4,117,020 results match your criteria Cancer control : journal of the Moffitt Cancer Center[Journal]


Cytotoxic and Anti-inflammatory Terpenoids from the Whole Plant of Vaccinium emarginatum.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.

Two new Δ ursene-type triterpenoid coumaroyl esters (1: and 2: ), one new Δ isopimarane-type diterpenoid glycoside (20: ), and two new irido--lactone-type iridoids (21: and 22: ), together with 17 known pentacyclic triterpenoids (3:  - 19: ), were isolated during the phytochemical investigation of a methanol extract of the whole plant of . Their structures were determined by detailed analysis of standard spectroscopic data (MS, IR, 1D, and 2D NMR) and comparison with data of known analogs. The isolates were evaluated for their cytotoxicity against the PC-3 and Du145 prostate cancer cell lines (as assessed by an MTT cell proliferation assay), as well as for their anti-inflammatory activity via the inhibition of nitric oxide production in lipopolysaccharide-induced murine macrophage RAW 264. Read More

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http://dx.doi.org/10.1055/a-1192-6225DOI Listing

[Consulting Ethics Committees about a Multicenter Observational Study in Germany - A Report on Effort and Costs].

Gesundheitswesen 2020 Jul 9. Epub 2020 Jul 9.

Zertifizierung, Deutsche Krebsgesellschaft eV, Berlin.

Aim Of The Study: Ethics committees (ECs) have an indispensable monitoring and regulatory function in research on human beings. In multicenter observational studies, approvals of several local ECs are often required. The aim of this analysis was to provide an overview of the resources used and the process for consulting ECs about a multicenter observational study in Germany. Read More

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http://dx.doi.org/10.1055/a-1192-4946DOI Listing

Combination of Lorcaserin and GLP-1/glucagon Coagonist Improves Metabolic Dysfunction in Diet Induced-obese Mice.

Drug Res (Stuttg) 2020 Jul 9. Epub 2020 Jul 9.

Zydus Research Centre, Cadila Healthcare Limited, Moraiya, Ahmedabad, India.

Background: Obesity and diabetes are major metabolic disorders that progress to severe morbidity and mortality. Neuroendocrine mechanisms controlling energy balance indicate that combination therapies are needed to sustain weight loss. Lorcaserin was one of the approved therapies for the treatment of obesity, which is recently withdrawn because a safety clinical trial, shows an increased occurrence of cancer. Read More

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http://dx.doi.org/10.1055/a-1201-2700DOI Listing

Healthcare interventions improving and reducing quality of life in children at the end of life: a systematic review.

Pediatr Res 2020 Jul 9. Epub 2020 Jul 9.

End-of-Life Care Research Group, Vrije Universiteit Brussel and Ghent University, Brussels Health Campus-Building K Laarbeeklaan 103, 1090, Brussels, Belgium.

Background: Children with serious illness suffer from symptoms at the end of life that often fail to be relieved. An overview is required of healthcare interventions improving and decreasing quality of life (QOL) for children with serious illness at the end of life.

Methods: A systematic review was performed in five databases, January 2000 to July 2018 without language limit. Read More

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http://dx.doi.org/10.1038/s41390-020-1036-xDOI Listing

Clinicopathological Relevance and Prognostic Value of Androgen Receptor in Mammary Paget's Disease with Underlying Invasive Ductal Carcinoma.

Oncol Res Treat 2020 Jul 9:1-7. Epub 2020 Jul 9.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Mammary Paget's disease (MPD) is a rare cutaneous manifestation. Epidemiologically, more than half of the MPD patients concurrently have underlying invasive ductal carcinoma (MPD-IDC), and their prognosis remains poor despite multimodal treatments of breast cancer have markedly improved patients' survival. Accordingly, it is crucial to seek out novel therapeutic targets of MPD-IDC. Read More

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http://dx.doi.org/10.1159/000507893DOI Listing

Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype.

Pathobiology 2020 Jul 9:1-14. Epub 2020 Jul 9.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, United Kingdom,

Lymphovascular invasion (LVI) is associated with poor outcome in breast cancer (BC); however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex molecular pathways involving not only the interplay with the surrounding microenvironment along with endothelial cells lining the lymphovascular spaces but also changes in the malignant epithelial cells with the acquisition of more invasive and migration abilities. In this review, we focus on the key features that enable tumour cell detachment from the primary niche, their migration and interaction with the surrounding microenvironment as well as the crosstalk with the vascular endothelial cells, which eventually lead to intravasation of tumour cells and LVI. Read More

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http://dx.doi.org/10.1159/000508337DOI Listing
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