33,854 results match your criteria Cancer and Rehabilitation


High-risk cytogenetics in multiple myeloma: Further scrutiny of deletions within the IGH gene region enhances risk stratification.

Genes Chromosomes Cancer 2020 May 24. Epub 2020 May 24.

Human Genetics Laboratory, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska.

Multiple myeloma is a clonal malignancy of plasma cells in the bone marrow. Risk stratification is partly based on cytogenetic findings that include abnormalities of the IGH locus as determined by fluorescence in situ hybridization (FISH), such as rearrangements that result in either standard-risk or high-risk gene fusions. IGH deletions have been evaluated as a group in multiple myeloma patients with respect to cumulative outcomes but have provided limited guidance. Read More

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http://dx.doi.org/10.1002/gcc.22874DOI Listing

Feasibility of eccentric overloading and neuromuscular electrical stimulation to improve muscle strength and muscle mass after treatment for head and neck cancer.

J Cancer Surviv 2020 May 24. Epub 2020 May 24.

Faculty of Kinesiology, University of Calgary, Calgary, Canada.

Purpose: Treatment of head and neck cancer (HNC) results in severe weight loss, mainly due to the loss of lean body mass. Consequently, decreases in muscular strength and health-related quality of life (HRQL) occur. This study investigated the feasibility of a 12-week novel strength training (NST) and conventional strength training (CST) intervention delivered after HNC treatment. Read More

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http://dx.doi.org/10.1007/s11764-020-00893-9DOI Listing

An Integrative Framework of Appraisal and Adaptation in Serious Medical Illness.

J Pain Symptom Manage 2020 May 21. Epub 2020 May 21.

Associate Professor of Psychology, Harvard Medical School, Program Director, Center for Psychiatric Oncology & Behavioral Science, Co-Director, Cancer Outcomes Research & Education Program, Massachusetts General Hospital Cancer Center, Boston, MA, USA.

Multiple randomized clinical trials have demonstrated that palliative care improves the quality of life of individuals with serious medical illness. Research also suggests that in patients with advanced cancer, palliative care's focus on symptom management, coping with illness, goals of care, and treatment decisions may be associated with improved patient quality of life in part by increasing patients' use of active (versus passive) and approach-oriented (versus avoidant) coping strategies. However, without a framework outlining the process that individuals with serious medical illness and their loved ones undergo, it is challenging to discern exactly where, how, and why palliative care may affect the serious medical illness experience. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.05.018DOI Listing

An existential support program for people with cancer: Development and qualitative evaluation.

Eur J Oncol Nurs 2020 May 13;46:101768. Epub 2020 May 13.

Department of Psychology, University of Southern Denmark, Odense M, Denmark.

Purpose: To describe the development process of an existential support program and to explore participants' evaluation of supportive/unsupportive processes of change.

Method: A five-day existential support program called "Energy for life" was designed including three main elements: 1. existential group counseling, 2. Read More

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http://dx.doi.org/10.1016/j.ejon.2020.101768DOI Listing

ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats.

Exp Neurol 2020 May 20:113362. Epub 2020 May 20.

Department of Laboratory Medicine, Chongqing University Cancer Hospital, Chongqing, China. Electronic address:

Background And Purpose: The present study was designed to investigate the potential role and the mechanism of equilibrative nucleoside transporter 1 (ENT1) on neuronal apoptosis and neurological deficits after middle cerebral artery occlusion (MCAO) in rats.

Methods: One hundred and thirty-four male Sprague-Dawley rats were subjected to two hours of MCAO followed by reperfusion. The time course of the expression level of ENT1 and phosphorylation of CREB were detected by western blot and immunofluorescence staining. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113362DOI Listing

Antibacterial prophylaxis of febrile neutropenia is not effective in the pre-engraftment period in pediatric allogeneic hematopoietic stem cell transplantation.

Transpl Infect Dis 2020 May 23:e13340. Epub 2020 May 23.

Infectious Diseases Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy.

the recently published guideline by Lehrnbecher et al [1] on antibacterial prophylaxis for prevention of febrile neutropenia in cancer children gives a weak recommendation with a moderate quality evidence not to administer systemic antibacterial prophylaxis for children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). This recommendation was based mainly on a single randomized clinical trial [2], showing no effectiveness of levofloxacin compared to no prophylaxis (effectiveness 11.0% vs 17. Read More

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http://dx.doi.org/10.1111/tid.13340DOI Listing

Eat All Through Radiation Therapy (EAT-RT): Structured therapy model to facilitate continued oral intake through head and neck radiotherapy-User acceptance and content validation.

Head Neck 2020 May 23. Epub 2020 May 23.

Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Background: To develop and examine user acceptance and content validity of a structured program to facilitate safe but challenging oral intake during radiotherapy (RT) delivered by a speech language pathologist (SLP)-the Eat-All Through Radiation Therapy (EAT-RT) program.

Methods: EAT-RT was developed through expert consensus of SLPs at the Princess Margaret Cancer Centre (Canada) and M D Anderson Cancer Center using a conceptual framework of a diet hierarchy and a mealtime routine. EAT-RT was refined by practicing SLPs, and then disseminated for a 4-week clinical pilot at seven sites who were subsequently invited to participate in an online survey. Read More

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http://dx.doi.org/10.1002/hed.26250DOI Listing

Heat and moisture exchanger cassettes: Results of a quality/safety initiative to reduce postoperative mucus plugging after total laryngectomy.

Head Neck 2020 May 23. Epub 2020 May 23.

Department of Otolaryngology-Head and Neck Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

Background: Tracheal dryness is a concern after total laryngectomy due to the potential for mucus plugs (MP). This study compared heat and moisture exchanger (HME) cassettes to external tracheal humidification (ETH) surrounding MP events.

Methods: A retrospective comparative cohort study comparing outcomes before/after implementation of a patient safety initiative utilizing HME during post laryngectomy hospitalization. Read More

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http://dx.doi.org/10.1002/hed.26267DOI Listing

Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol.

Pediatrics 2020 May 22. Epub 2020 May 22.

Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

The use of cannabidiol products in pediatric patients is becoming more frequent because of the increased ease of accessibility. This case report illustrates the potential for cannabidiol to interact with stable medication regimens. A 13-year-old girl with metastatic cancer and chronic pain presented with increased sleepiness and fatigue. Read More

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http://dx.doi.org/10.1542/peds.2019-3256DOI Listing

Relationship between Performance on the Mini-Mental State Examination Sub-Items and Activities of Daily Living in Patients with Alzheimer's Disease.

J Clin Med 2020 May 20;9(5). Epub 2020 May 20.

Department of Clinical Neuropsychiatry, Graduate School of Health Sciences, Kagoshima University, Kagoshima 890-8544, Japan.

Mini-mental state examination (MMSE) subitems provide useful information about the cognitive status of patients with Alzheimer's disease (AD). If the relationship between MMSE subitems and activities of daily living (ADL) can be shown, the performance of sub-items can predict ADL status and may provide useful information for early ADL intervention. Therefore, the purpose of this study was to investigate the relationship between MMSE subitem scores and ADL. Read More

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http://dx.doi.org/10.3390/jcm9051537DOI Listing

[Multiple insufficiency fractures (metatarsial, calcaneal and sacral) as the first manifestation of lung adenocarcinoma. A case report and literature review].

Rehabilitacion (Madr) 2020 Jan 6. Epub 2020 Jan 6.

Servicio de Rehabilitación y Medicina Física, Hospital Universitario Santa Cristina, Madrid, España.

Insufficiency fractures, or pathological fractures, are produced after minimal trauma or no prior trauma and normally affect weakened bone. Their presence should be suspected in fractures showing abnormal patterns, when several fractures occur in a short period of time and in those with no apparent or only minimal trauma. On confirmation of an insufficiency fracture, a differential diagnosis should be made between tumoral and metastatic fractures if there is a history of underlying primary malignancy. Read More

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http://dx.doi.org/10.1016/j.rh.2019.11.002DOI Listing
January 2020

Cancer Pain Management: An Italian Delphi Survey from the Rational Use of Analgesics (RUA) Group.

J Pain Res 2020 8;13:979-986. Epub 2020 May 8.

Azienda Ospedaliera Salvini, Garbagnate Milanese, Italy.

Background: In patients with cancer, the prevalence of pain is high, and pain management is often challenging despite the wide availability of drugs and guidelines.

Methods: This Delphi survey was organized within the Rational Use of Analgesics (RUA) Group projects to reach a consensus among Italian palliative care specialists on pain assessment and management. Items were identified from recent publications on cancer pain and guidelines. Read More

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http://dx.doi.org/10.2147/JPR.S243222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217311PMC

Dental Rehabilitation of a Child with Acute Lymphocytic Leukemia: A Case Report.

Int J Clin Pediatr Dent 2019 Nov-Dec;12(6):582-586

Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Leukemia is the cancer of blood cells and bone marrow and it is the most common cancer in children. The cause of acute lymphocytic leukemia is unknown, but many predisposing risk factors could be associated, such as an exposure to radiation, chemical or viral infections. A six-year-old boy was presented with multiple carious teeth and severe pain related to his lower left teeth. Read More

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http://dx.doi.org/10.5005/jp-journals-10005-1664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229377PMC

Childhood central nervous system tumors and leukemia: Incidence and familial risk. A comparative population-based study in Utah and Norway.

Pediatr Blood Cancer 2020 May 21:e28408. Epub 2020 May 21.

Institute of Health and Society, University of Oslo, Oslo, Norway.

Background: In this study, we aimed to evaluate incidence rates and family risk of the most common childhood cancers, tumors in the central nervous system (CNS), and leukemia among individuals from Norway and individuals with Scandinavian ancestry living in Utah.

Methods: We used the Utah Population Database and the Norwegian National Population Register linked to Cancer registries to identify cancers in children born between 1966 and 2015 and their first-degree relatives. We calculated incidence rates and hazards ratios. Read More

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http://dx.doi.org/10.1002/pbc.28408DOI Listing

Curcumin alleviates OGD/R-induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF-κB to suppress inflammation and apoptosis.

J Pharm Pharmacol 2020 May 21. Epub 2020 May 21.

Department of Rehabilitation, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Objectives: Curcumin presents some therapeutic effects including anti-cancer and anti-inflammation. Herein, we centred on the functional role of curcumin in cerebral ischaemia injury and its potential molecular mechanisms.

Methods: Microarray analysis was used for excavating crucial genes in cerebral ischaemia. Read More

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http://dx.doi.org/10.1111/jphp.13293DOI Listing

Fluoropyrimidine-Associated Cardiotoxicity: Probably Not So Rare As It Seems.

Oncologist 2020 May 20. Epub 2020 May 20.

Oncology Department, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, IRCCS, Aviano, Italy.

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http://dx.doi.org/10.1634/theoncologist.2020-0053DOI Listing

Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma.

Clin Exp Metastasis 2020 May 20. Epub 2020 May 20.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Soft tissue sarcomas (STSs) are rare heterogeneous malignancies of mesenchymal origin. Pulmonary metastases develop in approximately 50% of the patients with high-grade STS, being the major cause of mortality in patients with metastatic STS. Pulmonary metastasectomy has been reported to contribute to long-term survival; however, an appropriate treatment has not been established. Read More

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http://dx.doi.org/10.1007/s10585-020-10038-yDOI Listing

Impact of the ENSP eLearning platform on improving knowledge, attitudes and self-efficacy for treating tobacco dependence: An assessment across 15 European countries.

Tob Induc Dis 2020 7;18:40. Epub 2020 May 7.

European Network for Smoking and Tobacco Prevention, Brussels, Belgium.

Introduction: In 2018, the European Network for Smoking Cessation and Prevention (ENSP) released an update to its Tobacco Treatment Guidelines for healthcare professionals, which was the scientific base for the development of an accredited eLearning curriculum to train healthcare professionals, available in 14 languages. The aim of this study was to evaluate the effectiveness of ENSP eLearning curriculum in increasing healthcare professionals' knowledge, attitudes, self-efficacy (perceived behavioral control) and intentions in delivering tobacco treatment interventions in their daily clinical routines.

Methods: We conducted a quasi-experimental pre-post design study with 444 healthcare professionals, invited by 20 collaborating institutions from 15 countries (Albania, Armenia, Belgium, Italy, France, Georgia, Greece, Kosovo, Romania, North Macedonia, Russia, Serbia, Slovenia, Spain, Ukraine), which completed the eLearning course between December 2018 and July 2019. Read More

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http://dx.doi.org/10.18332/tid/120188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233524PMC

Rising to the challenge: designing, implementing and reporting exercise oncology trials in understudied populations.

Br J Cancer 2020 May 21. Epub 2020 May 21.

Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.

Exercise can improve cancer-related fatigue, quality of life and physical fitness, but is understudied in less common cancers such as multiple myeloma. Studying less common cancers and the adoption of novel study designs and open-science practices would improve the generalisability, transparency, rigour, credibility and reproducibility of exercise oncology research. Read More

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http://dx.doi.org/10.1038/s41416-020-0868-9DOI Listing

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function.

JCI Insight 2020 May 21;5(10). Epub 2020 May 21.

Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.

NOD-like receptor 12 (NLRP12) is a member of the nucleotide-binding domain and leucine-rich repeat containing receptor inflammasome family that plays a central role in innate immunity. We previously showed that DNA damage upregulated NLRP12 in hematopoietic stem cells (HSCs) of mice deficient in the DNA repair gene Fanca. However, the role of NLRP12 in HSC maintenance is not known. Read More

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http://dx.doi.org/10.1172/jci.insight.133365DOI Listing

Disparities in Ocular and Periocular Cancer Outcomes: Assessing Survival in Patients of Hispanic Origin.

Cureus 2020 Apr 17;12(4):e7713. Epub 2020 Apr 17.

Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch at Galveston, Galveston, USA.

A nationwide cancer database was used to perform a retrospective cohort study to compare the overall survival and cause-specific survival in patients with ocular and periocular cancer from varying Hispanic origins. A total of 19,831 cases from the Surveillance, Epidemiology, and End Results (SEER) registries between 1973 and 2015 were obtained for analysis. All-cause and cause-specific mortality risk, with adjustment for age group, sex, race, tumor site, tumor histology, grade, summary stage, laterality, surgery status, radiotherapy status, and chemotherapy status, was examined using Cox proportional hazard models. Read More

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http://dx.doi.org/10.7759/cureus.7713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233504PMC

Methylation Analysis of and in Circulating Cell-Free DNA for Detection of Gastric Cancer: A Validation Study.

Avicenna J Med Biotechnol 2020 Apr-Jun;12(2):99-106

Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Most of Gastric Cancer (GC) patients are diagnosed at an advanced stage with poor prognosis. Hypermethylations of several tumor suppressor genes in cell-free DNA of GC patients have been previously reported. In this study, an attempt was made to investigate the methylation status of and and their potentials for early diagnosis of GC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229449PMC

Measuring upper limb function and patient reported outcomes after major breast cancer surgery: a pilot study in an Asian cohort.

BMC Surg 2020 May 19;20(1):108. Epub 2020 May 19.

Department of General Surgery, Khoo Teck Puat Hospital, Singapore, Singapore.

Background: Breast cancer is the most common cancer in women worldwide. Major breast cancer surgery especially with axillary lymph node dissection (ALND), is associated with upper limb functional decline. Majority of studies are conducted in Western population and may not be applicable to Asians. Read More

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http://dx.doi.org/10.1186/s12893-020-00773-0DOI Listing

[Intraoperative Aspiration].

Authors:
Yiyao Cui Yong Cui

Zhongguo Fei Ai Za Zhi 2020 May;23(5):393-401

Department of Thoracic Surgery, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China.

Intraoperative aspiration is a common pulmonary complication in the surgery, anesthesia and position were main factors leading to the operative aspiration. In recent years, perioperative lung protection has attracted wide attention of thoracic surgeons and anesthetist; how to accelerate the process of postoperative rehabilitation, reduce the incidence of related complications and significantly improve the prognosis of patients, these have become a chief goal of surgical treatment. This article will center on operative aspiration and summarize it from anatomy, pathophysiology, manifestation, diagnosis, treatment and prevention. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2020.101.22DOI Listing

Dynamical network analysis reveals key microRNAs in progressive stages of lung cancer.

PLoS Comput Biol 2020 May 19;16(5):e1007793. Epub 2020 May 19.

School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, United States of America.

Non-coding RNAs are fundamental to the competing endogenous RNA (CeRNA) hypothesis in oncology. Previous work focused on static CeRNA networks. We construct and analyze CeRNA networks for four sequential stages of lung adenocarcinoma (LUAD) based on multi-omics data of long non-coding RNAs (lncRNAs), microRNAs and mRNAs. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007793DOI Listing

Neck Disability and Swallowing Function in Posttreatment Head and Neck Cancer Patients.

Otolaryngol Head Neck Surg 2020 May 19:194599820923630. Epub 2020 May 19.

Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Objective: To examine the relationship between symptoms of neck disability and swallowing dysfunction among head and neck cancer (HNC) survivors.

Study Design: Cross-sectional analysis.

Setting: Single-center, university-affiliated HNC survivorship clinic. Read More

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http://dx.doi.org/10.1177/0194599820923630DOI Listing

Cancer patients' preferred and perceived level of involvement in treatment decision-making: an epidemiological study.

Acta Oncol 2020 May 19:1-8. Epub 2020 May 19.

Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

We aimed to analyze preferred and perceived levels of patients' involvement in treatment decision-making in a representative sample of cancer patients. We conducted a multicenter, epidemiological cross-sectional study with a stratified random sample based on the incidence of cancer diagnoses in Germany. Data were collected between January 2008 and December 2010. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1762926DOI Listing

Dysphagia after chemo-radiation for nasopharyngeal cancer: A scoping review.

World J Otorhinolaryngol Head Neck Surg 2020 Mar 10;6(1):10-24. Epub 2020 Apr 10.

The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Queensland, Australia.

Objective: Nasopharyngeal cancer (NPC) has distinct characteristics regarding its global prevalence, initial presentation, management and patient outcomes compared to other subtypes of head and neck cancer (HNC). The mainstay of NPC treatment is chemo-radiation (C/RT) and while dysphagia is a known early and late toxicity of C/RT treatment, the nature of dysphagia post NPC treatment has had limited investigation. The objective of this review is to summarise the existing evidence regarding dysphagia following NPC to inform the future research agenda for this population. Read More

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http://dx.doi.org/10.1016/j.wjorl.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221212PMC

Patients perceptions of virtual reality therapy in the management of chronic cancer pain.

Heliyon 2020 May 12;6(5):e03916. Epub 2020 May 12.

School of Nursing, University of British Columbia, BC, Canada.

The management of chronic cancer pain remains challenging and complex, with the process often involving a variety of pharmacological and non-pharmacological approaches. Recent studies have shown virtual reality (VR) therapy to be successful in the management of acute pain. However, it remains unclear whether VR-based applications are effective as an adjunctive therapy for cancer patients with chronic pain. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226660PMC

Death of the ALARA Radiation Protection Principle as Used in the Medical Sector.

Dose Response 2020 Apr-Jun;18(2):1559325820921641. Epub 2020 Apr 29.

CBP NonProfit, Inc, Eagle, ID, USA.

ALARA is the acronym for "As Low As Reasonably Achievable." It is a radiation protection concept borne from the linear no-threshold (LNT) hypothesis. There are no valid data today supporting the use of LNT in the low-dose range, so dose as a surrogate for risk in radiological imaging is not appropriate, and therefore, the use of the ALARA concept is obsolete. Read More

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http://dx.doi.org/10.1177/1559325820921641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218317PMC

Are Restrictive Medical Radiation Imaging Campaigns Misguided? It Seems So: A Case Example of the American Chiropractic Association's Adoption of "Choosing Wisely".

Dose Response 2020 Apr-Jun;18(2):1559325820919321. Epub 2020 May 1.

CBP NonProfit, Inc, Eagle, ID, USA.

Since the 1980s, increased utilization of medical radiology, primarily computed tomography, has doubled medically sourced radiation exposures. Ensuing fear-mongering media headlines of iatrogenic cancers from these essential medical diagnostic tools has led the public and medical professionals alike to display escalating radiophobia. Problematically, several campaigns including Image Gently, Image Wisely, and facets of Choosing Wisely propagate fears of all medical radiation, which is necessary for the delivery of effective and efficient health care. Read More

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http://dx.doi.org/10.1177/1559325820919321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218311PMC

Intensity- and domain-specific physical activity levels between cancer survivors and non-cancer diagnosis individuals: a propensity score matching analysis.

Support Care Cancer 2020 May 19. Epub 2020 May 19.

Department of Sport Industry Studies, Exercise Medicine and Rehabilitation Laboratory, Yonsei University, Seoul, Republic of Korea.

Purpose: To examine intensity- and domain-specific physical activity (PA) levels between Korean cancer survivors compared with non-cancer individuals.

Methods: We used data from the 2014-2016 Korean National Health and Nutrition Examination Survey (KNHNES) to compare PA levels between 639 cancer survivors and 15,352 non-cancer individuals. Using the 1:5 propensity score matching analysis by sex, age, body mass index (BMI), and education level, 3195 non-cancer individuals were selected. Read More

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http://dx.doi.org/10.1007/s00520-020-05514-wDOI Listing

The long-term course of fatigue following breast cancer diagnosis.

J Patient Rep Outcomes 2020 May 18;4(1):37. Epub 2020 May 18.

AmbuFlex/WestChronic, Occupational Medicine, University Research Clinic, Regional Hospital West Jutland, Herning, Denmark.

Purpose: Fatigue following breast cancer is a well-known problem, with both high and persistent prevalence. Previous studies suffer from lack of repeated measurements, late recruitment and short periods of follow-up. The course of fatigue from diagnosis and treatment to the long-time outcome status is unknown as well as differences in the level of fatigue between treatment regimens. Read More

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http://dx.doi.org/10.1186/s41687-020-00187-9DOI Listing

Borderline ovarian tumours: management in the era of fertility-sparing surgery.

Ecancermedicalscience 2020 6;14:1031. Epub 2020 May 6.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Italy.

Borderline ovarian tumours (BOTs) are ovarian neoplasms characterised by epithelial proliferation, variable nuclear atypia and no evidence of destructive stromal invasion. BOTs account for approximately 15% of all epithelial ovarian cancers. Due to the fact that the majority of BOTs occur in women under 40 years of age, their surgical management often has to consider fertility-sparing approaches. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221127PMC

Nonhormonal Hot Flash Management for Breast Cancer Survivors: A Systematic Review and Network Meta-Analysis.

Evid Based Complement Alternat Med 2020 28;2020:4243175. Epub 2020 Apr 28.

Department of Gynecology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Dade Road, Yuexiu District, Guangzhou 510120, Guangdong, China.

Materials And Methods: We conducted a systematic literature search in PubMed, Cochrane Central Register of Controlled Trials, Embase, Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), Wan Fang, and VIP up to May 2018. Randomized controlled trials (RCTs) reporting nonhormonal hot flash treatments for breast cancer survivors were included. Primary outcome measurements were hot flash frequency and hot flash score of posttreatment. Read More

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http://dx.doi.org/10.1155/2020/4243175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204350PMC

Pelvic Floor Muscle Training and Erectile Dysfunction in Radical Prostatectomy: A Randomized Controlled Trial Investigating a Non-Invasive Addition to Penile Rehabilitation.

Sex Med 2020 May 14. Epub 2020 May 14.

School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Crawley, Western Australia.

Introduction: Pelvic floor muscle (PFM) training for postprostatectomy incontinence is considered a first line approach to rehabilitation, but PFM training for erectile dysfunction (ED) after surgery is less well known. With more than 1.4 million new cases diagnosed globally per year, there is a need for non-invasive options to assist sexual dysfunction recovery. Read More

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http://dx.doi.org/10.1016/j.esxm.2020.03.005DOI Listing

LncRNA DCST1-AS1 downregulates miR-29b through methylation in glioblastoma (GBM) to promote cancer cell proliferation.

Authors:
S Hu Y Yao X Hu Y Zhu

Clin Transl Oncol 2020 May 16. Epub 2020 May 16.

Department of Rehabilitation, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, No. 141 Tianjin Road, Huangshi Gang District, Huangshi City, 435000, Hubei Province, People's Republic of China.

Introduction: The role of DCST1-AS1 has been investigated in several types of cancer, while the role of DCST1-AS1 in glioblastoma (GBM) is unclear. This study aimed to investigate the role of DCST1-AS1 in GBM.

Methods: GBM and paired non-tumor tissues were collected from 62 GBM patients. Read More

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http://dx.doi.org/10.1007/s12094-020-02363-1DOI Listing

Mesenchymal stromal cells in adipose tissue of breast cancer patients: a cross-sectional study.

Cell Mol Biol (Noisy-le-grand) 2020 May 15;66(2):71-73. Epub 2020 May 15.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Mesenchymal stromal cells (MSCs) are important components of the tumor microenvironment and are believed to facilitate cancer growth affecting cancer cells. We investigated this issue in breast cancer patients. In this cross-sectional study biopsy or mastectomy specimens from breast cancer patients who underwent surgery were evaluated based on the presence of MSCs. Read More

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Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.

Support Care Cancer 2020 May 15. Epub 2020 May 15.

Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: The purpose of this systematic review update and meta-analysis was to analyze resistance exercise (RE) intervention trials in breast cancer survivors (BCS) regarding their effect on breast cancer-related lymphedema (BCRL) status and upper and lower extremity strength.

Methods: Systematic literature search was conducted utilizing PubMed, MEDLINE, and Embase databases. Any exercise intervention studies-both randomized controlled and uncontrolled-which assessed the effects of RE on BCRL in BCS in at least one intervention group published between 1966 and 31st January 2020 were included. Read More

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http://dx.doi.org/10.1007/s00520-020-05521-xDOI Listing

The Needs and Experiences of Post-Treatment Adolescent and Young Adult Cancer Survivors.

J Clin Med 2020 May 13;9(5). Epub 2020 May 13.

Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.

(1) Background: Adolescents and young adults (AYAs) who have been diagnosed with and treated for cancer have unique healthcare needs, but more research is needed to inform developmentally targeted cancer care for this population. The purpose of the current analyses was to describe the physical and psychosocial concerns and experiences of AYA cancer survivors during the post-treatment phase. (2) Methods: A national survey was conducted by the Canadian Partnership Against Cancer to evaluate the experiences and unmet needs of cancer survivors (≥18 years) within the first 5 years following cancer treatment. Read More

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http://dx.doi.org/10.3390/jcm9051444DOI Listing

Guidelines for TMS/tES Clinical Services and Research through the COVID-19 Pandemic.

Brain Stimul 2020 May 12. Epub 2020 May 12.

Laureate Institute for Brain Research, Tulsa, OK, USA. Electronic address:

Background: The COVID-19 pandemic has broadly disrupted biomedical treatment and research including non-invasive brain stimulation (NIBS). Moreover, the rapid onset of societal disruption and evolving regulatory restrictions may not have allowed for systematic planning of how clinical and research work may continue throughout the pandemic or be restarted as restrictions are abated. The urgency to provide and develop NIBS as an intervention for diverse neurological and mental health indications, and as a catalyst of fundamental brain research, is not dampened by the parallel efforts to address the most life-threatening aspects of COVID-19; rather in many cases the need for NIBS is heightened including the potential to mitigate mental health consequences related to COVID-19. Read More

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http://dx.doi.org/10.1016/j.brs.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217075PMC

Analyzing the prognostic value of DKK1 expression in human cancers based on bioinformatics.

Ann Transl Med 2020 Apr;8(8):552

Department of Rehabilitation Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Background: The Dickkopf1 () gene encodes a protein that belongs to the Dickkopf family. The protein can inhibit the Wnt signaling pathway which plays a key role in the carcinogenesis and progression of various types of cancers. Based on this, we hypothesized that the differential expression of DKK1 may figure significantly in cancers by regulating Wnt signaling pathway transduction. Read More

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http://dx.doi.org/10.21037/atm-20-3263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214893PMC

High Density Lipoprotein and Its Precursor Protein Apolipoprotein A1 as Potential Therapeutics to Prevent Anthracycline Associated Cardiotoxicity.

Front Cardiovasc Med 2020 28;7:65. Epub 2020 Apr 28.

Department of Biochemistry and Biomedical Sciences, Thrombosis and Atherosclerosis Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

Cardiovascular disease and cancer are the leading causes of death in developed societies. Despite their effectiveness, many cancer therapies exhibit deleterious cardiovascular side effects such as cardiotoxicity and heart failure. The cardiotoxic effects of anthracyclines such as doxorubicin are the most well-characterized of cardiotoxic anti-cancer therapies. Read More

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http://dx.doi.org/10.3389/fcvm.2020.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198830PMC

Reliability and validity of a Dutch Lymphoedema Questionnaire: Cross-cultural validation of the Norman Questionnaire.

Eur J Cancer Care (Engl) 2020 May 15:e13242. Epub 2020 May 15.

Department of Rehabilitation Sciences, KU Leuven - University of Leuven, Leuven, Belgium.

Objective: To perform the cross-cultural validation process of the Dutch Norman Questionnaire (NQ), a questionnaire for the detection and characterisation of breast-cancer related lymphoedema (BCRL) using self-reported signs and symptoms.

Methods: Test-retest reliability and construct (including convergent, divergent and known-groups validity), face and content validity were examined in breast cancer patients with (n = 30) and without (n = 30) lymphoedema. For concurrent validity, first, agreement between the diagnostic item of the NQ and a clinical diagnosis were analysed. Read More

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http://dx.doi.org/10.1111/ecc.13242DOI Listing

Pilot Study of Quantitative Methods for Differentiating Pharyngeal Swallowing Mechanics by Dysphagia Etiology.

Dysphagia 2020 May 14. Epub 2020 May 14.

Department of Cellular Biology and Anatomy, MCG, Augusta University, Augusta, Georgia.

Quantitative analysis of modified barium swallow (MBS) imaging is useful to determine the impact of various disease states on pharyngeal swallowing mechanics. In this retrospective proof of concept study, kinematic analysis and computational analysis of swallowing mechanics (CASM) were used to demonstrate how these methods differentiate swallowing dysfunction by dysphagia etiology. Ten subjects were randomly selected from four cohorts of dysphagic patients including COPD, head and neck cancer (HNC), motor neuron disease, and stroke. Read More

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http://dx.doi.org/10.1007/s00455-020-10123-0DOI Listing

A Survey on Physical and Mental Distress among Cancer Patients during the COVID-19 Epidemic in Wuhan, China.

J Palliat Med 2020 May 14. Epub 2020 May 14.

Department of Radiation Oncology, Tongji Medical College, Huazhong University of Science and Technology, Hubei Cancer Hospital, Wuhan, Hubei, China.

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http://dx.doi.org/10.1089/jpm.2020.0240DOI Listing

The Wildman Programme. A Nature-Based Rehabilitation Programme Enhancing Quality of Life for Men on Long-Term Sick Leave: Study Protocol for a Matched Controlled Study In Denmark.

Int J Environ Res Public Health 2020 May 12;17(10). Epub 2020 May 12.

Department of Psychology, University of Southern Denmark, 5230 Odense M, Denmark.

Many men have poor mental health and need help to recover. However, designing a rehabilitation intervention that appeals to men is challenging. This study protocol aims to describe the 'Wildman Programme', which will be a nature-based rehabilitation programme for men on long-term sick leave due to health problems such as stress, anxiety, depression, post-cancer and chronic cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease, or diabetes type II. Read More

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http://dx.doi.org/10.3390/ijerph17103368DOI Listing

Shortlist of Quality Indicators for End-of-Life Cancer Care-Reply.

JAMA Oncol 2020 May 14. Epub 2020 May 14.

Cicely Saunders Institute of Palliative Care, Policy & Rehabilitation, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaoncol.2020.1162DOI Listing

Myotonia congenita and periodic hypokalemia paralysis in a consanguineous marriage pedigree: Coexistence of a novel CLCN1 mutation and an SCN4A mutation.

PLoS One 2020 14;15(5):e0233017. Epub 2020 May 14.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Myotonia congenita and hypokalemic periodic paralysis type 2 are both rare genetic channelopathies caused by mutations in the CLCN1 gene encoding voltage-gated chloride channel CLC-1 and the SCN4A gene encoding voltage-gated sodium channel Nav1.4. The patients with concomitant mutations in both genes manifested different unique symptoms from mutations in these genes separately. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233017PLOS