3,849,031 results match your criteria Cancer prevention research Philadelphia Pa.[Journal]


Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, Amsterdam, The NetherlandsRadiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam.

Multimodality treatment has advanced the outcome of esophageal adenocarcinoma (EAC), but overall survival remains poor. Therapeutic pressure activates effective resistance mechanisms and we characterized these mechanisms in response to the currently used neoadjuvant treatment against EAC; carboplatin, paclitaxel and radiotherapy. We developed an in vitro approximation of this regimen and applied it to primary patient-derived cultures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32364DOI Listing

PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32366DOI Listing

NK and T cell subsets in malignant mesothelioma patients: baseline pattern and changes in the context of anti-CTLA-4 therapy.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK cell subsets and their recognition of mesothelioma cells remains to be explored. We used RNA expression data of MM biopsies derived from the cancer genome atlas to evaluate the immune cell infiltrates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32363DOI Listing

Fisetin and 5-Fluorouracil: Effective Combination for PIK3CA-Mutant Colorectal Cancer.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

The normal colon epithelium is transformed into its neoplastic counterpart through a series of genetic alterations in driver genes including activating mutations in PIK3CA. Treatment often involves surgery followed by 5-fluorouracil (5-FU) based therapy, which has limited efficiency and serious side effects. We sought to determine whether fisetin, a dietary flavonoid, alone or in combination with 5-FU affected tumorigenesis in the mammalian intestine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32367DOI Listing

MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and anti-metastatic properties in osteosarcoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School at Ein-Kerem, Jerusalem, Israel.

Osteosarcoma (OS) is an aggressive malignancy affecting mostly children and adolescents. MicroRNAs (miRNAs) play important roles in OS development and progression. Here we found that miR-16-1-3p and miR-16-2-3p "passenger" strands as well as the "lead" miR-16-5p strand are frequently downregulated and possess strong tumor suppressive functions in human OS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32368DOI Listing

A retrospective alternative for active surveillance trials for ductal carcinoma in situ of the breast.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of invasive breast cancer, accounting for twenty percent of screen-detected breast cancers. Little is known about the natural progression of DCIS, because most patients undergo surgery upon diagnosis. Many DCIS patients are likely being over-treated, as it is believed that only around fifty percent of DCIS will progress to invasive carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32362DOI Listing

Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32365DOI Listing

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.

In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32361DOI Listing

The Low-Cost, Long-Term Indwelling Pleural Catheter (LunGO): An Inexpensive and Effective Alternative for the Management of Dyspnea Associated with Malignant Pleural Effusions.

Respiration 2019 Apr 24:1-6. Epub 2019 Apr 24.

Thoracic Surgeon at Hospital Santa Marcelina de Itaquera, São Paulo, Brazil.

Background: A malignant pleural effusion (MPE) in patients with cancer is evidence of the underlying disease progression, resulting in many symptoms, and may lead to hospitalization. The treatment options include talc pleurodesis (TP) or the implantation of an indwelling pleural catheter. The costs of the latter approach are often seen to be inhibitive for the Brazilian and other emerging markets' public health system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498971DOI Listing

Pleural Cryobiopsy versus Flexible Forceps Biopsy in Subjects with Undiagnosed Exudative Pleural Effusions Undergoing Semirigid Thoracoscopy: A Crossover Randomized Trial (COFFEE Trial).

Respiration 2019 Apr 24:1-9. Epub 2019 Apr 24.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India,

Background: There is no randomized study comparing pleural cryobiopsy (CB) and flexible forceps biopsy (FFB) in subjects undergoing medical thoracoscopy for the diagnosis of pleural effusions.

Objective: In this crossover study, we compared the diagnostic yield of CB versus FFB in subjects undergoing semirigid thoracoscopy.

Methods: Subjects undergoing semirigid thoracoscopy for undiagnosed pleural effusions were subjected to both CB and FFB, with the order of performing the biopsy randomized in a 1:1 ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497212DOI Listing

Systemic Treatment Options for Carcinoid Syndrome: A Systematic Review.

Oncology 2019 Apr 24:1-17. Epub 2019 Apr 24.

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.

Background: Carcinoid syndrome symptoms significantly reduce quality of life in patients with neuroendocrine tumors. Evidence supporting the use of somatostatin analogues in carcinoid syndrome symptom control dates back 30 years. The introduction of new treatment options for carcinoid syndrome, such as telotristat ethyl in 2017, highlights the need for a review of high-level evidence of new and established systemic treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499049DOI Listing

PLAC8 is overexpressed and regulates cell proliferation in low-grade human PanNET.

Neuroendocrinology 2019 Apr 25. Epub 2019 Apr 25.


Background/Aims: Many aspects of the biology of pancreatic neuroendocrine tumors (PanNETs), including determinants of proliferative, invasive and metastatic potential, remain poorly understood. Placenta-specific 8 (PLAC8), a gene with unknown molecular function, has been reported to have tumor-promoting roles in different human malignancies, including exocrine pancreatic cancer. Since preliminary data suggested deregulation of PLAC8 expression in PanNET, we have performed detailed analyses of PLAC8 expression and function in human PanNET. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500541DOI Listing

Dosimetric impact of esophagus motion in single fraction spine stereotactic body radiotherapy.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, UNITED STATES.

Nine patients with single fraction spinal stereotactic body radiation therapy (SBRT) treatment were identified to assess both the intra fraction and daily esophageal motion and associated dosimetric deviation in spinal SBRT. We performed a chained deformable registration of 4-D CT phase images to estimate the intra fraction motion magnitude of the esophagus in a breathing cycle. The intra fraction esophageal motion mostly exhibited in the superior-inferior direction with the total motion magnitude increased from the T1 (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab1c2bDOI Listing

Parameterizing and validating existing algorithms for identifying out-of-bed time using hip-worn accelerometer data from older women.

Physiol Meas 2019 Apr 24. Epub 2019 Apr 24.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, UNITED STATES.

Objective: To parameterize and validate two existing algorithms for identifying out-of-bed time using 24-hour hip-worn accelerometer data from older women. 
 
 Approach: Overall, 628 women (80±6 years old) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to 7 days and concurrently completed sleep-logs. Trained staff used a validated visual analysis protocol to measure in-bed periods on accelerometer tracings (criterion). Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6579/ab1c04
Publisher Site
http://dx.doi.org/10.1088/1361-6579/ab1c04DOI Listing
April 2019
1 Read

Lobectomy in patients with differentiated thyroid cancer: indications and follow-up.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

J Yoon, Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea (the Republic of).

The extent of thyroid surgery for patients with low- and intermediate-risk differentiated thyroid carcinoma (DTC), with a primary tumour <4 cm and no extrathyroidal extension (ETE) or lymph node (LN) metastases, has shifted in a more conservative direction. However, clinicopathological risk factors, including microscopic ETE, aggressive histology, vascular invasion in papillary thyroid carcinoma (PTC), and intermediate volume of LN metastases, can only be identified after completing thyroid lobectomy. It is controversial whether patients with these risk factors should immediately undergo complete thyroidectomy and/or radioactive iodine remnant ablation, or should be monitored without further treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-19-0085DOI Listing

Impact of Adjuvant Chemotherapy on Oncologic Outcomes following Radical Nephroureterectomy for Patients with pT3NanyM0 Upper Tract Urothelial Carcinoma: A retrospective cohort study.

Int J Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:

Objective: We investigated the impact of cisplatin-based adjuvant chemotherapy (AC) on oncologic outcomes including recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) after radical nephroureterectomy (RNU) for patients with pT3NanyM0 upper tract urothelial carcinoma (UTUC).

Methods: We retrospectively reviewed 293 patients who underwent RNU for UTUC between 1995 and 2017. Clinicopathologic characteristics of patients were examined and compared according to the use of AC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijsu.2019.04.013DOI Listing

FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer.

Cancer Lett 2019 Apr 21. Epub 2019 Apr 21.

Department of Ultrasound Medicine, Tang Du Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China. Electronic address:

Early accurate diagnosis and targeted therapy for cancer are essential to improve the prognosis of patients. With the emergence of molecular imaging, molecule-targeted ultrasound imaging for the non-invasive and precise detection of cancer has attracted increased attention. The investigation of molecule-targeted ultrasound contrast agents (UCAs) with excellent performance is urgently needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2019.04.023DOI Listing

Chemical composition and cytotoxic screening of Musa cavendish green peels extract: Antiproliferative activity by activation of different cellular death types.

Toxicol In Vitro 2019 Apr 21. Epub 2019 Apr 21.

Emergency Medicine Department, Medical School, University of São Paulo, Av. Dr. Arnaldo, 455 - Cerqueira César, São Paulo, São Paulo CEP 01246-903, Brazil.

Musa cavendish, commonly known as banana, is a fruit with nutritional and therapeutic properties. We investigated the chemical composition and in vitro cytotoxic effect of M. cavendish green peel extract (MHE) on cancer cells for the first time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2019.04.020DOI Listing

Notch Signaling Mediates Secondary Senescence.

Cell Rep 2019 Apr;27(4):997-1007.e5

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address:

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.104DOI Listing

The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells.

Cell Rep 2019 Apr;27(4):987-996.e3

Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address:

Mutations of the Integrator subunits are associated with neurodevelopmental disorders and cancers. However, their role during neural development is poorly understood. Here, we demonstrate that the Drosophila Integrator complex prevents dedifferentiation of intermediate neural progenitors (INPs) during neural stem cell (neuroblast) lineage development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.089DOI Listing

Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis.

Cell Rep 2019 Apr;27(4):1277-1292.e7

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based approach, which leverages the transcriptome of xenografts and distinguishes tumor cell and stromal gene expression with improved sensitivity and accuracy. Our data reveal shifts in epithelial and neuronal-like lineage programs in malignant cells as they adapt to the brain TME and the reciprocal neuroinflammatory response of the stroma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.085DOI Listing

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.

Cell Rep 2019 Apr;27(4):1265-1276.e4

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. These organoids derived from BTCs were cultured stably for >1 year and closely recapitulated the histopathology, gene expression, and genetic alterations evident in the primary tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.088DOI Listing

In Situ Modification of Tissue Stem and Progenitor Cell Genomes.

Cell Rep 2019 Apr;27(4):1254-1264.e7

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address:

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, we use a sensitive Cre/lox fluorescent reporter system to test the efficiency of genome modification following in vivo transduction by adeno-associated viruses (AAVs) in tissue stem and progenitor cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.105DOI Listing

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.

Cell Rep 2019 Apr;27(4):1176-1189.e5

State Key Laboratory of Cell Biology, Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Innovation Center for Cell Signaling Network, Shanghai 200031, China. Electronic address:

Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial homeostasis are critical for the pathological processes associated with inflammatory bowel disease (IBD). YAP (Yes-associated protein) is a key component of the Hippo pathway and was recently suggested to promote epithelial cell regeneration for IBD recovery. However, it is unclear how YAP regulates macrophage polarization, inflammation, and gut microbial homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.028DOI Listing

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

Cell Rep 2019 Apr;27(4):1165-1175.e5

Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a mechanism for how STING balances activation of IRF3- and NF-κB-dependent transcription and discover that acquisition of discrete signaling modules in the vertebrate STING C-terminal tail (CTT) shapes downstream immunity. As a defining example, we identify a motif appended to the CTT of zebrafish STING that inverts the typical vertebrate signaling response and results in dramatic NF-κB activation and weak IRF3-interferon signaling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.098DOI Listing

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D.

Cell Rep 2019 Apr;27(4):1151-1164.e5

Department of Biology, Tufts University, Suite 4700, 200 Boston Ave., Medford, MA 02155, USA; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA. Electronic address:

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cells. Flex1 fragility is dependent on the ability of a variable-length AT repeat to form a cruciform structure that stalls replication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.103DOI Listing

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination.

Cell Rep 2019 Apr;27(4):1090-1102.e10

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden; Ming Wai Lau Centre for Reparative Medicine, Stockholm Node, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address:

Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.03.108DOI Listing

Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
1 Read

Companion diagnostic tests for treatment of lung cancer patients: what are the current and future challenges?

Expert Rev Mol Diagn 2019 Apr 24. Epub 2019 Apr 24.

b Aix Marseille University , CRCM, INSERM, CNRS, AP-HM, Multidisciplinary Oncology and Therapeutic Innovations Department , Chemin des Bourrely, 13015 , Marseille , France .

Introduction: Companion diagnostic tests (CDXs) are considered mandatory for decision making for treatment with targeted therapies in thoracic oncology. The emergence of immunotherapy has also given rise to the development of CDXs. Some CDXs, in particular PD-L1 immunohistochemistry tests, have been questioned and re-examined for use with new combination therapies that are being evaluated in clinical trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737159.2019.1611426DOI Listing

Gold Cube-in-Cube Based Oxygen Nanogenerator: A Theranostic Nanoplatform for Modulating Tumor Microenvironment for Precise Chemo-Phototherapy and Multimodal Imaging.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Engineering a versatile oncotherapy nanoplatform integrating both diagnostic and therapeutic functions has always been an intractable challenge in targeted cancer treatment. Herein, to actualize the theme of precise medicine, a nanoplatform is developed by anchoring Mn-Cdots to doxorubicin (DOX)-loaded mesoporous silica-coated gold cube-in-cubes core/shell nanocomposites and further conjugating them to a Arg-Gly-Asp (RGD) peptide (denoted as RGD-CCmMC/DOX) to achieve active-targeting effect. Under a 635 nm irradiation, the nanoplatform acts as oxygen nanogenerator that produces O2 in situ and amplifies the content of singlet oxygen (1O2) in the hypoxic tumor microenvironment (TME), which has been demonstrated to attenuate tumor hypoxia and synchronously enhance photodynamic efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.8b09786DOI Listing
April 2019
1 Read

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer. Reply.

N Engl J Med 2019 Apr;380(17):e28

Université de Lille, Lille, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1901650DOI Listing

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

N Engl J Med 2019 Apr;380(17):e28

University of Athens Medical School, Athens, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1901650DOI Listing

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

N Engl J Med 2019 Apr;380(17):e28

Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1901650DOI Listing

Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm.

N Engl J Med 2019 Apr;380(17):1628-1637

From the University of Texas M.D. Anderson Cancer Center, Houston (N.P., M.D., H.M.K., M.K.); Dana-Farber Cancer Institute (A.A.L.) and Boston University School of Medicine (J.M.S.), Boston, and Veristat, Southborough (J.B.) - all in Massachusetts; H. Lee Moffitt Cancer Center, Tampa, FL (K.L.S., J.E.L.); City of Hope National Medical Center, Duarte, CA (A.S.S.); Ohio State University, Columbus (S.V.); Winship Cancer Institute of Emory University, Atlanta (W.B.); Duke University Medical Center, Durham, NC (D.A.R.); and Roswell Park Comprehensive Cancer Center, Buffalo (E.S.W.), and Stemline Therapeutics, New York (S. Spence, S. Shemesh, C.L.B., I.B.) - both in New York.

Background: Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an aggressive hematologic cancer that is caused by transformed plasmacytoid dendritic cells that overexpress interleukin-3 receptor subunit alpha (IL3RA or CD123). Tagraxofusp (SL-401) is a CD123-directed cytotoxin consisting of human interleukin-3 fused to truncated diphtheria toxin.

Methods: In this open-label, multicohort study, we assigned 47 patients with untreated or relapsed BPDCN to receive an intravenous infusion of tagraxofusp at a dose of 7 μg or 12 μg per kilogram of body weight on days 1 to 5 of each 21-day cycle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1815105DOI Listing

The ROC Curve Redefined - Optimizing Sensitivity (and Specificity) to the Lived Reality of Cancer.

Authors:
Susan P Walker

N Engl J Med 2019 Apr;380(17):1594-1595

From the Department of Obstetrics and Gynaecology, University of Melbourne; and Mercy Hospital for Women - both in Melbourne, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMp1814951DOI Listing

A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value.

FEBS J 2019 Apr 24. Epub 2019 Apr 24.

Biochemistry, Biochemical Analysis& Matrix Pathobiochemistry Research Group, Department of Chemistry, University of Patras, 26504, Patras, Greece.

Hyaluronan is a unique non-sulfated glycosaminoglycan that contributes to breast cancer cells growth and functional properties, including cell migration, invasion, adhesion, as well as tumor-associated angiogenesis in different stages of breast cancer progression and especially metastasis. Latest data show that the levels of hyaluronan and/or low molecular mass hyaluronan in blood serum and plasma of breast cancer patients may be a useful biomarker for breast cancer prognosis, differential diagnosis and patients' treatment monitoring. Therefore, the qualitative and quantitative determination of hyaluronan in biological samples is an emerging area of research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.14860DOI Listing

Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma.

Small 2019 Apr 24:e1900157. Epub 2019 Apr 24.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.

Tumor metastasis is considered a major cause of cancer-related human mortalities. However, it still remains a formidable challenge in clinics. Herein, a bioinspired multivalent nanoplatform for the highly effective treatment of the metastatic melanoma is reported. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019001
Publisher Site
http://dx.doi.org/10.1002/smll.201900157DOI Listing
April 2019
1 Read

Scissor haemorrhoidectomy under perineal anaesthetic infiltration as a day case procedure - video vignette.

Colorectal Dis 2019 Apr 24. Epub 2019 Apr 24.

Departament of Surgical oncology, Institute of Oncology, Vilnius University, Clinic of Internal, Family Medicine and Oncology, Faculty of Medicine, Vilnius, Lithuania.

Hemorrhoids are common anorectal disease [1]. Patients with Grade III-IV prolapsed hemorrhoids or after failed conservative are considered for excisional hemorrhoidectomy. Surgical technique At our department all patients with Grade III or IV symptomatic hemorrhoids undergo closed (as described by Fergusson) scissor hemorrhoidectomy under perineal anesthetic infiltration [2], with removal of the two classical piles at 3 and 11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/codi.14656DOI Listing

Heterozygosity mapping for human dominant trait variants.

Hum Mutat 2019 Apr 24. Epub 2019 Apr 24.

Laboratory of Statistical Genetics, Rockefeller University, New York, New York.

Homozygosity mapping is a well-known technique to identify runs of homozygous variants that are likely to harbor genes responsible for autosomal recessive disease, but a comparable method for autosomal dominant traits has been lacking. We developed an approach to map dominant disease genes based on heterozygosity frequencies of sequence variants in the immediate vicinity of a dominant trait. We demonstrate through theoretical analysis that DNA variants surrounding an inherited dominant disease variant tend to have increased heterozygosity compared with variants elsewhere in the genome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.23765DOI Listing

Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides.

Adv Mater 2019 Apr 24:e1805798. Epub 2019 Apr 24.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, National Institute for Advanced Materials, and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.

Self-assembly is a powerful tool for constructing supramolecular materials for many applications, ranging from energy harvesting to biomedicine. Among the methods to prepare supramolecular materials for biomedical applications, enzyme-instructed self-assembly (EISA) has several advantages. Herein, the unique properties and advantages of EISA in preparing biofunctional supramolecular nanomaterials and hydrogels from peptides are highlighted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201805798DOI Listing

Differential tissue expression of extracellular vesicle-derived proteins in prostate cancer.

Prostate 2019 Apr 24. Epub 2019 Apr 24.

Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands.

Background: Proteomic profiling of extracellular vesicles (EVs) from prostate cancer (PCa) and normal prostate cell lines, led to the identification of new candidate PCa markers. These proteins included the nuclear exportin proteins XPO1 (also known as CRM1), the EV-associated PDCD6IP (also known as ALIX), and the previously published fatty acid synthase FASN. In this study, we investigated differences in expression of XPO1 and PDCD6IP on well-characterized prostate cancer cohorts using mass spectrometry and tissue microarray (TMA) immunohistochemistry to determine their diagnostic and prognostic value. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.23813DOI Listing

Infiltrating CD4+ T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling.

Prostate 2019 Apr 24. Epub 2019 Apr 24.

Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing, China.

Background: Chemotherapy with Docetaxel (Doc) is efficient in a subset of prostate cancer (PCa) cases; however, most patients ultimately develop resistance to Docetaxel. The tumor immune microenvironment and secreted cytokines play a substantial role in development of resistance to chemotherapy. Our previous study has demonstrated that CD4+ T cells in prostate tumor microenvironment contribute to PCa progression; meanwhile, we found increased CD4+ T-cell infiltration in tumor area after Doc treatment; however, their effects on PCa chemosensitivity remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.23810DOI Listing

p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress.

PLoS Pathog 2019 Apr 24;15(4):e1007541. Epub 2019 Apr 24.

Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States of America.

DNA damage response (DDR) and selective autophagy both can be activated by reactive oxygen/nitrogen species (ROS/RNS), and both are of paramount importance in cancer development. The selective autophagy receptor and ubiquitin (Ub) sensor p62 plays a key role in their crosstalk. ROS production has been well documented in latent infection of oncogenic viruses including Epstein-Barr Virus (EBV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007541DOI Listing

Correlates of hospitalizations in internal medicine divisions among Israeli adults of different ethnic groups with hypertension, diabetes and cardiovascular diseases.

PLoS One 2019 24;14(4):e0215639. Epub 2019 Apr 24.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.

Background: Disparities in non-communicable diseases (NCDs) may affect health care utilization. We compared the correlates of hospitalizations in internal medicine divisions, of adults with NCDs, between the main population groups in Israel.

Methods: A cross-sectional study was conducted among Jews (N = 17,952) and Arabs (N = 10,441) aged ≥40 years with diabetes, hypertension or cardiovascular diseases, utilizing the computerized database of the largest health maintenance organization in Israel. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215639PLOS

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS One 2019 24;14(4):e0215905. Epub 2019 Apr 24.

Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America.

The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. HERG channels are also expressed in a variety of cancer cells and control cell proliferation and apoptosis. Hypoxia, a common feature of tumors, alters gating properties of hERG currents in SH-SY5Y neuroblastoma cells. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215905PLOS

Mentoring stages: A study of undergraduate mentoring in palliative medicine in Singapore.

PLoS One 2019 24;14(4):e0214643. Epub 2019 Apr 24.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

Background: Mentoring nurtures a mentee's personal and professional development. Yet conflation of mentoring approaches and a failure to contend with mentoring's nature makes it difficult to study mentoring processes and relationships. This study aims to understand of mentee experiences in the Palliative Medicine Initiative (PMI). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214643PLOS

Mutational landscape of canine B-cell lymphoma profiled at single nucleotide resolution by RNA-seq.

PLoS One 2019 24;14(4):e0215154. Epub 2019 Apr 24.

Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Padua, Italy.

The genomic landscape in human B-cell lymphoma has revealed several somatic mutations and potentially relevant germline alterations affecting therapy and prognosis. Also, mutations originally described as somatic aberrations have been shown to confer cancer predisposition when occurring in the germline. The relevance of mutations in canine B-cell lymphoma is scarcely known and gene expression profiling has shown similar molecular signatures among different B-cell histotypes, suggesting other biological mechanisms underlining differences. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215154PLOS

Perinatal hepatitis B virus transmission in Lao PDR: A prospective cohort study.

PLoS One 2019 24;14(4):e0215011. Epub 2019 Apr 24.

Institut de recherche pour le développement (IRD, France), PHPT, Changklan, Muang, Chiang Mai, Thailand.

Background: Mother-to-child transmission of hepatitis B virus (HBV) is the main cause of new infections worldwide. We aimed at assessing the percentage of infants successfully immunized in two major hospitals in Vientiane, Lao PDR where HB immune globulin (HBIg) is not available.

Methods: We studied a prospective cohort of chronically HBV infected pregnant women and their infants until 6 months post-partum from January 2015 to March 2017. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215011PLOS

TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria.

PLoS Biol 2019 Apr 24;17(4):e3000209. Epub 2019 Apr 24.

Institut Curie, Centre de Recherche, PSL Research University, Paris, France.

Gram+ infections are worldwide life-threatening diseases in which the pathological role of type I interferon (IFN) has been highlighted. Plasmacytoid predendritic cells (pDCs) produce high amounts of type I IFN following viral sensing. Despite studies suggesting that pDCs respond to bacteria, the mechanisms underlying bacterial sensing in pDCs are unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.3000209DOI Listing

CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.

PLoS Genet 2019 Apr 24;15(4):e1008034. Epub 2019 Apr 24.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large number of differentiated melanocytes during each HF cycle. HF McSCs reside in both the CD34+ bulge/lower permanent portion (LPP) and the CD34- secondary hair germ (SHG) regions of the HF during telogen. Using Dct-H2BGFP mice, we separate bulge/LPP and SHG McSCs using FACS with GFP and anti-CD34 to show that these two subsets of McSCs are functionally distinct. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pgen.1008034
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.1008034DOI Listing
April 2019
1 Read
  • Page 1 of 76981