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients.

Mult Scler Relat Disord 2020 Jun 2;44:102251. Epub 2020 Jun 2.

Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom; Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom; Department of Neurology, The Cleveland Clinic Abu Dhabi, United Arab Emirates. Electronic address:

Objective: To assess the effect of anti-CD20 B-cell depletion with rituximab (RTX) on relapse rates in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD).

Methods: Retrospective review of RTX-treated MOGAD patients from 29 centres in 13 countries. The primary outcome measure was change in relapse rate after starting rituximab (Poisson regression model). Read More

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http://dx.doi.org/10.1016/j.msard.2020.102251DOI Listing

The 5-Ws of immunotherapy in head and neck cancer.

Crit Rev Oncol Hematol 2020 Jun 30;153:103041. Epub 2020 Jun 30.

Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.

The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.103041DOI Listing

CLIN-IK-LINKS: A platform for the design and execution of clinical data transformation and reasoning workflows.

Comput Methods Programs Biomed 2020 Jun 25;197:105616. Epub 2020 Jun 25.

Department of Computer Engineering and Science, Universitat Jaume I, Spain.

Background And Objective: Effective sharing and reuse of Electronic Health Records (EHR) requires technological solutions which deal with different representations and different models of data. This includes information models, domain models and, ideally, inference models, which enable clinical decision support based on a knowledge base and facts. Our goal is to develop a framework to support EHR interoperability based on transformation and reasoning services intended for clinical data and knowledge. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105616DOI Listing

Norcolocynthenins A and B, two cucurbitane 3-nor-Triterpenoids from Citrullus colocynthis and their cytotoxicity.

Bioorg Chem 2020 Jun 25;101:104045. Epub 2020 Jun 25.

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang330022, China; The Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address:

Two novel cucurbitane 3-nor-triterpenoids, named norcolocynthenins A (1) and B (2), were isolated from the fruits of Citrullus colocynthis. The structures including their absolute configurations were determined by extensive spectroscopic analyses and theoretical calculations. Compound 1 features an unprecedented 5/6/6/5-fused ring system while compound 2 possesses a rare lactone moiety at modified ring A. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104045DOI Listing

Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases.

Bioorg Chem 2020 Jun 24;101:104039. Epub 2020 Jun 24.

Medicinal and Biological Chemistry Group, Institute of Chemistry of São Carlos, University of São Paulo, Avenue Trabalhador Sancarlense, 400, 23566-590 São Carlos, SP, Brazil. Electronic address:

Cysteine proteases (CPs) are involved in a myriad of actions that include not only protein degradation, but also play an essential biological role in infectious and systemic diseases such as cancer. CPs also act as biomarkers and can be reached by active-based probes for diagnostic and mechanistic purposes that are critical in health and disease. In this paper, we present the modulation of a CP panel of parasites and mammals (Trypanosoma cruzi cruzain, LmCPB, CatK, CatL and CatS), whose inhibition by nitrile peptidomimetics allowed the identification of specificity and selectivity for a given CP. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104039DOI Listing

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A receptors. Design, synthesis and biological evaluation.

Bioorg Chem 2020 Jun 19;101:104033. Epub 2020 Jun 19.

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30688 Kraków, Poland. Electronic address:

A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and benzyloxy substitution) as well as at N1, N3, and N7 (small alkyl residues), thereby improving affinity and selectivity for the A AR. The compounds were characterized by radioligand binding assays, and our study resulted in the development of the potent A AR ligands including 8-((6-chloro-2-fluoro-3-methoxybenzyl)amino)-1-ethyl-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione (12d; K human AAR: 68. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104033DOI Listing

Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones.

Bioorg Chem 2020 Jun 19;101:104031. Epub 2020 Jun 19.

Department of Chemistry, University of Florida, Gainesville, FL, United States. Electronic address:

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramolecular dehydrogentaive cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104031DOI Listing

Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity.

Bioorg Chem 2020 Jun 15;101:104017. Epub 2020 Jun 15.

Universidade Federal de Mato Grosso do Sul, Instituto de Química, Laboratório LP4, Av. Filinto Müller, 1555, 79074-460 Campo Grande (MS), Brazil. Electronic address:

Diaryl disulfides and diaryl thiosulfonates were synthesized with the two phenyl rings of all compounds bearing identical halide substituents. Because of structural similarity to the potent antimitotic natural product combretastatin A-4 (CA-4), the compounds were examined for inhibition of tubulin polymerization, and the thiosulfonates were more active than the disulfides. The nine thiosulfonates had IC values ranging from 1. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104017DOI Listing

Grape pomace inhibits colon carcinogenesis by suppressing cell proliferation and inducing epigenetic modifications.

J Nutr Biochem 2020 Jun 2;84:108443. Epub 2020 Jun 2.

School of Food Science, Washington State University, Pullman, WA, USA. Electronic address:

Grape pomace (GP), a by-product of the wine and juice industry, is rich in bioflavonoids and dietary fibers. We hypothesized that GP has protective effects against colitis-associated colorectal cancer (CRC). Nine-week-old female mice were fed a control diet (CON) or CON with 5% grape pomace (GP) for 2 weeks, when mice were subjected to azoxymethane (AOM)/dextran sulfate sodium (DSS) induced-CRC induction. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108443DOI Listing

Using taTME to maintain restorative options in locally advanced rectal cancer: A technical note.

Int J Surg Case Rep 2020 Jun 12;73:39-43. Epub 2020 Jun 12.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, Australia; University of Melbourne, Melbourne, Australia. Electronic address:

Background: The safe adoption of transanal total mesorectal excision (taTME) has occurred in Australasia as previously reported by the current authors. Planes beyond TME can be utilised in more advanced cases to achieve negative margins during transanal dissection.

Methods: In this article we describe how taTME is used to perform an en-bloc partial vaginectomy and aid restore intestinal and vaginal continuity in a young female with a locally advanced rectal cancer and posterior vaginal wall involvement in the pre-treatment magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.015DOI Listing

Spontaneous perforation of jejunal gastrointestinal stromal tumor: A case report.

Int J Surg Case Rep 2020 Jun 27;73:31-34. Epub 2020 Jun 27.

Department of Radiology, Jordanian Royal Medical Services (JRMS), Amman, Jordan. Electronic address:

Introduction: The incidence of small bowel tumors is comparatively rare when compared to colonic tumors. They comprise less than 10% of all gastrointestinal neoplasms. Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract; however it accounts for less than 1% of all gastrointestinal tumors. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.088DOI Listing

The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review.

Psychiatry Res Neuroimaging 2020 Jul 3;303:111135. Epub 2020 Jul 3.

Cornell Center for Research on End-of-life Care, Weill Cornell Medicine, 420 E. 70th St., New York, NY 10021, USA; Department of Medicine, Weill Cornell Medicine, 1320 York Ave., New York, NY 10021, USA. Electronic address:

Prolonged Grief Disorder (PGD) is a debilitating condition affecting between 7% and 10% of bereaved individuals. Past imaging and psychological studies have proposed links between PGD's characteristic symptoms - in particular, profound yearning - and the neural reward system. We conducted a systematic review to investigate this connection. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2020.111135DOI Listing

Improvement of organisms by biomimetic mineralization: a material incorporation strategy for biological modification.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027 China; Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310027 China. Electronic address:

Biomineralization, a bio-organism controlled mineral formation process, plays an important role in linking biological organisms and mineral materials in nature. Inspired by biomineralization, biomimetic mineralization is used as a bridge tool to integrate biological organisms and functional materials together, which can be beneficial for the development of diversified functional organism-material hybrids. In this review, recent progresses on the techniques of biomimetic mineralization for organism-material combinations are summarized and discussed. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.038DOI Listing

X-ray and NIR Light Dual-triggered Mesoporous Upconversion Nanophosphor/Bi Heterojunction Radiosensitizer for Highly Efficient Tumor Ablation.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Institute of Bismuth Science, College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based nanomaterial loaded with iron phthalocyanine for X-ray and NIR light dual-triggered tri-modal tumor therapy. NaLuF:Yb,Tm, a Lu-based UCNP, offers radiosensitization and upconversion luminescence for optical bio-imaging. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.044DOI Listing

BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases.

Neoplasia 2020 Jul 3;22(9):376-389. Epub 2020 Jul 3.

The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA; Masonic Cancer Center, 2231 6th St SE, Minneapolis, MN 5545, USA. Electronic address:

The development of mutant BRAF inhibitors has improved the outcome for melanoma patients with BRAF mutations. Although the initial response to these inhibitors can be dramatic, sometimes resulting in complete tumor regression, the majority of melanomas become resistant. To study resistance to BRAF inhibition, we developed a novel mouse model of melanoma using a tetracycline/doxycycline-regulated system that permits control of mutant BRAF expression. Read More

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http://dx.doi.org/10.1016/j.neo.2020.06.006DOI Listing

Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.

Neoplasia 2020 Jul 3;22(9):365-375. Epub 2020 Jul 3.

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China. Electronic address:

The addition of bevacizumab to chemotherapy has prolonged overall and progression-free survival rates for metastatic colorectal cancer (mCRC). However, KRAS-mutant (KRAS-mut) CRC, lacking an ideal targeted agent, represents an inferior-response subgroup of patients. In the present study, we investigated a combination approach of bevacizumab + olaparib in KRAS-mut CRC in a preclinical setting. Read More

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http://dx.doi.org/10.1016/j.neo.2020.06.001DOI Listing

TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance.

Neoplasia 2020 Jul 3;22(9):352-364. Epub 2020 Jul 3.

Department of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States. Electronic address:

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a discouraging prognosis. Its aggressive and highly infiltrative nature renders the current standard treatment of maximal surgical resection, radiation, and chemotherapy relatively ineffective. Identifying the signaling pathways that regulate GBM migration/invasion and resistance is required to develop more effective therapeutic regimens to treat GBM. Read More

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http://dx.doi.org/10.1016/j.neo.2020.06.005DOI Listing

Modulating the modulators: regulation of protein arginine methyltransferases by post-translational modifications.

Drug Discov Today 2020 Jul 3. Epub 2020 Jul 3.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA; Department of Medical and Molecular Genetics, 975 W. Walnut Street, Indianapolis, IN 46202, USA. Electronic address:

The therapeutic potential of targeting protein arginine methyltransferases (PRMTs) is inextricably linked to their key roles in various cellular functions, including splicing, proliferation, cell cycle regulation, differentiation, and DNA damage signaling. Unsurprisingly, the development of inhibitors against these enzymes has become a rapidly expanding research area. However, effective targeting of PRMTs requires a deeper understanding of the mechanistic details behind their regulation at multiple levels, involving those mechanisms that alter their activity, interactions, and localization. Read More

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http://dx.doi.org/10.1016/j.drudis.2020.06.031DOI Listing

Engineering extracellular matrix to improve drug delivery for cancer therapy.

Drug Discov Today 2020 Jul 3. Epub 2020 Jul 3.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic address:

As an effective platform to deliver therapeutic drugs into tumors, nanoparticles (NPs) have shown great potential for cancer therapy. However, the tumor microenvironment (TME) contains diverse barriers to the transport of NPs, particularly the dense extracellular matrix (ECM). Thus, engineering the tumor ECM is a promising way to improve drug delivery by degrading existing ECM and/or blocking ECM synthesis. Read More

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http://dx.doi.org/10.1016/j.drudis.2020.06.029DOI Listing

Integra® dermal regeneration template for full thickness carcinologic scalp defects: our 6 years' experience retrospective cohort and literature review.

J Stomatol Oral Maxillofac Surg 2020 Jul 3. Epub 2020 Jul 3.

Plastic and Reconstructive Surgery Department, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94805, France.

Background: The aim of the study is the use of Integra® dermal regeneration template (DRT) in scalp reconstruction after tumor resection by comparing results of literature and Gustave Roussy Institut' series of 20 patients. Materiel and methods: A systematic review, with a PubMed search was performed using the following keywords "artificial dermis OR DRT" AND "scalp". Eligible articles were selected to study patients and defects characteristics, operative modalities, and the follow up results. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.06.016DOI Listing

Low Non-Relapse Mortality after HLA Matched Related Two-Step Hematopoietic Stem Cell Transplantation using Cyclophosphamide (CY) for Graft versus Host Disease Prophylaxis and the Potential Impact of Non-CY-Exposed T Cells on Outcomes.

Biol Blood Marrow Transplant 2020 Jul 3. Epub 2020 Jul 3.

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University.

The use of cyclophosphamide (CY) for bidirectional tolerization of recipient and donor T cells is associated with reduced rates of graft versus host disease (GVHD) and non-relapse mortality (NRM) after human leukocyte antigen (HLA) matched hematopoietic stem cell transplantation (HSCT). However, recurrent disease remains the primary barrier to long term survival. We extended our two-step approach to HLA matched related HSCT using a radiation-based myeloablative conditioning regimen combined with a high dose of T cells in an attempt to reduce relapse rates while maintaining the beneficial effects of CY tolerization. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.06.021DOI Listing

Influence of adherence with guideline-driven recommendations on survival in women operated for breast cancer: Real-life evidence from Italy.

Breast 2020 Jul 1;53:51-58. Epub 2020 Jul 1.

Authority for Healthcare and Welfare, Emilia Romagna Regional Health Service, Bologna, Italy.

Background: A set of indicators to assess the quality of care for women operated for breast cancer was developed by an expert working group of the Italian Health Ministry in order to compare the Italian regions. A study to validate these indicators through their relationship with survival was carried out.

Methods: The 16,753 women who were residents in three Italian regions (Lombardy, Emilia-Romagna and Lazio) and hospitalized for breast cancer surgery during 2011 entered the cohort and were followed until 2016. Read More

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http://dx.doi.org/10.1016/j.breast.2020.06.010DOI Listing

Predictive validity of the adult tobacco dependence index: Findings from waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) study.

Drug Alcohol Depend 2020 Jun 30;214:108134. Epub 2020 Jun 30.

College of Global Public Health, New York University, United States.

Background And Aims: Building on published work establishing concurrent validity of a self-report tobacco dependence (TD) index among users of different tobacco products in Wave 1 (W1) of the Population Assessment of Tobacco and Health (PATH) Study, the current study examines prospective relationships with tobacco use behaviors to establish predictive validity of the TD index. Hypotheses suggested high levels of W1 TD would be associated with persistent tobacco use at Wave 2 (W2).

Participants: A U. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108134DOI Listing

Prognosis and targeting of pre-metastatic niche.

J Control Release 2020 Jul 3. Epub 2020 Jul 3.

Institute of Pharmaceutics, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

As the main cause of tumoral fatality, metastasis remains to be one of the most urgent difficulties researcher struggled to overcome. During the development and progression of metastasis, the establishment of pre-metastatic niche is crucial in preparing fertile microenvironment for disseminated tumor cells settlement and colonization in distant metastatic target sites. The key participators, including the primary tumor-derived factors, bone marrow-derived cells, stromal cells of both the host and the potential metastatic sites, regulate the temporal progress of potential metastasis. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.037DOI Listing

Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery.

J Control Release 2020 Jul 3. Epub 2020 Jul 3.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address:

Polymeric microneedles (MNs) have been leveraged as a novel transdermal drug delivery platform for effective drug permeation, which were widely used in the treatment of various diseases. However, issues including limited loading capacity of hydrophobic drugs, uncontrollable drug release rates, and monotonic therapeutic strategy hamper the further application of polymeric MNs. As a recent emerging research topic, drawing inspiration from the ways that nanomedicine integrated with MNs have opened new avenues for disease therapy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.039DOI Listing

Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo.

J Control Release 2020 Jul 3. Epub 2020 Jul 3.

The University of Texas Southwestern Medical Center, Department of Biochemistry, Simmons Comprehensive Cancer Center, Dallas, TX 75390, United States. Electronic address:

mRNA-based therapeutics have emerged as a promising approach to treat cancer. However, creation of theranostic strategies to both deliver mRNA and simultaneously detect cancer is an important unmet goal. Here, we report the development of theranostic dendrimer-based lipid nanoparticle (DLNP) system containing PEGylated BODIPY dyes (PBD) for mRNA delivery and near-infrared (NIR) imaging in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.030DOI Listing

Patient-Reported Barriers are Associated with Receipt of Hepatocellular Carcinoma Surveillance in a Multi-Center Cohort of Patients with Cirrhosis.

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX; Department of Medicine, Baylor College of Medicine, Houston, TX.

Background: More than 20% of patients with cirrhosis do not receive semi-annual hepatocellular carcinoma (HCC) surveillance as recommended. Few studies have evaluated the effects of patient-level factors on surveillance receipt.

Methods: We administered a telephone survey to a large cohort of patients with cirrhosis from 3 health systems (a tertiary care referral center, a safety-net health system, and Veterans Affairs) to characterize patient knowledge, attitudes, and perceived barriers of HCC surveillance. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.049DOI Listing
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