3,779,149 results match your criteria Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Preventive Oncology[Journal]


Axillary web syndrome: What the radiologist needs to know.

Breast J 2018 Dec 17. Epub 2018 Dec 17.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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December 2018

Expression Profiles of microRNAs in Drug-Resistant Non-Small Cell Lung Cancer Cell Lines Using microRNA Sequencing.

Cell Physiol Biochem 2018 Dec 17;51(6):2509-2522. Epub 2018 Dec 17.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,

Background/aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines.

Methods: The expression profiles of miRNAs in drug-resistant NSCLC cell lines were examined using miRNA sequencing, and the common dysregulated miRNAs in these cell lines were identified and analyzed by bioinformatics methods. Read More

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December 2018

Hybridization of graphene oxide into nanogels to acquire higher photothemal effects for therapeutic delivery.

Nanotechnology 2018 Dec 17. Epub 2018 Dec 17.

Materials Science&Engineering, East China University of Science and Technology, No.130, Meilong Rd, Xuhui District, Shanghai, Shanghai, 200237, CHINA.

Although the special architecture of two-dimensional (2D) nanomaterials endows them with unique properties, their poor colloidal stability remains a main bottleneck to fully exploit their applications in the biomedical field. Herein, this study aims to develop a simple and effective approach to in situ incorporate 2D graphene oxide (GO) nanopletlets into thermosensitive matrix to acquire hybrid nanogels with good stability and photothermal effect. In order to improve its stability, GO firstly underwent silanization to its surface with double bonds, followed by intercalation with N-isopropylacrylamide (NIPAM) in the presence of disulfide-containing crosslinker via an emulsion method. Read More

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December 2018

Testing the gene expression classification of the EMT spectrum.

Phys Biol 2018 Dec 17. Epub 2018 Dec 17.

Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX 77251-1892, USA, Houston, Texas, UNITED STATES.

The epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis and drug resistance - two persistent clinical challenges. Epithelial cells can undergo a partial or full EMT, attaining either a hybrid epithelial/mesenchymal (E/M) or mesenchymal phenotype, respectively. Recent studies have emphasized that hybrid E/M cells may be more aggressive than their mesenchymal counterparts. Read More

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December 2018

Apatinib inhibits tumor growth and angiogenesis in PNET models.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

Z Wang, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. Read More

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December 2018

Non-canonical AR activity facilitates endocrine resistance in breast cancer.

Endocr Relat Cancer 2019 Feb;26(2):251-264

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

The role of androgen receptor (AR) in endocrine-resistant breast cancer is controversial and clinical trials targeting AR with an AR antagonist (e.g., enzalutamide) have been initiated. Read More

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February 2019

Safety and efficacy of two starting doses of vandetanib in advanced medullary thyroid cancer.

Endocr Relat Cancer 2019 Feb;26(2):241-250

Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Vandetanib is an oral tyrosine kinase inhibitor approved for treatment of advanced symptomatic or progressive medullary thyroid cancer (MTC). The current study (Nbib1496313) evaluated the benefit-risk of two starting doses of vandetanib in patients with symptomatic or progressive MTC. Patients were randomized 1:1 to receive vandetanib 150 or 300 mg daily and followed for a maximum of 14 months (Part A), with the option to then enter an open-label phase (Part B) investigating vandetanib 100, 150, 200 and 300 mg daily doses. Read More

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February 2019

Improved ELISA for tumor marker detection using electro-readout-mode based on label triggered degradation of methylene blue.

Biosens Bioelectron 2018 Dec 7;126:800-805. Epub 2018 Dec 7.

Department of Chemistry, Capital Normal University, Beijing 100048, China. Electronic address:

Enzyme-linked immunosorbent assay (ELISA), a gold-standard method for protein detection, has been widely utilized in disease diagnosis. Nevertheless, the method is constrained by its dependence on a colorimetric readout that, due to its relatively low sensitivity, prevents its use in tumor marker detection. Here we demonstrate an ELISA that incorporates an electro-readout mode in place of a colorimetric readout to achieve ultrasensitive and convenient tumor marker detection. Read More

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December 2018
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MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer.

Biomed Pharmacother 2018 Dec 14;110:850-856. Epub 2018 Dec 14.

Department of Gynaecology and Obstetrics, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China. Electronic address:

MicroRNA-542-3p (miR-542-3p) has been implicated in several cancers; however, its precise role in ovarian cancer is unclear. In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. Read More

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December 2018

Patterns and trends of HPV-related cancers other than cervix in South Africa from 1994-2013.

Cancer Epidemiol 2018 Dec 14;58:121-129. Epub 2018 Dec 14.

Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, 22 Esselen Street, Hillbrow, Johannesburg, 2001, South Africa.

Background: HPV infection causes several cancers which include cervical, vaginal, vulval, penile and oropharyngeal cancer (OPC). Understanding the burden of HPV-related cancers is important for guiding cancer prevention and treatment interventions.

Methods: To inform policy, we analysed trends of age-standardised incidence (ASIR) and mortality (ASMR) rates for HPV-related head and neck (HNC) and anogenital cancers (AGC) in South Africa between 1994 and 2013. Read More

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December 2018

Identification of novel PI3Kδ inhibitors by docking, ADMET prediction and molecular dynamics simulations.

Comput Biol Chem 2018 Dec 7;78:190-204. Epub 2018 Dec 7.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address:

Background: Phosphoinositide-3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ is confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Virtual screening techniques have been used to discover new molecules for developing novel PI3Kδ inhibitors with little side effects.

Method: Computer aided drug design method were used to rapidly screen optimal PI3Kδ inhibitors from the Asinex database. Read More

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December 2018

Fine particle-bound polycyclic aromatic hydrocarbons (PAHs) at an urban site of Wuhan, central China: Characteristics, potential sources and cancer risks apportionment.

Environ Pollut 2018 Dec 3;246:319-327. Epub 2018 Dec 3.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, China; Department of Environmental Science and Engineering, School of Environmental Studies, China University of Geosciences, Wuhan, 430074, China.

Levels, compositions, sources, and cancer risks of fine particle (PM)-bound PAHs were investigated at an urban site of Wuhan, Central China. Totally 115 PM samples collected during four seasons from 2014 to 2015 were analyzed for 16 USEPA priority PAHs. The annual average of PM and total PAHs were 106 ± 41. Read More

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December 2018

Association of quality of life with disease characteristics and treatment outcomes in patients with advanced gastric cancer: Exploratory analysis of RAINBOW and REGARD phase III trials.

Eur J Cancer 2018 Dec 14;107:115-123. Epub 2018 Dec 14.

Institute of Clinical Cancer Research (IKF), University Cancer Center, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. Electronic address:

Background: Inadequate understanding of interpretation of quality of life (QoL) instruments leads to unsatisfactory data reporting and clinical decision-making, including in gastric cancer care.

Materials And Methods: Pooled QoL data from two phase III studies of ramucirumab with or without paclitaxel in previously treated patients with gastric or gastroesophageal junction cancer were used to explore associations with clinical attributes, including tumour response, disease measurability and performance status (PS). The European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire (QLQ)-C30 was used in both studies. Read More

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December 2018

Biosynthesized of reduced graphene oxide nanosheets and its loading with paclitaxel for their anti cancer effect for treatment of lung cancer.

J Photochem Photobiol B 2018 Nov 22;191:13-17. Epub 2018 Nov 22.

Department of pharmacy, Fujian Provincial Hospital& Fujian Medical University, People's Republic of China; Molecular Biology Laboratory of Chinese Traditional Medicine, Fujian Provincial Hospital, People's Republic of China. Electronic address:

Multifunctional nanocarriers are in immediate need to develop anticancer activity for the treatment of cancers. In the present research, the graphene oxide was reduced via an efficient method which reduced to RGO by using Euphorbia milii leaves extract. Thus obtained RGO nanocomposites were subsequently characterized by means UV-Vis absorption technique. Read More

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November 2018

Biosynthesis of sorafenib coated graphene nanosheets for the treatment of gastric cancer in patients in nursing care.

J Photochem Photobiol B 2018 Nov 20;191:1-5. Epub 2018 Nov 20.

The Third Department of Tumor Surgery, Tangshan Gongren Hospital, People's Republic of China. Electronic address:

Sorafenib (SRF) is a well-known tyrosine kinase inhibiting anticancer drug which iseffectual against multiple carcinomas especially gastric cancers by targeting the Ras/Raf/Mek/Erk cascade pathway and blocking the tumor cell proliferation. In the present work, we have reduced graphene oxide (GO) in presence of sorafenib using ascorbic as green reducing agent for the treatment of gastric cancers. Sorafenib reduced graphene oxide (SRGO) were obtained with a transparent and smoothmorphology. Read More

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November 2018

Breaking habits with mindful snacking? An email-based intervention targeting unwanted snacking habits in an Australian sample.

Eat Behav 2018 Nov 30;32:37-43. Epub 2018 Nov 30.

CSIRO, Health and Biosecurity, Kintore Ave, Adelaide 5001, Australia.

Objective: To investigate the potential for an email-based, mindful eating exercise to improve unwanted snacking habits.

Method: Australian participants (N = 78, 86% female) with unwanted snacking habits engaged in a mindful eating email-based intervention, over a practice period of two weeks. All measures were completed using an online survey. Read More

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November 2018

Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Houston VA Health Services Research and Development Service Center of Excellence (Houston, TX), Section of Health Services Research, Michael E. DeBakey VA Medical Center (Houston, TX) and Baylor College of Medicine, Houston, TX. Electronic address:

Background & Aims: Early detection of hepatocellular carcinoma (HCC) through surveillance reduces mortality associated with this cancer. Guidelines recommend HCC surveillance every 6 months for patients with cirrhosis, via ultrasonography, with or without measurement of serum level of alpha fetoprotein (AFP).

Methods: We previously developed and internally validated an HCC early detection screening (HES) algorithm that included patient's current level of AFP, rate of AFP change, age, level of alanine aminotransferase, and platelet count in a department of Veterans affairs (VA) cohort with active hepatitis C virus-related cirrhosis. Read More

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December 2018

Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-associated Genes in Patients With Multiple Colorectal Polyps.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Ambry Genetics, Aliso Viejo, CA.

Background And Aims: Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests-especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. Read More

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December 2018

Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A.

Ecotoxicol Environ Saf 2018 Dec 14;170:495-501. Epub 2018 Dec 14.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Halogenated bisphenol A analogues (X-BPA) have been widely used in industrial production, such as flame retardant. Although BPA exposure was found to result in cytotoxicity, toxicity of X-BPA and molecular mechanism remain under-explored. In this study, we employed human breast cancer cell as a model to investigate the concentration-dependent toxicity and underlying mechanisms of tetrabromo bisphenol A (TBBPA) and tetrachloro bisphenol A (TCBPA). Read More

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December 2018

DOX Loaded Aggregation-induced Emission (AIE) Active Polymeric Nanoparticles as Fluorescence Resonance Energy Transfer (FRET) Traceable Drug Delivery System for Self-indicating Cancer Therapy.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, PR China. Electronic address:

In this study, an AIE-active polymer (FTP) was successfully prepared and employed to load anti-cancer drug doxorubicin (DOX) for self-indicating cancer therapy via dual FRET process. Our results demonstrated that the FTP polymer could self-assemble into nanoparticles (NPs) in aqueous solutions to give strong fluorescence emission via intramolecular FRET process. The DOX loaded FTP NPs (drug loading content: 21. Read More

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December 2018

Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India. Electronic address:

Microneedle-devices provide a promising alternative to syringe-injection-based administration of chemotherapeutics. Dissolvable polymeric microneedles provide possibility of carrying greater payload and dual drugs. Here, we report development of polyvinyl pyrrolidone and polyvinyl alcohol composite dissolvable polymeric microneedle system for co-delivery of doxorubicin HCl and docetaxel. Read More

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December 2018
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RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, China.

Nanocrystals has been constructed for insoluble drugs as a novel type of nanoscale drug delivery systems with high drug loading. How to prepare nanocrystals with good stability and tumor targeting capability is still challenging. This study was to modify paclitaxel nanocrystals with polyethylene glycol (PEG) for stabilization and RGD peptide for tumor targeting. Read More

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December 2018

The Insurance Approval Process for Proton Radiation Therapy: A Significant Barrier to Patient Care.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology; Proton Therapy Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Purpose: Proton therapy is increasingly prescribed for cancer treatment given its potential for improvements in clinical outcomes and toxicity reduction; however, insurance coverage continues to be a barrier to patient access. This study examined insurance approval and appeal outcomes at a large volume proton therapy center to clarify the process and identify areas for improvement.

Methods: In 2013-2016, 1753 patients with thoracic or head and neck (HN) cancer were considered for proton therapy; 903 (553 thoracic, 350 HN) entered the insurance process. Read More

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December 2018

Mechanistic modelling of Radium-223 treatment of bone metastases.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.

Introduction: Despite the effectiveness of RaCl for treating patients with symptomatic bone metastatic disease, its mechanisms of action are still unclear. Even established dosimetric approaches differ considerably in their conclusions. In silico tumour models bring a new perspective to this as they can quantitatively simulate the interaction of α-particles with the target(s). Read More

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December 2018

Insurance Approval for Proton Beam Therapy and its Impact on Delays in Treatment.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ. Electronic address:

Purpose: Prior authorization (PA) has been widely implemented for proton beam therapy (PBT). We sought to determine the association between PA determination and patient characteristics, practice guidelines, and potential treatment delays.

Methods And Materials: A single-institution retrospective analysis was performed of all patients considered for PBT between 2015 and 2018 at a National Cancer Institute-designated Comprehensive Cancer Center. Read More

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December 2018

Early toxicity of a phase II trial of combined salvage radiotherapy and hormone therapy in oligometastatic pelvic node relapses of prostate cancer (OLIGOPELVIS GETUG P07).

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Institut de Cancérologie de l`Ouest, Boulevard J. Monod, F-44800 Nantes, St-Herblain France; Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), UMR 1232 Inserm - 6299 CNRS, Institut de Recherche en Santé de l`Université de Nantes, 8 quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France. Electronic address:

Purpose: Limited pelvic nodal relapse of prostatic cancer is a paramount challenge for locoregional salvage treatments. Salvage whole pelvis radiotherapy as considered in the BLINDED trial, is an attractive option but with concerns about its toxicity. This article describes early toxicity with the technique. Read More

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December 2018

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, 3060-197, Cantanhede, Portugal. Electronic address:

Dose-dependent and cumulative cardiotoxicity associated with doxorubicin (DOX) is the main limitation of anticancer therapy. Pediatric cancer survivors are particularly vulnerable, and no effective prevention measures are available. The aim of the present study was to investigate the persistent effects of nanomolar DOX concentrations and determine whether a pretreatment would induce mitochondrial adaptations in H9c2 cardiomyoblasts. Read More

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December 2018

Comprehensive identification of protein disulfide bonds with pepsin/trypsin digestion, Orbitrap HCD and Spectrum Identification Machine.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Proteomics Research and Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School and Cancer Institute of New Jersey, Newark, NJ 07103, USA. Electronic address:

Disulfide bonds (SS) are post-translational modifications important for the proper folding and stabilization of many cellular proteins with therapeutic uses, including antibodies and other biologics. With budding advances of biologics and biosimilars, there is a mounting need for a robust method for accurate identification of SS. Even though several mass spectrometry methods have emerged for this task, their practical use rests on the broad effectiveness of both sample preparation methods and bioinformatics tools. Read More

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December 2018

A papilloma in a large cyst of the breast: A case report.

Int J Surg Case Rep 2018 Nov 16;55:1-3. Epub 2018 Nov 16.

Department of Pediatric, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, South Korea. Electronic address:

Introduction: Intracystic lesions of the breast prove to be benign more often than malignancy, most intracystic lesions are benign papillomas. Generally sizes of cysts that contain papilloma are small. Relatively cysts that contain papillary carcinoma are large. Read More

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November 2018

Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice.

J Control Release 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy. Electronic address:

Extracellular vesicles (EVs), are naturally occurring cargo delivery tools with the potential to be used as drug vehicles of single agents or combination therapies. We previously demonstrated that human lung cancer cell-derived EVs could be used for the systemic delivery of oncolytic virus (OVs) and chemotherapy drugs such as paclitaxel (PTX), leading to enhanced anti-tumor effects in nude mice. In the current work, we evaluated the biodistribution of EVs by using bioluminescence and fluorescence imaging technologies, thus proving the ability of these EVs-formulations to specifically target the neoplasia, while leaving other body tissues unaffected. Read More

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December 2018

Detection of high-risk human papillomavirus DNA in tissue from primary cervical cancer tumor, pelvic lymph nodes and recurrent disease.

Papillomavirus Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.

Objectives: The present study investigated Human Papillomavirus (HPV) DNA genotyping in primary tumor, pelvic lymph nodes (PLN) and recurrence in early-stage cervical cancer patients.

Methods: We conducted a hospital-based case-control study. From 2003 to 2015, 282 patients underwent surgery for cervical cancer in the Department of Gynecology, Aarhus University Hospital, Denmark. Read More

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December 2018

Effective Effectors: How T cells Access and Infiltrate the Central nervous System.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710., United States; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710., United States; Department of Neurosurgery, Duke University School of Medicine, Durham, NC 27710., United States; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27710, United States; Department of Pathology, Duke University School of Medicine, Durham, NC 27710., United States. Electronic address:

Several Phase II and III clinical trials have demonstrated that immunotherapy can induce objective responses in otherwise refractory malignancies in tumors outside the central nervous system. In large part, effector T cells mediate much of the antitumor efficacy in these trials, and potent antitumor T cells can be generated through vaccination, immune checkpoint blockade, adoptive transfer, and genetic manipulation. However, activated T cells must still traffic to, infiltrate, and persist within tumor in order to mediate tumor lysis. Read More

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December 2018

KIT as a therapeutic target for non-oncological diseases.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Aix Marseille Université, INSERM, INRA, C2VN, Marseille, France; Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-, HM, Marseille, France.. Electronic address:

KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT. Read More

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December 2018

Induced Pluripotent Stem Cells: A New Strategy to Model Human Cancer.

Int J Biochem Cell Biol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory for Cancer Biology, Department of Medical Oncology and Clinical Research, Cancer Institute (WIA), Chennai, India. Electronic address:

Induced pluripotent stem cells are derived from adult somatic cells by ectopic expression of stem cell factors OCT4, SOX2, MYC and KLF4. These cells have characteristic features similar to embryonic stem cells. Although there exists in vitro and in vivo models of cancer, recapitulating the earliest events in the pathogenesis remain challenging. Read More

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December 2018

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.

Free Radic Biol Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China; Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China. Electronic address:

Dihydroartemisinin (DHA) has been shown to be capable of inhibiting cancer growth, whereas it remains largely elusive that the underlying molecular mechanism of DHA induced acute myeloid leukemia (AML) cell death. In the present study, we examined the effects of DHA on the proliferation and ferroptosis of AML cells as well as to elucidate the underlying molecular mechanisms. We found that DHA strongly inhibited the viability of AML cell lines and arrest cell cycle at G0/G1 phase. Read More

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December 2018

TCF7L2 and EGR1 synergistic activation of transcription of LCN2 via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma cells.

Cell Signal 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Genes Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:

High level expression of lipocalin 2 (LCN2) usually indicates poor prognosis in esophageal squamous cell carcinoma (ESCC) and many other cancers. Our previous study showed LCN2 promotes migration and invasion of ESCC cells through a novel positive feedback loop. However, the key transcription activation protein (KTAP) in the loop had not yet been identified. Read More

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December 2018

In response to: "New validated diagnostic criteria for pyoderma gangrenosum".

J Am Acad Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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December 2018

Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

Antiviral Res 2018 Dec 14. Epub 2018 Dec 14.

Aix-Marseille Université, CNRS UMR 7257, Architecture et Fonction des Macromolécules Biologiques, 163 avenue de Luminy, 13288, Marseille, France. Electronic address:

Arenaviridae is a viral family whose members are associated with rodent-transmitted infections to humans responsible of severe diseases. The current lack of a vaccine and limited therapeutic options make the development of efficacious drugs of high priority. The cap-snatching mechanism of transcription of Arenavirus performed by the endonuclease domain of the L-protein is unique and essential, so we developed a drug design program targeting the endonuclease activity of the prototypic Lymphocytic ChorioMeningitis Virus. Read More

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December 2018

Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting.

Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Lung cancer remains the leading cause of cancer-related deaths despite recent breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has also been applied for lung cancer, postulating that an often small proportion of tumor cells with stem cell properties are responsible for tumor growth, therapeutic resistance and metastasis. The identification of these CSCs and underlying molecular maintenance mechanisms is considered to be absolutely necessary for developing therapies for their riddance, hence achieving remission. Read More

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December 2018

Safety of robotic-assisted gynecologic surgery and early hospital discharge in elderly patients.

Am J Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

New York University Langone Medical Center. Electronic address:

Background: A minimally invasive surgical approach has proven to decrease peri- and post-operative complications and shorten duration of hospital stay, however there is limited data evaluating the safety of robotic-assisted surgery and early hospital discharge in the elderly population. As age is a well-known, independent risk factor for peri-operative morbidity and gynecologists treat many elderly patients, this is an important area of study.

Objective: To evaluate discharge timing and surgical outcomes in elderly compared to younger patients undergoing robotic-assisted gynecologic surgery. Read More

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December 2018
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Long non-coding RNA Hotair promotes gastric cancer progression via miR-217-GPC5 axis.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China. Electronic address:

Aims: The oncogenic role of lncRNA Hotair has been acknowledged in subset of malignancies, including gastric cancer (GC). However, the detailed molecular mechanisms that contribute to its oncogenic role of are largely elusive. This study was designed to explore the underlying mechanism that contributes the regulatory role of Hotair in GC pathogenesis and progression. Read More

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December 2018

Fluvastatin-mediated down-regulation of SATB1 affects aggressive phenotypes of human non-small-cell lung cancer cell line H292.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Aims: Fluvastatin reduces tumor proliferation and increased apoptotic activity in various cancers. Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that reprogrammes the gene transcription profiles of tumors to promote growth and metastasis. The antitumor effect and molecular mechanisms of fluvastatin on lung cancer is poorly understood. Read More

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December 2018

The Optimal Treatment for Stage IIIA-N2 Non-small-cell Lung Cancer: A Network Meta-analysis.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China. Electronic address:

Background: The optimal treatment for stage IIIA-N2 non-small-cell lung cancer (NSCLC) is controversial. We aimed to address this important issue through a Bayesian network meta-analysis.

Methods: We performed a search of electronic databases for randomized controlled trials comparing the following treatments: surgery, radiotherapy, chemotherapy and their multiple combinations before March 25, 2018. Read More

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December 2018

Physician gender differences in processing surgical risk features in videos of standardized patients.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, University of Chicago.

Background: Physician gender differences exist for estimating surgical risk and recommending lung resection. We assessed gender differences in perceived importance of health characteristics portrayed by standardized patients posing as lung resection candidates.

Methods: Physicians read a clinical vignette categorized as low, average, or high surgical risk, then viewed a video of a standardized patient exhibiting vigorous, normal, or frail behavior. Read More

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December 2018

Mediastinoscopy for staging of Non-Small Cell Lung Cancer: surgical performance in the Netherlands.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Northwest Clinics, Alkmaar, the Netherlands.

Background: To determine optimal treatment options in non-small cell lung cancer (NSCLC), accurate staging of the mediastinal lymph nodes is of great importance. In case of suspected mediastinal metastases, EUS/EBUS combined with mediastinoscopy is the gold standard. Diagnostic value of these procedures stands or falls by how they are technically performed. Read More

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December 2018

A Novel Approach for Total Nasal Reconstruction.

J Oral Maxillofac Surg 2018 Nov 22. Epub 2018 Nov 22.

Assistant Clinical Professor, Department of Oral and Maxillofacial Surgery, Louisiana State University Health and Sciences Center, New Orleans, LA.

A 61-year-old woman who lost her nose, upper lip, and most of her midface bony structures because of cancer 20 years previously underwent advanced surgical reconstruction. This patient previously underwent multiple reconstructive surgeries that failed to satisfactorily restore her nose. Therefore, a multistage reconstruction was performed to recreate a complete nose and increase her upper lip length. Read More

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November 2018

Evaluation of metabolite-microbe correlation detection methods.

Anal Biochem 2018 Dec 14. Epub 2018 Dec 14.

Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. Electronic address:

Different correlation detection methods have been specifically designed for the microbiome data analysis considering the compositional data structure and different sequencing depths. Along with the speedy development of omics studies, there is an increasing interest in discovering the biological associations between microbes and host metabolites. This raises the need of finding proper statistical methods that facilitate the correlation analysis across different omics studies. Read More

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December 2018

Transformation of Prostate Adenocarcinoma Into Small-Cell Neuroendocrine Cancer Under Androgen Deprivation Therapy: Much Is Achieved But More Information Is Needed.

J Clin Oncol 2018 Dec 17:JCO1801055. Epub 2018 Dec 17.

Alberto Dalla Volta, MD; Deborah Cosentini, MD; Alessandro Antonelli, MD; Rebecca Pedersini, MD; Claudio Simeone, MD; and Alfredo Berruti, MD, University of Brescia, Spedali Civili Hospital, Brescia, Italy; and Marco Volante, MD, PhD, University of Turin, Turin, Italy.

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December 2018

T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.

J Clin Oncol 2018 Dec 13:JCO2018782276. Epub 2018 Dec 13.

Patrick A. Ott, Dana-Farber Cancer Institute, Boston, MA; Yung-Jue Bang, Seoul National University College of Medicine, Seoul, The Republic of Korea; Sarina A. Piha-Paul, University of Texas MD Anderson Cancer Center, Houston, TX; Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Jaafar Bennouna, Centre Hospitalier Universitaire Nantes, Nantes; Jean-Charles Soria, University Paris-Sud and Gustave Roussy, Villejuif, France; Hope S. Rugo, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Roger B. Cohen, University of Pennsylvania, Philadelphia, PA; Bert H. O'Neil, Indiana University, Bloomington, IN; Janice M. Mehnert, Rutgers Cancer Institute of New Jersey, New Brunswick; Razvan Cristescu, Ping Yang, Kenneth Emancipator, Karen Stein, Mark Ayers, Andrew K. Joe, and Jared K. Lunceford, Merck & Co., Inc., Kenilworth, NJ; Juanita Lopez, Institute of Cancer Research, London, United Kingdom; Toshihiko Doi, National Cancer Center Hospital East, Chiba, Japan; and Emilie M.J. van Brummelen, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

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December 2018
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