4,909 results match your criteria Cancer Science[Journal]


The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells.

Cancer Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family. Although EphA10 is involved in the malignancy of some types of cancer, its role as an oncogene has not been extensively studied. Here, we investigated the influence of EphA10 on the tumorigenic potential of pancreatic cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14568DOI Listing

The Biology and Therapeutic Potential of Mesenchymal Stem Cells derived Exosomes.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the potential to differentiate into several cell types. MSCs-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSCs are partially exerted by the secretion of soluble factors, in particular exosomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14563DOI Listing

The report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.

Cell line-derived xenograft (CDX) models created by implanting cancer cell lines into immunodeficient mice have been largely contributed to develop cancer drug therapies. However, cell lines often lose their original biological characteristics through many passages and cancer tissues in CDX models have many cancer cells and few cancer stromal cells, therefore, CDX models are currently considered not suitable for predicting the results of clinical studies. On the other hand, patient-derived xenograft (PDX) models are gaining importance, in which human cancer biological characteristics and microenvironments are recreated by implanting tumor tissue into immunodeficient mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14564DOI Listing

Propensity score analysis of overall survival between first- and second-generation EGFR-TKIs using the Real-World Data.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku Nagoya, Nagoya, Aichi, 464-8681, Japan.

We constructed a data set of EGFR-mutant NSCLC patients, and compared the overall survival of first-generation (1G), and second-generation (2G) EGFR-TKIs in clinical practice using propensity score. We reviewed the clinical data of consecutive EGFR-mutated NSCLC patients who received EGFR-TKI therapy between Jan 2008 and Aug 2017 at 11 institutions in Japan. The primary endpoint was OS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14560DOI Listing

Ezrin promotes hepatocellular carcinoma progression by modulating glycolytic reprogramming.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China.

Ezrin is one of the ezrin-radixin-moesin (ERM) proteins, which was involved in the formation of cell membrane processes, has been implicated in the promotion of cancers proliferation and metastasis. However, the possible role of Ezrin in hepatocellular carcinoma (HCC) metastasis and glycolysis reprogramming remained unclear. In this study, we found that Ezrin was upregulated in HCC tissues, and its overexpression was linked with HCC patients' aggressive tumor characteristics and poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14562DOI Listing

Synthetic Lethality strategies: Beyond BRCA1/2 mutations in pancreatic cancer.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China.

Cancer cells are often characterized by abnormalities in DNA damage response including defects in cell cycle checkpoints and/or DNA repair. Synthetic Lethality between DNA damage repair (DDR) pathways has provided a paradigm for cancer therapy by targeting DDR. The successful example is that cancer cells with BRCA1/2 mutations are sensitized to poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14565DOI Listing

A multicenter, open-label, phase II study of tirabrutinib (ONO/GS-4059) in patients with Waldenström's macroglobulinemia.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.

Tirabrutinib is a second-generation Bruton's tyrosine kinase inhibitor with greater selectivity than ibrutinib. Here we conducted a multicenter, phase II study of tirabrutinib in patients with treatment-naïve (Cohort A) or with relapsed/refractory (Cohort B) Waldenström's macroglobulinemia (WM). Patients were treated with tirabrutinib 480 mg once daily. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14561DOI Listing

LncRNA IGKJ2-MALLP2 suppresses LSCC proliferation, migration, invasion, and angiogenesis by sponging miR-1911-3p/p21.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang Province, China.

Because advanced laryngeal squamous cell carcinoma (LSCC) is diagnosed as a malignant tumor with a poor prognosis, the associated mechanisms still need to be further investigated. As key players in the development and progression of LSCC, lncRNAs have attracted increasing attention from many researchers. In this study, a novel lncRNA termed as IGKJ2-MALLP2 was identified and investigated for its effects on the development of LSCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14559DOI Listing

Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1 resulting in tumor proliferation in CRC.

Cancer Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

BRAF mutation accounts for up to 90 % of all BRAF mutations in human colorectal cancer (CRC), and constitutively activates the MEK-MAPK pathway. It is recognized that neutralizing monoclonal antibodies for epidermal growth factor receptor alone are not effective for CRC with BRAF mutation. Therefore, there are increasing interests in identification of the possible therapeutic targets in downstream of BRAF mutation in CRCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14558DOI Listing

A Nuclear lncRNA Linc00839 as a Myc target to promote breast cancer chemoresistance via PI3K/AKT Signaling Pathway.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Breast Diseases, Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, Jiangsu, China.

Chemoresistance has become a leading cause of mortality in breast cancer patients and is one of the major obstacles for improving the clinical outcome. Long noncoding RNAs play important roles in breast cancer tumorigenesis and chemoresistance. However, the involvement and regulation of lncRNAs in breast cancer chemoresistance are not completely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14555DOI Listing

Ribociclib, a CDK 4/6 inhibitor, plus endocrine therapy in Asian women with advanced breast cancer.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

National Hospital Organization, Osaka National Hospital, Osaka, Japan.

The ongoing, Phase Ib MONALEESASIA study is evaluating the efficacy and safety of ribociclib plus endocrine therapy in Asian patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer. Eligible patients from Japan, Hong Kong, and Singapore were enrolled in this 2-phase study consisting of a dose-escalation phase to determine the maximum-tolerated dose and the recommended Phase II dose of ribociclib plus letrozole, and a dose-expansion phase to evaluate safety and tolerability of ribociclib plus letrozole, fulvestrant, or tamoxifen. An exploratory biomarker analysis evaluating expression of target genes was also conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14554DOI Listing

Impact of DPYD, DPYS and UPB1 gene variations on severe drug-related toxicity in cancer patients.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Cancer treatment with a fluoropyrimidine (FP) is often accompanied by severe toxicity that may be dependent on the activity of catalytic enzymes encoded by the DPYD, DPYS and UPB1 genes. Genotype-guided dose individualization of FP therapy has been proposed in Western countries, but our knowledge of the relevant genetic variants in East Asian populations is presently limited. To investigate the association between these genetic variations and FP-related high toxicity in a Japanese population, we obtained blood samples from 301 patients who received this chemotherapy and sequenced the coding exons and flanking intronic regions of their DPYD, DPYS and UPB1 genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14553DOI Listing

Clinical utility of target capture-based panel sequencing in hematological malignancies: a multicenter feasibility study.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.

Although next-generation sequencing-based panel testing is well-practiced in the field of cancer medicine for the identification of target molecules in solid tumors, the clinical utility and clinical issues surrounding panel testing in hematological malignancies have yet to be fully evaluated. We conducted a multicenter prospective clinical-sequencing study to verify the feasibility of a panel test for hematological tumors, including acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, and diffuse large B-cell lymphoma. Out of 96 eligible patients, 79 patients (82%) showed potentially actionable findings, based on the clinical-sequencing assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14552DOI Listing

Clinical Characteristics of Hematological Patients Concomitant with COVID-19.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The rapid spread of COVID-19 represented the most serious issue to public health globally. Hematological patients as immunocompromised hosts are vulnerable to SARS-CoV-2 infection. There is rare information available regarding the clinical features of hematological patients concomitant with COVID-19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14544DOI Listing

Silent NK/T cell reactions to dasatinib during sustained deep molecular response before cessation are associated with longer treatment-free remission.

Cancer Sci 2020 Jun 7. Epub 2020 Jun 7.

Department of Hematology, Nippon Medical School, Tokyo, Japan.

This study presents the final report of the multicenter, prospective tyrosine kinase inhibitor discontinuation study, D-STOP, after a 3-year follow-up of 54 patients with chronic CML who discontinued dasatinib after a sustained deep molecular response (DMR) for ≥2 years with dasatinib treatment. Estimated treatment-free remission (TFR) rates at 12 and 36 months were 63.0% [95% confidence interval (CI): 48. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14518DOI Listing

Nuclear microenvironment in cancer: control through liquid-liquid phase separation.

Cancer Sci 2020 Jun 28. Epub 2020 Jun 28.

Division of Cancer Biology, The Cancer Institute of JFCR, Tokyo, Japan.

The eukaryotic nucleus is not a homogenous single-spaced but highly compartmentalized organelle, partitioned by various types of membrane-less structures, including nucleoli, PML bodies, paraspeckles, DNA damage foci, and RNA clouds. Over the past few decades, these nuclear structures have been implicated in biological reactions such as gene regulation and DNA damage response and repair, and thought to provide "microenvironments" facilitating these reactions in the nucleus. Notably, an altered morphology of these nuclear structures is found in many cancers, which may relate to so called "nuclear atypia" in histological examinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14551DOI Listing

Tetrahedral DNA nanostructures as drug delivery and bioimaging platforms in cancer therapy.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

Structural DNA nanotechnology enables DNA to be used as nanomaterials for novel nanostructure construction with unprecedented functionalities. Artificial DNA nanostructures can be designed and generated with precisely controlled features, resulting in its utility in bionanotechnological and biomedical applications. A tetrahedral DNA nanostructure (TDN), the most popular DNA nanostructure, with high stability and simple synthesis procedure, is a promising candidate as nanocarriers in drug delivery and bioimaging platforms, particularly in precision medicine as well as diagnosis for cancer therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14548DOI Listing

A novel cucurmosin-based immunotoxin targeting PD-L1 with high potency against human tumor in vitro and in vivo.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Pharmacology, School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China.

Immunotoxins are antibody-cytotoxin chimeric molecule with mighty cytotoxicity. Programmed cell death 1 ligand 1 (PD-L1), is a transmembrane protein expressed mainly in inflammatory tumor tissues and plays a pivotal role in immune escape and tumor progression. Although PD-L1 immune checkpoint therapy has been successful in some cases, many patients have not benefited enough in the end due to primary/secondary resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14549DOI Listing

Serum exsomal miR-766-3p expression is associated with poor prognosis of esophageal squamous cell carcinoma.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Epidemiology and Health Statistics, Fujian Medical University Fujian, Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.

To analyze the association between exosomal miR-766-3p expression levels in the serum and the prognosis of esophageal squamous cell carcinoma (ESCC). The serum global exosomal microRNA expression of ESCC patients was measured by microRNA microarray. Quantitative real-time polymerase chain reactions (qRT-PCR) were used to analyze the expression levels of candidate microRNAs in both serum and tissues from ESCC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14550DOI Listing

The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No 639, Zhizaoju Rd, Shanghai, 200011, China.

Receptor tyrosine kinases (RTKs) and Yes-associated protein (YAP) are critical driving factors in tumors. Currently, the regulation of RTKs in the Hippo-YAP pathway has been recognized as an important issue. However, the relationship between AXL, one of the RTKs, and YAP in head and neck squamous cell carcinoma (HNSCC) remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14546DOI Listing

ZNF251 promotes the progression of lung cancer by activating ERK signaling.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China, 200030.

Aberrant activation of ERK (extracellular signal-regulated kinase) signaling is a hallmark of lung cancer. Although constitutively activating mutations of EGFR (epidermal growth factor receptor) and KRAS contribute to the hyperactivation of ERK1/2, other mechanisms remain elusive. In this study, the zinc finger protein ZNF251 was found to be upregulated in clinical lung cancer samples, and it promoted the growth of lung cancer cells and the growth of primary lung KPC cells from mouse models (Ad-Cre; Kras ; P53 ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14547DOI Listing

A novel enhanced-GFP positive congenic inbred strain establishment and application of tumor-bearing nude mouse model.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Transgenic green fluorescent protein (GFP) gene mice are widely used. And for the unique advantages of immunodeficient animals in the field of oncology research, we aim to establish a nude mouse inbred strain, which stably expresses EGFP (enhanced-GFP) for the use of transplanted tumor microenvironment (TME) research. Female C57BL/6-Tg(CAG-EGFP) mice were backcrossed with male BALB/c nude mice for eleven generations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14545DOI Listing

Crossroads of telomere biology and anticancer drug discovery.

Authors:
Hiroyuki Seimiya

Cancer Sci 2020 Jun 24. Epub 2020 Jun 24.

Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.

The telomere is the specialized nucleoprotein complex at the end of the chromosome. Its highly conserved 5'-TTAGGG-3' repeats and shelterin protein complexes form a protective loop structure to maintain the integrity and stability of linear chromosomes. Although human somatic cells gradually shorten telomeres to undergo senescence or crisis, cancer cells activate telomerase, or the recombination-based mechanism to maintain telomeres and exhibit immortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14540DOI Listing

Phase II trial of pazopanib in patients with metastatic or unresectable chemoresistant sarcomas: a Japanese Musculoskeletal Oncology Group (JMOG) study.

Cancer Sci 2020 Jun 24. Epub 2020 Jun 24.

Department of Orthopaedic Surgery, Nagoya University, Nagoya, Japan.

Alveolar soft part sarcoma (ASPS), epithelioid sarcoma (ES), and clear cell sarcoma (CCS) are known to be chemoresistant tumors. The aim of this study is to investigate the effect of pazopanib on these chemoresistant tumors. This study is designed as a single arm, multicenter, investigator-initiated phase II trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14542DOI Listing

Tumor Immune Microenvironment and Immune Checkpoint Inhibitors in Esophageal Squamous Cell Carcinoma.

Cancer Sci 2020 Jun 24. Epub 2020 Jun 24.

Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.

Esophageal squamous cell carcinoma (ESCC) is the main prevalent histological type of esophageal cancer, predominantly constituting 90% of cases worldwide. Despite the development of multidisciplinary therapeutic approaches, its prognosis remains unfavorable. Recently, the development of monoclonal antibodies inhibiting programmed death 1 (PD-1) or programmed death-ligand 1 (PD-L1) has led to remarkable therapeutic responses among multiple malignancies including ESCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14541DOI Listing

HS2ST1-dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior.

Cancer Sci 2020 Jun 23. Epub 2020 Jun 23.

Department of Gynecology and Obstetrics, Münster University Hospital, Münster, Germany.

Heparan sulfate proteoglycans (HSPGs) act as signaling co-receptors by interaction of their sulfated glycosaminoglycan chains with numerous signaling molecules. In breast cancer, the function of heparan sulfate 2-O-sulfotransferase (HS2ST1), the enzyme mediating 2-O-sulfation of HS, is largely unknown. Hence, a comparative study on the functional consequences of HS2ST1 overexpression and siRNA knockdown was performed in the breast cancer cell lines MCF-7 and MDA-MB-231. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14539DOI Listing

Heterogeneity of cancer-associated fibroblasts: Opportunities for precision medicine.

Cancer Sci 2020 Jun 23. Epub 2020 Jun 23.

Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University Cancer Centre, Lund University, Medicon Village, 22381, Lund, Sweden.

Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor cell centric-view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer-associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14537DOI Listing

Anti-metastatic effects of thalidomide by inducing the functional maturation of peripheral NK cells.

Cancer Sci 2020 Jun 23. Epub 2020 Jun 23.

Institute of Natural Medicine, University of Toyama, Toyama, Japan.

Thalidomide and its analogues are known as immunomodulatory drugs (IMiDs) that possess direct anti-myeloma effects, in addition to other secondary effects, including anti-angiogenic, anti-inflammatory and immuno-modulatory effects. Although the involvement of NK cells in the anti-tumor effects of IMiDs has been reported, it is unclear whether IMiDs inhibit cancer cell metastasis by regulating the anti-tumor function of NK cells. In this study, we examined the protective effects of thalidomide against cancer metastasis by focusing on its immuno-modulatory effects through NK cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14538DOI Listing

The miR-1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer.

Cancer Sci 2020 Jun 18. Epub 2020 Jun 18.

Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.

Targeting the extracellular vesicle (EV) secretion can have potential clinical implications for cancer therapy; however, the precise regulatory mechanisms of EV secretion are not fully understood. Recently, we have shown a novel pathway of EV biogenesis in PCa cell lines, PC3 and PC3M. However, since the characteristics of EVs were divergent even among PCa cell lines, we hypothesized that other pathways or common regulatory pathways of EV biogenesis still exist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14535DOI Listing

HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors.

Cancer Sci 2020 Jun 18. Epub 2020 Jun 18.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Adult T cell leukemia-lymphoma (ATL) is a peripheral T cell malignancy caused by human T cell leukemia virus-type 1 (HTLV-1). Frequent structural variations that disrupt the 3' untranslated region of the programmed cell death-ligand 1 (PD-L1) gene have been found to result in overexpression of PD-L1 in ATL patients. The programmed cell death-1 (PD-1)-PD-L1 axis has thus attracted attention as a potential therapeutic target for ATL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14536DOI Listing

Soluble Vegfr3 gene therapy suppresses multi-organ metastasis in a mouse mammary cancer model.

Cancer Sci 2020 Jun 15. Epub 2020 Jun 15.

Department of Anatomy and Cell Biology, Osaka Medical College, Takatsuki, Japan.

Accumulating evidence on the association of VEGF-C with lymphangiogenesis and lymph node metastasis implicates lymphatic vessels as a potential target in anti-cancer therapy. To evaluate whether blocking VEGF-C and VEGFR-3 signaling can inhibit multi-organ metastases, a mouse metastatic mammary cancer model was subjected to gene therapy using a soluble VEGFR-3 expression vector (psVEGFR-3). We showed that psVEGFR-3 significantly diminished cell growth in vitro with or without added VEGF-C, and significantly reduced primary tumor growth and tumor metastases to wide-spectrum organs in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14531DOI Listing

Risk Factors of Local Recurrence after Surgery in Extra-Abdominal Desmoid-Type Fibromatosis: A Multicenter Study in Japan.

Cancer Sci 2020 Jun 15. Epub 2020 Jun 15.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.

This study was undertaken to clarify the risk factors, including the mutation status of CTNNB1, for the local recurrence after surgery of the rare disease, desmoid-type fibromatosis. It was designed as a multi-institutional joint research project with seven major centers in Japan participating. The committee members of seven major medical centers specializing in bone and soft tissue tumors formed this study group to develop clinical care guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14528DOI Listing

Investigating the health disparities in the association between lifestyle behaviors and the risk of head and neck cancer.

Cancer Sci 2020 Jun 15. Epub 2020 Jun 15.

National Institute of Cancer Research, National Health Research Institutes, 1F No 367, Sheng-Li Road, Tainan, 70456, Taiwan.

Many studies have reported a positive association between lower socioeconomic status (SES) and higher head and neck cancer (HNC) risk. Fewer studies have examined the impact of SES on the association between alcohol or cigarette use and HNC risk. The current case-control study (1,104 HNC cases and 1,363 controls) investigated the influence of education, a SES indicator, on the association between HNC and the use of alcohol, cigarettes, or betel quids in Taiwan, a country with universal health care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14530DOI Listing

Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells.

Cancer Sci 2020 Jun 15. Epub 2020 Jun 15.

Department of Immunology and Shandong Key Laboratory of Infection and Immunity, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

Programmed cell death-ligand 1 (PD-L1) expressed on cancer cells can cause immune escape of non-small-cell lung cancer (NSCLC). Elucidation of the regulatory mechanisms of the PD-L1 expression is a prerequisite for establishing new tumor immunotherapy strategies. Ubiquitin C-terminal hydrolase L1 (UCHL1) is a regulator of cellular signaling transduction that is aberrantly expressed in NSCLC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14529DOI Listing

5-FU resistance mechanisms in colorectal cancer: from classical pathways to promising processes.

Cancer Sci 2020 Jun 14. Epub 2020 Jun 14.

Laboratoire EA3842 CAPTuR «Contrôle de l'Activation cellulaire, Progression Tumorale et Résistances thérapeutiques», Faculté de médecine, 2 Rue du docteur Marcland, 87025, Limoges cedex, France.

Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the world, with nearly 1.8 million new cases diagnosed in 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14532DOI Listing

FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling and metastasis.

Cancer Sci 2020 Jun 14. Epub 2020 Jun 14.

Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Ubiquitin-dependent protein degradation has been implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis, many of which are involved in the initiation, progression, metastasis and drug resistance of cancers. E3 ubiquitin ligases are known to be the second most prevalent cancer-related functional gene family next to protein kinases. Of these, FBXO22, an F-box receptor subunit of SCF E3 ligase, has recently been proposed to play a critical role in multiple aspects related to cancer development and therapy response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14534DOI Listing

CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.

Cancer Sci 2020 Jun 14. Epub 2020 Jun 14.

Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan.

CENP-50/U is a component of the CENP-O complex (CENP-O/P/Q/R/U) and localizes to the centromere throughout the cell cycle. Aberrant expression of CENP-50/U has been reported in many types of cancers. However, as Cenp-50/U-deficient mice die during early embryogenesis, its functions remain poorly understood in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14533DOI Listing

Cancer-associated adipocytes promote pancreatic cancer progression through SAA1 expression.

Cancer Sci 2020 Jun 14. Epub 2020 Jun 14.

Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.

Although pancreatic cancer often invades into peripancreatic adipose tissue, little is known about the cancer-adipocyte interaction. We first investigated the ability of adipocytes to de-differentiate to cancer-associated adipocytes (CAAs) by co-culturing with pancreatic cancer cells. We then examined the effects of CAA-conditioned media (CAA-CM) on the malignant characteristics of cancer cells, the mechanism underlying those effects, and their clinical relevance in pancreatic cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14527DOI Listing

Retraction.

Authors:

Cancer Sci 2020 06;111(6):2196

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293101PMC

FGFR4 increases EGFR signaling by inducing AREG expression and attenuates response to EGFR inhibitors in colon cancer.

Cancer Sci 2020 Jun 13. Epub 2020 Jun 13.

Division of Hematology-Oncology, Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, South Korea.

Fibroblast growth factor receptor 4 (FGFR4) is known to induce cancer cell proliferation, invasion, and anti-apoptosis via activation of RAS/RAF/ERK and PI3K/AKT pathways, which are also known as major molecular bases of colon cancer carcinogenesis related with EGFR signaling. However, the interaction of FGFR4 and EGFR signaling in regard to colon cancer progression is unclear. Here, we investigated a potential crosstalk between FGFR4 and EGFR, and the effect of anti-EGFR therapy in colon cancer treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14526DOI Listing

Systematic profiling of alternative splicing signature reveals prognostic predictor for prostate cancer.

Cancer Sci 2020 Jun 12. Epub 2020 Jun 12.

Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Alternative splicing (AS) provides the primary mechanism for producing protein diversity. There is growing evidence that AS is involved in the development and progression of cancers. The rapid accumulation of high-throughput sequencing technologies and clinical data sets offers an opportunity to systematically profile the relationship between mRNA variants and clinical outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14525DOI Listing

Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma.

Cancer Sci 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Recent studies have revealed that metabolic reprogramming is closely associated with epithelial-mesenchymal transition (EMT) during cancer progression. Aldolase A (ALDOA) is a key glycolytic enzyme that is highly expressed in several types of cancer. In this study, we found that ALDOA is highly expressed in uterine cervical adenocarcinoma and that high ALDOA expression promotes EMT to increase malignant potentials, such as metastasis and invasiveness, in cervical adenocarcinoma cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14524DOI Listing

Tumor-associated macrophage-derived inflammatory cytokine enhances malignant potential of malignant pleural mesothelioma.

Cancer Sci 2020 Jun 12. Epub 2020 Jun 12.

Department of Respiratory Medicine and Hematology, Hyogo College of Medicine, Nishinomiya, Japan.

Malignant pleural mesothelioma (MPM) is an asbestos-related aggressive malignant neoplasm. Due to the difficulty of achieving curative surgical resection in most patients with MPM, a combination chemotherapy of cisplatin and pemetrexed has been the only approved regimen proven to improve the prognosis of MPM. However, the median overall survival time is at most 12 mo even with this regimen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14523DOI Listing

Tumor microenvironment in gastric cancers.

Cancer Sci 2020 Jun 10. Epub 2020 Jun 10.

Department of Gastroenterology, Graduate school of Medicine, the University of Tokyo, Tokyo, 1138655, Japan.

The tumor microenvironment favors the growth and expansion of cancer cells. Many cell types are involved in the tumor microenvironment, such as inflammatory cells, fibroblasts, nerves, and vascular endothelial cells. These stromal cells contribute to tumor growth by releasing various molecules to either directly activate the growth signaling in cancer cells or remodel surrounding circumstances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14521DOI Listing

Peptide-2 from mouse myostatin precursor protein alleviates muscle wasting in cancer-associated cachexia.

Cancer Sci 2020 Jun 10. Epub 2020 Jun 10.

Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Cancer cachexia, characterized by continuous muscle wasting, is a key determinant of cancer-related death; however, there are few medical treatments to combat it. Myostatin (MSTN)/growth differentiation factor 8 (GDF-8), which is a member of the transforming growth factor-β family, is secreted in an inactivated form noncovalently bound to the prodomain, negatively regulating the skeletal muscle mass. Therefore, inhibition of MSTN signaling is expected to serve as a therapeutic target for intractable muscle wasting diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14520DOI Listing

The knockdown of GPSM2 promotes the metastasis of non-small cell lung cancer by inducing the expression of Snail.

Cancer Sci 2020 Jun 10. Epub 2020 Jun 10.

Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang, 110001, China.

Non-small cell lung cancer (NSCLC) is the leading global cause of cancer-related death. Due to the lack of reliable diagnostic or prognostic biomarkers, the prognosis of NSCLC remains poor. Consequently, there is an urgent need to explore the mechanisms underlying this condition in order to identify effective biomarkers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14519DOI Listing

MiR-145 in cancer therapy resistance and sensitivity: A comprehensive review.

Cancer Sci 2020 Jun 7. Epub 2020 Jun 7.

Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

MircoRNA (miRNA) are a group of small, non-coding, regulatory RNA with an average length of approximately 22 nucleotides, which mostly modulate gene expression post-transcriptionally through complementary binding to the 3'-untranslated region (3'-UTR) of multiple target genes. Emerging evidence has shown that miRNA are frequently dysregulated in a variety of human malignancies. Among them, microRNA-145 (miR-145) has been increasingly identified as a critical suppressor of carcinogenesis and therapeutic resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14517DOI Listing

RNA sequencing of plasma exosomes revealed novel functional long noncoding RNAs in hepatocellular carcinoma.

Cancer Sci 2020 Jun 7. Epub 2020 Jun 7.

School of Public Health, Guangxi Medical University, Nanning, China.

Exosomal long noncoding RNA (lncRNA) has been found to be associated with the development of cancers. However, the expression characteristics and the biological roles of exosomal lncRNAs in hepatocellular carcinoma (HCC) remain unknown. Here, by RNA sequencing, we found 9440 mRNAs and 8572 lncRNAs were differentially expressed (DE-) in plasma exosomes between HCC patients and healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14516DOI Listing

The genetic landscape of external auditory canal squamous cell carcinoma.

Cancer Sci 2020 Jun 5. Epub 2020 Jun 5.

Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, 860-8556, Japan.

External auditory canal squamous cell carcinoma (EACSCC) is an extremely rare and aggressive malignancy. Due to its rarity, the molecular and genetic characteristics of EACSCC have not yet been elucidated. To reveal the genetic alterations of EACSCC, we performed whole exome sequencing (WES) on 11 primary tumors, one relapsed tumor and 10 noncancerous tissues from 10 patients with EACSCC, including one with a rare case of synchronous bilateral EACSCC of both ears. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14515DOI Listing