43,072 results match your criteria Cancer cytopathology[Journal]


Reply to Incidence of extrameningeal solitary fibrous tumors and novel therapeutic approaches in the treatment of solitary fibrous tumors: A call for a combination therapy.

Cancer 2020 Jul 3. Epub 2020 Jul 3.

Adult Mesenchymal and Rare Tumor Unit, Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.33056DOI Listing

Novel therapeutic approaches in the treatment of solitary fibrous tumors: A call for a combination therapy.

Cancer 2020 Jul 3. Epub 2020 Jul 3.

Third Department of Surgery, First Faculty of Medicine, Charles University/Motol University Hospital, Prague, Czech Republic.

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http://dx.doi.org/10.1002/cncr.33055DOI Listing

Incidence of extrameningeal solitary fibrous tumors.

Cancer 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiation Oncology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

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http://dx.doi.org/10.1002/cncr.33057DOI Listing

Physical activity, health-related quality of life, and adjuvant endocrine therapy-related symptoms in women with hormone receptor-positive breast cancer.

Cancer 2020 Jul 2. Epub 2020 Jul 2.

Department of Oncology, Georgetown University, Washington, DC.

Background: Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient-reported symptoms for women on adjuvant endocrine therapy (AET).

Methods: Women with hormone receptor-positive BC who were taking AET completed standardized surveys about their health-related QOL, AET-related symptoms, and levels of PA using validated measures. A Wald chi-square test and an analysis of variance were used to assess associations with PA and independent variables. Read More

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http://dx.doi.org/10.1002/cncr.33054DOI Listing

Measuring financial toxicity incurred after treatment of head and neck cancer: Development and validation of the Financial Index of Toxicity questionnaire.

Cancer 2020 Jun 30. Epub 2020 Jun 30.

Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

Background: The treatment of head and neck cancer (HNC) may cause significant financial toxicity to patients. Herein, the authors have presented the development and validation of the Financial Index of Toxicity (FIT) instrument.

Methods: Items were generated using literature review and were based on expert opinion. Read More

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http://dx.doi.org/10.1002/cncr.33032DOI Listing

Immunocytochemistry practices in European cytopathology laboratories-Review of European Federation of Cytology Societies (EFCS) online survey results with best practice recommendations.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Cochin Hospital, University Paris, Paris, France.

Background: Variability in preanalytical and analytical steps for immunocytochemistry (ICC) on cytology samples is poorly defined. The objective of this study was to evaluate current practices for ICC on cytology samples in European laboratories.

Methods: A link to an online survey with 19 questions about ICC practices was distributed to cytology laboratories through national representatives in the European Federation of Cytology Societies. Read More

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http://dx.doi.org/10.1002/cncy.22311DOI Listing

Health disparities in cervical cancer: Prevalence of high-risk HPV and cytologic diagnoses according to race.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Background: In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and black women compared with white women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among black and white women over a 24-month period. They then assessed the rates in young women in 2011 compared with 2017 according to race. Read More

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http://dx.doi.org/10.1002/cncy.22316DOI Listing

Next-generation sequencing of residual cytologic fixative preserved DNA from pancreatic lesions: A pilot study.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

The Leopold G. Koss Division of Cytology, The Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.

Background: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a sensitive and specific tool in the risk stratification of pancreatic lesions, including cysts. The sensitivity and specificity of EUS-FNA has been shown to improve when cytology is combined with next-generation sequencing (NGS). Ideally, fresh cyst fluid is used for NGS. Read More

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http://dx.doi.org/10.1002/cncy.22315DOI Listing

Research notes largest yearly decline in melanoma deaths.

Authors:
Carrie Printz

Cancer 2020 Jul;126(14):3173

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http://dx.doi.org/10.1002/cncr.33045DOI Listing

Biomarker-driven phase 2 umbrella trial study for patients with recurrent small cell lung cancer failing platinum-based chemotherapy.

Cancer 2020 Jun 25. Epub 2020 Jun 25.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: A high percentage of small cell lung cancer (SCLC) cases harbor cell cycle-related gene mutations and RICTOR amplification. Based on underlying somatic mutations, the authors have conducted a phase 2 biomarker-driven, multiarm umbrella study.

Methods: The SCLC Umbrella Korea StudiES (SUKSES) is an adaptive platform trial that undergoes continual modification according to the observed outcomes. Read More

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http://dx.doi.org/10.1002/cncr.33048DOI Listing

Slicing and dicing small cell lung cancer to improve trial outcomes.

Cancer 2020 Jun 25. Epub 2020 Jun 25.

Division of Hematology and Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1002/cncr.33047DOI Listing

Insulinoma-associated protein 1 immunostaining for various types of neuroendocrine tumors on FNA smears.

Cancer Cytopathol 2020 Jun 23. Epub 2020 Jun 23.

Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Insulinoma-associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin-embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied. This study investigated the performance of INSM1 staining on cytologic smears for the detection of various NETs in comparison with chromogranin (CG) and synaptophysin (SYN).

Methods: INSM1, CG, and SYN were stained on cytologic smears of 70 NETs, including 20 pancreatic NETs, 10 lung carcinoid tumors, 11 small cell lung carcinomas (SCLCs), 10 medullary thyroid carcinomas, 10 Merkel cell carcinomas, 4 thymic atypical carcinoid tumors, and 5 olfactory neuroblastomas. Read More

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http://dx.doi.org/10.1002/cncy.22310DOI Listing

Interobserver variability between cytopathologists and cytotechnologists upon application and characterization of the indeterminate category in the Milan system for reporting salivary gland cytopathology.

Cancer Cytopathol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology and Laboratory Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Background: The indeterminate categories in the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) are diagnostically challenging because of inherent heterogeneity and complexity, with wide interobserver variability (IOV). Herein, the authors explore the concordance rate (CR) between cytopathologists (CPs) and cytotechnologists (CTs) in interpreting indeterminate salivary gland lesions using the MSRSGC.

Methods: Between 2011 and 2016, 86 indeterminate fine-needle aspirations had slides available for review, of which 48 had follow-up. Read More

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http://dx.doi.org/10.1002/cncy.22312DOI Listing

Oncological outcomes for patients with locally advanced prostate cancer treated with neoadjuvant endocrine and external-beam radiation therapy followed by adjuvant continuous/intermittent endocrine therapy in an open-label, randomized, phase 3 trial.

Cancer 2020 Jun 23. Epub 2020 Jun 23.

Institute for Preventive Medicine, Kurosawa Hospital, Takasaki, Japan.

Background: To date, research has not determined the optimal procedure for adjuvant androgen deprivation therapy (ADT) in patients with locally advanced prostate cancer (PCa) treated for 6 months with neoadjuvant ADT and external-beam radiation therapy (EBRT).

Methods: A multicenter, randomized, phase 3 trial enrolled 303 patients with locally advanced PCa between 2001 and 2006. Participants were treated with neoadjuvant ADT for 6 months. Read More

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http://dx.doi.org/10.1002/cncr.33034DOI Listing

Survival in older women with early stage breast cancer receiving low-dose bisphosphonates or denosumab.

Cancer 2020 Jun 23. Epub 2020 Jun 23.

Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Bisphosphonates and denosumab, as adjuvant therapy in breast cancer, have been associated in some studies with improved cancer outcomes. The potential benefits of these drugs used at the lower doses commonly given for osteoporosis have not been established. The objective of this study was to investigate the association between therapy with bone-modifying agents (BMAs) and survival in older women with early breast cancer. Read More

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http://dx.doi.org/10.1002/cncr.33035DOI Listing

Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China.

Cancer 2020 Jun 23. Epub 2020 Jun 23.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Patients with cancer have a higher risk of coronavirus disease 2019 (COVID-19) than noncancer patients. The authors conducted a multicenter retrospective study to investigate the clinical manifestations and outcomes of patients with cancer who are diagnosed with COVID-19.

Methods: The authors reviewed the medical records of hospitalized patients who were treated at 5 hospitals in Wuhan City, China, between January 5 and March 18, 2020. Read More

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http://dx.doi.org/10.1002/cncr.33042DOI Listing

Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.

Cancer 2020 Jun 23. Epub 2020 Jun 23.

Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways are associated with clinical outcomes for individuals who undergo resection.

Methods: Eligible individuals were those who underwent resection of PDAC and consented to targeted sequencing of their primary tumor via Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT). Read More

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http://dx.doi.org/10.1002/cncr.33038DOI Listing

Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis.

Cancer 2020 Jun 22. Epub 2020 Jun 22.

Harvard Medical School, Boston, Massachusetts.

Background: There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of this study was to identify potential factors associated with development of ICI colitis.

Methods: We performed a retrospective analysis of melanoma patients at Dana-Farber Cancer Institute who received PD-1, CTLA-4, or combination ICIs between May 2011 to October 2017. Read More

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http://dx.doi.org/10.1002/cncr.32966DOI Listing

Cancer surveillance and distress among adult pathogenic TP53 germline variant carriers in Germany: A multicenter feasibility and acceptance survey.

Cancer 2020 Jun 18. Epub 2020 Jun 18.

Department of Gynecology and Obstetrics, University Hospital Heidelberg, Heidelberg, Germany.

Background: Li-Fraumeni syndrome (LFS) is a high-risk cancer predisposition syndrome caused by pathogenic germline variants of TP53. Cancer surveillance has noted a significant survival advantage in individuals with LFS; however, little is known about the feasibility, acceptance, and psychosocial effects of such a program.

Methods: Pathogenic TP53 germline variant carriers completed a 7-part questionnaire evaluating sociodemographics, cancer history, surveillance participation, reasons for nonadherence, worries, and distress adapted from the Cancer Worry Scale. Read More

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http://dx.doi.org/10.1002/cncr.33004DOI Listing

Increased vulnerability of clinical research units during the COVID-19 crisis and their protection.

Cancer 2020 Jun 2. Epub 2020 Jun 2.

START Madrid-HM Centro Integral Oncológico Clara Campal (CIOCC) Early Phase Program, HM Sanchinarro University Hospital, Madrid, Spain.

Lay Summary: Currently, the complexity of clinical trial development in oncology is being further complicated by the coronavirus disease 2019 (COVID-19) pandemic, which is reducing the resources needed to comply with protocol-specific procedures while putting patients in units, who are already vulnerable, at increased general risk not only for COVID-19 infection but also with respect to their baseline disease. Individualizing the management of patients while ensuring their safety and adherence to the study protocol, establishing specific staff contingency plans, and maintaining sponsor and contract research organization (CRO) alignment are some of the key issues for maintaining the continuity of cancer patients' investigational treatment and minimizing their infection risk as well as the risk to staff members of the unit, sponsors, and CROs while maintaining the integrity of data quality and compliance with good clinical practice. Read More

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http://dx.doi.org/10.1002/cncr.32980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300769PMC
June 2020
4.889 Impact Factor

Tipifarnib in recurrent, metastatic HRAS-mutant salivary gland cancer.

Cancer 2020 Jun 18. Epub 2020 Jun 18.

Department of Hematology/Oncology, Memorial Sloan Kettering Cancer Center, New York City, New York.

Background: To the authors' knowledge, there are no approved therapies for recurrent, metastatic (R/M) salivary gland carcinoma (SGC), but molecularly targeted therapies warrant ongoing investigation. In the current study, the authors have reported on the efficacy of tipifarnib in patients with aggressive HRAS-mutant, R/M SGC.

Methods: The current prospective, nonrandomized, multicenter, international cohort study involved 8 centers and was conducted from May 2015 to June 2019. Read More

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http://dx.doi.org/10.1002/cncr.33036DOI Listing
June 2020
4.889 Impact Factor

Reduction of diagnostic error: Following cytopathology's lead.

Authors:
Yael K Heher

Cancer Cytopathol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncy.22308DOI Listing

Measures to reduce diagnostic error and improve clinical decision making in thyroid FNA aspiration cytology: A proposed framework.

Cancer Cytopathol 2020 Jun 16. Epub 2020 Jun 16.

SYNLAB Suisse SA, Lausanne, Switzerland.

Thyroid fine-needle aspiration cytology (FNA) and histopathology can be subjective areas of medical diagnosis and subject to different interpretations. On the basis of the authors' personal experience, 12 recommendations with potential to improve clinical decision making, ensure quality, and reduce diagnostic error in thyroid FNAC and histopathology are presented. 1) use a standardized reporting terminology for thyroid FNAC; 2) understand and explain to service users the limitations of cytology and the standardized thyroid FNAC reporting terminology used; 3) the cytopathologist should review all relevant clinical and ultrasound findings, if feasible; 4) include the risk of malignancy in all FNAC reports if feasible; 5) collect data to calculate the local institutional risk of malignancy for FNAC if feasible; 6) accept that nondiagnostic FNAC will include small numbers of carcinomas; 7) use rapid on-site evaluation and/or educational sessions for aspirators if the nondiagnostic aspiration rate is high; 8) know the diagnostic pitfalls of both cytology and histopathology; 9) use special immunohistochemical and molecular techniques that are evidence-based; 10) make use of second opinions, either in-house or interinstitutional; 11) multidisciplinary discussion of cases before surgery or therapy is invaluable; and, finally, 12) manage patient and clinician expectations of thyroid cytology and histopathology. Read More

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http://dx.doi.org/10.1002/cncy.22309DOI Listing

Mental health among nonelderly adult cancer survivors: A national estimate.

Cancer 2020 Jun 15. Epub 2020 Jun 15.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.

Background: This study assessed mental health (MH) outcomes across age groups in a nationally representative US sample of adult cancer survivors.

Methods: The 2015 to 2017 National Survey on Drug Use and Health was used to identify respondents aged 18 to 64 years. The authors compared MH outcomes between respondents with a cancer history and respondents without a cancer history in adjusted analyses controlling for demographics and socioeconomic status. Read More

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http://dx.doi.org/10.1002/cncr.32988DOI Listing

The microbiome in pediatric oncology.

Cancer 2020 Jun 13. Epub 2020 Jun 13.

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

The human microbiome comprises a diverse set of microorganisms, which play a mostly cooperative role in processes such as metabolism and host defense. Next-generation genomic sequencing of bacterial nucleic acids now can contribute a much broader understanding of the diverse organisms composing the microbiome. Emerging evidence has suggested several roles of the microbiome in pediatric hematology/oncology, including susceptibility to infectious diseases, immune response to neoplasia, and contributions to the tumor microenvironment as well as changes to the microbiome from chemotherapy and antibiotics with unclear consequences. Read More

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http://dx.doi.org/10.1002/cncr.33030DOI Listing

Perioperative COX2 and β-adrenergic blockade improves biomarkers of tumor metastasis, immunity, and inflammation in colorectal cancer: A randomized controlled trial.

Cancer 2020 Jun 13. Epub 2020 Jun 13.

Sagol School of Neuroscience and School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.

Background: Preclinical studies have implicated excess release of catecholamines and prostaglandins in the mediation of prometastatic processes during surgical treatment of cancer. In this study, we tested the combined perioperative blockade of these pathways in patients with colorectal cancer (CRC).

Methods: In a randomized, double-blind, placebo-controlled biomarker trial involving 34 patients, the β-blocker propranolol and the COX2-inhibitor etodolac were administered for 20 perioperative days, starting 5 days before surgery. Read More

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http://dx.doi.org/10.1002/cncr.32950DOI Listing

Reducing injury response to surgery with repurposed drugs: An evolving approach to prevention of cancer metastases.

Cancer 2020 Jun 13. Epub 2020 Jun 13.

Morningside Center for Innovative and Affordable Medicine, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1002/cncr.32949DOI Listing

A multicountry assessment in Eurasia: Alignment of physician perspectives on palliative care integration in pediatric oncology with World Health Organization guidelines.

Cancer 2020 Jun 12. Epub 2020 Jun 12.

Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: The World Health Organization (WHO) advocates for early integration of palliative care for all children with life-threatening illness. Provider awareness and misperceptions, however, can impede this imperative. In the Eurasian region, little is known about physician knowledge and perspectives on palliative care. Read More

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http://dx.doi.org/10.1002/cncr.33001DOI Listing

Insulin resistance and breast cancer incidence and mortality in postmenopausal women in the Women's Health Initiative.

Cancer 2020 Jun 12. Epub 2020 Jun 12.

City of Hope National Medical Center, Duarte, California.

Background: Insulin resistance is associated with higher all-cause and cancer-specific mortality in postmenopausal women. However, to the authors' knowledge, information regarding insulin resistance and breast cancer mortality risk is limited. Therefore, the authors examined associations between insulin resistance and breast cancer incidence and mortality in a subsample of Women's Health Initiative participants. Read More

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http://dx.doi.org/10.1002/cncr.33002DOI Listing

Nondiagnostic fine needle aspirates of the pancreas: A root cause analysis.

Cancer Cytopathol 2020 Jun 11. Epub 2020 Jun 11.

Department of Pathology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Background: Fine needle aspiration (FNA) of the pancreas is considered the primary and least invasive diagnostic method in the evaluation of pancreatic lesions. A nondiagnostic sample may trigger repeat FNA or a more invasive diagnostic procedure. The goal of this study was to identify the root causes of nondiagnostic samples. Read More

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http://dx.doi.org/10.1002/cncy.22301DOI Listing

Multicenter phase 2 trial of nintedanib in advanced nonpancreatic neuroendocrine tumors.

Cancer 2020 Jun 11. Epub 2020 Jun 11.

Department of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

Background: Antiangiogenic-targeting agents have low response rates in patients with nonpancreatic neuroendocrine tumors (NETs). Nintedanib is an oral antiangiogenic agent that has inhibitory effects on the fibroblast growth factor receptor, which is highly expressed in NETs. The authors hypothesized that nintedanib would be active in patients with nonpancreatic NETs. Read More

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http://dx.doi.org/10.1002/cncr.32994DOI Listing

Propensity score analysis of the prognostic value of genomic assays for breast cancer in diverse populations using the National Cancer Data Base.

Cancer 2020 Jun 10. Epub 2020 Jun 10.

Section of Hematology and Oncology, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois, USA.

Background: Genomic assays such as Oncotype Dx (ODX) and MammaPrint are used for risk-adapted treatment decisions among patients with early breast cancer. However, to the authors' knowledge, concordance between genomic assays is modest. Using real-world data, the authors performed a comparative analysis of ODX and MammaPrint. Read More

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http://dx.doi.org/10.1002/cncr.32956DOI Listing

If you don't measure it, you can't improve it: Success and shortcomings of genomic assays in early breast cancer.

Cancer 2020 Jun 10. Epub 2020 Jun 10.

Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/cncr.32955DOI Listing

Benefit of double-reading cytology smears as a triage strategy among high-risk human papillomavirus-positive women in Mexico.

Cancer Cytopathol 2020 Jun 10. Epub 2020 Jun 10.

Centro de Investigación en Salud Poblacional. Instituto Nacional de Salud Pública, Cuernavaca, Mexico.

Background: The goal of this study was to determine whether the detection of histologically confirmed cases of cervical high-grade squamous intraepithelial lesions or worse (HSIL+) can be increased by having each liquid-based cytology (LBC) slide read by 2 cytotechnologists as part of routine screening.

Methods: Over 36,212 women aged 30 to 64 years participated in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage (FRIDA) Study in Mexico between 2013 and 2016. For each participant, 2 cervical samples were collected at the same clinic visit, one to test for high-risk human papillomavirus (hrHPV) and the other for LBC, which was used to triage those with a hrHPV positive result. Read More

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http://dx.doi.org/10.1002/cncy.22303DOI Listing

A new guideline from the College of American Pathologists to improve the adequacy of thoracic small specimens for ancillary studies.

Cancer Cytopathol 2020 Jun 10. Epub 2020 Jun 10.

Division of Pathology and Laboratory Medicine, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1002/cncy.22299DOI Listing

Optimizing patient selection for cytoreductive nephrectomy based on outcomes in the contemporary era of systemic therapy.

Cancer 2020 Jun 9. Epub 2020 Jun 9.

Department of Urology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: The management of metastatic renal cell carcinoma (mRCC) has evolved rapidly, and results from the Cancer du Rein Metastatique Nephrectomie et Antiangiogéniques (CARMENA) trial bring into question the utility of cytoreductive nephrectomy (CN). The objective of this study was to examine overall survival (OS) and identify risk factors associated with patients less likely to benefit from CN in the targeted therapy era.

Methods: Patients with mRCC undergoing CN from 2005 to 2017 were identified. Read More

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http://dx.doi.org/10.1002/cncr.32991DOI Listing

Personalizing preoperative risk stratification and refining patient selection for cytoreductive nephrectomy in metastatic renal cell carcinoma.

Authors:
Sarah P Psutka

Cancer 2020 Jun 9. Epub 2020 Jun 9.

Department of Urology, University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1002/cncr.32993DOI Listing

Randomized trial of a hospice video educational tool for patients with advanced cancer and their caregivers.

Cancer 2020 Jun 8. Epub 2020 Jun 8.

Department of Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Background: Patients with advanced cancer and their caregivers have substantial misperceptions regarding hospice, which contributes to its underuse.

Methods: The authors conducted a single-site randomized trial of a video educational tool versus a verbal description of hospice in 150 hospitalized patients with advanced cancer and their caregivers. Patients without a caregiver were eligible. Read More

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http://dx.doi.org/10.1002/cncr.32967DOI Listing

Postoperative circulating tumor cells: An early predictor of extrahepatic metastases in patients with hepatocellular carcinoma undergoing curative surgical resection.

Cancer Cytopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Postoperative extrahepatic metastases (EHM) contribute to a grim outcome in patients with hepatocellular carcinoma (HCC) who are undergoing curative surgical resection. The current study investigated the clinical value of circulating tumor cells (CTCs) in predicting EHM after curative surgery.

Methods: A total of 197 patients with HCC who were undergoing curative surgical resection were assigned to a retrospective training cohort (144 patients) or a prospective validation cohort (53 patients). Read More

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http://dx.doi.org/10.1002/cncy.22304DOI Listing

Reply to Rapid on-site evaluation and the COVID-19 pandemic.

Cancer Cytopathol 2020 Jun 5. Epub 2020 Jun 5.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.

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http://dx.doi.org/10.1002/cncy.22296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300869PMC
June 2020
3.354 Impact Factor

Vaping prevention program targets students.

Authors:
Carrie Printz

Cancer 2020 Jul;126(13):2955

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http://dx.doi.org/10.1002/cncr.33000DOI Listing

Obesity, race, and long-term prostate cancer outcomes.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Urology Section, Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.

Background: The authors previously found that obesity was linked with prostate cancer (PC)-specific mortality (PCSM) among men who underwent radical prostatectomy (RP). Herein, in a larger RP cohort, the authors investigated whether the association between obesity and long-term PC outcomes, including PCSM, differed by race.

Methods: Data from 5929 patients who underwent RP and were in the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed. Read More

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http://dx.doi.org/10.1002/cncr.32906DOI Listing

MEK or ERK inhibition effectively abrogates emergence of acquired osimertinib resistance in the treatment of epidermal growth factor receptor-mutant lung cancers.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia.

Background: The majority of patients with non-small cell lung cancer (NSCLC) harboring activating epidermal growth factor receptor (EGFR) mutations respond well to osimertinib (AZD9291), a third-generation, mutation-selective EGFR inhibitor. The current study focuses on determining whether targeting MEK/ERK signaling prevents or delays the development of acquired resistance to osimertinib.

Methods: Drug effects on cell survival were determined by measuring cell number alterations. Read More

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http://dx.doi.org/10.1002/cncr.32996DOI Listing