1,521 results match your criteria Cancer Research And Treatment[Journal]


Early Assessment of Response to Neoadjuvant Chemotherapy with 18F-FDG-PET/CT in Patients with Advanced-Stage Ovarian Cancer.

Cancer Res Treat 2020 Apr 28. Epub 2020 Apr 28.

Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The aim of this study was to evaluate the ability of sequential 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) after one cycle of neoadjuvant chemotherapy (NAC) to predict chemotherapy response before interval debulking surgery (IDS) in advanced-stage ovarian cancer patients.

Material And Methods: Forty consecutive patients underwent 18F-FDG-PET/CT at baseline and after one cycle of NAC. Metabolic responses were assessed by quantitative decrease in the maximum standardized uptake value (SUVmax) with PET/CT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.506DOI Listing

Evaluation of the American Joint Committee on Cancer (AJCC) 8th Edition Staging System for Hepatocellular Carcinoma in 1,008 Patients with Curative Resection.

Cancer Res Treat 2020 Apr 28. Epub 2020 Apr 28.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Recently, the 8th edition staging system of the American Joint Committee on Cancer (AJCC) for hepatocellular carcinoma (HCC) was released, including a change in T category. We aimed to validate the new AJCC system.

Materials And Methods: The predictive value of the new AJCC was validated in comparison to the previous edition, in a total 1,008 patients who underwent curative resection for HCC as initial treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.208DOI Listing

Increasing Incidence of B-Cell Non-Hodgkin Lymphoma and Occurrence of Second Primary Malignancies in South Korea: 10-Year Follow-up Using the Korean National Health Information Database.

Cancer Res Treat 2020 May 4. Epub 2020 May 4.

Department of Preventative Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The epidemiology of B-cell non-Hodgkin lymphoma (BNHL) in Asia is not well described, and rates of second primary malignancies (SPM) in these patients are not known. We aimed to describe temporal changes in BNHL epidemiology and SPM incidence in Korea.

Materials And Methods: A retrospective cohort study used claims data from the National Health Insurance Service that provides universal healthcare coverage in Korea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.089DOI Listing

A Multi-cohort Study of the Prognostic Significance of Microsatellite Instability or Mismatch Repair Status after Recurrence of Resectable Gastric Cancer.

Cancer Res Treat 2020 May 4. Epub 2020 May 4.

Department of Surgery, Yonsei University Health System, Seoul, Korea.

Purpose: High microsatellite instability (MSI) is related to good prognosis in gastric cancer. We aimed to identify the prognostic factors of patients with recurrent gastric cancer and investigate the role of MSI as a prognostic and predictive biomarker of survival after tumor recurrence.

Materials And Methods: This retrospective cohort study enrolled patients treated for stage II/III gastric cancer who developed tumor recurrence and in whom the MSI status or mismatch repair (MMR) status of the tumor was known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.173DOI Listing

Evaluation of Circulating Tumor DNA in Patients with Ovarian Cancer Harboring Somatic PIK3CA or KRAS Mutations.

Cancer Res Treat 2020 May 6. Epub 2020 May 6.

Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Japan.

Purpose: Circulating tumor DNA (ctDNA) is an attractive source for liquid biopsy to understand molecular phenotypes of a tumor non-invasively, which is also expected to be both a diagnostic and prognostic marker. PIK3CA and KRAS are among the most frequently mutated genes in epithelial ovarian cancer (EOC). In addition, their hotspot mutations have already been identified and are ready for a highly sensitive analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.688DOI Listing

Elevated Expression of RIOK1 Is Correlated with Breast Cancer Hormone Receptor Status and Promotes Cancer Progression.

Cancer Res Treat 2020 May 8. Epub 2020 May 8.

Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Purpose: RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers-such as colorectal and gastric cancers. However, the expression of RIOK1 in breast cancer (BC) and the relationship between RIOK1 expression and the development of BC are not well characterized. In this study, we assessed the expression of RIOK1 in BC and evaluated the mechanisms underlying its biological function in this disease context. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.187DOI Listing

Real World Experience of Nivolumab in Non-Small Cell Lung Cancer in Korea.

Cancer Res Treat 2020 May 15. Epub 2020 May 15.

Division of Hematology-Oncology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

Purpose: The introduction of immune checkpoint inhibitors represents a major advance in the treatment of lung cancer, allowing sustained recovery in a significant proportion of patients. Nivolumab is a monoclonal anti-PD-1 antibody licensed for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy. In this study, we describe the demographic and clinical outcomes of patients with advanced NSCLC treated with nivolumab in the Korean expanded access program (EAP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.245DOI Listing

FGFR4 Gly388Arg Polymorphism Affects the Progression of Gastric Cancer by Activating STAT3 Pathway to Induce Epithelial to Mesenchymal Transition.

Cancer Res Treat 2020 May 25. Epub 2020 May 25.

Department of Gastrointestinal Surgery and Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Purpose: Fibroblast growth factor receptor 4 (FGFR4) plays a critical role in cancer progression involving in tumor proliferation, invasion, and metastasis. This study clarified the role of FGFR4-Arg388 variant in gastric cancer (GC), and more importantly highlighted the possibility of this single nucleotide polymorphism (SNP) as potential therapeutic targets.

Materials And Methods: FGFR4 polymorphism was characterized in advanced GC patients to perform statistical analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.138DOI Listing

β1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/β-catenin Signaling Pathway.

Cancer Res Treat 2020 May 27. Epub 2020 May 27.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

Purpose: Breast cancer stem cells (BCSCs) contribute to the initiation, development, and recurrence of breast carcinomas. β1,4-Galactosyltransferase V (B4GalT5), which catalyzes the addition of galactose to GlcNAcβ1-4Man of N-glycans, is involved in embryogenesis. However, its role in the modulation of BCSCs remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.093DOI Listing

Genetic Alterations in Preinvasive Lung Synchronous Lesions.

Cancer Res Treat 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology and Translational Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: Despite advances in treatment, lung cancer remains the leading cause of cancer mortality. This study aimed to characterise genome-wide tumorigenesis events and to understand the hypothesis of the multistep carcinogenesis of lung adenocarcinoma (LUAD).

Materials And Methods: We conducted multiregion whole-exome sequencing of LUAD with synchronous atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ, or minimally invasive adenocarcinoma of 19 samples from three patients to characterize genome-wide tumorigenesis events and validate the hypothesis of the multistep carcinogenesis of LUAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.307DOI Listing

Nomogram for Predicting Central Lymph Node Metastasis in Papillary Thyroid Cancer: A Retrospective Cohort Study of Two Clinical Centers.

Cancer Res Treat 2020 Jun 9. Epub 2020 Jun 9.

Department of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.

Purpose: Central lymph node metastasis (CNM) are highly prevalent but hard to detect preoperatively in papillary thyroid carcinoma (PTC) patients, while the significance of prophylactic compartment central lymph node dissection (CLND) remains controversial as a treatment option. We aim to establish a nomogram assessing risks of CNM in PTC patients, and explore whether prophylactic CLND should be recommended.

Materials And Methods: One thousand four hundred thirty-eight patients from two clinical centers that underwent thyroidectomy with CLND for PTC within the period 2016-2019 were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.254DOI Listing

Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer.

Cancer Res Treat 2020 Jun 11. Epub 2020 Jun 11.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Microsatellite instability (MSI) status may affect the efficacy of adjuvant chemotherapy in gastric cancer. In this study, the clinical characteristics of MSI-high (MSI-H) gastric cancer and the predictive value of MSI-H for adjuvant chemotherapy in large cohorts of gastric cancer patients were evaluated.

Material And Methods: This study consisted of two cohorts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.313DOI Listing

Protective Effects of N-acetylcysteine against Radiation-Induced Oral Mucositis In Vitro and In Vivo.

Cancer Res Treat 2020 Jun 18. Epub 2020 Jun 18.

Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea.

Purpose: Radiation-induced oral mucositis limits delivery of high-dose radiation to targeted cancers. Therefore, it is necessary to develop a treatment strategy to alleviate radiation-induced oral mucositis during radiation therapy. We previously reported that inhibiting reactive oxygen species (ROS) generation suppresses autophagy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.012DOI Listing

EGFR C797S as a Resistance Mechanism of Lazertinib in Non-small Cell Lung Cancer with EGFR T790M Mutation.

Cancer Res Treat 2020 Jun 22. Epub 2020 Jun 22.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation eventually acquires resistant to either first or second-generation EGFR tyrosine kinase inhibitor (TKI). As the following option, targeting EGFR T790M with third-generation EGFR TKI is now established as a standard treatment option. In this study, we are reporting the first case of resistance mechanism to the novel third-generation EGFR TKI, lazertinib, which showed promising clinical efficacy in phase 1-2 study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.278DOI Listing

The Fear of Cancer from the Standpoint of Oneself, the Opposite Sex and the Fear of Side Effects of Cancer Treatment.

Cancer Res Treat 2020 Jun 24. Epub 2020 Jun 24.

National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Purpose: It is important to understand the differences between men and women when it comes to attitudes and risk perception toward disease. This study aimed to explore the fear of cancer from the standpoint of themselves and the opposite sex by cancer type.

Materials And Methods: A cross-sectional survey with a representative sample was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.285DOI Listing

Genome-Wide Association Study for the Identification of Novel Genetic Variants Associated with the Risk of Neuroblastoma in Korean Children.

Cancer Res Treat 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Neuroblastoma (NB) is the most common extracranial solid tumor found in children. To identify significant genetic factors for the risk of NB, several genetic studies was conducted mainly for Caucasians and Europeans. However, considering racial differences, there is a possibility that genetic predispositions that contribute to the development of NB are different, and GWAS study has not yet been conducted on Korean NB patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.140DOI Listing

Challenge for Diagnostic Assessment of Deep Learning Algorithm for Metastases Classification in Sentinel Lymph Nodes on Frozen Tissue Section Digital Slides in Women with Breast Cancer.

Cancer Res Treat 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Purpose: Assessing the status of metastasis in sentinel lymph nodes (SLNs) by pathologists is an essential task for the accurate staging of breast cancer. However, histopathological evaluation of sentinel lymph nodes by a pathologist is not easy and is a tedious and time-consuming task. The purpose of this study is to review a challenge competition (HeLP 2018) to develop automated solutions for the classification of metastases in hematoxylin and eosin-stained frozen tissue sections of SLNs in breast cancer patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.337DOI Listing

Choosing Wisely: The Korean Perspective and Launch of the 'Right Decision in Cancer Care' Initiative.

Cancer Res Treat 2020 Jun 2. Epub 2020 Jun 2.

Division of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.

Government healthcare expenditure is rising in Korea, and the costs incurred by patients in Korea exceed those incurred by patients in other Organization for Economic Co-operation and Development countries. Despite the increasing health expenditure, patient demand for services is increasing as well, so it is now becoming recognized that cancer care needs to be balanced. The most important measure in cancer care optimization is to provide high-quality care while keeping costs sustainable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.221DOI Listing

A Phase II Study of Avelumab Monotherapy in Patients with Mismatch Repair-Deficient/Microsatellite Instability-High or POLE-Mutated Metastatic or Unresectable Colorectal Cancer.

Cancer Res Treat 2020 Apr 24. Epub 2020 Apr 24.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: We evaluated the efficacy and safety of avelumab, an anti-PD-L1 antibody, in patients with metastatic or unresectable colorectal cancer (mCRC) with mismatch repair deficiency (dMMR)/microsatellite instability-high (MSI-H) or POLE mutations.

Materials And Methods: In this prospective, open-label, multicenter phase II study, 33 patients with mCRC harboring dMMR/MSI-H or POLE mutations after failure of ≥1st-line chemotherapy received avelumab 10 mg/kg every 2 weeks. dMMR/MSI-H was confirmed with immunohistochemical staining (IHC) by loss of expression of MMR proteins or polymerase chain reaction (PCR) for microsatellite sequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.218DOI Listing

Real-World Data of Pyrotinib-Based Therapy in Metastatic HER2-Positive Breast Cancer: Promising Efficacy in Lapatinib-Treated Patients and in Brain Metastasis.

Cancer Res Treat 2020 Apr 24. Epub 2020 Apr 24.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: Pyrotinib is a newly-developed irreversible pan-ErbB receptor tyrosine kinase inhibitor. This study reported the first real-world data of pyrotinib-based therapy in metastatic human epidermal growth factor receptor 2 (HER2)-positive (BC), focusing on efficacy in lapatinib-treated patients and in brain metastasis. Methods One hundred thirteen patients with metastatic HER2-positive BC treated with pyrotinib-based therapy in Fudan University Shanghai Cancer Center under non-clinical trial settings from September 1, 2018 to March 1, 2019 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.633DOI Listing
April 2020
2.975 Impact Factor

RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer.

Cancer Res Treat 2020 Apr 22. Epub 2020 Apr 22.

State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.

Purpose: Triple-negative breast cancer (TNBC) is highly malignant and has poor prognosis and a high mortality rate. The lack of effective therapy has spurred our investigation of new targets for treating this malignant cancer. Here, we identified RON (macrophage-stimulating 1 receptor) and MET (MET proto-oncogene, receptor tyrosine kinase) as a prognostic biomarker and therapeutic targets for potential TNBC treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.726DOI Listing

Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas.

Cancer Res Treat 2020 Apr 23. Epub 2020 Apr 23.

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The aim of this study is to evaluate the survival rate and prognostic factors of anaplastic gliomas according to the 2016 World Health Organization classification, including extent of resection (EOR) as measured by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) and the T2-weighted MRI.

Materials And Methods: The records of 113 patients with anaplastic glioma who were newly diagnosed at our institute between 2000 and 2013 were retrospectively reviewed. There were 62 cases (54. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.057DOI Listing

Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer.

Cancer Res Treat 2020 Apr 17. Epub 2020 Apr 17.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Currently, the DNA damage response (DDR) pathway represents a key target for new cancer drug development. Advanced biliary tract cancer (BTC) has a poor prognosis because of the lack of efficacious treatment options. Although DNA repair pathway alterations have been reported in many patients with BTC, little is known regarding the effects of DDR-targeted agents against BTC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.080DOI Listing

Computed-Tomography-Determined Sarcopenia is a Useful Imaging Biomarker for Predicting Postoperative Outcomes in Elderly Colorectal Cancer Patients.

Cancer Res Treat 2020 Apr 17. Epub 2020 Apr 17.

Deparment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Purpose: To establish whether computed tomography (CT)-determined sarcopenia is a useful imaging biomarker for postoperative outcome in elderly colorectal cancer (CRC) patients, and construct sarcopenia-based nomograms to predict individual outcomes after surgery.

Materials And Methods: CT imaging data of 298 elderly CRC patients who underwent surgery in 2012-2014 were retrospectively analyzed. Skeletal muscle mass was determined by CT, and sarcopenia was diagnosed based on the optimal cut-off value determined by X-tile program. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.695DOI Listing

Laparoscopic Surgery for Colorectal Cancer in Korea: Nationwide Data from 2013 to 2018.

Cancer Res Treat 2020 Apr 6. Epub 2020 Apr 6.

Department of Surgery, Kyung Hee University College of Medicine, Seoul, Korea.

Purpose: We report nationwide data on the current status of laparoscopic surgery for colorectal cancer (CRC) in Korea.

Materials And Methods: Nationwide data of patients who underwent surgery for CRC from 2013 to 2018 were obtained from the Health Insurance Review & Assessment Service database. Data and trends of laparoscopy use for colorectal resection over six years were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.043DOI Listing

Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma.

Cancer Res Treat 2020 Mar 30. Epub 2020 Mar 30.

Department of Interventional Oncology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Purpose: To investigate the clinicopathologic features and mutational landscape of patients with Hepatitis B virus (HBV)-related advanced hepatocellular carcinomas (HCC) undergoing transcatheter arterial chemoembolization (TACE).

Materials And Methods: From January 2017 to December 2018, 38 patients newly diagnosed with HBV-related advanced HCC were enrolled in the final analysis. Their pathological tissues and corresponding blood samples before TACE treatment were collected for whole-exome sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.533DOI Listing

Implication of the Life-Sustaining Treatment Decisions Act on End-of-Life Care for Korean Terminal Patients.

Cancer Res Treat 2020 Mar 23. Epub 2020 Mar 23.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Purpose: Life-sustaining treatment (LST) decisions for patients and caregivers at the end-of-life (EOL) process are supported by the "Act on Hospice and Palliative Care and Decisions on LST for Patients at the EOL," enforced in February 2018. It remains unclear whether the act changes EOL decisions and LST implementation in clinical practice. For this study, we investigated patients' decision-making regarding LSTs during the EOL process since the act's enforcement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.740DOI Listing

Socioeconomic Burden of Cancer in Korea from 2011 to 2015.

Cancer Res Treat 2020 Mar 18. Epub 2020 Mar 18.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.

Purpose: Though the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed the socioeconomic burden on cancer patients from 2011 to 2015 according to gender and age.

Materials And Methods: A prevalence-based approach was applied utilizing claim data of the National Health Insurance Service in Korea to estimate the socioeconomic burden of cancer on patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.398DOI Listing

Ramosetron versus Palonosetron in Combination with Aprepitant and Dexamethasone for the Control of Highly-Emetogenic Chemotherapy-Induced Nausea and Vomiting.

Cancer Res Treat 2020 Mar 18. Epub 2020 Mar 18.

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to compare ramosetron (RAM), aprepitant (APR), and dexamethasone (DEX) [RAD] with palonosetron (PAL), APR, and DEX [PAD] in controlling highly-emetogenic chemotherapy (HEC)-induced nausea and vomiting.

Materials And Methods: Patients were randomly assigned (1:1) to receive RAD or PAD:RAM (0.3 mg intravenously) or PAL (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.713DOI Listing

Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread.

Cancer Res Treat 2020 Mar 19. Epub 2020 Mar 19.

Department of Urology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.

We present a rare case of urothelial carcinoma in situ (CIS), which invades the prostate and seminal vesicle (SV). A 70-year-old man underwent transurethral resection of bladder (TURB), and the pathologic examination revealed multiple CIS. Although the patient received intravesical bacillus Calmette-Guerin (BCG) therapy following TURB, recurrence of CIS was confirmed in the bladder and left distal ureter at 3 months following BCG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.002DOI Listing

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017.

Cancer Res Treat 2020 Apr 16;52(2):335-350. Epub 2020 Mar 16.

Korea Central Cancer Registry, National Cancer Center, Goyang, Korea.

Purpose: This study reports the cancer statistics and temporal trends in Korea on a nationwide scale, including incidence, survival, prevalence, and mortality in 2017.

Materials And Methods: The incidence, survival, and prevalence rates of cancer were evaluated using data from the Korea National Cancer Incidence Database from 1999 to 2017 with follow-up until December 31, 2018. Deaths from cancer were assessed using cause-of-death data from 1983 to 2017, obtained from Statistics Korea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176962PMC

Prediction of Cancer Incidence and Mortality in Korea, 2020.

Cancer Res Treat 2020 Apr 16;52(2):351-358. Epub 2020 Mar 16.

Korea Central Cancer Registry, National Cancer Center, Goyang, Korea.

Purpose: This study aimed to report the projected cancer incidence and mortality for the year 2020 to estimate Korea's current cancer burden.

Materials And Methods: Cancer incidence data from 1999 to 2017 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2018 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years and then by multiplying the projected age-specific rates by the age-specific population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176954PMC

Establishment and Validation of a Nomogram for Nasopharyngeal Carcinoma Patients Concerning the Prognostic Effect of Parotid Lymph Node Metastases.

Cancer Res Treat 2020 Mar 10. Epub 2020 Mar 10.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Purpose: The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of PLN metastasis and develop a nomogram for estimating individual risk.

Materials And Methods: Clinical data of 7,084 non-metastatic NPC patients was retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.772DOI Listing

Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway.

Cancer Res Treat 2020 Mar 11. Epub 2020 Mar 11.

Department of Respiratory Medicine, The Affiliated Huadong Hospital of Fudan University, Shanghai, China.

Purpose: Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant pleural effusion compared with benign pleural effusion. So we investigated the role of CARD9 in non-small cell lung cancer (NSCLC) and its working mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.606DOI Listing

Prognostic Predictability of American Joint Committee on Cancer 8th Staging System for Perihilar Cholangiocarcinoma: Limited Improvement Compared with the 7th Staging System.

Cancer Res Treat 2020 Mar 12. Epub 2020 Mar 12.

Department of Hepatobiliary and Pancreatic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: This study was conducted to evaluate the prognostic values of the 7th and 8th American Joint Committee on Cancer (AJCC) staging systems for patients with resected perihilar cholangiocarcinoma (PHCC).

Materials And Methods: A total of 348 patients who underwent major hepatectomy for PHCC between 2008 and 2015 were identified from a single center. Overall survival (OS) was estimated using the Kaplan-Meier method and compared across stage groups with the log-rank test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.023DOI Listing

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ.

Cancer Res Treat 2020 Mar 4. Epub 2020 Mar 4.

Department of Immunology, School of Medicine, Nankai University, Tianjin, China.

Purpose: Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) and its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ in pro-tumorigenic effects induced by chronic stress in breast cancer remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.510DOI Listing

Soluble Axl Is a Novel Diagnostic Biomarker of Hepatocellular Carcinoma in Chinese Patients with Chronic Hepatitis B Virus Infection.

Cancer Res Treat 2020 Mar 5. Epub 2020 Mar 5.

Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.

Purpose: The purpose of this study was to evaluate the diagnostic value of soluble Axl (sAxl) in hepatocellular carcinoma (HCC) in comparison with serum α-fetoprotein (AFP).

Materials And Methods: Eighty HCC patients, 80 liver cirrhosis patients (LC), 80 patients with hepatitis B virus (HBV) infection, and 80 healthy controls (HC) were enrolled. sAxl levels were measured by an enzyme-linked immunosorbent assay (ELISA), serum AFP levels were measured by an electrochemiluminescence immunoassay (ECLIA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.749DOI Listing

G-Protein-Coupled Receptor 30 Mediates the Anticancer Effects Induced by Eicosapentaenoic Acid in Ovarian Cancer Cells.

Cancer Res Treat 2020 Mar 5. Epub 2020 Mar 5.

Biology Science Institutes, Chongqing Medical University, Yuzhong, China.

Purpose: While numerous epidemiological studies have indicated that omega-3 polyunsaturated fatty acids (PUFAs) have anticancer properties in various cancers, the effects and mechanisms of eicosapentaenoic acid (EPA) in ovarian cancer cell growth are poorly understood.

Materials And Methods: ES2 ovarian clear cell carcinoma cells and SKOV3 adenocarcinoma cells were treated with palmitic acid or eicosapentaenoic acid (EPA), followed by flow cytometry and cell counting to measure apoptosis and proliferation, respectively. A modified protein lipid overlay assay (PLO) was used t¬¬o further verify whether EPA was a ligand of GPR30 in ES2 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.380DOI Listing

Omega-3 and -6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women's Lifestyle and Health Cohort.

Cancer Res Treat 2020 Mar 6. Epub 2020 Mar 6.

International Agency for Research on Cancer, Lyon, France.

Purpose: We aimed to assess the association between the dietary intake of fish-derived omega-3 polyunsaturated fatty acids and the risk of colorectal cancer among Swedish women.

Materials And Methods: A total of 48,233 women with information on dietary intake were included in the analysis. Participants were followed for incident colorectal cancer until 31 December 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.550DOI Listing

Long Non-coding RNA CCAT1 Sponges miR-454 to Promote Chemoresistance of Ovarian Cancer Cells to Cisplatin by Regulation of Surviving.

Cancer Res Treat 2020 Mar 3. Epub 2020 Mar 3.

Department of Gynaecology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.

Purpose: Colon cancer-associated transcript 1 (CCAT1) was identified as an oncogenic long non-coding RNA (lncRNA) in a variety of cancers. However, there was a lack of understanding of the mechanism by which CCAT1 conferred cisplatin (also known as DDP) resistance in ovarian cancer cells.

Materials And Methods: Cell viability of A2780, SKOV3, A2780/DDP and SKOV3/DDP cells upon cisplatin treatment was monitored by MTT assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.498DOI Listing

Clinical Implications of Circulating Tumor DNA from Ascites and Serial Plasma in Ovarian Cancer.

Cancer Res Treat 2020 Feb 28. Epub 2020 Feb 28.

Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: The purpose of this study was to identify the clinical utility of circulating tumor DNA (ctDNA) from ascites and serial plasma samples from epithelial ovarian cancer (EOC) patients.

Materials And Methods: Using targeted next-generation sequencing, we analyzed a total of 55 EOC samples including ctDNA from ascites and serial plasma and gDNA from tumor tissues. Tumor tissues and ascites were collected during debulking surgeries and plasma samples were collected before and after the surgeries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.700DOI Listing
February 2020

T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity.

Cancer Res Treat 2020 Feb 14. Epub 2020 Feb 14.

Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Successful tumor eradication primarily depends on generation and maintenance of a large population of tumor-reactive CD8 T cells. Dendritic cells (DCs) are well-known potent antigen-presenting cells and have applied to clinics as potent antitumor therapeutic agents. However, high cost and difficulty in obtaining sufficient amounts for clinical use are the crucial drawbacks of DC-based vaccines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.721DOI Listing
February 2020

Clinical Implication of Concordant or Discordant Genomic Profiling Between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer.

Cancer Res Treat 2020 Feb 17. Epub 2020 Feb 17.

Division of Oncology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the clinical implication.

Materials And Methods: Surgical samples of primary and matched metastatic tissues from 158 patients (335 samples) with CRC at Korea University Anam Hospital were evaluated using the Ion AmpliSeq Cancer Hotspot Panel. We compared genetic variants and classified them as concordant, primary-specific, and metastasis-specific variants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2020.044DOI Listing
February 2020
2.975 Impact Factor

Public Attitudes Towards Cancer Survivors Among Korean Adults.

Cancer Res Treat 2020 Feb 6. Epub 2020 Feb 6.

Division of Cancer Control & Policy, National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Purpose: We evaluated public attitudes towards cancer survivors and identified the characteristics associated with these attitudes in Korea.

Materials And Methods: We performed this cross-sectional study using proportionate quota random sampling of the 2015 Korean Census. In May 2017, investigators conducted face-to-face interviews with 1,500 Korean volunteers aged between 20 and 79 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.265DOI Listing
February 2020

Diagnostic Accuracy and Value of Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Targeted and Template Systematic Prostate Biopsy Based on Bi-parametric Magnetic Resonance Imaging.

Cancer Res Treat 2020 Feb 10. Epub 2020 Feb 10.

Department of Urology, Korea University School of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to investigate the diagnostic value of magnetic resonance imaging (MRI)-ultrasound (US) fusion transperineal targeted biopsy (FTB) and template systematic biopsy (FSB) for prostate cancer (PCa) and clinically significant prostate cancer (csPCa) (intermediate/high grade [Gleason score ≥ 3 + 4]) based on bi-parametric MRI (bpMRI).

Materials And Methods: Retrospectively, we analyzed 300 patients with elevated prostate-specific antigen (≥ 4.0 ng/mL) and/or abnormal findings in a digital rectal examination (DRE) at the Korea university Hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.716DOI Listing
February 2020

Clinical Outcomes of Immune Checkpoint Blocker Therapy for Malignant Melanoma in Korean Patients: Potential Clinical Implications for a Combination Strategy Involving Radiotherapy.

Cancer Res Treat 2020 Feb 13. Epub 2020 Feb 13.

Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We investigated the clinical efficacy of immune checkpoint blocker (ICB) therapy for metastatic or advanced melanoma in Korean patients. As well, we assessed whether the effects of ICBs can be enhanced by combination therapy with palliative radiotherapy (RT).

Materials And Methods: We retrospectively reviewed the records of 127 patients with metastatic melanoma who received ICB with or without palliative RT between 2014 and 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.598DOI Listing
February 2020
2.975 Impact Factor

Comparing the Characteristics and Outcomes of Male and Female Breast Cancer Patients in Korea: Korea Central Cancer Registry.

Cancer Res Treat 2020 Feb 13. Epub 2020 Feb 13.

Center for Breast Cancer, National Cancer Center, Goyang, Korea.

Purpose: This study aimed to determine the incidence of male breast cancer (MBC) and its survival outcomes in Korea, and to compare these results to those for female breast cancer (FBC).

Materials And Methods: We searched the Korea Central Cancer Registry and identified 227,122 breast cancer cases that were diagnosed between 1999 and 2016. Demographic and clinical characteristics and overall survival (OS) rates were estimated according to sex, age, histological type, and cancer stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.639DOI Listing
February 2020

A Modified NHL-BFM-95 Regimen Produces Better Outcome Than HyperCVAD in Adult Patients with T-Lymphoblastic Lymphoma, a Two-Institution Experience.

Cancer Res Treat 2020 Apr 6;52(2):573-585. Epub 2019 Dec 6.

Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Purpose: Lymphoblastic lymphoma (LBL) is an invasive neoplasm of precursor T-cell or B-cell lineage. A broadly accepted standard treatment for adult LBL has not yet been defined.

Materials And Methods: To address this issue, we compared two chemotherapy regimens: a modified non-Hodgkin lymphoma Berlin-Frankfurt-Münster-95 (NHL-BFM-95) regimen and HyperCVAD/MA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176963PMC
April 2020
2.975 Impact Factor

Risk Factors for Cognitive Impairment in High-Grade Glioma Patients Treated with Postoperative Radiochemotherapy.

Cancer Res Treat 2020 Apr 12;52(2):586-593. Epub 2019 Dec 12.

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.

Purpose: Fractionated radiotherapy as well as concomitant and adjuvant chemotherapy such as temozolomide for postoperative high-grade glioma (HGG) patients improves progression-free survival and overall survival. Multiple factors such as chemotherapy, radiotherapy, tumor grade, residual tumor volume, and genetic modifications might play a role in the formation of cognitive impairment. The risk factors of cognitive impairment in postoperative patients with HGG receiving radiotherapy and chemotherapy remains a concern in this population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176951PMC

Efficacy and Safety of Pembrolizumab in Patients with Refractory Advanced Biliary Tract Cancer: Tumor Proportion Score as a Potential Biomarker for Response.

Cancer Res Treat 2020 Apr 18;52(2):594-603. Epub 2019 Dec 18.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: The current standard chemotherapy for advanced biliary tract cancer (BTC) has limited benefit, and novel therapies need to be investigated.

Materials And Methods: In this prospective cohort study, programmed death ligand-1 (PD-L1)-positive BTC patients who progressed on first-line gemcitabine plus cisplatin were enrolled. Pembrolizumab 200 mg was administered intravenously every 3 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4143/crt.2019.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176957PMC