4,113,130 results match your criteria Cancer microenvironment : official journal of the International Cancer Microenvironment Society[Journal]


Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors.

J Leukoc Biol 2020 Jul 3. Epub 2020 Jul 3.

Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.

Innovative immunotherapies based on immune checkpoint targeting antibodies and engineered T cells are transforming the way we approach cancer treatment. However, although these T cell centered strategies result in marked and durable responses in patients across many different tumor types, they provide therapeutic efficacy only in a proportion of patients. A major challenge of immuno-oncology is thereby to identify mechanisms responsible for resistance to cancer immunotherapy in order to overcome them via adapted strategies that will ultimately improve intrinsic efficacy and response rates. Read More

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http://dx.doi.org/10.1002/JLB.1MR0520-746RDOI Listing

Anti-CD20 rituximab IgG1, IgG3, and IgG4 but not IgG2 subclass trigger Ca mobilization and cytotoxicity in human NK cells.

J Leukoc Biol 2020 Jul 3. Epub 2020 Jul 3.

Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.

NK cell-mediated Ab-dependent cellular cytotoxicity (ADCC) is increasingly recognized to play an important role in cancer immunotherapy, transplant rejection, and autoimmunity. However, several aspects of the molecular interactions of IgG subclasses with the Fc-gamma receptor IIIA (FcγRIIIA)/CD16a expressed on NK cells remain unknown. The aim of the current study was to further analyze the role of IgG subclasses and FCGR3A V158F single nucleotide polymorphism (SNP) on Ca signaling and NK cell-mediated ADCC against Daudi target cells in vitro. Read More

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http://dx.doi.org/10.1002/JLB.5MA0620-039RDOI Listing

Identification of the association between HBcAg-specific T cell and viral control in chronic HBV infection using a cultured ELISPOT assay.

J Leukoc Biol 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Hepatitis B virus (HBV)-specific T cells play a critical role in determining the outcome of HBV infection. However, T cell response induced by predominant Ag in chronic infection is hardly detectable owing to the lack of a suitable assay. We herein established an optimized method to enumerate HBV-specific T cells and assessed the association between HBV surface Ag (HBsAg) and HBV DNA. Read More

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http://dx.doi.org/10.1002/JLB.5MA0620-023RRDOI Listing

A new intracorporeal suture-less stapled end-to-end anastomosis in laparoscopic left-colectomy for colon cancer- a video vignette.

Colorectal Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

In many retrospective studies and two randomized controlled trials, intracorporeal anastomosis in laparoscopic colon cancer surgery compared with extracorporeal anastomosis has shown advantages such as less pain due to decreased wound length, earlier recovery of postoperative bowel function and reduced short-term morbidity. Intracorporeal anastomosis is a widely performed procedure in laparoscopic and robotic surgery in the world. Read More

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http://dx.doi.org/10.1111/codi.15232DOI Listing

Salivary Biomarker Profiles in E-Cigarette Users and Conventional Smokers: A Cross-Sectional Study.

Oral Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, 21201, USA.

The alterations in host immune response and the release of pro-inflammatory cytokines are well documented in cigarette smokers. The harmful effects of e-cigarettes and on how they pertain to the host immune response are largely unknown. This pilot cross-sectional study was conducted at the University of Maryland School of Dentistry. Read More

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http://dx.doi.org/10.1111/odi.13533DOI Listing

Laparoscopic excision of a cystic vascular malformation of the sigmoid colon mesentery presenting as a retroperitoneal tumour - a video vignette.

Colorectal Dis 2020 Jul 3. Epub 2020 Jul 3.

Klaipeda University Hospital, Klaipeda, Lithuania.

Mesenteric tumours are quite rare and form a heterogeneous group of tumours. Most of the time they are found accidently on computed tomography (CT) causing only vague abdominal symptoms. These tumours can arise from any of the mesenteric components: vessels, peritoneum, lymphatic tissue, fat, and connective tissue [1]. Read More

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http://dx.doi.org/10.1111/codi.15230DOI Listing

The utility of brain biopsy in pediatric cryptogenic neurological disease.

J Neurosurg Pediatr 2020 Jul 3:1-8. Epub 2020 Jul 3.

Departments of1Neurosurgery.

Objective: The authors' aim was to characterize a single-center experience of brain biopsy in pediatric cryptogenic neurological disease.

Methods: The authors performed a retrospective review of consecutive brain biopsies at a tertiary pediatric neurosciences unit between 1997 and 2017. Children < 18 years undergoing biopsy for neurological pathology were included. Read More

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http://dx.doi.org/10.3171/2020.4.PEDS19783DOI Listing

Radiographic and clinical outcomes using intraoperative magnetic resonance imaging for transsphenoidal resection of pituitary adenomas.

J Neurosurg 2020 Jul 3:1-12. Epub 2020 Jul 3.

Departments of2Neurosurgery.

Objective: The utility and safety of intraoperative MRI (iMRI) for resection of pituitary adenomas is not clearly established in the context of advances in endoscopic approaches. The goal in this study was to evaluate the safety and efficacy of iMRI for pituitary adenoma resection, with endoscopic transsphenoidal (ETS) versus microscopic transsphenoidal (MTS) approaches.

Methods: Radiographic and clinical outcomes of all pituitary adenomas resected using iMRI between 2008 and 2017 at a single institution were retrospectively evaluated. Read More

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http://dx.doi.org/10.3171/2020.4.JNS20178DOI Listing

Development of an immune gene prognostic classifier for survival prediction and respond to immunocheckpoint inhibitor therapy/chemotherapy in endometrial cancer.

Int Immunopharmacol 2020 Jun 30;86:106735. Epub 2020 Jun 30.

Department of Gynecology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China. Electronic address:

Immunotherapy has provided a promising therapeutic strategy for endometrial cancer (EC). The present study aims to develop a prognostic classifier based on immune-related genes (IRGs) to stratify EC patients. A total of 15 prognosis-related IRGs were further filtrated by multivariate Cox regression: LTA, TMSB15A, S100A14, PLA2G2A, PDGFRA, CLDN4, CTF1, PRLH, PTN, SST, HTR3E, NRP1, RORA, THRA and CBLC. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106735DOI Listing

Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy.

Curr Opin Pharmacol 2020 Jun 30;54:1-10. Epub 2020 Jun 30.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, SAR, China; Department of Thoracic Surgery, Guangzhou Institute of Respiratory Health and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China. Electronic address:

Immune checkpoint blockade therapies that target CTLA-4 and PD-1/PD-L1 have ushered in a new era of cancer treatment. Nevertheless, a significant proportion of patients demonstrated primary or acquired resistance. Harnessing gut microbiota has been an emerging novel therapeutic strategy to overcome resistance. Read More

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http://dx.doi.org/10.1016/j.coph.2020.06.004DOI Listing

Transoral thyroidectomy (TOETVA): Complications, surgical time and learning curve.

Oral Oncol 2020 Jun 30;110:104871. Epub 2020 Jun 30.

Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, Sao Paulo, Brazil; Head and Neck Surgery, University of São Paulo Medical School, Sao Paulo, Brazil.

Background: Since 2018, transoral endoscopic thyroidectomy vestibular approach (TOETVA) has emerged as a true scarless thyroid surgery. In this study, we explore early outcomes and learning curve of this new approach.

Methods: A retrospective cohort including conventional thyroidectomies and TOETVAs performed in a cancer center was designed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104871DOI Listing

Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma.

Oral Oncol 2020 Jun 30;110:104877. Epub 2020 Jun 30.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Purpose: To identify whether radiomic features from pre-treatment computed tomography (CT) scans can predict molecular differences between head and neck squamous cell carcinoma (HNSCC) using The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA).

Methods: 77 patients from the TCIA with HNSCC had imaging suitable for analysis. Radiomic features were extracted and unsupervised consensus clustering was performed to identify subtypes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104877DOI Listing

Clinicopathological features of 50 mismatch repair (MMR)-deficient endometrial carcinomas, tested by immunohistochemistry: A single institutional feasibility study, India.

Ann Diagn Pathol 2020 Jun 20;47:151558. Epub 2020 Jun 20.

Department of Radiation Oncology (Gynecology, Disease Management group), Tata Memorial Hospital, HBNI University, Mumbai, India.

There are few comprehensive studies from Asia on clinicopathologic features of mismatch repair (MMR)-deficient endometrial carcinomas, including rarely from our country. One hundred and four cases of endometrial carcinomas were tested for four MMR proteins by immunohistochemistry. Among 50 MMR-deficient (MMRd) tumors(48%), age-range was 27-68 years(median = 53) and tumor size(n = 34) varied from 1. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151558DOI Listing

Fine particulate matter constituents and cause-specific mortality in China: A nationwide modelling study.

Environ Int 2020 Jun 30;143:105927. Epub 2020 Jun 30.

Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou 511443, China; JNU-QUT Joint Laboratory for Air Quality Science and Management, Jinan University, Guangzhou 511443, China. Electronic address:

Background: Fine particulate matter (with aerodynamic diameter ≤2.5 µm, PM) causes huge disease burden worldwide. However, evidence is still inadequate and inconsistent on the relationships between PM constituents and mortality, especially in low resource settings. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105927DOI Listing

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity.

J Inorg Biochem 2020 Jun 20;210:111133. Epub 2020 Jun 20.

Departamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil. Electronic address:

Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promotion of angiogenic activity by NO compared to HNO, which blocks neovascularization. While many NO donors have been developed over the years, interest in HNO has led to the recent emergence of new donors. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111133DOI Listing

Drug repurposing: Discovery of troxipide analogs as potent antitumor agents.

Eur J Med Chem 2020 Jun 26;202:112471. Epub 2020 Jun 26.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clinical drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three cancer cell lines and WPMY-1. Compound 5q, especially, could effectively inhibit PC3 with an IC value of 0. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112471DOI Listing

Could anti-CD20 therapy jeopardise the efficacy of a SARS-CoV-2 vaccine?

Eur J Cancer 2020 Jun 25;136:4-6. Epub 2020 Jun 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

A vaccine against SARS-CoV-2 might represent the most promising approach to halt durably the current COVID-19 pandemic. We believe that anti-CD20 therapy may jeopardise the efficacy of such a vaccine. This is regrettable because patients receiving anti-CD20 therapy (i. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.06.017DOI Listing

The feasibility and usability of DNA-dot bioconjugation to antibody for targeted in vitro cancer cell fluorescence imaging.

J Photochem Photobiol B 2020 Jun 26;209:111944. Epub 2020 Jun 26.

Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

DNA-protein bioconjugation is an appealing target-tracking strategy. The new capability of DNA molecule as a biological nanomaterial endows unique fluorescence and physicochemical properties to be applied in bioimaging. Progression in targeted imaging is contingent on the conjugation of diagnostic nanoparticles to biomolecular signatures, particularly antibody-based ligands. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111944DOI Listing

Isolated limb perfusion for soft tissue sarcoma: Current practices and future directions. A survey of experts and a review of literature.

Cancer Treat Rev 2020 Jun 19;88:102058. Epub 2020 Jun 19.

Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Soft tissue sarcomas constitute 1% of adult malignant tumors. They are a heterogeneous group of more than 50 different histologic types. Isolated limb perfusion is an established treatment strategy for locally advanced sarcomas. Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102058DOI Listing

Dedifferentiated melanomas: Morpho-phenotypic profile, genetic reprogramming and clinical implications.

Cancer Treat Rev 2020 Jun 23;88:102060. Epub 2020 Jun 23.

Unit of Melanoma, Division of Medical Oncology, Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy. Electronic address:

Phenotypic plasticity of malignant melanoma is a well-known phenomenon. Several translational studies and small case series have reported this clinical and biological entity, particularly in metastatic melanoma, showing frequent aberrant expression of non-melanocytic differentiation markers of different lineages, posing remarkable challenges due to several alternative differential diagnoses including undifferentiated carcinoma and sarcomas. When melanoma loses its typical morpho-phenotype by routinely used diagnostic immunohistochemical markers, it is defined as "dedifferentiated melanoma". Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102060DOI Listing

Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.

Cancer Treat Res Commun 2020 Jun 27;24:100187. Epub 2020 Jun 27.

Department of Oncology, Rigshospitalet, Copenhagen, Denmark.

Background: Chemoradiotherapy is standard treatment for localized oesophageal cancer unsuitable for surgery. We aimed to evaluate the efficacy of cetuximab in combination with chemoradiotherapy.

Methods: This non-randomised multicentre phase II trial recruited patients aged 18-75 with WHO performance status 0-2 having squamous cell carcinoma or adenocarcinoma in the oesophagus or gastro-oesophageal junction, T2-4, N0-3, M0 not suitable for surgery. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100187DOI Listing

Antibody selection influences the detection of AR-V7 in primary prostate cancer.

Cancer Treat Res Commun 2020 Jun 23;24:100186. Epub 2020 Jun 23.

Molecular Urooncology, Department of Urology, University Hospital Heidelberg, Im Neuenheimer Feld 517, Heidelberg, D-69120, Germany; Department of Urology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 110, Heidelberg, D-69120, Germany. Electronic address:

Background: The androgen receptor (AR) splice variant V7 (AR-V7) is an emerging marker to aid clinical decision-making in patients with castration-resistant prostate cancer (CRPC). A number of studies have shown that a subset of patients also express AR-V7 in the primary tumor. These findings have recently been challenged by a study showing that AR-V7 becomes only detectable in CRPC but is virtually absent in castration-naïve prostate cancer. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100186DOI Listing

Safety and efficacy of T-DM1 in patients with advanced HER2-positive breast cancer The Royal Marsden experience.

Cancer Treat Res Commun 2020 Jun 27;24:100188. Epub 2020 Jun 27.

Medical Oncology, Royal Marsden Hospital, Royal Marsden Hospital, Downs Road, Sutton SM25PT, United Kingdom. Electronic address:

Background: Ado-trastuzumab emtansine (T-DM1) is standard of care for patients with advanced HER2+ breast cancer who relapse within 6 months of adjuvant trastuzumab or progress on first-line anti-HER2 therapy. We evaluated its safety and efficacy in our real-world population.

Methods: We identified patients on T-DM1 from 01/01/2014 to 12/03/2018 from our electronic records. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100188DOI Listing

S2 Subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study.

Transl Oncol 2020 Jun 29;13(10):100814. Epub 2020 Jun 29.

University of Pittsburgh, Pittsburgh, PA-15213, USA. Electronic address:

Novel coronavirus disease 2019 (COVID-19) is the biggest threat to human being globally. The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it has spread in more than 200 countries. COVID-19 is more lethal in the elderly and people with an underlying condition such as asthma, cancer, diabetes. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100814DOI Listing

The questionable efficacy of manualized psychological treatments for distressed breast cancer patients: An individual patient data meta-analysis.

Clin Psychol Rev 2020 Jun 16;80:101883. Epub 2020 Jun 16.

Department of Psychological Sciences, University of Liverpool, Whelan Building, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.

Previous meta-analyses conclude that psychological treatments are efficacious for emotional distress in breast cancer (BCa). However, the practical relevance of these meta-analyses is questionable; none focused specifically on clinically distressed patients or whether treatment effects were clinically significant. In a two-stage individual patient data (IPD) meta-analysis of 17 randomized controlled trials of manualized psychological treatments in BCa, we evaluated treatment efficacy in distressed BCa patients (n = 1591) using clinical significance and effect size analyses. Read More

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http://dx.doi.org/10.1016/j.cpr.2020.101883DOI Listing

IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8 T cells in high dimensional analysis.

Cell Immunol 2020 Jun 24;355:104155. Epub 2020 Jun 24.

Departments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

The IL-7 receptor alpha chain (IL-7Rα or CD127) can be differentially expressed in memory CD8 T cells. Here we investigated whether IL-7Rα could serve as a key molecule in defining a comprehensive landscape of heterogeneity in human effector memory (EM) CD8 T cells using high-dimensional Cytometry by Time-Of-Flight (CyTOF) and single-cell RNA-seq (scRNA-seq). IL-7Rα had diverse, but organized, expressional relationship in EM CD8 T cells with molecules related to cell function and gene regulation, which rendered an immune landscape defining heterogeneous cell subsets. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104155DOI Listing

Evolution of histomorphologic, cytogenetic, and genetic abnormalities in an untreated patient with MIRAGE syndrome.

Cancer Genet 2020 Jun 14;245:42-48. Epub 2020 Jun 14.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Abramson Research Center, Room 716D, 3615 Civic Center Blvd., Philadelphia, PA 19104, United States; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

Gain of function variants in SAMD9 cause MIRAGE syndrome, a rare Mendelian disorder that results in myeloid dysplastic syndrome (MDS), poor immune response, restricted growth, adrenal insufficiency, ambiguous genitalia, feeding difficulties and most often significantly reduced lifespan. In this study, we describe histomorphologic and genetic changes occurring in serial bone marrow measurements in a patient with MIRAGE syndrome and untreated MDS of 9 years. Histomorphological analysis during childhood showed progressive hypocellularity with erythroid and megakaryocytic dysplasia and cytogenetic testing demonstrated monosomy 7. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.06.002DOI Listing

Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation.

Curr Opin Genet Dev 2020 Jun 30;62:50-57. Epub 2020 Jun 30.

Department of Genome Sciences, Foege Hall, University of Washington, Seattle, WA 98105, United States; Computational Biology Program, Fred Hutchinson Cancer Research Center, 1100 Eastlake Ave E, Seattle, WA 98109, United States. Electronic address:

There are many possible failure points in the transmission of genetic information that can produce heritable germline mutations. Once a mutation has been passed from parents to offspring for several generations, it can be difficult or impossible to identify its root cause; however, sometimes the nature of the ancestral and derived DNA sequences can provide mechanistic clues about a genetic change that happened hundreds or thousands of generations ago. Here, we review evidence that the sequence context 'spectrum' of germline mutagenesis has been evolving surprisingly rapidly over the history of humans and other species. Read More

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http://dx.doi.org/10.1016/j.gde.2020.05.024DOI Listing

Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.

Lung Cancer 2020 Jun 26;146:310-317. Epub 2020 Jun 26.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010, Australia.

Background: KRAS mutations are found in 20-30 % of non-small cell lung cancers (NSCLC) and were traditionally considered undruggable. KRAS mutation confers sensitivity to KRAS covalent inhibitors, however its prognostic impact remains unclear. This study assesses the frequency, clinical features, prevalence of brain metastases and outcomes in KRAS NSCLC in a real-world setting. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.030DOI Listing

Peripheral cytokines are not influenced by the type of surgical approach for non-small cell lung cancer by four weeks postoperatively.

Lung Cancer 2020 Jun 27;146:303-309. Epub 2020 Jun 27.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, United States. Electronic address:

Objectives: The influence of surgical approach on systemic inflammatory response and the subsequent oncologic impact for non-small cell lung cancer is debated. We aimed to measure the effects of thoracic surgical approach on peripheral cytokine milieu over time.

Methods: Patients undergoing primary lung resection without neoadjuvant therapy (2016-2018) were evaluated. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.022DOI Listing

Characteristics and outcomes of lung cancer in solid organ transplant recipients.

Lung Cancer 2020 Jun 20;146:297-302. Epub 2020 Jun 20.

Columbia University Medical Center, Herbert Irving Pavilion, 161 Fort Washington Avenue, New York, NY 10032, United States; Department of Medicine, Columbia University Medical Center, United States. Electronic address:

Objectives: Lung cancer is the third most common malignancy that develops in patients following solid organ transplantation and is the leading cause of cancer deaths in the general population. The aims of this study are to examine the characteristics of patients who developed lung cancer following solid organ transplantation at our institution and to compare their outcomes to those of lung cancer patients without a history of transplant.

Materials And Methods: We performed a single-institution retrospective study of 44 solid organ transplant recipients who developed lung cancer and compared their characteristics to a cohort of 74 lung cancer patients without a history of transplant. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.018DOI Listing

Performance of preoperative breast MRI based on breast cancer molecular subtype.

Clin Imaging 2020 May 27;67:130-135. Epub 2020 May 27.

Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

Purpose: To assess the performance of preoperative breast MRI biopsy recommendations based on breast cancer molecular subtype.

Methods: All preoperative breast MRIs at a single academic medical center from May 2010 to March 2014 were identified. Reports were reviewed for biopsy recommendations. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.05.017DOI Listing

Chest-CT findings of COVID-19 in patients with pre-existing malignancies; a pictorial review.

Clin Imaging 2020 Jun 9;67:121-129. Epub 2020 Jun 9.

Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.

As of April 17th, 2020, more than 2,190,010 COVID-19 cases with 147,010 deaths have been recorded worldwide. It has been suggested that a high mortality rate occurs in patients with severe disease and is associated with advanced age and underlying comorbidities, such as malignancies. To the best of our knowledge, no study has been conducted to evaluate chest CT features in patients with malignancy and concomitant COVID-19 infection. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.004DOI Listing

Investigation of spectroscopic and proteomic alterations underlying prostate carcinogenesis.

J Proteomics 2020 Jun 30:103888. Epub 2020 Jun 30.

iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. Electronic address:

Prostate cancer (PCa) treatment remains challenging, especially in advanced stages, where the lack of sensitivity and specificity of available biomarkers makes it difficult to establish an accurate prognosis. Therefore, it is imperative to study PCa biology to identify key molecules that can improve PCa management. In this study, eight prostate tumor tissues and paired normal tissues were analyzed using two approaches-Fourier-transform infrared (FT-IR) spectroscopy for spectroscopic profiling of biomolecules and antibody microarray for signaling proteins-with the main goal of identifying metabolic and proteomic changes that enable the distinction between normal and tumor conditions. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103888DOI Listing

Simultaneous multislice diffusion-weighted imaging with short tau inversion recovery fat suppression in bone-metastasizing breast cancer.

Eur J Radiol 2020 Jun 20;130:109142. Epub 2020 Jun 20.

Department of Radiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Purpose: To compare image quality and ADC values of simultaneous multislice diffusion-weighted imaging (mb-DWI) with that of conventional DWI (c-DWI) using short tau inversion recovery fat saturation (STIR) in women with bone-metastasizing breast cancer.

Method: c-DWI and mb-DWI were acquired at 1.5 T in 23 breast cancer patients from skull base to mid thighs. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109142DOI Listing

Elevated Platelet Lymphocyte Ratio is a Poor Prognostic Factor in Advanced Epithelial Ovarian Cancer.

J Gynecol Obstet Hum Reprod 2020 Jun 30:101849. Epub 2020 Jun 30.

Department of Obstetrics and Gynaecology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.

The platelet lymphocyte ratio (PLR) is an important prognostic biomarker in various cancers. The current retrospective study was undertaken to determine the association between PLR and prognosis of advanced epithelial ovarian cancer. We determined the optimal cutoff values of PLR for predicting survival outcomes using the receiver operating characteristic curve analysis. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101849DOI Listing

The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia.

Pharmacol Res 2020 Jun 30:105058. Epub 2020 Jun 30.

Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea. Electronic address:

Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL) cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to be an attractive option to prevent TKI resistance, considering the potential capacity of an HDAC6i to diminish BCR-ABL expression. We first validated the in vivo anti-cancer potential of the compound 7b by significantly reducing the tumor burden of BALB/c mice xenografted with K-562 cells, without notable organ toxicity. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.105058DOI Listing

Pheophorbide a-mediated Sonodynamic, Photodynamic and Sonophotodynamic Therapies Against Prostate Cancer.

Photodiagnosis Photodyn Ther 2020 Jun 30:101909. Epub 2020 Jun 30.

Department of Biophysics, Aydın Adnan Menderes University, Aydın, Turkey. Electronic address:

Anticancer efficiencies and mechanisms of Pheophorbide-a-mediated photodynamic, sonodynamic and sonophotodynamic therapies were investigated in vitro using androgen-sensitive (LNCaP) and androgen insensitive (PC3) prostate cancer cell lines. The cells were incubated in RPMI-1640 media at various concentrations of Pheophorbide-a. The media was treated with 0. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101909DOI Listing

Three Photobiomodulation Protocols in the Prevention/Treatment of Radiotherapy-induced Oral Mucositis.

Photodiagnosis Photodyn Ther 2020 Jun 30:101906. Epub 2020 Jun 30.

Stomatology Department- A.C. Camargo Cancer Center, Sao Paulo, Brazil; Stomatology Department School of Dentistry, Sao Paulo University, Sao Paulo, Brazil. Electronic address:

Purpose: To compare three Photobiomodulation protocols to prevent/treat oral mucositis associated to radiotherapy.

Methods: Seventy-three patients with cancer in oral cavity, oropharynx, and nasopharynx, who underwent RT with dose in facial fields equal or higher than 6000 cGy were randomized into three groups (mean RT dose = 66 cGy ±4.9). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101906DOI Listing

Iron chelation promotes 5-aminolaevulinic acid-based photodynamic therapy against oral tongue squamous cell carcinoma.

Photodiagnosis Photodyn Ther 2020 Jun 30:101907. Epub 2020 Jun 30.

School of Dentistry & Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Background: Oral tongue squamous cell carcinoma (OTSCC) is the most common malignancy of the oral cavity. Photodynamic therapy (PDT) has become a clinically promising approach for OTSCC treatment. 5-Aminolaevulinic acid (5-ALA) is a precursor of protoporphyrin IX (PpIX) and has been applied for PDT of cancer. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101907DOI Listing

A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer.

Nanomedicine 2020 Jun 30:102250. Epub 2020 Jun 30.

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, 310009, China. Electronic address:

Accurate identification of tumor tissues and their margins are still challenging for conventional clinical imaging methods during liver cancer surgery. In this study, dual-band confocal laser endomicroscopy (CLE) combined with image mosaic was used to guide liver cancer surgery. In the experiments with mice bearing orthotropic liver tumor, CLE can accurately detect the tumors and identify their margins with two excitation wavelengths of 488nm and 660nm by clinically available dyes fluorescein sodium (FS) or indocyanine green (ICG). Read More

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http://dx.doi.org/10.1016/j.nano.2020.102250DOI Listing

Early Neutrophil Responses to Chemical Carcinogenesis Shape Long-Term Lung Cancer Susceptibility.

iScience 2020 Jun 17;23(7):101277. Epub 2020 Jun 17.

Tumour Host Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK. Electronic address:

Neoplastic transformation causing cancer is a key problem in tumor biology and can be triggered by exposure to environmental substances. We investigated whether the cellular composition of a tissue contributes to its predisposition to cancer upon a specific carcinogen. Neutrophils are important immune components involved in cancer progression, but their contribution to generation of transformed cells is elusive. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101277DOI Listing

Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats.

Eur J Pharmacol 2020 Jun 30:173310. Epub 2020 Jun 30.

Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Hemorrhagic cystitis is one of the most important complications of cyclophosphamide, a drug widely used in cancer chemotherapy and bone marrow transplantation. 5-HT antagonists are anti-emetic agents and have been shown to have notable anti-inflammatory and antioxidant properties. This study was designed to investigate the possible protective effects of tropisetron against cyclophosphamide-induced hemorrhagic cystitis in rats. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173310DOI Listing

(-)-Kusunokinin inhibits breast cancer in N-nitrosomethylurea-induced mammary tumor rats.

Eur J Pharmacol 2020 Jun 30:173311. Epub 2020 Jun 30.

Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; The Excellent Research Laboratory of Cancer Molecular Biology, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. Electronic address:

Natural and synthetic (-)-kusunokinin inhibited breast cancer, colon cancer and cholangiocarcinoma cells at the G2/M phase and induced apoptosis. However, there is no report on the action and adverse effects of (-)-kusunokinin in animal models. In this study, we investigated the cytotoxic effect of (-)-kusunokinin from Piper nigrum on cancer cells. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173311DOI Listing

Trends of utilization of palliative care and aggressive end-of-life care for patients who died of cancers and those who died of non-cancer diseases in hospitals.

J Pain Symptom Manage 2020 Jun 30. Epub 2020 Jun 30.

Taipei City Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University, Taipei City, Taiwan. Electronic address:

Objectives: This study aimed to evaluate the trends of utilization of palliative care and aggressive end-of-life care for patients who died of cancers and those who died of non-cancer diseases in hospitals.

Methods: The medical records of patients who died in a public hospital due to cancer or other diseases were reviewed. The proportion of those who received palliative care, admitted to intensive care unit (ICU) within 30 days of death, died in ICU, and received cardiopulmonary resuscitation (CPR) within 3 days of death in 2013-2014, 2015-2016, and 2017-2018, respectively, was investigated. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.06.037DOI Listing

miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1.

Mol Cell Probes 2020 Jun 30:101625. Epub 2020 Jun 30.

Department of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin, 300121, PR China. Electronic address:

MicroRNA (miRNA) exerts an important part in colon cancer cell proliferation and apoptosis. Meanwhile, the dysregulation of some miRNAs is detected in colon cancer cells. However, it remains unclear about the underlying mechanism of their effects on tumor pathogenesis. Read More

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http://dx.doi.org/10.1016/j.mcp.2020.101625DOI Listing

Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study.

Int J Biol Macromol 2020 Jun 30. Epub 2020 Jun 30.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China. Electronic address:

Protein tyrosine phosphatase 1B (PTP1B) is a highly validated target for the treatment of type 2 diabetes and obesity. Previous studies have shown that bromophenols from marine red alga Rhodomela confervoides can inhibit PTP1B activity. However, traditional in vitro enzymatic assays may result in false positive activity. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.263DOI Listing

Analyzing Risk Factors for Enterostomy Infection and Neuropsychology of Patients by Computer Information Data Regression under Endoscopic Image Guidance.

Neurosci Lett 2020 Jun 30:135223. Epub 2020 Jun 30.

Gastrointestinal Surgery, Chongqing University Cancer Hospital, No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China. Electronic address:

This study was aimed to investigate the possible risk factors of stoma prolapsing infection and neuropsychological problems after colostomy based on the artificial intelligence DiracNet network. 380 patients who underwent colostomy were selected as the research objects. The clinical data of these patients were analyzed, and postoperative follow-ups were performed. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135223DOI Listing

Impact of compliance to chemoradiation on long-term outcomes in squamous cell carcinoma of the anus. Results of a post-hoc analysis from the randomized phase III ACT II trial.

Ann Oncol 2020 Jun 30. Epub 2020 Jun 30.

School of Medicine, Cardiff University, Cardiff, UK.

Purpose: Concurrent chemoradiation is standard-of-care for patients with squamous cell carcinoma of the anus (SCCA). Poor compliance to chemotherapy, radiotherapy treatment interruptions and unplanned breaks may impact adversely on long-term outcomes.

Methods: The ACT II trial recruited 940 patients with localized SCCA, and assigned patients to mitomycin (week 1) or cisplatin (weeks 1 and 5), with fluorouracil (weeks 1 & 5) and radiotherapy (50·4Gy in 28 fractions over 38 days). Read More

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http://dx.doi.org/10.1016/j.annonc.2020.06.012DOI Listing

Safety assessment of metarrestin in dogs: A clinical candidate targeting a subnuclear structure unique to metastatic cancer cells.

Regul Toxicol Pharmacol 2020 Jun 30:104716. Epub 2020 Jun 30.

National Center for Advancing Translational Sciences, NIH, Rockville, MD, USA. Electronic address:

Pancreatic cancer is a leading cause of cancer-related deaths in the U.S. Ninety percent of patients with stage IV pancreatic cancer die within one year of diagnosis due to complications of metastasis. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104716DOI Listing
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