1,785,947 results match your criteria Cancer causes & control : CCC[Journal]


Bone microstructure of adult patients with non-surgical hypoparathyroidism assessed by high-resolution peripheral quantitative computed tomography.

Osteoporos Int 2020 Jul 4. Epub 2020 Jul 4.

Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Shuaifuyuan No.1, Dongcheng District, Beijing, 100730, China.

There is limited evidence regarding changes in bone microstructure in patients with hypoparathyroidism. In the current study, we used a non-invasive technique to assess bone structure in hypoparathyroidism patients and discovered site-specific changes which were mainly influenced by age and menstrual status. Such changes were more prominent in the trabeculae as well as in non-surgical as opposed to post-surgical patients. Read More

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http://dx.doi.org/10.1007/s00198-020-05506-wDOI Listing

Modeling the time-related fluctuations of AFP and PIVKA-II serum levels in patients with cirrhosis undergoing surveillance for hepatocellular carcinoma.

Cancer Biomark 2020 Jul 3. Epub 2020 Jul 3.

Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Center of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, Pisa, Italy.

Background: The time-related variability of HCC biomarkers has not been investigated so far.

Objective: To assess the changes of alpha-fetoprotein (AFP) and protein induced by vitamin-K absence/antagonist-II (PIVKA-II) in patients with HCC (HCC+) as compared to patients without HCC (HCC-).

Methods: AFP and PIVKA-II were measured by a single laboratory using an automated chemiluminescent-enzyme-immunoassay (Fujirebio Inc. Read More

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http://dx.doi.org/10.3233/CBM-190118DOI Listing

"Sushi roll" technique for precise total tongue functional reconstruction using a pre-sutured femoral anterolateral myocutaneous.

Oral Oncol 2020 Jul 2;110:104866. Epub 2020 Jul 2.

Discipline of Oral & Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Objectives: Reconstruction of the total tongue after cancer resection remains one of the challenges in head and neck surgery. Inadequate reconstruction after subtotal or total glossectomy defects leads to poor quality of life. The aim of this study was to explore an economical, practical and effective flap design for functional tongue reconstruction. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104866DOI Listing

Scalp cooling to prevent chemotherapy-induced alopecia.

An Bras Dermatol 2020 Jun 16. Epub 2020 Jun 16.

R & D Department, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.

Chemotherapy-induced alopecia causes an important impact on cancer patients and its risk of persistence is currently a considerable issue in cancer survivors. Of the various interventions proposed for the prevention of chemotherapy-induced alopecia, scalp cooling has emerged as an effective and safe strategy. This paper aims to provide an overview on scalp cooling and chemotherapy-induced alopecia prevention. Read More

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http://dx.doi.org/10.1016/j.abd.2020.03.005DOI Listing

HSP27 regulates viability and migration of cancer cell lines following irradiation.

J Proteomics 2020 Jul 1:103886. Epub 2020 Jul 1.

Department of Otorhinolaryngology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Despite improvements of radiotherapy and better outcomes of cancer patients resistances still limit the therapeutic success. The combined treatment of tumors by the use of irradiation as well as targeted therapies is a promising approach. By the use of a proteomic screening of lung and head and neck cancer cell lines we identified the heat shock protein HSP27 as a potential target protein for a combined treatment strategy. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103886DOI Listing

Perspectives of Afghan refugee mothers on the experience of caring for a child with cancer: a qualitative analysis.

East Mediterr Health J 2020 Jun 24;26(6):680-686. Epub 2020 Jun 24.

School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Background: Cancer in children causes many challenges for the family. When a refugee family experiences it, its impacts may be different and more specific considerations for care may be needed.

Aims: This study aimed to explore the experiences of Afghan mothers living in the Islamic Republic of Iran who had a child with cancer. Read More

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http://dx.doi.org/10.26719/emhj.19.055DOI Listing

Cultivated areas and rural workers' behavior are responsible for the increase in agricultural intoxications in Brazil? Are these factors associated?

Environ Sci Pollut Res Int 2020 Jul 3. Epub 2020 Jul 3.

Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Mutagênese, Estrada do Campus, s/n, Universidade Federal de Goiás, Instituto de Ciências Biológicas, ICB I - Sala 105, Bairro: Campus Universitário, Goiânia, GO, CEP: 74690-900, Brazil.

In Brazil, the increased use of pesticides has caused several consequences such as mortality of non-target species, contamination of aquatic environments, and changes in biodiversity. Regarding humans, such products could increase the cases of poisoning, the number of different types of cancer, and also neurodegenerative and autoimmune diseases, especially in workers who occupationally handle pesticides. Therefore, this study aimed to evaluate the number of agricultural poisonings from 2007 to 2017 and if there is a correlation between harvested areas, and to analyze the possible factors that contribute to poisonings. Read More

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http://dx.doi.org/10.1007/s11356-020-09988-3DOI Listing

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.

Nat Commun 2020 Jul 3;11(1):3353. Epub 2020 Jul 3.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. Read More

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http://dx.doi.org/10.1038/s41467-020-16483-3DOI Listing

Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation.

Commun Biol 2020 Jul 3;3(1):349. Epub 2020 Jul 3.

Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

Angiogenesis is required for tissue repair; but abnormal angiogenesis or neovascularization (NV) causes diseases in the eye. The avascular status in the cornea is a prerequisite for corneal clarity and thought to be maintained by the equilibrium between proangiogenic and antiangiogenic factors that controls proliferation and migration of vascular endothelial cells (ECs) sprouting from the pericorneal plexus. VEGF is the most important intrinsic factor for angiogenesis; anti-VEGF therapies are available for treating ocular NV. Read More

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http://dx.doi.org/10.1038/s42003-020-1069-zDOI Listing

Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency.

Sci Rep 2020 Jul 3;10(1):10985. Epub 2020 Jul 3.

Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.

Isolated hypogonadotropic hypogonadism (IHH), combined pituitary hormone deficiency (CPHD), and septo-optic dysplasia (SOD) constitute a disease spectrum whose etiology remains largely unknown. This study aimed to clarify whether mutations in SMCHD1, an epigenetic regulator gene, might underlie this disease spectrum. SMCHD1 is a causative gene for Bosma arhinia microphthalmia syndrome characterized by arhinia, microphthalmia and IHH. Read More

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http://dx.doi.org/10.1038/s41598-020-67715-xDOI Listing

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

Nat Commun 2020 Jul 3;11(1):3355. Epub 2020 Jul 3.

Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA.

Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism underpinning their divergent genomic methylation activities. Read More

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http://dx.doi.org/10.1038/s41467-020-17109-4DOI Listing

Trends and predictors in all-cause and cause-specific mortality in diabetic and reference populations during 21 years of follow-up.

J Epidemiol Community Health 2020 Jul 3. Epub 2020 Jul 3.

Public Health, University of Helsinki, Helsinki, Finland

Background: Patients with diabetes mellitus (DM) have a markedly higher overall mortality from coronary heart disease (CHD), as well as many other causes of death like cancer. Since diabetes is a multisystem disease, this fact together with the increased lifespan among individuals with diabetes may also lead to the emergence of other diabetes-related complications and ultimately to diversification of the causes of death.

Methods: The study population of this observational historic cohort study consisted of subjects with DM, who had purchased for at least one insulin prescription and/or one oral antidiabetic between January 1, 1997 and December 31, 2010 (N=199 354), and a reference population matched by age, sex and hospital district (N=199 354). Read More

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http://dx.doi.org/10.1136/jech-2019-213602DOI Listing

Incidence, prevalence, mortality, and causes of death in Waldenström macroglobulinemia: a nationwide, population-based cohort study.

BMC Cancer 2020 Jul 3;20(1):623. Epub 2020 Jul 3.

Division of Hematology-Oncology, Department of Internal Medicine, Kosin University College of Medicine, 262, Gamcheon-ro, Seo-gu, Busan, 49267, South Korea.

Background: The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, mortality, survival with competing risks, and causes of death of patients with WM.

Methods: We used a national population-based database, operated by the Health Insurance Review and Assessment Service of the Korean government. Read More

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http://dx.doi.org/10.1186/s12885-020-07120-9DOI Listing

Fine particulate matter constituents and cause-specific mortality in China: A nationwide modelling study.

Environ Int 2020 Jun 30;143:105927. Epub 2020 Jun 30.

Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou 511443, China; JNU-QUT Joint Laboratory for Air Quality Science and Management, Jinan University, Guangzhou 511443, China. Electronic address:

Background: Fine particulate matter (with aerodynamic diameter ≤2.5 µm, PM) causes huge disease burden worldwide. However, evidence is still inadequate and inconsistent on the relationships between PM constituents and mortality, especially in low resource settings. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105927DOI Listing

Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity.

Cancer Cell 2020 Jun 10. Epub 2020 Jun 10.

Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Telomerase is an attractive target for anti-tumor therapy as it is almost universally expressed in cancer cells. Here, we show that treatment with a telomere-targeting drug, 6-thio-2'-deoxyguanosine (6-thio-dG), leads to tumor regression through innate and adaptive immune-dependent responses in syngeneic and humanized mouse models of telomerase-expressing cancers. 6-thio-dG treatment causes telomere-associated DNA damages that are sensed by dendritic cells (DCs) and activates the host cytosolic DNA sensing STING/interferon I pathway, resulting in enhanced cross-priming capacity of DCs and tumor-specific CD8 T cell activation. Read More

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http://dx.doi.org/10.1016/j.ccell.2020.05.020DOI Listing

Exploring the Role of Phytochemicals as Potent Natural Photosensitizers in Photodynamic Therapy.

Anticancer Agents Med Chem 2020 Jul 3. Epub 2020 Jul 3.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein. South Africa.

Background: Cancer is still viewed as a deadly disease worldwide due to difficulties in diagnosis, painful treatment procedures, costly therapies, side effects and cancer relapse. Cancer treatments using conventional methods like chemotherapy and radiotherapy were not convincing due to its post-treatment toxicity in the host. In Photodynamic Therapy (PDT) three individual non-toxic components including a photosensitizer, light source and oxygen causes damage to the cells and tissues when they are combined. Read More

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http://dx.doi.org/10.2174/1871520620666200703192127DOI Listing

10H-3,6-Diazaphenothiazines triggered the mitochondrial-dependent and cell death receptor-dependent apoptosis pathways and further increased the chemosensitivity of MCF-7 breast cancer cells via inhibition of AKT1 pathways.

J Biochem Mol Toxicol 2020 Jul 3:e22544. Epub 2020 Jul 3.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Breast cancer is one of the leading causes of death in cancer categories, followed by lung, colorectal, and ovarian among the female gender across the world. 10H-3,6-diazaphenothiazine (PTZ) is a thiazine derivative compound that exhibits many pharmacological activities. Herein, we proceed to investigate the pharmacological activities of PTZ toward breast cancer MCF-7 cells as a representative in vitro breast cancer cell model. Read More

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http://dx.doi.org/10.1002/jbt.22544DOI Listing

An overview of three myeloproliferative neoplasms.

Nursing 2020 Jun 27. Epub 2020 Jun 27.

Jill Brennan-Cook is an assistant clinical professor of nursing at Duke University School of Nursing in Durham, N.C.

A group of rare hematologic cancers, myeloproliferative neoplasms (MPNs) evolve when bone marrow dysfunction causes overproduction of one or more blood cell types. This article explores the diagnosis, treatment, and nursing care of patients diagnosed with one of three classic MPNs: essential thrombocythemia, polycythemia vera, and primary myelofibrosis. Read More

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http://dx.doi.org/10.1097/01.NURSE.0000684184.44195.27DOI Listing

Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study.

Crit Care Med 2020 Jun 29. Epub 2020 Jun 29.

Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Objectives: To characterize the association between the use of physiologic assessment (central venous pressure, pulmonary artery occlusion pressure, stroke volume variation, pulse pressure variation, passive leg raise test, and critical care ultrasound) with fluid and vasopressor administration 24 hours after shock onset and with in-hospital mortality.

Design: Multicenter prospective cohort study between September 2017 and February 2018.

Settings: Thirty-four hospitals in the United States and Jordan. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004429DOI Listing

End-of-life care in schizophrenia: a systematic review.

Int Psychogeriatr 2020 Jun 19:1-19. Epub 2020 Jun 19.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Objective: Schizophrenia is a severe and persistent mental illness with profound effects on patients, families, and communities. It causes immense suffering on personal, emotional, and socioeconomic levels. Individuals with schizophrenia have poorer health outcomes and die 10-20 years younger than the general population. Read More

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http://dx.doi.org/10.1017/S1041610220000915DOI Listing

Diffuse Sarcoidosis Masquerading as Widespread Malignant Disease: A Rare Case Report and Literature Review.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620938942

James H. Quillen Veterans Affairs Medical Center, Mountain Home, TN, USA.

Sarcoidosis is a multisystem granulomatous disease commonly involving the lungs and mediastinal lymph nodes with the exact etiology being unclear. The simultaneous presence of malignant disease such as breast cancer and sarcoidosis has been reported. Sarcoidosis preceding a diagnosis of malignancy and that occurring years after treatment of malignant disease has been noted in the past. Read More

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http://dx.doi.org/10.1177/2324709620938942DOI Listing

Cinematic rendering enhancements to virtual bronchoscopy: assessment of emergent tracheal pathology.

Emerg Radiol 2020 Jul 2. Epub 2020 Jul 2.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.

Utilizing complex lighting models, cinematic rendering is a novel technique for demonstrating computed tomography data with exquisite 3D anatomic detail. The tracheal lumen, tracheal wall, and adjacent soft tissue structures are represented with photorealistic detail exceeding that of conventional volume rendering or virtual bronchoscopy techniques. We applied cinematic rendering to a spectrum of emergent tracheal pathologies: traumatic tracheal tears, tracheoesophageal fistulas, tracheal foreign bodies, tracheal stenosis (intrinsic and extrinsic causes), tracheal neoplasms, and tracheomalacia. Read More

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http://dx.doi.org/10.1007/s10140-020-01816-yDOI Listing

Female breast cancer mortality in relation to puberty on Staten Island, New York.

AIMS Public Health 2020 8;7(2):344-353. Epub 2020 Jun 8.

Center for Environmental Science, College of Staten Island, Staten Island, New York, USA.

Pursuant to a Congressional act in 2008, the Department of Health and Human Services established the Interagency Breast Cancer and Environmental Research Coordinating Committee to address the burden of breast cancer in the United States. Subsequently, the Committee recommended researchers study the timing of exposure to breast cancer risk factors. Given the high breast cancer mortality rate on Staten Island, this paper presents a case-control study investigating breast cancer risk associated with puberty while living on Staten Island. Read More

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http://dx.doi.org/10.3934/publichealth.2020029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327401PMC

Construction and Comprehensive Analysis of Dysregulated Long Noncoding RNA-Associated Competing Endogenous RNA Network in Moyamoya Disease.

Comput Math Methods Med 2020 13;2020:2018214. Epub 2020 Jun 13.

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.

Background: Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by chronic progressive stenosis or occlusion of the bilateral internal carotid artery (ICA), the anterior cerebral artery (ACA), and the middle cerebral artery (MCA). MMD is secondary to the formation of an abnormal vascular network at the base of the skull. However, the etiology and pathogenesis of MMD remain poorly understood. Read More

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http://dx.doi.org/10.1155/2020/2018214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306867PMC

Systems biology comprehensive analysis on breast cancer for identification of key gene modules and genes associated with TNM-based clinical stages.

Sci Rep 2020 Jul 2;10(1):10816. Epub 2020 Jul 2.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Breast cancer (BC), as one of the leading causes of death among women, comprises several subtypes with controversial and poor prognosis. Considering the TNM (tumor, lymph node, metastasis) based classification for staging of breast cancer, it is essential to diagnose the disease at early stages. The present study aims to take advantage of the systems biology approach on genome wide gene expression profiling datasets to identify the potential biomarkers involved at stage I, stage II, stage III, and stage IV as well as in the integrated group. Read More

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http://dx.doi.org/10.1038/s41598-020-67643-wDOI Listing

Gastrointestinal bleeding in patients with pancreatic cancer: Causes and haemostatic treatments.

United European Gastroenterol J 2020 Jul 2:2050640620939788. Epub 2020 Jul 2.

Department of Digestive Oncology, Beaujon Hospital, University of Paris, Clichy, France.

Background: Gastrointestinal bleeding is a rare but severe complication of pancreatic ductal adenocarcinoma.

Objective: The purpose of this study was to describe the causes and treatments of non-postoperative gastrointestinal bleeding in patients with pancreatic ductal adenocarcinoma, and explore the parameters associated with therapeutic effectiveness.

Methods: This was a single-centre observational retrospective study (2000-2017) with data collected from the prospectively coded diagnostic hospital's database system including patients with pancreatic ductal adenocarcinoma who had a gastrointestinal bleeding episode. Read More

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http://dx.doi.org/10.1177/2050640620939788DOI Listing

Polarization of M2 Macrophages by Interaction between Prostate Cancer Cells Treated with Trichomonas vaginalis and Adipocytes.

Korean J Parasitol 2020 Jun 26;58(3):217-227. Epub 2020 Jun 26.

Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul 04763, Korea.

Trichomonas vaginalis causes inflammation of the prostate and has been detected in tissues of prostate cancers (PCa), prostatitis and benign prostatic hyperplasia. Obesity is a risk factor for PCa and causes a chronic subclinical inflammation. This chronic inflammation further exacerbates adipose tissue inflammation as results of migration and activation of macrophages. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.3.217DOI Listing

Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology.

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):272-287. Epub 2020 Jun 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.272DOI Listing

Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival.

Mol Cell Endocrinol 2020 Jun 29:110932. Epub 2020 Jun 29.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK. Electronic address:

Pharmaceutical inhibitors of the endoplasmic reticulum (ER)-stress modulator PERK (eIF2AK3) have demonstrated anticancer activities in combination therapies, but their effectiveness as a single agent is limited, suggesting the existence of possible compensatory cellular responses. To explore the potential mechanisms involved, we performed time-course drug treatment experiments on the parental MCF-7 and drug resistant MCF-7Epi and MCF-7Tax breast cancer cells and identified GCN2 (eIF2AK4) as a molecule that can potentially cooperate with PERK to regulate FOXO3 via JNK and AKT to modulate drug response. Consistently, GCN2 knockdown severely impaired the clonal survival of parental and resistant MCF-7 cells and sensitised them to epirubicin and paclitaxel treatment. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110932DOI Listing

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Cell 2020 Jun 26. Epub 2020 Jun 26.

UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA; Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes & Metabolism, Harvard Medical School, Boston, MA, USA. Electronic address:

Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRα, Sca1, and CD81. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.021DOI Listing

Long noncoding RNA is highly expressed in colorectal cancer and predicts a poor prognosis.

Future Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. This study aimed to investigate the role of long noncoding RNA in CRC. The expression of in 103 cases of CRC tissues and four CRC cell lines was examined by quantitative real-time PCR. Read More

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http://dx.doi.org/10.2217/fon-2020-0393DOI Listing

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity.

Mol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Biosciences, Cancer Cluster Salzburg, Paris-Lodron University Salzburg, Salzburg, Austria.

Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug resistance poses major challenges to anti-HH treatments. In light of recent breakthroughs in cancer immunotherapy, we analyzed the possible immunosuppressive mechanisms in HH/GLI-induced BCC in detail. Read More

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http://dx.doi.org/10.1002/1878-0261.12758DOI Listing

Historical Perspectives on Ethical and Regulatory Aspects of Human Participants Research: Implications for Oncology Clinical Trials in Africa.

JCO Glob Oncol 2020 Jun;6:959-965

Synteract Limited, Cambridgeshire, United Kingdom.

Clinical trials research involving human participants has led to numerous medical advances. Historically, however, clinical trials research was the source of major concerns for the safety and welfare of the human participants taking part in these studies. The ethical principles of autonomy, beneficence, and justice came about in response to medical atrocities, and regulations were ultimately put in place to protect the rights and welfare of human participants and to maintain the public trust in the research enterprise. Read More

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http://dx.doi.org/10.1200/JGO.19.00196DOI Listing

Thermal Imaging - An Emerging Modality for Breast Cancer Detection: A Comprehensive Review.

J Med Syst 2020 Jul 1;44(8):136. Epub 2020 Jul 1.

Veermata Jijabai Technological Institute, Mumbai, India.

Breast cancer is not preventable. To reduce the death rate and improve the survival chances of breast cancer patients, early and accurate detection is the only panacea. Delay in diagnosis of this disease causes 60% of deaths. Read More

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http://dx.doi.org/10.1007/s10916-020-01581-yDOI Listing

Traditional Eastern European diet and mortality: prospective evidence from the HAPIEE study.

Eur J Nutr 2020 Jul 1. Epub 2020 Jul 1.

Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.

Purpose: Cardiovascular disease (CVD) and cancer mortality rates in Eastern Europe are among the highest in the world. Although diet is an important risk factor, traditional eating habits in this region have not yet been explored. This analysis assessed the relationship between traditional dietary pattern and mortality from all-causes, CVD and cancer in Eastern European cohorts. Read More

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http://dx.doi.org/10.1007/s00394-020-02319-9DOI Listing

Proteomic and Phosphoproteomic Maps of Lung Squamous Cell Carcinoma From Chinese Patients.

Front Oncol 2020 16;10:963. Epub 2020 Jun 16.

Chemical Proteomics Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Lung squamous cell carcinoma (LUSC) is one of the leading causes of tumor-driven deaths in the world. To date, studies on the tumor heterogeneity of LUSC at genomic level have only revealed limited therapeutic benefits. Therefore, system-wide research of LUSC at proteomic level may further improve precision medicine strategies on individual demands. Read More

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http://dx.doi.org/10.3389/fonc.2020.00963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308564PMC

Transcriptional Profiles of Skeletal Muscle Associated With Increasing Severity of White Striping in Commercial Broilers.

Front Physiol 2020 16;11:580. Epub 2020 Jun 16.

National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Pathum Thani, Thailand.

Development of the white striping (WS) abnormality adversely impacts overall quality of broiler breast meat. Its etiology remains unclear. This study aimed at exploring transcriptional profiles of broiler skeletal muscles exhibiting different WS severity to elucidate molecular mechanisms underlying the development and progression of WS. Read More

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http://dx.doi.org/10.3389/fphys.2020.00580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308426PMC

Nosocomial Infections in Gastrointestinal Cancer Patients: Bacterial Profile, Antibiotic Resistance Pattern, and Prognostic Factors.

Cancer Manag Res 2020 25;12:4969-4979. Epub 2020 Jun 25.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.

Background: Cancers of the gastrointestinal (GI) tract and its associated excretory glands are one of the most common causes of cancer-related death worldwide, and these patients are more likely to developing nosocomial infections due to immunodeficiency.

Objective: To explore the bacterial profile, antibiotic resistance pattern, and prognostic factors of nosocomial infections in hospitalized GI cancer patients.

Methods: All electronic medical records of nosocomial infection episodes in hospitalized GI cancer patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.2147/CMAR.S258774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323960PMC

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.

Nature 2020 Jul 1. Epub 2020 Jul 1.

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments and topologically associated domains (TADs) consisting of chromatin loops. TADs are formed by chromatin-loop extrusion, which depends on the loop-extrusion function of the ring-shaped cohesin complex. Conversely, the cohesin-release factor Wapl restricts loop extension. Read More

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http://dx.doi.org/10.1038/s41586-020-2454-yDOI Listing

Injury intensifies T cell mediated graft-versus-host disease in a humanized model of traumatic brain injury.

Sci Rep 2020 Jul 1;10(1):10729. Epub 2020 Jul 1.

Children's Regenerative Medicine Program, Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

The immune system plays critical roles in promoting tissue repair during recovery from neurotrauma but is also responsible for unchecked inflammation that causes neuronal cell death, systemic stress, and lethal immunodepression. Understanding the immune response to neurotrauma is an urgent priority, yet current models of traumatic brain injury (TBI) inadequately recapitulate the human immune response. Here, we report the first description of a humanized model of TBI and show that TBI places significant stress on the bone marrow. Read More

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http://dx.doi.org/10.1038/s41598-020-67723-xDOI Listing

Late mortality in survivors of childhood cancer in Hungary.

Sci Rep 2020 Jul 1;10(1):10761. Epub 2020 Jul 1.

2nd Department of Pediatrics, Semmelweis University, 7-9. Tűzoltó Str., 1094, Budapest, Hungary.

The Hungarian Pediatric Oncology Network provides centralized treatment and population-based registration for cases of childhood cancer since 1973. We collected and analized data on late mortality, secondary malignancies and cardiac diseases in survivors (> 5 years) of childhood cancer to evaluate long-term risks. We extracted all solid tumour cases (3,650 followed up for 5-39. Read More

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http://dx.doi.org/10.1038/s41598-020-67444-1DOI Listing

The SKI proto-oncogene restrains the resident CD103CD8 T cell response in viral clearance.

Cell Mol Immunol 2020 Jul 1. Epub 2020 Jul 1.

Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Acute viral infection causes illness and death. In addition, an infection often results in increased susceptibility to a secondary infection, but the mechanisms behind this susceptibility are poorly understood. Since its initial identification as a marker for resident memory CD8 T cells in barrier tissues, the function and regulation of CD103 integrin (encoded by ITGAE gene) have been extensively investigated. Read More

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http://dx.doi.org/10.1038/s41423-020-0495-7DOI Listing

Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions.

Sci Rep 2020 Jul 1;10(1):10741. Epub 2020 Jul 1.

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Indium compounds have been widely used in manufacturing displays of mobile phones, computers and televisions. However, inhalation exposure to indium compounds causes interstitial pneumonia in exposed workers and lung cancer in experimental animals. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed under inflammatory conditions and may participate in indium-induced carcinogenesis. Read More

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http://dx.doi.org/10.1038/s41598-020-67488-3DOI Listing

Germ cell depletion in recipient testis has adverse effects on spermatogenesis in orthotopically transplanted testis pieces via retinoic acid insufficiency.

Sci Rep 2020 Jul 1;10(1):10796. Epub 2020 Jul 1.

Department of Textile Science and Technology, Interdisciplinary Graduate School of Science and Technology, Shinshu University, Ueda, 386-8567, Japan.

Germ cell depletion in recipient testes is indispensable for successful transplantation of spermatogonial stem cells. However, we found that such treatment had an adverse effect on spermatogenesis of orthotopically transplanted donor testis tissues. In the donor tissue, the frequency of stimulated by retinoic acid (RA) 8 (STRA8) expression was reduced in germ cells, suggesting that RA signalling indispensable for spermatogenesis was attenuated in germ cell-depleted recipient testes. Read More

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http://dx.doi.org/10.1038/s41598-020-67595-1DOI Listing

Temporal trends in the healthy soldier effect in a cohort of Royal Norwegian Navy servicemen followed for 67 years.

Occup Environ Med 2020 Jul 1. Epub 2020 Jul 1.

Norwegian Armed Forces Joint Medical Services, Institute of Military Medicine and Epidemiology, Norwegian Armed Forces, Ullensaker, Norway.

Objectives: To investigate temporal trends in the 'healthy soldier effect' (HSE) among 28 300 Royal Norwegian Navy servicemen who served during 1950-2004.

Methods: Standardised mortality ratios (SMRs) for all causes, diseases and external causes were calculated from national rates for the entire study period (1951-2017), and for seven successive follow-up periods after the first recorded day of Naval service, for the overall cohort and for two subgroups: land-based personnel and vessel crews. Poisson regression, expressed as rate ratios, was used to compare all-cause mortality between the subgroups. Read More

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http://dx.doi.org/10.1136/oemed-2020-106475DOI Listing

The Gut Microbiota Impacts Cancer Etiology through "Phase IV Metabolism" of Drugs and Endobiotics.

Cancer Prev Res (Phila) 2020 Jul 1. Epub 2020 Jul 1.

Chemistry, UNIVERSITY OF NORTH CAROLINA AT CHAPEL H

The human gut microbiome intimately complements the human genome and gut microbial factors directly influence health and disease. Here we outline how the gut microbiota uniquely contributes to cancer etiology by processing products of human drug and endobiotic metabolism. We formally propose that the reactions performed by the gut microbiota should be classified as "Phase IV xenobiotic and endobiotic metabolism". Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-20-0155DOI Listing

Recommended physical activity and all cause and cause specific mortality in US adults: prospective cohort study.

BMJ 2020 Jul 1;370:m2031. Epub 2020 Jul 1.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan250012, China

Objective: To determine the association between recommended physical activity according to the 2018 physical activity guidelines for Americans and all cause and cause specific mortality using a nationally representative sample of US adults.

Design: Population based cohort study.

Setting: National Health Interview Survey (1997-2014) with linkage to the National Death Index records to 31 December 2015. Read More

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http://dx.doi.org/10.1136/bmj.m2031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328465PMC

A Prospective Analysis of Intake of Red and Processed Meat in Relation to Pancreatic Cancer among African American Women.

Cancer Epidemiol Biomarkers Prev 2020 Jul 1. Epub 2020 Jul 1.

Slone Epidemiology Center, Boston University.

Background: African Americans have the highest incidence of pancreatic cancer of any racial/ethnic group in the US. There is evidence that consumption of red or processed meat and foods containing saturated fats may increase the risk of pancreatic cancer, but there is limited evidence in African Americans.

Methods: Utilizing the Black Women's Health Study (1995-2018), we prospectively investigated the associations of red and processed meat and saturated fats with incidence of pancreatic adenocarcinoma (n=168). Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-20-0048DOI Listing

Effect of socioeconomic deprivation on outcomes of diabetes complications in patients with type 2 diabetes mellitus: a nationwide population-based cohort study of South Korea.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Department Preventive Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)

Introduction: This study aimed to examine the effect of socioeconomic deprivation on the outcomes of diabetes complications in patients with type 2 diabetes mellitus (T2DM).

Research Design And Methods: We conducted a cohort study using claims data and 2005 national census data. We included of 7510 patients newly diagnosed with T2DM from 2004 to 2012 and aged 40 years or above. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000729DOI Listing
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