4,118,082 results match your criteria Cancer drug resistance Alhambra Calif.[Journal]


Impact of extent of disease on 1-year healthcare costs in patients who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: retrospective observational cohort study.

BJS Open 2020 Jul 11. Epub 2020 Jul 11.

Departments of Surgery, Division of Surgical Oncology, Groningen, the Netherlands.

Background: The goal of this retrospective observational study was to determine the impact of the extent of peritoneal disease on 1-year healthcare costs in patients with colorectal peritoneal metastases (PM) who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). The extent of peritoneal disease, expressed by the Peritoneal Cancer Index (PCI), directly affects the complexity of CRS + HIPEC and ultimately survival outcomes. The impact of the PCI on treatment-related healthcare costs remains unknown. Read More

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http://dx.doi.org/10.1002/bjs5.50320DOI Listing

Mandibular undifferentiated pleomorphic sarcoma: Molecular analysis of a primary cell population.

Clin Exp Dent Res 2020 Jul 11. Epub 2020 Jul 11.

Oral and Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Undifferentiated pleomorphic sarcomas are one of the most common subtypes of soft tissue sarcomas. These are aggressive mesenchymal tumors and are devoid of the major known biomarkers except vimentin. Our objective was to establish and characterize a primary cell population from a mandibular UPS specimen. Read More

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http://dx.doi.org/10.1002/cre2.301DOI Listing

Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature.

Mol Genet Genomic Med 2020 Jul 11:e1396. Epub 2020 Jul 11.

Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: Minichromosome maintenance complex component 8 (MCM8) is responsible for homologous recombination and DNA double-strand breaks (DSBs) repair and is the cause of primary ovarian insufficiency (POI), which is seldom diagnosed in adolescents and children.

Methods: Whole-exome sequencing was performed in a 13-year-old girl, and Sanger sequencing was used to identify potentially pathogenic variants in her sister (aged 6 years and 7 months) and parents. To identify potential pathogenic mutations, DSBs were induced by mitomycin C (MMC), and the DNA repair capacity was evaluated by the histone H2AX phosphorylation level. Read More

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http://dx.doi.org/10.1002/mgg3.1396DOI Listing

Enzyme Instructed Self-assembly of Naphthalimide-dipeptide: Spontaneous Transformation from Nanosphere to Nanotubular Structures that Induces Hydrogelation.

Chem Asian J 2020 Jul 11. Epub 2020 Jul 11.

National Chiao Tung University, Materials Science and Engineering, 1001 University Rd., 30010, Hsinchu, TAIWAN.

Understanding the structure-morphology relationships of the self-assembled nanostructures is very crucial for developing the materials with the desired chemical and biological functions. Here, phosphate-based naphthalimide (NI) derivatives have been developed for the first time to study the enzyme instructed self-assembly process. Self-assembly of simple amino acid derivative NI-Y p resulted in non-specific amorphous aggregates in the presence of alkaline phosphatase enzyme. Read More

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http://dx.doi.org/10.1002/asia.202000575DOI Listing

LINC00160 mediated paclitaxel-And doxorubicin-resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ.

J Cell Mol Med 2020 Jul 11. Epub 2020 Jul 11.

Center for Precision Medicine, Anhui No.2 Provincial People's Hospital, Hefei, China.

Chemoresistance represents a major challenge in breast cancer (BC) treatment. This study aimed to probe the roles of LINC00160 in paclitaxel- and doxorubicin-resistant BC cells. Three pairs of BC and adjacent normal tissue were used for lncRNA microarray analysis. Read More

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http://dx.doi.org/10.1111/jcmm.15487DOI Listing

Knockdown of DNA binding protein A (dbpA) enhances the chemotherapy sensitivity of colorectal cancer via suppressing the Wnt/β-catenin/Chk1 pathway.

Cell Biol Int 2020 Jul 11. Epub 2020 Jul 11.

Department of hepatobiliary surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, P.R. China.

DNA-binding protein A (dbpA) is reported to be upregulated in many cancers and associated with tumor progress. The present study aimed to investigate the role of dbpA in 5-Fluorouracil (5-FU)-resistant and Oxaliplatin (L-OHP)-resistant colorectal cancer (CRC) cells. We found that 5-FU and L-OPH treatment promoted the expression of dbpA. Read More

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http://dx.doi.org/10.1002/cbin.11416DOI Listing

The impact of antibiotic allergy testing in transplant patients.

Transpl Infect Dis 2020 Jul 11:e13411. Epub 2020 Jul 11.

Department of Infectious Diseases and Centre for Antibiotic Allergy and Research, Austin Health,, VIC, Australia.

Patient reported antibiotic allergies, so-called antibiotic allergy labels (AAL) are highly prevalent amongst hospitalized patients globally . The highest prevalence of AALs has been found to be in immunocompromised patients, in particular transplant patients, with a large U.S. Read More

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http://dx.doi.org/10.1111/tid.13411DOI Listing

Interventional low-dose azithromycin attenuates cigarette smoke-induced emphysema and lung inflammation in mice.

Physiol Rep 2020 Jul;8(13):e14419

Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Cigarette smoke (CS)-induced emphysema is an important contributor to chronic obstructive pulmonary disease (COPD). We have shown the efficacy of azithromycin in reducing airway inflammation in COPD and in reducing exacerbations in severe asthma; however, the effects of long-term azithromycin on emphysema development have not been shown. We employed live animal imaging to monitor emphysema-like development and the effects of interventional azithromycin treatment in CS-exposed mice. Read More

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http://dx.doi.org/10.14814/phy2.14419DOI Listing

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX Interaction.

Mol Oncol 2020 Jul 11. Epub 2020 Jul 11.

Departments of Pharmacology & Toxicology, School of Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.

Tumor cells undergo senescence in response to both conventional and targeted cancer therapy. The induction of senescence in response to cancer therapy can contribute to unfavorable outcomes, potentially including cancer relapse. This work demonstrates that tumor cells induced into senescence by doxorubicin, etoposide, or radiation can give rise to viable tumors in vivo. Read More

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http://dx.doi.org/10.1002/1878-0261.12761DOI Listing

Management of breast cancer risk in BRCA1/2 mutation carriers who are unaffected with cancer.

Breast J 2020 Jul 11. Epub 2020 Jul 11.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA.

Pathogenic mutations in BRCA1 and BRCA2 genes markedly increase the risk of breast cancer and other cancers such as ovarian/fallopian tube, pancreatic, prostate, and melanoma. Patients with BRCA1 mutations have a slightly higher lifetime risk of breast cancer than BRCA2 mutation carriers, and both BRCA1 and BRCA2 carriers tend to develop breast cancer at an earlier age than the general population. In this review, we will discuss management recommendations to reduce breast cancer risk for BRCA1/2 mutation carriers including special populations of carriers such as pregnant or lactating patients and men. Read More

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http://dx.doi.org/10.1111/tbj.13970DOI Listing

Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study.

J Hepatobiliary Pancreat Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Pancreatobiliary Cancer Clinic, Gangnam Severance Hospital, Yonsei University College of Medicine, Korea.

Introduction: Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. Read More

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http://dx.doi.org/10.1002/jhbp.801DOI Listing

Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea.

Physiol Rep 2020 Jul;8(13):e14490

Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFr TKIs) are first-line therapies for various cancers, and cause dose-limiting severe diarrhea in many patients. We hypothesized that diarrhea caused by EGFr TKIs might reflect actions on epithelial transport, barrier function, or both, which we tested using cell cultures including murine and human enteroid-derived monolayers (EDMs), analyzed using electrophysiological and other relevant methods. EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically. Read More

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http://dx.doi.org/10.14814/phy2.14490DOI Listing

Increased Inflammasome Activity in Subcutaneous Adipose Tissue of Patients with Metabolic Syndrome.

Diabetes Metab Res Rev 2020 Jul 11. Epub 2020 Jul 11.

VA Medical Center, Mather, California.

Aims: The metabolic syndrome (MetS) is an inflammatory disorder associated with an increased risk for diabetes and atherosclerotic cardiovascular disease (ASCVD). Studies in patients and animal models of obesity and diabetes have shown increased NOD-like receptor family pyrin domain containing 3 (NLPR3) inflammasome activity. However, there is scanty data on the activity of the NLRP3 inflammasome in patients with nascent MetS. Read More

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http://dx.doi.org/10.1002/dmrr.3383DOI Listing

High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent and nutrition intervention remains the most important therapeutic approach for NAFLD. Our aim was to investigate whether low- (LP) or high-protein (HP) diets are more effective in reducing liver fat and reversing NAFLD and which mechanisms are involved.

Methods: 19 participants with morbid obesity undergoing bariatric surgery were randomized into two hypocaloric (1500-1600 kcal/day) diet groups, a low protein (10E% protein) and a high protein (30E% protein), for three weeks prior to surgery. Read More

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http://dx.doi.org/10.1111/liv.14596DOI Listing

Shift work and incidence of dementia: A Danish Nurse Cohort study.

Alzheimers Dement 2020 Jul 11. Epub 2020 Jul 11.

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses.

Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Read More

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http://dx.doi.org/10.1002/alz.12126DOI Listing

GEICAM Guidelines for the Management of Patients with Breast Cancer During Spain's COVID-19 Pandemic.

Oncologist 2020 Jul 11. Epub 2020 Jul 11.

Medical Oncology, Instituto de Investigación Sanitaria Gregorio Marañón, Departamento de Medicina, Universidad Complutense, Madrid, Spain.

Breast cancer (BC) is the most common cancer in women in Spain. During the COVID-19 pandemic caused by the SARS-Cov-2 virus, patients with BC require timely treatment and follow-up. However, not only are hospitals overwhelmed with infected patients, some patients with BC are at higher risk for infection and for serious complications if infected. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0363DOI Listing

The value of preoperative high-resolution MRI with microscopy coil for facial nonmelanoma skin cancers.

Skin Res Technol 2020 Jul 11. Epub 2020 Jul 11.

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R.China.

Background: The extent and depth of facial nonmelanoma skin cancers and the involvement of adjacent structures are critical features for surgical planning, but they are difficult to assess clinically. High-resolution MRI (HR-MRI) with microscopy coil may facilitate detailed evaluation of skin lesions. The authors performed this prospective study to determine the value of high-resolution microscopy coil MRI in the preoperative evaluation of nonmelanoma skin cancer. Read More

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http://dx.doi.org/10.1111/srt.12909DOI Listing

Diabetes mellitus in major head and neck cancer surgery: Systematic review and meta-analysis.

Head Neck 2020 Jul 11. Epub 2020 Jul 11.

Department of Otolaryngology-Head & Neck Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.

Background: Diabetes mellitus (DM) is a risk factor for surgical complications and a common comorbidity in the setting of head and neck (H&N) cancer. Our objective was to determine if DM is associated with increased rates of H&N cancer surgery complications.

Methods: We conducted a search of Pubmed, Embase, and the national clinical trials database focusing on H&N cancer surgery or free flap reconstruction and diabetes. Read More

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http://dx.doi.org/10.1002/hed.26349DOI Listing

Low protein intake during reproduction compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Institute of Life Course and Medical Sciences, The MRC - Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.

Lactation-induced bone loss occurs due to high calcium requirements for fetal growth but skeletal recovery is normally achieved promptly postweaning. Dietary protein is vital for fetus and mother but the effects of protein undernutrition on the maternal skeleton and skeletal muscles are largely unknown. We used mouse dams fed with normal (N, 20%) or low (L, 8%) protein diet during gestation and lactation and maintained on the same diets (NN, LL) or switched from low to normal (LN) during a 28 d skeletal restoration period post lactation. Read More

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http://dx.doi.org/10.1096/fj.202001131RDOI Listing

MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Department of Medical Genetics, Center for Medical Genetics, Peking University Health Science Center, Beijing, China.

Werner syndrome protein (WRN) plays critical roles in DNA replication, recombination, and repair, as well as transcription and cellular senescence. Ubiquitination and degradation of WRN have been reported, however, the E3 ubiquitin ligase of WRN is little known. Here, we identify mindbomb E3 ubiquitin protein ligase 1 (MIB1) as a novel E3 ubiquitin ligase for WRN protein. Read More

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http://dx.doi.org/10.1096/fj.202000268RRRDOI Listing

Nuclear β-catenin immunoexpression in scars.

J Cutan Pathol 2020 Jul 11. Epub 2020 Jul 11.

Department of Diagnostic Pathology, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.

Background: Histopathologically, scars can mimic superficial fibromatoses. Superficial fibromatoses are known to show nuclear β-catenin immunoexpression, although the tumor types do not harbor CTNNB1 or APC alterations. The present study aimed to evaluate nuclear β-catenin immunoexpression in scars compared to that in superficial fibromatoses. Read More

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http://dx.doi.org/10.1111/cup.13806DOI Listing

Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer with GOPC-ROS1 Fusion Using Crizotinib: A Case Report.

Oncologist 2020 Jul 11. Epub 2020 Jul 11.

Geneplus-Beijing Ltd., Beijing, People's Republic of China.

Background: Recently, multiple poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated excellent efficacy among patients with ovarian cancer with or without BRCA mutations. However, alternative therapeutic options are urgently required for patients who cannot benefit from conventional chemotherapy or PARP inhibitors.

Case Presentation: A patient with high-grade serous ovarian carcinoma presented to our clinic after developing resistance to chemotherapy. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0609DOI Listing

Salivary side effects after radioiodine treatment for differentiated papillary thyroid carcinoma: Long-term study.

Head Neck 2020 Jul 11. Epub 2020 Jul 11.

Department of Maxillofacial Surgery and Stomatology of Pr Chossegros, APHM, CHU Conception, Marseille, France.

Background: Although many studies focus on short-term side effects of radioiodine therapy, almost none studied long-term side effects. We assessed radioiodine long-term salivary side effects after radioiodine treatment for differentiated papillary thyroid carcinoma and compared it to short-term morbidity within the same population.

Methods: A standardized self-administrated questionnaire was submitted in 2019 by patients treated with radioiodine between January 2011 and December 2012. Read More

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http://dx.doi.org/10.1002/hed.26359DOI Listing

Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors.

Pediatr Blood Cancer 2020 Jul 11:e28538. Epub 2020 Jul 11.

San Vito al Tagliamento, Pordenone, Scientific Institute Eugenio Medea, Italy.

Background: Cerebellar tumor survivors often exhibit neuropsychological deficits that could be related to alterations in cerebro-cerebellar networks. This is a pilot study designed to understand if diffusion tensor imaging (DTI)-based tractography is able to identify possible correlations between cerebellar white matter structure and cognitive outcome in children on long-term follow-up for posterior fossa (PF) tumors who were thoroughly assessed for neuropsychological functioning.

Methods: DTI-based tractography was performed in pediatric patients with PF tumors. Read More

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http://dx.doi.org/10.1002/pbc.28538DOI Listing

DNMT3B deficiency alters mitochondrial biogenesis and α-ketoglutarate levels in human embryonic stem cells.

Stem Cells 2020 Jul 11. Epub 2020 Jul 11.

Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.

Embryonic stem cell (ESC) renewal and differentiation is regulated by metabolites that serve as co-factors for epigenetic enzymes. Increase of α-ketoglutarate (α-KG), a co-factor for histone and DNA demethylases, triggers multi-lineage differentiation in human ESCs. To gain further insight how the metabolic fluxes in pluripotent stem cells can be influenced by inactivating mutations in epigenetic enzymes, we generated human ESCs deficient for de novo DNA methyltransferases (DNMT) 3A and 3B. Read More

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http://dx.doi.org/10.1002/stem.3256DOI Listing

Long-term effectiveness of lycopene in the management of oral submucous fibrosis (OSMF): A 3 year follow-up study.

J Oral Pathol Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: Long-term follow-ups after receiving lycopene therapy for management of Oral Submucous Fibrosis (OSMF) are scarce. The study aimed to assess the long-term efficacy of lycopene for management of OSMF symptoms.

Methods: In this prospective clinical study, 400 clinically diagnosed early OSMF patients were assessed for the efficacy of lycopene in alleviation of burning sensation (BS) and reduced mouth opening (MO) symptoms in comparison to placebo. Read More

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http://dx.doi.org/10.1111/jop.13085DOI Listing

Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

Defects in the motor domain of kinesin family member 1A (KIF1A), a neuron-specific ATP-dependent anterograde axonal transporter of synaptic cargo, are well-recognized to cause a spectrum of neurological conditions, commonly known as KIF1A-associated neurological disorders (KAND). Here we report one mutation-negative female with classic Rett syndrome (RTT) harboring a de novo heterozygous novel variant [NP_001230937.1:p. Read More

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http://dx.doi.org/10.1002/humu.24079DOI Listing

Impridone enhances vascular relaxation via FOXO1 pathway.

Clin Exp Pharmacol Physiol 2020 Jul 11. Epub 2020 Jul 11.

Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia.

Cardiovascular complications are a side effect of cancer therapy, potentially through reduced blood vessel function. ONC201(TIC10) is currently used in Phase 2 clinical trials to treat high-grade gliomas. TIC10 is a Phosphatidylinositol 3-kinase (PI3K)/AKT/extracellular signal-regulated kinase (ERK) inhibitor that induces apoptosis via upregulation of TNF-related apoptosis-inducing ligand, which via stimulation of FOXO and death receptor could increase eNOS upregulation. Read More

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http://dx.doi.org/10.1111/1440-1681.13377DOI Listing

A quick UPLC-MS/MS method for therapeutic drug monitoring of abiraterone and delta(4)-abiraterone (D4A) in human plasma.

Biomed Chromatogr 2020 Jul 11:e4947. Epub 2020 Jul 11.

Graduate program on Toxicology and Analytical Toxicology, Institute of Health Sciences, University Feevale, Novo Hamburgo, Brazil.

Abiraterone acetate efficacy against prostate cancer is dependent on the circulating levels of abiraterone and its active metabolites, which present significant pharmacokinetic variability among patients. Thus, therapeutic drug monitoring can be performed to improve treatment outcomes. To support such studies, there is only a limited number of bioanalytical methods in current literature. Read More

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http://dx.doi.org/10.1002/bmc.4947DOI Listing

Epithelial/mesenchymal heterogeneity of high-grade serous ovarian carcinoma samples correlates with miRNA let-7 levels and predicts tumor growth and metastasis.

Mol Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Basic Sciences, Division of Biochemistry, Loma Linda University, Loma Linda, CA, USA.

Patient-derived samples present an advantage over current cell line models of high grade serous ovarian cancer (HGSOC) that are not always reliable and phenotypically faithful models of in vivo HGSOC. To improve upon cell line models of HGSOC, we set out to characterize a panel of patient-derived cells and determine their epithelial and mesenchymal characteristics. We analyzed RNA and protein expression levels in patient-derived xenograft (PDX) models of HGSOC, and functionally characterized these models using flow cytometry, wound healing assays, invasion assays and spheroid cultures. Read More

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http://dx.doi.org/10.1002/1878-0261.12762DOI Listing

Surgical management of mediastinal paraganglioma: All hands on deck!

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

The DeWitt Daughtry Department of Surgery, Division of Cardiothoracic Surgery, Thoracic Surgery Section, University of Miami, Miami, Florida.

Mediastinal paragangliomas are very uncommon neuroendocrine neoplasms. Due to their tissue of origin (sympathetic ganglia of the great vessels), they tend to arise deep within pericardial space and, more importantly, intimately attached to great vessels, which makes surgical resection, even with cardiopulmonary bypass, very challenging. This commentary accompanies the case report describing complex surgical management of a paraganglioma located in the anterior mediastinum that was initially thought to be a thymoma. Read More

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http://dx.doi.org/10.1111/jocs.14746DOI Listing

Long Term Follow Up of Hematopoietic Stem Cell Transplant Survivors: A Focus on Screening, Monitoring, and Therapeutics.

Pharmacotherapy 2020 Jul 11. Epub 2020 Jul 11.

University of California, San Francisco Medical Center, Department of Pharmaceutical Services, San Francisco, CA, USA.

Annually, approximately 50,000 patients undergo hematopoietic stem cell transplantation (HCT) worldwide with almost 22,000 of these patients receiving HCT in the United States. HCT is a curative option for a wide range of hematologic malignancies and advances in transplantation medicine have resulted in an increase in HCT survivors. It is anticipated that the number of HCT survivors will more than double from 242,000 in 2020 to approximately 500,000 in 2030. Read More

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http://dx.doi.org/10.1002/phar.2443DOI Listing

Targeted and immunotherapies in BRAF mutant melanoma - where we are standing and what to expect.

Authors:
X Bai K T Flaherty

Br J Dermatol 2020 Jul 11. Epub 2020 Jul 11.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

The therapeutic landscape for melanoma evolved drastically in the past decade. Currently, immune checkpoint inhibitors and small molecule inhibitors targeting the MAPK pathway are the two mainstay therapies for BRAF V600 mutant advanced melanoma. Although MAPK dependence has been variably demonstrated in melanomas lacking BRAF V600 mutations, definitive evidence of benefit with MAPK inhibitors has not been demonstrated. Read More

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http://dx.doi.org/10.1111/bjd.19394DOI Listing

Remdesivir during induction chemotherapy for newly diagnosed paediatric acute lymphoblastic leukaemia with concomitant SARS-CoV-2 infection.

Br J Haematol 2020 Jul 11. Epub 2020 Jul 11.

Department of Haematology, Great Ormond Street Hospital for Children NHS Trust, London, UK.

The COVID-19 pandemic potentially makes treatment of acute leukaemia more difficult. Most induction chemotherapy regimens for acute leukaemia lead to extended periods of cytopaenia and immunosuppression rendering patients vulnerable to opportunistic infections. As with many aspects of SARS-CoV-2, there is no universally accepted way of treating patients who present with acute leukaemia and associated infection. Read More

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http://dx.doi.org/10.1111/bjh.17014DOI Listing

Prognostic impact of tumor location in resected gallbladder cancer: A national cohort analysis.

J Surg Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, City of Hope National Medical Center, Duarte, California.

Background And Objectives: Tumor location (peritoneal vs hepatic) has been incorporated in the 8th edition of the American Joint Committee on Cancer Staging system for gallbladder cancer. However, larger studies are needed to confirm the prognostic impact of tumor location.

Methods: Patients with pathologically-confirmed gallbladder cancer with information on primary tumor location were included from the National Cancer Database (2009-2012). Read More

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http://dx.doi.org/10.1002/jso.26107DOI Listing

NICE Guidelines: management of colorectal cancer metastases.

Br J Surg 2020 Jul 11. Epub 2020 Jul 11.

Clinical Operational Research Unit, University College London, London, UK.

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http://dx.doi.org/10.1002/bjs.11789DOI Listing

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection risk during elective peri-operative care: a narrative review.

Anaesthesia 2020 Jul 11. Epub 2020 Jul 11.

Consultant, Department of Anaesthesia, Peri-operative Medicine, Pain and Critical Care, Royal Marsden Hospital NHS Foundation Trust, London, UK.

The protection of healthcare workers from the risk of nosocomial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a paramount concern. SARS-CoV-2 is likely to remain endemic and measures to protect healthcare workers against nosocomial infection will need to be maintained. This review aims to inform the assessment and management of the risk of SARS-CoV-2 transmission to healthcare workers involved in elective peri-operative care. Read More

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http://dx.doi.org/10.1111/anae.15221DOI Listing

Spontaneously occurring melanoma in animals and their relevance to human melanoma.

J Pathol 2020 Jul 11. Epub 2020 Jul 11.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

In contrast to other cancer types, melanoma incidence has been increasing over the last 50 years, and while it still represents less than 5% of all cutaneous malignancies, melanoma accounts for the majority of skin cancer deaths, due to its propensity to metastasise. Whilst melanoma most commonly affects the skin, it can also arise in mucosal surfaces, the eye and the brain. For new therapies to be developed, a better understanding of the genetic landscape, signalling pathways and tumour-microenvironmental interactions are needed. Read More

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http://dx.doi.org/10.1002/path.5505DOI Listing

Primary Intrathoracic Neurogenic Tumors: Clinical, Pathological, and Long-Term Outcomes.

Thorac Cardiovasc Surg 2020 Jul 11. Epub 2020 Jul 11.

Division of Thoracic Surgery, European Institute of Oncology, IRCCS, Milan, Italy.

Background:  Intrathoracic neurogenic tumors (INTs) are uncommon neoplasms arising from nerve tissues. We report our single-center experience in treating these rare INTs.

Methods:  Using a prospective institutional database, clinical, surgical, and pathological records of patients receiving resection of INT between May 1998 and June 2018 were analyzed. Read More

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http://dx.doi.org/10.1055/s-0040-1712499DOI Listing

Clinical characteristics and outcome of SARS-CoV-2 infection in Italian pediatric oncology patients: a study from the Infectious Diseases Working Group of the AIEOP.

J Pediatric Infect Dis Soc 2020 Jul 11. Epub 2020 Jul 11.

Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

Background: Little is known as yet about the outcome of SARS-CoV-2 infection in children being treated for cancer.

Methods: We collected information on the clinical characteristics and outcomes of a cohort of 29 children (16 females and 13 males, median age 7 years, range [0-16]) diagnosed with SARS-CoV-2 infection while on chemotherapy/immunotherapy (N=26), or after stem cell transplantation (N=3) during the peak of the epidemic in Italy. These patients suffered from leukemia (N=16), lymphoma (N=3), solid tumors (N=10), and Langerhans cell histiocytosis (N=1). Read More

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http://dx.doi.org/10.1093/jpids/piaa088DOI Listing

The circular RNA circEIF3M promotes breast cancer progression by promoting cyclin D1 expression.

Aging (Albany NY) 2020 Jul 11;12. Epub 2020 Jul 11.

Department of General Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.

We investigated the function of circular RNA circEIF3M (hsa_circ_0003119) in triple-negative breast cancer. The expression profiles of circRNAs in 3 specimens of triple-negative breast cancer tissues with adjacent nontumor tissues were analyzed by RNA-sequencing. We verified the oncogenic role of circEIF3M in triple-negative breast cancer through a series of biological function experiments. Read More

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http://dx.doi.org/10.18632/aging.103539DOI Listing

A model based on tumor-infiltrating immune cells for predicting the relapse rates of patients with testicular germ cell tumors.

Int Immunopharmacol 2020 Jul 8;86:106710. Epub 2020 Jul 8.

Department of Urology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. Electronic address:

Objective: The activities of tumor-infiltrating immune cells (TIICs) play an important role in the outcomes of many types of cancers. Here, we sought to describe the landscape of TIICs in testicular germ cell tumors (TGCT) and to develop a prognostic model based on this information.

Methods: The Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm was used to determine the proportions of 22 types of TIICs in a TGCT dataset (n = 74). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106710DOI Listing

Sudden death by massive systemic embolism from cardiac myxoma. Role of the clinical autopsy and review of literature.

Cardiovasc Pathol 2020 May 23;49:107244. Epub 2020 May 23.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy.

Cardiac myxoma is a rare benign neoplasm of the heart. Historically myxomas were incidental findings during autopsies, however improved imaging techniques made these diagnosis possible in living patients, making the surgical treatment of these neoplasms achievable. Cardiac myxomas may occur both sporadically and in a familial context, often in the clinico-pathological picture of the Carney complex. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107244DOI Listing

Cost-effectiveness of routine calcitonin screening and fine-needle aspiration biopsy in preoperative diagnosis of medullary thyroid Cancer in the United States.

Oral Oncol 2020 Jul 8;110:104878. Epub 2020 Jul 8.

Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA; Division of Thyroid and Parathyroid Endocrine Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Objectives: examine the cost-effectiveness of routine Calcitonin (Ctn) screening test in the United States.

Materials And Methods: Markov chain model was developed that compares fine-needle aspiration biopsy (FNAB) with Ctn screening vs. FNAB-only in the evaluation of a thyroid nodule with non-highly suspicious findings. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104878DOI Listing

Lymph node-to-primary tumor standardized uptake value ratio on PET predicts distant metastasis in nasopharyngeal carcinoma.

Oral Oncol 2020 Jul 8;110:104756. Epub 2020 Jul 8.

Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Department of Radiation Oncology, Chang Gung Memorial Hospital at Xiamen, Xiamen, China. Electronic address:

Objectives: To investigate the prognostic value of the relative maximum standardized uptake value (SUV) ratio between neck lymph node and primary tumor (NTR) measured by pretreatment F-FDG PET in patients with nasopharyngeal carcinoma (NPC).

Materials And Methods: We retrospectively reviewed patients with non-disseminated NPC who underwent PET scans before radical intensity-modulated radiotherapy (IMRT). Receiver operating characteristic analysis was performed to identify the optimal cut-off value for NTR. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104756DOI Listing

Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer.

Transl Oncol 2020 Jul 8;13(10):100828. Epub 2020 Jul 8.

Vanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, 1161 21(st) Avenue South, Medical Center North, R0102, Nashville, TN 37232, United States; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Avenue South, Medical Center North, R0102, Nashville, TN 37232, United States; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, Medical Center North, Nashville, TN 37232, United States; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, United States. Electronic address:

Improving response to epidermal growth factor receptor (EGFR)-targeted therapies in patients with advanced wild-type (WT) RAS colorectal cancer (CRC) remains an unmet need. In this preclinical work, we evaluated a new therapeutic combination aimed at enhancing efficacy by targeting cancer cell metabolism in concert with EGFR. We hypothesized that combined blockade of glutamine metabolism and EGFR represents a promising treatment approach by targeting both the "fuel" and "signaling" components that these tumors need to survive. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100828DOI Listing

CpG-coated Prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma.

Transl Oncol 2020 Jul 8;13(10):100823. Epub 2020 Jul 8.

The George Washington Cancer Center, The George Washington University, Washington, DC 20052, USA; The Institute for Biomedical Sciences, The George Washington University, Washington, DC 20037, USA; Department of Medicine, The George Washington University, Washington, DC 20037, USA. Electronic address:

High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucleotide-coated Prussian blue nanoparticles (CpG-PBNPs) combined with anti-CTLA-4 (aCTLA-4) immunotherapy. Our in vitro studies demonstrate that in addition to causing ablative tumor cell death, our nanoimmunotherapy alters the surface levels of co-stimulatory, antigen-presenting, and co-inhibitory molecules on neuroblastoma tumor cells. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100823DOI Listing

Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging.

Transl Oncol 2020 Jul 8;13(10):100822. Epub 2020 Jul 8.

Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. Electronic address:

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-repair enzymes that recognizes and excises DNA lesions and then a polymerase and a ligase incorporate fluorescent nucleotides at the damage sites, resulting in a fluorescent "spot" at each site. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100822DOI Listing

Candidate biomarker assessment for pharmacological response.

Transl Oncol 2020 Jul 8;13(10):100830. Epub 2020 Jul 8.

Developmental Therapeutic Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.

Using the information from our CellMiner (https://discover.nci.nih. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100830DOI Listing

Cu isotope ratios are meaningful in ovarian cancer diagnosis.

J Trace Elem Med Biol 2020 Jul 3;62:126611. Epub 2020 Jul 3.

ISTerre, Université Grenoble Alpes, CS 40700, 38058 Grenoble, France.

Background: Ovarian cancer diagnosis is currently based on imaging and circulating CA-125 concentrations with well-known limits to sensitivity and specificity. New biomarkers are required to complement CA-125 testing to increase effectiveness. Increases in sensitivity of isotopic separation via multi collector inductively coupled plasma-mass spectrometry have recently allowed highly accurate measurement of copper (Cu) isotopic variations. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126611DOI Listing
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