3,811,352 results match your criteria Cancer prevention research Philadelphia Pa.[Journal]


Local tumor response and survival outcomes after combined stereotactic radiosurgery and immunotherapy in non-small cell lung cancer with brain metastases.

J Neurosurg 2019 Feb 15:1-6. Epub 2019 Feb 15.

1Department of Neurosurgery, Yale New Haven Hospital, New Haven, Connecticut.

OBJECTIVEConcurrent use of anti-PD-1 therapies with stereotactic radiosurgery (SRS) have been shown to be beneficial for survival and local lesional control in melanoma patients with brain metastases. It is not known, however, if immunotherapy (IT) confers the same outcome advantage in lung cancer patients with brain metastases treated with SRS.METHODSThe authors retrospectively reviewed 85 non-small cell lung cancer (NSCLC) patients with brain metastases who were treated with SRS between January 2006 and December 2016. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181371DOI Listing
February 2019

Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Somatotopic organization of the human spinothalamic tract: in vivo computed tomography-guided mapping in awake patients undergoing cordotomy.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

3Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

OBJECTIVEThe location of the human spinothalamic tract (STT) in the anterolateral spinal cord has been known for more than a century. The exact nature of the neuronal fiber lamination within the STT, however, remains controversial. After correlating in vivo macrostimulation-induced pain/temperature sensation during percutaneous cervical cordotomy with simultaneous CT imaging of the electrode tip location, the authors present a modern description of the somatotopy of the human cervical STT. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18172DOI Listing
February 2019

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

3Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, Quebec, Canada.

Leptomeningeal dissemination (LMD) is the defining pattern of metastasis for medulloblastoma. Although LMD is responsible for virtually 100% of medulloblastoma deaths, it remains the least well-understood part of medulloblastoma pathogenesis. The fact that medulloblastomas rarely metastasize outside the CNS but rather spread almost exclusively to the spinal and intracranial leptomeninges has fostered the long-held belief that medulloblastoma cells spread directly through the CSF, not the bloodstream. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18506DOI Listing
February 2019

Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.

Environ Pollut 2019 Feb 7;248:28-35. Epub 2019 Feb 7.

Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA. Electronic address:

Background: Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.129DOI Listing
February 2019

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

Eur J Cancer 2019 Feb 13;110:62-70. Epub 2019 Feb 13.

Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, the Netherlands. Electronic address:

Aim: Salivary duct carcinoma (SDC), an aggressive subtype of salivary gland cancer, is androgen receptor (AR)-positive in 67-96% of cases. In patients with locally recurrent and metastatic (R/M) AR-positive SDC, androgen deprivation therapy (ADT) has an overall response rate of 18-64.7%. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.035DOI Listing
February 2019

Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
February 2019

Recent advances of anti-cancer therapies including the use of cell-penetrating peptides.

Curr Opin Pharmacol 2019 Feb 13;47:8-13. Epub 2019 Feb 13.

University of Cologne, Department of Chemistry, Biochemistry, Zülpicher Str. 47a, 50674 Cologne, Germany. Electronic address:

Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bioavailability. Read More

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http://dx.doi.org/10.1016/j.coph.2019.01.003DOI Listing
February 2019

Risk factors for pelvic and distant recurrence in locally advanced cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:6-12. Epub 2019 Feb 6.

Medical Oncology Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. Electronic address:

Objective: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.028DOI Listing
February 2019

Photoelectrochemical platform for MicroRNA let-7a detection based on graphdiyne loaded with AuNPs modified electrode coupled with alkaline phosphatase.

Biosens Bioelectron 2019 Feb 4;130:269-275. Epub 2019 Feb 4.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; State Key Laboratory Base of Eco-chemical Engineering; Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Provincial Key Laboratory of Rubber Plastics; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

In this work, a photoactive material, Graphdiyne (GDY) loaded with AuNPs (AuNPs-GDY), was successfully synthesized. The fabricated material made use of the natural band-gap structure of GDY, which could produce hole-electron pairs and the plasmon resonance effect of AuNPs to obtain a high photoelectrochemical (PEC) response. AuNPs-GDY PEC response changed with the mass ratio of GDY to tetrachloroauric acid. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.002DOI Listing
February 2019

Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004-2013.

Cancer Epidemiol 2019 Feb 13;59:143-147. Epub 2019 Feb 13.

Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology Group, Folkhälsan Research Center, Faculty of Medicine, Helsinki University, Helsinki, Finland; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

Introduction: Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013.

Methods: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.003DOI Listing
February 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019

ICU readmission of patients with cancer: Incidence, risk factors and mortality.

J Crit Care 2019 Feb 7;51:84-87. Epub 2019 Feb 7.

Department of Medicine, Section of Pulmonary and Critical Care, King Hussein Cancer Center, Jordan. Electronic address:

Purpose: Few studies evaluated ICU readmission in cancer patients. This study aimed to describe the incidence and risk factors for ICU readmission in cancer patients and the association with mortality.

Materials And Methods: A retrospective cohort study at a comprehensive cancer center, which included cancer patients who were discharged after their initial ICU admission over a 5-year period. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.008DOI Listing
February 2019

Unfractionated Heparin Alleviates Sepsis-Induced Acute Lung Injury by Protecting Tight Junctions.

J Surg Res 2019 Feb 13;238:175-185. Epub 2019 Feb 13.

Department of Critical Care Medicine, The First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China. Electronic address:

Background: Unfractionated heparin (UFH) has been shown to ameliorate lung edema and lung vascular leakage in lipopolysaccharide-induced lung injury. Impaired tight junction (TJ) function is a sign of sepsis-induced acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), which is closely related to the downregulated expression of TJ-specific proteins or the upregulated expression of inflammatory cytokines. Because UFH has been intensively studied in modulating inflammation, we hypothesize that UFH may play a positive role in treating sepsis-induced ARDS/ALI by protecting TJs. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.020DOI Listing
February 2019

SELDI-TOF MS Analysis of Hepatocellular Carcinoma in an Australian Cohort.

J Surg Res 2019 Feb 13;238:127-136. Epub 2019 Feb 13.

Cancer Surgery and Metabolism Research Group, University of Sydney, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, NSW, Australia; Discipline of Surgery, The University of Sydney, Camperdown, NSW, Australia.

Background: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.008DOI Listing
February 2019

Utility of Likert scale (Deauville criteria) in assessment of Chemoradiotherapy response of primary oropharyngeal squamous cell Cancer site.

Clin Imaging 2019 Jan 16;55:89-94. Epub 2019 Jan 16.

Department of Radiology, Division of Nuclear Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Introduction: The aim of this study is to determine whether Likert scale (Deauville criteria) can be used to classify oropharyngeal squamous cell cancer (OPSCC) patients as 'responders' and 'nonresponders' by utilizing FDG-PET/CT for primary tumor site. The second aim is to compare the performance of methods used in interpretation of posttreatment PET/CT scans (Likert scale, SUVmax, ratios of SUVmax primary lesion to mediastinum 'SUVmax P/M' and SUVmax primary lesion to liver 'SUVmax P/L') in predicting treatment response.

Methods: Seventy-seven PET/CT scans were assessed by Deauville criteria, five-point Likert scale. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.007DOI Listing
January 2019

Comparison of TSNAs concentration in saliva according to type of tobacco smoked.

Environ Res 2018 Dec 6;172:73-80. Epub 2018 Dec 6.

Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Cancer Prevention and Control Group, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Objective: To compare tobacco-specific nitrosamines (TSNAs) measured in saliva according to different types of tobacco smoked in a sample of smokers of the city of Barcelona (Spain).

Methods: We used data from a cross-sectional study of a sample of the adult smoking population of Barcelona, Spain in 2013-2014 (n = 165). We classified smokers in five groups according to the type of tobacco smoked: a) manufactured cigarettes only, b) roll-your-own (RYO) cigarettes only, c) dual smokers (both manufactured and RYO cigarettes), d) manufactured plus other types of tobacco products different from RYO and e) other types of tobacco products different from manufactured and RYO cigarettes. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.006DOI Listing
December 2018

A rare case of transient left ventricular apical ballooning syndrome following living donor liver transplantation: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:218-222. Epub 2019 Feb 10.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Introduction: Transient Left Ventricular Apical Balloon Syndrome (LV-ABS) is an unknown acute dysfunction of the left ventricle, which develops under emotional or physical stress events like the major surgical postoperative period.

Presentation Of Case: A 68-year-old woman diagnosed with hepatitis C cirrhosis was admitted for living donor liver transplantation (LDLT). No evidence for underlying cardiac or pulmonary disease was found. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193006
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http://dx.doi.org/10.1016/j.ijscr.2019.02.002DOI Listing
February 2019

Exploring anxiety sensitivity in the relationship between pain intensity and opioid misuse among opioid-using adults with chronic pain.

J Psychiatr Res 2019 Feb 8;111:154-159. Epub 2019 Feb 8.

Department of Psychology, University of Houston, USA; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, USA; HEALTH Institute, University of Houston, USA. Electronic address:

Opioid misuse is a significant public health problem. Chronic pain is one highly prevalent factor that is strongly associated with increased risk for opioid misuse. Anxiety sensitivity (fear of anxiety related physical sensations) is an individual difference factor consistently linked to pain experience, and separately, heroin use. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.004DOI Listing
February 2019

TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells.

Mol Ther Nucleic Acids 2019 Jan 18;14:567-582. Epub 2019 Jan 18.

Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China. Electronic address:

Chemoresistance remains a great obstacle in effective lung adenocarcinoma (LUAD) treatment. Previously, we verified the role of microRNA-200b (miR-200b) in the formation of docetaxel (DTX)-resistant LUAD cells. This study aims to investigate the mechanism underlying the low level of miR-200b in DTX-resistant LUAD cells. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.005DOI Listing
January 2019

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever.

Int J Parasitol Drugs Drug Resist 2019 Jan 25;9:80-86. Epub 2019 Jan 25.

International Livestock Research Institute, P. O. Box 30709, Nairobi, Kenya. Electronic address:

Chemotherapy of East Coast fever, a lymphoproliferative cancer-like disease of cattle causing significant economic losses in Africa, is largely dependent on the use of buparvaquone, a drug that was developed in the late 1980's. The disease is caused by the tick-borne protozoan pathogen Theileria parva. Buparvaquone can be used prophylactically and it is also active against tropical theileriosis, caused by the related parasite Theileria annulata. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.01.002DOI Listing
January 2019

Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.

Eur J Med Chem 2019 Feb 7;167:153-160. Epub 2019 Feb 7.

Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0914, Japan; Graduate School of Innovative Life Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

MutT homologue 1 (MTH1) protects the nucleotide pool from oxidative stress by hydrolyzing oxidized nucleoside triphosphates and prevents their incorporation into DNA. Cancer cells are dependent on the MTH1 activity for survival due to the high-level of reactive oxygen species in cancer cells; therefore, MTH1 is considered to be a novel target for treatment of various cancers. Here, we show by X-ray crystallographic screening using an in-house cocktail library that α-mangostin, a natural xanthone from mangosteen pericarp, binds to the active site of MTH1. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.011DOI Listing
February 2019

Polymeric prodrug microspheres with tumor intracellular microenvironment bioreducible degradation, pH-triggered "off-on" fluorescence and drug release for precise imaging-guided diagnosis and chemotherapy.

Colloids Surf B Biointerfaces 2019 Feb 4;177:313-320. Epub 2019 Feb 4.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address:

Theranostic nanoplatforms have been recognized for imaging-guided diagnosis and chemotherapy of cancer by integrating imaging function into the drug delivery systems (DDSs). Here, a facile approach was developed for the fabrication of polymeric prodrug microspheres by introducing pH sensitive "off-on" fluorochrome Rhodamine 6G into bioreducible cleavable bisulfide crosslinked PEGylated poly(glycidyl methacrylate) (PEG-PGMA) microspheres, followed with chemical conjugation of doxorubicin (DOX) via an acid-labile hydrazone linkage. High drug content of 25. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.002DOI Listing
February 2019

One-step preparation of gold nanovectors using folate modified polyethylenimine and their use in target-specific gene transfection.

Colloids Surf B Biointerfaces 2019 Feb 6;177:306-312. Epub 2019 Feb 6.

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.

Gene transfection, as an effective treatment for inherited and acquired life threatening diseases caused by genetic deficiencies and abnormalities, has evolved as a promising therapeutic strategy for cancer and other intractable diseases. Non-target-specific vectors will affect normal cells as well as pathogenic cells, resulting in a relative decrease in transfection efficiency and unnecessary cytotoxicity. In the present work, gold nanoparticles (AuNPs) functionalized with folate (FA)-modified polyethylenimine (PEI-FA) were prepared by a single step method (without additional reducing agent) for targeted gene transfection in tumor cells. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.011DOI Listing
February 2019

Indocyanine green/doxorubicin-encapsulated functionalized nanoparticles for effective combination therapy against human MDR breast cancer.

Colloids Surf B Biointerfaces 2019 Feb 5;177:294-305. Epub 2019 Feb 5.

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300, Taiwan. Electronic address:

To overcome low therapeutic efficacy of chemotherapy against multidrug resistance (MDR) breast cancer, a combination therapy system based upon functionalized polymer nanoparticles comprising poly(γ-glutamic acid)-g-poly(lactic-co-glycolic acid) (γ-PGA-g-PLGA) as the major component was developed. The NPs were loaded with doxorubicin (DOX) and indocyanine green (ICG) for dual modality cancer treatment and coated with cholesterol-PEG (C-PEG) for MDR abrogation in treatment of human MDR breast cancer. The in vitro cellular uptake of the DOX/ICG loaded nanoparticles (DI-NPs) by MDR cancer cells was significantly enhanced owing to effective inhibition of the P-gp activity by C-PEG and γ-PGA receptor-mediated endocytosis. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.001DOI Listing
February 2019

Aquaporin-4 antibody positive short transverse myelitis associated with breast cancer.

Mult Scler Relat Disord 2019 Feb 8;30:119-122. Epub 2019 Feb 8.

Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS). A typical finding on spinal magnetic resonance imaging (MRI) of NMOSD is longitudinally extensive transverse myelitis (LETM). However, patients with NMOSD presenting with short-segment transverse myelitis (STM) during myelitis attacks associated with breast cancer are uncommon. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.011DOI Listing
February 2019

Polymers with distinctive anticancer mechanism that kills MDR cancer cells and inhibits tumor metastasis.

Biomaterials 2019 Jan 25;199:76-87. Epub 2019 Jan 25.

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 138669, Singapore. Electronic address:

Although mortality continues to decline over the past two decades, cancer is still a pervasive healthcare problem worldwide due to the increase in the number of cases, multidrug resistance (MDR) and metastasis. As a consequence of multidrug resistance, cancer treatment must rely on a host of chemotherapeutic agents and chemosensitizers to achieve remission. To overcome these problems, a series of biodegradable triblock copolymers of PEG, guanidinium-functionalized polycarbonate and polylactide (PEG-PGC-PDLA) is designed as chemotherapeutic agents. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.036DOI Listing
January 2019

RAMS: Remote and automatic mammogram screening.

Comput Biol Med 2019 Feb 5;107:18-29. Epub 2019 Feb 5.

Quality of Life Technology Laboratory, Department of Electrical and Computer Engineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX, 75080, USA. Electronic address:

About one in eight women in the U.S. will develop invasive breast cancer at some point in life. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.01.024DOI Listing
February 2019

Advances in Immunotherapy Delivery from Implantable and Injectable Biomaterials.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Department of Bioengineering, Rice University, Houston, TX 77005, United states. Electronic address:

Macroscale biomaterials, such as preformed implantable scaffolds and injectable soft materials, possess powerful synergies with anti-cancer immunotherapies. Immunotherapies on their own typically have poor delivery properties, and often require repeated high-dose injections that result in serious off-tumor effects and/or limited efficacy. Rationally designed biomaterials allow for discrete localization and controlled release of immunotherapeutic agents, and have been shown in a large number of applications to improve outcomes in the treatment of cancers via immunotherapy. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.016DOI Listing
February 2019

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China; Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan, PR China; Center for Information in Biology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China. Electronic address:

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM stiffness in cancer is well known. However, the biomechanical behavior of tumor cells and the underlying mechanotransduction pathways remain unclear. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.015DOI Listing
February 2019

Outcomes of Long-term Interval Rescreening with Low-Dose CT for Lung Cancer in Different Risk Cohorts.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiothoracic Imaging, Toronto Joint Department of Medical Imaging, University of Toronto, Toronto, Canada.

Hypothesis: We hypothesize that the incidence of screen-detected lung cancer (LC), in participants with previously negative scans, will be highest in the cohort with the highest baseline risk score.

Methods: Individuals with negative baseline screening results from the Princess Margaret International Early Lung Cancer Action Program prior to 2009 underwent low-dose CT rescreening from 2015 to 2018. Individuals were contacted in order of descending risk, as determined by the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial's PLCO 6-year LC risk-prediction model, and then categorized into three risk cohorts according to their baseline risks. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.031DOI Listing
February 2019

Chk1 inhibition enhances cisplatin cytotoxicity and overcomes cisplatin resistance in small cell lung cancer by promoting mitotic cell death.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology, Georgetown University Medical Center, Washington, DC. Electronic address:

Introduction: Platinum-based chemotherapy remains the standard treatment for patients with small cell lung cancer (SCLC), but the benefit of the treatment is often hampered by rapid development of drug resistance. Thus far, there is no targeted therapy available for SCLC. Over 90% of SCLC tumors harbor mutations in the tumor suppressor gene p53, an important DNA damage checkpoint regulator, and these tumor cells rely predominantly on the checkpoint kinases to control DNA damage response. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.028DOI Listing
February 2019

The Combination of MEK inhibitor with Immunomodulatory Antibodies Targeting PD-1 and PD-L1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Section of Medical Oncology, Department of Internal Medicine; Developmental Therapeutics Translational Research Program, Yale Comprehensive Cancer Center, New Haven, Connecticut , USA. Electronic address:

Purpose: To characterize the tumor-infiltrating immune cells population in Kras/p53-driven lung tumors and to evaluate the combinatorial anti-tumor effect with MEK inhibitor (MEKi), trametinib, and immunomodulatory monoclonal antibodies (mAbs) targeting either programmed cell death protein-1 (PD-1) or programmed cell death protein ligand 1 (PD-L1) in vivo.

Experimental Design: Trp53;Kras;Rosa26 (PKL) genetically engineered mice were utilized to develop autochthonous lung tumors with intratracheal delivery of adenoviral Cre recombinase. Using these tumor-bearing lungs, tumor-infiltrating immune cells were characterized by both mass cytometry and flow cytometry. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.004DOI Listing
February 2019

[Indications and achievements of the extension assessment in breast cancer in France].

Gynecol Obstet Fertil Senol 2019 Feb 13. Epub 2019 Feb 13.

Institut Curie, INSERM U900, 35 Rue Dailly, 92210 Saint-Cloud, France; Institut Curie, Département de chirurgie oncologique, 35 Rue Dailly, 92210 Saint-Cloud, France. Electronic address:

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http://dx.doi.org/10.1016/j.gofs.2019.02.005DOI Listing
February 2019

Dual Effect of Doxazosin: Anticancer Activity on SH-SY5Y Neuroblastoma Cells and Neuroprotection on an In Vitro Model of Alzheimer's Disease.

Neuroscience 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Several studies have demonstrated the antitumor effect of doxazosin, an α1-adrenergic blocker, against glioma and breast, bladder and prostate cancers. Doxazosin is also being evaluated as a treatment for posttraumatic stress disorder and alcoholism, and α1-adrenergic blockers have been linked to neuroprotection in neurodegenerative disorders, such as Alzheimer's Disease (AD). Cancer and AD have an inverse relationship in many aspects, with several factors that contribute to apoptosis inhibition and proliferation being increased in cancers but decreased in AD. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.005DOI Listing
February 2019

BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment.

Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Tianjin Institute of Urology, Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China.

Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.005DOI Listing
February 2019

Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.

Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Royal Free Hospital, Centre for Rheumatology and Connective Tissue Diseases, UCL, London, UK. Electronic address:

Systemic sclerosis (SSc) is a systemic disease characterized by vasculopathy, progressive fibrosis and autoimmune activation. Tryptophan (Trp) metabolism has been linked to altered immune cell function and to malignancy. We have investigated the role of Trp metabolic pathway in SSc measuring serum Trp, Kynurenine (Kyn) and Trp/Kyn ratio in a cohort of 97 SSc patients and 10 healthy controls. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.009DOI Listing
February 2019

Reply.

Clin Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1016/j.cgh.2019.02.003DOI Listing
February 2019

Improved survival after cord blood transplantation: single center experience in pediatric patients over a two-decade period.

Biol Blood Marrow Transplant 2019 Feb 13. Epub 2019 Feb 13.

Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA; Department of Medicine, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.02.010DOI Listing
February 2019

Viral genome integration of canine papillomavirus 16.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer. In humans, this transformation most often occurs with high-risk papillomaviruses, where viral integration is a critical event in carcinogenesis. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.002DOI Listing
February 2019

Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

Computer-aided detection of mass in digital breast tomosynthesis using a faster region-based convolutional neural network.

Methods 2019 Feb 13. Epub 2019 Feb 13.

Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, High Education Zone, Hangzhou 310018, China. Electronic address:

Digital breast tomosynthesis (DBT) is a newly developed three-dimensional tomographic imaging modality in the field of breast cancer screening designed to alleviate the limitations of conventional digital mammography-based breast screening methods. A computer-aided detection (CAD) system was designed for masses in DBT using a faster region-based convolutional neural network (faster-RCNN). To this end, a data set was collected, including 89 patients with 105 masses. Read More

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http://dx.doi.org/10.1016/j.ymeth.2019.02.010DOI Listing
February 2019

The Trend, Feasibility, and Safety of Salpingectomy as a form of Permanent Sterilization.

J Minim Invasive Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics & Gynecology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston TX, USA.

Study Objectives: To assess the change in rate of laparoscopic salpingectomy for sterilization after the release of the November 2013 Society of Gynecologic Oncology (SGO) Clinical Practice Statement and the January 2015 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion: Salpingectomy for Ovarian Cancer Prevention. We hypothesized there would be an increase in salpingectomy as a percentage of total laparoscopic sterilizations performed without an increase in complications when compared to conventional bilateral tubal ligation (BTL).

Design: A retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.02.003DOI Listing
February 2019

Trends and Outcomes in Laparoscopic versus Open Surgery for Rectal Cancer from 2005 to 2016 Using the ACS-NSQIP Database, a Retrospective Cohort Study.

Int J Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Houston Methodist Hospital, Houston, TX, USA; Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address:

Background: There is controversy regarding the use of laparoscopy for rectal cancer, especially after the ACOSOG Z6051 Randomized Clinical Trial determined that laparoscopy failed to meet non-inferiority compared with open surgery. With these new recommendations, the current practices for the treatment of rectal cancer across the country are unknown.

Methods: Using the ACS-NSQIP database from 2005-2016, resections for rectal cancer were studied. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.006DOI Listing
February 2019

Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis.

Gene 2019 Feb 13. Epub 2019 Feb 13.

Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China. Electronic address:

Objective: This study aimed to investigate the biological role of C5orf34 in Lung adenocarcinoma (LAD) and the mechanism of such role.

Methods: The mRNA expression of C5orf34 was analyzed using student's t-test based on the data obtained from TCGA database. Kaplan-Meier analysis was performed to evaluate the prognosis value of C5orf34. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.019DOI Listing
February 2019

RLIP: An existential requirement for breast carcinogenesis.

Biochim Biophys Acta Rev Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Breast cancer (BC) is the most common cancer among women worldwide. Due to its complexity in nature, effective BC treatment can encounter many challenges. The human RALBP1 gene encodes a 76-kDa splice variant protein, RLIP (ral-binding protein1, RalBP1), a stress-protective mercapturic acid pathway (MAP) transporter protein, that also plays a key role in regulating clathrin-dependent endocytosis (CDE) as a Ral effector. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.001DOI Listing
February 2019

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

Effect of cancer history on post-resuscitation treatments in out-of-hospital cardiac arrest.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency Medicine, Seoul National University Hospital, Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. Electronic address:

Objectives: There is growing evidence that optimal post-resuscitation treatment is a significant factor for overall survival and neurological outcomes in out-of-hospital cardiac arrest (OHCA). However, there is also growing evidence of disparities in treatments in vulnerable populations such as elderly individuals or patients with underlying diseases, including cancer.

Aim: The aim of this study was to evaluate the influence of cancer status on post-resuscitation therapies among OHCA patients. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.005DOI Listing
February 2019

Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density.

Magn Reson Imaging 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address:

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.004DOI Listing
February 2019

Targeted demethylation of the SARI promotor impairs colon tumour growth.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, PR China. Electronic address:

SARI (suppressor of activator protein 1, regulated by IFN) functions as a tumour suppressor and is inactivated in various cancers. However, the mechanism underlying SARI inactivation in cancer remains elusive. In this study, we detected a high level of DNA methylation of the SARI promoter and an inverse correlation between SARI promoter methylation and expression in malignant tissues from patients with colon cancer. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.040DOI Listing
February 2019
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