10 results match your criteria Cancer and clinical oncology[Journal]

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Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model.

Cancer Clin Oncol 2017 May 11;6(1):12-24. Epub 2016 Nov 11.

Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

The ability of stress to induce immune suppression is widely recognized, but the mechanisms underlying the effects of stress on the adaptive immune system during tumor progression are not completely understood. To study the effect of stress on the immune system , we used a preclinical immunocompetent mouse model bearing 4T1 mammary adenocarcinoma cells. Mice were randomized into 4 groups, including social isolation (SI), acute restraint stress (aRRS), chronic restraint stress (cRRS), or no stress (NS). Read More

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http://dx.doi.org/10.5539/cco.v6n1p12DOI Listing
May 2017
79 Reads

Weight Management to Reduce Prostate Cancer Risk: A Survey of Men's Needs and Interests.

Cancer Clin Oncol 2016 May;5(1):43-52

Department of Dietetics & Nutrition, School of Health Professions, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mailstop 4013, Kansas City, Kansas 66160, USA ; Department of Urology Surgery, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 3016, Kansas City, Kansas 66160, USA.

Obese men have a higher rate of prostate cancer-related death than non-obese men, and obesity increases the risk of prostate cancer progression and biochemical recurrence. The purpose of this study was to assess needs and interests of men for a technology-driven weight loss intervention to reduce prostate cancer risk. We distributed a survey collecting demographic characteristics, health history, exercise and eating habits (and perception of those habits), current and prior attempts of health behavior change, and technology use. Read More

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http://dx.doi.org/10.5539/cco.v5n1p43DOI Listing
May 2016
15 Reads

Methylation Markers for Early Detection and Differentiation of Follicular Thyroid Cancer Subtypes.

Cancer Clin Oncol 2015 Nov 15;4(2):1-12. Epub 2015 Jun 15.

Department of Otolaryngology/Head and Neck Research, Henry Ford Hospital, Detroit, Michigan 48202, USA.

Thyroid cancer has the fastest rising incidence rates and is the fifth most common cancer in women. There are four main types of which the papillary and follicular types together account for >90%, followed by medullary cancers (3%-5%) and anaplastic carcinomas (<3%). For individuals who present with early stage disease of papillary and follicular cancers, there are no accurate markers to predict whether they will develop metastatic or recurrent disease. Read More

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http://dx.doi.org/10.5539/cco.v4n2p1DOI Listing
November 2015
40 Reads

Colorectal Cancer Survival Disparities among Puerto Rican Hispanics: A Comparison to Racial/Ethnic Groups in the United States.

Cancer Clin Oncol 2016 24;5(2):29-37. Epub 2016 Aug 24.

University of Puerto Rico Comprehensive Cancer Center, San Juan, PR.

Purpose: Ethnic/racial disparities in colorectal cancer (CRC) survival have been well documented. However, there is limited information regarding CRC survival among Hispanic subgroups. This study reports the 5-year relative survival of Puerto Rican Hispanic (PRH) CRC patients and the relative risk of death compared to other racial/ethnic groups in the US. Read More

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http://dx.doi.org/10.5539/cco.v5n2p29DOI Listing
August 2016
3 Reads

The Insulin-like Growth Factor Axis, Adipokines, Physical Activity, and Obesity in Relation to Breast Cancer Incidence and Recurrence.

Cancer Clin Oncol 2015;4(2):24-31

Institute of Public and Preventive Health, and Department of Family Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.

Background: Obesity, a risk factor for the development of postmenopausal breast cancer and certain other cancer types, has also been associated with poorer response to cancer therapy and cancer recurrence. The insulin-like growth factor (IGF) axis also influences cancer risk.

Methods: In this commentary, we consider the literature on IGF and its binding proteins and the risk of breast cancer, along with effects of obesity, adipokines, and insulin resistance on breast cancer, and the potential for lifestyle interventions to address weight gain and physical inactivity among at-risk women. Read More

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http://dx.doi.org/10.5539/cco.v4n2p24DOI Listing
January 2015
23 Reads

Reasons to Use and Disclose Use of Complementary Medicine Use - An Insight from Cancer Patients.

Cancer Clin Oncol 2013 Nov 7;2(2):81-92. Epub 2013 Oct 7.

School of Public Health, Loma Linda University, Loma Linda, CA, USA.

Studies have shown a high prevalence (40-83%) of complementary and alternative medicine (CAM) use among cancer patients in the U.S.A cross-sectional, mixed-methods pilot study was completed. Read More

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http://dx.doi.org/10.5539/cco.v2n2p81DOI Listing
November 2013
4 Reads

Significance of p16 in Site-specific HPV Positive and HPV Negative Head and Neck Squamous Cell Carcinoma.

Cancer Clin Oncol 2013 ;2(1):51-61

Department of Otolaryngology/Head and Neck Research, Henry Ford Hospital, Detroit, USA.

Expression of p16 (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinoma (HNSCC), however, p16-positivity is not limited to HPV positive tumors and therefore, not a perfect surrogate for HPV. p16 survival outcomes are best documented for the oropharyngeal site (OP); non-OP sites such as the oral cavity (OC), larynx, and hypopharynx (HP) are understudied. The goal of this study was to evaluate p16 in the context of HPV16 and examine p16 survival outcomes in HPV16 positive and HPV16 negative site-specific HNSCC. Read More

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http://dx.doi.org/10.5539/cco.v2n1p51DOI Listing
January 2013
5 Reads

Influence of Alternative Tubulin Inhibitors on the Potency of a Epirubicin-Immunochemotherapeutic Synthesized with an Ultra Violet Light-Activated Intermediate: Influence of incorporating an internal/integral disulfide bond structure and Alternative Tubulin/Microtubule Inhibitors on the Cytotoxic Anti-Neoplastic Potency of Epirubicin-(C-amide)-Anti-HER2/neu Synthesized Utilizing a UV-Photoactivated Anthracycline Intermediate.

Cancer Clin Oncol 2012 Nov;1(2):49-80

College of Veterinary Medicine, Mississippi State University, USA.

Immunochemotherapeutics, epirubicin-(C-)-SS-[anti-HER2/] with an internal disulfide bond, and epirubicin-(C-)-[anti-HER2/] were synthesized utilizing succinimidyl 2-[(4,4'-azipentanamido) ethyl]-1,3'-dithioproprionate or succinimidyl 4,4-azipentanoate respectively. Western blot analysis was used to determine the presence of any immunoglobulin fragmentation or IgG-IgG polymerization. Retained HER2/ binding characteristics of epirubicin-(C-)-[anti-HER2/] and epirubicin-(C-)-SS-[anti-HER2/] were validated by cell-ELISA using a mammary adenocarcinoma (SKBr-3) population that highly over-expresses trophic HER2/ receptor complexes. Read More

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http://dx.doi.org/10.5539/cco.v1n2p49DOI Listing
November 2012
1 Read

Cardiorespiratory Fitness in Women with and without Lymphedema following Breast Cancer Treatment.

Cancer Clin Oncol 2012 May;1(1):21-31

Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA.

Following breast cancer (BC) treatment, many women develop impairments that may impact cardiorespiratory (CR) fitness. The aims of this study were to 1) evaluate CR fitness in women following BC treatment, 2) evaluate differences in CR fitness in those with and without breast cancer-related lymphedema (BCRL) and compare these to age-matched norms, and 3) evaluate the contribution of predictor variables to CR fitness. 136 women post-BC treatment completed testing: 67 with BCRL, and 69 without. Read More

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http://dx.doi.org/10.5539/cco.v1n1p21DOI Listing
May 2012
3 Reads

Prognosis for Survival of Young Women with Breast Cancer by Quantitative p53 Immunohistochemistry.

Cancer Clin Oncol 2012;1(1):52-64

Department of Radiation Oncology, Robert Wood Johnson Medical School-UMDNJ, Cancer Institute of New Jersey, New Jersey, USA.

p53 protein detected immunohistochemically has not been accepted as a biomarker for breast cancer patients because of disparate reports of the relationship between the amount of p53 protein detected and patient survival. The purpose of this study was to determine experimental conditions and methods of data analysis for which p53 stain intensity could be prognostic for survival of young breast cancer patients. A tissue microarray of specimens from 93 patients was stained with anti-p53 antibody, and stain intensity measured with a computer-aided image analysis system. Read More

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http://dx.doi.org/10.5539/cco.v1n1p52DOI Listing
January 2012
10 Reads
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