18,429 results match your criteria Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Preventive Oncology[Journal]


Dietary inflammatory index is positively associated with serum high-sensitivity C-reactive protein in a Korean adult population.

Nutrition 2018 Nov 23;63-64:155-161. Epub 2018 Nov 23.

Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA; Connecting Health Innovations LLC, Columbia, South Carolina, USA.

Objective: To our knowledge, only a few studies have explored the relationship between the inflammatory potential of diet and serum inflammatory markers in Korean adults. The likely novel aim of this study was to examine the association between the dietary inflammatory index (DII) and serum high-sensitivity C-reactive protein (hs-CRP) in a Korean adult population.

Methods: A cross-sectional study was conducted using the data set from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015. Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.016DOI Listing
November 2018

Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China;

Background: Reliable noninvasive biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis are urgently needed. We explored the potential of not only microRNAs (miRNAs) but other types of noncoding RNAs (ncRNAs) as HCC biomarkers.

Methods: Peripheral blood samples were collected from 77 individuals; among them, 57 plasma cell-free RNA transcriptomes and 20 exosomal RNA transcriptomes were profiled. Read More

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http://dx.doi.org/10.1373/clinchem.2018.301150DOI Listing

Early infection with cytomegalovirus and risk of childhood hematological malignancies.

Cancer Epidemiol Biomarkers Prev 2019 Apr 17. Epub 2019 Apr 17.

Institute of Environmental Medicine, Unit of Epidemiology, Karolinska Institute.

Background: Congenital cytomegalovirus (CMV) infection was recently identified as a risk factor for childhood acute lymphocytic leukemia by detecting the presence of CMV sequences in neonatal blood spots. In the current study, we asked whether clinically apparent CMV infection could be identified prior to hematological malignancy, using high quality Swedish population-based registries.

Methods: CMV infection was identified with appropriate ICD-9 or ICD-10 codes in the Patient and Medical Birth Registries, and childhood malignancies below the age of 15 were identified in the Cancer Registry, among 2,782,507 children born in Sweden 1987 to 2014. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-19-0044DOI Listing

Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study.

Breast Cancer Res 2019 Apr 17;21(1):50. Epub 2019 Apr 17.

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, UPMC Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA, 15232, USA.

Background: Telomeres and telomerase play key roles in the chromosomal maintenance and stability. Recent epidemiological studies have shown that longer telomeres are associated with increased risk of several cancer types. However, epidemiological data for telomere length and risk of breast cancer are sparse. Read More

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http://dx.doi.org/10.1186/s13058-019-1133-0DOI Listing

New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1.

Int J Biol Markers 2019 Apr 17:1724600819834235. Epub 2019 Apr 17.

5 Division of Laboratory Medicine, Humanitas Clinical and Research Center, IRCCS, Rozzano Milan, Italy.

Background: Testing for circulating biomarkers in lung cancer is hampered by the insufficient specificity. We aimed to assess the relative diagnostic accuracy of pro-gastrin-releasing peptide (ProGRP) for the differential diagnosis of small cell lung cancer and compare it with more conventional biomarkers.

Methods: We enrolled a cohort of 390 patients with a clinical suspicion of lung cancer and for whom a histologic assessment was available. Read More

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http://dx.doi.org/10.1177/1724600819834235DOI Listing

Impact of combined healthy lifestyle factors on survival in an adult general population and in high-risk groups: prospective results from the Moli-sani Study.

J Intern Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.

Background: There is poor knowledge on the association between combined lifestyles with mortality risk among individuals at high risk, and little is known on the biological mechanisms that could be on the pathway.

Methods: Longitudinal analysis on 22 839 individuals from the Moli-sani Study (Italy, 2005-2010). Among them, we identified 5200 elderly individuals (≥65 year), 2127 subjects with diabetes and 1180 with cardiovascular disease (CVD) at baseline. Read More

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http://dx.doi.org/10.1111/joim.12907DOI Listing

Investigating the diagnostic performance of HOTTIP, PVT1, and UCA1 long noncoding RNAs as a predictive panel for the screening of colorectal cancer patients with lymph node metastasis.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, hahid Beheshti University of Medical Sciences, Tehran, Iran.

Like other noncoding RNAs (ncRNAs), dysregulation of long ncRNAs (lncRNAs) has been associated with various clinicopathological features of colorectal cancer (CRC) patients such as lymph node metastasis (LNM). Recently, three aberrant expressed oncogenic lncRNA (onco-lncRNAs), including HOXA transcript at the distal tip (HOTTIP), plasmacytoma variant translocation 1 (PVT1), and urothelial carcinoma associated 1 (UCA1) have been reported in LNM. Herein, we compared the diagnostic performance of these lncRNAs as individual biomarkers and as a discriminating panel between LNM CRC patients, nonmetastatic lymph nodes (NLN) and normal healthy subjects. Read More

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http://dx.doi.org/10.1002/jcb.28739DOI Listing

Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach.

Eur J Epidemiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

Chronological age alone is not a sufficient measure of the true physiological state of the body. The aims of the present study were to: (1) quantify biological age based on a physiological biomarker composite model; (2) and evaluate its association with death and age-related disease onset in the setting of an elderly population. Using structural equation modeling we computed biological age for 1699 individuals recruited from the first and second waves of the Rotterdam study. Read More

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http://dx.doi.org/10.1007/s10654-019-00497-3DOI Listing

Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients.

Leukemia 2019 Apr 16. Epub 2019 Apr 16.

Myeloma Research Group, Australian Centre for Blood Diseases, Alfred Hospital-Monash University, Melbourne, VIC, Australia.

Monitoring tumour burden and therapeutic response through analyses of circulating cell-free tumour DNA (ctDNA) and extracellular RNA (exRNA) in multiple myeloma (MM) patients were performed in a Phase Ib trial of 24 relapsed/refractory patients receiving oral azacitidine in combination with lenalidomide and dexamethasone. Mutational characterisation of paired BM and PL samples at study entry identified that patients with a higher number of mutations or a higher mutational fractional abundance in PL had significantly shorter overall survival (OS) (p = 0.005 and p = 0. Read More

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http://dx.doi.org/10.1038/s41375-019-0469-xDOI Listing

Putative biomarkers of malignant transformation of sinonasal inverted papilloma into squamous cell carcinoma.

J Int Med Res 2019 Apr 16:300060519838385. Epub 2019 Apr 16.

1 Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To compare genome-wide DNA methylation between samples of sinonasal inverted papilloma (SNIP) and squamous cell carcinoma (SCC) samples in order to identify aberrantly methylated genes that might be involved in malignant transformation.

Methods: Tissue samples were collected from patients. DNA methylation in C-phosphate-G islands and gene promoters was analysed using a DNA methylation microarray kit. Read More

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http://dx.doi.org/10.1177/0300060519838385DOI Listing

Identification of Novel Circulating MicroRNA Biomarkers for the Diagnosis of Esophageal Squamous Cell Carcinoma and Squamous Dysplasia.

Cancer Epidemiol Biomarkers Prev 2019 Apr 15. Epub 2019 Apr 15.

Epidemiology and Health Statistics, Capital Medical University

Background: Circulating microRNAs (miRNAs) have been identified as diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC), but their efficacy in discovering early-stage ESCC is still unsatisfying. Esophageal squamous dysplasia (ESD) is the precursor lesion of ESCC. Notably, little is known about the role(s) of circulating miRNAs in identifying ESD. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1199DOI Listing

A Review of Defined Oxidative Balance Scores Relative to Their Components and Impact on Health Outcomes.

Nutrients 2019 Apr 3;11(4). Epub 2019 Apr 3.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

Oxidative Balance Scores (OBSs) are tools that have emerged to evaluate the global balance of individuals' oxidation-reduction status. The aim was to compare OBSs available in the literature regarding their characteristics and associations with chronic diseases in epidemiological studies. Studies that developed OBSs were searched in PubMed until August 2018. Read More

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http://dx.doi.org/10.3390/nu11040774DOI Listing

The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection.

Papillomavirus Res 2019 Apr 12. Epub 2019 Apr 12.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa. Electronic address:

In this study we examined potential associations of HPV infection with the cervical microbiota. Cervical samples were collected from 87 HIV-seronegative reproductive-age Black South African women. Microbiota were characterized by Illumina sequencing of the V3-V4 hypervariable regions of the bacterial 16S rRNA gene. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.04.006DOI Listing

Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer.

World J Gastroenterol 2019 Apr;25(13):1580-1591

The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Background: Early gastric cancer (EGC), compared with advanced gastric cancer (AGC), has a higher 5-year survival rate. However, due to the lack of typical symptoms and the difficulty in diagnosing EGC, no effective biomarkers exist for the detection of EGC, and gastroscopy is the only detection method.

Aim: To provide new biomarkers with high specificity and sensitivity through analyzed the differentially expressed microRNAs (miRNAs) in EGC and AGC and compared them with those in benign gastritis (BG). Read More

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http://dx.doi.org/10.3748/wjg.v25.i13.1580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452233PMC
April 2019
1 Read
2.369 Impact Factor

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis.

Clin Epigenetics 2019 Apr 11;11(1):62. Epub 2019 Apr 11.

Department of Epidemiology and Preventive Medicine, Monash University, ASPREE, Level 5, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria, 3004, Australia.

Background: Ageing is one of the principal risk factors for many chronic diseases. However, there is considerable between-person variation in the rate of ageing and individual differences in their susceptibility to disease and death. Epigenetic mechanisms may play a role in human ageing, and DNA methylation age biomarkers may be good predictors of age-related diseases and mortality risk. Read More

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http://dx.doi.org/10.1186/s13148-019-0656-7DOI Listing
April 2019
1 Read

LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics.

Cancers (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Division of Cancer Epidemiology and Prevention, National Cancer Center, Madu-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Korea.

Cervical cancer remains one of the most prevalent cancers among females worldwide. Therefore, it is important to discover new biomarkers for early diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer, preferably non-invasive ones. In the present study, we aimed to identify unique metabolic signatures for CINs and cervical cancers using global and targeted metabolomic profiling. Read More

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https://www.mdpi.com/2072-6694/11/4/511
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http://dx.doi.org/10.3390/cancers11040511DOI Listing
April 2019
3 Reads

Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards.

Occup Environ Med 2019 Apr 10. Epub 2019 Apr 10.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland, USA.

Objectives: The occupational exposure limit for trichloroethylene (TCE) in different countries varies from 1 to 100 ppm as an 8-hour time-weighted average (TWA). Many countries currently use 10 ppm as the regulatory standard for occupational exposures, but the biological effects in humans at this level of exposure remain unclear. The objective of our study was to evaluate alterations in immune and renal biomarkers among workers occupationally exposed to low levels of TCE below current regulatory standards. Read More

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http://dx.doi.org/10.1136/oemed-2018-105583DOI Listing
April 2019
3.267 Impact Factor

Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies.

Circulation 2019 Apr 11. Epub 2019 Apr 11.

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.

Background: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies.

Methods: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038908DOI Listing
April 2019
3 Reads
14.430 Impact Factor

The association of bone, fingernail and blood manganese with cognitive and olfactory function in Chinese workers.

Sci Total Environ 2019 May 21;666:1003-1010. Epub 2019 Feb 21.

School of Health Sciences, Purdue University, West Lafayette, IN, USA; Public Health Graduate Program, Purdue University, West Lafayette, IN, USA. Electronic address:

Occupational manganese (Mn) exposure has been associated with cognitive and olfactory dysfunction; however, few studies have incorporated cumulative biomarkers of Mn exposure such as bone Mn (BnMn). Our goal was to assess the cross-sectional association between BnMn, blood Mn (BMn), and fingernail Mn (FMn) with cognitive and olfactory function among Mn-exposed workers. A transportable in vivo neutron activation analysis (IVNAA) system was designed and utilized to assess BnMn among 60 Chinese workers. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461352PMC

Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC Cohort.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France.

Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this association are not fully elucidated, particularly the extent to which this relationship is mediated by sex hormone levels. Circulating concentrations of estradiol, testosterone, their free fractions and sex-hormone binding globulin (SHBG), were examined in 430 incident BC cases and 645 matched controls among alcohol-consuming postmenopausal women nested within the European Prospective Investigation into Cancer and Nutrition. Mediation analysis was applied to assess whether individual hormone levels mediated the relationship between alcohol intake and BC risk. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32324
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http://dx.doi.org/10.1002/ijc.32324DOI Listing
April 2019
5 Reads

Gene amplification derived a cancer-testis long noncoding RNA PCAT6 regulates cell proliferation and migration in hepatocellular carcinoma.

Cancer Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Our previous work demonstrated cancer-testis (CT) genes as a new source of candidate driver of cancer. Recently, mounting evidence indicates that long noncoding RNAs (lncRNAs) with CT expression pattern could play a pivotal role in cancer biology. Here, we characterized a conserved CT long noncoding RNA (CT-lncRNA), PCAT6, which is expressed exclusively in the testis and is reactivated in liver hepatocellular carcinoma (LIHC) tissues due to the highly frequent amplification. Read More

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http://dx.doi.org/10.1002/cam4.2141DOI Listing

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.

Leukemia 2019 Apr 9. Epub 2019 Apr 9.

ProfilExpert, Lyon, France.

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http://dx.doi.org/10.1038/s41375-019-0452-6DOI Listing
April 2019
1 Read

Titrating Complex Mass Cytometry Panels.

Cytometry A 2019 Apr 9. Epub 2019 Apr 9.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

We describe here a simple and efficient antibody titration approach for cell-surface markers and intracellular cell signaling targets for mass cytometry. The iterative approach builds upon a well-characterized backbone panel of antibodies and analysis using bioinformatic tools such as SPADE. Healthy peripheral blood and bone marrow cells are stained with a pre-optimized "backbone" antibody panel in addition to the progressively diluted (titrated) antibodies. Read More

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http://dx.doi.org/10.1002/cyto.a.23751DOI Listing

Longitudinal investigation of haematological alterations among permethrin-exposed pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture study.

Occup Environ Med 2019 Apr 8. Epub 2019 Apr 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Objectives: Permethrin use has been associated with an increased risk of multiple myeloma (MM) among pesticide applicators. However, the biological plausibility and mechanisms underlying this association are not fully understood. The aim of this study was to assess whether exposure to permethrin is related to haematological alterations among occupationally exposed pesticide applicators. Read More

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http://dx.doi.org/10.1136/oemed-2018-105559DOI Listing
April 2019
1 Read

Circulating microRNAs in plasma among men with low-grade and high-grade prostate cancer at prostate biopsy.

Prostate 2019 Apr 8. Epub 2019 Apr 8.

Department of Population Health Science and Policy, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: MicroRNAs (miRNAs or miR-) have been linked to factors associated with aggressive prostate cancer such as biochemical recurrence and metastasis. We investigated whether circulating miRNAs in plasma could be used as diagnostic biomarkers for more aggressive prostate cancer at prostate biopsy.

Methods: Men, aged 40 years and above, newly diagnosed with prostate cancer were categorized into two risk groups, low-grade (Gleason score, 6 or 7 [3 + 4] and serum prostate-specific antigen [PSA], <20 ng/mL) and high-grade (Gleason score, ≥7 (4 + 3) and serum PSA, ≥20 ng/mL) prostate cancers. Read More

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http://dx.doi.org/10.1002/pros.23803DOI Listing

Clinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours.

Tumour Biol 2019 Apr;42(4):1010428319835684

1 Unidad de Investigación, Hospital Costa del Sol, REDISSEC, Marbella, España.

We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p < 0.001). Read More

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http://dx.doi.org/10.1177/1010428319835684DOI Listing

Prioritized concordance index for hierarchical survival outcomes.

Stat Med 2019 Apr 7. Epub 2019 Apr 7.

Division of Cancer Epidemiology and Genetics, NIH National Cancer Institute, Rockville, MD.

We propose an extension of Harrell's concordance (C) index to evaluate the prognostic utility of biomarkers for diseases with multiple measurable outcomes that can be prioritized. Our prioritized concordance index measures the probability that, given a random subject pair, the subject with the worst disease status as of a time τ has the higher predicted risk. Our prioritized concordance index uses the same approach as the win ratio, by basing generalized pairwise comparisons on the most severe or clinically important comparable outcome. Read More

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http://dx.doi.org/10.1002/sim.8157DOI Listing

Shortcomings in the evaluation of biomarkers in ovarian cancer: a systematic review.

Clin Chem Lab Med 2019 Apr 8. Epub 2019 Apr 8.

Amsterdam University Medical Centers, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Background Shortcomings in study design have been hinted at as one of the possible causes of failures in the translation of discovered biomarkers into the care of ovarian cancer patients, but systematic assessments of biomarker studies are scarce. We aimed to document study design features of recently reported evaluations of biomarkers in ovarian cancer. Methods We performed a systematic search in PubMed (MEDLINE) for reports of studies evaluating the clinical performance of putative biomarkers in ovarian cancer. Read More

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http://dx.doi.org/10.1515/cclm-2019-0038DOI Listing
April 2019
1 Read

Commentary: Premalignant genomic data tracing the evolution of lung adenocarcinoma.

EBioMedicine 2019 Apr 4. Epub 2019 Apr 4.

Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.065DOI Listing

Efficacy of combined VEGFR1-3, PDGFα/β, and FGFR1-3 blockade using nintedanib for esophagogastric cancer.

Clin Cancer Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College

Purpose: Vascular endothelial growth factor receptor 2 (VEGFR2)-directed therapy is commonly used to treat metastatic esophagogastric cancer, but disease progresses in most patients within months. Therapeutic resistance is likely mediated in part by co-occurring amplifications of the genes for multiple oncogenic receptor tyrosine kinases. We therefore tested the efficacy of combined inhibition of VEGFR1-3, PDGFα/β, and FGFR1-3 using nintedanib. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3789DOI Listing
April 2019
4 Reads

A genetic variation in the CpG island of pseudogene GBAP1 promoter is associated with gastric cancer susceptibility.

Cancer 2019 Apr 5. Epub 2019 Apr 5.

Department of Environmental Genomics, Center for Global Health, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.

Background: Previous genome-wide association studies (GWASs) have identified that several single nucleotide polymorphisms (SNPs) are implicated in gastric cancer (GC) risk. However, the multiple statistical comparisons of GWASs may reject some true biological positives with subthreshold P values.

Methods: This study annotated the genomic locations of all CpG islands in the genome using the Encyclopedia of DNA Elements (ENCODE). Read More

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http://dx.doi.org/10.1002/cncr.32081DOI Listing

Using recursive partitioning approach to select tumor-associated antigens in immunodiagnosis of gastric adenocarcinoma.

Cancer Sci 2019 Apr 5. Epub 2019 Apr 5.

Department of Epidemiology and Health statistics & Henan Key Laboratory for Tumor Epidemiology, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, China.

This study aimed to select anti-TAAs autoantibodies as biomarkers in immunodiagnosis of gastric adenocarcinoma (GAC) by recursive partitioning approach (RPA), and further construct and evaluate predictive model. A case-control study was designed, including 407 GAC patients as case group and 407 normal controls. In addition, 67 serial serum samples from 25 GAC patients were collected at different time points before and after gastrectomy treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14013
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http://dx.doi.org/10.1111/cas.14013DOI Listing
April 2019
6 Reads

Immune marker changes and risk of multiple myeloma: a nested case-control study using repeated prediagnostic blood samples.

Haematologica 2019 Apr 4. Epub 2019 Apr 4.

Department of Radiation Sciences, Oncology, Umeå University, Sweden.

Biomarkers reliably predicting progression to multiple myeloma are lacking. Myeloma risk has been associated with low blood levels of monocyte chemotactic protein 3, macrophage inflammatory protein 1 alpha, vascular endothelial growth factor, fibroblast growth factor 2, fractalkine, and transforming growth factor alpha. In this study, we aimed to replicate these findings and study the individual dynamics of each marker in a prospective longitudinal cohort, thereby examining their potential as markers of myeloma progression. Read More

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http://dx.doi.org/10.3324/haematol.2019.216895DOI Listing

Predicting circulating CA125 levels among healthy premenopausal women.

Cancer Epidemiol Biomarkers Prev 2019 Apr 4. Epub 2019 Apr 4.

Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School.

Background: CA125 is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1120DOI Listing
April 2019
3 Reads

Genome-wide analysis of common copy number variation and epithelial ovarian cancer risk.

Cancer Epidemiol Biomarkers Prev 2019 Apr 4. Epub 2019 Apr 4.

Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute

Background: Germline DNA copy number variation (CNV) is a ubiquitous source of genetic variation and remains largely unexplored in association with epithelial ovarian cancer (EOC) risk.

Methods: CNV was quantified in the DNA of approximately 3500 cases and controls genotyped with the Illumina 610k and HumanOmni2.5M arrays. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0833DOI Listing
April 2019
4 Reads

Association of Long Non-Coding RNA MEG3 Polymorphisms with Oral Squamous Cell Carcinoma Risk.

Oral Dis 2019 Apr 4. Epub 2019 Apr 4.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Objective: Long non-coding RNA (lncRNA) MEG3 was associated with multiple types of cancers such as Oral squamous cell carcinoma (OSCC). Single nucleotide polymorphisms (SNPs) might affect cancer risk by modified the function of lncRNAs. But fewer study researched the relationship between SNPs and MEG3 in cancers. Read More

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http://dx.doi.org/10.1111/odi.13103DOI Listing
April 2019
1 Read

Disparities in Cancer Incidence among Chinese Population versus Migrants to Developed Regions: A Population-Based Comparative Study.

Cancer Epidemiol Biomarkers Prev 2019 Apr 3. Epub 2019 Apr 3.

State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.

The incidence of cancer was determined by genetic and environmental factors and varied across the world. The discrepancies in cancer profile among Chinese people living in different regions remained obscure. Chinese people living in urban Shanghai, Hong Kong, Taiwan, Macau, Singapore, and Los Angeles were included in this study. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0827DOI Listing
April 2019
6 Reads
4.125 Impact Factor

Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients.

Mol Carcinog 2019 Apr 2. Epub 2019 Apr 2.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammation, and contribute to colorectal carcinogenesis. We investigated supplemental calcium (1200 mg, daily) and/or vitamin D (1000 IU daily) effects on intestinal barrier function-related biomarkers in a subset of 105 participants from a large colorectal adenoma recurrence chemoprevention clinical trial. Read More

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http://dx.doi.org/10.1002/mc.23010DOI Listing
April 2019
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Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.

Nat Med 2019 Apr 1;25(4):667-678. Epub 2019 Apr 1.

Department CIBIO, University of Trento, Trento, Italy.

Several studies have investigated links between the gut microbiome and colorectal cancer (CRC), but questions remain about the replicability of biomarkers across cohorts and populations. We performed a meta-analysis of five publicly available datasets and two new cohorts and validated the findings on two additional cohorts, considering in total 969 fecal metagenomes. Unlike microbiome shifts associated with gastrointestinal syndromes, the gut microbiome in CRC showed reproducibly higher richness than controls (P < 0. Read More

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http://www.nature.com/articles/s41591-019-0405-7
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http://dx.doi.org/10.1038/s41591-019-0405-7DOI Listing
April 2019
11 Reads

Genome-wide copy number alteration and VEGFA amplification of circulating cell-free DNA as a biomarker in advanced hepatocellular carcinoma patients treated with Sorafenib.

BMC Cancer 2019 Apr 1;19(1):292. Epub 2019 Apr 1.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Background: Although sorafenib is the global standard first-line systemic treatment for unresectable hepatocellular carcinoma (HCC), it does not have reliable predictive or prognostic biomarkers. Circulating cell-free DNA (cfDNA) has shown promise as a biomarker for various cancers. We investigated the use of cfDNA to predict clinical outcomes in HCC patients treated with sorafenib. Read More

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http://dx.doi.org/10.1186/s12885-019-5483-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444867PMC
April 2019
2 Reads
3.362 Impact Factor

Cancer Survivorship and Subclinical Myocardial Damage: The Atherosclerosis Risk in Communities (ARIC) Study.

Am J Epidemiol 2019 Mar 30. Epub 2019 Mar 30.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Cancer survivors may have an excess risk of cardiovascular disease (CVD) resulting from toxicities of cancer therapies and high burden of CVD risk factors. We sought to evaluate the association of cancer survivorship with subclinical myocardial damage, as assessed by elevated high-sensitivity cardiac Troponin T (hs-cTnT). We included 3,512 participants of the ARIC Study who attended Visit 5 (2011-2013) and were free of CVD (coronary heart disease, heart failure, or stroke). Read More

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http://dx.doi.org/10.1093/aje/kwz088DOI Listing
March 2019
1 Read
5.230 Impact Factor

Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis.

Neurology 2019 Mar 29. Epub 2019 Mar 29.

From the Departments of Nutrition (K.B., Z.Z., É.J.O., D.D.W., A.A.) and Epidemiology (L.L., J.E.M., A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), College of Medicine, University College Cork, Ireland; Department of Neurology (J.D.B., M.A.S.), Massachusetts General Hospital, Boston; Metabolomics Platform (C.B.C., A.D., S.J., K.A.P.), Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA; Department of Oncology (I.K.), Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI; Channing Division of Network Medicine (R.S.K., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Epidemiology Program (L.N.K., L.L.M.), University of Hawaii Cancer Center, Honolulu; Behavioral and Epidemiology Research Group (M.L.M.), American Cancer Society, Atlanta, GA; Department of Physical Medicine and Rehabilitation (S.P.), Spaulding Rehabilitation Hospital and Massachusetts General Hospital; Harvard Medical School (S.P., M.A.S.), Boston, MA; Family Medicine and Public Health (A.H.S.), School of Medicine, University of California San Diego; Epidemiology and Environmental Health, Public Health and Health Professions (J.W.-W.), University at Buffalo, NY; Behavioral and Epidemiology Research Group (Y.W.), American Cancer Society, Atlanta, GA; and Department of Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objective: To identify prediagnostic plasma metabolomic biomarkers associated with amyotrophic lateral sclerosis (ALS).

Methods: We conducted a global metabolomic study using a nested case-control study design within 5 prospective cohorts and identified 275 individuals who developed ALS during follow-up. We profiled plasma metabolites using liquid chromatography-mass spectrometry and identified 404 known metabolites. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007401DOI Listing
March 2019
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Body shape trajectories and incidence of depression in the "Seguimiento Universidad de Navarra" (SUN) prospective cohort.

J Affect Disord 2019 Mar 19;251:170-179. Epub 2019 Mar 19.

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain; Centro de Investigacion Biomedica en Red Area de Fisiologia de la Obesidad y la Nutricion (CIBEROBN), Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Backgrounds And Aim: The association between trajectories of body-shape from early childhood to early adulthood (first 40 years of life) and subsequent depression risk has not been explored before. We assessed this association in a prospective cohort of university graduates.

Methods: We used a group-based modeling approach to assess the body shape trajectories from age 5 to 40 years, among 3888 women and 4124 men of the "Seguimiento Universidad de Navarra" (SUN) cohort study. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.055DOI Listing

SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic-smoking interaction analysis.

Mol Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Smoking cessation prolongs survival and decreases mortality of patients with non-small-cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions between smoking cessation and epigenetics have not been assessed. Read More

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http://dx.doi.org/10.1002/1878-0261.12482DOI Listing
March 2019
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Oral Health in Relation to Pancreatic Cancer Risk in African American Women.

Cancer Epidemiol Biomarkers Prev 2019 Apr 28;28(4):675-679. Epub 2019 Mar 28.

Slone Epidemiology Center at Boston University, Boston, Massachusetts.

Background: Incidence of pancreatic cancer is higher in African Americans than in U.S. whites. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449192PMC

miRNAs expression of oral squamous cell carcinoma patients: Validation of two putative biomarkers.

Medicine (Baltimore) 2019 Mar;98(13):e14922

Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Santiago de Compostela University, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela.

microRNA expression patterns have provided new directions in the search of biomarkers with prognostic value and even in the search of novel therapeutic targets for several neoplasms. Specifically, miRNAs profiling in oral squamous cell carcinoma (OSCC) represents a web of intrigue in the study of oral carcinogenesis. The objective of the present study was twofold:The first study phase comprised case-control groups: A) 8 OSCC-affected patients and 8 healthy controls. Read More

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http://dx.doi.org/10.1097/MD.0000000000014922DOI Listing

Application of blood concentration biomarkers in nutritional epidemiology: example of carotenoid and tocopherol intake in relation to chronic disease risk.

Am J Clin Nutr 2019 Apr;109(4):1189-1196

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Background: Biomarkers provide potential to objectively measure the intake of nutrients and foods, and thereby to strengthen nutritional epidemiology association studies. However, there are only a few established intake biomarkers, mostly based on recovery of nutrients or their metabolites in urine. Blood concentration measures provide a potential biomarker source for many additional nutritional variables, but their use in disease-association studies requires further development. Read More

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http://dx.doi.org/10.1093/ajcn/nqy360DOI Listing

Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma.

Sci Rep 2019 Mar 26;9(1):5179. Epub 2019 Mar 26.

Department of Cellular Biology and Immunology, Severo Ochoa Molecular Biology Center (CBMSO), CSIC-Madrid Autonomous University, Madrid, 28049, Spain.

Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence in T-cell lymphoblastic lymphoma needs to be determined yet. Using RNA-Seq we have selected 55 fusion transcripts identified by at least two of three detection methods in the same tumour. We confirmed the existence of 24 predicted novel fusions that had not been described in cancer or normal tissues yet, indicating the accuracy of the prediction. Read More

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http://www.nature.com/articles/s41598-019-41675-3
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http://dx.doi.org/10.1038/s41598-019-41675-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435891PMC
March 2019
3 Reads