Search Our Scientific Publications & Authors

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Context: The use of a handheld or electric fan has been proposed as one component of the complex clinical interventions used in the relief of dyspnea; however, there is a lack of consensus regarding its efficacy.

Objectives: We performed a systematic review to determine the effectiveness of fan therapy for the treatment of dyspnea.

Methods: We searched the Medline, EMBASE, Web of Science, Scopus, CINAHL, PsycInfo, and Cochrane Library databases to identify all fan therapy studies published from January 1, 1946 to September 31, 2018. Read More

Respirology 2019 Apr 19. Epub 2019 Apr 19.

Discipline of Physiotherapy, La Trobe University, Melbourne, VIC, Australia.

Pulmonary rehabilitation is a core aspect in the management of patients with chronic respiratory diseases. This paper describes a practical approach to establishing pulmonary rehabilitation for patients with non-COPD diagnoses using examples from the interstitial lung disease (ILD), pulmonary hypertension (PH), bronchiectasis and lung cancer patient populations. Aspects of pulmonary rehabilitation, including the rationale, patient selection, setting of programmes, patient assessment and training components (both exercise and non-exercise aspects), are discussed for these patient groups. Read More

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence associated secretory phenotype (SASP). Biomarkers of cellular senescence have been shown to increase with age and degeneration of human disc tissue. Senescent disc cells in culture recapitulate features associated with age-related disc degeneration, including increased secretion of proinflammatory cytokines, matrix proteases, and fragmentation of matrix proteins. Read More

Support Care Cancer 2019 Apr 17. Epub 2019 Apr 17.

Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

Purpose: The implementation of a new online conference tool, with the goal of providing competent answers, information, and support from experts in their fields, about diagnosis, treatment, and rehabilitation in breast cancer patients.

Methods: The implementation process and data of the first online conference are described.

Results: Following the idea and initiative of a breast cancer survivor, and under the umbrella of a leading oncologist in breast cancer treatment, and with the cooperation of further leading experts in the fields, plus their therapeutic teams, the new online conference SURVIVA 2018 was implemented as an innovative platform-free of charge, online, and with easy and anonymous access-to provide breast cancer survivors with in-depth information and help from the leading Austrian experts in their fields. Read More

Eur J Breast Health 2019 Apr 15;15(2):111-118. Epub 2019 Feb 15.

Division of Pain Medicine, Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, İstanbul, Turkey.

Objective: The aim the study is to assess relationships between caregiver burden, quality of life, arm disability, grip strength, and lymphedema symptoms in women with postmastectomy lymphedema.

Materials And Methods: Fifty-two patients with postmastectomy lymphedema were recruited. Burden Interview, Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire and European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-30 and EORTC QLQ BRE-23) were used for the assessments of caregiver burden, arm disability, and quality of life. Read More

Front Pharmacol 2019 29;10:285. Epub 2019 Mar 29.

School of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai, China.

The first-line chemotherapy drug adriamycin (ADM) is widely used for the treatment of breast cancer, but the acquired drug resistance and the normal tissue toxicity remain clinical challenges. Alteronol has been reported to exert wide-ranging anti-tumor activity. In this study, we firstly examined the synergistic anti-tumor effects and the underlying mechanisms of alteronol combined with ADM in breast cancer. Read More

Physiotherapy 2019 Jan 11. Epub 2019 Jan 11.

Department of Thoracic Surgery, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham B9 5SS, UK. Electronic address:

Objectives: Following major thoracic surgery physiotherapy is recommended to improve reduced lung volume, aid secretion clearance, and improve mobility, however, in many centres physiotherapy provision is variable following minimally invasive video-assisted thoracoscopic surgery (VATS). The objective of this study was to observe frequency of problems potentially amenable to physiotherapy following VATS lobectomy, and to identify associated baseline factors of patients in whom physiotherapy may be beneficial.

Methods: A prospective observational study was performed including all consecutive cancer patients undergoing VATS lobectomy in a regional centre over 4years (2012-2016). Read More

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Integrated Cardiovascular Exercise Physiology and Rehabilitation Laboratory, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington.

Importance: Astronauts on International Space Station missions demonstrate adverse neuro-ocular changes. Reversing a negative translaminar pressure gradient (TLPG) by modulating cerebral blood flow, decreasing intracranial pressure, or increasing intraocular pressure (IOP) has been proposed as potential intervention for spaceflight-associated neuro-ocular syndrome (SANS).

Objective: To examine whether exercise (resistance, moderate-intensity aerobic, and high-intensity aerobic) or artificially increasing IOP is associated with modulated cerebro-ocular hemodynamic and pressure changes during head-down tilt (HDT), an analogue of spaceflight, in healthy adults. Read More

J Health Serv Res Policy 2019 Apr 18:1355819619841647. Epub 2019 Apr 18.

11 Consumer Engagement Officer, Cochrane Consumer Network, UK.

Objectives: Involvement of patients, health professionals, and the wider public ('stakeholders') is seen to be beneficial to the quality, relevance and impact of research and may enhance the usefulness and uptake of systematic reviews. However, there is a lack of evidence and resources to guide researchers in how to actively involve stakeholders in systematic reviews. In this paper, we report the development of the ACTIVE framework to describe how stakeholders are involved in systematic reviews. Read More

Breast Cancer Res Treat 2019 Apr 17. Epub 2019 Apr 17.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

Purpose: Treatments for breast cancer can lead to chronic musculoskeletal problems. This study aimed to systematically review the evidence surrounding the cost-effectiveness of exercise and physiotherapy interventions aimed at reducing the risk of physical symptoms and functional limitations due to breast cancer treatment.

Methods: A systematic review of the cost-effectiveness of exercise and physiotherapy interventions during and following treatment for breast cancer was undertaken according to PRISMA guidelines. Read More

Int J Colorectal Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of General Surgery, Gansu Provincial Hospital, Donggang West Road, Lanzhou, 730000, People's Republic of China.

Purpose: The aim of this meta-analysis was to compare high inferior mesenteric artery (IMA) ligation (HL) with low IMA ligation (LL) for the treatment of colorectal cancer and to evaluate the lymph node yield, survival benefit, and safety of these surgeries.

Methods: PubMed, Embase, Cochrane Library, Web of Science, and China Biomedical Literature Database (CBM) were systematically searched for relevant articles that compared HL and LL for sigmoid or rectal cancer. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) for dichotomous outcomes and the weighted mean difference (WMD) for continuous outcomes. Read More

J Immunother Cancer 2019 Apr 17;7(1):107. Epub 2019 Apr 17.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Following publication of the original article [1], the authors reported an error in their listed affiliations. Read More

Nutrients 2019 Apr 16;11(4). Epub 2019 Apr 16.

Section for Nutrition Research, Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Read More

Neurourol Urodyn 2019 Apr 14;38(4):1067-1075. Epub 2019 Mar 14.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Japan.

Aims: To clarify longitudinal change of lower urinary tract symptoms (LUTS) and various types of urinary incontinence following robot-assisted radical prostatectomy (RARP) using validated questionnaires.

Materials And Methods: The core lower urinary tract symptom score (CLSS) and the International Consultation on Incontinence Questionnaire (ICIQ)-Short Form (SF) questionnaires were administered to 607 consecutive, treatment-naïve men receiving RARP before and after surgery. The time course of comprehensive LUTS and various types of urinary incontinence, including stress-, urgency-, and urinary incontinence with no obvious reason, were evaluated. Read More

Lymphat Res Biol 2019 Apr;17(2):141-146

4 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

There is no standardized international model for specialist lymphedema services, which covers the types of lymphedema treated and the treatments provided. The aim of this study was to provide a profile of patients attending specialist lymphedema services in different countries to explore similarities and differences. The LIMPRINT core tool was used in specialist lymphedema services in the United Kingdom, France, Italy, and Turkey. Read More

Lymphat Res Biol 2019 Apr;17(2):202-210

2 Lymphedema Research and Practice Center, Hacettepe University, Ankara, Turkey.

Lymphedema and chronic edema is a major health care problem in both developed and nondeveloped countries The Lymphoedema Impact and Prevelance - International (LIMPRINT) study is an international health service-based study to determine the prevalence and functional impact in adult populations of member countries of the International Lymphoedema Framework (ILF). A total of 1051 patients from eight centers in Turkey were recruited using the LIMPRINT study protocol. Data were collected using the core and module tools that assess the demographic and clinical properties as well as disability and quality of life (QoL). Read More

JMIR Res Protoc 2019 Apr 17;8(4):e12213. Epub 2019 Apr 17.

Center for Palliative Care Research and Education, College of Nursing, University of Florida, Gainesville, FL, United States.

Background: Our goal is to improve psychosocial and spiritual care outcomes for elderly patients with cancer by optimizing an intervention focused on dignity conservation tasks such as settling relationships, sharing words of love, and preparing a legacy document. These tasks are central needs for elderly patients with cancer. Dignity therapy (DT) has clear feasibility but inconsistent efficacy. Read More

Eur J Cancer Care (Engl) 2019 Apr 16:e13048. Epub 2019 Apr 16.

University of Alberta and Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

Cancer-related fatigue (CRF) can be a devastating consequence of cancer and cancer treatments, negatively impacting 50%-90% of cancer patients regardless of age, sex or diagnosis. Limited evidence and research exist to inform effective patient-centred interventions. To target symptom management, there must first be a broader understanding of the symptoms and the lived experience of the persons experiencing CRF and those caring for them, from a supportive as well as a healthcare perspective. Read More

Eur J Cancer Care (Engl) 2019 Apr 16:e13050. Epub 2019 Apr 16.

Department of Rehabilitation Medicine, Catholic Kwandong University International St Mary's Hospital, Incheon, Korea.

To investigate the relation of physical functions to health-related quality of life (HRQOL), physical activity and fatness of patients during breast cancer treatment within 1 year after surgery. We retrospectively reviewed the patients with breast cancer at the cancer rehabilitation clinic within 1 year after surgery. Physical function assessment included aerobic capacity, muscle strength, flexibility and oedema. Read More

J Immunother Cancer 2019 Apr 16;7(1):106. Epub 2019 Apr 16.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Checkpoint inhibitors (CPIs) have revolutionized the treatment of cancer, but their use remains limited by off-target inflammatory and immune-related adverse events. Solid organ transplantation (SOT) recipients have been excluded from clinical trials owing to concerns about alloimmunity, organ rejection, and immunosuppressive therapy. Thus, we conducted a retrospective study and literature review to evaluate the safety of CPIs in patients with cancer and prior SOT. Read More

Nutr Health 2019 Apr 16:260106019841840. Epub 2019 Apr 16.

1 School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO, USA.

Background: The control of chronic inflammation has emerged as a target for improving the health of cancer survivors (CS).

Aim: To examine differences in fitness and dietary characteristics of CS when grouped by low vs. moderate to high serum C-reactive protein (CRP). Read More

Dysphagia 2019 Apr 15. Epub 2019 Apr 15.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, Australia.

At present, the nature and extent of upper esophageal stage clearance issues following nonsurgical management of nasopharyngeal cancer (NPC) is not well elucidated. The aim of this study was to conduct an initial retrospective study of the prevalence and severity of upper esophageal clearance impairments in a cohort of patients post-NPC management. A secondary aim was to explore any observed relationship between severity of impairment with both (a) aspiration and (b) temporal oropharyngeal swallowing measures. Read More

Exp Ther Med 2019 May 18;17(5):3859-3866. Epub 2019 Mar 18.

Department of Orthopaedics, Baoji Central Hospital, Baoji, Shaanxi 721008, P.R. China.

Ginsenoside Rb1 (GRb1) is a major ingredient of ginseng, a traditional medicine that has been used for thousands of years. Previous studies have reported that GRb1 had anti-inflammatory, antioxidant and neuroprotective effects. The current study aimed to evaluate the antinociceptive effects of GRb1 in a rat model of cancer-induced bone pain (CIBP) established by intratibial injection of Walker 256 cells. Read More

Br J Oral Maxillofac Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Oral, Maxillofacial and Facial Plastic Surgery, School of Medicine, University Hospital RWTH Aachen; Aachen, Germany.

After continuity resection of the mandible, reconstruction of continuity with a reconstruction plate and soft tissue can be an alternative to immediate osseous reconstruction in patients with advanced oral cancer. We evaluated exposure of the plate in such reconstructions by comparing the results of a radial forearm flap (RFF) with a vastus lateralis myocutaneous flap (VLMF). We also analysed the resection margins and the incidence of secondary osseous reconstructions after one year free from relapse. Read More

Arthritis Res Ther 2019 Apr 15;21(1):95. Epub 2019 Apr 15.

Division of Rheumatology, University of California in Los Angeles (Emeritus), Los Angeles, USA.

Background/objectives: Systemic sclerosis (SSc) is an autoimmune disease associated with immune abnormalities and widespread vascular lesions, including increased intimal and medial thickness. These changes may be reflected in early atherosclerosis and cardiovascular risks. We aimed in this study to examine the carotid artery intima-media thickness and MRI brain findings in SSc patients and compared them to a group of normal controls. Read More

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Institute for Social Medicine and Epidemiology, University of Lubeck, Lubeck, Germany.

Background: Effective multidisciplinary rehabilitation programs supporting the return to work have become increasingly relevant for cancer survivors. In Germany, inpatient work-related medical rehabilitation programs consider treatment modules of work-related diagnostics, work-related functional capacity training, psychosocial groups, and intensified social counseling. The authors tested the effectiveness of a work-related medical rehabilitation program compared with conventional medical rehabilitation using a cluster-randomized multicenter trial (German Clinical Trial Register: DRKS00007770). Read More

J Laryngol Otol 2019 Mar;133(3):177-182

Department of ENT,Royal Marsden NHS Foundation Trust,London,UK.

Background: It is recognised that a limited cohort of patients receive open partial laryngeal surgery in specific centres within the UK, so sharing information around key clinical issues and recommendations for practice is necessary to improve outcomes.

Methods: This position statement provides practice recommendations based on a synthesis of the available evidence presented at the 12th Evidence Based Management day on 'Laryngeal Cancer' and the ensuing discussions. Literature searches and critical analysis of available evidence were undertaken and triangulated with the clinical experience of the authors to develop these recommendations. Read More

J Thorac Cardiovasc Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Respiratory and Exercise Physiology and CIC-CRB 1404, Rouen University Hospital, Rouen, France.

Objective: Cardiopulmonary exercise testing (CPET) for patients awaiting lung resection for non-small cell lung cancer (NSCLC) has developed considerably in recent years. Pulmonary rehabilitation before surgery (prehabilitation) improves postoperative risk factors such as forced expiratory volume in 1 second and peak oxygen consumption (VO). Ventilatory inefficiency assessed according to the linear regression of the ratio between the increase in minute ventilation and the expired carbon dioxide flow during CPET (VE/VCO slope) >35, is a high-risk factor for postoperative complications. Read More

Support Care Cancer 2019 Apr 13. Epub 2019 Apr 13.

Department of Nursing, The University of Melbourne, Melbourne, Victoria, Australia.

Purpose: Exercise is important in lung cancer, yet most people do not meet the physical activity guidelines. The aim of this study was to characterise the views and experiences of participants with inoperable lung cancer who completed a home-based rehabilitation program.

Methods: Ninety-two participants were recruited (45 intervention group [IG], 47 usual care). Read More

BMJ Support Palliat Care 2019 Apr 13. Epub 2019 Apr 13.

Center for Integrated Oncology (CIO), Bonn, Germany.

Objective: To describe psycho-oncological care structures and processes in German breast cancer centres from the perspective of the centre administration.

Methods: The findings are based on a postal survey of a representative random sample of surgical sites of certified breast cancer centres in Germany. Data were collected in 2013 and 2014. Read More

J Med Syst 2019 Apr 12;43(5):141. Epub 2019 Apr 12.

Struttura Complessa di Medicina Fisica e Riabilitativa, IRCCS - Istituto Ortopedico Rizzoli, Bologna, Italy.

Does a rehabilitation protocol based on balance exercises using Serious Game improve walk performance in patients undergoing knee resection and reconstruction for bone primary tumor?. 30 patients undergoing modular prosthetic replacement, following a primary bone tumor, were consecutively enrolled. During each hospitalization a physiotherapy treatment was activated, included 25 min training phase aimed postural and proprioceptive control. Read More

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

Metabolic diseases dramatically affect the life of men and women from infancy up to old age in different and manifold ways and are a major challenge for the healthcare system. The treating physicians are confronted with the different needs of women and men in the clinical routine. Gender-specific differences affect screening, diagnostic and treatment strategies as well as the development of complications and mortality rates. Read More

Stem Cells 2019 Apr 12. Epub 2019 Apr 12.

Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV.

Emerging evidence have shown that resting quiescent hematopoietic stem cells (HSCs) prefer to utilize anaerobic glycolysis rather than mitochondrial respiration for energy production. Compelling evidence has also revealed that altered metabolic energetics in HSC underlies the onset of certain blood diseases. However, the mechanisms responsible for energetic reprogramming remain elusive. Read More

J Community Health 2019 Apr 11. Epub 2019 Apr 11.

Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada.

Evidence of the dangers of indoor tanning and its popularity, including among youth, led the Government of Ontario to pass the Skin Cancer Prevention Act (Tanning Beds) (SCPA) in 2014. This legislation includes prohibiting the sale of indoor tanning services to individuals under 18, requiring warning signs be posted, and other safety regulations. We collected information from Ontario Public Health Units to conduct a process evaluation of the SCPA to: understand legislation implementation; assess available evidence about compliance, inspection, and enforcement; and, note barriers and facilitators related to inspection and enforcement. Read More

BMJ Open 2019 Apr 11;9(4):e025732. Epub 2019 Apr 11.

Department of Physiotherapy, Stellenbosch University, Cape Town, South Africa.

Introduction: Non-communicable diseases (NCDs) are the leading cause of death globally. Even though NCD disproportionally affects low-to-middle income countries, these countries including South Africa, often have limited capacity for the prevention and control of NCDs. The standard evidence-based care for the long-term management of NCDs includes rehabilitation. Read More

BMC Musculoskelet Disord 2019 Apr 11;20(1):166. Epub 2019 Apr 11.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Schwannomas are well-encapsulated, benign neoplasms, and enucleation is a standard operation procedure. The incidence of neurological complications after surgical treatment for schwannomas of the extremities varies, and there is no consensus concerning predictive factors for complications. The aim of this study was to elucidate predictive factors for complications after surgical treatment of schwannomas that develop in the major nerves of the extremities. Read More

BMC Cancer 2019 Apr 11;19(1):347. Epub 2019 Apr 11.

Department of Rehabilitation Medicine, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea.

Background: Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic stem cell transplantation (HSCT). Many previous studies show complications of the recipient after hematopoietic stem cell transplantation (HSCT). Read More

Ear Nose Throat J 2019 Apr 11:145561319839805. Epub 2019 Apr 11.

2 Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, USA.

Tyrosine kinase inhibitors (TKIs) aid in prolonging life in patients with advanced locoregional thyroid malignancy. Such patients may undergo total laryngectomy for local disease control and tracheoesophageal puncture (TEP) for speech rehabilitation. Enlargement of TEP fistulas is usually attributed to wound healing issues and leads to major complications. Read More

Cancers (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Palliative Care, Pain Therapy and Rehabilitation Department, Fondazione IRCCS-Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.

More than half of patients affected by cancer experience pain of moderate-to-severe intensity, often in multiple sites, and of different etiologies and underlying mechanisms. The heterogeneity of pain mechanisms is expressed with the fluctuating nature of cancer pain intensity and clinical characteristics. Traditional ways of classifying pain in the cancer population include distinguishing pain etiology, clinical characteristics related to pain and the patient, pathophysiology, and the use of already validated classification systems. Read More

Spine (Phila Pa 1976) 2019 Apr 8. Epub 2019 Apr 8.

Ferguson Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Study Design: An experimental laboratory study.

Objective: To investigate the pathogenesis of intervertebral disc degeneration (IDD) in a murine model of type 1 diabetes mellitus (DM), namely non-obese diabetic (NOD) mouse.

Summary Of Background Data: IDD is a leading contributor of low back pain, which represents one of the most disabling symptoms within the adult population. Read More

J Palliat Med 2019 Apr 11. Epub 2019 Apr 11.

7 Teaching and Research on Palliative Care Program, Hospital Sirio-Libanes, Sao Paulo, Brazil.

Background: Legal concerns have been implicated in the occurrence of variability in decisions of limitations of medical treatment (LOMT) before death.

Objective: We aimed to assess differences in perceptions between physicians and prosecutors toward LOMT.

Measurements: We sent a survey to intensivists, oncologists, and prosecutors from Brazil, from February 2018 to May 2018. Read More

Scand J Public Health 2019 Apr 11:1403494819838663. Epub 2019 Apr 11.

1 Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.

Aims: Frequent attendance in healthcare services is associated with ill-health and chronic illnesses. More information is needed about the phenomenon's connection with disability pensions (DPs).

Methods: The study group comprised 59,676 patients divided into occasional- (1yFAs) and persistent frequent attenders (pFAs) and non-frequent attenders (non-FAs). Read More

Ann Surg Oncol 2019 Apr 10. Epub 2019 Apr 10.

School of Nursing, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, China.

Objective: The aim of this study was to examine the effects of progressive upper limb exercises and muscle relaxation training (PULE-MRT) on upper limb function and health-related quality of life (HRQoL) following surgery in Chinese mainland women with breast cancer (BC).

Methods: Overall, 102 patients following surgery (i.e. Read More

Clin Pract Epidemiol Ment Health 2019 31;15:15-20. Epub 2019 Jan 31.

Department of Physical Education, State University of Montes Claros, Montes Claros, Brazil.

There is enough evidence that, nowadays, the sedentary lifestyle is one of the major health problems worldwide, linked to many chronic diseases, including mental comorbidities, systemic hypertension, metabolic dysregulation, and cancer. Although health societies recommend engagement to physical activities, there is an overwhelming number of people remaining sedentary, even knowing the health benefits of regular exercises. One of the main factors that justifies this scenario is the lack of motivation, which is a barrier to people intended to start new habits for health. Read More

Gut 2019 Apr 10. Epub 2019 Apr 10.

Section for Nutrition Research, Department of Medicine, Imperial College London, London, UK.

Objective: To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses.

Design: Twelve non-diabetic adults with overweight and obesity received 20 g/day of inulin-propionate ester (IPE), designed to selectively deliver propionate to the colon, a high-fermentable fibre control (inulin) and a low-fermentable fibre control (cellulose) in a randomised, double-blind, placebo-controlled, cross-over design. Outcome measurements of metabolic responses, inflammatory markers and gut bacterial composition were analysed at the end of each 42-day supplementation period. Read More

Oncol Res Treat 2019 Apr 10:1-7. Epub 2019 Apr 10.

Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.

Background: Posttherapeutic mucositis is a common secondary effect of oral cancer treatment. Mucositis affects the oral mucosa, which leads to specific physical impairments in oral function and a negative impact on quality of life.

Objective: To evaluate the impairments associated with oral mucositis and their impact on posttherapeutic quality of life. Read More

PLoS One 2019 10;14(4):e0214846. Epub 2019 Apr 10.

School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.

Evidence suggests physical activity (PA) is beneficial for people diagnosed with cancer. Clinical practice guidelines provide specific recommendations based on available research and are useful in informing evidence-based practice and guiding future research. Little is known on the extent and quality of guidelines on PA targeted to the cancer population. Read More

J Am Geriatr Soc 2019 Apr 10. Epub 2019 Apr 10.

Department of Palliative, Rehabilitation and Integrative Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.

Support Care Cancer 2019 Apr 10. Epub 2019 Apr 10.

Bristol Urological Institute, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.

Purpose: Patient-reported fatigue after robotic-assisted radical prostatectomy (RARP) has not been characterised to date. Fatigue after other prostate cancer (PCa) treatments is known to impact on patient-reported quality of life. The aim of this study was to characterise fatigue, physical activity levels and cardiovascular status post-RARP. Read More

Public Health Nurs 2019 Apr 9. Epub 2019 Apr 9.

University of Nebraska Medical Center, College of Nursing, Omaha, Nebraska.

Cancer-related fatigue (CRF) is an important public health issue that involves millions of community-dwelling cancer survivors. CRF is the most debilitating patient reported symptom related to cancer therapies and exacts a significant economic and social toll. It adversely impacts patients' work, social relationships, and overall quality of life. Read More