2,326 results match your criteria Cancer Radiotherapie[Journal]


Prostate imaging: Contribution of PET PSMA and MRI.

Cancer Radiother 2020 Jun 30. Epub 2020 Jun 30.

Université de Paris, 85, boulevard Saint-Germain, 75006 Paris, France; Service d'oncologie radiothérapie, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France. Electronic address:

Prostate cancer is the most common malignant tumour and represents the third cause of cancer-mortality in men. The management of prostate cancer has dramatically changed over the last decades, mainly due to improvement of diagnostic modalities and development of new therapeutic strategies. Imaging plays a key role in all the steps of prostate cancer management. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.06.002DOI Listing

[Anatomical and functional imaging for radiotherapy planning].

Cancer Radiother 2020 Jun 30. Epub 2020 Jun 30.

Service de radiologie, hôpital européen Georges-Pompidou, centre université de Paris, AP-HP, 20, rue Leblanc, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.canrad.2020.06.001DOI Listing

Correlation between fluorodeoxyglucose hotspots on preradiotherapy PET/CT and areas of cancer local relapse: Systematic review of literature.

Cancer Radiother 2020 Jun 30. Epub 2020 Jun 30.

Service de radiothérapie, CHU de Brest, 2, avenue Foch, 29200 Brest, France.

The aim of the present paper is to systematically review all available literature on preradiotherapy high uptake areas (hotspots) as a potential target for dose escalation in different tumour sites, and to understand the potential role and limitations of fluorodeoxyglucose (FDG)-positron-emission tomography (PET)/computed tomography (CT) in this context. An electronic database (Medline) search was conducted to identify articles reporting on a correlation between high tracer uptake on pretreatment PET and preferential sites of local recurrence after radiotherapy. Search was limited to English language. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.010DOI Listing

[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curiethérapie de la SFRO].

Cancer Radiother 2020 Jun 20. Epub 2020 Jun 20.

Département de radiothérapie oncologique, institut de cancérologie de Lorraine Alexis-Vautrin, avenue de Bourgogne, 54511 Vandœuvre-lès-Nancy, France.

Because of its principle and its high proof level clinical results, brachytherapy represents a specific irradiation technique for the treatment of primary tumors as well as some local relapses in pre-irradiated area. After a glory period between the 80's and 90's, brachytherapy has progressively lost its attractiveness. In order to provide a practical solution to this deleterious situation, it is important that guardianships, health care payers, patient associations, specialist doctors and radiation oncologists understand the reasons leading to this harmful state as well as the risks concerned. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.03.010DOI Listing

Hyaluronic acid spacer in focal prostate reirradiation: A single centre experience.

Cancer Radiother 2020 Jun 18. Epub 2020 Jun 18.

Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: The optimal management of locally recurrent prostate cancer after curative radiotherapy is still unknown. In this study, we evaluated the preliminary results of reirradiation using stereotactic body radiotherapy for locally recurrent prostate cancer after initial definitive local radiotherapy.

Materials And Methods: Between April 2016 and February 2019, 11 patients with recurrent disease at the previously irradiated prostate were treated. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.03.009DOI Listing

Radiological assessment after stereotactic body radiation of lung tumours.

Cancer Radiother 2020 Jun 10. Epub 2020 Jun 10.

Service de radiologie, hôpital Cochin, AP-HP, centre université de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université de Paris, 12, rue de l'École-de-Médecine, 75006 Paris, France.

The increasing use of stereotactic body radiation therapy for lung tumours comes along with new post-therapeutic imaging findings that should be known by physicians involved in patient follow-up. Radiation-induced lung injury is much more frequent than after conventional radiation therapy, it can also be delayed and has a different radiological presentation. Radiation-induced lung injury after stereotactic body radiation therapy involves the lung parenchyma surrounding the target tumour and appears as a dynamic process continuing for years after completion of the treatment. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.009DOI Listing

Diagnostic performance of imaging techniques for detecting of local recurrence after prostate brachytherapy.

Cancer Radiother 2020 Jul 10;24(4):323-331. Epub 2020 Jun 10.

Department of Radiation Oncology, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.

Purpose: The purpose of this study was to evaluate MRI and fluorocholine PET/CT diagnostic performances for the detection of local recurrence following prostate brachytherapy for localised prostate cancer.

Material And Methods: In this single-centre study, we retrospectively reviewed data from 21 patients treated by brachytherapy for localised prostate cancer and diagnosed with biochemical recurrence according to Phoenix Criteria, who underwent MRI and fluorocholine PET/CT. We included patients with local relapse suspicion according to imaging exams, with biopsy for the final assessment of local recurrence. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.03.008DOI Listing

Interventional radiology for treatment of bone metastases.

Authors:
G Hayek B Kastler

Cancer Radiother 2020 Jun 8. Epub 2020 Jun 8.

Service de radiologie, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Unité mixte de recherche, université de Paris, 56, rue Leblanc, 75015 Paris, France; Paris-Centre de recherche cardiovasculaire (PARCC), 56, rue Leblanc, 75015 Paris, France; Inserm, unité mixte de recherche, 56, rue Leblanc, 75015 Paris, France; Service de radiologie adulte, hôpital Necker, AP-HP, 149, rue de Sèvres, 75015 Paris, France.

Therapeutic advances in oncology have led to longer survival in many forms of cancer, including those complicated by bone metastases. When a bone metastasis is painful or when there is a risk of fracture, interventional radiology procedures can be carried out for pain control and/or stabilisation. All of these techniques can be performed under local anaesthesia. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.006DOI Listing

Multimodal imaging in radiotherapy: Focus on adaptive therapy and quality control.

Cancer Radiother 2020 Jun 6. Epub 2020 Jun 6.

Medical Physics Department, CHU de Lille, 59037 Lille, France; Neurosurgery Department, hôpital Roger-Salengro, CHU de Lille, 59037 Lille, France; Nuclear Medicine Department, hôpital Roger-Salengro, CHU de Lille, 59037 Lille, France; Université de Lille, 59000 Lille, France; Inserm, U1189, 59000 Lille, France; ONCO-THAI-Image-Assisted Laser Therapy for Oncology, CHU de Lille, 59000 Lille, France. Electronic address:

Improved computer resources in radiation oncology department have greatly facilitated the integration of multimodal imaging into the workflow of radiation therapy. Nowadays, physicians have highly informative imaging modalities of the anatomical region to be treated. These images contribute to the targeting accuracy with the current treatment device, impacting both segmentation or patient's positioning. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.007DOI Listing

Methods to delineate tumour for radiotherapy by fluorodeoxyglucose positron emission tomography.

Authors:
Isabelle Gardin

Cancer Radiother 2020 Jun 4. Epub 2020 Jun 4.

Service de médecine nucléaire, centre Henri-Becquerel, 1, rue d'Amiens, 76000 Rouen, France; Litis (EA 4108), université de Rouen Normandie, 685, avenue de l'Université, 76800 Saint-Étienne-du-Rouvray, France. Electronic address:

Numerous articles have been published showing the interest to delineate tumours using fluorodeoxyglucose positron emission tomography/computed tomography images in radiotherapy planning. This imaging is used to identify tumour tissues with increased glucose metabolism compared to healthy surrounding tissues. This volume corresponds to the metabolic tumour volume. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.008DOI Listing

[Research ethics: French regulations and applications in radiation oncology].

Cancer Radiother 2020 Jul 1;24(4):306-315. Epub 2020 Jun 1.

Service de pharmacologie médicale, comité de protection des personnes Sud-Ouest et outre-mer III, hôpital Pellegrin, centre hospitalier universitaire de Bordeaux, 33076 Bordeaux, France; Faculté de pharmacie, université de Bordeaux, 146, rue Léo-Saignat, 33076 Bordeaux, France.

French regulations about research ethics are based on the so-called Jardé law, which defines researches involving human beings. Researches involving human beings require the submission of research protocols to a committee for protection of persons with a precise list of documents to submit for a favourable opinion. This law describes different categories of researches and determines the ethical procedures to apply before setting up a research protocol. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.012DOI Listing

Collision prediction for intracranial stereotactic radiosurgery planning: An easy-to-implement analytical solution.

Cancer Radiother 2020 Jul 25;24(4):316-322. Epub 2020 May 25.

Department of Radiation Oncology, Hôtel-Dieu de France University Hospital, School of Medicine, Saint Joseph University, Beirut, Lebanon.

Purpose: Gantry collision is a concern in linac-based stereotactic radiosurgery (SRS). Without collision screening, the planner may compromise optimal planning, unnecessary re-planning delays can occur, and incomplete treatments may be delivered. To address these concerns, we developed a software for collision prediction based on simple machine measurements. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.003DOI Listing

Benefits of positron emission tomography scans for the evaluation of radiotherapy.

Cancer Radiother 2020 May 21. Epub 2020 May 21.

Département de médecine nucléaire, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France; QuantIF-Litis, EA 4108, faculté de médecine, université de Rouen, 22, boulevard Gambetta, 76000 Rouen, France.

The assessment of tumour response during and after radiotherapy determines the subsequent management of patients (adaptation of treatment plan, monitoring, adjuvant treatment, rescue treatment or palliative care). In addition to its role in extension assessment and therapeutic planning, positron emission tomography combined with computed tomography provides useful functional information for the evaluation of tumour response. The objective of this article is to review published data on positron emission tomography combined with computed tomography as a tool for evaluating external radiotherapy for cancers. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.007DOI Listing

Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment.

Authors:
J-P Jay-Gerin

Cancer Radiother 2020 Jul 20;24(4):332-334. Epub 2020 May 20.

Département de médecine nucléaire et de radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, Québec, J1H 5N4, Canada. Electronic address:

Monte Carlo simulations of γ/fast electron-radiolysis of water show that the in situ formation of HO temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient "acid-spike" response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.11.004DOI Listing

[MRI can be prescribed in patients with implanted cardiac devices (pacemaker, defibrillator) to optimize radiotherapy planning].

Cancer Radiother 2020 Jul 19;24(4):340-344. Epub 2020 May 19.

Département de radiothérapie. centre François-Baclesse, ARCHADE, 3, avenue General-Harris, 14000 Caen, France; Laboratoire de physique corpusculaire, IN2P3/ENSICAEN, UMR6534, Caen, France; Unicaen, Normandie université. Electronic address:

Purpose: MRI is sometimes critical to optimal radiotherapy planning but may be contraindicated in increasing numbers of patients who carry an implantable cardiac device (ICD, pacemaker or defibrillator).

Material And Methods: This literature search reviews studies of MRI in DCI patients, morbidity and procedures for the different types of ICD.

Results: Several retrospective studies and two recent large prospective studies have shown that the use of an ICD is not an absolute contraindication to MRI, given that specific DCI monitoring is performed under the tridisciplinary supervision of the oncologist, radiologist and cardiologist for MRI≤1. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.12.001DOI Listing

Hodkgin lymphoma concomitant of tuberculosis, a therapeutic challenge for multidisciplinary management.

Cancer Radiother 2020 Jul 19;24(4):335-339. Epub 2020 May 19.

Department of Radiation Oncology, Institut Curie, 25, rue d'Ulm, 75005 Paris, France; University of Versailles, St Quentin, France.

Hodgkin lymphoma (HL) is a disease characterized by a high curability rate, and the treatment benefit-risk balance must be carefully addressed to achieve complete disease control with low risk of long-term toxicities. Most patients are treated with a combination of chemotherapy and radiotherapy, after disease staging and response to treatment evaluated by FDG PET/CT. We report the case of a 28-year-old patient concomitantly diagnosed of a Hodgkin lymphoma and active tuberculosis. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.005DOI Listing

Outcomes of concurrent radiotherapy with weekly docetaxel and platinum-based chemotherapy in stage III non-small-cell lung cancer.

Cancer Radiother 2020 Jul 18;24(4):279-287. Epub 2020 May 18.

Department of radiation oncology, Cancer Center GF Leclerc, Dijon, France.

Purpose: The present study evaluated the outcomes of concurrent weekly docetaxel and platinum-based drug doublet in association with concurrent thoracic radiotherapy (TR) in the curative treatment of stage III locally advanced non-small-cell lung cancer (NSCLC).

Patients And Methods: Patients with stage IIIA/B NSCLC were retrospectively included. Patients received weekly docetaxel and either cisplatin or carboplatin intravenous injections during concurrent TR (60 to 66Gy). Read More

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http://dx.doi.org/10.1016/j.canrad.2019.09.009DOI Listing

[Practical guidelines for the radiotherapy for patients presented with haematological malignancies in the epidemic COVID-19 situation: International Lymphoma Radiation Oncology Group recommendations].

Authors:
Y Kirova

Cancer Radiother 2020 06 4;24(3):194-195. Epub 2020 May 4.

Département de radiothérapie-oncologie, institut Curie, 25, rue d'Ulm, 75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.canrad.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198151PMC

[Breast radiation therapy during COVID-19 outbreak: Practical advice].

Cancer Radiother 2020 06 4;24(3):196-198. Epub 2020 May 4.

Département de radiothérapie-oncologie, institut Curie, 25, rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.canrad.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198159PMC

[Low dose lung radiotherapy for COVID-19-related cytokine storm syndrome: Why not?]

Cancer Radiother 2020 06 1;24(3):179-181. Epub 2020 May 1.

Département d'oncologie radiothérapie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94600 Villejuif, France; Inserm, U1030 radiothérapie moléculaire et innovations thérapeutiques, 114, rue Édouard-Vaillant, 94805 Villejuif, France; Université Paris-Saclay, 114, rue Édouard-Vaillant, 94805 Villejuif, France; Service de santé des armées, école du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France; Institut de recherche biomédicale des armées, D19, 91220 Bretigny-sur-Orge, France.

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http://dx.doi.org/10.1016/j.canrad.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252150PMC

[Preoperative intensity-modulated radiotherapy of rectal cancers: Relevance and modalities].

Cancer Radiother 2020 Jul 28;24(4):345-353. Epub 2020 Apr 28.

Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France. Electronic address:

Preoperative radiotherapy boosted by chemotherapy is a recommended treatment in locally advanced rectal cancers. This treatment is delivered by three dimensional conformal irradiation, which is usually well tolerated but can induce potential toxicity such as rectitis, cystitis and hematologic adverse effects. Intensity-modulated radiotherapy, widely available nowadays, allows optimization of volume covering and sparing of organs at risk such as bladder and bone marrow. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.11.005DOI Listing

Diffusion MRI: Technical principles and application to uterine cervical cancer.

Cancer Radiother 2020 Apr 28. Epub 2020 Apr 28.

Radiation Oncology Department, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France.

Imaging is involved in the management of uterine cervical cancer with several objectives: 1/to assess local and lymph node extension of the initial disease; 2/evaluate treatment response to conservative therapy; 3/detect recurrences. Pelvic MRI is the first-line examination in all these indications. It is the key element for delineation after image fusion when the indication of chemoradiation therapy is made. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.008DOI Listing

[Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)].

Cancer Radiother 2020 Jun 17;24(3):188-193. Epub 2020 Apr 17.

Service de radiothérapie, hôpital Émile-Muller, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.

The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of patients treated and staff present. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164904PMC

[Practical update of total dose compensation in case of temporary interruption of external radiotherapy in the COVID-19 pandemic context].

Cancer Radiother 2020 Jun 10;24(3):182-187. Epub 2020 Apr 10.

Service d'oncologie radiothérapie, AP-HP, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université de Paris, 20, rue Leblanc, 75015 Paris, France.

Overall treatment time is an important factor of local recurrence and indirectly of distant evolution, namely in case of protracted treatments. The current pandemic impacts on the duration of radiotherapy if patients under treatments and synchronously suffering from COVID-19. The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146696PMC

Impact of positron emission tomography with computed tomography for image-guided radiotherapy.

Cancer Radiother 2020 Apr 10. Epub 2020 Apr 10.

Department of Nuclear Medicine Cancer, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France; Laboratoire QuantIF EA4108-Litis, université de Rouen, Rouen, France; Faculty of Medicine, université de Rouen Normandie, rue d'Amiens, 76000 Rouen, France.

Therapeutic effectiveness in radiotherapy is partly related to correct staging of the disease and then precise therapeutic targeting. Positron emission tomography (PET) allows the stage of many cancers to be determined and therefore is essential before deciding on radiation treatment. The definition of the therapeutic target is essential to obtain correct tumour control and limit side effects. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.03.006DOI Listing

Anatomical and functional MR imaging to define tumoral boundaries and characterize lesions in neuro-oncology.

Cancer Radiother 2020 Apr 8. Epub 2020 Apr 8.

Radiology Department, GHU de Paris, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France; Université de Paris, 85, boulevard Saint-Germain, 75006 Paris, France; Imabrain, Institut de psychiatrie et neurosciences de Paris (IPNP), 102-108, rue de la Santé, 75014 Paris, France; Inserm, U1266, 102, rue de la Santé, 75013 Paris, France.

Neuroimaging and especially MRI has emerged as a necessary imaging modality to detect, measure, characterize and monitor brain tumours. Advanced MRI sequences such as perfusion MRI, diffusion MRI and spectroscopy as well as new post-processing techniques such as automatic segmentation of tumours and radiomics play a crucial role in characterization and follow up of brain tumours. The purpose of this review is to provide an overview on anatomical and functional MRI use for brain tumours boundaries determination and tumour characterization in the specific context of radiotherapy. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.03.005DOI Listing

How to work together between nuclear medicine and radiotherapy departments?

Cancer Radiother 2020 Apr 8. Epub 2020 Apr 8.

CNRS, EA4108-Litis, FR UMR 3638, laboratoire QuantIF, 1, rue d'Amiens, 76000 Rouen, France; Department of Radiation Oncology, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France.

Among the available imaging techniques, functional imaging provided by nuclear medicine departments represents a tool of choice for the oncoradiotherapist for targeting tumour activity, with positron emission tomography as the main modality. Before, during or after radiotherapy, functional imaging helps guide the oncoradiotherapist in making decisions and in the strategic choice of pathology management. Setting up a working group to ensure perfect coordination at all levels is the first step. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.011DOI Listing

Radiomics: A primer for the radiation oncologist.

Cancer Radiother 2020 Apr 4. Epub 2020 Apr 4.

Radiation Oncology Department, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université de Paris, 85, boulevard Saint-Germain, 75006 Paris, France.

Purpose: Radiomics are a set of methods used to leverage medical imaging and extract quantitative features that can characterize a patient's phenotype. All modalities can be used with several different software packages. Specific informatics methods can then be used to create meaningful predictive models. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.011DOI Listing

Positron-emission tomography-guided radiation therapy: Ongoing projects and future hopes.

Cancer Radiother 2020 Apr 1. Epub 2020 Apr 1.

Nuclear Medicine Department, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France.

Radiation therapy has undergone significant advances these last decades, particularly thanks to technical improvements, computer science and a better ability to define the target volumes via morphological and functional imaging breakthroughs. Imaging contributes to all three stages of patient care in radiation oncology: before, during and after treatment. Before the treatment, the choice of optimal imaging type and, if necessary, the adequate functional tracer will allow a better definition of the volume target. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.009DOI Listing

Interest of positron-emission tomography and magnetic resonance imaging for radiotherapy planning and control.

Cancer Radiother 2020 Apr 1. Epub 2020 Apr 1.

Département de radiothérapie et de physique médicale, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France; Quantif-Litis EA4108, université de Rouen Normandie, rue d'Amiens, 76000 Rouen, France; Département d'imagerie-médecine nucléaire, centre Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France; Laboratoire de physique corpusculaire, Institut national de physique nucléaire et de physique des particules (IN2P3), 6, boulevard Maréchal-Juin, 14000 Caen, France. Electronic address:

Computed tomography (CT) in the treatment position is currently indispensable for planning radiation therapy. Other imaging modalities, such as magnetic resonance imaging (MRI) and positron emission-tomography (PET), can be used to improve the definition of the tumour and/or healthy tissue but also to provide functional data of the target volume. Accurate image registration is essential for treatment planning, so MRI and PET scans should be registered at the planning CT scan. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.010DOI Listing

Imaging issues specific to hadrontherapy (proton, carbon, helium therapy and other charged particles) for radiotherapy planning, setup, dose monitoring and tissue response assessment.

Cancer Radiother 2020 Apr 1. Epub 2020 Apr 1.

Université de Caen Normandie (Unicaen), esplanade de la Paix, CS 14032, 14032 Caen cedex, France; Normandie Université, esplanade de la Paix, CS 14032, 14032 Caen cedex, France; Commissariat à l'énergie atomique (CEA), boulevard Henri-Becquerel, 14000 Caen, France; CNRS, UMR 6030 ISTCT, Equipe CERVOxy, boulevard Henri-Becquerel, 14000 Caen, France; CervOxy group, groupement d'intérêt public Cyceron, boulevard Henri-Becquerel, 14000 Caen, France.

Imaging is critical to each step of precision radiation therapy, i.e. planning, setup, delivery and assessment of response. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.010DOI Listing

[Treatment de-intensification strategies for HPV-driven oropharyngeal cancer: A short review].

Cancer Radiother 2020 Jun 27;24(3):258-266. Epub 2020 Mar 27.

Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, Saint-Priest-en-Jarez, France. Electronic address:

The incidence of oropharyngeal cancer induced by human papillomavirus (HPV) infection is steadily increasing in developed countries. These tumors are more chemoradiosensitive and have a better prognosis than HPV-negative one. In addition, they occur in younger and better-off patients with longer life expectancy. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.12.003DOI Listing

Monte Carlo dose calculations of shielding disks with different material combinations in intraoperative electron radiation therapy (IOERT).

Cancer Radiother 2020 Apr 26;24(2):128-134. Epub 2020 Mar 26.

Radiothérapy Department, institut Jules-Bordet, Bruxelles, Belgium.

Purpose: Shielding disks play an important role in intraoperative electron radiation therapy, and different designs are currently used in clinical practice. This paper investigates the dosimetric impact of the shielding disk used during intraoperative electron radiation therapy (IOERT).

Materials And Methods: This paper focuses on the study of four shielding disks types that have been used in our clinic: Aluminum (Al)/Lead (Pb), PMMA/Copper(Cu)/PMMA, Aluminum (Al)/Copper (Cu) and Aluminum (Al)/Steel with their specific thicknesses. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.006DOI Listing

[Construction of radiobiological models as TCP (tumor control probability) and NTCP (normal tissue complication probability): from dose to clinical effects prediction].

Cancer Radiother 2020 Jun 24;24(3):247-257. Epub 2020 Mar 24.

Laboratoire de physique corpusculaire IN2P3/ENSICAEN - UMR6534, Unicaen, Normandie université, Caen, France.

In radiotherapy, the dose prescription is currently based on discretized dose-effects records that do not take into fully account for the complexity of the patient-dose-response relationship. Their predictive performance on both anti-tumour efficacy and toxicity can be optimized by integrating radiobiological models. It is with this in mind that the calculation models TCP (Tumor Control Probability) and NTCP (Normal Tissue Complication Probability) have been developed. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.12.004DOI Listing

[Functional stereotactic radiosurgery: Indications and perspectives].

Cancer Radiother 2020 Apr 24;24(2):166-173. Epub 2020 Mar 24.

Département de neurochirurgie, centre hospitalier universitaire Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.

Stereotactic radiosurgery (SRS) is a non-invasive technique that enables to create brain focal lesions with a high precision and localization. Thus, functional brain disorders can be treated by SRS in case of pharmacoresistance or inoperability. To date, treatment of trigeminal neuralgia is the most described and known indication. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.009DOI Listing

Kilovoltage intrafraction monitoring during normofractionated prostate cancer radiotherapy.

Cancer Radiother 2020 Apr 19;24(2):99-105. Epub 2020 Mar 19.

Radiation Oncology Department, CHU de Brest, Brest, France; LaTIM, INSERM, UMR 1101, CHRU de Brest, Brest, France; Faculté de médecine et des sciences de la santé, université de Bretagne Occidentale, Brest, France. Electronic address:

Purpose: During radiotherapy (RT) for prostate cancer (PCa), interfraction and intrafraction movements can lead to decreased target dose coverage and unnecessary over-exposure of organs at risk. New image-guided RT techniques accuracy allows planning target volume (PTV) margins reduction. We aim to assess the feasibility of a kilovoltage intrafraction monitoring (KIM) to track the prostate during RT. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.11.001DOI Listing

Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches.

Cancer Radiother 2020 Jun 17;24(3):226-246. Epub 2020 Mar 17.

UT Health HOPE Cancer Center, Tyler, TX 75701, USA.

We report the case of an 84-year-old woman with poorly differentiated non-small cell carcinoma of the right parotid who presented with headache, was found to have a primary right parotid gland cancer as well as metastatic disease, and underwent palliative radiotherapy to the primary site. The patient received no chemotherapy or immunotherapy, but both the primary site and several non-irradiated foci in the lungs regressed or completely resolved. The patient remained free of disease for about one year before progression. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.001DOI Listing

[Prognosis factors after lung stereotactic body radiotherapy for non-small cell lung carcinoma].

Cancer Radiother 2020 Jun 16;24(3):267-274. Epub 2020 Mar 16.

ORLAM, centre de radiothérapiede l'ouest lyonnais Charcot, 11, avenue Maréchal-Foch, 69110 Sainte-Foy-Lès, Lyon, France; ORLAM, centre de radiothérapie Mermoz, Lyon, France; ORLAM, centre de radiothérapie et oncologie, Macon, France; ORLAM, centre de radiothérapie Bayard, Villeurbanne, France.

Lung cancer is the fourth most common cancer in France with a prevalence of 30,000 new cases per year. Lobectomy surgery with dissection is the gold standard treatment for T1-T2 localized non-small cell lung carcinoma. A segmentectomy may be proposed to operable patients but fragile from a respiratory point of view. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.11.002DOI Listing

Head-and-Neck MRI-only radiotherapy treatment planning: From acquisition in treatment position to pseudo-CT generation.

Cancer Radiother 2020 Jul 14;24(4):288-297. Epub 2020 Mar 14.

Université de Rennes, CLCC Eugène-Marquis, Inserm, LTSI-UMR 1099, 35000 Rennes, France.

Purpose: In context of head-and-neck radiotherapy, this study aims to compare MR image quality according to diagnostic (DIAG) and radiotherapy (RT) setups; and to optimise an MRI-protocol (including 3D T and T-weighted sequences) for dose-planning (based on pseudo-CT generation).

Materials And Methods: To compare DIAG and RT setups, signal-to-noise-ratio (SNR) and percentage-image-uniformity (PIU) were computed on T images of phantoms and volunteers. Influence of the sample conductivity on SNR was quantified using homemade phantoms. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.008DOI Listing

Surgical bed stereotactic radiotherapy of brain metastases: Clinical outcome and predictors of local and distant brain failure.

Cancer Radiother 2020 Jul 12;24(4):298-305. Epub 2020 Mar 12.

Radiation Oncology, université catholique de Louvain, CHU-UCL-Namur, site Sainte-Elisabeth, Namur, Belgium; Radiation Oncology Department, Katholieke Universiteit Leuven, Universitaire Ziekehnhuis, Leuven, Belgium.

Purpose: To retrospectively analyze the outcomes of stereotactic radiotherapy (SRT) targeted at surgical bed of brain metastases (BM) and identify patterns of local/distant brain relapses (LR/DBR).

Patients/methods: Seventy patients were treated with SRT between 2008-2017. Marginal dose prescription on the 70% isodose line depended on the maximal diameter of the target volume and range between 15-18Gy for single fraction radiosurgery and 23. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.12.002DOI Listing

Radiation-induced lung toxicity predictors: Retrospective analysis of 90 patients treated with stereotactic body radiation therapy for stage I non-small-cell lung carcinoma.

Cancer Radiother 2020 Apr 12;24(2):120-127. Epub 2020 Mar 12.

Department of Radiotherapy, Paul Strauss Center, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; CNRS, IPHC UMR 7178, université de Strasbourg, Centre Paul-Strauss, institut régional de cancérologie, UNICANCER, 67000 Strasbourg, France.

Background: The main complication after hypofractionated radiotherapy for lung carcinoma is radiation-induced lung toxicity, which can be divided into radiation pneumonitis (acute toxicity, occurring within 6 months) and lung fibrosis (late toxicity, occurring after 6 months). The literature describes several predictive factors related to the patient, to the tumor (volume, central location), to the dosimetry and to biological factors.

Materials And Methods: This study is a retrospective analysis of 90 patients treated with stereotactic body irradiation for stage I non-small-cell lung carcinoma between December 2010 and May 2015. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.11.003DOI Listing

A brief history of contact X-ray brachytherapy 50 kVp.

Cancer Radiother 2020 Jun 11;24(3):222-225. Epub 2020 Mar 11.

Centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.

Contact X ray brachytherapy 50 kVp was initiated in the 1930s with the Siemens unit and popularized with the Philips unit in the 1950s. A renaissance was seen in the early 2000s with the Intrabeam™ unit for breast IORT. Presently the Papillon™ systems thanks to its high dose rate (>10Gy/mn) can be used to treat breast (IORT), skin, eyelid and rectal cancers. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.002DOI Listing

Intraoperative partial irradiation for highly selected patients with breast cancer: Results of the INTRAOBS prospective study.

Cancer Radiother 2020 Apr 11;24(2):114-119. Epub 2020 Mar 11.

Department of Surgical and Reconstructive Oncology, ICM-Val d'Aurelle, université Montpellier, Montpellier, France.

Purpose: To evaluate our long-term experience on one-day breast intraoperative radiotherapy (IORT) given as sole radiation treatment to selected patients with breast cancer.

Methods And Materials: Inclusion criteria of INTRAOBS study (prospective observational study) were: ER+ T1N0 unifocal ductal carcinoma; absence of lymphovascular invasion or of extensive intraductal component (Scarff-Bloom-Richardson grade III and HER2+++ excluded). Two different linacs were used (20Gy/1 fraction): one dedicated electron linac (Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.007DOI Listing

Adolescents and young adults with classical Hodgkin lymphoma in northern Tunisia: insights from an adult single-institutional study.

Cancer Radiother 2020 Jun 11;24(3):206-214. Epub 2020 Mar 11.

Department of Medical Oncology, Salah Azaiez Institute, 1006 Tunis, Tunisia.

Purpose: The aim of this study was to extensively describe the epidemiological, clinical and therapeutic outcomes of adolescents and young adults (AYA) population with classical Hodgkin Lymphoma (cHL). Then, a comparison between AYAs and adults and between the subgroups of AYAs treated with the same adult protocol was accomplished to further inform on optimal therapy approach of choice for adolescent patients.

Material And Methods: In this mono-centric, retrospective study, we reviewed the medical records. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.004DOI Listing

Independent 6D quality assurance of stereotactic radiotherapy repositioning on linacs.

Cancer Radiother 2020 Jun 9;24(3):199-205. Epub 2020 Mar 9.

Service de physique médicale, département de radiothérapie, Institut Curie, 26 rue d'ULM, site de Paris 75005 Paris, France.

Purpose: A high level of accuracy while positioning the patient is mandatory for frameless stereotactic radiotherapy (SRT), as large doses in multiple fractions can be delivered near organs at risk. The objective of this study is to propose an end-to-end quality assurance method to verify that submillimetre alignment can be achieved with stereotactic conventional linacs.

Methods: We used a TrueBeam® linear accelerator equipped with a 6DOF robotic couch. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.005DOI Listing

Tolerance and efficacy of dose escalation using IMRT combined with chemotherapy for unresectable esophageal carcinoma: Long-term results of 51 patients.

Cancer Radiother 2020 Apr 7;24(2):88-92. Epub 2020 Mar 7.

Radiation Oncology Department, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse, 1, avenue Irène Joliot-Curie, 31059 Toulouse Cedex 9, France.

Purpose: The optimal dose in esophageal cancer patients treated with definitive chemoradiation (CRT) remains debated. We herein report on the dosimetric results, treatment-related toxicities and long-term outcomes of escalated dose up to 60Gy delivered with intensity-modulated radiotherapy (IMRT).

Materials And Methods: All consecutive patients that received a definitive CRT>50Gy for an unresectable esophageal carcinoma between 2010 and 2015 were retrospectively evaluated for this study. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.006DOI Listing

The role of postoperative radiotherapy (PORT) in pulmonary large cell neuroendocrine carcinoma (PLCNEC).

Cancer Radiother 2020 Jun 7;24(3):215-221. Epub 2020 Mar 7.

Department of Medical Oncology, Second hospital of Shanxi Medical University, 030001 Taiyuan, Shanxi, China.

Purpose: To assess the long-term survivals and related prognostic indicators of patients with pulmonary large cell neuroendocrine carcinoma (PLCNEC), and determine the prognostic value of post-operative radiotherapy in PLCNEC.

Materials And Methods: Patients diagnosed with PLCNEC between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were included in our study. Cox proportional hazard model was used to evaluate the factors related to overall survival (OS). Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.004DOI Listing

[Radiotherapy for ovarian carcinoma management: Literature review].

Cancer Radiother 2020 Apr 6;24(2):159-165. Epub 2020 Mar 6.

Centre de radiothérapie Charcot, ORLAM, Sainte Foy Lès Lyon, France; Centre de radiothérapie Mermoz, ORLAM, Lyon, France; Centre de radiothérapie et Oncologie, ORLAM, Macon, France; Centre de radiothérapie Bayard, ORLAM, Villeurbanne, France.

Ovarian cancer is the fifth most common cancer in women in France with 4714 new cases in 2017. More than 70% of patients whose disease is initially locally advanced will present locoregional or distant recurrence. Therapeutic options in this situation are not consensual. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.10.006DOI Listing

[Biologic effects of high doses per fraction].

Cancer Radiother 2020 Apr 20;24(2):153-158. Epub 2020 Feb 20.

Service d'oncologie-radiothérapie, hôpitaux universitaires Henri-Mondor, CHU de Henri-Mondor, université Paris-Est-Créteil, AP-HP, 51, avenue Mal-De-Lattre-de-Tassigny, 94000 Créteil, France; Inserm, unité 955 équipe 07, Créteil, France.

The radiobiological concepts described for conventional doses per fraction (1.8 to 2Gy) seem difficult to translate to high doses per fraction radiobiology. In fact, specific mechanisms are involved during high dose per fraction irradiation, involving vascular microenvironment damage and anti tumor immune response. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.06.017DOI Listing