5,621 results match your criteria Cancer biotherapy & radiopharmaceuticals[Journal]


Resurrecting a p53 peptide activator - An enabling nanoengineering strategy for peptide therapeutics.

J Control Release 2020 Jul 9. Epub 2020 Jul 9.

Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

Many high-affinity peptide antagonists of MDM2 and MDMX have been reported as activators of the tumor suppressor protein p53 with therapeutic potential. Unfortunately, peptide activators of p53 generally suffer poor proteolytic stability and low membrane permeability, posing a major pharmacological challenge to anticancer peptide drug development. We previously obtained several potent dodecameric peptide antagonists of MDM2 and MDMX termed PMIs, one of which, TSFAEYWALLSP, bound to MDM2 and MDMX at respective affinities of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2020.06.041DOI Listing

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.

Signal Transduct Target Ther 2019 Jul 12;4(1):25. Epub 2019 Jul 12.

Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China.

Tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR TKIs) greatly improved clinical outcomes of patients with non-small cell lung cancer (NSCLC). Unfortunately, primary and acquired resistance limits their clinical benefits. To overcome such resistance, new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-019-0059-4DOI Listing

Accuracy of real-time respiratory motion tracking and time delay of gating radiotherapy based on optical surface imaging technique.

Radiat Oncol 2020 Jul 10;15(1):170. Epub 2020 Jul 10.

Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Background: Surface-guided radiation therapy (SGRT) employs a non-invasive real-time optical surface imaging (OSI) technique for patient surface motion monitoring during radiotherapy. The main purpose of this study is to verify the real-time tracking accuracy of SGRT for respiratory motion and provide a fitting method to detect the time delay of gating.

Methods: A respiratory motion phantom was utilized to simulate respiratory motion using 17 cosine breathing pattern curves with various periods and amplitudes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-020-01611-6DOI Listing

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.

Eur J Med Chem 2020 Jun 27;202:112519. Epub 2020 Jun 27.

School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China. Electronic address:

A series of Pyrazolo[1,5-a]Pyrimidine analogs were designed and synthesized as novel tubulin inhibitors. Among them, compounds 1a and 1b showed the highest antiproliferative activity against a panel of cancer cell lines with average IC values of 24.8 nM and 28 nM, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2020.112519DOI Listing
June 2020
3.447 Impact Factor

Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study.

Toxicol Lett 2020 Jul 7;332:65-73. Epub 2020 Jul 7.

Key Laboratory of Environment-Friendly Chemistry and Application of Ministry of Education, Lab of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan 411105, PR China. Electronic address:

Exposure to multi-walled carbon nanotubes (MWCNTs) might induce lipid droplet (LD) biogenesis, but the roles of physicochemical properties of MWCNTs, as well as the mechanisms, remain poorly understood. In this study, we investigated lipid laden foam formation in THP-1 macrophages exposed to MWCNTs of different diameters, and attempted transcriptomic analysis to study the possible mechanisms. We observed diameter-dependent cytotoxicity, lipid accumulation and intracellular reactive oxygen species production that were more pronounced for MWCNTs with smaller diameters compared with those with larger diameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2020.07.007DOI Listing

Kang-ai Injection () Inhibits Gastric Cancer Cells Proliferation through IL-6/STAT3 Pathway.

Chin J Integr Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, 110001, China.

Objective: To explore the mechanisms underlying the proliferative inhibition of Chinese herbal medicine Kang-ai injection (KAI, ) in gastric cancer cells.

Methods: Gastric cancer cell lines MGC803 and BGC823 were treated by 0, 0.3%, 1%, 3% and 10% KAI for 24, 48 and 72 h, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11655-020-3265-6DOI Listing

Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation.

Signal Transduct Target Ther 2020 Jul 10;5(1):117. Epub 2020 Jul 10.

Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai, China.

Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition, which is characterized by vasculogenic mimicry (VM). VM not only accelerates tumor progression but also increases drug-induced resistance. However, very little is currently known about the molecular determinants that enable VM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-020-0167-1DOI Listing

Enhancement of the antitumor effect of HER2-directed CAR-T cells through blocking epithelial-mesenchymal transition in tumor cells.

FASEB J 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

The efficacy of chimeric antigen receptor T (CAR-T) cell therapy in solid tumors is far from satisfactory. In this study, we investigated the influence of epithelial-mesenchymal transition (EMT) on the antitumor effect of CAR-T cells and explored the potential efficacy of combining CAR-T cells with inhibitors targeting EMT. We successfully induced EMT in tumor cells with TGF-β1, and the antitumor effect of HER2-directed CAR-T cells was significantly suppressed by EMT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.202000080RRDOI Listing
July 2020
5.043 Impact Factor

The relationship between gut microbiota and short chain fatty acids in the renal calcium oxalate stones disease.

FASEB J 2020 Jul 9. Epub 2020 Jul 9.

Department of Urology, Laboratory of Reconstructive Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

The relationship of gut microbiota and calcium oxalate stone has been limited investigated, especially with no study of gut microbiota and short chain fatty acids (SCFAs) in nephrolithiasis. We provided Sprague Dawley rats of renal calcium oxalate stones with antibiotics and examined the renal crystals deposition. We also performed a case-control study by analyzing 16S rRNA microbial profiling, shotgun metagenomics and SCFAs in 153 fecal samples from non-kidney stone (NS) controls, patients with occasional renal calcium oxalate stones (OS) and patients with recurrent stones (RS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.202000786RDOI Listing

Nuclear delivery of dual anticancer drug-based nanomedicine constructed by cisplatinum-induced peptide self-assembly.

Nanoscale 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, P. R. China. and College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China. and Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China.

Nuclear delivery of anticancer drugs, particularly dual complementary anticancer drugs, can significantly improve chemotherapy efficacy. However, successful examples are rare. We reported a novel dual anticancer drug-based nanomedicine with nuclear accumulation properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0nr00143kDOI Listing

Delivery strategies for macromolecular drugs in cancer therapy.

Authors:
Qin Guo Chen Jiang

Acta Pharm Sin B 2020 Jun 26;10(6):979-986. Epub 2020 Jan 26.

Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

With the development of biotherapy, biomacromolecular drugs have gained tremendous attention recently, especially in drug development field due to the sophisticated functions . Over the past few years, a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability, ., the instability and easily restricted by physiologic barriers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.apsb.2020.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332661PMC

Chromosome Abnormalities: New Insights into Their Clinical Significance in Cancer.

Mol Ther Oncolytics 2020 Jun 26;17:562-570. Epub 2020 May 26.

Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Chromosomal abnormalities, consisting of numerical and structural chromosome abnormalities, are a common characteristic of cancer. Numerical chromosome abnormalities, mainly including aneuploidy and chromosome instability, are caused by chromosome segregation errors in mitosis, whereas structural chromosome abnormalities are a consequence of DNA damage and comprise focal/arm-level chromosome gain or loss. Recent advances have started to unveil the mechanisms by which chromosomal abnormalities can facilitate tumorigenesis and change the cellular fitness and the expression or function of RNAs and proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omto.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321812PMC

Durable Response and Good Tolerance to the Triple Combination of Toripalimab, Gemcitabine, and Nab-Paclitaxel in a Patient With Metastatic Pancreatic Ductal Adenocarcinoma.

Front Immunol 2020 19;11:1127. Epub 2020 Jun 19.

Department of Abdominal Oncology, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

The performance of immune checkpoint inhibitor (ICI) monotherapy was proved to be disappointing in pancreatic ductal adenocarcinoma (PDAC). Increasing evidence has shown the promising efficacy of ICIs combined with systemic therapy in the first-line treatment in solid tumors. We reported a case of a metastatic PDAC patient who had a long-term partial response and good tolerance to the combined approach of toripalimab (a novel PD-1 inhibitor) and gemcitabine plus nab-paclitaxel (GA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.01127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318868PMC

Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.

Cancer Immunol Immunother 2020 Jul 6. Epub 2020 Jul 6.

Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, People's Republic of China.

Romidepsin (FK228), a histone deacetylase inhibitor (HDACi), has anti-tumor effects against several types of solid tumors. Studies have suggested that HDACi could upregulate PD-L1 expression in tumor cells and change the state of anti-tumor immune responses in vivo. However, the influence of enhanced PD-L1 expression in tumor cells induced by romidepsin on anti-tumor immune responses is still under debate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00262-020-02653-1DOI Listing

An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway.

Cancer Gene Ther 2020 Jul 7. Epub 2020 Jul 7.

Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Tumor organoids recapitulate pathological properties and would serve as an excellent ex vivo model for drug discovery. Here, we performed an unbiased drug screening on drivers-defined tumor organoids from mouse endometrial cancer, the most prevalent gynecological malignancy in human, with a small molecule library targeting epigenetic factors. Among them, menin-MLL inhibitors MI-136 and MI-463 scored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41417-020-0190-yDOI Listing

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.

Oncogenesis 2020 Jul 6;9(7):65. Epub 2020 Jul 6.

Department of Biotherapy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, and School of Life Sciences, Sun Yat-sen University, 510060, Guangzhou, P. R. China.

Galectin-9 (Gal-9) is known to enhance the expansion of myeloid-derived suppressor cells (MDSCs) in murine models. Its contribution to the expansion of MDSCs in human malignancies remain to be investigated. We here report that Gal-9 expression in nasopharyngeal carcinoma (NPC) cells enhances the generation of MDSCs (CD33CD11bHLA-DR) from CD33 bystander cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41389-020-00248-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338349PMC

Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.

Bioorg Med Chem Lett 2020 Aug 25;30(16):127215. Epub 2020 Apr 25.

Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address:

SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new SIRT6 inhibitors containing the skeleton 1-phenylpiperazine. Among them, compound 5-(4-methylpiperazin-1-yl)-2-nitroaniline (6d) is the most potent one, which showed an IC value of 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2020.127215DOI Listing

Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code.

Antioxid Redox Signal 2020 Jul 6. Epub 2020 Jul 6.

Sichuan University, 12530, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China;

Significance: Metabolic reprogramming is considered to be a critical adaptive biological event that fulfills the energy and biomass demands for cancer cells. One hallmark of metabolic reprogramming is reduced oxidative phosphorylation and enhanced aerobic glycolysis. Such metabolic abnormalities contribute to the accumulation of reactive oxygen species (ROS), the byproducts of metabolic pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2020.8123DOI Listing

Prevalence of food allergen and aeroallergen sensitization among children in Sichuan province.

Medicine (Baltimore) 2020 Jul;99(27):e21055

Department of Laboratory Medicine, West China Second University Hospital, and Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education.

Food allergen and aeroallergen sensitization are common allergic diseases worldwide, with widely varying estimates of prevalence in children. Our study investigated the characteristics of ingestion and inhalation allergy among children from Sichuan province in Southwest China, so as to get public awareness of these disorders.A total of 1722 children between 0 and 14 years' old were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000021055DOI Listing

Advances in the occurrence and biotherapy of osteoporosis.

Biochem Soc Trans 2020 Jul 6. Epub 2020 Jul 6.

Jiangxi University of Science and Technology, Ganzhou 341000, China.

Osteoporosis (OP) is a bone metabolic disease, is characterized by degeneration of bone structure and decreased bone mass. It happens in more than 1/3 women and 1/5 men of over than 50 years old, which affects the health and lives of people. The main mechanism of OP is mainly that the dynamic balance between the bone formation and resorption is broken, so that bone resorption is more than bone formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20200005DOI Listing

Nomogram based on pre-treatment inflammatory biomarkers predicting survival in patients with head and neck soft tissue sarcoma.

Cancer Biomark 2020 Jul 3. Epub 2020 Jul 3.

Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, Sichuan, China.

Background: Systemic inflammatory biomarkers reflect level of inflammatory response, which have been suggested as prognostic factors in cancer patients.

Objective: To estimate the prognostic value of inflammatory biomarkers in 149 patients with head and neck soft tissue sarcoma (HNSTS).

Methods: Pre-treatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), neutrophil-platelet score (NPS) and Aarhus Composite Biomarker Score (ACBS) were analyzed for association with overall survival (OS) and progression-free survival (PFS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/CBM-201739DOI Listing

Ga-PSMA PET/MRI for the diagnosis of primary and biochemically recurrent prostate cancer: A meta-analysis.

Eur J Radiol 2020 Jun 20;130:109131. Epub 2020 Jun 20.

Department of Nuclear Medicine, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan, China. Electronic address:

Purpose: Our meta-analysis aimed to evaluate the diagnostic performance of Ga-labelled prostate-specific membrane antigen ligand positron emission tomography/magnetic resonance imaging (Ga-PSMA PET/MRI) in patients with primary and biochemically recurrent prostate cancer (PCa).

Methods: We searched for relevant articles in PubMed, EMBASE, the Cochrane Library and Web of Science until September 12, 2019. Studies regarding the diagnostic performance ofGa-PSMA PET/MRI in detecting primary PCa and biochemical recurrence (BCR) after definitive treatment were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejrad.2020.109131DOI Listing

Developing novel computational prediction models for assessing chemical-induced neurotoxicity using naïve Bayes classifier technique.

Food Chem Toxicol 2020 Jul 1;143:111513. Epub 2020 Jul 1.

College of Life Science, Northwest Normal University, Lanzhou, Gansu, 730070, PR China.

Development of reliable and efficient alternative in vivo methods for evaluation of the chemicals with potential neurotoxicity is an urgent need in the early stages of drug design. In this investigation, the computational prediction models for drug-induced neurotoxicity were developed by using the classical naïve Bayes classifier. Eight molecular properties closely relevant to neurotoxicity were selected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2020.111513DOI Listing

A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.

Org Biomol Chem 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Installation of a nitrogen at the C6 position of artemisinin facilitates the addition of a functional unit on the cyclohexane moiety (C-ring). In this study, conjugation of an amphiphilic chain, composed of sequentially connected hydrophilic oligoethylene glycol, hydrophobic alkyl chain, urea, and 4,4'-disubstituted biphenyl linker, imparted self-assembling properties. The fully synthetic mid-molecular weight 6-aza-artemisinin 6 bearing the amphiphilic moiety formed aggregates (approx. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0ob00919aDOI Listing

Systematic profiling of alternative splicing in -negative gastric cancer and their clinical significance.

Cancer Cell Int 2020 30;20:279. Epub 2020 Jun 30.

Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001 Liaoning China.

Background: Alternative splicing (AS) may cause structural and functional variations in the protein to promote the proliferation of tumor cells. However, there is no comprehensive analysis of the clinical significance of AS in -negative gastric cancer (HP GC).

Methods: The clinical, gene expression profile data and AS events of 138 HP GC patients were obtained from the database named the cancer genome atlas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-020-01368-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325377PMC

Anticancer Effects of ACT001 via NF-κB Suppression in Murine Triple-Negative Breast Cancer Cell Line 4T1.

Cancer Manag Res 2020 26;12:5131-5139. Epub 2020 Jun 26.

Lung Cancer Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.

Purpose: ACT001 is a novel sesquiterpene lactone derivative with anticancer effects, including the reversal of tamoxifen resistance in estrogen receptor-positive breast cancer cells. However, few studies have investigated the anticancer effects of ACT001 in triple-negative breast cancer (TNBC), a highly aggressive cancer with a poor prognosis. This study aimed to investigate the effects of ACT001 on TNBC and the potential mechanism underlying these effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S244748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326172PMC

Overcoming cancer therapeutic bottleneck by drug repurposing.

Signal Transduct Target Ther 2020 Jul 2;5(1):113. Epub 2020 Jul 2.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041, Chengdu, China.

Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing, the development of old drugs for new therapeutic purposes. This strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease, facilitating rapid clinical translation. With an increased understanding of the hallmarks of cancer and the development of various data-driven approaches, drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-020-00213-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331117PMC

The SKI proto-oncogene restrains the resident CD103CD8 T cell response in viral clearance.

Cell Mol Immunol 2020 Jul 1. Epub 2020 Jul 1.

Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Acute viral infection causes illness and death. In addition, an infection often results in increased susceptibility to a secondary infection, but the mechanisms behind this susceptibility are poorly understood. Since its initial identification as a marker for resident memory CD8 T cells in barrier tissues, the function and regulation of CD103 integrin (encoded by ITGAE gene) have been extensively investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41423-020-0495-7DOI Listing

A novel fluorescent probe with dual-sites for simultaneously monitoring metabolisms of cysteine in living cells and zebrafishes.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 15;241:118602. Epub 2020 Jun 15.

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.

Understanding cellular metabolism holds immense potential for developing new drugs that regulate metabolic pathways. Two gas signal molecules, SO and HS, are the main metabolites from cysteine (Cys) via oxidation and desulfurization pathways, respectively. However, a few fluorescent probes for real-time monitor of the metabolic pathways of cysteine have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118602DOI Listing

Turning Cold into Hot: Firing up the Tumor Microenvironment.

Trends Cancer 2020 Jul 21;6(7):605-618. Epub 2020 Mar 21.

Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 100005 Beijing, China. Electronic address:

Cancers develop within complex tissue environments consisting of diverse innate and adaptive immune cells, along with stromal cells, vascular networks, and many other cellular and noncellular components. The high heterogeneity within the tumor microenvironment (TME) remains a key obstacle in understanding and treating cancer. Understanding the dynamic functional interplay within this intricate ecosystem will provide important insights into the design of effective combinatorial strategies against cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trecan.2020.02.022DOI Listing

Risk and impact of invasive fungal infections in patients with multiple myeloma.

Ann Hematol 2020 Aug 1;99(8):1813-1822. Epub 2020 Jul 1.

Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201 Shipai Road, Sec. 2, Taipei, 11217, Taiwan.

Infection is associated with great morbidity and mortality in patients with multiple myeloma (MM), but evidence for invasive fungal infections (IFIs) is lacking. We aimed to investigate risk factors for IFI in MM patients and to determine its impact on patients' survival. We retrospectively analyzed MM patients at Taipei Veterans General Hospital in Taiwan between January 2002 and October 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-020-04125-zDOI Listing
August 2020
2.634 Impact Factor

Comprehensive Analysis of PD-1 Gene Expression, Immune Characteristics and Prognostic Significance in 1396 Glioma Patients.

Cancer Manag Res 2020 10;12:4399-4410. Epub 2020 Jun 10.

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People's Republic of China.

Background: Programmed cell death protein-1 (PD-1) blockade therapy is one of the most remarkable immunotherapy strategies in many solid tumors, excluding glioma. The PD-1 expression, immune characteristics, and prognosis relevance in glioma remain poorly understood.

Patients And Methods: RNA sequencing (RNA-seq) and mRNA microarray data were obtained for 325 and 301 glioma patients, respectively, from the Chinese Glioma Genome Atlas (CGGA) database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S238174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294103PMC

PD-L1 exosomes from bone marrow-derived cells of tumor-bearing mice inhibit antitumor immunity.

Cell Mol Immunol 2020 Jun 30. Epub 2020 Jun 30.

Department of Infectious Disease, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, 310052, Hangzhou, China.

Tumors escape immune attack by upregulating the surface expression of PD-L1, which interacts with PD-1 on T cells to activate immune inhibitory signaling. Anti-PD-1 treatments can effectively block this inhibitory signaling and activate antitumor immune responses. However, anti-PD-1 treatment also has a tumor suppressive effect in patients whose tumor cells do not express PD-L1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41423-020-0487-7DOI Listing

Recent Patents on the Development of c-Met Kinase Inhibitors.

Recent Pat Anticancer Drug Discov 2020 Jun 29. Epub 2020 Jun 29.

School of Pharmacy, Yantai University, 30 Qingquan Road, Yantai, 264005, Shandong. China.

Background: Receptor Tyrosine Kinases (RTKs) play critical roles in a variety of cellular processes including growth, differentiation and angiogenesis, and in the development and progression of many types of cancer. Mesenchymal- Epithelial Transition Factor (c-Met) kinase is one type of RTK, and becoming an attractive target for anti-tumor drug designing. c-Met inhibitors have a broad prospect in the tumor prevention, chemotherapy, biotherapy, especially in the tumor resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574892815666200630102344DOI Listing

Gene Therapy (Part I).

Curr Gene Ther 2020 ;20(1)

Department of Pharmacy, Cancer Center and National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu, Sichuan 610041, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/156652322001200604150311DOI Listing
January 2020

Regio- and Enantioselective Palladium-Catalyzed Asymmetric Allylation of -Fluorenyl Trifluoromethyl Imine.

Org Lett 2020 Jun 30. Epub 2020 Jun 30.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P.R. China.

A palladium-catalyzed asymmetric allylation of -fluorenyl trifluoromethyl imine with allylic acetates is disclosed. This method provides scalable and efficient access to polysubstituted chiral α-trifluoromethyl amines bearing two adjacent stereocenters and one allyl group in high yields with excellent regio-, diastereo-, and enantioselectivity. Importantly, this method also provides a powerful strategy for the synthesis of both regioisomeric products and the regioselectivity is controlled by the chiral catalysts and optically active substrates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.0c01836DOI Listing

Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets.

Front Neurosci 2020 11;14:479. Epub 2020 Jun 11.

Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, China.

Objective: Prior studies have shown that there is an inverse association between birth weight and stroke in adulthood; however, whether such association is causal remains yet known and those studies cannot distinguish between the direct fetal effect and the indirect maternal effect. The aim of the study is to untangle such relationship using novel statistical genetic approaches.

Methods: We first utilized linkage disequilibrium score regression (LDSC) and Genetic analysis incorporating Pleiotropy and Annotation (GPA) to estimate the overall genetic correlation between birth weight and stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2020.00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301963PMC

Gata2 -77 enhancer regulates adult hematopoietic stem cell survival.

Leukemia 2020 Jun 27. Epub 2020 Jun 27.

McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-020-0942-6DOI Listing

The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation.

Hormones (Athens) 2020 Jun 26. Epub 2020 Jun 26.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China.

Background: The progression of endometrial cancer (EC) is closely related to estrogen levels. UDP-glucuronosyltransferases (UGTs) are an essential class of phase II metabolizing enzymes that play a pivotal role in detoxifying steroid hormone.

Purpose: In this study, we aimed to uncover the role of UGTs in estrogen metabolism and the pathogenesis of EC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42000-020-00213-xDOI Listing
June 2020
1.237 Impact Factor

GLI1 expression in pancreatic ductal adenocarcinoma correlates the clinical significance and prognosis: A meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20950

Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy.

Background: Glioma-associated oncogene homolog 1(GLI1) expression correlates with the clinical significance and prognosis of several cancers. However, the evaluation of the role GLI1 expression plays in pancreatic ductal adenocarcinoma (PDAC) clinicopathological features and outcomes still lacks.

Objective: The present study systemic reviewed the association of GLI1 expression and clinical significance as well as patients survival in PDAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329021PMC

Clinical efficacy of adjuvant chemotherapy in the treatment of pT4 stage II colorectal cancer with defective mismatch repair status: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20693

Department of Gastrointestinal Surgery, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.

Background: The aim of this systematic review and meta-analysis is to assess the efficacy of adjuvant chemotherapy in patients with stage IIB/C CRC and defective mismatch repair (dMMr) status, and to evaluate what is the determinant risk factor for adjuvant chemotherapy in those patients.

Method: A systematic search of PubMed, EMBASE, Web of science, Cochrane Library databases will be performed. All RCTs published in electronic databases from inception to March 19, 2020, with language restricted in English will be included in this review study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328979PMC

6H2L, a novel synthetic derivative of bifendate, induces apoptosis in hepatoma cells via mitochondrial and MAPK pathway.

Eur J Pharmacol 2020 Jun 23:173299. Epub 2020 Jun 23.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, People's Republic of China. Electronic address:

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Our previous study indicated that 6H2L, a novel synthetic bifendate derivative, shows multidrug resistance reversal activity, while its antitumor effect has not been revealed. Here, the potent antitumor effects of 6H2L on hepatoma cells both in vitro and in vivo were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2020.173299DOI Listing

CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.

Cancer Biol Med 2020 May;17(2):357-370

Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

The E3 ligase, CRL4, plays diverse roles in different cellular processes, such as DNA damage, transcriptional regulation, cell cycle progression, and cell apoptosis. Our previous study showed that CUL4A and CUL4B had a strong association with tobacco smoking risk in lung squamous cell carcinoma (SCC) and small cell lung carcinoma (SCLC). This study aimed to define the potential mechanism underlying the roles of CUL4A and CUL4B in the development of SCC and SCLC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309472PMC

A machine learning-based prognostic predictor for stage III colon cancer.

Sci Rep 2020 Jun 25;10(1):10333. Epub 2020 Jun 25.

Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu, China.

Limited biomarkers have been identified as prognostic predictors for stage III colon cancer. To combat this shortfall, we developed a computer-aided approach which combing convolutional neural network with machine classifier to predict the prognosis of stage III colon cancer from routinely haematoxylin and eosin (H&E) stained tissue slides. We trained the model by using 101 cancers from West China Hospital (WCH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67178-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316723PMC

TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition.

Cell Death Dis 2020 Jun 25;11(6):482. Epub 2020 Jun 25.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, 610041, Chengdu, Sichuan, P.R. China.

Transcription factors are known to mediate the conversion of somatic cells to induced pluripotent stem cells (iPSCs). Transcription factor TFAP2C plays important roles in the regulation of embryonic development and carcinogenesis; however, the roles of Tfap2c in regulating somatic cell reprogramming are not well understood. Here we demonstrate Tfap2c is induced during the generation of iPSCs from mouse fibroblasts and acts as a facilitator for iPSCs formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-020-2684-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316975PMC

Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity.

Steroids 2020 Jun 22:108677. Epub 2020 Jun 22.

Department of Pediatric Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Chengdu 610041, China. Electronic address:

Bisphenol A (BPA) [2,2-bis(4-hydroxyphenyl) propane] has attracted increasing attention over the past few decades as an endocrine-disrupting chemicals that causes low testosterone levels. Linoleic acid (LA) is an essential fatty acid and GPR120 agonist. Herein, we are the first to report that LA induces the expression of GPR120 in mouse Leydig cells to directly promote testosterone production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.steroids.2020.108677DOI Listing

ROS-Activatable siRNA-Engineered Polyplex for NIR-Triggered Synergistic Cancer Treatment.

ACS Appl Mater Interfaces 2020 Jul 9. Epub 2020 Jul 9.

School of Life Science; Advanced Research Institute of Multidisciplinary Science; Institute of Engineering Medicine; Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, P. R. China.

Small interfering RNA (siRNA) shows excellent pharmaceutical prospects in treating diverse life-threatening diseases. Photodynamic therapy (PDT) is a clinically employed noninvasive treatment method that can trigger selective damage toward targeted tissue and cells. However, insufficient delivery of siRNA and photosensitizer to cancer cells remarkably hindered the application of siRNA and PDT in the treatment of cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c06614DOI Listing

A 17q24.3 duplication identified in a large Chinese family with brachydactyly-anonychia.

Mol Genet Genomic Med 2020 Jun 25:e1392. Epub 2020 Jun 25.

Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Background: Brachydactyly (BD) is a rare autosomal dominant inherited disease characterized by shortness of the fingers and/or toes, which has been classified into the subtypes A-E. However, the exact cause and mechanism of BD remain to be illuminated. Here, we aim to reveal the clinical and genetic characteristics of a subtype of BD, brachydactyly-anonychia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.1392DOI Listing

Relationship between periodontal disease and lung cancer: A systematic review and meta-analysis.

J Periodontal Res 2020 Jun 25. Epub 2020 Jun 25.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Periodontal disease (PD), as a chronic bacterial infection, might cause cardiovascular and some other systemic diseases, with recent studies reporting that it exhibits some connection with lung cancer. While studies have shown that poor oral health might increase the risk of lung cancer, the veracity of these reports is questionable. Therefore, this meta-analysis was undertaken to investigate the association between PD and the risk of lung cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jre.12772DOI Listing

Assessment of Nine Driver Gene Mutations in Surgically Resected Samples from Patients with Non-Small-Cell Lung Cancer.

Cancer Manag Res 2020 28;12:4029-4038. Epub 2020 May 28.

Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Background: The mutational profile of oncogenic driver genes play an important role in non-small-cell lung cancer (NSCLC). The need of a testing panel capable of comprehensively determining patient genotypes in limited amounts of material has increased since the recent association of nine core oncogenic driver genes as tumor predictive biomarkers.

Methods: Surgically resected samples from 214 NSCLC patients (168 patients with adenocarcinomas and 46 with squamous cell cancers) were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S250822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269179PMC