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Pain 2021 May 7. Epub 2021 May 7.

Department of Clinical Neuroscience, Karolinska Institutet, Nobels väg 9, 171 77 Stockholm, Sweden Department of Surgical Sciences, Uppsala University, Uppsala University Hospital 78, Uppsala, Sweden. Department of Anesthesiology, Chronic Pain and Fatigue Research Center, The University of Michigan, 24 Frank Lloyd Wright Dr. PO Box 385 Ann Arbor, MI 48106, USA Pain in Motion International Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Belgium Chronic pain rehabilitation, Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Belgium Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden Division of Neurological Pain Research and -therapy, Department of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany Departments of Anesthesiology & Perioperative Medicine and Biomedical & Molecular Sciences, Centre for Neuroscience Studies, and School of Policy Studies, Queen's University, Kingston, Canada Department of Neuroscience, Pharmacology & Psychiatry, Biomedical Research Center on Mental Health (CIBERSAM), University of Cádiz, Spain Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, United Kingdom RECOVER Injury Research Centre, The University of Queensland, Level 7, UQ Oral Health Centre, 288 Herston Road, Herston QLD 4006, Australia.

Int J Qual Stud Health Well-being 2021 Dec;16(1):1926052

Department of Design Sciences, Lund University, Lund, Sweden.

Purpose: Cancer research and connected innovation processes often lack a major component; patient participation. We revisit three studies (a-c) in order to explore how Momentary contentment theory may be used to improve patient participation and psychosocial health.

Method: We revisited data from the initial (a) classic grounded theory study on Momentary contentment, based on four years of observation and 14 interviews. Read More

Disabil Rehabil 2021 May 11:1-8. Epub 2021 May 11.

Division of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.

Purpose: Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.

Methods: Previous intervention (IG,  = 10; 58. Read More

Disabil Rehabil 2021 May 11:1-19. Epub 2021 May 11.

Discipline of Occupational, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Purpose: A scoping review of international literature was conducted to identify the various problems encountered by women with breast cancer associated with cognitive deficits, and the relationship to work roles and tasks.

Method: This scoping review was conducted using the structure recommended by Arksey & O'Malley in consideration of the PRISMA extension for Scoping Reviews checklist and reviewed for quality, inclusion criteria and key findings related to cognitive changes after breast and impact on work. Searches were conducted in five databases from January 2000 to December 2020. Read More

J Cancer Surviv 2021 May 11. Epub 2021 May 11.

Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Ave. South, Nashville, TN, 37212, USA.

Purpose: Persistent chemotherapy-related cognitive impairment (CRCI) is commonly reported following cancer treatment and negatively affects quality of life. While past research has focused on potential pathophysiological mechanisms underlying this relationship, the role of psychological factors, such as mood, stress, and anxiety, in the development of persistent CRCI has received less attention. As an additional analysis of data from a trial investigating the effects of transdermal nicotine patches on cognitive performance in patients with persistent CRCI, we examined whether change in mood was associated with changes in subjective and objective cognitive functioning. Read More

Int J Obes (Lond) 2021 May 10. Epub 2021 May 10.

Division of Community & Rehabilitation Psychiatry, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.

Background/objectives: Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. Read More

Lymphat Res Biol 2021 May 10. Epub 2021 May 10.

Department of Rehabilitation Medicine and College of Medicine, Chungnam National University, Daejeon, South Korea.

This study aimed at understanding the trend in extracellular fluid (ECF) change and estimating the efficacy of the early complex decongestive therapy (CDT) program in terms of prevalence of lower limb lymphedema, as well as at identifying the quality of life (QoL) associated with response to CDT after gynecological cancer therapy. Thirty-one patients undergoing gynecological cancer treatment were enrolled and randomly assigned to the CDT and control groups. In the CDT group, CDT was started within 2 weeks after surgery for 30 minutes a day, for 2 weeks (5 days per week). Read More

Brain 2021 May 10. Epub 2021 May 10.

Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity and biological significance. We report 25 families containing 34 individuals with neurological disease associated with biallelic HPDL variants. Phenotypes ranged from juvenile-onset pure hereditary spastic paraplegia to infantile-onset spasticity and global developmental delays, sometimes complicated by episodes of neurological and respiratory decompensation. Read More

Dev Neuropsychol 2021 Apr-Jun;46(3):249-264

Division of Neuropediatrics, Development and Rehabilitation, Children's University Hospital, Inselspital, University of Bern, Bern, Switzerland.

Childhood cancer and its treatment puts survivors at risk of low working memory capacity. Working memory represents a core cognitive function, which is crucial in daily life and academic tasks. The aim of this functional MRI (fMRI) study was to examine the working memory network of survivors of childhood cancer without central nervous system (CNS) involvement and its relation to cognitive performance. Read More

Int J Gynaecol Obstet 2021 May 9. Epub 2021 May 9.

Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Background: Ovarian carcinoma (OC) is one of the most widespread tumors in the world and is characterized by low survival rates.

Objective: To determine whether the levonorgestrel-releasing intrauterine system (LNG-IUS) can prevent OC.

Search Strategy: The literature until December 2020 were systematically reviewed according to the PRISMA Statement for Reporting Systematic Reviews (PROSPERO: CRD42019137957). Read More

Front Surg 2021 21;8:648345. Epub 2021 Apr 21.

Department of Medicine, Surgery, Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Sexual dysfunction (SD) is a frequent side effect associated with radical prostatectomy (RP) for prostate cancer (PCa). Some studies have showed the benefit associated with preoperative sexual rehabilitation (prehabilitation) and Enhanced Recovery After Surgery (ERAS) for RP, but no clear clinical recommendations are available yet. Our aim was to conduct a systematic review on sexual prehabilitation prior to RP for patients with a localized PCa and analyze the impact on postoperative sexual health compared with the standard post-operative care. Read More

Front Oncol 2021 23;11:630706. Epub 2021 Apr 23.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor worldwide. Analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases showed that the immune-related gene (IRG) hematopoietic cell signal transducer (HCST) could provide guidance for the diagnosis, prognosis, and treatment of ccRCC. The RNA-seq data of ccRCC tissues were extracted from two databases: TCGA (https://www. Read More

J Geriatr Oncol 2021 May 6. Epub 2021 May 6.

Division of Population Sciences, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States of America. Electronic address:

Objectives: To determine the association of physical activity and body image with psychological health outcomes and whether body image mediates the association of physical activity with psychological health among older female cancer survivors.

Materials And Methods: Data from the Women's Health Initiative (WHI) Life and Longevity after Cancer (LILAC) Study were used. Surveys assessed body image (appearance, attractiveness, scars), moderate-strenuous physical activity (min/week), and psychological health (depression, anxiety, distress). Read More

Ann Palliat Med 2021 Apr;10(4):4959-4964

Department of Lung Cancer, Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin, China.

The incidence and prevalence of obesity is drastically increasing worldwide. Clinical surgeons treating cancer patients often encounter obese patients. However, cases of surgical lung cancer patients with morbid obesity and poor pulmonary function undergoing lobectomy have not been reported. Read More

Ann Palliat Med 2021 Apr;10(4):4486-4492

Division II of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

Background: This study sought to explore the effects of personalized rehabilitation exercises in the postoperative rehabilitation of breast cancer patients.

Methods: A total of 93 breast cancer patients admitted to our hospital from January 2018 to December 2019 were taken as research subjects for this study. Based on order of admission, patients were assigned to a control group (46 cases) or an observation group (47 cases). Read More

Aust Occup Ther J 2021 May 9. Epub 2021 May 9.

School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, QLD, Australia.

Introduction: Up to one third of people with head and neck cancer undergoing radiation therapy experience mask anxiety. However, there is limited literature guiding the role of health professionals, including occupational therapists, in managing mask anxiety. This study aimed to explore the content of occupational therapy interactions with people who have identified mask anxiety. Read More

Dysphagia 2021 May 8. Epub 2021 May 8.

Radiation Oncology Department, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD, 4102, Australia.

This study explored associative relationships between radiotherapy dose volumes delivered to the dysphagia aspiration risk structures (DARS) and swallowing physiological disturbance at 3 months post treatment in a homogenous cohort of patients who received (chemo)radiotherapy ((C)RT) for oropharyngeal head and neck cancer (HNC). Participants(n = 53) were a subgroup of patients previously recruited as part of a prospective randomised trial, and had undergone physiological swallowing assessment using videofluroscopic swallowing study (VFSS) at 3 months post (C)RT. The extended oral cavity (EOC), supraglottic larynx (SGL), glottic larynx (GL), cricopharyngeal inlet (CI), and pharyngeal constrictor muscles (PCM) were contoured as per international consensus guidelines and dose volume histograms (DVHs) were generated for each structure. Read More

Exerc Immunol Rev 2021 ;27:142-166

Department of "Performance and Health (Sports Medicine)", Institute of Sport and Sport Science, Technical University Dortmund, Dortmund, Germany.

Many of the exercise-related health-promoting effects are attributed to beneficial immunomodulation. The restoration of immune homeostasis is context-dependent, meaning either to increase anti-inflammatory signaling to counteract disease progression of non-communicable (auto)inflammatory diseases or to enhance (local) activity of proinflammatory immune cells to slow down or inhibit cancer progression. Regulatory CD4+ T cells (Tregs) represent the main regulatory component of the adaptive immune system that fine-tunes inflammatory responses, keeps them in check and prevents long-lasting autoimmunity. Read More

Support Care Cancer 2021 May 8. Epub 2021 May 8.

School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia.

Purpose: To establish the feasibility of embedding a flexible, exercise-based rehabilitation program into a cancer treatment unit to allow cancer survivors early exercise support.

Method: A pre-post study was conducted using Bowen's Framework to describe key domains of feasibility: demand (referrals), acceptability (uptake, attendance, satisfaction), implementation (resources), practicality (adverse events, costs) and limited-efficacy (function, quality of life, self-efficacy). Participants were medically stable, adult cancer survivors receiving curative or palliative treatment for cancer at the health service. Read More

Sci Rep 2021 May 7;11(1):9743. Epub 2021 May 7.

Department of Biomedical Engineering, School of Material Science and Engineering, South China University of Technology, Guangzhou, 510006, China.

The effect of the gut microbiome on the central nervous system and its possible role in mental disorders have received increasing attention. However, knowledge about the relationship between the gut microbiome and brain structure and function is still very limited. Here, we used 16S rRNA sequencing with structural magnetic resonance imaging (sMRI) and resting-state functional (rs-fMRI) to investigate differences in fecal microbiota between 38 patients with schizophrenia (SZ) and 38 demographically matched normal controls (NCs) and explored whether such differences were associated with brain structure and function. Read More

J Aging Health 2021 May 7:8982643211017656. Epub 2021 May 7.

Department of Occupational Therapy, 6614University of Pittsburgh, Pittsburgh, PA, USA.

This study longitudinally examined how older adult cancer survivors perceive disability in activities of daily living over time compared to older adults who have not had cancer. This was a secondary analysis of the National Health and Aging Trends Study examining participants with a new cancer diagnosis and age-, gender-, and comorbidity-matched comparison participants without a history of cancer. Generalized linear mixed models examined time and group interaction and main effects in disability. Read More

Curr Pain Headache Rep 2021 May 7;25(7):44. Epub 2021 May 7.

Division of Pain Medicine, Department of Anesthesia, University of Pittsburgh Medical Center, Susquehanna, Williamsport, PA, USA.

Purpose Of Review: Pain is a prevalent symptom in the lives of patients with cancer. In light of the ongoing opioid epidemic and increasing awareness of the potential for opioid abuse and addiction, clinicians are progressively turning to interventional therapies. This article reviews the interventional techniques available to mitigate the debilitating effects that untreated or poorly treated pain have in this population. Read More

Eur J Pain 2021 May 7. Epub 2021 May 7.

Morlion Bart. Center for Algology & Pain Management, University Hospitals Leuven, Leuven, Belgium.

Background: There is considerable public interest in whether Europe is facing an opioid crisis comparable to the one in the U.S. and the contribution of opioid prescriptions for pain to a potential opioid crisis. Read More

Spine (Phila Pa 1976) 2021 May 6. Epub 2021 May 6.

Department of Interventional Pain Management, Providence Cedars-Sinai Tarzana Medical Center, Los Angeles, CA, USA Department of Interventional Pain Management, Providence St. Joseph Health Southern California, Mission Hills, CA, USA University of California San Diego School of Medicine, San Diego, CA, USA Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine, Salt Lake City, UT, USA. Spine Fracture Institute, Edmond, OK, USA Director of Neuro-Spine Surgery, Providence Cedars Sinai Tarzana Medical Center, Los Angeles, CA, USA Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Study Design: Systematic review and meta-analysis.

Objective: To compare the magnitude and duration of pain relief with vertebral augmentation to any other therapy for the treatment of cancer-related vertebral compression fractures through meta-analysis of randomized controlled trials.

Summary Of Background Data: Derived from search on PubMed, EMBASE, CINAHL, Scopus, Central, Scopus and Web of Science databases in May 2020. Read More

Neuron 2021 May;109(9):1426-1429

Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA. Electronic address:

Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge. Read More

Support Care Cancer 2021 May 6. Epub 2021 May 6.

School of Physical Education, Sport & Exercise Sciences, University of Otago, PO Box 56, Dunedin, New Zealand.

Purpose: Cardiovascular disease, often secondary to chemotherapy, is the leading cause of death in BC survivors. Increased aerobic capacity improves post-rehabilitation survival; however, many cancer rehabilitation programs are limited to lower intensity training. High-intensity interval training (HIIT) is associated with the largest improvements in aerobic capacity; therefore, this study aimed to determine whether HIIT would cause a greater increase in VOpeak than continuous moderate-intensity (MICT) exercise in previously trained BC survivors. Read More

Thorac Cancer 2021 May 6. Epub 2021 May 6.

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Recurrent laryngeal nerve paralysis (RLNP) is a common complication after esophagectomy which can cause severe pulmonary complications. However, bilateral RLNP has been rarely reported in esophagectomy patients. The objective of our study is to investigate the clinical significance of patients who had bilateral RLNP following esophagectomy. Read More

Mol Cell Biochem 2021 May 5. Epub 2021 May 5.

Department of Molecular Biology Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Although luminal breast cancer cells are typically highly cohesive epithelial cells and have low invasive ability, many eventually develop metastasis. Until now, the underlying mechanisms remain obscure. In this work, we showed that the level of hyaluronic acid synthase 2 (HAS2) was positively correlated with the malignant phenotype of breast cancer cells. Read More

Mol Neurobiol 2021 May 5. Epub 2021 May 5.

Faculty of Special Education and Rehabilitation, University of Belgrade, Visokog Stevana 2, 11000, Belgrade, Serbia.

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Read More

Int J Behav Med 2021 May 6. Epub 2021 May 6.

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Background: This pilot study explored the feasibility, acceptability, and usability of a web-based intervention for survivors of physical inactivity-related cancers through a two-arm, 12-week randomized controlled trial. Secondarily, this study tested the change in physical activity (PA) and sedentary time with intervention exposure.

Methods: Prior to randomization to the intervention (n = 45) or behavior "as usual" wait-listed control (n = 40) groups, participants completed baseline surveys and an accelerometer protocol. Read More