1,792 results match your criteria Cancer detection and prevention[Journal]


Melanoma metastasis to the breast: a diagnostic pitfall.

Cancer Detect Prev 2009 ;32(5-6):458-61

Istanbul University, Istanbul Faculty of Medicine, Internal Medicine, 34390, Capa, Istanbul, Turkey.

Background: Breast metastasis is an extremely rare phenomenon. While nearly every malignancy has been described to metastasize to the breast; melanoma, lymphoma and leukemia tend to be the most common. Among these primary tumors, melanoma metastasis represents a diagnostic pitfall for both the clinicians and histopathologists. Read More

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http://dx.doi.org/10.1016/j.canep.2009.04.001DOI Listing
August 2009
5 Reads

Development of a rat model by 3,4-benzopyrene intra-pulmonary injection and evaluation of the effect of green tea drinking on p53 and bcl-2 expression in lung carcinoma.

Cancer Detect Prev 2009 ;32(5-6):444-51

Department of Respiratory Medicine, Xiangya Hospital affiliated to Central South University, Changsha City, Hunan 410008, PR China.

Background: A convenient animal model of primary lung cancer is compelling for investigation into the disease mechanisms and for development of therapeutic strategies. This study aims to develop a reproducible rat model for lung carcinoma by intra-pulmonary injection of 3,4-benzopyrene, and to evaluate the preventive effect of green tea on the formation of lung carcinoma.

Methods: Sprague-Dawley rats of the same ages were randomly assigned into three groups treated differently. Read More

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http://dx.doi.org/10.1016/j.canep.2009.04.002DOI Listing
August 2009
7 Reads

Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population.

Cancer Detect Prev 2009 ;32(5-6):395-402

Laboratory of Genetic, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunisia.

Background: Cigarette smoking is the predominant risk factor for bladder cancer. This risk may be modified by polymorphisms in carcinogens metabolism genes; including those involving the N-acetyl transferase 2 (NAT2) which have been correlated with decreased enzyme activities. Moreover, folate insufficiency can induces carcinogenesis by decreasing DNA methylation. Read More

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http://dx.doi.org/10.1016/j.canep.2009.04.005DOI Listing
August 2009
25 Reads
4 Citations

Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians.

Cancer Detect Prev 2009 ;32(5-6):386-94

Institute of Pathology, Safdarjang Hospital Campus, New Delhi 110029, India.

Background: Vitamin D (1,25-dihydroxyVitamin D3) has shown experimentally anticarcinogenic effects and is thought to protect against breast cancer. The actions of Vitamin D are mediated via the Vitamin D receptor (VDR), and the polymorphisms at 3'UTR region of this gene are associated with the risk and progression of breast carcinoma. The current study is an attempt to examine the association of these variations with breast cancer risk in north Indians. Read More

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http://dx.doi.org/10.1016/j.canep.2009.04.012DOI Listing
August 2009
7 Reads

Epidemiology of primary brain tumors in the Middle Eastern population in California, USA 2001-2005.

Cancer Detect Prev 2009 ;32(5-6):363-71

Public Health Institute, California Cancer Registry, California, USA.

Background: The fast growing Middle Eastern (ME) population has rarely been studied in the U.S.. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785228PMC
http://dx.doi.org/10.1016/j.canep.2009.04.007DOI Listing
August 2009
3 Reads

Lifetime consumption of alcoholic beverages and risk of 13 types of cancer in men: results from a case-control study in Montreal.

Cancer Detect Prev 2009 ;32(5-6):352-62

Department of Medicine, McGill University, Montreal, Canada.

Background: The aim of the study was to investigate the association between lifetime consumption of alcoholic beverages and cancer risk.

Methods: Data were collected in a population-based case-control study, conducted in Montreal in the mid-1980s, designed to assess the associations between hundreds of non-occupational and occupational exposures and multiple cancer sites in men. We present results for 13 cancer sites: oesophagus (n = 78), stomach (n = 215), colon (n = 427), rectum (n = 239), liver (n = 28), pancreas (n = 83), lung (n = 700), melanoma (n = 107), prostate (n = 374), bladder (n = 425), kidney (n = 156), Hodgkin's lymphoma (n = 42), and non-Hodgkin's lymphoma (n = 190), in comparison to population controls (n = 507). Read More

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http://dx.doi.org/10.1016/j.canep.2009.03.001DOI Listing
August 2009
30 Reads

Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.

Cancer Detect Prev 2009 20;32(5-6):416-23. Epub 2009 Mar 20.

Department of Urology, First Affiliated Hospital, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China.

Objective: To explore the association of polymorphisms in N-acetyltransferase 2 (NAT2), glutathione S-transferase (GST), cytochrome P450 (CYP) 2A6, and CYP 2A13 genes with susceptibility and clinicopathologic characteristics of bladder cancer in a Chinese population.

Methods: In a hospital-based case-control study of 208 cases and 212 controls matched on age and gender, genotypes were determined by PCR-based methods. Risks were evaluated by unconditional logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.cdp.2009.02.003DOI Listing
August 2009
58 Reads

Quantitative assessment of red meat or processed meat consumption and kidney cancer.

Cancer Detect Prev 2009 19;32(5-6):340-51. Epub 2009 Mar 19.

Exponent Health Sciences, 185 Hansen Court, Suite 100, Wood Dale, IL 60191, USA.

Objective: To conduct a quantitative assessment of red meat or processed meat consumption and kidney cancer.

Methods: We extracted data from 12 case-control studies, three cohort studies, and the Pooling Project of Diet and Cancer publication for which 13 international cohorts were evaluated. Random effects meta-analysis models were used to calculate summary relative risk estimates (SRRE) based on high vs. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0361090X0900014
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http://dx.doi.org/10.1016/j.cdp.2009.02.002DOI Listing
August 2009
8 Reads

Haplotype-tagging single nucleotide polymorphisms in the GSTP1 gene promoter and susceptibility to lung cancer.

Cancer Detect Prev 2009 17;32(5-6):403-15. Epub 2009 Mar 17.

Laboratory of Human Toxicology and Molecular Epidemiology, Wadsworth Center, New York State Department of Health, Albany, NY, USA.

Background: Glutathione S-transferase (GST) P1 is a major phase II xenobiotic-metabolizing enzyme in the human lung. Our laboratory had previously identified nine single nucleotide polymorphisms (SNPs) in the GSTP1 gene promoter, which were then grouped into three main haplotypes (Hap1, Hap2, and Hap3) based on statistical inference. Hap3 was found to display a high expression phenotype. Read More

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http://dx.doi.org/10.1016/j.cdp.2009.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730463PMC
August 2009
4 Reads

Cervical cancer screening in medically underserved California Latina and non-Latina women: effect of age and regularity of Pap testing.

Cancer Detect Prev 2009 4;32(5-6):372-9. Epub 2009 Mar 4.

Department of Pathology and Laboratory Medicine, University of California, Davis School of Medicine, 4400 V Street, Sacramento, CA 95817, USA.

Background: This study focuses on age, race/ethnicity and regular cervical cancer screening of medically underserved Latina and non-Latina women enrolled in California's Cancer Detection Programs: Every Woman Counts (CDP: EWC).

Methods: Data from a cohort of women were evaluated for regularity of screening and ethnicity utilizing multi-category logistic regression models to investigate Pap test and biopsy results.

Results: There was no statistically significant difference among medically underserved Latina or non-Latina women in Pap test result and stage of cervical cancer after controlling for age and screening regularity. Read More

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http://dx.doi.org/10.1016/j.cdp.2009.02.001DOI Listing
August 2009
6 Reads

A deficit in biopsying potentially premalignant oral lesions in Puerto Rico.

Cancer Detect Prev 2009 27;32(5-6):424-30. Epub 2009 Feb 27.

New York University College of Dentistry, Department of Epidemiology & Health Promotion, New York, NY 10003-1402, USA.

Background: Intraoral lesions clinically suspicious for cancer/precancer should be biopsied and diagnosed histopathologically. We evaluated whether the frequency of oral cancer (OC) cases diagnosed in Puerto Rico (PR) is disproportionately high relative to the frequency of persons with histopathologic diagnoses that would have appeared clinically suspicious for OC/precancer at biopsy.

Methods: All pathology reports for oral (ICD-O-3 C01-C06) soft tissue biopsies generated during 1/2004-5/2005 by seven PR and two New York City (NYC) pathology laboratories were reviewed. Read More

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http://dx.doi.org/10.1016/j.cdp.2009.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705785PMC
August 2009
4 Reads

MDM2 SNP309T>G polymorphism and risk of hepatocellular carcinoma: a case-control analysis in a Moroccan population.

Cancer Detect Prev 2009 23;32(5-6):380-5. Epub 2009 Feb 23.

Laboratoire de Virologie, Institut Pasteur du Maroc, Casablanca, Morocco.

Background: The Murine double minute 2 (MDM2) gene encodes a negative regulator of the p53 tumor suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumor formation. The aim of this study was to investigate whether this functional SNP is associated with an enhanced risk of liver tumorigenesis in Moroccan patients. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0361090X0900004
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http://dx.doi.org/10.1016/j.cdp.2009.01.003DOI Listing
August 2009
13 Reads

High expression of alpha 2, 3-linked sialic acid residues is associated with the metastatic potential of human gastric cancer.

Cancer Detect Prev 2009 18;32(5-6):437-43. Epub 2009 Feb 18.

Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.

Background: Sialic acid, as a terminal saccharide residue on cell surface glycoconjugates, plays an important role in a variety of biological processes. However, the precise nature of the molecules in gastric cancers has not been unveiled nor documented to be of clinical relevance. Herein, we measured the expression of alpha 2, 3-linked sialic acid residues by using a specific lectin as well as the potential of invasion and metastasis of gastric cancer was analyzed. Read More

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http://dx.doi.org/10.1016/j.cdp.2009.01.001DOI Listing
August 2009
9 Reads

Specific thermographic changes during Walker 256 carcinoma development: differential infrared imaging of tumour, inflammation and haematoma.

Cancer Detect Prev 2009 20;32(5-6):431-6. Epub 2009 Feb 20.

Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.

Background: Infrared imaging measures spatial variations in the skin temperature aiming to determine pathological processes; hence possible use of this non-invasive analytical method in cancer detection is emerging.

Methods: Infrared thermal imaging was used to detect changes in rat skin surface temperature associated with experimental cancer development (Walker 256 carcinoma), inflammation (upon s.c. Read More

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http://dx.doi.org/10.1016/j.cdp.2009.01.002DOI Listing
August 2009
4 Reads

Prostate cancer diagnosis: should patients with prostate specific antigen >10ng/mL have stratified prostate biopsy protocols?

Cancer Detect Prev 2009 3;32(4):314-8. Epub 2009 Feb 3.

Department of Urology, Leighton Hospital, Crewe, Cheshire, CW1 4QJ UK.

Background: Trans-rectal ultrasound (TRUS) guided systematic prostate biopsy is a standard tool in prostate cancer (CaP) diagnosis. Extended biopsy techniques using 10-12 cores are the norm. Controversy exists on extended TRUS biopsy in men with PSA>10ng/mL. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.12.004DOI Listing
April 2009
3 Reads

Rh factor, family history and risk of breast cancer: a case-control study in Uruguay.

Cancer Detect Prev 2009 1;32(4):277-85. Epub 2009 Feb 1.

Departamento de Epidemiología y Métodos Científicos, Facultad de Medicina, IUCLAEH, Maldonado, Uruguay.

Objective: To explore possible relationships among blood factors, family history of breast cancer (BC) and the risk of the disease, a case-control study was carried out in Montevideo, Uruguay.

Methods: Eight hundred and one patients were interviewed, including 252 certified cases of BC and 549 frequency-matched controls. Blood groups (ABO, Rh) were obtained from medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0361090X080013
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http://dx.doi.org/10.1016/j.cdp.2008.12.005DOI Listing
April 2009
1 Read

Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines.

Cancer Detect Prev 2009 30;32(4):319-28. Epub 2009 Jan 30.

Department of Biological Sciences, and Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.

Background: The purpose of our study was to show the apoptotic and anti-proliferative effects of phytosterols as distinct from cholesterol effects on prostate cancer cell lines, and also their differential expression of caveolin-1, and a prostate specific gene, PCGEM1.

Methods: PC-3 and DU145 cells were treated with sterols (cholesterol and phytosterols) for 48h, followed by trypan blue dye exclusion measurement of cytotoxicity and MTT cell proliferation assays, respectively. Cell cycle analysis was carried out microscopically, and by propidium iodide uptake using flow cytometry. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.12.002DOI Listing
April 2009
35 Reads
6 Citations

Differential expression of survivin and its splice variants, survivin-DeltaEx3 and survivin-2B, in bladder cancer.

Cancer Detect Prev 2009 30;32(4):308-13. Epub 2009 Jan 30.

Department of Genetics, Faculty of Basic Sciences, Tarbiat Modares University, P.O. Box 14115-175 Tehran, Iran.

Background: Survivin, an inhibitor of apoptosis protein (IAP), has been regarded as a valuable tumor marker for diagnosis and prognosis of bladder cancer. Recently, three splice variants of the gene with different anti-apoptotic activities have been reported. However, there is no data on the expression and potential causative roles of these transcripts in bladder cancer. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.12.001DOI Listing
April 2009
12 Reads

Effects of emodin on the gene expression profiling of human breast carcinoma cells.

Cancer Detect Prev 2009 30;32(4):286-91. Epub 2009 Jan 30.

Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China.

Background: The mechanism of emodin-mediated cell apoptosis has been investigated extensively in many types of human cancer cells. Our previous study demonstrated that emodin induced apoptosis through the decrease of Bcl-2/Bax ratio and the increase of cytoplasm cytochrome c concentration in human breast cancer BCap-37 cells. However, emodin's reaction to breast cancer cells remains elusive. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0361090X0800131
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http://dx.doi.org/10.1016/j.cdp.2008.12.003DOI Listing
April 2009
4 Reads

Chemopreventive action of dexamethasone and alpha-tocopherol in oxidative stressed cells.

Cancer Detect Prev 2009 13;32(5-6):452-7. Epub 2008 Dec 13.

Department of Otolaryngology and Head and Neck Surgery, Ludwig-Maximilians-University, Marchioninist, 15, 81377 Munich, Germany.

Introduction: Recent research indicates a close connection of inflammation and cancer as presumed by Virchow in 1893. The growing understanding of cellular signalling and regulatory pathways reveals multiple links between inflammation and cancer. This study was designed to evaluate the influence of the anti-inflammatory drug dexamethasone and the antioxidant alpha-tocopherol on oxidative induced DNA damage, a major factor in the development of malignancies. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.10.002DOI Listing
August 2009
1 Read

Low level anti-Hu reactivity: A risk marker for small cell lung cancer?

Cancer Detect Prev 2009 12;32(4):292-9. Epub 2008 Dec 12.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA.

Background: Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design.

Methods: We used stored plasma specimens to evaluate anti-Hu reactivity in relationship to small cell lung cancer in a population-based case-control study. Using Western Blot analysis, we measured anti-Hu reactivity against recombinant Hu family member, HuD, in plasma samples from 41 SCLC cases and 79 controls individually matched for age, race, sex, and smoking status (never, past, current). Read More

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http://dx.doi.org/10.1016/j.cdp.2008.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952929PMC
April 2009
2 Reads

Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia.

Cancer Detect Prev 2009 20;32(4):336-7. Epub 2008 Nov 20.

Background: Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells.

Methods: The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH).

Results: Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa5. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.10.001DOI Listing
April 2009
56 Reads

Cervical carcinoma in Southern Mexico: Human papillomavirus and cofactors.

Cancer Detect Prev 2009 20;32(4):300-7. Epub 2008 Nov 20.

Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico.

Background: This study was conducted to determine human papillomavirus (HPV) types in women with cervical cancer (CC) and normal cervical cytology in the Southern region of Mexico, and to know the contribution of HPV types and cofactors in cervical cancer etiology.

Methods: A case-control study was performed in 133 women with CC and 256 controls. HPV detection was done by MY09/11 and GP5+/GP6+ PCR systems and typing by restriction fragment length polymorphism or DNA sequencing. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.09.001DOI Listing
April 2009
15 Reads

Breast cancer tumor markers: worthless or beneficial?

Cancer Detect Prev 2008 24;32(3):188-9. Epub 2008 Sep 24.

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http://dx.doi.org/10.1016/j.cdp.2008.08.007DOI Listing
December 2008
3 Reads

Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck.

Cancer Detect Prev 2008 20;32(3):200-8. Epub 2008 Sep 20.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA.

Background: The Pentose Phosphate Pathway (PPP) is involved in the body's protection against oxidative stress and resistance/susceptibility to apoptosis and thus has been implicated in tumor development and progression. Here we present data examining the association of genetic variation in one of the key enzymes of the PPP, Transaldolase 1 (TALDO1) with squamous cell carcinoma of the head and neck (SCCHN).

Methods: We performed sequencing analysis to identify common genetic variations in TALDO1 and then investigated their association with SCCHN using samples from a population-based case/control study with both European American (EA) and African American (AA) former and current smokers. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614275PMC
December 2008
1 Read

Examining the characteristics of unstaged colon and rectal cancer cases.

Cancer Detect Prev 2008 19;32(3):251-8. Epub 2008 Sep 19.

Division of Gastroenterology, Case Western Reserve University, Cleveland, OH 44106-4952, USA.

Background: There are only three published studies that have examined unstaged cancers, including breast, prostate and colorectal cancer, but none have specifically examined which aspects of tumor staging were missing. The objective of the study was to identify which stage components were missing, to characterize and to identify predictors of unstaged cancer, and to evaluate prognosis of unstaged in colon and rectal cancer patients.

Methods: Data on all colon and rectal cancer cases diagnosed during 1991 to 2002 were identified from the Surveillance, Epidemiology and End Results (SEER) database. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.08.006DOI Listing
December 2008
3 Reads

Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer.

Cancer Detect Prev 2008 17;32(3):236-50. Epub 2008 Sep 17.

Medical Oncology and Institute for Biomedical Research (INIBIC), Juan Canalejo University Hospital, Spain.

Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative polymerase chain reaction (PCR) amplification of tissue or tumor selective mRNA is the most powerful tool for the detection of this circulating or occult metastatic cells. Our study aims to identify novel gastrointestinal cancer-specific markers for circulating tumor cell detection. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.08.002DOI Listing
December 2008
21 Reads

Impact of a print intervention to increase annual mammography screening among Korean American women enrolled in the National Breast and Cervical Cancer Early Detection Program.

Cancer Detect Prev 2008 16;32(3):229-35. Epub 2008 Sep 16.

Division of Cancer Prevention & Control Research, School of Public Health/Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-6900, USA.

Background: Although Korean American women have one of the lowest rates of mammography screening, only few interventions have been developed for them. We developed a theory-based Korean-language print intervention to increase annual mammography screening with the goal to disseminate it through the National Breast and Cervical Cancer Early Detection Program (NBCCEDP).

Methods: Korean American staff and patients at a community clinic advised on the content and layout of the brochure. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0361090X0800060
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http://dx.doi.org/10.1016/j.cdp.2008.04.003DOI Listing
December 2008
3 Reads

Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers.

Cancer Detect Prev 2008 13;32(3):190-9. Epub 2008 Sep 13.

Connecticut Tumor Registry, Connecticut Department of Public Health, 410 Capitol Avenue, Hartford, CT 06134-0308, USA.

Background: Reaching the American Cancer Society challenge goal for the nation to reduce cancer incidence by 25% by 2015 will be influenced in part by the epidemic of obesity. The purpose of this study was to estimate the impact of obesity on the number obesity-attributable incident cancers in the U.S. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0361090X0800103
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http://dx.doi.org/10.1016/j.cdp.2008.08.004DOI Listing
December 2008
7 Reads

Tumor size and detection in breast cancer: Self-examination and clinical breast examination are at their limit.

Cancer Detect Prev 2008 13;32(3):224-8. Epub 2008 Sep 13.

University Hospital Basel, Department of Gynecology and Obstetrics, Spitalstrasse 21, CH-4031 Basel, Switzerland.

Background: This study investigates to what extent tumor detection methods in breast cancer have changed and how this has influenced tumor size at initial diagnosis.

Methods: 1054 breast carcinomas < or =5 cm, newly diagnosed between 1990 and 2006, were evaluated for the tumor detection methods used, namely self-detection (SD, n=568), clinical breast examination (CBE, n=212), and radiological breast examination (RBE, n=237), and their corresponding tumor sizes.

Results: During the study period, the proportion of cases found by RBE increased (p<0. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S0361090X0800061
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http://dx.doi.org/10.1016/j.cdp.2008.04.002DOI Listing
December 2008
4 Reads

Early age at first childbirth associated with advanced tumor grade in breast cancer.

Cancer Detect Prev 2008 11;32(3):215-23. Epub 2008 Sep 11.

The George Washington University School of Public Health and Health Services, Department of Epidemiology and Biostatistics, 2300 Eye Street, N.W., Ross Hall 118, Washington, DC 20037, USA.

Background: Many studies have investigated risk factors for developing breast cancer, but few have explored whether these risk factors are associated with the aggressiveness of the tumor. This case-case study examined the relationship between risk factors for breast cancer and the histological grade of the tumor at diagnosis, an important indicator of breast cancer aggressiveness.

Methods: We interviewed 215 breast cancer patients and obtained information on their demographics, reproductive history and hormone use. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.04.001DOI Listing
December 2008
4 Reads

Interval from diagnosis to treatment onset for six major cancers in Catalonia, Spain.

Cancer Detect Prev 2008 11;32(3):267-75. Epub 2008 Sep 11.

Agència de Salut Pública de Barcelona, Barcelona, Spain; Universitat Pompeu Fabra, Catalonia, Spain.

Background: Targets set by health care organizations on time intervals between cancer diagnosis and treatment often go unmet. The objective of the study was to analyse the interval from diagnosis to treatment onset, and related factors, in the six most incident cancers in Catalonia (Spain), a developed European region with universal free access to health care.

Methods: Twenty-two hospitals contributed 1023 incident cancer patients (198 lung, 253 colorectal, 95 prostate, 109 urinary bladder, 266 breast, 102 endometrial). Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.006DOI Listing
December 2008
5 Reads

Smoking cessation advice: Swiss physicians lack training.

Cancer Detect Prev 2008 11;32(3):209-14. Epub 2008 Sep 11.

Respiratory Medicine, Department of Medicine, Basel University Hospital, 4031 Basel, Switzerland.

Objectives: To assess the use and appropriateness of medical advice for smoking cessation provided by registrars in a General Medicine Outpatient Department to an unselected patient population in Switzerland.

Methods: A prospective observational study in which 314 consecutive outpatients were contacted by phone within 24h after their consultation. Questions and information concerning smoking asked and/or provided by the registrar to patients were collected. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.08.001DOI Listing
December 2008
4 Reads

Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer.

Cancer Detect Prev 2008 11;32(3):259-66. Epub 2008 Sep 11.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Background: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is expressed in certain human cancers. Ligand-induced PPAR-gamma activation can result in growth inhibition and differentiation in these cancer cells; however, the precise mechanism for the anti-proliferative effect of PPAR-gamma ligands is not clear.

Methods: In this study, we examined the expression of PPAR-gamma in human prostate cancer and the effect of two PPAR-gamma ligands, 15 deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and troglitazone, on prostate cancer cell growth. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.008DOI Listing
December 2008
10 Reads

The p53 Arg72Pro and Ins16bp polymorphisms and their haplotypes are not associated with breast cancer risk in BRCA-mutation negative familial cases.

Cancer Detect Prev 2008 21;32(2):140-3. Epub 2008 Jul 21.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.

Background: Germline disease-causing mutations in BRCA1 and BRCA2 genes confer high risk of breast and ovarian cancer, but account approximately for only 15% of familial cases. Theoretical models and experimental observations have indicated that the remaining familial aggregations would be explained by low-penetrance alleles. Moreover, alleles acting as genetic modifiers would modulate the breast cancer risk in carriers of BRCA mutations. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.06.003DOI Listing
September 2008
2 Reads

Specific chromosomal aberrations in de novo acute myeloid leukemia: a comparative analysis of results with a report of three novel chromosomal rearrangements t(7;14)(q35;q13), t(8;18)(p11.2;q12), t(13;15) in Indian population.

Cancer Detect Prev 2008 18;32(2):168-77. Epub 2008 Jul 18.

Research and Development, SRL Ranbaxy Ltd., 17th Street, MIDC, Andheri (E), Mumbai 400093, India.

Background: Acute myeloid leukemia (AML) is a heterogeneous disease with regard to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in AML.

Method: Conventional cytogenetic analysis was done on 200 de novo AML subjects. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.007DOI Listing
September 2008
4 Reads

Breast cancer mortality in Barcelona following implementation of a city breast cancer-screening program.

Cancer Detect Prev 2008 18;32(2):162-7. Epub 2008 Jul 18.

CIBER de Epidemilogia y Salud Pública (CIBERESP), Agència de Salut Pública de Barcelona, Plaça Lesseps 1, 08023 Barcelona, Spain.

Background: To assess the impact that the Barcelona city breast cancer-screening program has had in the decline of mortality due to breast cancer among women aged 50-74 years, in the city of Barcelona.

Methods: A quasi-experimental study based on breast cancer deaths among women aged between 50 and 74 years residing in Barcelona between 1984 and 2004. The variables used were: age, year, and Primary Health Care District (ABS) grouped into four zones according to the year of implementation of the screening program. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.002DOI Listing
September 2008
39 Reads

Occupational exposure to formaldehyde and biological monitoring of Research Institute workers.

Cancer Detect Prev 2008 18;32(2):121-6. Epub 2008 Jul 18.

Department of Epidemiology and Prevention, Unit of Environmental Chemistry and Carcinogenesis, National Cancer Research Institute, Genoa, Italy.

Aim: The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect.

Methods: Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers.

Results: Individual FA levels of exposure ranged from 4. Read More

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http://www.occup-med.com/content/pdf/1745-6673-5-25.pdf
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http://dx.doi.org/10.1016/j.cdp.2008.05.003DOI Listing
September 2008
5 Reads

Trends in prevalence of prognostic factors and survival in lung cancer patients from 1985 to 2004 at a tertiary care center.

Cancer Detect Prev 2008 17;32(2):101-8. Epub 2008 Jul 17.

Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Background: After a prolonged period of increasing rates of lung cancer incidence and mortality for both men and women, incidence and mortality rates are decreasing in men and stabilizing in women. The goal of this study was to assess changes over 20 years in the prevalence of known risk factors for lung cancer and to elucidate possible predictors associated with lung cancer survival.

Methods: The study included a total of 908 patients with primary lung cancer referred to The University of Texas M. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287275PMC
September 2008
7 Reads

Biomarkers associated with breast cancer are associated with obesity.

Cancer Detect Prev 2008 17;32(2):149-55. Epub 2008 Jul 17.

Department of Surgery, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.

Background: Obesity is linked to the development of postmenopausal breast cancer, and some studies indicate obesity predicts a worse prognosis for premenopausal women who develop the disease. It was our hypothesis that proteins associated with breast cancer would be associated with body mass index (BMI).

Methods: We searched our database of women enrolled in breast health translational research trials for information on BMI and markers predictive of breast cancer (basic fibroblast growth factor (bFGF), prostate-specific antigen (PSA), human kallikrein (hK)2, and urinary plasminogen activator (uPA). Read More

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http://dx.doi.org/10.1016/j.cdp.2008.06.002DOI Listing
September 2008
3 Reads

Tobacco smoking and risk of recurrence for squamous cell cancer of the anus.

Cancer Detect Prev 2008 17;32(2):116-20. Epub 2008 Jul 17.

Department of Surgery, University of California, San Diego, CA 92093-0063, USA.

Objective: Squamous cell cancer of the anus is associated with multiple risk factors, including infection with human papillomavirus, immunosuppression, chronic inflammation, and tobacco smoking, although there is little data on these factors for the prediction of recurrent disease. Here, we evaluated the risk of recurrence and mortality of anal carcinoma in association with tobacco smoking.

Methods: We conducted a retrospective review of cases of anal carcinoma from two local hospitals. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427794PMC
September 2008
3 Reads

Evidence for a programming effect of early menarche on the rise of breast cancer incidence in Hong Kong.

Cancer Detect Prev 2008 16;32(2):156-61. Epub 2008 Jul 16.

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.

Background: Younger age at menarche and older age at first live birth are implicated as risk factors for breast cancer, but the extent to which these factors contribute to the sharply rising incidence of this disease in developing countries has received little study.

Methods: We conducted a retrospective analysis of 702 consecutive breast cancer patients diagnosed at a single hospital in Hong Kong during 2003-2006. Comparisons were made between patients with different ages at cancer diagnosis (hence, belonging to different birth cohorts) and their respective ages at menarche and at first live birth. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.004DOI Listing
September 2008
2 Reads

Loss of heterozygosity in the RAD51 and BRCA2 regions in breast cancer.

Cancer Detect Prev 2008 16;32(2):144-8. Epub 2008 Jul 16.

Department of Cytobiochemistry, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.

Background: Loss of heterozygosity (LOH) in the 15q14-21 and 13q12-13 regions can contribute to the inactivation of RAD51 and BRCA2 genes implicated in the pathogenesis of breast cancer. We investigated allelic losses in microsatellites in the RAD51 and BRCA2 regions, and their association with clinicopathological parameters in breast cancer.

Methods: The LOH analysis was performed by amplifying DNA by PCR, using D15S118, D15S214, D15S1006 polymorphic markers in the 15q14-21 region and D13S260, D13S290 polymorphic markers in the 13q12-13 region in 36 sporadic breast cancer cases. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.06.005DOI Listing
September 2008
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Hypermethylation of epithelial-cadherin gene promoter is associated with Epstein-Barr virus in nasopharyngeal carcinoma.

Cancer Detect Prev 2008 15;32(2):127-34. Epub 2008 Jul 15.

Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rajthevi, Bangkok 10400, Thailand.

Background: Epstein-Barr virus (EBV) is documented as the important etiologic agent of nasopharyngeal carcinoma (NPC) but the mechanism of development and pathogenesis induced by EBV is presently unclear. Hypermethylation of epithelial-cadherin (E-cadherin) promoter has been shown to be induced in NPC cell line by EBV LMP1 via DNA methyltransferase activation. EBV genomes and hypermethylation of E-cadherin promoter were investigated in NPC tissues to evaluate the role of EBV in the hypermethylation and pathogenesis of NPC. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.005DOI Listing
September 2008
8 Reads

COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia.

Cancer Detect Prev 2008 16;32(2):135-9. Epub 2008 Jul 16.

Cancer Genetics Branch, Center for Cancer Research, National Cancer Institute, Rockville, MD 20892, USA.

Background: Previous studies have shown important effects of stromal elements in carcinogenesis. To explore the tumor-stromal relationship in esophageal neoplasia, we examined methylation of COX-2 (PTGS2), a gene etiologically associated with the development of gastrointestinal cancers, in adjacent foci of epithelium, subepithelial lymphocytes and non-lymphocytic stromal cells found in sections of normal squamous epithelium, squamous dysplasia and invasive esophageal squamous cell carcinoma.

Methods: Adjacent foci of epithelium, subepithelial lymphocytic aggregates and non-lymphocytic stromal tissues were laser microdissected from six fully embedded, ethanol fixed, esophagectomy samples from Shanxi, China, a high-risk region for esophageal cancer. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629649PMC
September 2008
5 Reads

The prevalence of signs and symptoms of childhood leukemia and lymphoma in Fars Province, Southern Iran.

Cancer Detect Prev 2008 16;32(2):178-83. Epub 2008 Jul 16.

Hemostasis and Thrombosis Research Unit, Hematology Research Center, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Leukemia and lymphomas are still the common childhood cancers in Iran. This study was undertaken to determine the prevalence of signs and symptoms of these malignancies in children of Fars Province, Southern Iran.

Methods: A total of 368 cases of children who were less than 15 years old and diagnosed as acute lymphocytic leukemia (ALL, n=211), acute myeloid leukemia (AML, n=64), Burkitt lymphoma (BL, n=40), chronic myeloid leukemia (CML, n=5), Hodgkin's disease (HD, n=33) or non-Burkitt-type, non-Hodgkin's lymphoma (NBNHL, n=15) referring to the hospitals of Shiraz University of Medical Sciences from April 1997 to March 2002 were enrolled. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.06.001DOI Listing
September 2008
28 Reads
5 Citations

Which socio-demographic factors are associated with participation in oral cancer screening in the developing world? Results from a population-based screening project in India.

Cancer Detect Prev 2008 16;32(2):109-15. Epub 2008 Jul 16.

Regional Cancer Centre, Medical College Campus, Post Box 2417, Trivandrum 695 011, Kerala State, India.

Background: This study examines socio-demographic determinants of participation in a population-based randomized controlled trial that proved that oral visual inspection was effective in reducing oral cancer mortality in high-risk individuals in India.

Methods: Multivariate logistic regression was used to establish socio-demographic characteristics of participants versus non-participants in the intervention arm. Compliance with referral was analysed according to the socio-demographic characteristics of screen-positives. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.02.008DOI Listing
September 2008

Alcohol drinking and renal cell carcinoma in Canadian men and women.

Cancer Detect Prev 2008 16;32(1):7-14. Epub 2008 Apr 16.

Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, 120 Colonnade Road, AL 6701A, Ottawa, Ontario, Canada.

Background: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cell carcinoma (RCC), but sex-specific results are inconsistent. The present study examines the association between alcohol intake and the risk of RCC among men and women.

Methods: Mailed questionnaires were completed by 1138 newly diagnosed, histologically confirmed RCC cases and 5039 population controls between 1994 and 1997 in eight Canadian provinces. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.02.001DOI Listing
June 2008
7 Citations

Prevention of age-related spontaneous mammary tumors in outbred rats by late ovariectomy.

Cancer Detect Prev 2008 14;32(1):65-71. Epub 2008 Apr 14.

Department of Pharmacology, Penn State College of Medicine, MCH078, 500 University Drive, Hershey, PA 17033, USA.

Background: Breast cancer prevention trials have shown that the antiestrogen tamoxifen inhibits development of estrogen receptor (ER)-positive tumors. In Sprague-Dawley rats, removal of ovarian function in young animals can reduce the incidence of spontaneous age-dependent mammary tumors. However, it is not known whether removal of ovaries late in life, before middle age onset, can still prevent mammary tumor development. Read More

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http://dx.doi.org/10.1016/j.cdp.2008.01.004DOI Listing
June 2008
2 Reads