Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.
- Wei Wang,
- Hanna M Ollila,
- Alice S Whittemore,
- Shadmehr Demehri,
- Nilah M Ioannidis,
- Eric Jorgenson,
- Emmanuel Mignot,
- Maryam M Asgari
Cancer Immunol Immunother 2018 May 12. Epub 2018 May 12.
Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, Suite 270, 02114, Boston, MA, USA.
Background: The immune system has been implicated in the pathophysiology of cutaneous squamous cell carcinoma (cSCC) as evidenced by the substantially increased risk of cSCC in immunosuppressed individuals. Associations between cSCC risk and single nucleotide polymorphisms (SNPs) in the HLA region have been identified by genome-wide association studies (GWAS). The translation of the associated HLA SNPs to structural amino acids changes in HLA molecules has not been previously elucidated. Read More