1,522 results match your criteria Cancer Metastasis Rev.[Journal]


Current therapy of advanced colorectal cancer according to RAS/RAF mutational status.

Cancer Metastasis Rev 2020 Jul 9. Epub 2020 Jul 9.

Department of Oncology, South-Pest Hospital Centre - National Institute for Infectology and Haematology, Budapest, Hungary.

Colorectal cancer is a clinically and molecularly heterogeneous disease. Currently, extended RAS and BRAF mutation testing is obligatory in routine clinical practice before starting any treatment in the metastatic setting. Treatment decision making also includes assessment of the clinical condition of the patient, definition of the treatment goal, and consideration of the primary tumor site. Read More

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http://dx.doi.org/10.1007/s10555-020-09913-7DOI Listing

The effects of mutant Ras proteins on the cell signalome.

Cancer Metastasis Rev 2020 Jul 9. Epub 2020 Jul 9.

Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.

The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras is a key molecule that controls several tumorigenesis-related processes, and mutations in RAS genes often lead to unbiased intensification of signaling networks that fuel cancer progression. In this article, we review recent studies that describe mutant Ras-regulated signaling routes and their cross-talk. Read More

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http://dx.doi.org/10.1007/s10555-020-09912-8DOI Listing

Role of linoleic acid-derived oxylipins in cancer.

Cancer Metastasis Rev 2020 Jul 4. Epub 2020 Jul 4.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Building 101, Room A214, Research Triangle Park, Durham, NC, 27709, USA.

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http://dx.doi.org/10.1007/s10555-020-09904-8DOI Listing

The role of fibroblast activation protein in health and malignancy.

Cancer Metastasis Rev 2020 Jun 29. Epub 2020 Jun 29.

Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3870 Reservoir Road NW, Washington, DC, 20057, USA.

Fibroblast activation protein-α (FAP) is a type-II transmembrane serine protease expressed almost exclusively to pathological conditions including fibrosis, arthritis, and cancer. Across most cancer types, elevated FAP is associated with worse clinical outcomes. Despite the clear association between FAP and disease severity, the biological reasons underlying these clinical observations remain unclear. Read More

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http://dx.doi.org/10.1007/s10555-020-09909-3DOI Listing

Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer.

Cancer Metastasis Rev 2020 Jun 27. Epub 2020 Jun 27.

Division of Cancer Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Chemotherapy is one of the important and effective options for cancer treatment in the past decades. Although the response rate of initial chemotherapy is considerably high in certain types of cancers, such as ovarian cancer and lung cancer, the patients frequently suffer from chemoresistance and recurrence of disease. Recent genome-wide studies have shown that the large number of long non-coding RNAs (lncRNAs) are transcribed from the human genome and involved in many biological processes including carcinogenesis. Read More

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http://dx.doi.org/10.1007/s10555-020-09910-wDOI Listing

Biography-Ivan Robert Nabi.

Authors:
Ivan Robert Nabi

Cancer Metastasis Rev 2020 Jun;39(2):333

Life Sciences Institute, Department of Cellular and Physiological Sciences, School of Biomedical Engineering, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1007/s10555-020-09893-8DOI Listing

Regulation of breast cancer metastasis signaling by miRNAs.

Cancer Metastasis Rev 2020 Jun 23. Epub 2020 Jun 23.

Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, 40292, USA.

Despite the decline in death rate from breast cancer and recent advances in targeted therapies and combinations for the treatment of metastatic disease, metastatic breast cancer remains the second leading cause of cancer-associated death in U.S. women. Read More

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http://dx.doi.org/10.1007/s10555-020-09905-7DOI Listing

Multiple roles of HOX proteins in Metastasis: Let me count the ways.

Cancer Metastasis Rev 2020 Jun 22. Epub 2020 Jun 22.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, 1650 Orleans Street, CRB1-143, Baltimore, MD, 21231, USA.

Knowledge of the role of HOX proteins in cancer has been steadily accumulating in the last 25 years. They are encoded by 39 HOX genes arranged in 4 distinct clusters, and have unique and redundant function in all types of cancers. Many HOX genes behave as oncogenic transcriptional factors regulating multiple pathways that are critical to malignant progression in a variety of tumors. Read More

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http://dx.doi.org/10.1007/s10555-020-09908-4DOI Listing

Current therapy of KRAS-mutant lung cancer.

Cancer Metastasis Rev 2020 Jun 16. Epub 2020 Jun 16.

Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Rath Gyorgy u. 7-9, Budapest, 1122, Hungary.

KRAS mutations are the most frequent gain-of-function alterations in patients with lung adenocarcinoma (LADC) in the Western world. Although they have been identified decades ago, prior efforts to target KRAS signaling with single-agent therapeutic approaches such as farnesyl transferase inhibitors, prenylation inhibition, impairment of KRAS downstream signaling, and synthetic lethality screens have been unsuccessful. Moreover, the role of KRAS oncogene in LADC is still not fully understood, and its prognostic and predictive impact with regards to the standard of care therapy remains controversial. Read More

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http://dx.doi.org/10.1007/s10555-020-09903-9DOI Listing

K-Ras prenylation as a potential anticancer target.

Cancer Metastasis Rev 2020 Jun 10. Epub 2020 Jun 10.

Department of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.

KRAS is one of the most commonly mutated oncogene and a negative predictive factor for a number of targeted therapies. Therefore, the development of targeting strategies against mutant KRAS is urgently needed. One potential strategy involves disruption of K-Ras membrane localization, which is necessary for its proper function. Read More

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http://dx.doi.org/10.1007/s10555-020-09902-wDOI Listing

Lung cancer identification: a review on detection and classification.

Cancer Metastasis Rev 2020 Jun 9. Epub 2020 Jun 9.

Computer Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, India.

Lung cancer is one of the most common diseases among humans and one of the major causes of growing mortality. Medical experts believe that diagnosing lung cancer in the early phase can reduce death with the illustration of lung nodule through computed tomography (CT) screening. Examining the vast amount of CT images can reduce the risk. Read More

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http://dx.doi.org/10.1007/s10555-020-09901-xDOI Listing

Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression.

Cancer Metastasis Rev 2020 Jun;39(2):485-503

Mechanoadaptation and Caveolae Biology Lab, Cell and Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Read More

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http://dx.doi.org/10.1007/s10555-020-09900-yDOI Listing

Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

Cancer Metastasis Rev 2020 Jun 7. Epub 2020 Jun 7.

Institute for Immunology, LMU Munich, Grosshadernerstr. 9, 82152 Planegg, Martinsried, Germany.

EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas and their metastases, EpCAM serves as a prognostic marker, a therapeutic target, and an anchor molecule on circulating and disseminated tumor cells (CTCs/DTCs), which are considered the major source for metastatic cancer cells. Today, EpCAM is reckoned as a multi-functional transmembrane protein involved in the regulation of cell adhesion, proliferation, migration, stemness, and epithelial-to-mesenchymal transition (EMT) of carcinoma cells. Read More

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http://dx.doi.org/10.1007/s10555-020-09898-3DOI Listing

Brain tumor vessels-a barrier for drug delivery.

Cancer Metastasis Rev 2020 Jun 2. Epub 2020 Jun 2.

Dept of Health Technology, Technical University of Denmark, 2800, Kgs Lyngby, Denmark.

Cancer treatment remains a challenge due to a high level of intra- and intertumoral heterogeneity and the rapid development of chemoresistance. In the brain, this is further hampered by the blood-brain barrier that reduces passive diffusion of drugs to a minimum. Tumors grow invasively and form new blood vessels, also in brain tissue where remodeling of pre-existing vasculature is substantial. Read More

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http://dx.doi.org/10.1007/s10555-020-09877-8DOI Listing

Unraveling mucin domains in cancer and metastasis: when protectors become predators.

Cancer Metastasis Rev 2020 Jun 2. Epub 2020 Jun 2.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

A dynamic mucosal layer shields the epithelial cells lining the body cavities and is made up of high molecular weight, heavily glycosylated, multidomain proteins called mucins. Mucins, broadly grouped into transmembrane and secreted mucins, are the first responders to any mechanical or chemical insult to the epithelia and help maintain tissue homeostasis. However, their intrinsic properties to protect and repair the epithelia are exploited during oncogenic processes, where mucins are metamorphosed to aid the tumor cells in their malignant journey. Read More

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http://dx.doi.org/10.1007/s10555-020-09896-5DOI Listing
June 2020
7.234 Impact Factor

Membrane tension buffering by caveolae: a role in cancer?

Cancer Metastasis Rev 2020 Jun;39(2):505-517

UMR3666, INSERM U1143, Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Institut Curie - Centre de Recherche, PSL Research University, CNRS, 75005, Paris, France.

Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-1 and cavins, which are abundantly present at the plasma membrane of vertebrate cells. Since their discovery more than 60 years ago, the function of caveolae has been mired in controversy. The last decade has seen the characterization of new caveolae components and regulators together with the discovery of additional cellular functions that have shed new light on these enigmatic structures. Read More

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http://dx.doi.org/10.1007/s10555-020-09899-2DOI Listing

Endothelial caveolin and its scaffolding domain in cancer.

Cancer Metastasis Rev 2020 Jun;39(2):471-483

Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia (UBC), 2176 Health Sciences mall, room 217, Vancouver, BC, V6T 1Z3, Canada.

Since the initial reports implicating caveolin-1 (CAV1) in neoplasia, the scientific community has made tremendous strides towards understanding how CAV1-dependent signaling and caveolae assembly modulate solid tumor growth. Once a solid neoplastic tumor reaches a certain size, it will increasingly rely on its stroma to meet the metabolic demands of the rapidly proliferating cancer cells, a limitation typically but not exclusively addressed via the formation of new blood vessels. Landmark studies using xenograft tumor models have highlighted the importance of stromal CAV1 during neoplastic blood vessel growth from preexisting vasculature, a process called angiogenesis, and helped identify endothelium-specific signaling events regulated by CAV1, such as vascular endothelial growth factor (VEGF) receptors as well as the endothelial nitric oxide (NO) synthase (eNOS) systems. Read More

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http://dx.doi.org/10.1007/s10555-020-09895-6DOI Listing

Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer.

Cancer Metastasis Rev 2020 Jun;39(2):435-453

Laboratory of Cellular Communication, Center for studies on Exercise, Metabolism and Cancer (CEMC), Programa de Biología Celular y Molecular, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular organelles and compartments. The contributions of these intracellular pools to CAV1 function are generally less well understood, and this is also the case in the context of cancer. Read More

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http://dx.doi.org/10.1007/s10555-020-09890-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311495PMC

Cutting the edge between cancerogenesis and organogenesis of the pancreatic endocrine lineage allocation-comprehensive review of the genes Synaptotagmin 13 and 533041C22 Rik in epithelial-to-mesenchymal transition.

Cancer Metastasis Rev 2020 May 24. Epub 2020 May 24.

TUM München, Arcisstraße 21, 80333, Munich, Germany.

In the past years, a multitude of studies has been published in the field of pancreatic organogenesis to interrogate the critical regulators of endocrine lineage segregation. Preliminary, transcription factors are guiding the transcriptional hierarchy of the endocrine specified cells, underpinning the importance of open chromatin formation. Signaling pathways either inhibit or accelerate the transcriptional landscape of pancreatic organogenesis. Read More

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http://dx.doi.org/10.1007/s10555-020-09897-4DOI Listing

Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis.

Cancer Metastasis Rev 2020 May 23. Epub 2020 May 23.

Luis Costa Lab, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028, Lisboa, Portugal.

Progression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidence suggests that it has an important role in cancer progression and metastasis. Read More

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http://dx.doi.org/10.1007/s10555-020-09888-5DOI Listing

Tyrosine phosphorylation of tumor cell caveolin-1: impact on cancer progression.

Cancer Metastasis Rev 2020 Jun;39(2):455-469

Life Sciences Institute, Department of Cellular and Physiological Sciences, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.

Caveolin-1 (CAV1) has long been implicated in cancer progression, and while widely accepted as an oncogenic protein, CAV1 also has tumor suppressor activity. CAV1 was first identified in an early study as the primary substrate of Src kinase, a potent oncoprotein, where its phosphorylation correlated with cellular transformation. Indeed, CAV1 phosphorylation on tyrosine-14 (Y14; pCAV1) has been associated with several cancer-associated processes such as focal adhesion dynamics, tumor cell migration and invasion, growth suppression, cancer cell metabolism, and mechanical and oxidative stress. Read More

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http://dx.doi.org/10.1007/s10555-020-09892-9DOI Listing

The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment.

Cancer Metastasis Rev 2020 May 20. Epub 2020 May 20.

Centro de Estudios Biomédicos, Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimonides, Hidalgo 775, Buenos Aires, Argentina.

Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its overexpression has been implicated in the progression of several tumor types by promoting cell motility, invasion, EMT, and metastasis. Recent evidences have revealed a novel role of Wnt5a in the phosphorylation of the NF-κB subunit p65 and the activation of the NF-κB pathway in cancer cells. In this article, we review the molecular mechanisms and mediators defining a Wnt5a/NF-κB signaling pathway and propose that the aberrant expression of Wnt5a in some tumors drives a Wnt5a/NF-κB/IL-6/STAT3 positive feedback loop that amplifies the effects of Wnt5a. Read More

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http://dx.doi.org/10.1007/s10555-020-09878-7DOI Listing

Caveolin and lipid domains-close companions in managing cellular pathways.

Cancer Metastasis Rev 2020 Jun;39(2):341-342

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/s10555-020-09891-wDOI Listing

Preface.

Authors:
Ivan Robert Nabi

Cancer Metastasis Rev 2020 Jun;39(2):335

Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1007/s10555-020-09894-7DOI Listing

MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein.

Cancer Metastasis Rev 2020 May 14. Epub 2020 May 14.

Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, 23298, USA.

Tumor metastasis comprises a series of coordinated events that culminate in dissemination of cancer cells to distant sites within the body representing the greatest challenge impeding effective therapy of cancer and the leading cause of cancer-associated morbidity. Cancer cells exploit multiple genes and pathways to colonize to distant organs. These pathways are integrated and regulated at different levels by cellular- and extracellular-associated factors. Read More

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http://dx.doi.org/10.1007/s10555-020-09886-7DOI Listing

Molecular and cellular mechanisms underlying brain metastasis of breast cancer.

Cancer Metastasis Rev 2020 May 13. Epub 2020 May 13.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are at high risk for the development of brain metastases. Despite recent advances in the treatment of primary breast tumors, the prognosis of breast cancer patients with brain metastases remains poor. Read More

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http://dx.doi.org/10.1007/s10555-020-09881-yDOI Listing

Epigenetic dynamics in cancer stem cell dormancy.

Cancer Metastasis Rev 2020 May 12. Epub 2020 May 12.

Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA.

Cancer remains one of the most challenging diseases despite significant advances of early diagnosis and therapeutic treatments. Cancerous tumors are composed of various cell types including cancer stem cells capable of self-renewal, proliferation, differentiation, and invasion of distal tumor sites. Most notably, these cells can enter a dormant cellular state that is resistant to conventional therapies. Read More

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http://dx.doi.org/10.1007/s10555-020-09882-xDOI Listing

Glycosylation and raft endocytosis in cancer.

Cancer Metastasis Rev 2020 Jun;39(2):375-396

Cellular and Chemical Biology Unit, INSERM U1143, CNRS UMR3666, Institut Curie, PSL Research University, 26 rue d'Ulm, 75248, Paris Cedex 05, France.

Changes in glycosylation on proteins or lipids are one of the hallmarks of tumorigenesis. In many cases, it is still not understood how glycan information is translated into biological function. In this review, we discuss at the example of specific cancer-related glycoproteins how their endocytic uptake into eukaryotic cells is tuned by carbohydrate modifications. Read More

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http://dx.doi.org/10.1007/s10555-020-09880-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311491PMC

Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis.

Cancer Metastasis Rev 2020 May 9. Epub 2020 May 9.

Translational and Clinical Research Institute, Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, UK.

The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound transporters required to transport a diverse array of substrates over biological membranes. Physiologically, they are essential for nutrient uptake, ion transport and waste removal. However, accumulating evidence suggest that up- and/or downregulation of SLCs may play a pivotal role in the pathogenesis of human malignancy. Read More

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http://dx.doi.org/10.1007/s10555-020-09879-6DOI Listing

CDK7 inhibitors as anticancer drugs.

Cancer Metastasis Rev 2020 May 8. Epub 2020 May 8.

Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK.

Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-activating complex (CAK), which directs progression through the cell cycle via T-loop phosphorylation of cell cycle CDKs. CAK is also a component of the general transcription factor, TFIIH. CDK7-mediated phosphorylation of RNA polymerase II (Pol II) at active gene promoters permits transcription. Read More

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http://dx.doi.org/10.1007/s10555-020-09885-8DOI Listing

Wnts and the hallmarks of cancer.

Cancer Metastasis Rev 2020 May 8. Epub 2020 May 8.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in cancers have been extensively investigated. Activation of this evolutionarily conserved pathway promotes cancer development via diverse mechanisms. Cancer is a complex disease and one outstanding conceptual framework for understanding its biology is the "Hallmarks of Cancer". Read More

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http://dx.doi.org/10.1007/s10555-020-09887-6DOI Listing

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

Cancer Metastasis Rev 2020 06;39(2):337-340

Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California, Davis, Davis, CA, 95616, USA.

Severe coronavirus disease (COVID-19) is characterized by pulmonary hyper-inflammation and potentially life-threatening "cytokine storms". Controlling the local and systemic inflammatory response in COVID-19 may be as important as anti-viral therapies. Endogenous lipid autacoid mediators, referred to as eicosanoids, play a critical role in the induction of inflammation and pro-inflammatory cytokine production. Read More

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http://dx.doi.org/10.1007/s10555-020-09889-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207990PMC

FOXO transcription factor family in cancer and metastasis.

Cancer Metastasis Rev 2020 May 5. Epub 2020 May 5.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting development, metabolism, stem cell maintenance and longevity. They have also been increasingly recognised as tumour suppressors through their ability to regulate genes essential for cell proliferation, cell death, senescence, angiogenesis, cell migration and metastasis. Mechanistically, FOXO proteins serve as key connection points to allow diverse proliferative, nutrient and stress signals to converge and integrate with distinct gene networks to control cell fate, metabolism and cancer development. Read More

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http://dx.doi.org/10.1007/s10555-020-09883-wDOI Listing

Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy.

Cancer Metastasis Rev 2020 May 4. Epub 2020 May 4.

Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

Response evaluation for cancer treatment consists primarily of clinical and radiological assessments. In addition, a limited number of serum biomarkers that assess treatment response are available for a small subset of malignancies. Through recent technological innovations, new methods for measuring tumor burden and treatment response are becoming available. Read More

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http://dx.doi.org/10.1007/s10555-020-09876-9DOI Listing
May 2020
7.234 Impact Factor

RNA-biology ruling cancer progression? Focus on 3'UTRs and splicing.

Cancer Metastasis Rev 2020 May 2. Epub 2020 May 2.

Department of Biological Sciences and Cancer Systems Biology Laboratory, Middle East Technical University (METU, ODTU), Dumlupinar Blv No: 1, Universiteler Mah, 06800, Ankara, Turkey.

The protein-coding regions of mRNAs have the information to make proteins and hence have been at the center of attention for understanding altered protein functions in disease states, including cancer. Indeed, the discovery of genomic alterations and driver mutations that change protein levels and/or activity has been pivotal in our understanding of cancer biology. However, to better understand complex molecular mechanisms that are deregulated in cancers, we also need to look at non-coding parts of mRNAs, including 3'UTRs (untranslated regions), which control mRNA stability, localization, and translation efficiency. Read More

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http://dx.doi.org/10.1007/s10555-020-09884-9DOI Listing

Caveola-forming proteins and prostate cancer.

Cancer Metastasis Rev 2020 Jun;39(2):415-433

School of Pharmacy, University of Queensland , 20 Cornwall Street, Woolloongabba, QLD, 4102, Australia.

Caveolae are specialised and dynamic plasma membrane subdomains, involved in many cellular functions including endocytosis, signal transduction, mechanosensing and lipid storage, trafficking, and metabolism. Two protein families are indispensable for caveola formation and function, namely caveolins and cavins. Mutations of genes encoding these caveolar proteins cause serious pathological conditions such as cardiomyopathies, skeletal muscle diseases, and lipodystrophies. Read More

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http://dx.doi.org/10.1007/s10555-020-09874-xDOI Listing

The role of lipid species in membranes and cancer-related changes.

Cancer Metastasis Rev 2020 Jun;39(2):343-360

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Ullernchausséen 70, 0379, Oslo, Norway.

Several studies have demonstrated interactions between the two leaflets in membrane bilayers and the importance of specific lipid species for such interaction and membrane function. We here discuss these investigations with a focus on the sphingolipid and cholesterol-rich lipid membrane domains called lipid rafts, including the small flask-shaped invaginations called caveolae, and the importance of such membrane structures in cell biology and cancer. We discuss the possible interactions between the very long-chain sphingolipids in the outer leaflet of the plasma membrane and the phosphatidylserine species PS 18:0/18:1 in the inner leaflet and the importance of cholesterol for such interactions. Read More

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http://dx.doi.org/10.1007/s10555-020-09872-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311489PMC

Flotillin membrane domains in cancer.

Cancer Metastasis Rev 2020 Jun;39(2):361-374

CRBM, University of Montpellier, CNRS, Montpellier, France.

Flotillins 1 and 2 are two ubiquitous, highly conserved homologous proteins that assemble to form heterotetramers at the cytoplasmic face of the plasma membrane in cholesterol- and sphingolipid-enriched domains. Flotillin heterotetramers can assemble into large oligomers to form molecular scaffolds that regulate the clustering of at the plasma membrane and activity of several receptors. Moreover, flotillins are upregulated in many invasive carcinomas and also in sarcoma, and this is associated with poor prognosis and metastasis formation. Read More

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http://dx.doi.org/10.1007/s10555-020-09873-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311376PMC

Caveolin-1, a master regulator of cellular senescence.

Cancer Metastasis Rev 2020 Jun;39(2):397-414

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.

Cellular senescence is a feature of most somatic cells. It is characterized by an irreversible cell cycle arrest and by the ability to secrete a plethora of mediators of inflammation and growth factors, which can alter the senescent cell's microenvironment. Senescent cells accumulate in tissues over time and contribute to both aging and the development of age-associated diseases. Read More

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http://dx.doi.org/10.1007/s10555-020-09875-wDOI Listing

Emerging links between endosomal pH and cancer.

Cancer Metastasis Rev 2020 Jun;39(2):519-534

Department of Physiology, The Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD, 21205, USA.

Extracellular acidification is a well-known driver of tumorigenesis that has been extensively studied. In contrast, the role of endosomal pH is novel and relatively unexplored. There is emerging evidence from a growing number of studies showing that the pH of endosomal compartments controls proliferation, migration, stemness, and sensitivity to chemoradiation therapy in a variety of tumors. Read More

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http://dx.doi.org/10.1007/s10555-020-09870-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316587PMC

BRMS1: a multifunctional signaling molecule in metastasis.

Cancer Metastasis Rev 2020 Mar 30. Epub 2020 Mar 30.

Department of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.

Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti-metastasis genes. The metastasis suppressor, breast cancer metastasis suppressor 1 (BRMS1), has been positively correlated with patient outcomes, but molecular functions are still being characterized. Read More

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http://dx.doi.org/10.1007/s10555-020-09871-0DOI Listing

Professor Samuel C. Brooks, Jr., Ph.D. (1928-2019).

Cancer Metastasis Rev 2020 Mar;39(1):331-332

Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI, USA.

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http://dx.doi.org/10.1007/s10555-020-09861-2DOI Listing

How progressive cancer endangers the heart: an intriguing and underestimated problem.

Cancer Metastasis Rev 2020 Jun;39(2):535-552

Department of Medical Oncology, Local Health Unit 3 Serenissima, Mirano Hospital, Mirano, Venice, Italy.

Since it came into being as a discipline, cardio-oncology has focused on the prevention and treatment of cardiotoxicity induced by antitumor chemotherapy and radiotherapy. Over time, it has been proved that even more detrimental is the direct effect generated by cancer cells that release pro-cachectic factors in the bloodstream. Secreted molecules target different organs at a distance, including the heart. Read More

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http://dx.doi.org/10.1007/s10555-020-09869-8DOI Listing

KISS1 in metastatic cancer research and treatment: potential and paradoxes.

Cancer Metastasis Rev 2020 Mar 9. Epub 2020 Mar 9.

Department of Cancer Biology, Kansas University Medical Center, 3901 Rainbow Blvd. - MS1071, Kansas City, KS, 66160, USA.

The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. Read More

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http://dx.doi.org/10.1007/s10555-020-09868-9DOI Listing

Pediatric medulloblastoma in the molecular era: what are the surgical implications?

Cancer Metastasis Rev 2020 Mar;39(1):235-243

Division of Neurosurgery, Department of Surgery, Hamilton General Hospital, McMaster University, 237 Barton Street East, Hamilton, Ontario, L8L 2X2, Canada.

Pediatric brain tumors are the leading cause of childhood cancer mortality with medulloblastoma (MB) representing the most frequent malignant tumor. Although standardization of therapy resulted in a 2-fold reduction in mortality in patients with MB by 2002, it became clear that further improvements in clinical outcome would require a deeper understanding of the biology of MB. Employing the four main molecular MB subgroups (Wnt, Shh, Group 3 and Group 4), a restratification into clinicogenomic risk categories quantified an unacceptable survival for the high-risk group, urging researchers to focus their efforts towards acquiring a greater biological understanding of these children. Read More

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http://dx.doi.org/10.1007/s10555-020-09865-yDOI Listing

New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence.

Cancer Metastasis Rev 2020 Mar;39(1):303-320

Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.

Melatonin is an indole produced by the pineal gland at night under normal light or dark conditions, and its levels, which are higher in children than in adults, begin to decrease prior to the onset of puberty and continue to decline thereafter. Apart from circadian regulatory actions, melatonin has significant apoptotic, angiogenic, oncostatic, and antiproliferative effects on various cancer cells. Particularly, the ability of melatonin to inhibit skeletomuscular sarcoma, which most commonly affects children, teenagers, and young adults, is substantial. Read More

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http://dx.doi.org/10.1007/s10555-020-09845-2DOI Listing

Correction to: Neurological complications of pediatric cancer.

Cancer Metastasis Rev 2020 Mar;39(1):25

Department of Neurology, Johns Hopkins Hospital, 200 N Wolfe St Suite 2158, Baltimore, MD, 21287, USA.

The authors have noticed a typographical error in the published article. Read More

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http://dx.doi.org/10.1007/s10555-020-09867-wDOI Listing

Preface.

Cancer Metastasis Rev 2020 Mar;39(1):1-2

Center for Vascular Biology Research, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s10555-020-09862-1DOI Listing

Cardiovascular diseases in survivors of childhood cancer.

Cancer Metastasis Rev 2020 Mar;39(1):55-68

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.

Over the past few decades, the diagnosis and management of children with various malignancies have improved tremendously. As a result, there are an increasing number of children who are long-term cancer survivors. With improved survival, however, has come an increased risk of treatment-related cardiovascular complications that can appear decades after treatment. Read More

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http://dx.doi.org/10.1007/s10555-020-09859-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123498PMC
March 2020
7.234 Impact Factor

Integration of EMT and cellular survival instincts in reprogramming of programmed cell death to anastasis.

Cancer Metastasis Rev 2020 Jun;39(2):553-566

Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.

Apoptosis is a tightly controlled, coordinated cellular event responsible for inducing programmed cell death to rid the body of defective or unfit cells. Inhibition of apoptosis is, therefore, an essential process for cancer cells to harness. Genomic variants in apoptotic-controlling genes are highly prevalent in cancer and have been identified to induce pro-proliferation and pro-survival pathways, rendering cancer cells resistant to apoptosis. Read More

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http://dx.doi.org/10.1007/s10555-020-09866-xDOI Listing
June 2020
7.234 Impact Factor