4,113,663 results match your criteria Cancer communications London England[Journal]


Predictive performance of ultrasonography-based radiomics for axillary lymph node metastasis in the preoperative evaluation of breast cancer.

Ultrasonography 2020 Apr 1. Epub 2020 Apr 1.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science and Center for Clinical Image Data Science, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to evaluate the predictive performance of ultrasonography (US)-based radiomics for axillary lymph node metastasis and to compare it with that of a clinicopathologic model.

Methods: A total of 496 patients (mean age, 52.5±10. Read More

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http://dx.doi.org/10.14366/usg.20026DOI Listing

Immunotherapy in sinonasal melanoma: treatment patterns and outcomes compared to cutaneous melanoma.

Int Forum Allergy Rhinol 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA.

Background: Although treatment with checkpoint blockade is now accepted as standard of care for cutaneous melanoma, few studies have investigated its role in sinonasal melanoma (SNM). We aimed to evaluate whether immunotherapy was associated with improved survival in SNM and to compare the effect of immunotherapy in metastatic sinonasal and cutaneous melanoma.

Methods: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with sinonasal or cutaneous melanoma between 2012 and 2015 and had complete information regarding immunotherapy status. Read More

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http://dx.doi.org/10.1002/alr.22628DOI Listing

Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155.

IUBMB Life 2020 Jul 4. Epub 2020 Jul 4.

Department of Breast and Thyroid Surgery, Jining No. 1 People's Hospital, Jining, Shandong, China.

Aims: Schizandrin A (SchA) is a type of lignan with biological properties against oxidation, inflammation, and cancer. Here, we aimed to sustain the bioactive properties of SchA in proliferative and motional phenotypes of MDA-MB-231 cells and their molecular mechanism.

Methods: MDA-MB-231 cells were exposed to SchA. Read More

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http://dx.doi.org/10.1002/iub.2329DOI Listing

Association of clinical predictors with recurrence of atrial fibrillation after catheter ablation.

Ann Noninvasive Electrocardiol 2020 Jul 5:e12787. Epub 2020 Jul 5.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Recurrence rate after radiofrequency catheter ablation (RFCA) remains high, and further investigation on predictors of recurrence is needed.

Objects: To identify risk factors of atrial fibrillation (AF) recurrence in patients undergoing RFCA.

Methods: We retrospectively studied 257 patients with AF who underwent RFCA preceded by transthoracic echocardiographic and pulmonary vein CT examination from 2016 to 2019. Read More

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http://dx.doi.org/10.1111/anec.12787DOI Listing

Nuclear staining of claudin-18 is a new immunohistochemical marker for diagnosing intramucosal well-differentiated gastric adenocarcinoma.

Pathol Int 2020 Jul 5. Epub 2020 Jul 5.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Diagnosis of gastric adenocarcinoma using small biopsy samples is occasionally difficult. Various markers have been employed for improving the diagnostic accuracy, but there remains room for improvement. A total of 129 endoscopically biopsied samples were studied, consisting of 104 intramucosal tubular adenocarcinomas, 24 non-cancerous lesions and one cancer sample originally suspected of non-cancer but revised as cancer after immunostaining. Read More

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http://dx.doi.org/10.1111/pin.12978DOI Listing

Early outcomes of Single Port Robotic Radical Prostatectomy.Lessons Learned from The learning curve experience.

BJU Int 2020 Jul 4. Epub 2020 Jul 4.

AdventHealth Global Robotics Institute, Celebration, FL, USA.

Objective: To describe the crucial factors related to the implementation of the da Vinci SP system, and the early outcomes after the introduction of this robot for radical prostatectomy (RARP).

Materials And Methods: We prospectively collected the data from 50 consecutive patients with prostate adenocarcinoma who underwent RARP with this robot. The median follow-up was 53 days. Read More

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http://dx.doi.org/10.1111/bju.15158DOI Listing

Survival Following Cytoreductive Nephrectomy: A Comparison of Existing Prognostic Models.

BJU Int 2020 Jul 4. Epub 2020 Jul 4.

The University of Texas, M.D. Anderson Cancer Center, Department of Urology, USA.

Objective: To validate models currently used to predict metastatic renal cell carcinoma (mRCC) outcomes in a cohort of patients undergoing cytoreductive nephrectomy (CN).

Patients And Methods: Ten renal cell carcinoma (RCC) prognostic models (International Metastatic RCC Database Consortium [IMDC]; Memorial Sloan Kettering Cancer Center [MSKCC]; Culp; Leibovich; University of California at Los Angeles Integrated Staging System [UISS]; Stage, Size, Grade, and Necrosis [SSIGN]; Yaycioglu; Karakiewicz; Cindolo; and Margulis) were chosen based on clinical relevance and use in clinical trial design. Model validation was performed using patients who underwent CN at a single institution between 2005 and 2017 and model discrimination (ability to select patients at risk of death) was assessed. Read More

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http://dx.doi.org/10.1111/bju.15160DOI Listing

Regarding: Cancer Rehabilitation Medical Knowledge for Physiatry Residents- Literature Subtopic Analysis and Synthesis into Key Domains.

PM R 2020 Jul 5. Epub 2020 Jul 5.

Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792.

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http://dx.doi.org/10.1002/pmrj.12447DOI Listing

Severe acute exacerbation of HCV infection in cancer patients who undergo chemotherapy: some issues.

J Viral Hepat 2020 Jul 5. Epub 2020 Jul 5.

Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

We read with interest the manuscript published by Li et al. reporting the severe acute exacerbation of hepatitis C virus (HCV) infection in cancer patients undergoing chemotherapy without anti-viral prophylaxis in their retrospective study. The authors concluded that HCV infection increases the risk of acute severe liver injury in cancer patients undergoing chemotherapy. Read More

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http://dx.doi.org/10.1111/jvh.13358DOI Listing

Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.

FASEB J 2020 Jul 5. Epub 2020 Jul 5.

Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

The majority of anti-cancer therapies target the proliferating tumor cells, while the tumor stroma, principally unaffected, survives, and provide a niche for surviving tumor cells. Combining tumor cell and stroma-targeting therapies thus have a potential to improve patient outcome. The neuroblastoma stroma contains cancer-associated fibroblasts expressing microsomal prostaglandin E synthase-1 (mPGES-1). Read More

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http://dx.doi.org/10.1096/fj.202000684RDOI Listing

Special type breast carcinoma: Sebaceous carcinoma of the breast; A case report and review of literature.

Breast J 2020 Jul 4. Epub 2020 Jul 4.

General Surgery Department, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon.

Sebaceous carcinoma of the breast is an extremely rare tumor. To the best of our knowledge only 15 cases have been reported in literature. Herein, we report a case of sebaceous carcinoma of the breast and describe the histopathologic features of sebaceous carcinoma of the breast in an elderly female. Read More

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http://dx.doi.org/10.1111/tbj.13963DOI Listing

EpigenCentral: Portal for DNA methylation data analysis and classification in rare diseases.

Hum Mutat 2020 Jul 5. Epub 2020 Jul 5.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.

Epigenetic processes play a key role in regulating gene expression. Genetic variants that disrupt chromatin-modifying proteins are associated with a broad range of diseases, some of which have specific epigenetic patterns, such as aberrant DNA methylation, that may be used as disease biomarkers. While much of the epigenetic research has focused on cancer, there is a paucity of resources devoted to neurodevelopmental disorders, which include autism spectrum disorder and many rare, clinically overlapping syndromes. Read More

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http://dx.doi.org/10.1002/humu.24076DOI Listing

Variant effect on splicing regulatory elements, branchpoint usage, and pseudoexonization: strategies to enhance bioinformatic prediction using hereditary cancer genes as exemplars.

Hum Mutat 2020 Jul 5. Epub 2020 Jul 5.

Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.

It is possible to estimate the prior probability of pathogenicity for germline disease gene variants based on bioinformatic prediction of variant effect/s. However, routinely used approaches have likely led to the underestimation and underreporting of variants located outside donor and acceptor splice site motifs that affect mRNA processing. This review presents information about hereditary cancer gene germline variants, outside native splice sites, with experimentally validated splicing effects. Read More

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http://dx.doi.org/10.1002/humu.24074DOI Listing

A case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse Large B-cell Lymhpoma with immature features or B-cell Lymhpoblastic Lymphoma?

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Oncology and Hematology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Primary cutaneous B-cell lymphomas are a heterogeneous group of lymphoid neoplasms primarily occurring in the skin. Although most cases are represented by primary cutaneous follicle center cell lymphoma, primary cutaneous marginal zone lymphoma and leg-type diffuse large B-cell lymphoma, other diffuse large B-cell lymphomas and B-cell lymphoblastic lymphoma may rarely present primarily in the skin. In this setting, the presence of histopathologic and immunohistochemical features of cellular immaturity is exceedingly rare and may represent a diagnostic challenge. Read More

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http://dx.doi.org/10.1111/cup.13795DOI Listing

Safe, Mild Ultraviolet-B Exposure: An Essential Human Requirement for Vitamin D and Other Vital Bodily Parameter Adequacy: A Review.

Authors:
J L M Hawk

Photodermatol Photoimmunol Photomed 2020 Jul 5. Epub 2020 Jul 5.

Emeritus Professor of Dermatological Photobiology and Former Head, Photobiology Department, St John's Institute of Dermatology, King's College London, UK.

The enigma of skin sunburning, skin ageing and skin cancer and essential vitamin D production both resulting from solar ultraviolet-B (280-315 nanometres, nm) (UVB) exposure has long puzzled photobiologists. Advice to patients by non-photobiological clinicians is now often to sunbathe to acquire vitamin D adequacy. However, modern work shows only mild UVB exposure is needed to maintain satisfactory levels, which have been demonstrated as very similar in summer and winter from about 25° to 70° north. Read More

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http://dx.doi.org/10.1111/phpp.12584DOI Listing

Performing gynecologic cancer surgery during the COVID-19 pandemic in Turkey: A multicenter retrospective observational study.

Int J Gynaecol Obstet 2020 Jul 4. Epub 2020 Jul 4.

Medeniyet University, Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Istanbul, Turkey.

Objective: To report the perioperative outcomes of 200 patients with gynecologic cancer who underwent surgery during the Novel Coronavirus Disease (COVID-19) pandemic and the safety of surgical approach.

Methods: Data of patients operated between March 10 and May 20, 2020, were collected retrospectively. Data were statistically analyzed using IBM Statistical Package for the Social Sciences (SPSS) Statistics for Windows v. Read More

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http://dx.doi.org/10.1002/ijgo.13296DOI Listing

Surgical versus Nonsurgical Management of Postmastectomy Lymphedema: A Prospective Quality of Life Investigation.

J Reconstr Microsurg 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

Background:  Postmastectomy secondary lymphedema can cause substantial morbidity. However, few studies have investigated longitudinal quality of life (QoL) outcomes in patients with postmastectomy lymphedema, especially with regard to surgical versus nonoperative management. This study prospectively investigated QoL in surgically versus nonsurgically managed patients with postmastectomy upper extremity lymphedema. Read More

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http://dx.doi.org/10.1055/s-0040-1713667DOI Listing

Role of the bone microenvironment in bone metastasis of malignant tumors - therapeutic implications.

Authors:
Xiaoting Ma Jing Yu

Cell Oncol (Dordr) 2020 Jul 4. Epub 2020 Jul 4.

Cancer Center, Beijing Friendship Hospital, Capital Medical University, No.95 Yong An Road, Xi Cheng District, Beijing, 100050, China.

Background: Bone is one of the most common sites for solid tumor metastasis. Bone metastasis of a malignant tumor seriously affects the quality of life and the overall survival of patients. Evidence has suggested that bone provides a favorable microenvironment that enables disseminated tumor cells to home, proliferate and colonize, leading to the formation of metastases. Read More

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http://dx.doi.org/10.1007/s13402-020-00512-wDOI Listing

Association of genetic polymorphism of BCL-2 (rs2279115) with susceptibility to HCV-related hepatocellular carcinoma.

Immunol Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Hepatitis C virus (HCV) infection is the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). B cell lymphoma-2 (BCL-2) prevents apoptosis, and its overexpression could promote cancer cell survival. The purpose of this study is to evaluate the association of Bcl-2 gene polymorphism (rs2279115) and HCV-related HCC susceptibility. Read More

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http://dx.doi.org/10.1007/s12026-020-09143-7DOI Listing

Secondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation.

Mol Biol Rep 2020 Jul 4. Epub 2020 Jul 4.

Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, Nizwa, PC, 616, Oman.

Among medicinal plants, Acridocarpus orientalis (AO) possesses a remarkable anti-cancer potential, possibly because of its anti-oxidant property. In this study, the leaf and stem extracts from AO were assessed to find the bioactive compound with selective anti-cancer properties. The MTT viability and live and dead assays revealed that around 80% and 98% of 4T1 cells survival were declined after 48 h incubation with leaf and stem extracts, respectively. Read More

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http://dx.doi.org/10.1007/s11033-020-05632-yDOI Listing

Intraoperative Pathologic Margin Analysis and Re-Excision to Minimize Reoperation for Patients Undergoing Breast-Conserving Surgery.

Ann Surg Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Reoperation rates following breast-conserving surgery (BCS) range from 10 to 40%, with marked surgeon and institutional variation.

Objective: The aim of this study was to identify factors associated with intraoperative margin re-excision, evaluate for any differences in local recurrence based on margin re-excision and determine reoperation rates with use of intraoperative margin analysis.

Patients And Methods: We analyzed consecutive patients with ductal carcinoma in situ (DCIS) or invasive breast cancer who underwent BCS at our institution between 1 January 2005 and 31 December 2016. Read More

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http://dx.doi.org/10.1245/s10434-020-08785-zDOI Listing

The MelFo Study UK: Effects of a Reduced-Frequency, Stage-Adjusted Follow-Up Schedule for Cutaneous Melanoma 1B to 2C Patients After 3-Years.

Ann Surg Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Evidence-based guidelines for follow-up treatment of American Joint Committee on Cancer (AJCC) stages 1B to 2C melanoma patients are lacking. The MELanoma FOllow-up study is an international phase 3 randomized trial, and the 3-year interim data were recently reported from the Netherlands. The study was undertaken concurrently with a British cohort for comparison and validation of the Dutch study. Read More

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http://dx.doi.org/10.1245/s10434-020-08758-2DOI Listing

Photodynamic treatment with purpurin 18 effectively inhibits triple negative breast cancer by inducing cell apoptosis.

Lasers Med Sci 2020 Jul 5. Epub 2020 Jul 5.

School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

This study aims to evaluate the photodynamic efficacy of purpurin 18 (pu-18) on triple negative breast cancer both in vitro and in vivo. Two states of 4T1 cells, 2D culture and 3D spheroids, were used to evaluate the photodynamic action of pu-18 in vitro. The in vitro study results indicated that for the 4T1 2D cell culture, the photodynamic therapy (PDT) treatment showed significant photocytotoxicity at low pu-18 concentrations following light irradiation. Read More

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http://dx.doi.org/10.1007/s10103-020-03035-wDOI Listing

Therapeutic approach and management algorithms in medication-related osteonecrosis of the jaw (MONJ): recommendations of a multidisciplinary group of experts.

Arch Osteoporos 2020 Jul 4;15(1):101. Epub 2020 Jul 4.

, Bogota, Colombia.

Background: The justification for this consensus is the absence of local protocols on Medication-Related Osteonecrosis of the Jaws (MONJ), for prevention, evaluation, and treatment, involving physicians and dentists, leading to suspension of antiresorptive treatments, despite their benefit in the prevention of fragility fractures (40-70%). These fractures cause disability and mortality (80% and 20-30%, respectively), as opposed to the low risk associated with MONJ in osteoporotic (0.01-0. Read More

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http://dx.doi.org/10.1007/s11657-020-00761-0DOI Listing

Treatment of MOG antibody associated disorders: results of an international survey.

J Neurol 2020 Jul 4. Epub 2020 Jul 4.

Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Introduction: While monophasic and relapsing forms of myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are increasingly diagnosed world-wide, consensus on management is yet to be developed.

Objective: To survey the current global clinical practice of clinicians treating MOGAD.

Method: Neurologists worldwide with expertise in treating MOGAD participated in an online survey (February-April 2019). Read More

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http://dx.doi.org/10.1007/s00415-020-10026-yDOI Listing

RP11-323N12.5 promotes the malignancy and immunosuppression of human gastric cancer by increasing YAP1 transcription.

Gastric Cancer 2020 Jul 4. Epub 2020 Jul 4.

Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210093, Jiangsu, People's Republic of China.

Background: YAP1 is a core protein of the Hippo signaling pathway and is associated with malignancy and immunosuppression. In the present study, we discovered a novel lncRNA, RP11-323N12.5, with tumor promotion and immunosuppression activities through enhancing transcription of YAP1. Read More

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http://dx.doi.org/10.1007/s10120-020-01099-9DOI Listing

Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer.

Gastric Cancer 2020 Jul 4. Epub 2020 Jul 4.

Center for Gastric Cancer, National Cancer Center, Goyang, Korea.

Background: This study aimed to investigate risk factors for lymph node (LN) or distant metastasis after non-curative endoscopic resection (ER) of undifferentiated-type early gastric cancer (EGC).

Methods: Of 1124 patients who underwent ER for undifferentiated-type gastric cancer at 18 tertiary hospitals across six geographic areas in Korea between 2005 and 2014, 634 with non-curative ER beyond the expanded criteria were retrospectively enrolled. According to the treatment after ER, patients were divided into additional surgery (n = 270) and follow-up (n = 364) groups. Read More

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http://dx.doi.org/10.1007/s10120-020-01103-2DOI Listing

The Controlling Nutritional Status (CONUT) Score as a prognostic factor for obstructive colorectal cancer patients received stenting as a bridge to curative surgery.

Surg Today 2020 Jul 4. Epub 2020 Jul 4.

Departments of Gastroenterological Surgery, Sendai City Medical Center Sendai Open Hospital, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.

Purpose: The Controlling Nutritional Status (CONUT) Score, originally developed as a nutritional screening tool, is a cumulative score calculated from the serum albumin level, total cholesterol level, and total lymphocyte count. Previous studies have demonstrated that the score has significant prognostic value in various malignancies. We investigated the relationship between the CONUT score and long-term survival in obstructive colorectal cancer (OCRC) patients who underwent self-expandable metallic colonic stent placement and subsequently received curative surgery. Read More

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http://dx.doi.org/10.1007/s00595-020-02066-8DOI Listing

A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment.

Clin Transl Oncol 2020 Jul 4. Epub 2020 Jul 4.

Radiology Department, Ramón y Cajal University Hospital, Madrid, Spain.

The implementation of immunotherapy has radically changed the treatment of oncological patients. Currently, immunotherapy is indicated in the treatment of patients with head and neck tumors, melanoma, lung cancer, bladder tumors, colon cancer, cervical cancer, breast cancer, Merkel cell carcinoma, liver cancer, leukemia and lymphomas. However, its efficacy is restricted to a limited number of cases. Read More

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http://dx.doi.org/10.1007/s12094-020-02442-3DOI Listing

Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α.

Genes Genomics 2020 Jul 4. Epub 2020 Jul 4.

Department of Nutrition, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, 050000, Hebei, China.

Background: The main therapies for cancer often results in many side effects and drug resistance. Gamma linolenic acid (GLA) is a kind of natural reagent with negligible cytotoxicity.

Objective: This work aims at detecting whether GLA possesses anti-cancer activity in NSCLC cells and elucidating the potential molecular mechanism. Read More

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http://dx.doi.org/10.1007/s13258-020-00961-5DOI Listing

Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial.

J Cancer Res Clin Oncol 2020 Jul 4. Epub 2020 Jul 4.

Shanghai East Hospital, Tongji University School of Medicine, No. 150 Ji-Mo Rd., Shanghai, 200120, China.

Purpose: Patients with DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) cancers are prone to response to programmed cell death-1 (PD-1) checkpoint inhibitors. Therefore, we explored the efficacy and safety of a PD-1 checkpoint inhibitor camrelizumab in advanced or metastatic solid tumour with dMMR/MSI-H.

Methods: Patients with dMMR/MSI-H advanced or metastatic solid tumours who had received at least one line of prior systemic chemotherapy were recruited. Read More

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http://dx.doi.org/10.1007/s00432-020-03251-5DOI Listing

Detection of sub-centimeter lesions using digital TOF-PET/CT system combined with Bayesian penalized likelihood reconstruction algorithm.

Ann Nucl Med 2020 Jul 4. Epub 2020 Jul 4.

Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Objective: Many advances in PET/CT technology can potentially improve image quality and the ability to detect small lesions. A new digital TOF-PET/CT scanner based on silicon photomultipliers (SiPM) integrated with a Bayesian penalized likelihood (BPL) PET reconstruction algorithm (Q.Clear; GE Healthcare) has been introduced into clinical practice. Read More

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http://dx.doi.org/10.1007/s12149-020-01500-8DOI Listing

Prediction formula for predicted diffusion capacity of lung for carbon monoxide in pulmonary surgery.

Gen Thorac Cardiovasc Surg 2020 Jul 4. Epub 2020 Jul 4.

Department of Thoracic Surgery, Iwate Medical University, 2-1-1 Idai-dori, Yahaba, Shiwa, Iwate, 028-3695, Japan.

Objectives: Diffusion capacity of the lung for carbon monoxide (D) is a useful value for perioperative risk assessment of non-small cell lung cancer (NSCLC). The percentage of the predicted D (%D: D/predicted D × 100) is often evaluated by setting cutoff values as in the clinical field, but several formulae are available for calculating the predicted D, and the %D thus varies depending on the formula used to predict D. We examined differences in %D calculated using several commonly used prediction formulae. Read More

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http://dx.doi.org/10.1007/s11748-020-01424-0DOI Listing

Extrahepatic metabolism of ibrutinib.

Invest New Drugs 2020 Jul 4. Epub 2020 Jul 4.

Division of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.

Ibrutinib is a first-in-class Bruton's kinase inhibitor used in the treatment of multiple lymphomas. In addition to CYP3A4-mediated metabolism, glutathione conjugation can be observed. Subsequently, metabolism of the conjugates and finally their excretion in feces and urine occurs. Read More

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http://dx.doi.org/10.1007/s10637-020-00970-xDOI Listing

The role of MRI pelvimetry in predicting technical difficulty and outcomes of open and minimally invasive total mesorectal excision: a systematic review.

Tech Coloproctol 2020 Jul 4. Epub 2020 Jul 4.

Surgical Outcomes Research Centre (SOuRCe), Sydney, Australia.

Background: The difficulty of performing total mesorectal excision (TME) for rectal cancer partly relies on the surgeon's subjective assessment of the individual patient's pelvic anatomy and tumour characteristics, which generally influences the choice of platform used (open, laparoscopic, robotic or trans-anal surgery). Recent studies have found associations between several anatomical pelvic measurements and surgical difficulty. The aim of this study was to systematically review existing data reporting the use of magnetic resonance imaging (MRI)-based pelvic measurements to predict technical difficulty and outcomes of TME, and determine whether pelvimetry could optimise patient-specific selection of a particular surgical approach. Read More

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http://dx.doi.org/10.1007/s10151-020-02274-xDOI Listing

Role of linoleic acid-derived oxylipins in cancer.

Cancer Metastasis Rev 2020 Jul 4. Epub 2020 Jul 4.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Building 101, Room A214, Research Triangle Park, Durham, NC, 27709, USA.

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http://dx.doi.org/10.1007/s10555-020-09904-8DOI Listing

Translating Dysphagia Evidence into Practice While Avoiding Pitfalls: Assessing Bias Risk in Tracheostomy Literature.

Dysphagia 2020 Jul 4. Epub 2020 Jul 4.

School of Audiology and Speech Sciences, University of British Columbia, 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

Critically ill patients who require a tracheostomy often have dysphagia. Widespread practice guidelines have yet to be developed regarding the acute assessment and management of dysphagia in patients with tracheostomy. In order for clinicians to base their practice on the best available evidence, they must first assess the applicable literature and determine its quality. Read More

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http://dx.doi.org/10.1007/s00455-020-10151-wDOI Listing

Transdermal versus oral granisetron in controlling chemotherapy-induced nausea and vomiting: a meta-analysis.

Support Care Cancer 2020 Jul 4. Epub 2020 Jul 4.

Division of Medical Oncology, Department of Medicine, University of the Philippines - Philippine General Hospital, Taft Avenue, Ermita, Manila, Philippines.

Purpose: To compare the efficacy of transdermal granisetron versus oral granisetron in controlling chemotherapy-induced nausea and vomiting (CINV) in patients with cancer METHODS: Data sources were CENTRAL, MEDLINE, EMBASE, Clinicaltrials.gov , and Google Scholar. Inclusion criteria included randomized controlled trials comparing transdermal versus oral granisetron in patients with CINV. Read More

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http://dx.doi.org/10.1007/s00520-020-05611-wDOI Listing

Feasibility and acceptability of a telephone-based chaplaincy intervention in a large, outpatient oncology center.

Support Care Cancer 2020 Jul 4. Epub 2020 Jul 4.

Haslinger Family Pediatric Palliative Care Center, Rebecca D. Considine Research Institute, Akron Children's Hospital, Akron, OH, USA.

Purpose: Telechaplaincy (the use of telecommunications and virtual technology to deliver spiritual and religious care by healthcare chaplains or other religious/spiritual leaders) is a relatively novel intervention that has increasingly been used in recent years, and especially during COVID-19. Telephone-based chaplaincy is one mode of telechaplaincy. The purpose of this study was to (1) describe telephone-based chaplaincy interventions delivered as the first point of contact to patients who screen positive for religious/spiritual concern(s) using an electronic data system, and (2) assess the feasibility and acceptability of delivering interventions in an outpatient cancer institute using this methodology. Read More

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http://dx.doi.org/10.1007/s00520-020-05598-4DOI Listing

Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results.

Eur Arch Otorhinolaryngol 2020 Jul 4. Epub 2020 Jul 4.

Department of Medical Biophysics and Informatics, 3rd Faculty of Medicine, Charles University, Praha 10 Ruská 87, 100 00, Prague, Czech Republic.

Objectives:  Patients with nasopharyngeal cancer are candidates for proton radiotherapy due to large and comprehensive target volumes, and the necessity for sparing of healthy tissues. The aim of this work is to evaluate treatment outcome and toxicity profile of patients treated with proton pencil-beam scanning radiotherapy.

Materials And Methods:  Between Jan 2013 and June 2018, 40 patients were treated for nasopharyngeal cancer (NPC) with IMPT (proton radiotherapy with modulated intensity). Read More

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http://dx.doi.org/10.1007/s00405-020-06175-5DOI Listing

The impact of atrial fibrillation on outcomes in patients undergoing radical prostatectomy.

World J Urol 2020 Jul 4. Epub 2020 Jul 4.

Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dongdan Dahua Road, Dongcheng District, Beijing, 100730, China.

Purpose: To assess the role of atrial fibrillation (AF) on complicating inpatient outcomes of radical prostatectomy (RP).

Materials And Methods: We identified patients treated with RP during 2012-2014 within National Inpatient Sample (NIS) database. Length of stay, cost of hospitalization, and in-hospital complications were compared between patients with or without diagnosis of AF. Read More

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http://dx.doi.org/10.1007/s00345-020-03337-2DOI Listing

Bone microstructure of adult patients with non-surgical hypoparathyroidism assessed by high-resolution peripheral quantitative computed tomography.

Osteoporos Int 2020 Jul 4. Epub 2020 Jul 4.

Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Shuaifuyuan No.1, Dongcheng District, Beijing, 100730, China.

There is limited evidence regarding changes in bone microstructure in patients with hypoparathyroidism. In the current study, we used a non-invasive technique to assess bone structure in hypoparathyroidism patients and discovered site-specific changes which were mainly influenced by age and menstrual status. Such changes were more prominent in the trabeculae as well as in non-surgical as opposed to post-surgical patients. Read More

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http://dx.doi.org/10.1007/s00198-020-05506-wDOI Listing

Population pharmacokinetics-pharmacodynamics of sunitinib in pediatric patients with solid tumors.

Cancer Chemother Pharmacol 2020 Jul 4. Epub 2020 Jul 4.

Pfizer Global Product Development, 10646 Science Center Drive, CB10, La Jolla, CA, 92121, USA.

Purpose: The safety profile of sunitinib in children, including the impact of sunitinib exposure on safety endpoints, was assessed using population pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) models.

Methods: Data were from two clinical studies in 59 children with solid tumors (age range 2-21 years, 28 male/31 female, body weight range 16.2-100 kg, body surface are [BSA] range 0. Read More

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http://dx.doi.org/10.1007/s00280-020-04106-zDOI Listing

Differential immune microenvironmental features of microsatellite-unstable colorectal cancers according to Fusobacterium nucleatum status.

Cancer Immunol Immunother 2020 Jul 4. Epub 2020 Jul 4.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

It has been suggested that Fusobacterium nucleatum (Fn) may differentially impact tumor immune responses according to microsatellite instability (MSI) status in colorectal cancers (CRCs). We aimed to reveal the detailed relationship between intratumoral Fn and immune microenvironmental features in MSI-high CRCs. A total of 126 MSI-high CRCs were subjected to analyses for intratumoral Fn DNA load using quantitative PCR and for densities of tumor-infiltrating immune cells, including CD3 T cells, CD4 T cells, CD8 T cells, FoxP3 T cells, CD68 macrophages, CD163 macrophages, and CD177 neutrophils, at invasive margin (IM) and center of tumor (CT) areas using computational image analysis of immunohistochemistry. Read More

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http://dx.doi.org/10.1007/s00262-020-02657-xDOI Listing

Potent anti-myeloma efficacy of dendritic cell therapy in combination with pomalidomide and programmed death-ligand 1 blockade in a preclinical model of multiple myeloma.

Cancer Immunol Immunother 2020 Jul 4. Epub 2020 Jul 4.

Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, Republic of Korea.

Dendritic cell (DC)-based vaccines are recognized as a promising immunotherapeutic strategy against cancer; however, the efficacy of immunotherapy with DCs is controlled via immune checkpoints, such as programmed death-ligand 1 (PD-L1). PD-L1 expressed on DC and tumor cells binds to programmed death-1 (PD-1) receptors on the activated T cells, which leads to the inhibition of cytotoxic T cells. Blocking of PD-L1 on DC may lead to improve the efficacy of DC therapy for cancer. Read More

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http://dx.doi.org/10.1007/s00262-020-02654-0DOI Listing

Acceptability of online sun exposure awareness-raising interventions among young Australian women: an exploratory mixed-methods study.

Health Promot Int 2020 Jul 5. Epub 2020 Jul 5.

Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia 5001, Australia.

Melanoma is the most common cancer among young Australians. Despite school-based programs such as 'Sun Smart' leading to increased knowledge among children of the harmful effects of sun exposure, many young adults continue to desire a darker skin tone because of a general perception among their peers that tanned skin is attractive. This 'tanned-ideal' may be challenged through exposure to material posted on social media. Read More

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http://dx.doi.org/10.1093/heapro/daaa048DOI Listing

Healthcare Utilization of Menthol and Non-menthol Cigarette Smokers.

Nicotine Tob Res 2020 Jul 5. Epub 2020 Jul 5.

Institute for Health & Aging, School of Nursing, University of California, San Francisco, San Francisco, CA, USA.

Objective: To study the association between healthcare utilization and menthol cigarette use and whether the association differed between African American (AA) and non-African American (non-AA) smokers.

Methods: We analyzed the three most recent 2005, 2010, and 2015 National Health Interview Survey Cancer Control Supplements. After incorporating propensity score weights adjusting for observed differences between menthol and non-menthol users, we estimated Zero-Inflated Poisson models on hospital nights, emergency department (ED) visits, doctor visits, and home visits as a function of menthol use status and other covariates separately for current cigarette smokers and recent quitters (former smokers quitting cigarette smoking≤4 years). Read More

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http://dx.doi.org/10.1093/ntr/ntaa122DOI Listing

Synaptic Input to Brain Tumors: Clinical Implications.

Neuro Oncol 2020 Jul 5. Epub 2020 Jul 5.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF, Heidelberg.

The recent discovery of synaptic connections between neurons and brain tumor cells fundamentally challenges our understanding of gliomas and brain metastases, and shows how these tumors can integrate into complex neuronal circuits. Here, we provide an overview on glutamatergic neuron-to-brain tumor synaptic communication (NBTSC) and explore novel therapeutic avenues. First, we summarize current concepts of direct synaptic interactions between presynaptic neurons and postsynaptic glioma cells, and indirect perisynaptic input to metastatic breast cancer cells. Read More

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http://dx.doi.org/10.1093/neuonc/noaa158DOI Listing

Uniportal video-assisted thoracoscopic carinal resections: technical aspects and outcomes.

Eur J Cardiothorac Surg 2020 Jul 5. Epub 2020 Jul 5.

Department of Thoracic Surgery, Regional Clinic Hospital, Tyumen, Russia.

Objectives: Important benefits in uniportal video-assisted thoracoscopic surgery (VATS) for lung cancer have recently been achieved. However, the use of this technique for complex sleeve procedures is limited. We describe the technical aspects of and patient outcomes following carinal resections using uniportal VATS. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa120DOI Listing
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