3,063 results match your criteria Cancer Med[Journal]


Physical activity during and after breast cancer therapy and associations of baseline physical activity with changes in cardiac function by echocardiogram.

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Observational studies suggest that regular physical activity may reduce cardiovascular morbidity and cancer recurrence in survivors of breast cancer. The association between physical activity and cardiac function with breast cancer therapy is unknown.

Methods: Self-reported physical activity was assessed using the Godin Leisure-Time Exercise Questionnaire at repeated intervals in a longitudinal cohort study of 603 breast cancer participants treated with doxorubicin and/or trastuzumab. Read More

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http://dx.doi.org/10.1002/cam4.3277DOI Listing

Population bias in somatic measurement of microsatellite instability status.

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Caris Life Sciences, Phoenix, AZ, USA.

Microsatellite instability (MSI) is a key secondary effect of a defective DNA mismatch repair mechanism resulting in incorrectly replicated microsatellites in many malignant tumors. Historically, MSI detection has been performed by fragment analysis (FA) on a panel of representative genomic markers. More recently, using next-generation sequencing (NGS) to analyze thousands of microsatellites has been shown to improve the robustness and sensitivity of MSI detection. Read More

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http://dx.doi.org/10.1002/cam4.3294DOI Listing

Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix.

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Molecular Cell Biology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Aims: The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new squamocolumnar junctions are formed, and premalignant lesions originate. SOX17 and SOX2 show mutually exclusive expression patterns in the normal uterine cervix, with SOX2 being exclusively found in squamous epithelium, while SOX17 is detected in endocervical columnar cells and reserve cells. Read More

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http://dx.doi.org/10.1002/cam4.3201DOI Listing

Validation of the Dutch version of the Edmonton Symptom Assessment System.

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Center of Expertise in Palliative Care, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University Utrecht, The Netherlands.

Background: The Utrecht Symptom Diary (USD) is a Dutch and adapted version of the Edmonton Symptom Assessment System, a patient-reported outcome measurement (PROM) tool to asses and monitor symptoms in cancer patients. This study analyses the validity and responsiveness of the USD and the cutoff points to determine the clinical significance of a symptom score.

Methods: Observational longitudinal cohort study including adult in- and outpatients treated in an academic hospital in the Netherlands who completed at least one USD as part of routine care (2012-2019). Read More

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http://dx.doi.org/10.1002/cam4.3253DOI Listing

Body mass index trajectories and prostate cancer risk: Results from the EPICAP study.

Cancer Med 2020 Jul 8. Epub 2020 Jul 8.

Université Paris-Saclay, UVSQ, Inserm, CESP, Villejuif, France.

Elevated body mass index (BMI) has been inconsistently associated with prostate cancer occurrence but it has been suggested that life course adulthood obesity may be associated with an increased risk of prostate cancer. However, few studies have investigated lifetime BMI and prostate cancer risk. We analyzed life course BMI trajectories on prostate cancer risk based on data from the Epidemiological study of Prostate Cancer (EPICAP). Read More

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http://dx.doi.org/10.1002/cam4.3241DOI Listing

DNA aneuploidy with image cytometry for detecting dysplasia and carcinoma in oral potentially malignant disorders: A prospective diagnostic study.

Cancer Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Background: Current evidence on diagnostic value of aneuploidy with DNA image cytometry (ICM) using brushings for oral potentially malignant disorders (OPMD) is limited by sample size and inconsistent classification criteria of aneuploidy. This study aimed to explore the optimal cut-off values of DNA content and evaluate the diagnostic accuracy of DNA-ICM for detecting dysplasia and/or carcinoma in OPMD.

Materials And Methods: A total of 401 consecutive patients with OPMD were enrolled in this prospective diagnostic study. Read More

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http://dx.doi.org/10.1002/cam4.3293DOI Listing

Role of the oral microbiota in cancer evolution and progression.

Cancer Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Stomatology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Bacteria identified in the oral cavity are highly complicated. They include approximately 1000 species with a diverse variety of commensal microbes that play crucial roles in the health status of individuals. Epidemiological studies related to molecular pathology have revealed that there is a close relationship between oral microbiota and tumor occurrence. Read More

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http://dx.doi.org/10.1002/cam4.3206DOI Listing

Cell-free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experience.

Cancer Med 2020 Jul 7. Epub 2020 Jul 7.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: The enucleation rate for retinoblastoma has dropped from over 95% to under 10% in the past 10 years as a result of improvements in therapy. This reduces access to tumor tissue for molecular profiling, especially in unilateral retinoblastoma, and hinders the confirmation of somatic RB1 mutations necessary for genetic counseling. Plasma cell-free DNA (cfDNA) has provided a platform for noninvasive molecular profiling in cancer, but its applicability in low tumor burden retinoblastoma has not been shown. Read More

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http://dx.doi.org/10.1002/cam4.3144DOI Listing

Efficacy and safety of two pegfilgrastim biosimilars: Tripegfilgrastim and pegteograstim.

Cancer Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.

Our aim was to compare the efficacy and safety of two recently developed biosimilars of pegfilgrastim, a pegylated form of the recombinant human granulocyte-colony stimulating factor (G-CSF) analog filgrastim with those of the reference pegfilgrastim. We retrospectively analyzed data from patients diagnosed with diffuse large B-cell lymphoma (DLBCL) who were treated with first-line R-CHOP chemotherapy and received pegylated G-CSF for primary prophylaxis. The following pegylated G-CSFs were analyzed in this study: reference pegfilgrastim (Neulasta ) and two of its biosimilars (tripegfilgrastim; Dulastin and pegteograstim; Neulapeg ). Read More

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http://dx.doi.org/10.1002/cam4.3261DOI Listing

Comprehensive analysis of copy number variance and sensitivity to common targeted therapy in clear cell renal cell carcinoma: In silico analysis with in vitro validation.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.

Background: Chromosomal rearrangements are common in clear cell renal cell carcinoma (ccRCC) and their roles in mediating sensitivity to tyrosine kinase inhibitors (TKIs) and mTOR inhibitors (mTORi) remain elusive.

Methods: We developed an in silico strategy by screening copy number variance (CNV) that was potentially related to TKI or mTORi sensitivity in ccRCC by reproducing the TCGA and GDSC datasets. Candidate genes should be both significantly prognostic and related to drug sensitivity or resistance, and were then validated in vitro. Read More

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http://dx.doi.org/10.1002/cam4.3281DOI Listing

The impact of bone marrow fibrosis and JAK2 expression on clinical outcomes in patients with newly diagnosed multiple myeloma treated with immunomodulatory agents and/or proteasome inhibitors.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.

We determined the impact of bone marrow fibrosis (BMF) on the clinical outcomes of newly diagnosed multiple myeloma (NDMM) patients in the current era of myeloma therapy. A total of 393 MM patients were included in the final analysis. The median followup was 83 months (range: 3. Read More

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http://dx.doi.org/10.1002/cam4.3265DOI Listing

Associations of multimorbidity and patient-reported experiences of care with conservative management among elderly patients with localized prostate cancer.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

West Virginia University School of Pharmacy, Pharmaceutical Systems & Policy, Morgantown, WV, USA.

Background: Many elderly localized prostate cancer patients could benefit from conservative management (CM). This retrospective cohort study examined the associations of patient-reported access to care and multimorbidity on CM use patterns among Medicare Fee-for-Service (FFS) beneficiaries with localized prostate cancer.

Methods: We used linked Surveillance, Epidemiology, and End Results cancer Registry, Medicare Claims, and the Medicare Consumer Assessment of Healthcare Providers and Systems (MCAHPS) survey files. Read More

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http://dx.doi.org/10.1002/cam4.3274DOI Listing

Diagnostic performance of various liquid biopsy methods in detecting colorectal cancer: A meta-analysis.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Liquid biopsy is a promising method in detecting colorectal cancer (CRC). However, previous meta-analyses only focused on the diagnostic performance of cell-free DNA (cfDNA). Therefore, we firstly evaluated the overall performance of all liquid biopsy methods. Read More

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http://dx.doi.org/10.1002/cam4.3276DOI Listing

Effect of the surgical approach on survival outcomes in patients undergoing radical hysterectomy for cervical cancer: A real-world multicenter study of a large Chinese cohort from 2006 to 2017.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Objective: To compare survival outcomes of minimally invasive surgery (MIS) and laparotomy in early-stage cervical cancer (CC) patients.

Methods: A multicenter retrospective cohort study was conducted with International Federation of Gynecology and Obstetrics (FIGO, 2009) stage IA1 (lymphovascular invasion)-IIA1 CC patients undergoing MIS or laparotomy at four tertiary hospitals from 2006 to 2017. Propensity score matching and weighting and multivariate Cox regression analyses were performed. Read More

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http://dx.doi.org/10.1002/cam4.3287DOI Listing

Genome-wide DNA methylome analysis reveals methylation subtypes with different clinical outcomes for acute myeloid leukemia patients.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Hematology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.

Leukemia is the second common blood cancer after lymphoma, and its incidence rate has an increasing trend in recent years. Acute myeloid leukemia (AML) is one of the prevalent forms of leukemia. Although previous studies have investigated the methylation profile for AML patients, the AML methylation subtypes based on the genome-wide methylome are still unclear. Read More

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http://dx.doi.org/10.1002/cam4.3291DOI Listing

Effect of Chin-down-plus-larynx-tightening maneuver on swallowing function after minimally invasive esophagectomy: A randomized controlled trail.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Nursing Department, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Background: The incidence of swallowing abnormality was high after minimally invasive esophagectomy (MIE) for esophageal cancer (EC). Few reports, however, focused on interventions for dysphagia after esophagectomy.

Aim: The purpose of this research was to estimate the effect of Chin-down-plus-larynx-tightening maneuver on swallowing function for patients receiving esophagectomy. Read More

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http://dx.doi.org/10.1002/cam4.3280DOI Listing

The influence of venous tumor thrombus combined with bland thrombus on the surgical treatment and prognosis of renal cell carcinoma patients.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Peking University Third Hospital, Beijing, China.

Objective: To describe the clinical characteristics of renal cell carcinoma (RCC) with venous tumor thrombus (VTT) and bland thrombus (BT), and to evaluate the influence of BT on surgical treatment and cancer-specific survival (CSS) of RCC with VTT.

Methods: We retrospectively reviewed clinical data of 123 patients with RCC and VTT, who underwent surgical treatment in our center between February 2015 and May 2018. Patients were divided into the BT group (21 patients) and non-BT group (102 patients). Read More

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http://dx.doi.org/10.1002/cam4.3264DOI Listing

Exosome-transmitted microRNA-133b inhibited bladder cancer proliferation by upregulating dual-specificity protein phosphatase 1.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Laboratory Medicine Center, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Bladder Cancer (BC) is the ninth most common tumor in the world and one of the most common malignant tumors of the urinary system. Some studies reported that miR-133b expression is reduced in BC, but whether it plays a role in the development of BC and its mechanism is unclear. microRNAs can be packaged into exosomes to mediate communication between tumor cells, affecting their proliferation and apoptosis. Read More

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http://dx.doi.org/10.1002/cam4.3263DOI Listing

Clinical response to chemoradiotherapy in esophageal carcinoma is associated with survival and benefit of consolidation chemotherapy.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, China.

Purpose: Few studies have reported the impact of the clinical response of patients with Esophageal Carcinoma to chemoradiotherapy (CRT). Our study examines the association between clinical response and pretreatment variables, survival, patterns of failure, and benefit of consolidation chemotherapy in subjects with esophageal squamous cell carcinoma (ESCC) patients receiving CRT.

Methods: Data from ESCC patients treated at Shandong Cancer Hospital between January 2013 and December 2016 were analyzed retrospectively. Read More

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http://dx.doi.org/10.1002/cam4.3273DOI Listing

Efficacy and safety of low-dose apatinib in ovarian cancer patients with platinum-resistance or platinum-refractoriness: A single-center retrospective study.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Gynecologic Oncology, Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.

Background: This study aimed to evaluate the efficacy and safety of apatinib with a low dose of 250 mg/d in the treatment of platinum-resistant or platinum-refractory ovarian cancer patients.

Methods: Patients with platinum-resistant or platinum-refractory ovarian carcinoma treated with 250 mg/d apatinib in our institution from November 2016 to December 2017 were retrospectively reviewed. The tumor response and progression were evaluated according to the standard by incorporating the levels of CA125 and Response Evaluation Criteria in Solid Tumors 1. Read More

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http://dx.doi.org/10.1002/cam4.3282DOI Listing

Circ-SPECC1 modulates TGFβ2 and autophagy under oxidative stress by sponging miR-33a to promote hepatocellular carcinoma tumorigenesis.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Circular RNAs (circRNAs) play vital roles in the pathogenesis and development of multiple cancers, including hepatocellular carcinoma (HCC). Nevertheless, the regulatory mechanisms of circ-SPECC1 in HCC remain poorly understood. In our study, we found that circ-SPECC1 was apparently downregulated in H O -treated HCC cells. Read More

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http://dx.doi.org/10.1002/cam4.3219DOI Listing

Corrigendum.

Authors:

Cancer Med 2020 Jul 14;9(13):4876. Epub 2020 Jun 14.

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http://dx.doi.org/10.1002/cam4.3145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333838PMC

Corrigendum.

Authors:

Cancer Med 2020 Jul 18;9(13):4877. Epub 2020 Jun 18.

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http://dx.doi.org/10.1002/cam4.3234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333851PMC

Exosome-mediated delivery of miR-204-5p inhibits tumor growth and chemoresistance.

Cancer Med 2020 Jul 2. Epub 2020 Jul 2.

Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Background: Nano-sized extracellular vesicles secreted by cells play key roles in intercellular crosstalk, and appear to be an excellent biocompatible material as therapeutic cargoes in vivo. Previously, we have demonstrated that miR-204-5p is a key tumor suppressor that could inhibit tumor growth, metastasis and chemoresistance.

Methods: A HEK293T cell line stably expressing miR-204-5p (293T-miR-204) was constructed by lentivirus transduction. Read More

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http://dx.doi.org/10.1002/cam4.3248DOI Listing

Geriatric assessment domains to predict overall survival in older cancer patients: An analysis of functional status, comorbidities, and nutritional status as prognostic factors.

Cancer Med 2020 Jul 2. Epub 2020 Jul 2.

Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.

Cancer treatments for older patients must account for heterogeneity in health and functional status. Guidelines advocate the use of geriatric assessments (GAs), but comprehensive assessments are laborious and the utility of specific GA domains remains unclear. The identification of specific domains as prognostic factors may support survival predictions and treatment decisions. Read More

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http://dx.doi.org/10.1002/cam4.3205DOI Listing

A population-based study on the prognostic impact of primary tumor sidedness in patients with peritoneal metastases from colon cancer.

Cancer Med 2020 Jul 2. Epub 2020 Jul 2.

Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Primary tumor location is an established prognostic factor in patients with (metastatic) colon cancer. Colon tumors can be divided into left-sided and right-sided tumors. The aim of this study was to determine the impact of primary tumor location on treatment and overall survival (OS) in patients with peritoneal metastases (PM) from colon cancer. Read More

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http://dx.doi.org/10.1002/cam4.3243DOI Listing

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan.

Cancer Med 2020 Jul 1. Epub 2020 Jul 1.

Division of Health Services Research, National Cancer Center, Tokyo, Japan.

Background: The incidence of male breast cancer (MBC), although rare, has shown an increase. However, the current epidemiology of and practice patterns for MBC remain unclear. This study evaluated the characteristics and care patterns for MBC compared with female breast cancer (FBC) in Japan. Read More

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http://dx.doi.org/10.1002/cam4.3267DOI Listing

Phase II trial of co-administration of CD19- and CD20-targeted chimeric antigen receptor T cells for relapsed and refractory diffuse large B cell lymphoma.

Cancer Med 2020 Jul 1. Epub 2020 Jul 1.

Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Purpose: Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has demonstrated remarkable efficacy for refractory and relapsed diffuse large B cell lymphoma (R/R DLBCL). However, this therapy failed in nearly 25% patients mainly due to antigen loss. The authors performed a phase Ⅱ trial by coadministration of anti-CD19 and anti-CD20 CAR-T cells treatment for R/R DLBCL and evaluated its efficacy and toxicity. Read More

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http://dx.doi.org/10.1002/cam4.3259DOI Listing

Breast cancer survivors' risk of interval cancers and false positive results in organized mammography screening.

Cancer Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Public Health Programmes, Regional Hospital Randers, Randers, Denmark.

Background: Breast cancer survivors are increasing followed for new breast cancers / recurrences by mammography screening only. We aimed at assessing how often breast cancer survivors get a false positive or false negative result at mammography screening.

Methods: All mammography screenings performed between 2007 and 2017 in the Danish national mammography screening programme were included. Read More

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http://dx.doi.org/10.1002/cam4.3182DOI Listing

Promising survival rate but high incidence of treatment-related mortality after reduced-dose craniospinal radiotherapy and tandem high-dose chemotherapy in patients with high-risk medulloblastoma.

Cancer Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: In this study, we report the follow-up results of reduced dose of craniospinal radiotherapy (CSRT) followed by tandem high-dose chemotherapy (HDCT) in patients with high-risk medulloblastoma (MB).

Methods: Newly diagnosed high-risk MB patients (metastatic disease, postoperative residual tumor >1.5 cm , or large cell/anaplastic histology) over 3 years of age were enrolled in this study. Read More

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http://dx.doi.org/10.1002/cam4.3199DOI Listing

Multiagent therapy with pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab ("Pom-PAD-Dara") in relapsed/refractory multiple myeloma.

Cancer Med 2020 Jul 1. Epub 2020 Jul 1.

Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.

Background: Even in the era of novel immunotherapies for multiple myeloma (MM), treatment of late-stage relapsed/refractory (RR) patients remains challenging. The aim of our study was to analyze the efficacy and safety of the five-drug combination pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab ("Pom-PAD-Dara") in RRMM.

Methods: We retrospectively analyzed data of 56 patients with RRMM who received Pom-PAD-Dara between September 2016 and May 2019. Read More

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http://dx.doi.org/10.1002/cam4.3209DOI Listing

High mutation burden of circulating cell-free DNA in early-stage breast cancer patients is associated with a poor relapse-free survival.

Cancer Med 2020 Jun 29. Epub 2020 Jun 29.

Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.

Background: High tumor mutation burden is shown to be associated with a poor clinical outcome. As the tumor-derived fraction of circulating cell-free DNA (cfDNA) is shown to reflect the genetic spectrum of the tumor, we examined whether the mutation burden of cfDNA could be used to predict the clinical outcomes of early-stage breast cancer (BC) patients.

Methods: We selected a set of 79 Finnish early-stage BC cases with a good prognosis based on traditional prognostic parameters but some of which still developed relapsed disease during follow-up. Read More

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http://dx.doi.org/10.1002/cam4.3258DOI Listing

Quantitative ultrasound radiomics in predicting response to neoadjuvant chemotherapy in patients with locally advanced breast cancer: Results from multi-institutional study.

Cancer Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: This study was conducted in order to develop a model for predicting response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC) using pretreatment quantitative ultrasound (QUS) radiomics.

Methods: This was a multicenter study involving four sites across North America, and appropriate approval was obtained from the individual ethics committees. Eighty-two patients with LABC were included for final analysis. Read More

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http://dx.doi.org/10.1002/cam4.3255DOI Listing

Clinical and cytopathological characteristics of HTLV-1 hodgkin lymphoma.

Cancer Med 2020 Jun 28. Epub 2020 Jun 28.

Division of Diagnostic Pathology, Faculty of Medicine, Fukuoka University Hospital, Fukuoka, Japan.

Background: Human T-lymphotropic virus-1 (HTLV-1) Hodgkin lymphoma (HL) is difficult to differentiate from adult T-cell leukemia/lymphoma (ATLL) with HL-like histology (HL-like ATLL).

Methods: Cytological and immunohistological features, HTLV-1 proviral DNA integration, and rearrangements of the T-cell receptor (TCR) Cβ1 gene were examined in 11 HTLV-1 patients with HL-like disease.

Results: Six patients were classified as HTLV-1 HL and five as HL-like ATLL in accordance with genetic findings of HTLV-1 proviral DNA integration and rearrangements of the TCR Cβ1 gene. Read More

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http://dx.doi.org/10.1002/cam4.3139DOI Listing

Assessment of somatic mutations in urine and plasma of Wilms tumor patients.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Laboratory of Genomics and Molecular Biology, International Research Center/CIPE, A. C. Camargo Cancer Center, São Paulo, Brazil.

Tumor DNA has been detected in body fluids of cancer patients. Somatic tumor mutations are being used as biomarkers in body fluids to monitor chemotherapy response as a minimally invasive tool. In this study, we evaluated the potential of tracking somatic mutations in free DNA of plasma and urine collected from Wilms tumor (WT) patients for monitoring treatment response. Read More

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http://dx.doi.org/10.1002/cam4.3236DOI Listing

Development and validation of an immune-related prognostic signature in lung adenocarcinoma.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China.

Background: Lung adenocarcinomas (LUAD) is the most common histological subtype of lung cancers. Tumor immune microenvironment (TIME) is involved in tumorigeneses, progressions, and metastases. This study is aimed to develop a robust immune-related signature of LUAD. Read More

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http://dx.doi.org/10.1002/cam4.3240DOI Listing

External validation of life expectancy prognostic models in patients evaluated for palliative radiotherapy at the end-of-life.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background: The TEACHH and Chow models were developed to predict life expectancy (LE) in patients evaluated for palliative radiotherapy (PRT). We sought to validate the TEACHH and Chow models in patients who died within 90 days of PRT consultation.

Methods: A retrospective review was conducted on patients evaluated for PRT from 2017 to 2019 who died within 90 days of consultation. Read More

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http://dx.doi.org/10.1002/cam4.3257DOI Listing

Exosomes released from M2 macrophages transfer miR-221-3p contributed to EOC progression through targeting CDKN1B.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

In contrast to other solid tumors within the abdominal cavity, epithelial ovarian cancers (EOCs) tend to undergo peritoneal metastasis. Thus, the peritoneal immune microenvironment is crucial for EOC progression. Previous reports indicate that the main immune cells within the peritoneum are M2 macrophages, specifically tumor-associated macrophages (TAMs). Read More

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http://dx.doi.org/10.1002/cam4.3252DOI Listing

Progesterone at high doses reduces the growth of U87 and A172 glioblastoma cells: Proteomic changes regarding metabolism and immunity.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosurgery, Acibadem Maslak Hospital and School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

While pregnancy may accelerate glioblastoma multiforme (GBM) growth, parity and progesterone (P4) containing treatments (ie, hormone replacement therapy) reduce the risk of GBM development. In parallel, low and high doses of P4 exert stimulating and inhibitory actions on GBM growth, respectively. The mechanisms behind the high-dose P4-suppression of GBM growth is unknown. Read More

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http://dx.doi.org/10.1002/cam4.3223DOI Listing

Development and validation of a pretreatment nomogram to predict overall survival in gastric cancer.

Cancer Med 2020 Jun 26. Epub 2020 Jun 26.

Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Background: Pretreatment clinical staging is essential to select therapy. However, there have been no published pretreatment gastric cancer nomograms constructed using pretreatment clinical prognostic factors, including in nonresection patients. We aimed to develop a new pretreatment gastric cancer nomogram for individualized prediction of overall survival (OS). Read More

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http://dx.doi.org/10.1002/cam4.3225DOI Listing

The effectiveness of chemotherapy for patients with pT3N0M0 renal pelvic urothelial carcinomas: An inverse probability of treatment weighting comparison using Surveillance, Epidemiology, and End Results data.

Cancer Med 2020 Jun 25. Epub 2020 Jun 25.

Department of Urology, Cancer Center, Sun Yat-sen University, Guangzhou, China.

Introduction: Unlike the established evidence to use chemotherapy for urothelial carcinoma of the bladder, presently there are insufficient data to inform a recommendation on upper urinary tract urothelial carcinoma treatment. The prognosis for patients with stage T4 and positive lymph nodes is poor; however, primary tumors in the renal pelvis are associated with favorable prognoses compared to those located in the ureter. Our study aimed at investigating the effectiveness of chemotherapy in patients with pT3N0M0 renal pelvic urothelial carcinomas (RPUC) who have relative favorable prognosis. Read More

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http://dx.doi.org/10.1002/cam4.3238DOI Listing

Trabecular bone deterioration in differentiated thyroid cancer: Impact of long-term TSH suppressive therapy.

Cancer Med 2020 Jun 25. Epub 2020 Jun 25.

Service of Endocrinology, University Hospital 12 de Octubre, Madrid, Spain.

Background: Conflicting results has been reported regard osteoporosis and fractures in patients with Differentiated Thyroid Cancer (DTC). Our objective was to evaluate the long-term effects of TSH suppression therapy with Levothyroxine (LT4) on trabecular bone score (TBS) and bone mineral density (BMD) in females with DTC after thyroidectomy.

Methods: About 145 women with resected DTC and receiving long-term TSH therapy, were stratified according to the degree of TSH suppression. Read More

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http://dx.doi.org/10.1002/cam4.3200DOI Listing

Uridine phosphorylase 1 is a novel immune-related target and predicts worse survival in brain glioma.

Cancer Med 2020 Jun 24. Epub 2020 Jun 24.

Department of Pediatrics, Futian Women and Children Health Institute, Shenzhen, People's Republic of China.

Uridine phosphorylase 1 (UPP1) has been reported as an oncogene in several malignancies. In glioma, the role of UPP1 remains unclear. This study was performed to explore its role in glioma at transcriptional level. Read More

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http://dx.doi.org/10.1002/cam4.3251DOI Listing

The efficacy and safety of neoadjuvant chemotherapy on patients with advanced gastric cancer: A multicenter randomized clinical trial.

Cancer Med 2020 Jun 24. Epub 2020 Jun 24.

Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Objectives: Exploring the efficacy and safety of perioperative chemotherapy on patients with AGC at different clinical and pathological stages.

Methods: A phase III randomized, multicenter, trial comparing adjuvant (arm A) or perioperative S-1 plus oxaliplatin (SOX, arm B), and perioperative capecitabine plus oxaliplatin (XELOX, arm C) was initiated in T3/4, node + gastric cancer patients (unclear). Each patient received an 8-cycle chemotherapy (3 weeks for one cycle). Read More

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http://dx.doi.org/10.1002/cam4.3224DOI Listing

Wound healing after excision of subcutaneous tumors treated with near-infrared photoimmunotherapy.

Cancer Med 2020 Jun 24. Epub 2020 Jun 24.

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer therapy that employs a combination of infrared light and tumor-targeted monoclonal antibody-photoabsorber conjugates to cause both direct tumor necrosis and immunogenic cell death. NIR-PIT may have potential in the perioperative setting before surgery, and therefore it is important to know the effect of NIR-PIT on wound healing. Fifty mice were implanted with subcutaneous xenografts of N87 human gastric cancer cells, and tumors were excised after reaching a predetermined size. Read More

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http://dx.doi.org/10.1002/cam4.3247DOI Listing

Clinical outcomes among unresectable, locally advanced, and metastatic cutaneous squamous cell carcinoma patients treated with systemic therapy.

Cancer Med 2020 Jun 24. Epub 2020 Jun 24.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.

Prior studies of conventional chemotherapy or epidermal growth factor receptor inhibitors for advanced (ie, locally advanced cutaneous squamous cell carcinoma [laCSCC] or metastatic [mCSCC]) cutaneous squamous cell cancer enrolled ≤ 40 patients. This retrospective, observational study assessed real-world treatment patterns and clinical outcomes in patients with unresectable laCSCC or mCSCC using electronic health records of patients who initiated first-line (1L) systemic treatment from 1 January 2008 to 31 December 2015, with follow-up to 30 September 2017. The median duration of follow-up from 1L treatment was 10. Read More

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http://dx.doi.org/10.1002/cam4.3146DOI Listing

Sex differences in solid pseudopapillary neoplasm of the pancreas: A population-based study.

Cancer Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Pancreatobiliary Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Objective: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor. This study aims to examine the clinicopathological features and surgical treatments of SPN and compare the clinical behavior and prognosis between men and women with SPN.

Methods: We collected the population data of patients with SPN diagnosed between 2004 and 2017 from the SEER database. Read More

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http://dx.doi.org/10.1002/cam4.3180DOI Listing

Racial and ethnic disparities in mortality from gastric and esophageal adenocarcinoma.

Cancer Med 2020 Jun 23. Epub 2020 Jun 23.

Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.

Background: Racial/ethnic differences in mortality have not been well studied for either non-cardia gastric cancer (NCGC) or cardia gastric cancer (CGC). The aim of this study was to examine the US mortality rates for these cancer subtypes, as well as esophageal adenocarcinoma (EAC) as a comparator.

Methods: We identified 14 164 individuals who died from NCGC, 5235 from CGC, and 13 982 from EAC in the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Read More

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http://dx.doi.org/10.1002/cam4.3063DOI Listing

Assessment of expression levels of leptin and leptin receptor as potential biomarkers for risk of prostate cancer development and aggressiveness.

Cancer Med 2020 Jun 23. Epub 2020 Jun 23.

Faculty of Medicine, Biochemistry Department, Umm Al-Qura University, Makkah, Saudi Arabia.

Background: Prostate cancer (PCa) is one of the most frequently diagnosed cancers worldwide. Despite the growing evidence associating obesity and adipokines, particularly leptin and its receptors, with cancer development and progression, it is still a debatable matter in PCa.

Objectives: We aimed to assess the role of leptin and its receptors as potential biomarkers for the risk of PCa development and aggressiveness. Read More

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http://dx.doi.org/10.1002/cam4.3082DOI Listing

Mechanisms of Epstein-Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma.

Cancer Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Documented reports proved that Epstein-Barr virus (EBV) infection increased infiltration of Tregs in malignancy. However, the mechanism of EBV recruitment Tregs into nasopharyngeal carcinoma (NPC) tissues has not been detailed discussion.

Methods: Expression of EBV nuclear antigen 1 (EBNA1) and Foxp3 in NPC tissue samples was detected by immunohistochemistry. Read More

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http://dx.doi.org/10.1002/cam4.3213DOI Listing