2,438 results match your criteria Cancer Management and Research [Journal]


Anticancer Effects of ACT001 via NF-κB Suppression in Murine Triple-Negative Breast Cancer Cell Line 4T1.

Cancer Manag Res 2020 26;12:5131-5139. Epub 2020 Jun 26.

Lung Cancer Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.

Purpose: ACT001 is a novel sesquiterpene lactone derivative with anticancer effects, including the reversal of tamoxifen resistance in estrogen receptor-positive breast cancer cells. However, few studies have investigated the anticancer effects of ACT001 in triple-negative breast cancer (TNBC), a highly aggressive cancer with a poor prognosis. This study aimed to investigate the effects of ACT001 on TNBC and the potential mechanism underlying these effects. Read More

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http://dx.doi.org/10.2147/CMAR.S244748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326172PMC

The Novel Zinc Finger Protein 587B Gene, ZNF587B, Regulates Cell Proliferation and Metastasis in Ovarian Cancer Cells in vivo and in vitro.

Cancer Manag Res 2020 26;12:5119-5130. Epub 2020 Jun 26.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.

Background: The zinc finger protein 587B () is a novel cisplatin-sensitive gene that was identified in our previous research by using a genome-scale CRISPR-Cas9 knockout library in ovarian cancer (OC) cell lines. belongs to the C2H2-type zinc finger protein (ZFP) family. Many ZFP protein could inhibit tumor development and malignancy. Read More

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http://dx.doi.org/10.2147/CMAR.S252347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326209PMC

Decreased PTGDS Expression Predicting Poor Survival of Endometrial Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Immunohistochemical Validation.

Cancer Manag Res 2020 26;12:5057-5075. Epub 2020 Jun 26.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, People's Republic of China.

Purpose: To identify key pathogenic genes and reveal the potential molecular mechanisms of endometrial cancer (EC) using bioinformatics analysis and immunohistochemistry validation.

Materials And Methods: Through weighted gene co-expression network analysis (WGCNA), a co-expression network was constructed based on the top 25% variant genes in the GSE50830 dataset downloaded from gene expression omnibus (GEO). GO and KEGG pathway enrichment analyses were performed using the DAVID online tool. Read More

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http://dx.doi.org/10.2147/CMAR.S255753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326400PMC

Erratum: Validation of the Chinese Version of the Shame and Stigma Scale in Patients with Head and Neck Cancer [Corrigendum].

Authors:

Cancer Manag Res 2020 25;12:4957. Epub 2020 Jun 25.

[This corrects the article DOI: 10.2147/CMAR.S228843. Read More

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http://dx.doi.org/10.2147/CMAR.S264974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325734PMC

Circular RNA FOXO3 Suppresses Bladder Cancer Progression and Metastasis by Regulating MiR-9-5p/TGFBR2.

Cancer Manag Res 2020 25;12:5049-5056. Epub 2020 Jun 25.

Department of Urology, Qilu Hospital of Shandong University, Jinan 250012, People's Republic of China.

Background: Increasing evidence indicates that the dysregulation of circular RNAs (circRNAs) plays important roles in tumor progressions.

Methods: In this study, we first analyzed circ-FOXO3 level in bladder cancers (BCs), and then BC cell lines were transfected with circ-FOXO3 expression vector, and cell proliferation, migration, and invasion abilities were analyzed. We also used bioinformatics tools to predict potential-binding miRNAs for circ-FOXO3, and luciferase reporter assay was used for the verification of binding miRNAs. Read More

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http://dx.doi.org/10.2147/CMAR.S253412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323812PMC

Switching Fractioned R-CHOP Cycles to Standard R-CHOP Cycles Guided by Endoscopic Ultrasonography in Treating Patients with Primary Gastric Diffuse Large B-Cell Lymphoma.

Cancer Manag Res 2020 25;12:5041-5048. Epub 2020 Jun 25.

Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Background: Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) is a common subtype of extranodal non-Hodgkin lymphoma (NHL), with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) as the commonly used treatment regimen. However, full cycles of standard R-CHOP present the risk of severe bleeding or perforation, even leading to emergency surgery, especially for those with deep lesions in their first 1-2 cycles of treatment. This study aims to explore the safety and efficacy of fractioned R-CHOP (rituximab d0, 50% dose of CHOP d1 and d5) followed by standard R-CHOP cycles in PG-DLBCL patients guided by endoscopic ultrasonography (EUS). Read More

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http://dx.doi.org/10.2147/CMAR.S260974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323805PMC

Chinese Cancer Research in 2009-18 and the Disease Burden.

Cancer Manag Res 2020 25;12:5031-5040. Epub 2020 Jun 25.

King's College London, Institute of Cancer Policy, Guy's Hospital, London SE1 9RT, UK.

Objective: We investigated the correlation of cancer research in China with its disease burden and national or provincial wealth. We also compared China's research output with that of other Asian countries.

Methods: Chinese publications on cancer research for 2009-18 were retrieved from the Web of Science with a special filter giving high precision and recall. Read More

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http://dx.doi.org/10.2147/CMAR.S253276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323809PMC

Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer.

Cancer Manag Res 2020 25;12:5023-5030. Epub 2020 Jun 25.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, People's Republic of China.

Purpose: The early predictive values of diagnostic markers for lymph node metastasis (LNM) in endometrial cancer (EC) are still unclear at present. The purpose of this study is to explore the relationship between serum calcium and LNM in EC.

Methods: We identified all patients with EC who underwent surgery between January 2012 and December 2016. Read More

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http://dx.doi.org/10.2147/CMAR.S253914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323808PMC

Lidocaine Suppresses Cell Proliferation and Aerobic Glycolysis by Regulating circHOMER1/miR-138-5p/HEY1 Axis in Colorectal Cancer.

Cancer Manag Res 2020 25;12:5009-5022. Epub 2020 Jun 25.

Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, People's Republic of China.

Background: Increasing evidence has uncovered the anticancer activity of lidocaine in many cancers. However, the role and the underlying molecular mechanism of lidocaine in colorectal cancer (CRC) remain poorly understood.

Materials And Methods: Cell viability and apoptosis were measured by cell counting kit-8 assay and flow cytometry. Read More

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http://dx.doi.org/10.2147/CMAR.S244973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323806PMC

PD-L1 and miR-34a are Prognostic Factors for Primary Gastric Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP.

Cancer Manag Res 2020 25;12:4999-5008. Epub 2020 Jun 25.

Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, Changsha, People's Republic of China.

Introduction: Primary gastric diffuse large B-cell lymphoma (GDLBCL) is a heterogeneous disease in clinicopathological features and prognosis. Programmed death ligand-1 (PD-L1) and microRNA-34a (miR-34a) play crucial roles in GDLBCL progress. The purpose of this research is to explore the clinical significance of PD-L1 and miR-34a expression in GDLBCL. Read More

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http://dx.doi.org/10.2147/CMAR.S247874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323802PMC

Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer.

Cancer Manag Res 2020 25;12:4991-4997. Epub 2020 Jun 25.

Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

Purpose: Accumulating evidence suggests that microbiota dysbiosis induced by antibiotic administration plays a crucial role in regulating the efficacy and toxicity of cancer therapy. We explored the influence of antibiotic administration on the efficacy of chemotherapy in patients with esophageal cancer (EC).

Patients And Methods: EC patients were stratified into two groups: antibiotic-treated group and control group. Read More

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http://dx.doi.org/10.2147/CMAR.S248130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323800PMC

miRNA-181a-5p Enhances the Sensitivity of Cells to Cisplatin in Esophageal Adenocarcinoma by Targeting CBLB.

Cancer Manag Res 2020 25;12:4981-4990. Epub 2020 Jun 25.

Department of Oncology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, People's Republic of China.

Background: Cisplatin (CDDP) is extensively used for esophageal adenocarcinoma (EAC) chemotherapy, while cisplatin resistance is getting worse. microRNA-181a-5p (miR-181a-5p) has been reported to play an important role in various human cancers. However, the effect and underlying mechanism of miR-181a-5p in cisplatin resistance of EAC remain unclear. Read More

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http://dx.doi.org/10.2147/CMAR.S251264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323973PMC

Nosocomial Infections in Gastrointestinal Cancer Patients: Bacterial Profile, Antibiotic Resistance Pattern, and Prognostic Factors.

Cancer Manag Res 2020 25;12:4969-4979. Epub 2020 Jun 25.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.

Background: Cancers of the gastrointestinal (GI) tract and its associated excretory glands are one of the most common causes of cancer-related death worldwide, and these patients are more likely to developing nosocomial infections due to immunodeficiency.

Objective: To explore the bacterial profile, antibiotic resistance pattern, and prognostic factors of nosocomial infections in hospitalized GI cancer patients.

Methods: All electronic medical records of nosocomial infection episodes in hospitalized GI cancer patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.2147/CMAR.S258774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323960PMC

Down-Regulation of Ribosomal Protein RPS21 Inhibits Invasive Behavior of Osteosarcoma Cells Through the Inactivation of MAPK Pathway.

Cancer Manag Res 2020 25;12:4949-4955. Epub 2020 Jun 25.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province 030001, People's Republic of China.

Objective: The goal of our present study was to explore the expression level, biological function, and underlying molecular mechanism of ribosomal protein s21 (RPS21) in human osteosarcoma (OS).

Methods: Firstly, we evaluated the expression of RPS21 in OS tissue samples based on the Gene Expression Omnibus (GEO) datasets and also measured the RPS21 expression of OS cell lines (MG63, and U2OS) by quantitative real-time polymerase chain reaction (qRT-PCR). siRNA interference method was used to reduce the expression of RSP21 in the OS cells. Read More

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http://dx.doi.org/10.2147/CMAR.S246928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323807PMC

Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade.

Cancer Manag Res 2020 24;12:4937-4948. Epub 2020 Jun 24.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of China.

Background: Anlotinib is a highly potent multi-target tyrosine kinase inhibitor, with very good anti-tumor activity against a variety of solid tumors. However, its effect on colorectal cancer (CRC) is not yet clearly understood. The objective of this study was to investigate the anti-tumor effect and underlying mechanism of anlotinib in the pathogenesis of CRC. Read More

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http://dx.doi.org/10.2147/CMAR.S252181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321688PMC

Glucosamine-6-Phosphate Isomerase 1 Promotes Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma.

Cancer Manag Res 2020 24;12:4923-4935. Epub 2020 Jun 24.

Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, People's Republic of China.

Purpose: Reprogramming of metabolic pathways is a hallmark of the pathological changes that occur in cancer cells. Under physiological conditions, glucosamine-6-phosphate isomerase 1 (GNPDA1) promotes the conversion of the hexosamine system to the glycolytic pathway and may, therefore, affect energy metabolism. Low expression of GNPDA1 has been reported in normal liver tissues, however, analysis of the hepatocellular carcinoma (HCC) database in The Cancer Genome Atlas (TCGA) revealed that GNPDA1 was highly expressed in HCC tissues. Read More

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http://dx.doi.org/10.2147/CMAR.S250094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321694PMC

Impact of Amrubicin Monotherapy as Second-Line Chemotherapy on Outcomes in Elderly Patients with Relapsed Extensive-Disease Small-Cell Lung Cancer.

Cancer Manag Res 2020 23;12:4911-4921. Epub 2020 Jun 23.

Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-City, Kanagawa 252-0374, Japan.

Purpose: Amrubicin (AMR) is an anticancer drug for patients with relapsed small-cell lung cancer (SCLC). However, the efficacy of AMR in elderly patients with relapsed SCLC after chemotherapy by carboplatin plus etoposide (CE) has not been sufficiently evaluated.

Patients And Methods: The medical records of patients with relapsed SCLC who received AMR as second-line chemotherapy were retrospectively reviewed, and their treatment outcomes were evaluated. Read More

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http://dx.doi.org/10.2147/CMAR.S255552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320750PMC

CircRNA SMARCC1 Sponges MiR-140-3p to Regulate Cell Progression in Colorectal Cancer.

Cancer Manag Res 2020 23;12:4899-4910. Epub 2020 Jun 23.

Department of Pathology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, People's Republic of China.

Purpose: Our objective was to investigate the effect of circSMARCC1 on the developmental and biological behavior of colorectal cancer (CRC).

Materials And Methods: The expression of circSAMRCC1 and miR-140-3p in CRC tissues and cell lines (SW620, HCT116, HT29 and SW480) and a normal cell line (NCM460) was detected using qRT-PCR. The expression levels of circSMARCC1 and its linear subtype were detected. Read More

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http://dx.doi.org/10.2147/CMAR.S254185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320753PMC

CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway.

Cancer Manag Res 2020 23;12:4889-4898. Epub 2020 Jun 23.

Beijing YouAn Hospital, Capital Medical University, Beijing, People's Republic of China.

Background: Laryngeal carcinoma is a common cancer among head and neck tumors, accounting for 0.5-1% new cancer cases or deaths of all tumors throughout the body. Despite improvements in diagnostic and therapy, the prognosis of laryngeal carcinoma patients still remains poor. Read More

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http://dx.doi.org/10.2147/CMAR.S241620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320751PMC

Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma.

Cancer Manag Res 2020 23;12:4883-4888. Epub 2020 Jun 23.

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.

Objective: To study the effect of cryptorchidism on clinical stage (CS) of testicular seminoma (TS).

Patients And Methods: In the Surveillance Epidemiology and End Results (SEER) database (2006-2016), people with TS were enrolled in our research. Multivariable logistic regression models were constructed to compare the impact of cryptorchidism on CS. Read More

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http://dx.doi.org/10.2147/CMAR.S236618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320749PMC

Ipilimumab and Nivolumab as First-Line Treatment of Patients with Renal Cell Carcinoma: The Evidence to Date.

Cancer Manag Res 2020 23;12:4871-4881. Epub 2020 Jun 23.

Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Center Institute, Cleveland, OH, USA.

Immunotherapy has revolutionized the management of metastatic renal cell carcinoma with four checkpoint inhibitors (nivolumab, ipilimumab, avelumab, and pembrolizumab) approved either as monotherapy or as combination therapy. The use of ipilimumab and nivolumab for treatment-naïve, intermediate to poor risk, metastatic renal cell carcinoma was the first checkpoint inhibitor-based combination therapy and remains the only dual checkpoint inhibitor combination approved in mRCC. In this article, we review the trials that led to the approval of ipilimumab and nivolumab in this setting. Read More

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http://dx.doi.org/10.2147/CMAR.S202017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320748PMC

A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.

Cancer Manag Res 2020 23;12:4855-4869. Epub 2020 Jun 23.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Background: In our previous study, serine protease inhibitor Kazal-type 5 (SPINK5), which encodes the product of serine protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) was found to be down-regulated in head and neck squamous cell carcinoma (HNSCC) using oligonucleotide microarrays. However, the function and clinical implications of SPINK5/LEKTI remain obscure in HNSCC.

Methods: The endogenous expression level of SPINK5/LEKTI was further verified in 9 HNSCC cell lines and HNSCCs by means of reverse transcription-polymerase chain reaction, real-time PCR, Western blotting and immunohistochemistry. Read More

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http://dx.doi.org/10.2147/CMAR.S236266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320891PMC

Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study.

Cancer Manag Res 2020 23;12:4841-4854. Epub 2020 Jun 23.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.

Introduction: Breast cancer is the second most common cancer in women across the world. Some of the patients who present in the early stage of disease are affected by metastasis to the axillary group of lymph nodes. The first among this group that is affected is called as sentinel lymph node, and its diagnosis is crucial for the staging of cancer thereby dictating the type of surgical therapy. Read More

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http://dx.doi.org/10.2147/CMAR.S255684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320752PMC

Information Seeking Behavior About Cancer and Associated Factors Among University Students, Ethiopia: A Cross-Sectional Study.

Cancer Manag Res 2020 22;12:4829-4839. Epub 2020 Jun 22.

Department of Health Informatics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Cancer is among the leading cause of death in sub-Saharan Africa over the last few years, putting a tremendous physical, emotional, and financial strain on individuals, families, and health systems. Many health systems in sub-Saharan Africa are least prepared to manage this burden, and a large number of individuals do not have access to quality cancer-related information to prevent and manage cancer. Understanding the information seeking behavior of individuals, especially university students who are more likely to seek health information than other people, can be seen as an opportunity to provide resources to improve lifestyle or prevent possible health-threatening behaviors of individuals. Read More

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http://dx.doi.org/10.2147/CMAR.S259849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319524PMC

Aurora-B Promotes Osteosarcoma Cell Growth and Metastasis Through Activation of the NPM1/ERK/NF-κβ/MMPs Axis.

Cancer Manag Res 2020 23;12:4817-4827. Epub 2020 Jun 23.

Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China.

Purpose: Osteosarcoma (OS) is the most common primary malignant tumor of the bone in young adolescents and children. We explored the underlying mechanism of Aurora-B in promoting OS cell proliferation and metastasis.

Patient And Methods: Bioinformatics was employed to predict the substrate of Aurora-B. Read More

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http://dx.doi.org/10.2147/CMAR.S252847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320907PMC

The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism.

Cancer Manag Res 2020 22;12:4807-4815. Epub 2020 Jun 22.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan 250012, People's Republic of China.

Purpose: Accumulating evidence indicates that circular RNAs (circRNAs) are closely involved in canceration and cancer progression. However, the role of circRNAs in cervical cancer (CC) is largely unknown. Here, we characterized the role of circRNA_101308 in CC. Read More

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http://dx.doi.org/10.2147/CMAR.S242615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319513PMC

MiR-34a Inhibits Cell Proliferation and Induces Apoptosis in Human Nasopharyngeal Carcinoma by Targeting lncRNA MCM3AP-AS1.

Cancer Manag Res 2020 22;12:4799-4806. Epub 2020 Jun 22.

Department of Oncology, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou City, Guangxi Province 545001, People's Republic of China.

Introduction: MCM3AP-AS1 has been characterized as an oncogenic lncRNA in several types of cancer, while its role in nasopharyngeal carcinoma (NPC) is unknown. This study aimed to investigate the role of MCM3AP-AS1 in NPC.

Patients And Methods: Paired NPC tissues and non-tumor tissues were collected from 55 NPC patients. Read More

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http://dx.doi.org/10.2147/CMAR.S245520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319531PMC

Biochemical Markers of Colorectal Cancer - Present and Future.

Cancer Manag Res 2020 22;12:4789-4797. Epub 2020 Jun 22.

Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.

According to a report by the National Cancer Institute, colorectal cancer (CRC) is one of the most common types of cancer worldwide. CRC is often recognized too late for successful therapy. Tumor markers have been sought for a number of years to detect the transformation of malignant cells at the earliest possible stage. Read More

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http://dx.doi.org/10.2147/CMAR.S253369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319530PMC

Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib.

Cancer Manag Res 2020 22;12:4777-4787. Epub 2020 Jun 22.

Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China.

Introduction: Skp2 is an E3 ubiquitin ligase that plays an important role in modulating tumor progression. The mechanisms underlying Skp2 in the promotion of proliferation and its function in the primary resistance to tyrosine kinase inhibitors (TKIs) in human CML remain to be determined. This study aimed to investigate the function of Skp2 in CML progression as well as its effects on TKI sensitivity. Read More

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http://dx.doi.org/10.2147/CMAR.S253367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319929PMC

The Role and Mechanism of S1PR5 in Colon Cancer.

Cancer Manag Res 2020 19;12:4759-4775. Epub 2020 Jun 19.

Key Laboratory of Nanobiological Technology of National Health Commission of China, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Purpose: To investigate the role and mechanism of S1PR5 in colon cancer.

Materials And Methods: Lentiviral infection and drug screening helped to establish colon cancer cell lines with stable overexpression and knockdown of S1PR5. Effects of S1PR5 expression on cell growth, proliferation, migration, and invasion were analyzed using a subcutaneous xenograft model in nude mice. Read More

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http://dx.doi.org/10.2147/CMAR.S239118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311188PMC

Knockdown of lncRNA HCP5 Suppresses the Progression of Colorectal Cancer by miR-299-3p/PFN1/AKT Axis.

Cancer Manag Res 2020 19;12:4747-4758. Epub 2020 Jun 19.

Department of Laboratory Medicine, The Affiliated Xi'an Centre Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710003, People's Republic of China.

Background: Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system. The lncRNA HCP5 has been reported to affect the progression of tumor in several types of cancer. Here, in this research, we focus on the role and function of lncRNA HCP5 in human colorectal cancer. Read More

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http://dx.doi.org/10.2147/CMAR.S255866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310975PMC

Upregulated SET Promotes Cell Survival Through Activating Akt/NF-κB Signal in Colorectal Carcinoma.

Cancer Manag Res 2020 19;12:4735-4745. Epub 2020 Jun 19.

Department of Medical Cellular Biology and Genetics, Shanxi Medical University, Taiyuan 030001, People's Republic of China.

Purpose: SET has been proven to be an oncogene, which promotes the initiation and progression in several kinds of malignant carcinomas. However, the expression and its functional roles in colorectal carcinoma (CRC) remained unknown.

Materials And Methods: CRC tissues samples, CRC cell lines and xenograft mouse tumors were used in this study. Read More

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http://dx.doi.org/10.2147/CMAR.S255930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310974PMC

Optimal Laparoscopic Management and Oncological Outcomes of Gastrointestinal Stromal Tumors in Duodenum: Pancreaticoduodenectomy or Pancreas-Sparing Duodenectomy?

Cancer Manag Res 2020 19;12:4725-4734. Epub 2020 Jun 19.

Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, People's Republic of China.

Background: Gastrointestinal stromal tumors (GIST) of the duodenum are rarely reported and optimal minimally invasive management has not been well proposed. Pancreaticoduodenectomy and different types of pancreas-sparing duodenectomy can be chosen; however, which to choose and its corresponding clinical outcomes and oncological concerns remain controversial.

Patients And Methods: Patients diagnosed with GIST of duodenum underwent laparoscopic pancreaticoduodenectomy (L-PD) or pancreas-sparing duodenectomy (L-PSD) in Zhejiang Provincial People's Hospital were enrolled. Read More

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http://dx.doi.org/10.2147/CMAR.S254972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310982PMC

Overexpression of lncRNA MT1JP Mediates Apoptosis and Migration of Hepatocellular Carcinoma Cells by Regulating miR-24-3p.

Cancer Manag Res 2020 18;12:4715-4724. Epub 2020 Jun 18.

College of Biological Science and Technology, University of Jinan, Jinan, Shandong Province 250022, People's Republic of China.

Objective: This study aimed to determine the effects of the long non-coding (lnc) RNA MT1JP on the apoptosis and migration of hepatocellular carcinoma cells.

Patients And Methods: Patients with liver cancer admitted to the Second People's Hospital of Liaocheng were included in this study. We transfected hepatocellular carcinoma cells with MT1JP and miR-24-3p and assessed their expression and effects on apoptosis and migration. Read More

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http://dx.doi.org/10.2147/CMAR.S249582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308148PMC

Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma.

Cancer Manag Res 2020 18;12:4699-4714. Epub 2020 Jun 18.

Department of Dermatology, Xi'an Central Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

Background: Melanoma is aggressive and lethal melanocytic neoplasm, and its incidence has increased worldwide in recent decades. Accumulating evidence has showed that various long noncoding RNAs (lncRNAs) participated in occurrence of malignant tumors, including melanoma. The present study was designed to investigate function of lncRNA colon cancer-associated transcript-1 (CCAT1) in melanoma. Read More

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http://dx.doi.org/10.2147/CMAR.S252635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308122PMC

CFTR Regulates the Proliferation, Migration and Invasion of Cervical Cancer Cells by Inhibiting the NF-κB Signalling Pathway.

Cancer Manag Res 2020 18;12:4685-4697. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Chengdu, Sichuan, People's Republic of China.

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) and nuclear factor κB (NF-κB) signalling pathways are currently regarded as co-regulators of the occurrence of cervical cancer. However, the detailed mechanism of CFTR- and NF-κB-mediated effects in cervical cancer remains to be elucidated. This study aimed to investigate the mechanism by which CFTR and NF-κB influence the development of cervical cancer. Read More

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http://dx.doi.org/10.2147/CMAR.S252296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308183PMC

DNA Methylation in Gene as a Mediator of the Association Between Healthy Lifestyle and Breast Cancer: A Case-Control Study.

Cancer Manag Res 2020 18;12:4677-4684. Epub 2020 Jun 18.

Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin 150081, Heilong Jiang Province, People's Republic of China.

Purpose: Lifestyle factors and methylation in the retinoic acid receptor β () gene are associated with breast cancer (BC). This study aims to examine the mediation effect of methylation on the association between healthy lifestyle and BC in Chinese women.

Patients And Methods: This case-control study consisted of 408 BC patients and 573 controls. Read More

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http://dx.doi.org/10.2147/CMAR.S244606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308131PMC

Monitoring Value of Serum HER2 as a Predictive Biomarker in Patients with Metastatic Breast Cancer.

Cancer Manag Res 2020 18;12:4667-4675. Epub 2020 Jun 18.

Department of Immunology, Key Laboratory of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, People's Republic of China.

Purpose: The aim of this study was to investigate the monitoring value of serum HER2 in patients with metastatic breast cancer.

Patients And Methods: We firstly evaluated the association of serum HER2 levels with tissue HER2 expression and imaging results in 420 breast cancer patients admitted into Tianjin Medical University Cancer Institute and Hospital between April 2016 and December 2018. Secondly, we analyzed serum HER2 levels in breast cancer patients with different metastatic degrees. Read More

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http://dx.doi.org/10.2147/CMAR.S254897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308125PMC

Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo.

Cancer Manag Res 2020 17;12:4645-4665. Epub 2020 Jun 17.

Diabetes Research Laboratory, Department of Research, Changhua Christian Hospital, Changhua, Taiwan.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with an overall 5-year survival rate of 9.3%, and this malignancy is expected to become the second leading cause of cancer-related death by 2030. Gemcitabine resistance develops within weeks of PDAC patient's chemotherapeutic initiation. Read More

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http://dx.doi.org/10.2147/CMAR.S247876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306478PMC

Icotinib as Adjuvant Treatment for Stage II-IIIA Lung Adenocarcinoma Patients with EGFR Mutation (ICWIP Study): Study Protocol for a Randomised Controlled Trial.

Cancer Manag Res 2020 17;12:4633-4643. Epub 2020 Jun 17.

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

The efficacy and possible role of epidermal growth factor receptor tyrosine kinase inhibitors in treating early-stage non-small-cell lung cancer have yet to be established. Therefore, we aimed to explore the efficacy and safety of icotinib in completely resected EGFR-mutant stage II-IIIA lung adenocarcinoma patients who underwent standard chemotherapy. This is a randomised, double-blinded, placebo-controlled, multicentre, Phase III trial. Read More

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http://dx.doi.org/10.2147/CMAR.S240275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306474PMC

CD56 Expression Is Associated with Biological Behavior of Pancreatic Neuroendocrine Neoplasms.

Cancer Manag Res 2020 17;12:4625-4631. Epub 2020 Jun 17.

Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 2100029, People's Republic of China.

Purpose: CD56 is a neural cell adhesion molecule that plays a role in the cohesiveness of neuroendocrine cells. The aim of this study was to explore the biological values of CD56 expression in pancreatic neuroendocrine neoplasms (PNENs) and its role in predicting PNENs grades.

Patients And Methods: A total of 138 patients with histological-proven PNENs was included (66 G1, 46 G2 and 26 G3). Read More

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http://dx.doi.org/10.2147/CMAR.S250071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306468PMC

Spatial Variation in Lung Cancer Mortality and Related Men-Women Disparities in Iran from 2011 to 2014.

Cancer Manag Res 2020 17;12:4615-4624. Epub 2020 Jun 17.

Iranian Ministry of Health and Medical Education, Tehran, Iran.

Purpose: Lung cancer is considered as a common cause of cancer mortality. The disease represents the second and third causes of deaths from cancer among Iranian women and men, respectively. The present study aimed to evaluate the spatial variations in relative risk of lung cancer mortality in Iran and its relation to common risk factors between men and women and specific risk factors among women. Read More

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http://dx.doi.org/10.2147/CMAR.S247178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306464PMC

Silencing of lncRNA LINC00346 Inhibits the Proliferation and Promotes the Apoptosis of Colorectal Cancer Cells Through Inhibiting JAK1/STAT3 Signaling.

Authors:
Dan Li Shuang Wen

Cancer Manag Res 2020 16;12:4605-4614. Epub 2020 Jun 16.

Department of Pathology, The Friendship Hospital of Dalian, Dalian City, Liaoning Province 116000, People's Republic of China.

Purpose: The study was aimed to investigate the effect and mechanism of lncRNA LINC00346 on cell proliferation and apoptosis of colorectal cancer (CRC).

Methods: The expression of lncRNA LINC00346 in CRC tissues and cells was detected by qRT-PCR. LINC00346 was overexpressed and silenced in HT29 and LoVo cells by the transfection of pcDNA-LINC00346 and si-LINC00346. Read More

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http://dx.doi.org/10.2147/CMAR.S249491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305831PMC

Regulation of Autophagy by Non-Steroidal Anti-Inflammatory Drugs in Cancer.

Cancer Manag Res 2020 16;12:4595-4604. Epub 2020 Jun 16.

Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Shanxi, People's Republic of China.

Cancer is the leading cause of death, placing a substantial global health burden. The development of the most effective treatment regimen is the unmet clinical need for cancer. Inflammation plays a role in tumorigenesis and progression, and anti-inflammation may be a promising option for cancer management and prevention. Read More

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http://dx.doi.org/10.2147/CMAR.S253345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305821PMC

Multiple Immune-Related Adverse Events and Anti-Tumor Efficacy: Real-World Data on Various Solid Tumors.

Cancer Manag Res 2020 16;12:4585-4593. Epub 2020 Jun 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Purpose: Immune checkpoint inhibitors (ICIs) have been approved for various types of cancer; however, they cause a broad spectrum of immune-related adverse events (irAEs). The association between the development of irAEs and the clinical benefit remains uncertain. We aimed to evaluate the association of irAEs and the treatment efficacy in real-world practice. Read More

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http://dx.doi.org/10.2147/CMAR.S247554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305832PMC

Localization of Nuclei in Breast Cancer Using Whole Slide Imaging System Supported by Morphological Features and Shape Formulas.

Cancer Manag Res 2020 16;12:4573-4583. Epub 2020 Jun 16.

School of Computer Science, University of Petroleum and Energy Studies, Dehradun 248007, India.

Purpose: Cancer rates are exponentially increasing worldwide and over 15 million new cases are expected in the year 2020 according to the World Cancer Report. To support the clinical diagnosis of the disease, recent technical advancements in digital microscopy have been achieved to reduce the cost and increase the efficiency of the process. Food and Drug Administration (FDA or Agency) has issued the guidelines, in particular, the development of digital whole slide image scanning system. Read More

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http://dx.doi.org/10.2147/CMAR.S248166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305844PMC

Effect of LINC00657 on Apoptosis of Breast Cancer Cells by Regulating miR-590-3p.

Cancer Manag Res 2020 15;12:4561-4571. Epub 2020 Jun 15.

College of Biological Science and Technology, University of Jinan, Jinan 250022, People's Republic of China.

Objective: To investigate the effect of LINC00657 on breast carcinoma by regulating miR-590-3p.

Methods: Ninety-seven cases with breast carcinoma who were admitted to Qingdao Chengyang People's Hospital were collected. The breast carcinoma (n=97) and tumor-adjacent tissues (n=97) of patients were collected during the operation with the permission of the patients. Read More

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http://dx.doi.org/10.2147/CMAR.S249576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305342PMC

Prospective Study of the Clinical Impact of Epithelial and Mesenchymal Circulating Tumor Cells in Localized Prostate Cancer.

Cancer Manag Res 2020 15;12:4549-4560. Epub 2020 Jun 15.

Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People's Republic of China.

Background: Although circulating tumor cells (CTCs) are considered as a surrogate marker in monitoring disease progression and treatment response in late stage prostate cancer (PCa), its clinical impact in localized PCa remains unclear, indicating the limitation that is simply based on cell count. This perspective observational study aimed to detect the epithelial-to-mesenchymal transition (EMT) subtypes of CTCs in localized PCa and analyze their clinical relevance and application in predicting PCa stages before surgery compared with the Partin table.

Patients And Methods: Between August 2017 and April 2019, 80 newly diagnosed localized PCa patients were enrolled in the study. Read More

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http://dx.doi.org/10.2147/CMAR.S253997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304675PMC

Cell Differentiation Agent-2 (CDA-2) Inhibits the Growth and Migration of Saos-2 Cells via miR-124/MAPK1.

Cancer Manag Res 2020 15;12:4541-4548. Epub 2020 Jun 15.

Department of Oncology, Hospital of Ruikang Affiliated to Guangxi University of Chinese Medicine, Guangxi, People's Republic of China.

Background: CDA-2 (cell differentiation agent 2), isolated from healthy human urine, exerts antitumor effects in multiple types of cancer cells. However, its role in osteosarcoma has not been studied.

Methods: The MTT assay was used to examine the cell proliferation rate. Read More

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http://dx.doi.org/10.2147/CMAR.S248851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304673PMC

LncRNA TDRG1 Promotes Proliferation, Invasion and Epithelial-Mesenchymal Transformation of Osteosarcoma Through PI3K/AKT Signal Pathway.

Cancer Manag Res 2020 15;12:4531-4540. Epub 2020 Jun 15.

Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, People's Republic of China.

Objective: This study aimed to investigate the effect of long non-coding TDRG1 on proliferation and migration of osteosarcoma cells through PI3K/AKT signaling pathway.

Materials And Methods: Altogether 87 cases of osteosarcoma tissues and adjacent tissues were collected, and osteosarcoma cells and osteoblasts were purchased. The expression of LncRNA TDRG1 in tissues and cells was detected by RT-PCR. Read More

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http://dx.doi.org/10.2147/CMAR.S248964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304679PMC