4,420 results match your criteria Cancer Science[Journal]


Structural and functional characterization of β -glycoprotein I domain 1 in anti-melanoma cell migration.

Cancer Sci 2019 Apr 23. Epub 2019 Apr 23.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan.

We previously found that circulating β -glycoprotein I inhibits human endothelial cell migration, proliferation, and angiogenesis via diverse mechanisms. In the present study, we investigated the antitumor activities of β -glycoprotein I using structure-function analysis and mapped the critical region within the β -glycoprotein I peptide sequence that mediates anticancer effects. We constructed recombinant cDNA and purified different β -glycoprotein I polypeptide domains using a baculovirus expression system. Read More

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http://dx.doi.org/10.1111/cas.14030DOI Listing

The pattern of cell-to-cell transfer of microRNA by gap junction and its effect on the proliferation of glioma cells.

Cancer Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.

microRNA is expected to be a novel therapeutic tool for tumors. Gap junctions facilitate the transfer of microRNA, which exerts biological effects on tumor cells. However, the length of microRNA that can pass through certain gap junctions that are composed of specific connexin remains unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14029
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http://dx.doi.org/10.1111/cas.14029DOI Listing
April 2019
1 Read

IDO1 promoter hypomethylation is associated with a poor prognosis in patients with esophageal cancer.

Cancer Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Indoleamine 2, 3-dioxygenase 1 (IDO1) is a primary enzyme that generates immunosuppressive metabolites. IDO1 plays a major role in tumor immunology and is a potential immune-based therapeutic target. We have reported that IDO1 protein expression was associated with an unfavorable clinical outcome in esophageal cancer. Read More

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http://dx.doi.org/10.1111/cas.14028DOI Listing

MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.

Cancer Sci 2019 Apr 21. Epub 2019 Apr 21.

Department of Molecular Genetics.

Xp11.2 translocation renal cell carcinoma (Xp11 tRCC) is a rare sporadic pediatric kidney cancer caused by constitutively active TFE3 fusion proteins. Tumors in patients with Xp11 tRCC tend to recur and undergo frequent metastasis, in part due to lack of methods available to detect early stage disease. Read More

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http://dx.doi.org/10.1111/cas.14026DOI Listing
April 2019
1 Read

Repressive role of stabilized HIF1α expression on TGFβ-induced extracellular matrix production in lung cancer cells.

Cancer Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Activation of transforming growth factor β (TGFβ) combined with persistent hypoxia are often affecting the tumor microenvironment. Disruption of cadherin/catenin complexes induced by these stimulations yields aberrant extracellular matrix (ECM) production, characteristics of an epithelial-mesenchymal transition (EMT). Hypoxia-inducible factors (HIFs), the hallmark of the response to hypoxia, play differential roles during development of diseases. Read More

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http://dx.doi.org/10.1111/cas.14027DOI Listing

Prognostic Relevance of Tertiary Lymphoid Organs Following Neoadjuvant Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma.

Cancer Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Gastroenterological Surgery II, Hokkaido University, Faculty of Medicine.

The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLOs) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. Read More

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http://dx.doi.org/10.1111/cas.14023DOI Listing

Pharmacokinetic study of the oral fluorouracil antitumor agent S-1 in patients with impaired renal function.

Cancer Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Kobe, Japan.

Although dose reduction of S-1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of this study was to investigate the pharmacokinetic parameters of 5-fluorouracil, 5-chloro-2,4 dihydroxypyridine, and oteracil potassium, and review the recommended dose modification of S-1 in patients with renal impairment. We classified patients receiving S-1 into four groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14025
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http://dx.doi.org/10.1111/cas.14025DOI Listing
April 2019
4 Reads

Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma.

Cancer Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Anti-PUF60 autoantibodies are reportedly detected in the sera of patients with dermatomyositis and Sjogren's syndrome; however, little is known regarding its existence in the sera of cancer patients. FIR, a splicing variant of the PUF60 gene, is a transcriptional repressor of c-myc. In colorectal cancer, there is an overexpression of the dominant negative form of FIR, in which exon 2 is lacking (FIRΔexon2). Read More

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http://dx.doi.org/10.1111/cas.14024DOI Listing
April 2019
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Epigenetic silencing of SOCS5 potentiates JAK-STAT signaling and progression of T-cell acute lymphoblastic leukemia.

Cancer Sci 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.

Activating mutations in cytokine receptors and transcriptional regulators govern aberrant signal transduction in T-cell lineage acute lymphoblastic leukemia (T-ALL). However, the roles played by suppressors of cytokine signaling remain incompletely understood. We examined the regulatory roles of SOCS5 in T-ALL cellular signaling networks and leukemia progression. Read More

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http://dx.doi.org/10.1111/cas.14021DOI Listing
April 2019
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The higher HLA class I expression in cancer cells at early stage lead to high sensitivity for cytotoxic T lymphocytes.

Cancer Sci 2019 Apr 11. Epub 2019 Apr 11.

Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center.

Human lymphocyte antigen (HLA) class I molecules play a central role in cytotoxic T lymphocytes (CTLs)-based antitumor immunity. However, the expression rate of HLA class I in cancer cells still remain discussing. We compared HLA class I expression levels between cancer cells and surrounding non-tumorous hepatocytes in 20 early-stage hepatocellular carcinoma (HCC) patients by immunohistochemistry using EMR 8-5. Read More

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http://dx.doi.org/10.1111/cas.14022DOI Listing
April 2019
1 Read

EGFR-targeted molecular imaging of colorectal tumors: detection and treatment evaluation of tumors in animal models.

Cancer Sci 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology and Oncology, University of Tokushima, Faculty of Medicine Graduate School of Medical Sciences, Tokushima, Tokushima, Japan.

To overcome the problem of overlooking colorectal tumors, a new and highly sensitive modality of colonoscopy is needed. Moreover, it is also important to establish a new modality to evaluate the viable tumor volume in primary lesions of colorectal cancer (CRC) during chemotherapy. Therefore, we performed molecular imaging of colorectal tumors targeting epidermal growth factor receptor (EGFR), which is highly expressed on tumor cells, for evaluating chemotherapeutic efficacy and for endoscopic detection of colorectal adenomas. Read More

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http://dx.doi.org/10.1111/cas.14020DOI Listing
April 2019
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Performance of Oncomine Fusion Transcript kit for formalin-fixed, paraffin-embedded lung cancer specimens.

Cancer Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Genome Biology, Kindai University, Faculty of Medicine, Osaka, Japan.

Gene fusions play an important role in the carcinogenesis of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and NTRK1, as lung tumor predictive biomarkers has increased the need for precision medicine. We used formalin-fixed, paraffin-embedded tissue samples of non-small cell lung cancer from 150 EGFR mutation-negative cases and 10 fusion status-known cases and compared the performance of the Oncomine Dx Fusion Transcript Test (ODxFT) with FISH Break Apart for the detection of ALK, RET, and ROS1 fusion genes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14016
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http://dx.doi.org/10.1111/cas.14016DOI Listing
April 2019
2 Reads

Clinical significance of PD-1 and PD-L1 expression in the tumor microenvironment of clear cell renal cell carcinoma.

Cancer Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Urology, Keio University School of Medicine, Tokyo.

Recently, immunotherapy based on blocking immune checkpoints with programmed death-1 (PD-1) or PD-ligand 1 (PD-L1) antibodies has been introduced for the treatment of advanced clear cell renal cell carcinoma (ccRCC), especially tumors resistant to vascular endothelial growth factor-tyrosine kinase inhibitors (VEGF-TKIs), but the significance of their expression in the tumor microenvironment is unclear. We investigated these immune checkpoint markers in tumor cells and tumor infiltrating immune cells (TIIC) in the tumor microenvironment of 100 untreated and 25 VEGF-TKI-treated primary ccRCC tissues. Upregulated expression of PD-1 and PD-L1 by TIIC, and PD-L1 by tumor cells was associated with the histological grade and unfavorable prognosis of RCC patients. Read More

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http://dx.doi.org/10.1111/cas.14019DOI Listing
April 2019
1 Read

Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.

Cancer Sci 2019 Apr 10. Epub 2019 Apr 10.

Duke Cancer Institute, Duke University Medical Center, Durham, NC, 27710, USA.

Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles in carcinogenesis remain only partially elucidated. Because the nuclear factor erythroid2-related factor2 (NRF2) signaling pathway is involved in human cancers, we hypothesize that genetic variants in NRF2 pathway genes are associated with PanC risk. Read More

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http://dx.doi.org/10.1111/cas.14017DOI Listing

c-Ski accelerates renal cancer progression by attenuating transforming growth factor β signaling.

Cancer Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Although TGF-β is known to be involved in the pathogenesis and progression of many cancers, its role in renal cancer has not been fully investigated. In the present study, we  examined the role of TGF-β in clear cell renal carcinoma (ccRCC) progression in vitro and in vivo. First, expression levels of TGF-β signaling pathway components were examined. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14018
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http://dx.doi.org/10.1111/cas.14018DOI Listing
April 2019
6 Reads

Long-term follow-up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma.

Cancer Sci 2019 Apr 8. Epub 2019 Apr 8.

Department of Medical Oncology/Hematology, Kobe University Graduate School of Medicine, Hyogo, Japan.

The immune checkpoint inhibitor, nivolumab, inhibits the programmed death 1 receptor and suppresses the immune resistance of cancer cells. This is a long-term follow-up of a single-arm, open-label, multicenter, phase II study of nivolumab in untreated Japanese patients with stage III/IV or recurrent melanoma. Additionally, a post-hoc subgroup analysis stratified by melanoma types was performed. Read More

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http://dx.doi.org/10.1111/cas.14015DOI Listing
April 2019
1 Read

MiRNA-331-3p inhibits epithelial-mesenchymal transition by targeting ErbB2 and VAV2 through the Rac1/PAK1/β-Catenin axis in NSCLC.

Cancer Sci 2019 Apr 7. Epub 2019 Apr 7.

Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.

MicroRNAs have been demonstrated to have critical roles in the regulation of NSCLC development, but the role of microRNA-331-3p in NSCLC is still unclear. In this study, the expression levels of miR-331-3p in NSCLC tumor tissues and adjacent normal tissues were examined by qRT-PCR, and the relationship between miR-331-3p expression and patient clinicopathological characteristics was analyzed. The effects of miR-331-3p on epithelial-mesenchymal transition (EMT), migration and metastasis of NSCLC cells were determined in vitro and vivo. Read More

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http://dx.doi.org/10.1111/cas.14014DOI Listing

Using recursive partitioning approach to select tumor-associated antigens in immunodiagnosis of gastric adenocarcinoma.

Cancer Sci 2019 Apr 5. Epub 2019 Apr 5.

Department of Epidemiology and Health statistics & Henan Key Laboratory for Tumor Epidemiology, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, China.

This study aimed to select anti-TAAs autoantibodies as biomarkers in immunodiagnosis of gastric adenocarcinoma (GAC) by recursive partitioning approach (RPA), and further construct and evaluate predictive model. A case-control study was designed, including 407 GAC patients as case group and 407 normal controls. In addition, 67 serial serum samples from 25 GAC patients were collected at different time points before and after gastrectomy treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14013
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http://dx.doi.org/10.1111/cas.14013DOI Listing
April 2019
7 Reads

Correction.

Authors:

Cancer Sci 2019 Apr;110(4):1503

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http://dx.doi.org/10.1111/cas.13927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447828PMC

Erratum.

Authors:

Cancer Sci 2019 Apr;110(4):1504

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http://dx.doi.org/10.1111/cas.13994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447839PMC

PGC1α/CEBPB/CPT1A axis promotes radiation resistance of nasopharyngeal carcinoma through activating fatty acid oxidation.

Cancer Sci 2019 Apr 4. Epub 2019 Apr 4.

Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.

The PPAR coactivator-1α (PGC1α) is an important transcriptional co-activator in control of fatty acid metabolism. Mitochondrial fatty acid oxidation (FAO) is the primary pathway for the degradation of fatty acids and it promotes NADPH and ATP production. Our previous study demonstrated that up-regulation of carnitine palmitoyl transferase 1 A (CPT1A), the key regulator of FAO, promotes radiation resistance of nasopharyngeal carcinoma (NPC). Read More

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http://dx.doi.org/10.1111/cas.14011DOI Listing
April 2019
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TRAF6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation.

Cancer Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology.

Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been found to be involved in carcinogenesis in multiple cancers. However, the precise role of TRAF6 in cancer has not been extensively investigated and remains largely unknown. In this study, we aimed to investigate the biological function of TRAF6 and its underlying molecular mechanisms in cancer. Read More

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http://dx.doi.org/10.1111/cas.14012DOI Listing
April 2019
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LncRNA TPT1-AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression.

Cancer Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Increasing numbers of studies have confirmed that long noncoding RNAs (lncRNAs) play a critical role in epithelial ovarian cancer (EOC) progression. However, the potential function of the lncRNA tumor protein translationally controlled 1 (TPT1) antisense RNA 1 (TPT1-AS1) in EOC is unclear. In this study, we aimed to uncover the biological roles and regulatory mechanisms of TPT1-AS1 in EOC progression and metastasis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14009
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http://dx.doi.org/10.1111/cas.14009DOI Listing
April 2019
4 Reads

Lysyl oxidase induces epithelial-mesenchymal transition and predicts intrahepatic metastasis of hepatocellular carcinoma.

Cancer Sci 2019 Mar 28. Epub 2019 Mar 28.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

Hepatocellular carcinoma (HCC) has high recurrence rates even after curative hepatectomy. Drug therapy for recurrence of HCC is still limited; therefore, identifying new therapeutic targets is urgently needed. We searched for genes that would predict HCC recurrence from intrahepatic metastasis in an exhaustive DNA microarray database by searching genes associated with high early recurrence rate and having higher expression in the tumor area compared to background liver. Read More

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http://dx.doi.org/10.1111/cas.14010DOI Listing
March 2019
1 Read

Serum deprivation-response protein regulates aldehyde dehydrogenase 1 through integrin-linked kinase signaling in endometrioid carcinoma cells.

Cancer Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan.

Endometrioid carcinoma (EC) is one of the most common malignancies of the female genital system. We reported previously that aldehyde dehydrogenase 1 (ALDH1), a predominant isoform of the ALDH family in mammals and a potential marker of normal and malignant stem cells, is related to the tumorigenic potential of EC. We compared the levels of various proteins in human EC cells with high and low ALDH1 expression using shotgun proteomics and found that serum deprivation-response protein (SDPR) was preferentially expressed in cells with high ALDH1 expression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14007
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http://dx.doi.org/10.1111/cas.14007DOI Listing
March 2019
3 Reads

Antitumor activity of Raddeanin A is mediated by Jun amino-terminal kinase activation and signal transducer and activator of transcription 3 inhibition in human osteosarcoma.

Cancer Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopaedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteosarcoma is the most common primary malignant bone tumor. Raddeanin A (RA) is an active oleanane-type triterpenoid saponin extracted from the traditional Chinese herb Anemone raddeana Regel that exerts antitumor activity against several cancer types. However, the effect of RA on osteosarcoma remains unclear. Read More

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http://dx.doi.org/10.1111/cas.14008DOI Listing
March 2019
2 Reads

Oncogenic Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer.

Cancer Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Y-box binding protein-1 (YBX1), a multifunctional oncoprotein containing an evolutionarily conserved cold shock domain, dysregulates a wide range of genes involved in cell proliferation and survival, drug resistance, and chromatin destabilization by cancer. Expression of a multidrug resistance-associated ATP binding cassette transporter gene, ABCB1, as well as growth factor receptor genes, EGFR and HER2/ErbB2, was initially discovered to be transcriptionally activated by YBX1 in cancer cells. Expression of other drug resistance-related genes, MVP/LRP, TOP2A, CD44, CD49f, BCL2, MYC, and androgen receptor (AR), is also transcriptionally activated by YBX1, consistently indicating that YBX1 is involved in tumor drug resistance. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14006
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http://dx.doi.org/10.1111/cas.14006DOI Listing
March 2019
4 Reads

New era of research on cancer-associated glycosphingolipids.

Cancer Sci 2019 Mar 21. Epub 2019 Mar 21.

Department of Biomedical Sciences.

Cancer-associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis of their implication in the malignant properties of cancer cells revealed that cancer-associated glycosphingolipids are not only tumor markers, but also function molecules regulating various signals introduced via membrane microdomains, lipid/rafts. In particular, a novel approach, enzyme-mediated activation of radical sources combined with mass spectrometry, has enabled us to clarify the mechanisms by which cancer-associated glycosphingolipids regulate cell signals based on the interaction with membrane molecules and formation of molecular complexes on the cell surface. Read More

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http://dx.doi.org/10.1111/cas.14005DOI Listing

Tolerability and efficacy of durvalumab in Japanese patients with advanced solid tumors.

Cancer Sci 2019 Mar 19. Epub 2019 Mar 19.

National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.

Blockade of programmed cell death ligand-1 with durvalumab has shown efficacy and safety in large, international studies of patients with advanced solid tumors. A phase 1, non-randomized, open-label multicenter study was initiated to evaluate durvalumab in a Japanese population. The first part of this study used a standard 3 + 3 dose-escalation design to determine the optimal dosing schedule of durvalumab. Read More

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http://dx.doi.org/10.1111/cas.14003DOI Listing
March 2019
1 Read

Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.

Cancer Sci 2019 Mar 19. Epub 2019 Mar 19.

School of Basic Medical Sciences, Wuhan University, Wuhan, China.

Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis. Hepatitis B virus (HBV) is one of the leading causes of HCC, but the precise mechanisms by which this infection promotes cancer development are not fully understood. Recently, miR-340-5p, a microRNA (miRNA) that has been identified as a cancer suppressor gene, was found to inhibit the migration and invasion of liver cancer cells. Read More

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http://dx.doi.org/10.1111/cas.14004DOI Listing
March 2019
1 Read

In commemoration of the 2018 Mataro Nagayo Prize: A road to early diagnosis and monitoring of asbestos-related mesothelioma.

Cancer Sci 2019 Mar 19. Epub 2019 Mar 19.

Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

Primarily caused by exposure to asbestos, mesothelioma is a typical occupational disease. The latency of mesothelioma is as long as 20-40 years, and the cancer initially progresses mainly along the surfaces of pleura or peritoneum without forming masses. As symptoms do not develop until late stages, it has been challenging to diagnose this disease in its early stages and to carry out complete surgical removal. Read More

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http://dx.doi.org/10.1111/cas.14001DOI Listing
March 2019
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AC016405.3, a novel long noncoding RNA, acts as a tumor suppressor through modulation of TET2 by microRNA-19a-5p sponging in glioblastoma.

Cancer Sci 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Long non-coding RNAs (lncRNAs) are crucial regulators in various malignancies including glioblastoma multiforme (GBM). In the present study, we screened out a new lncRNA, AC016405.3, through a previous genome-wide lncRNA microarray analysis in GBM. Read More

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http://dx.doi.org/10.1111/cas.14002DOI Listing

Diagnostic potential of TERT promoter and FGFR3 mutations in urinary cell-free DNA in upper tract urothelial carcinoma.

Cancer Sci 2019 Mar 18. Epub 2019 Mar 18.

Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.

Most upper tract urothelial carcinomas (UTUC) are muscle invasive at the time of diagnosis. Current standard methods for the diagnosis of UTUC are invasive. Urine cytology is the only non-invasive test for detecting UTUC, but its sensitivity is low. Read More

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http://dx.doi.org/10.1111/cas.14000DOI Listing

DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail.

Cancer Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Delta-like protein 3 (DLL3) is a ligand of Notch signaling, which mediates cell-fate decisions and is tumor-suppressive or oncogenic depending on the cellular context. Previous studies show that DLL3 is highly expressed in small cell lung cancer (SCLC) but not in normal lung tissue, suggesting that DLL3 might be associated with neuroendocrine tumorigenesis. However, its role in SCLC remains unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.13997
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http://dx.doi.org/10.1111/cas.13997DOI Listing
March 2019
16 Reads

The Sprouty/Spred family as tumor suppressors: Coming of age.

Cancer Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

The Ras/Raf/ERK pathway is one of the most frequently dysregulated signaling pathways in various cancers. In some such cancers, Ras and Raf are hotspots for mutations, which cause continuous activation of this pathway. However, in some other cancers, it is known that negative regulators of the Ras/Raf/ERK pathway are responsible for uncontrolled activation. Read More

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http://dx.doi.org/10.1111/cas.13999DOI Listing

Cancer-associated fibroblasts contribute to cisplatin resistance by modulating ANXA3 in lung cancer cells.

Cancer Sci 2019 Mar 13. Epub 2019 Mar 13.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

Cancer tissues consist of cancer cells, surrounding stromal cells and the extracellular matrix. Cancer-associated fibroblasts (CAF) are one of the key components of stromal cells. CAF have a great impact on the behavior of cancer cells, including proliferation, invasion, metastasis and chemoresistance in many ways. Read More

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http://dx.doi.org/10.1111/cas.13998DOI Listing
March 2019
3 Reads

Immune infiltration in renal cell carcinoma.

Cancer Sci 2019 Mar 12. Epub 2019 Mar 12.

Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, China.

Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor-infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further reveal the independent prognostic values of TIICs. Read More

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http://dx.doi.org/10.1111/cas.13996DOI Listing
March 2019
2 Reads

Glucose transporter 1 regulates the proliferation and cisplatin sensitivity of esophageal cancer.

Cancer Sci 2019 Mar 12. Epub 2019 Mar 12.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Glucose transporter 1 (GLUT1) expression is a prognostic marker for esophageal squamous cell carcinoma (ESCC). Recent work on GLUT1 and development of specific inhibitors supports the feasibility of GLUT1 inhibition as a treatment for various cancers. The anti-proliferative effects of GLUT1-specific small interfering RNA (siRNA) and a GLUT1 inhibitor were evaluated in ESCC cell lines. Read More

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http://doi.wiley.com/10.1111/cas.13995
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http://dx.doi.org/10.1111/cas.13995DOI Listing
March 2019
3 Reads

Targeting HOX/PBX dimer formation as a potential therapeutic option in esophageal squamous cell carcinoma.

Cancer Sci 2019 Mar 7. Epub 2019 Mar 7.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery I, Peking University Cancer Hospital and Institute, Beijing, China.

Homeobox genes are known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis, which are a family of transcriptional factors involved in determining cell identity during early development, and also dysregulated in many malignancies. Previously, HOXB7, HOXC6 and HOXC8 were found abnormally upregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with normal mucosa and seen as poor prognostic predictors for ESCC patients, and were shown to promote cell proliferation and anti-apoptosis in ESCC cells. These three HOX members have a high level of functional redundancy, making it difficult to target a single HOX gene. Read More

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http://dx.doi.org/10.1111/cas.13993DOI Listing

Hypoxia-inducible factor-1α and nuclear factor-κB play important roles in regulating programmed cell death ligand 1 expression by epidermal growth factor receptor mutants in non-small-cell lung cancer cells.

Cancer Sci 2019 Mar 7. Epub 2019 Mar 7.

Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Some driver gene mutations, including epidermal growth factor receptor (EGFR), have been reported to be involved in expression regulation of the immunosuppressive checkpoint protein programmed cell death ligand 1 (PD-L1), but the underlying mechanism remains obscure. We investigated the potential role and precise mechanism of EGFR mutants in PD-L1 expression regulation in non-small-cell lung cancer (NSCLC) cells. Examination of pivotal EGFR signaling effectors in 8 NSCLC cell lines indicated apparent associations between PD-L1 overexpression and phosphorylation of AKT and ERK, especially with increased protein levels of phospho-IκBα (p-IκBα) and hypoxia-inducible factor-1α (HIF-1α). Read More

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http://dx.doi.org/10.1111/cas.13989DOI Listing
March 2019
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Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer.

Cancer Sci 2019 Mar 7. Epub 2019 Mar 7.

Divisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia has been known as a central hallmark of cancer cells and their microenvironment. Indeed, hypoxia benefits cancer cells in their growth, survival, and metastasis. The historical discovery of hypoxia-inducible factor-1α (HIF1A) in the early 1990s had a great influence on the field as many phenomena in hypoxia could be explained by HIF1A. Read More

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http://dx.doi.org/10.1111/cas.13990DOI Listing
March 2019
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Heat shock factor 1 in cancer-associated fibroblasts is a potential prognostic factor and drives progression of oral squamous cell carcinoma.

Cancer Sci 2019 Mar 7. Epub 2019 Mar 7.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Heat shock factor 1 (HSF1) is highly expressed in various malignancies and is a potential modulator of tumor progression. Emerging evidence suggests that HSF1 activation in stromal cells is closely related to poor patient prognosis. However, the role of HSF1 in oral squamous cell carcinoma (OSCC) remains elusive. Read More

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http://dx.doi.org/10.1111/cas.13991DOI Listing

Nectin-2 in Ovarian Cancer: how is it expressed and what might be its functional role?

Cancer Sci 2019 Mar 7. Epub 2019 Mar 7.

Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, 97080, Würzburg, Germany.

Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Here we investigated Nectin-2 in ovarian cancer patients and in cell culture. Tumor as well as peritoneal biopsies of 60 ovarian cancer patients and 22 controls were dual stained for Nectin-2 and CD31 using immunohistochemistry. Read More

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http://dx.doi.org/10.1111/cas.13992DOI Listing
March 2019
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Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of rapamycin/hypoxia-inducible factor 1α axis.

Cancer Sci 2019 Mar 6. Epub 2019 Mar 6.

Department of Gastrointestinal Surgery, Guangdong Provincial People's Hospital, Guangzhou, China.

Inducing angiogenesis is a hallmark of cancers that sustains tumor growth and metastasis. Neovascularization is a surprisingly early event during the multistage progression of cancer. Cinobufagin, an important bufadienolide originating from Chan Su, has been clinically used to treat cancer in China since the Tang dynasty. Read More

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http://doi.wiley.com/10.1111/cas.13988
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http://dx.doi.org/10.1111/cas.13988DOI Listing
March 2019
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Silencing of DLEU2 suppresses pancreatic cancer cell proliferation and invasion by upregulating microRNA-455.

Cancer Sci 2019 Mar 5. Epub 2019 Mar 5.

Department of General Surgery, Linyi People's Hospital, Linyi, China.

Long noncoding RNA (lncRNA) DLEU2 has been shown to be dysregulated in several type of tumor. However, the potential biological roles and molecular mechanisms of DLEU2 in pancreatic cancer (PC) progression are poorly understood. In this study, we found that the DLEU2 level was substantially upregulated in PC tissues and PC cell lines, and significantly associated with poor clinical outcomes in PC patients. Read More

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http://dx.doi.org/10.1111/cas.13987DOI Listing
March 2019
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Squamous cell carcinoma antigen 1 is associated to poor prognosis in esophageal cancer through immune surveillance impairment and reduced chemosensitivity.

Cancer Sci 2019 Mar 2. Epub 2019 Mar 2.

Department of Medicine DIMED, University of Padua, Padua, Italy.

Squamous cell carcinoma antigen-1 (SCCA1) overexpression is associated with poor prognosis and chemoresistance in several tumor types, however, the underlying mechanisms remain elusive. Here, we report SCCA1 in relation to the immune and peritumoral adipose tissue microenvironment in early and advanced esophageal adenocarcinoma (EAC). In our series of patients with EAC, free SCCA1 serum levels were associated with significantly worse overall survival, and SCCA1-IgM serum levels showed a trend to a worse overall survival. Read More

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http://doi.wiley.com/10.1111/cas.13986
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http://dx.doi.org/10.1111/cas.13986DOI Listing
March 2019
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A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients.

Cancer Sci 2019 Feb 28. Epub 2019 Feb 28.

Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

A Disintegrin And Metalloprotease 23 (ADAM23), a member of the ADAM family, is involved in neuronal differentiation and cancer. ADAM23 is considered a possible tumor suppressor gene and is frequently downregulated in various types of malignancies. Its epigenetic silencing through promoter hypermethylation was observed in breast cancer (BC). Read More

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http://dx.doi.org/10.1111/cas.13985DOI Listing
February 2019
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Testis-specific protein, Y-linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression.

Cancer Sci 2019 Feb 28. Epub 2019 Feb 28.

Department of Medical Genetics, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

The testis-specific protein, Y-linked 1 (TSPY1), a newly recognized cancer/testis antigen, has been suggested to accelerate tumor progression. However, the mechanisms underlying TSPY1 cancer-related function remain limited. By mining the RNA sequencing data of lung and liver tumors from The Cancer Genome Atlas, we found frequent ectopic expression of TSPY1 in lung adenocarcinoma (LUAD) and liver hepatocellular carcinoma (LIHC), and the male-specific protein was associated with higher mortality rate and worse overall survival in patients with LUAD and LIHC. Read More

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http://dx.doi.org/10.1111/cas.13984DOI Listing
February 2019

Phase I study of tirabrutinib (ONO-4059/GS-4059) in patients with relapsed or refractory B-cell malignancies in Japan.

Cancer Sci 2019 Feb 27. Epub 2019 Feb 27.

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.

We evaluated the safety, efficacy, pharmacokinetics, pharmacodynamics and predictive biomarkers of tirabrutinib, a second-generation, enhanced-selectivity Bruton's tyrosine kinase inhibitor in Japanese patients with relapsed/refractory B-cell non-Hodgkin lymphoma (B-cell NHL) and chronic lymphocytic leukemia (CLL). This was an open-label, multicenter, phase I study. Seventeen patients (male N = 8) with a median age of 70 years were enrolled in 4 dose cohorts (160 mg once daily [N = 3], 320 mg once daily [N = 3], 480 mg once daily [N = 4] and 300 mg twice daily [N = 7]); 4 patients had continued tirabrutinib administration as of 4 January 2018. Read More

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http://dx.doi.org/10.1111/cas.13983DOI Listing
February 2019
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Integrative molecular profiling identifies a novel cluster of estrogen receptor-positive breast cancer in very young women.

Cancer Sci 2019 Feb 27. Epub 2019 Feb 27.

Center for Breast Cancer, Hospital, National Cancer Center, Goyang, Korea.

Very young breast cancer patients are more common in Asian countries than Western countries and are thought to have worse prognosis than older patients. The aim of the current study was to identify molecular characteristics of young patients with estrogen receptor (ER)-positive breast cancer by analyzing mutations and copy number variants (CNV), and by applying expression profiling. The whole exome and transcriptome of 47 Korean young breast cancer (KYBR) patients (age <35) were analyzed. Read More

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http://dx.doi.org/10.1111/cas.13982DOI Listing
February 2019
2 Reads