18,057 results match your criteria Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Preventive Oncology[Journal]


Involuntary smoking and the risk of head and neck cancer in an East Asian population.

Cancer Epidemiol 2019 Feb 19;59:173-177. Epub 2019 Feb 19.

Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, United States.

Background: Although tobacco involuntary smoking is an established risk factor for lung cancer, the association with head and neck cancer (HNC) is not established. We aimed to investigate this potential association in an East Asian population.

Methods: We conducted a multicenter case-control study in East Asia including eight centers. Read More

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http://dx.doi.org/10.1016/j.canep.2019.01.020DOI Listing
February 2019

The prognostic relevance of urokinase-type plasminogen activator (uPA) in the blood of patients with metastatic breast cancer.

Sci Rep 2019 Feb 19;9(1):2318. Epub 2019 Feb 19.

Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

In breast cancer (BC), elevated levels of urokinase-type plasminogen activator (uPA) in tumor tissue have been confirmed as a strong prognostic factor in level-of-evidence-1 studies. The aim of the present study was to evaluate the clinical relevance of uPA levels in serum of metastatic BC patients and to compare uPA with other blood-based biomarkers. 252 patients were enrolled in this prospective, multicentre study. Read More

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http://dx.doi.org/10.1038/s41598-018-37259-2DOI Listing
February 2019

Nutritional Epidemiology Methods and Related Statistical Challenges and Opportunities.

Stat Theory Relat Fields 2018 17;2(1):2-10. Epub 2018 May 17.

Fred Hutchinson Cancer Research Center and University of Washington.

The public health importance of nutritional epidemiology research is discussed, along with methodologic challenges to obtaining reliable information on dietary approaches to chronic disease prevention. Measurement issues in assessing dietary intake need to be addressed to obtain reliable disease association information. Selfreported dietary data typically incorporate major random and systematic biases. Read More

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http://dx.doi.org/10.1080/24754269.2018.1466098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377194PMC

Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S140-S145

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The aim of this study was to investigate the expression of GKN1 and GKN2 genes as probable biomarkers for gastric cancer.

Background: Gastric cancer is a multifactorial process characterized by the uncontrolled growth and dissemination of abnormal cells. Survival rates of gastric cancer tend to be poor, a plausible explanation is a combination of a late-stage diagnosis and limited access to treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347995PMC
January 2018

Is there etiologic heterogeneity between subtypes of childhood acute lymphoblastic leukemia? A review of variation in risk by subtype.

Cancer Epidemiol Biomarkers Prev 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Division of Epidemiology and Clinical Research, University of Minnesota

While substantial advances in the identification of cytogenomic subtypes of childhood acute lymphoblastic leukemia (ALL) have been made in recent decades, epidemiologic research characterizing the etiologic heterogeneity of ALL by subtype has not kept pace. The purpose of this review is to summarize the current literature concerning subtype-specific epidemiologic risk factor associations with ALL subtype defined by immunophenotype (e.g. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0801DOI Listing
February 2019

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases.

Metabolites 2019 Feb 14;9(2). Epub 2019 Feb 14.

Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Perth 6150, Australia.

Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases. Read More

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http://dx.doi.org/10.3390/metabo9020034DOI Listing
February 2019

Pediatric Cardio-Oncology: Epidemiology, Screening, Prevention, and Treatment.

Cardiovasc Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

With five-year survival of children with cancer exceeding 80% in developed countries, premature cardiovascular disease is now a major cause of early morbidity and mortality. In addition to the acute and chronic cardiotoxic effects of anthracyclines, related chemotherapeutics, and radiation, a growing number of new molecular targeted agents may also have detrimental effects on the cardiovascular system. Survivors of childhood cancer also may have earlier development of conventional cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes, which further increase their risk of serious cardiovascular disease. Read More

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http://dx.doi.org/10.1093/cvr/cvz031DOI Listing
February 2019

Racial/Ethnic Differences in 25-Hydroxy Vitamin D and Parathyroid Hormone Levels and Cardiovascular Disease Risk Among Postmenopausal Women.

J Am Heart Assoc 2019 Feb;8(4):e011021

1 Department of Epidemiology Indiana University Richard M. Fairbanks School of Public Health Indianapolis IN.

Background Recent evidence suggests that racial/ethnic differences in circulating levels of free or bioavailable 25-hydroxy vitamin D (25[ OH ]D) rather than total 25( OH )D may explain apparent racial disparities in cardiovascular disease ( CVD ). We prospectively examined black-white differences in the associations of total, free, and bioavailable 25( OH )D, vitamin D-binding protein, and parathyroid hormone levels at baseline with incident CVD (including nonfatal myocardial infarction, nonfatal stroke, and CVD death) in postmenopausal women. Methods and Results We conducted a case-cohort study among 79 705 postmenopausal women, aged 50 to 79 years, who were free of CVD at baseline in the WHI-OS (Women's Health Initiative Observational Study). Read More

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http://dx.doi.org/10.1161/JAHA.118.011021DOI Listing
February 2019

Body shape trajectories and the incidence of hypertension in a Mediterranean cohort: The sun study.

Nutr Metab Cardiovasc Dis 2018 Dec 21. Epub 2018 Dec 21.

University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine-Clínica Universidad de Navarra, Pamplona, Spain; Centro de Investigacion Biomedica en Red Area de Fisiologia de la Obesidad y la Nutricion (CIBEROBN), Madrid, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Aims: Our aim was to assess the association between trajectories of body-shape across the first 40 years of life and subsequent development of hypertension in a Mediterranean cohort.

Methods And Results: We used a group-based modeling approach to assess body shape trajectories from age 5 to 40 years, among 7514 participants included in the SUN study (1999-2016), and assessed the subsequent incidence of hypertension. To create the trajectories, we used a censored normal model as a polynomial function of age. Read More

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http://dx.doi.org/10.1016/j.numecd.2018.12.004DOI Listing
December 2018

Biomarkers of Exposure Among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

Cancer Epidemiol Biomarkers Prev 2019 Feb 7. Epub 2019 Feb 7.

Center for Tobacco Products, Food and Drug Administration, DHHS.

Background: Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups.

Methods: Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never users of tobacco. We calculated geometric mean ratios (GMR) comparing groups with never users adjusting for sex, age, race/ethnicity, education and creatinine. Read More

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0539DOI Listing
February 2019
3 Reads
4.125 Impact Factor

ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population.

Medicine (Baltimore) 2019 Feb;98(6):e14297

Department of Gynecologic Oncology, Tianjin Central Hospital of Gynecology Obstetrics, Nankai University Affiliated Hospital.

Objective: DNA methylation markers have been assessed as potential biomarkers for early cervical cancer detection. Herein, we evaluated the diagnostic performance of zinc finger protein 582 (ZNF582) methylation for cervical cancer detection.

Methods: Eligible studies were systematically searched from the electronic databases. Read More

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http://dx.doi.org/10.1097/MD.0000000000014297DOI Listing
February 2019

Identification of Serum MicroRNAs as Novel Biomarkers in Esophageal Squamous Cell Carcinoma Using Feature Selection Algorithms.

Front Oncol 2018 21;8:674. Epub 2019 Jan 21.

Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.

Circulating microRNAs (miRNAs) are promising molecular biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC). We investigated the serum miRNA expression profiles from microarray-based technologies and evaluated the diagnostic value of serum miRNAs as potential biomarkers for ESCC by using feature selection algorithms. Serum miRNA expression profiles were obtained from 52 ESCC patients and 52 age- and sex-matched controls via performing a high-throughput microarray assay. Read More

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http://dx.doi.org/10.3389/fonc.2018.00674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348251PMC
January 2019

Epidemiology of Diet and Melanoma-Letter.

Cancer Epidemiol Biomarkers Prev 2019 Feb;28(2):420

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367703PMC
February 2019

Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.

Int J Cancer 2019 Feb 4. Epub 2019 Feb 4.

State Key Laboratory of Genetic Engineering, Zhongshan Hospital, Fudan University, and School of Life Sciences, Fudan University, Shanghai, 200438, China.

Glioma is the most common malignant primary brain tumors with poor prognosis. Genome wide association studies (GWAS) of glioma in populations with Western European ancestry were completed in the US and UK. However, our previous results strongly suggest the genetic heterogeneity could be important in glioma risk. Read More

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http://dx.doi.org/10.1002/ijc.32179DOI Listing
February 2019
1 Read
5.085 Impact Factor

Modulating the microbiome to improve therapeutic response in cancer.

Lancet Oncol 2019 Feb;20(2):e77-e91

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Although novel therapies, including immunotherapy, have dramatically improved outcomes for many patients with cancer, overall outcomes are heterogeneous and existing biomarkers do not reliably predict response. To date, predictors of response to cancer therapy have largely focused on tumour-intrinsic features; however, there is growing evidence that other host factors (eg, host genomics and the microbiome) can substantially affect therapeutic response. The microbiome, which refers to microbiota within a host and their collective genomes, is becoming increasingly recognised for its influence on host immunity, as well as therapeutic responses to cancer treatment. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30952-5DOI Listing
February 2019

A two-gene methylation signature for the diagnosis of bladder cancer in urine.

Epigenomics 2019 Feb 1;11(3):337-347. Epub 2019 Feb 1.

Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Aim: To analyze the potential of 14 cancer-associated genes, including six miRNAs, for bladder cancer (BC) diagnosis in urine.

Patients & Methods: DNA methylation levels of 14 genes were analyzed in urine of 72 BC patients and 75 healthy controls using quantitative methylation-specific PCR. Multivariate logistic regression analysis was used to determine an optimal marker panel. Read More

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https://www.futuremedicine.com/doi/10.2217/epi-2018-0094
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http://dx.doi.org/10.2217/epi-2018-0094DOI Listing
February 2019
2 Reads

Whole Genome Messenger RNA Profiling Identifies a Novel Signature to Predict Gastric Cancer Survival.

Clin Transl Gastroenterol 2019 Jan;10(1):e00004

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China.

Objectives: Molecular prognostic biomarkers for gastric cancer (GC) are still limited. We aimed to identify potential messenger RNAs (mRNAs) associated with GC prognosis and further establish an mRNA signature to predict the survival of GC based on the publicly accessible databases.

Methods: Discovery of potential mRNAs associated with GC survival was undertaken for 441 patients with GC based on the Cancer Genome Atlas (TCGA), with information on clinical characteristics and vital status. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000004DOI Listing
January 2019

Green tea extract for prevention of prostate cancer progression in patients on active surveillance.

Oncotarget 2018 Dec 28;9(102):37798-37806. Epub 2018 Dec 28.

H. Lee Moffitt Cancer Center & Research Institute, GU Oncology MMG, Tampa, FL 33612-9497, USA.

Background: Active surveillance (AS) has evolved as a management strategy for men with low grade prostate cancer (PCa). However, these patients report anxiety, doubts about the possible progression of the disease as well as higher decisional conflict regarding selection of active surveillance, and have been reported to ultimately opt for treatment without any major change in tumor characteristics. Currently, there is a paucity of research that systematically examines alternate strategies for this target population. Read More

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http://dx.doi.org/10.18632/oncotarget.26519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340872PMC
December 2018
1 Read

Clinical and prognostic significance of circulating levels of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma.

Oncotarget 2018 Dec 28;9(102):37721-37732. Epub 2018 Dec 28.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play critical roles in angiogenesis in hepatocellular carcinoma (HCC). In addition, recent data suggest that Ang-1/Ang-2 are involved in regulating the immune response. The aim of our study was to explore the clinical prognostic significance of plasma Ang-1 and Ang-2 in HCC. Read More

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http://dx.doi.org/10.18632/oncotarget.26507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340869PMC
December 2018

Perceived Cancer-related Risk and Beliefs in Texas: Findings from a 2018 Population-Level Survey.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Biostatistics, Unit 1411, The University of Texas MD Anderson Cancer Center

Background: Cancer beliefs and perceptions of cancer risk affect the cancer continuum.

Methods: We developed a cancer-focused questionnaire and administered it online to a nonprobability sample of the Texas population. Weighted multivariable logistic regression analysis identified key factors associated with perceptions and beliefs about cancer. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0846DOI Listing
January 2019

MicroRNA dysregulation and non-muscle invasive bladder cancer prognosis.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Dartmouth-Hitchcock Medical Center.

Background: The high rate of non-muscle invasive bladder cancer recurrence is a major challenge in patient management. microRNAs (miRNAs) functionally regulate tumor cell proliferation and invasion, and have strong potential as biomarkers, since they are robust to degradation. The objective of this project was to identify reproducible prognostic miRNAs in resected non-muscle invasive bladder tumor tissue that are predictive of the recurrent tumor phenotype. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0884DOI Listing
January 2019

Elevated platelet count appears to be causally associated with increased risk of lung cancer: A Mendelian randomization analysis.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Environmental Health, Harvard School of Public Health.

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear.

Methods: We performed single and combined multiple instrumental variable Mendelian Randomization(MR) analysis by an inverse-weighted (IVW) method, in addition to a series of sensitivity analyses. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0356DOI Listing
January 2019
3 Reads
4.125 Impact Factor

Allergies and the subsequent risk of cancer among elderly adults in the United States.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans.

Methods: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data to perform a case-control study. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0887DOI Listing
January 2019
2 Reads

Plasma TNF-α and adiponectin levels differentiate psoriatic arthritis from psoriasis patients.

Br J Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI.

Psoriasis (PsO) and psoriatic arthritis (PsA) are inflammatory disorders. Circulating biomarkers of inflammation such as interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), and C-reactive protein (CRP) have been associated with disease severity and progression of PsO and PsA. Adiponectin and leptin are adipose derived cytokines, recognized as key regulator of body weight and metabolism . Read More

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http://dx.doi.org/10.1111/bjd.17700DOI Listing
January 2019
1 Read

One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.

Int J Cancer 2019 Jan 29. Epub 2019 Jan 29.

Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). Read More

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http://doi.wiley.com/10.1002/ijc.32165
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http://dx.doi.org/10.1002/ijc.32165DOI Listing
January 2019
3 Reads

A Pragmatic Testing-Eligibility Framework for Population Mutation Screening: The Example of .

Cancer Epidemiol Biomarkers Prev 2019 Feb 28;28(2):293-302. Epub 2019 Jan 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland.

Background: Eligibility guidelines for genetic testing may be revisited, given technological advances, plummeting costs, and proposals for population mutation screening. A key property of eligibility criteria is the tradeoff between the number of mutation carriers identified versus population members tested. We assess the fractions of mutation carriers identified, versus women undergoing mutation testing, for founder mutation screening in U. Read More

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0584DOI Listing
February 2019
2 Reads

Genome-wide analysis of expression quantitative trait loci identified potential lung cancer susceptibility variants among Asian populations.

Carcinogenesis 2019 Jan 23. Epub 2019 Jan 23.

Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Even though genome-wide association studies (GWASs) have identified dozens of single nucleotide polymorphisms (SNPs) affecting the susceptibility to lung cancer, only a tiny fraction of heritability can be explained. Regulating the expression of surrounding genes is one of the important mechanisms for SNPs to exert their effect. So it is necessary to systematically evaluate the associations between expression quantitative trait loci (eQTL) and lung cancer risk. Read More

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https://academic.oup.com/carcin/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/carcin/bgy165DOI Listing
January 2019
2 Reads

Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation.

Clin Transplant 2019 Jan 28:e13487. Epub 2019 Jan 28.

University of California, San Francisco, Kidney Transplant Service, CA, 94143-0780, United States.

Background: We investigated circulating levels of individual soluble urokinase plasminogen activation receptor (suPAR) forms to determine if specific circulating fragments of suPAR (II-III) and (I) can better serve as clinical biomarkers for FSGS and the risk of recurrence after transplantation.

Materials And Methods: Serum levels of intact suPAR and its cleaved forms were measured with 2 assays, ELISA and TR-FIA 2.

Results: suPAR levels in healthy controls were significantly lower than those who had glomerular diseases but were not significantly different between FSGS patients and glomerular controls. Read More

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http://dx.doi.org/10.1111/ctr.13487DOI Listing
January 2019
1 Read

Needs with Regard to Decision Support Systems for Treating Patients with Incurable Non-small Cell Lung Cancer.

J Cancer Educ 2019 Jan 26. Epub 2019 Jan 26.

Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, De Boelelaan 1089a, PO Box 7057, 1081 HV, Amsterdam, The Netherlands.

Treatment decision-making for patients with incurable non-small cell lung cancer (NSCLC) is complex due to the rapidly increasing number of treatments and discovery of new biomarkers. Decision support systems (DSS) could assist thoracic oncologists (TO) weighing of the pros and cons of treatments in order to arrive at an evidence-based and personalized treatment advice. Our aim is to inventory (1) TO's needs with regard to DSS in the treatment of incurable (stage IIIB/IV) NSCLC patients, and (2) preferences regarding the development of future tools in this field. Read More

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http://dx.doi.org/10.1007/s13187-019-1471-8DOI Listing
January 2019
9 Reads

Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer.

Clin Nutr 2019 Jan 15. Epub 2019 Jan 15.

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden; Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.

Background & Aims: Rye consumption has shown beneficial effects on prostate cancer tumors, as indicated by slower initial tumor growth in animal models and lowering of prostate-specific antigen (PSA) in humans. This study evaluated the effects of whole grain/bran rye consumption on low-grade inflammation and endothelial function biomarkers in men with prostate cancer.

Methods: Seventeen men with untreated, low-grade prostate cancer consumed 485 g rye whole grain and bran products (RP) per day or refined wheat products with added cellulose (WP) in a randomized crossover design. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.01.007DOI Listing
January 2019
4 Reads

Metastatic Immune Infiltrates Correlate with Those of the Primary Tumor in Canine Osteosarcoma.

Vet Comp Oncol 2019 Jan 25. Epub 2019 Jan 25.

The Comparative Oncology Laboratory and Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.

Our lack of understanding of the immune microenvironment in canine osteosarcoma (cOSA) has limited the identification of potential immunotherapeutic targets. In particular, our ability to utilize readily available tissue from a dog's primary tumor to predict the type and extent of immune response in their pulmonary metastatic lesions is unknown. We therefore collected 21 matched pairs of primary tumors and pulmonary metastatic lesions from dogs with OSA and performed immunohistochemistry to quantify T lymphocyte (CD3), FOXP3+ cell, B lymphocyte (Pax-5), and CD204+ macrophage infiltration. Read More

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http://dx.doi.org/10.1111/vco.12459DOI Listing
January 2019
5 Reads

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0. Read More

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019
5 Reads
10.742 Impact Factor

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier.

Breast Cancer Res 2019 Jan 25;21(1):14. Epub 2019 Jan 25.

Department of Epidemiology, Lebanon, USA.

Background: BRCA1-mutated cancers exhibit deficient homologous recombination (HR) DNA repair, resulting in extensive copy number alterations and genome instability. HR deficiency can also arise in tumors without a BRCA1 mutation. Compared with other breast tumors, HR-deficient, BRCA1-like tumors exhibit worse prognosis but selective chemotherapeutic sensitivity. Read More

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https://breast-cancer-research.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s13058-018-1090-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347811PMC
January 2019
3 Reads

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study.

PLoS Med 2019 Jan 24;16(1):e1002730. Epub 2019 Jan 24.

Department of Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Background: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers. In the present study, we investigated whether deep convolutional neural networks (CNNs) can extract prognosticators directly from these widely available images. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345440PMC
January 2019
1 Read

Beta Human Papillomavirus and Associated Diseases.

Acta Cytol 2019 Jan 23:1-9. Epub 2019 Jan 23.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

The cutaneous human papillomavirus (HPV), mostly from β- and γ-HPV genus, is ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of β-HPVs and cutaneous squamous cell carcinoma (cSCC) development was initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis. Likewise, immunosuppressed organ transplant recipients have an increased susceptibility to β-HPV infections in the skin as well as to cSCC development. Read More

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https://www.karger.com/Article/FullText/492659
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http://dx.doi.org/10.1159/000492659DOI Listing
January 2019
3 Reads

Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma.

World J Gastroenterol 2019 Jan;25(2):220-232

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

Background: Recent evidence shows that long non-coding RNAs (lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma (HCC). Increasing studies demonstrate that lncRNAs are potential prognostic factors for HCC. Moreover, several studies reported the combination of lncRNAs for predicting the overall survival (OS) of HCC, but the results varied. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i2/220.htm
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http://dx.doi.org/10.3748/wjg.v25.i2.220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337021PMC
January 2019
4 Reads

Current status, problems, and perspectives of non-alcoholic fatty liver disease research.

World J Gastroenterol 2019 Jan;25(2):163-177

Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

Non-alcoholic fatty liver disease (NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and ultimately death. NAFLD is pathologically classified as non-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH) based on the existence of ballooned hepatocytes, although the states have been known to transform into each other. Moreover, since the detection of ballooned hepatocytes may be difficult with limited biopsied specimens, its clinical significance needs reconsideration. Read More

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http://dx.doi.org/10.3748/wjg.v25.i2.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337019PMC
January 2019
1 Read

DNA methylation GrimAge strongly predicts lifespan and healthspan.

Aging (Albany NY) 2019 Jan;11(2):303-327

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators of plasma proteins including those of plasminogen activator inhibitor 1 (PAI-1) and growth differentiation factor 15. The resulting predictor of lifespan, DNAm GrimAge (in units of years), is a composite biomarker based on the seven DNAm surrogates and a DNAm-based estimator of smoking pack-years. Read More

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http://www.aging-us.com/article/101684/text
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http://dx.doi.org/10.18632/aging.101684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366976PMC
January 2019
11 Reads

EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC.

Epigenetics 2019 Jan 21:1-12. Epub 2019 Jan 21.

b Department of Environmental Health , Harvard T.H. Chan School of Public Health , Boston , MA , USA.

Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognosis of many cancers, few studies examined DNA methylation in EGLNs and its relationship to prognosis of early-stage non-small cell lung cancer (NSCLC). Read More

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https://www.tandfonline.com/doi/full/10.1080/15592294.2019.1
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http://dx.doi.org/10.1080/15592294.2019.1573066DOI Listing
January 2019
4 Reads

Plasma metabolites associated with colorectal cancer: A discovery-replication strategy.

Int J Cancer 2019 Jan 21. Epub 2019 Jan 21.

Huntsman Cancer Institute, Salt Lake City, UT.

Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics is becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal cancer is limited by sample size and did not replicate findings in independent study populations to verify robustness of reported findings. Read More

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http://dx.doi.org/10.1002/ijc.32146DOI Listing
January 2019
2 Reads

Detection of West Nile virus lineage 1 sequences in blood donors, Punjab province, Pakistan.

Int J Infect Dis 2019 Jan 18. Epub 2019 Jan 18.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Objectives: This study was performed to determine the presence of West Nile virus (WNV) in mosquito specimens and human blood donors from Pakistan.

Methods: 4,500 mosquito specimens were collected using CO-baited traps from five selected districts of Punjab province, Pakistan. Mosquito were taxonomically identified using standard morphological keys resulting in 166 pools. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.020DOI Listing
January 2019
5 Reads
2.330 Impact Factor

Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS).

Prostate Cancer Prostatic Dis 2019 Jan 21. Epub 2019 Jan 21.

Cancer Prevention Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: For men on active surveillance for prostate cancer, biomarkers may improve prediction of reclassification to higher grade or volume cancer. This study examined the association of urinary PCA3 and TMPRSS2:ERG (T2:ERG) with biopsy-based reclassification.

Methods: Urine was collected at baseline, 6, 12, and 24 months in the multi-institutional Canary Prostate Active Surveillance Study (PASS), and PCA3 and T2:ERG levels were quantitated. Read More

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http://www.nature.com/articles/s41391-018-0124-z
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http://dx.doi.org/10.1038/s41391-018-0124-zDOI Listing
January 2019
3 Reads

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single-arm trial.

J Hum Nutr Diet 2019 Jan 21. Epub 2019 Jan 21.

Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The influence of nutrition on breast cancer prognosis is still inconclusive and therefore dietary interventions incorporating dietary biomarkers are needed to confirm compliance with dietary goals and clarify biological mechanisms. The present study assessed whether a lifestyle intervention in breast cancer survivors could affect dietary biomarkers of fruit and vegetables and fatty acids.

Methods: In this phase II single-arm trial, 37 overweight/obese early stage breast cancer patients completed a 12-week diet and exercise intervention. Read More

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http://dx.doi.org/10.1111/jhn.12621DOI Listing
January 2019
1 Read

The diagnostic performance of current tumour markers in surveillance for recurrent testicular cancer: A diagnostic test accuracy systematic review.

Cancer Epidemiol 2019 Jan 15;59:15-21. Epub 2019 Jan 15.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK. Electronic address:

In this diagnostic test accuracy systematic review we summarise the evidence on the diagnostic accuracy of blood α-fetoprotein (AFP), human chorionic gonadotropin (HCG) and lactate dehydrogenase (LDH) in surveillance for testicular cancer recurrence in adults. We searched four electronic databases for studies that reported the diagnostic accuracy of HCG, AFP, and/or LDH in sufficient detail for sensitivity and specificity to be calculated by extracting a 2 × 2 table comparing biomarker positivity with testicular cancer recurrence. Screening, data extraction and QUADAS-2 quality assessment were completed by two independent reviewers. Read More

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http://dx.doi.org/10.1016/j.canep.2019.01.001DOI Listing
January 2019
1 Read

Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study.

J Hepatol 2019 Mar 15;70(3):521-530. Epub 2019 Jan 15.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address:

A joint meeting of the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) was held in London on September 30 and October 1, 2017. The goals of the meeting were to identify areas of broad agreement and disagreement, develop consensus, and determine future directions to ultimately reduce the burden, morbidity, and mortality of alcohol-related liver disease (previously termed alcoholic liver disease). The specific aims of the meeting were to identify unmet needs and areas for future investigation, in order to reduce alcohol consumption, develop markers for diagnosis and prognosis of disease, and create a framework to test novel pharmacological agents with pre-specified treatment endpoints. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.10.041DOI Listing

Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.

Circ Genom Precis Med 2019 Feb;12(2):e002413

Division of Cardiovascular Medicine (M.C., F.L., J.R., C.G., A.F., J.H., Z.M.), University of Cambridge, United Kingdom.

Background: The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor ( IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R-Asp358Ala variant and AAA growth and to assess the effect of blocking the IL-6 signaling pathway in mouse models of aortic aneurysm rupture or dissection.

Methods: Using data from 2863 participants with AAA from 9 prospective cohorts, age- and sex-adjusted mixed-effects linear regression models were used to estimate the association between the IL6R-Asp358Ala variant and annual change in AAA diameter (mm/y). Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002413DOI Listing
February 2019
8 Reads

Circulating miR-26a, miR-106b, miR-107 and miR-133b stratify hepatocellular carcinoma patients according to their response to transarterial chemoembolization.

Clin Biochem 2019 Jan 15. Epub 2019 Jan 15.

Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt. Electronic address:

Background: A number of hepatocellular carcinoma (HCC) patients have developed resistance against transcatheter arterial chemoembolization (TACE) treatment. In this study, we aimed to develop a panel of microRNAs (miRs) biomarkers to predict clinical outcomes in HCC patients after TACE treatment.

Methods: The expression level of twenty miRs was evaluated in FFPE tissues collected from 33 HCC patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00099120183091
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http://dx.doi.org/10.1016/j.clinbiochem.2019.01.002DOI Listing
January 2019
8 Reads

Circulating microRNAs are associated with early childhood obesity: results of the I.Family Study.

Genes Nutr 2019 9;14. Epub 2019 Jan 9.

1Institute of Food Sciences, National Research Council, ISA-CNR, Via Roma, 64 83100 Avellino, Italy.

Background: Nearly 10 years ago, the World Health Organization reported the increasing prevalence of overweight and obesity worldwide as a challenge for public health due to the associated adverse consequences. Epidemiological studies established a firm relationship between an elevated body mass index and chronic conditions such as diabetes, dyslipidemia, hypertension, heart disease, non-alcoholic fatty liver disease, and some types of cancer. Omic studies demonstrated that microRNA (miRNA) profile changes in tissues correlate with a number of diseases, including obesity. Read More

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https://genesandnutrition.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/s12263-018-0622-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327413PMC
January 2019
4 Reads

Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer.

J Natl Cancer Inst 2019 Jan 14. Epub 2019 Jan 14.

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Background: Constitutional loss of function (LOF) single nucleotide polymorphisms (SNPs) in pattern recognition receptors FPR1, TLR3, and TLR4 have previously been reported to predict oxaliplatin benefit in colorectal cancer. Confirmation of this association could substantially improve patient stratification.

Methods: We performed a retrospective biomarker analysis of the Short Course in Oncology Therapy (SCOT) and COIN/COIN-B trials. Read More

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http://dx.doi.org/10.1093/jnci/djy215DOI Listing
January 2019
1 Read

Shift Work and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study.

J Occup Environ Med 2019 Jan 9. Epub 2019 Jan 9.

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA (Meghan M. Holst, Michael D. Wirth, James B. Burch); Cancer Prevention and Control Program, University of South Carolina, Columbia, SC USA (Michael D. Wirth, James B. Burch); College of Nursing, University of South Carolina, Columbia, SC, USA (Michael D. Wirth); Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA (Anna Mnatsakanova, Luenda E. Charles, Cathy Tinney-Zara, Desta Fekedulegn, Michael E. Andrew, Tara A. Hartley); WJB Dorn VA Medical Center, Columbia, SC, USA (James B. Burch); Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University of Buffalo, The State University of New York, Buffalo, NY, USA (John M. Violanti).

Objective: To assess the association of shift work with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort METHODS:: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.

Results: Associations were observed between day and night shift workers for leukocytes, tumor necrosis factor alpha and homocysteine. Read More

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http://Insights.ovid.com/crossref?an=00043764-900000000-9849
Publisher Site
http://dx.doi.org/10.1097/JOM.0000000000001541DOI Listing
January 2019
10 Reads