14,201 results match your criteria Cancer letters[Journal]


Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence.

Cancer Lett 2020 Jul 6. Epub 2020 Jul 6.

Shilpee Dutt Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India. Electronic address:

Glioblastoma (GBM) is the most common primary brain tumor and is highly aggressive with a median survival of 15 months. We have previously shown that residual cells of GBM form multinucleated giant cells (MNGCs) showing a senescent phenotype, but eventually escape from therapy induced senescence (TIS), resulting in GBM recurrence. Here we demonstrate the role of PARP-1 in TIS and its recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.023DOI Listing

Autophagy in the crosstalk between tumor and microenvironment.

Cancer Lett 2020 Jul 4. Epub 2020 Jul 4.

UMR E-4320 TIRO-MATOs CEA/DRF/Institut des sciences du vivant Frédéric Joliot, Université Côte d'Azur, Faculté de Médecine, Nice, France. Electronic address:

Autophagy is the major catabolic process in eukaryotic cells for the degradation and recycling of damaged macromolecules and organelles. It plays a crucial role in cell quality control and nutrient supply under stress conditions. Although autophagy is classically described as a degradative mechanism, it can also be involved in some secretion pathways, leading to the extracellular release of proteins, aggregates, or organelles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.015DOI Listing

Functionalized exosome harboring bioactive molecules for cancer therapy.

Cancer Lett 2020 Jul 2;489:155-162. Epub 2020 Jul 2.

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. Electronic address:

Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circulation in vivo. In this review, we cover recent approaches and advances made in the field of exosome-mediated delivery of bioactive molecules for cancer therapy and factors that affect the clinical use of exosomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.036DOI Listing

Improved efficacy of doxorubicin delivery by a novel dual-ligand-modified liposome in hepatocellular carcinoma.

Cancer Lett 2020 Jun 25;489:163-173. Epub 2020 Jun 25.

School of Bioscience and Technology, Shandong Key Lab of Medical and Health Sciences, Key Lab of Biotechnological Medicine in Universities of Shandong, Weifang Medical University, Weifang, 261053, China. Electronic address:

Liposomes have been widely used as drug carriers in both biomedical research and for clinical applications, allowing the stabilisation of therapeutic compounds and overcoming obstacles to cellular and tissue uptake. However, liposomes still have low targeting efficiency, resulting in insufficient killing of tumour cells and unnecessary damage to normal cells. In this study, glycyrrhetinic acid (GA) and peanut agglutinin (PNA) were used as ligands to prepare dual-ligand-modified doxorubicin-loaded liposomes (DOX-GA/PNA-Lips) to enhance the targeting accuracy and efficacy of drug delivery against malignant liver cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.017DOI Listing

UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.

Cancer Lett 2020 Jun 23. Epub 2020 Jun 23.

Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, China. Electronic address:

Radiation resistance affects survival in non-small-cell lung cancer (NSCLC) patients. Further exploration of mechanisms and targets is urgently needed. Using bioinformatic analyses, we found that UBE2T is associated with survival, tumor size, lymph node metastasis and distant metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.005DOI Listing

Neoantigen-based immunotherapy in pancreatic ductal adenocarcinoma (PDAC).

Cancer Lett 2020 Jun 23;490:12-19. Epub 2020 Jun 23.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. Electronic address:

Neoantigens generated in neoplasms are a type of protein completely absent in healthy tissues. Therefore, anti-tumor immunity targeting neoantigens is highly specific, which provides an optional approach to boost tumor immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies in humans, with few efficient treatments to improve its prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.011DOI Listing

Hypoxia-responsive nanoparticles for tumor-targeted drug delivery.

Cancer Lett 2020 Jun 23;490:31-43. Epub 2020 Jun 23.

School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, 16419, Republic of Korea. Electronic address:

Hypoxia is a negative prognostic indicator of solid tumors. Increasing evidence indicates that the intratumoral hypoxic microenvironment is strongly related to enhanced tumor aggressiveness, decreased therapeutic effect and poor prognosis of chemotherapy, radiotherapy (RT), and photodynamic therapy (PDT). However, due to an unusual gene expression profile and abnormal metabolism, enzymes responsible for reduction reactions or electron donation are highly reactive in hypoxic tumor cells and provide the possibility of exploiting targeted drug delivery systems for cancer therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.032DOI Listing

Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway.

Cancer Lett 2020 Jun 23;490:20-30. Epub 2020 Jun 23.

Department of General Surgery, Peking University First Hospital, Beijing, 100034, China. Electronic address:

Exosomes play important role in tumor microenvironment, and mediate the crosstalk between pancreatic cancer (PC) cells and matrix components including pancreatic stellate cells (PSCs) to regulate pancreatic cancer progression. Here we isolated primary PSCs from PC patients, and demonstrated that PSC-derived exosomes could be internalized by PC cells to promote cell proliferation. Furthermore, we identified that miR-5703 in the exosomes acted as a driver of cell proliferation and its inhibitor suppressed the function of exosomes to promote PC cell proliferation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.009DOI Listing

Acetyltanshinone IIA is more potent than lapatinib in inhibiting cell growth and degrading HER2 protein in drug-resistant HER2-positive breast cancer cells.

Cancer Lett 2020 Jun 23;490:1-11. Epub 2020 Jun 23.

Faculty of Health Sciences, University of Macau, Taipa, Macao SAR, China. Electronic address:

High expression of human epidermal factor receptor 2 (HER2) is directly related to tumor progression, malignancy and drug resistance in HER2-positive breast cancer (HER2-PBC). The major limitation of current anti-HER2 therapies is that they cannot reduce the levels of HER2 protein. Here, we investigated the effect of acetyltanshinone IIA (ATA) in lapatinib-resistant HER2-PBC cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.010DOI Listing

Three dimensional engineered models to study hypoxia biology in breast cancer.

Cancer Lett 2020 Jun 19. Epub 2020 Jun 19.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA; UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Electronic address:

Breast cancer is the second leading cause of mortality among women worldwide. Despite the available therapeutic regimes, variable treatment response is reported among different breast cancer subtypes. Recently, the effects of the tumor microenvironment on tumor progression as well as treatment responses have been widely recognized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.030DOI Listing

Featuring advanced translational strategies: Principles, techniques, devices and applications.

Authors:
Zhe Liu

Cancer Lett 2020 Jun 20;489:133-134. Epub 2020 Jun 20.

Academy of Medical Engineering and Translational Medicine, Tianjin University, No. 92 Weijin Rd, Nankai District, Tianjin, 300072, China. Electronic address:

The ever-emerging developments and innovations on the advanced translational strategies for diagnosing and treating fatal human diseases are substantially re-shaping our future and improving the human health quality. This special issue published several mini-review manuscripts covering fundamental principles, techniques, devices and applications in the related fields. Several investigators including basic research scientists and medical doctors have described recent breakthroughs in the fields of cancer therapy, biomedical engineering, material sciences and their translational medicine from-bench-to-bed into clinical uses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305764PMC

Corrigendum to "NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma" [Canc. Lett. 476 (2020) 48-56].

Cancer Lett 2020 Jun 17. Epub 2020 Jun 17.

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.007DOI Listing

Extracellular vesicle long non-coding RNAs and circular RNAs: Biology, functions and applications in cancer.

Cancer Lett 2020 Jun 16;489:111-120. Epub 2020 Jun 16.

Fudan University Shanghai Cancer Center, Shanghai Key Laboratory of Medical Epigenetics, Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Extracellular vesicles (EVs) have been recognized as vital mediators of intercellular communication that allow horizontal information exchange among tumor cells as well as reciprocal cross-talk between tumor and stromal cells. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are selectively packaged into EVs then transferred to proximal and distal recipient cells, inducing profound phenotypic changes. Recently, there has been substantial progress in understanding the essential roles of EV-associated lncRNAs and circRNAs in cancer initiation and progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.006DOI Listing

Hypoxia in bone metastasis and osteolysis.

Cancer Lett 2020 Jun 16;489:144-154. Epub 2020 Jun 16.

Graduate Program in Cancer Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Center for Bone Biology, Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Hypoxia is a common feature in tumors, driving pathways that promote epithelial-to-mesenchymal transition, invasion, and metastasis. Clinically, high levels of hypoxia-inducible factor (HIF) expression and stabilization at the primary site in many cancer types is associated with poor patient outcomes. Experimental evidence suggests that HIF signaling in the primary tumor promotes their dissemination to the bone, as well as the release of factors such as LOX that act distantly on the bone to stimulate osteolysis and form a pre-metastatic niche. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.004DOI Listing

Heterogeneity and vascular permeability of breast cancer brain metastases.

Cancer Lett 2020 Jun 16;489:174-181. Epub 2020 Jun 16.

Department of Neurological Surgery, The Feinberg School of Medicine, 303 E. Superior Street, Northwestern University, Chicago, IL, 60611, USA. Electronic address:

Improvements in the diagnosis and treatment of systemic breast cancer have led to a prolongation in patient survival. Unfortunately, these advances are also associated with an increased incidence of brain metastases (BM), with the result that many patients succumb due to BM treatment failure. Intracranial delivery of many chemotherapeutic agents and other therapeutics is hindered by the presence of an impermeable blood-brain barrier (BBB) designed to protect the brain from harmful substances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.012DOI Listing

Polycystin-1 induces activation of the PI3K/AKT/mTOR pathway and promotes angiogenesis in renal cell carcinoma.

Cancer Lett 2020 Jun 16;489:135-143. Epub 2020 Jun 16.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens, 11527, Greece. Electronic address:

In the present study we investigated the expression and the functional role of mechanosensitive polycystins in renal cell carcinoma (RCC). In 115 RCC patients we evaluated the protein expression of polycystin-1 (PC1), polycystin-2 (PC2), VEGF and protein components of the PI3K/Akt/mTOR pathway, which have been implicated both in RCC and polycystic kidney disease. PC1 and PC2 demonstrated reduced expression throughout the RCC tissue compared to the adjacent normal tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.016DOI Listing

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors.

Cancer Lett 2020 Jun 15;489:100-110. Epub 2020 Jun 15.

Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan. Electronic address:

REV7 is a multitasking protein involved in replication past DNA lesions, cell cycle regulation, and gene expression. REV7 is highly expressed in the adult testis and plays an essential role in primordial germ cell maintenance in mice. In this study, we analyzed whether REV7 can be a molecular target for the treatment of testicular germ cell tumors (TGCTs), in which acquired chemoresistance is a major cause of treatment failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.001DOI Listing
June 2020
5.621 Impact Factor

Direct targeting of HSP90 with daurisoline destabilizes β-catenin to suppress lung cancer tumorigenesis.

Cancer Lett 2020 Jun 13;489:66-78. Epub 2020 Jun 13.

MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. Electronic address:

Lung cancer is the most frequent cancer worldwide with a poor prognosis. Identification of novel cancer targets and useful therapeutic strategies without toxicity are urgently needed. In this study, we screened natural products for anticancer bioactivity in a library consisting of 429 small molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.024DOI Listing
June 2020
5.621 Impact Factor

HIF1α inhibitor 2-methoxyestradiol decreases NRN1 expression and represses in vivo and in vitro growth of patient-derived testicular germ cell tumor spheroids.

Cancer Lett 2020 Jun 13;489:79-86. Epub 2020 Jun 13.

Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, 173-0015, Japan. Electronic address:

Testicular germ cell tumor (GCT) is the most common type of malignancy in young males. Patients with nonseminomatous GCT still have poor prognosis. To identify new therapeutic targets, we generated patient-derived cells (PDCs) and their xenograft (PDCX) models from 3 distinct GCT patients' specimens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.040DOI Listing

ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.

Cancer Lett 2020 Jun 10;489:121-132. Epub 2020 Jun 10.

Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Division for Health Service Promotion, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address:

The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.002DOI Listing
June 2020
5.621 Impact Factor

Landscape characterization of chimeric RNAs in colorectal cancer.

Cancer Lett 2020 Jun 10;489:56-65. Epub 2020 Jun 10.

Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA. Electronic address:

Gene fusions and their fusion products have been recognized as ideal biomarkers and drug targets for cancer. However, few recurrent gene fusions were found in colorectal cancer (CRC), despite comprehensive studies. We believe that chimeric RNAs, in the absence of chromosomal rearrangement, may represent a new repertoire of biomarkers and/or therapeutic targets in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.037DOI Listing

Clinical uses of 5-aminolaevulinic acid in photodynamic treatment and photodetection of cancer: A review.

Authors:
Adriana Casas

Cancer Lett 2020 Jun 10. Epub 2020 Jun 10.

Centro de Investigaciones Sobre Porfirinas y Porfirias (CIPYP), CONICET-Htal de Clínicas José de San Martín, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. Electronic address:

ALA-mediated Photodynamic Therapy (ALA-PDT) is one of the most promising fields in Photodynamic therapy (PDT) research for cancer treatment. 5-aminolaevulinic acid (ALA) is the prodrug of the photosensitiser Protoporphyrin IX (PpIX). After ALA administration, cells generate PpIX through the haem biosynthetic pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.06.008DOI Listing

Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway.

Cancer Lett 2020 Jun 9;489:87-99. Epub 2020 Jun 9.

Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:

Exosomes are key mediators of intercellular communication and play a role in the pathogenesis and progression of cancer. Exosomes in circulating body fluids serve as molecular markers for cancer diagnosis. This study aimed to investigate the role of exosomal microRNA (miR)-1910-3p in breast cancer and determine its clinical diagnostic value. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.038DOI Listing

Hypoxia-driven epigenetic regulation in cancer progression: A focus on histone methylation and its modifying enzymes.

Cancer Lett 2020 Jun 6;489:41-49. Epub 2020 Jun 6.

Department of Pharmacology, Cancer Research Institute, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

The mechanism underlying hypoxia-driven chromatin remodeling is a long-lasting question. For the last two decades, this question has been resolved in part. It is now widely agreed that hypoxia dynamically changes the methylation status of histones to control gene expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.025DOI Listing

STAT3: A key signaling molecule for converting cold to hot tumors.

Cancer Lett 2020 Jun 6;489:29-40. Epub 2020 Jun 6.

Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Tumors can be classified as cold or hot according to the degree of immune cell infiltration into tumor tissues; cold tumors are insensitive to either chemotherapy or immunotherapy and are associated with poor prognosis. Recent studies have shown that STAT3 signaling molecules hinder the conversion of cold to hot tumors by regulating immunosuppressive molecule secretion and immunosuppressive cell functions. This review aims to present the most recent studies on how STAT3 regulates cold tumor formation and discuss its research status in cancer therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.035DOI Listing
June 2020
5.621 Impact Factor

Resolving the HIF paradox in pancreatic cancer.

Cancer Lett 2020 Jun 5;489:50-55. Epub 2020 Jun 5.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related deaths and has a 5-year survival rate of less than 10%, far below the ~70% national average for all cancers. This poor prognosis is driven by an extreme resistance to nearly all known cancer treatments, which has long been attributed to hypoxia driven interactions between tumor cells and the supporting stromal microenvironment. The cellular response to hypoxia is driven by the transcription factors known as the hypoxia inducible factors (HIFs), which have been hypothesized to play a role in the pathobiology of PDAC as well as a potential therapeutic target based on years of cell culture data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.033DOI Listing

Beyond glycolysis: Hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma.

Cancer Lett 2020 Jun 5;489:19-28. Epub 2020 Jun 5.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. Electronic address:

The relationship between kidney cancer, specifically clear cell renal cell carcinoma (ccRCC), and the hypoxia signaling program has been extensively characterized. Its underlying role as the primary driver of the disease has led to the development of the most effective targeted therapies to date. Cellular responses to hypoxia or mutations affecting the von Hippel-Lindau (VHL) tumor suppressor gene stabilize the hypoxia inducible factor (HIF) transcription factors which then orchestrate elaborate downstream signaling events resulting in adaptations to key biological processes, such as reprogramming metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.034DOI Listing

Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis.

Cancer Lett 2020 Jun 3;489:9-18. Epub 2020 Jun 3.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, FC7.2000, Unit Number: 442, Houston, TX, 77030, USA. Electronic address:

Stereotactic Radiosurgery has become the main treatment for patients with limited number of brain metastases (BM). Recently, with the increasing use of this modality, there is a growth in recurrence cases. Recurrence after radiation therapy can be divided in changes favoring either tumor recurrence or radiation necrosis (RN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.014DOI Listing

The two faces of giant cell tumor of bone.

Cancer Lett 2020 Jun 2;489:1-8. Epub 2020 Jun 2.

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", National Research Council of Italy, Naples, Italy. Electronic address:

Giant cell tumor (GCT) is a bone-destructive benign neoplasm characterized by distinctive multinucleated osteoclast-like giant cells with osteolytic properties distributed among neoplastic stromal cells. GCT is locally aggressive with progressive invasion of adjacent tissues and occasionally displays malignant characteristics including lung metastasis. GCT is characterized genetically by highly recurrent somatic mutations at the G34 position of the H3F3A gene, encoding the histone variant H3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.031DOI Listing
June 2020
5.621 Impact Factor

Corrigendum to "Infiltrating neutrophils promote renal cell carcinoma (RCC) proliferation via modulating androgen receptor (AR) → c-Myc signals" [Cancer Lett. 2015 Nov 1 368(1) 71-78].

Cancer Lett 2020 Aug 30;485:66. Epub 2020 May 30.

George Whipple Lab for Cancer Research, Departments of Urology and Pathology, University of Rochester Medical Center, Rochester, NY, 14642, USA; Sex Hormone Research Center, China Medical University and Hospital, Taichung, 404, Taiwan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.017DOI Listing
August 2020
5.621 Impact Factor

Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer.

Cancer Lett 2020 Sep 30;488:40-49. Epub 2020 May 30.

Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address:

The dependency of prostate cancer (PCa) growth on androgen receptor (AR) signaling has been harnessed to develop first-line therapies for high-risk localized and metastatic PCa treatment. However, the occurrence of aberrant expression, mutated or splice variants of AR confers resistance to androgen ablation therapy (ADT), radiotherapy or chemotherapy in AR-positive PCa. Therapeutic strategies that effectively inhibit the expression and/or transcriptional activity of full-length AR, mutated AR and AR splice variants have remained elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.027DOI Listing
September 2020

Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy.

Cancer Lett 2020 Sep 30;488:9-17. Epub 2020 May 30.

Rutgers New Jersey Medical School, Department of Medicine, Newark, NJ, 07103, USA. Electronic address:

Breast cancer (BC) remains a clinical challenge despite improved treatments and public awareness to ensure early diagnosis. A major issue is the ability of BC cells (BCCs) to survive as dormant cancer cells in the bone marrow (BM), resulting in the cancer surviving for decades with the potential to resurge as metastatic cancer. The experimental evidence indicates similarity between dormant BCCs and other stem cells, resulting in the preponderance of data to show dormant BCCs being cancer stem cells (CSCs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.026DOI Listing
September 2020

Corrigendum to "SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo" [Cancer Lett. 351 (2014) 143-50].

Cancer Lett 2020 Aug 29;486:71-72. Epub 2020 May 29.

Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.010DOI Listing

The choice of anti-tumor strategies based on micromolecules or drug loading function of biomaterials.

Cancer Lett 2020 Sep 29;487:45-52. Epub 2020 May 29.

Department of Urology, The Second Hospital of TianJin Medical University, TianJin Institute of Urology, Tianjin, 300211, China. Electronic address:

With advances in modern medicine, diverse tumor therapies have been developed. However, because of a lack of effective methods, the delivery of drugs or micromolecules in the human body has many limitations. Biomaterials are natural or synthetic functional materials that are prone to contact or interact with living systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.019DOI Listing
September 2020

Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells.

Cancer Lett 2020 Sep 28;488:50-62. Epub 2020 May 28.

Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic address:

Colon cancer is a therapy-resistant cancer with a low 5-year survival frequency. The drug 5-fluorouracil (5-FU) has been used as a first-line therapy in metastatic colon cancer in combination with leucovorin or oxaliplatin with a >40% resistance rate. High CysLTR expression in tumors is associated with poor survival of colon cancer patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.023DOI Listing
September 2020

Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis.

Cancer Lett 2020 Sep 28;488:27-39. Epub 2020 May 28.

Department of Oncology and Metabolism, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK; Bone and Cancer Group, Edinburgh Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XR, UK. Electronic address:

Tumour necrosis factor receptor-associated factor 6 (TRAF6) has been implicated in breast cancer and osteoclastic bone destruction. Here, we report that 6877002, a verified small-molecule inhibitor of TRAF6, reduced metastasis, osteolysis and osteoclastogenesis in models of osteotropic human and mouse breast cancer. First, we observed that TRAF6 is highly expressed in osteotropic breast cancer cells and its level of expression was higher in patients with bone metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.021DOI Listing
September 2020
5.621 Impact Factor

MiR-182-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-C.

Cancer Lett 2020 Sep 27;488:18-26. Epub 2020 May 27.

Central Laboratory of the First Affiliated Hospital & Department of Rheumatology of the First Affiliated Hospital, Weifang Medical University, Weifang, 261000, China. Electronic address:

MicroRNAs (miRNAs) are gene modulators essential for biological processes. However, the precise functions of miRNAs in growth and development of colon cancer are still elusive. To clarify their role, here we analyzed a miRNA microarray of colon cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.04.021DOI Listing
September 2020
5.621 Impact Factor

Blocking histone methyltransferase SETDB1 inhibits tumorigenesis and enhances cetuximab sensitivity in colorectal cancer.

Cancer Lett 2020 Sep 27;487:63-73. Epub 2020 May 27.

GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to histone H3 at lysine 9, and upregulation of SETDB1 is associated with poor prognosis in cancer patients. Here, we describe how overexpression of SETDB1 contributes to colorectal cancer (CRC) tumorigenesis and drug resistance. We show that SETDB1 is upregulated in CRC, and its level correlates with poor clinical outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.029DOI Listing
September 2020
5.621 Impact Factor

Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice.

Cancer Lett 2020 Sep 27;487:53-62. Epub 2020 May 27.

Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.

Tumor-stromal interaction is implicated in tumor progression. Although CCR1 expression in myeloid cells could be associated with pro-tumor activity, it remains elusive whether disruption of CCR1-mediated myeloid cell accumulation can suppress tumor progression. Here, we investigated the role of CCR1 depletion in myeloid cells in two syngeneic colorectal cancer mouse models: MC38, a transplanted tumor model and CMT93, a liver metastasis model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.028DOI Listing
September 2020

Exosomes in hypoxia-induced remodeling of the tumor microenvironment.

Cancer Lett 2020 Sep 27;488:1-8. Epub 2020 May 27.

Department of Cancer Biology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA; Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:

Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biological "snapshot" of parent cells, and their cargos (protein, nucleotides, lipids, and metabolites) are loaded uniquely under different pathophysiological conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.018DOI Listing
September 2020

Hypoxia: Turning vessels into vassals of cancer immunotolerance.

Cancer Lett 2020 Sep 26;487:74-84. Epub 2020 May 26.

UCD School of Medicine and UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, D04 C7X2, Ireland. Electronic address:

Hypoxia is a universal feature of solid cancers caused by a mismatch between cellular oxygen supply and consumption. To meet the increased demand for oxygen, hypoxic cancer cells (CCs) induce a multifaceted process known as angiogenesis, wherein new vessels are formed by the sprouting of pre-existing ones. In addition to providing oxygen for growth and an exit route for dissemination, angiogenic vessels and factors are co-opted by CCs to enable the generation of an immunotolerant, hypoxic tumor microenvironment, leading to therapeutic failure and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.015DOI Listing
September 2020

The hypoxic tumour microenvironment: A safe haven for immunosuppressive cells and a therapeutic barrier to overcome.

Cancer Lett 2020 Sep 26;487:34-44. Epub 2020 May 26.

Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, United Kingdom. Electronic address:

Dating back to the seminal work of Paul Ehrlich, the idea of harnessing our immune system to eliminate cancerous cells is now over a century old. In the presence of a functional immune system that so efficiently guards the host against developing neoplasms, tumour cells must evolve sophisticated strategies to escape immune destruction in order to give rise to clinically detectable cancers. A new way of treating cancer would thus be to target the immune system itself rather than the tumour, and extensive studies in randomised trials have cemented the possibility of using immunotherapy for treating advanced-stage cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.011DOI Listing
September 2020

Extracellular vesicle cross-talk in the liposarcoma microenvironment.

Cancer Lett 2020 Sep 26;487:27-33. Epub 2020 May 26.

The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Liposarcoma (LPS) is the most prevalent soft tissue sarcoma; among the four different LPS subtypes, dedifferentiated liposarcoma (DDLPS) is especially worrisome given its propensity for local and distant recurrence, with an overall survival rate of only 10% at 10 years. Our understanding of the molecular drivers of this disease is rudimentary at best; knowledge about how DDLPS interacts with cells in the tumor microenvironment (TME) is also lacking. Extracellular vesicle (EVs) have been studied in a number of different systems concerning their ability to influence the TME transferring bioactive molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.04.026DOI Listing
September 2020

Hypoxia-induced epithelial to mesenchymal transition in cancer.

Cancer Lett 2020 Sep 26;487:10-20. Epub 2020 May 26.

Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

A common feature of many solid tumors is low oxygen conditions due to inadequate blood supply. Hypoxia induces hypoxia inducible factor (HIF) stabilization and downstream signaling. This signaling has pleiotropic roles in cancers, including the promotion of cellular proliferation, changes in metabolism, and induction of angiogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336507PMC
September 2020

Lung cancer survival in never-smokers and exposure to residential radon: Results of the LCRINS study.

Cancer Lett 2020 Sep 24;487:21-26. Epub 2020 May 24.

Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología and Salud Pública - CIBERESP), Spain.

We aimed to evaluate lung cancer survival in never-smokers, both overall and specifically by sex, exposure to residential-radon, age, histological type, and diagnostic stage. We included lung cancer cases diagnosed in a multicentre, hospital-based, case-control-study of never-smoker patients, diagnosed from January-2011 to March-2015 (Lung Cancer Research In Never Smokers study). 369 never-smokers (79% women; median age 71 years; 80% adenocarcinoma; 66% stage IV) were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.022DOI Listing
September 2020

Adenovirus-mediated specific tumor tagging facilitates CAR-T therapy against antigen-mismatched solid tumors.

Cancer Lett 2020 Sep 23;487:1-9. Epub 2020 May 23.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, PR China. Electronic address:

Chimeric antigen receptor T (CAR-T) therapy faces at least two major obstacles in solid tumors, including to find specific antigen among the heterogeneous tumor mass and to overcome the inhibitory microenvironment. Developing novel strategies to overcome these difficulties has been the burning issue in immunotherapy. Here we came up with the concept of tagging cancer cells by tumor-targeting adenoviruses (Ad). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.013DOI Listing
September 2020

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma.

Cancer Lett 2020 Aug 21;486:8-17. Epub 2020 May 21.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France. Electronic address:

HCC is a highly lethal malignancy with Sorafenib as the only molecularly targeted drug. The multifunctional stress-associated protein, NUPR1, plays an essential role in controlling cell growth, migration, invasion and Sorafenib resistance in HCC. We report here that NUPR1 expression is absent in healthy liver and it is progressively upregulated in HCC premalignant lesions such as hepatitis and cirrhosis with a maximum expression in HCC samples, highlighting that NUPR1 is a potential drug target for HCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.04.024DOI Listing

Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges.

Cancer Lett 2020 Aug 22;486:29-37. Epub 2020 May 22.

Discipline of Pathology, Cancer Progression and Treatment Research Group, Lambe Institute for Translational Research, School of Medicine, National University of Ireland-Galway, Galway, Ireland. Electronic address:

Estrogen receptor 1 (ESR1, which encodes estrogen receptor-alpha) is a key driver gene for the initiation and progression of hormone receptor-positive breast cancer. Estrogen receptor-alpha (ER) is expressed in up to 70% of cases, and patients are routinely treated with endocrine therapies. However, the development of resistance over time is common and occurs in one-third of ER-positive breast tumors, leading to disease progression and death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.020DOI Listing

The novel dual BET/HDAC inhibitor TW09 mediates cell death by mitochondrial apoptosis in rhabdomyosarcoma cells.

Cancer Lett 2020 Aug 20;486:46-57. Epub 2020 May 20.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstrasse 3a, 60528, Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Targeting the epigenome of cancer cells with the combination of Bromodomain and Extra Terminal (BET) protein inhibitors and histone deacetylase (HDAC) inhibitors has shown synergistic antitumor effects in several cancer types. In this study, we investigate the antitumor potential of the novel dual BET/HDAC inhibitor TW09 in rhabdomyosarcoma (RMS) cells. TW09 reduces cell viability, suppresses long-term clonogenic survival and induces cell death in RMS cells in a dose-dependent manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2020.05.008DOI Listing