1,098 results match your criteria Cancer Management and Research [Journal]


miR-600 inhibits lung cancer via downregulating the expression of METTL3.

Cancer Manag Res 2019 1;11:1177-1187. Epub 2019 Feb 1.

Department of Respiratory Medicine, The Second People's Hospital of Dongying, Guangrao City, Shandong Province 257335, People's Republic of China,

Background: Methyltransferase like 3 (METTL3) is an RNA methyltransferase implicated in mRNA biogenesis, decay, and translation control through N-methyladenosine (mA) modification.

Methods: To find new treatment strategies for lung cancer and to elucidate the mechanism underlying the phenomenon, we treated the human lung cancer cell lines A549 and H1299 to investigate the effect of METTL3 on lung cancer.

Results: We observed that knockdown of METTL3 inhibited the survival and proliferation of A549 and H1299 cells. Read More

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http://dx.doi.org/10.2147/CMAR.S181058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362936PMC
February 2019

Rhein shows potent efficacy against non-small-cell lung cancer through inhibiting the STAT3 pathway.

Cancer Manag Res 2019 1;11:1167-1176. Epub 2019 Feb 1.

Department of Respiratory Medicine, Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, People's Republic of China,

Background: Non-small-cell lung cancer (NSCLC) comprises about 85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. The IL-6/STAT3 signaling pathway plays a pivotal role in NSCLC biology. Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Read More

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February 2019

Carbon-ion radiotherapy in accelerated hypofractionated active raster-scanning technique for malignant lacrimal gland tumors: feasibility and safety.

Cancer Manag Res 2019 1;11:1155-1166. Epub 2019 Feb 1.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg 69120, Germany,

Introduction: We evaluated treatment outcomes of CIRT in an active raster-scanning technique alone or in combination with IMRT for lacrimal gland tumors.

Methods: A total of 24 patients who received CIRT for a malignant lacrimal gland tumor at the HIT between 2009 and 2018 were analyzed retrospectively for LC, OS, and distant progression-free survival (DPFS) using Kaplan-Meier estimates. Toxicity was assessed according to the CTCAE version 5. Read More

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http://dx.doi.org/10.2147/CMAR.S190051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362930PMC
February 2019

Dexamethasone inhibits the proliferation of tumor cells.

Cancer Manag Res 2019 1;11:1141-1154. Epub 2019 Feb 1.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow, China.

Objective: Dexamethasone (DEX) is a glucocorticoid that is commonly used in clinics. Previously, DEX has been shown to inhibit the function of immune system; however, DEX is often used to treat side reactions, such as nausea and vomiting caused by chemotherapy in clinics. Therefore, it is necessary to study the role of DEX in the treatment of cancer. Read More

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http://dx.doi.org/10.2147/CMAR.S187659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362917PMC
February 2019

Performance characteristics of prostate-specific antigen density and biopsy primary Gleason score to predict biochemical failure in patients with intermediate prostate cancer who underwent radical prostatectomy.

Cancer Manag Res 2019 1;11:1133-1139. Epub 2019 Feb 1.

Department of Urology, First Affiliated Hospital of Soochow University, Suzhou 215006, China,

Background: Prognosis for intermediate-risk prostate cancer (PCa) remains variable; therefore, we aimed to investigate high-risk factors for biochemical recurrence (BCR), and intermediate-risk PCa using radical prostatectomy to identify patients having equivalent BCR-free survival rates when compared to high-risk PCa.

Patients And Methods: A total of 441 medical records were analyzed, including those of 169 intermediate-risk and 272 high-risk PCa patients. Risk factors for time to BCR were tested and analyzed using Kaplan-Meier survival analysis, log-rank tests, and Cox proportion hazards models. Read More

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http://dx.doi.org/10.2147/CMAR.S190443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362965PMC
February 2019

SERS-based detection of haptoglobin in ovarian cyst fluid as a point-of-care diagnostic assay for epithelial ovarian cancer.

Cancer Manag Res 2019 31;11:1115-1124. Epub 2019 Jan 31.

Laboratory of Bio-optical Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (ASTAR), Singapore,

Purpose: To evaluate haptoglobin (Hp) in ovarian cyst fluid as a diagnostic biomarker for epithelial ovarian cancers (EOCs) using surface-enhanced Raman spectroscopy (SERS)-based in vitro diagnostic assay for use in an intraoperative setting.

Methods: SERS-based method was used to detect and quantify Hp in archived ovarian cyst fluids collected from suspicious ovarian cysts and differentiate benign tumors from EOCs. The diagnostic performance of SERS-based assay was verified against the histopathology conclusions and compared with the results of CA125 test and frozen sections. Read More

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http://dx.doi.org/10.2147/CMAR.S185375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362937PMC
January 2019

Pathological risk factors for lymph node metastasis in patients with submucosal invasive colorectal carcinoma.

Cancer Manag Res 2019 30;11:1107-1114. Epub 2019 Jan 30.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Background: Risk grade assessment determines therapy in patients with submucosal invasive colorectal carcinoma (CRC). However, treatment decisions are often difficult due to a lack of consensus on which risk factors should be considered. We aimed to identify predictive risk factors for lymph node metastasis (LNM) in a large cohort of submucosal invasive CRC patients from China. Read More

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http://dx.doi.org/10.2147/CMAR.S181740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361223PMC
January 2019

Postmastectomy radiotherapy using three different techniques: a retrospective evaluation of the incidental dose distribution in the internal mammary nodes.

Cancer Manag Res 2019 30;11:1097-1106. Epub 2019 Jan 30.

Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong 250117, China,

Objective: To evaluate the incidental coverage dose to the internal mammary nodes (IMN) in patients treated with postmastectomy radiotherapy (PMRT) and its relationship with the treatment plan.

Patients And Methods: We retrospectively analyzed 138 patients undergoing PMRT and divided them into three groups: three-dimensional conformal radiotherapy (3D-CRT), field-in-field forward intensity-modulated radiotherapy (F-IMRT), and inverse intensity-modulated radiotherapy (I-IMRT). The IMN were contoured according to the Radiation Therapy Oncology Group consensus and not included in the planning target volume. Read More

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http://dx.doi.org/10.2147/CMAR.S191047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361227PMC
January 2019

Identifying the reasons for delayed presentation of Pakistani breast cancer patients at a tertiary care hospital.

Cancer Manag Res 2019 29;11:1087-1096. Epub 2019 Jan 29.

Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Punjab, Pakistan,

Background: Delay in seeking health care by breast cancer patients is associated with advanced stage of disease at presentation and poor survival rates. This study aimed to identify the reasons for delayed presentation and their association with various sociodemographic variables.

Methods: A total of 200 female patients with abnormal clinical findings, ie, lump or palpable mass, were consecutively invited for this study. Read More

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http://dx.doi.org/10.2147/CMAR.S180388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357878PMC
January 2019

Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients.

Cancer Manag Res 2019 29;11:1081-1085. Epub 2019 Jan 29.

Department of Ear, Nose, and Throat, Affiliated Children Hospital of Zhengzhou University, Zhengzhou, China.

Background: The goal of this study was to investigate the long-term oncologic outcome of parotid mucoepidermoid carcinoma (MEC) in pediatric patients.

Patients And Methods: Patients <19 years old who were diagnosed with MEC from January 1990 to December 2017 were retrospectively enrolled in this study. The main analyzed indexes included intraparotid node (IPN) metastasis, neutrophil-tolymphocyte ratio (NLR), loco-regional control (LRC), and disease-specific survival (DSS) rates. Read More

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http://dx.doi.org/10.2147/CMAR.S192788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357880PMC
January 2019

Expression and biological function of rhotekin in gastric cancer through regulating p53 pathway.

Cancer Manag Res 2019 25;11:1069-1080. Epub 2019 Jan 25.

Department of Clinical Laboratory and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China,

Background/aim: Gastric cancer (GC) is one of a most threatening cancer globally. Rhotekin (RTKN), a Rho effector, has been reported to be upregulated in GC tissues. This study aimed to investigate the underlying regulatory roles of RTKN in the biological behavior of GC. Read More

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http://dx.doi.org/10.2147/CMAR.S185345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354689PMC
January 2019

Competing risk analysis of primary tracheal carcinoma based on SEER database.

Cancer Manag Res 2019 24;11:1059-1065. Epub 2019 Jan 24.

Department of Oncology, Chang'An Hospital, Xi'an, Shaanxi, China,

Purpose: To analyze the prognostic factors of primary tracheal carcinoma.

Patients And Methods: All patients of primary tracheal carcinoma were extracted from the Surveillance, Epidemiology, and End Results database during 1973-2015. The potential prognostic factors were analyzed by using the competing risk analysis of R statistical software. Read More

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http://dx.doi.org/10.2147/CMAR.S190124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353024PMC
January 2019

Prognostic value of miR17-92 family in patients with digestive system cancers: a systematic review and meta-analysis.

Cancer Manag Res 2019 22;11:1043-1058. Epub 2019 Jan 22.

Department of Clinical Laboratory, People's Liberation Army 159 Hospital, Zhumadian, Henan 463000, China.

The miR17-92 family is found to be aberrantly expressed and associated with clinicopathological characteristics in patients with various cancers, including digestive system cancers. However, its prognostic value is not yet established. Therefore, we performed a systematic review and meta-analysis to investigate the association between miR17-92-family expression and clinical outcomes in digestive system cancers. Read More

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http://dx.doi.org/10.2147/CMAR.S189113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349080PMC
January 2019

Circular RNA hsa_circ_0072309 inhibits proliferation and invasion of breast cancer cells via targeting miR-492.

Cancer Manag Res 2019 22;11:1033-1041. Epub 2019 Jan 22.

Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China,

Background: Although the number of circular RNAs (circRNAs) that has been identified in multiple cancer tissues continues to increase, the relationship between circRNA expression and carcinogenesis remains unknown. The role of hsa_circ_0072309 in breast cancer has remained undefined until now. In this study, we aimed to investigate the role of hsa_circ_0072309 in breast cancer progression. Read More

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http://dx.doi.org/10.2147/CMAR.S186857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349082PMC
January 2019

Synergistic cytotoxicity of homoharringtonine and etoposide in acute myeloid leukemia cells involves disrupted antioxidant defense.

Cancer Manag Res 2019 22;11:1023-1032. Epub 2019 Jan 22.

Department of Hematology, Affiliated Hospital of Jining Medical University, Jining 272029, Shandong Province, China,

Background/aims: Cytotoxicity induced by reactive oxygen species (ROS) is critical for the effectiveness of chemotherapeutic drugs used in the treatment of acute myeloid leukemia (AML). This study aimed to investigate whether ROS contributes to cytotoxicity in AML cells when treated with homoharringtonine (HHT) and etoposide (ETP) in combination.

Methods: AML cell lines THP1 and HL60 and primary AML cells from patients were treated with HHT and ETP alone or in combination, and cell viability was determined by trypan blue exclusion test, and apoptosis was analyzed by annexin-V/propidium iodide double staining as well as Western blot for measuring expression of cleaved caspase-9 and cleaved caspase-3. Read More

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http://dx.doi.org/10.2147/CMAR.S187597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349074PMC
January 2019

Implementation of sorafenib treatment for advanced hepatocellular carcinoma: an illustration of current practice in Taiwan.

Cancer Manag Res 2019 22;11:1013-1021. Epub 2019 Jan 22.

Department of General Surgery and Department of Organs Transplantation Institute, Chang G Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan,

Background: Sorafenib is the first regimen listed in the treatment algorithm for hepatocellular carcinoma (HCC) worldwide. This study aimed to assess the efficacy of sorafenib treatment for advanced HCC in a clinical practice using a nationwide population study.

Methods: All patients registered with a diagnosis of primary HCC and identified as having been prescribed sorafenib between August 2012 and December 2015 were selected from a national database and retrospectively reviewed. Read More

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http://dx.doi.org/10.2147/CMAR.S186678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349081PMC
January 2019

Clear cell adenocarcinoma of the lung: a population-based study.

Cancer Manag Res 2019 22;11:1003-1012. Epub 2019 Jan 22.

Department of Radiology, Shanghai Punan Hospital of Pudong New District, Shanghai 200215, China,

Background: Clear cell adenocarcinoma of the lung (CCAL) is a rare diagnosis with poorly understood clinicopathological characteristics and disease progression.

Methods: A population cohort study was conducted using prospectively extracted data from the Surveillance, Epidemiology and End Results database for patients with histological diagnoses of CCAL. Propensity-matched analysis was performed for survival analysis. Read More

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http://dx.doi.org/10.2147/CMAR.S187370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349083PMC
January 2019

Clinical characteristics of extranodal NK/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis.

Cancer Manag Res 2019 23;11:997-1002. Epub 2019 Jan 23.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Background: Extranodal natural killer (NK) / T cell lymphoma is a subtype of non-Hodgkin's lymphoma (NHL) that usually has an aggressive clinical course. It is the predominant trigger of lymphoma-associated hemophagocytic syndrome (LAHS), which is highly lethal and with extremely poor prognosis. This study is aiming to characterize the associated clinical features and prognostic factors of the disease. Read More

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https://www.dovepress.com/clinical-characteristics-of-extran
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http://dx.doi.org/10.2147/CMAR.S183784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350644PMC
January 2019
4 Reads

Transcatheter arterial embolization combined with hypoxia-replicative oncolytic adenovirus perfusion enhances the therapeutic effect of hepatic carcinoma.

Cancer Manag Res 2019 23;11:981-996. Epub 2019 Jan 23.

Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China,

Purpose: Transcatheter arterial embolization or transcatheter arterial chemoembolization has become a critical therapy for unresectable hepatocarcinoma. Although hypoxia caused by embolization can induce apoptosis and necrosis of the majority of tumor cells, a small proportion of cells can survive with hypoxia and chemotherapy resistance. HIF-1α induced by hypoxia is the key factor rendering surviving tumor cells invasive and metastatic properties. Read More

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http://dx.doi.org/10.2147/CMAR.S189208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350642PMC
January 2019

Function of microRNA-145 and mechanisms underlying its role in malignant tumor diagnosis and treatment.

Cancer Manag Res 2019 22;11:969-979. Epub 2019 Jan 22.

Department of Otorhinolaryngology - Head and Neck Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China,

miRNAs are single-stranded small RNAs that do not encode proteins. They can combine complementarily with the 3'-UTRs of target gene mRNA molecules to promote targeted mRNA degradation or inhibit mRNA translation, thereby regulating gene expression at the post-transcriptional level. MiRNAs participate in regulation of cell cycling, growth, apoptosis, differentiation, and stress responses. Read More

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http://dx.doi.org/10.2147/CMAR.S191696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349084PMC
January 2019

Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN.

Cancer Manag Res 2019 22;11:955-968. Epub 2019 Jan 22.

Department of Gastroenterology, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214002, People's Republic of China,

Background: TNF-related apoptosis-inducing ligand (TRAIL) functions as a selective apoptosis-inducing ligand in cancer cells with normal cells remaining unaffected; however, resistance limits its anticancer properties. Cancer stem cells (CSCs) are involved in the treatment of resistant cancer cases including liver cancer (LC). The aim of this study was to look into the approaches for increasing the sensitivity of liver cancer stem cells (LCSCs) toward TRAIL. Read More

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http://dx.doi.org/10.2147/CMAR.S183328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349085PMC
January 2019

Lipase member H is a downstream molecular target of hypoxia inducible factor-1α and promotes papillary thyroid carcinoma cell migration in BCPAP and KTC-1 cell lines.

Cancer Manag Res 2019 22;11:931-941. Epub 2019 Jan 22.

Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China,

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, which is associated with a high incidence of lymph-node metastasis. Multiple biomarkers have been identified for the precise diagnosis of PTC at an early stage. However, their role in PTC remains poorly elucidated. Read More

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http://dx.doi.org/10.2147/CMAR.S183355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349079PMC
January 2019

Feasibility of computer-assisted diagnosis for breast ultrasound: the results of the diagnostic performance of S-detect from a single center in China.

Cancer Manag Res 2019 23;11:921-930. Epub 2019 Jan 23.

Department of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China,

Objective: To investigate the feasibility of a CAD system S-detect on a database from a single Chinese medical center.

Materials And Methods: An experienced radiologist performed breast US examinations and made assessments of 266 consecutive breast lesions in 227 patients. S-detect classified the lesions automatically in a dichotomous form. Read More

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http://dx.doi.org/10.2147/CMAR.S190966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350640PMC
January 2019

Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades.

Cancer Manag Res 2019 21;11:943-953. Epub 2019 Jan 21.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China,

Purpose: This study used the Surveillance, Epidemiology, and End Results (SEER) data to investigate the changes in incidence, treatment, and survival of lung cancer from 1973 to 2015.

Patients And Methods: The clinical and epidemiological data of patients with lung cancer were obtained from the SEER database. Joinpoint regression models were used to estimate the rate changes in lung cancer related to incidence, treatment, and survival. Read More

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http://dx.doi.org/10.2147/CMAR.S187317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345192PMC
January 2019
1 Read

Systemic inflammation response index predicts prognosis in patients with clear cell renal cell carcinoma: a propensity score-matched analysis.

Cancer Manag Res 2019 18;11:909-919. Epub 2019 Jan 18.

Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China,

Purpose: In the present study, we aimed to evaluate the prognostic significance of the systemic inflammation response index (SIRI), which was defined based on peripheral blood counts of neutrophils, lymphocytes, and monocytes, in patients with localized or locally advanced clear cell renal cell carcinoma (CCRCC).

Patients And Methods: The prognostic value of SIRI was evaluated in a primary cohort consisting of 414 patients with localized or locally advanced CCRCC and then further validated in an independent cohort composed of 168 patients.

Results: Kaplan-Meier survival analyses of both cohorts revealed that CCRCC patients with high SIRI levels exhibited poorer overall survival (OS) and cancer-specific survival (CSS) compared with those with low SIRI levels. Read More

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https://www.dovepress.com/systemic-inflammation-response-ind
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http://dx.doi.org/10.2147/CMAR.S186976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342149PMC
January 2019
2 Reads

Outcomes of health-related quality of life after open, laparoscopic, or robot-assisted radical prostatectomy in China.

Cancer Manag Res 2019 18;11:899-907. Epub 2019 Jan 18.

Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China,

Purpose: To compare the outcomes of health-related quality of life (HRQOL) in patients undergoing open (ORP), laparoscopic (LRP), or robot-assisted (RARP) radical prostatectomy.

Patients And Methods: We retrospectively analyzed 347 men with clinically localized prostate cancer treated with ORP (n=97), LRP (n=71), or RARP (n=179) by high-volume surgeons in our institution between January 2014 and December 2016. The primary endpoint was HRQOL including urinary incontinence and erectile dysfunction. Read More

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http://dx.doi.org/10.2147/CMAR.S189893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342140PMC
January 2019
1 Read

Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma.

Cancer Manag Res 2019 17;11:877-897. Epub 2019 Jan 17.

Infectious Department, China-Japan Union Hospital, Jilin University, Changchun 130033, China,

Background: There is evidence that abnormal expression of lncRNAs is associated with hepatitis B virus (HBV) infection-induced hepatocellular carcinoma (HCC). However, the mechanisms remain not fully elucidated. The study aimed to identify novel lncRNAs and explore their underlying mechanisms based on the ceRNA hypothesis. Read More

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https://www.dovepress.com/integrated-analysis-of-lncrna-asso
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http://dx.doi.org/10.2147/CMAR.S186561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340501PMC
January 2019
3 Reads

The novel sugar transporter SLC50A1 as a potential serum-based diagnostic and prognostic biomarker for breast cancer.

Cancer Manag Res 2019 17;11:865-876. Epub 2019 Jan 17.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China,

Background: The novel sugar transporter and membrane protein SLC50A1 has been identified as a potential candidate biomarker for breast cancer; however, its potential as a serum biomarker for breast cancer detection and prognosis is unclear. The aim of this study was to investigate the serum expression profile of SLC50A1 and to determine its diagnostic and prognostic significance in breast cancer.

Materials And Methods: Bioinformatics analysis was conducted, and data for expression in human breast cancer were collected. Read More

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http://dx.doi.org/10.2147/CMAR.S190591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340503PMC
January 2019
2 Reads

Clinicopathological and prognostic significance of hypermethylation in hepatocellular carcinoma: a meta-analysis.

Cancer Manag Res 2019 17;11:857-864. Epub 2019 Jan 17.

Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China,

Background: The patients with hepatocellular carcinoma (HCC) have poor prognosis due to being diagnosed at late stage or recurrence following surgery. It's critical to identify effective biomarkers that can improve overall diagnosis and treatment of HCC.

Methods: We performed a meta-analysis of all relative studies reporting the clinicopathological significance of hypermethylation in HCC by using Review Manager 5. Read More

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http://dx.doi.org/10.2147/CMAR.S179710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340500PMC
January 2019

TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.

Cancer Manag Res 2019 17;11:839-855. Epub 2019 Jan 17.

Department of Obstetrics and Gynaecology, Shengjing Hospital Affiliated to China Medical University, Liaoning, China,

Background: Transmembrane protein with epidermal growth factor-like and two follistatin-like domains 1 (TMEFF1) has an anticarcinogenic effect in brain tumors. However, little is known about the role of TMEFF1 in epithelial ovarian cancer (EOC).

Materials And Methods: TMEFF1 expression in EOC was detected by immunohistochemistry; its relationship with clinical pathological parameters and its influence on prognosis were analyzed. Read More

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https://www.dovepress.com/tmeff1-overexpression-and-its-mech
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http://dx.doi.org/10.2147/CMAR.S186080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340504PMC
January 2019
5 Reads

High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis.

Cancer Manag Res 2019 17;11:831-837. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China,

Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).

Patients And Methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated. Read More

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http://dx.doi.org/10.2147/CMAR.S187849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340498PMC
January 2019
2 Reads

PUF60 accelerates the progression of breast cancer through downregulation of PTEN expression.

Cancer Manag Res 2019 17;11:821-830. Epub 2019 Jan 17.

Department of Medical Imaging, Henan University First Affiliated Hospital, Kaifeng, Henan, China,

Background: PUF60 is a splicing variant of far upstream element binding protein 1-interacting repressor, which is abnormally expressed in a variety of tumors and is closely involved in their progression. However, whether PUF60 participates in the occurrence and development of breast cancer remains unknown. Therefore, the objective of the current study is to explore the effects and mechanism of PUF60 in the progression of breast cancer. Read More

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https://www.dovepress.com/puf60-accelerates-the-progression-
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http://dx.doi.org/10.2147/CMAR.S180242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340502PMC
January 2019
2 Reads

Systemic immune-inflammation index and ultrasonographic classification of breast imaging-reporting and data system predict outcomes of triple-negative breast cancer.

Cancer Manag Res 2019 17;11:813-819. Epub 2019 Jan 17.

Department of Ultrasound, Dongguan People's Hospital, Dongguan, Guangdong 523000, China,

Introduction: This research was conducted to explore the relationship between the systemic immune-inflammation index (SII) and breast imaging-reporting and data system (BI-RADS) classification using ultrasonography and the survival of patients with triple-negative breast cancer (TNBC) in a cohort of Chinese.

Methods: A total of 215 TNBC patients treated at our hospital between November 2008 and March 2016 were enrolled in this study. We used the log-rank test and Kaplan-Meier curves to assess the overall survival (OS) and disease-free survival (DFS) differences between groups. Read More

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http://dx.doi.org/10.2147/CMAR.S185890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340637PMC
January 2019

MNX1-AS1 is a functional oncogene that induces EMT and activates the AKT/mTOR pathway and MNX1 in breast cancer.

Cancer Manag Res 2019 17;11:803-812. Epub 2019 Jan 17.

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China,

Purpose: lncRNAs have recently been identified as key regulators of basic biological processes as well as the pathogenesis of various diseases. Previous studies have shown that lncRNA MNX1-AS1 promotes cell migration and invasion in ovarian cancer; however, its role in regulating breast cancer-associated biological processes remains unclear.

Materials And Methods: We obtained paired specimens of breast cancer tissues and adjacent normal tissues by modified radical mastectomy from 36 patients, in addition to four breast cancer cell lines (MDA-MB-231, MDA-MB-468, BT-549 and MCF-7). Read More

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http://dx.doi.org/10.2147/CMAR.S188007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340505PMC
January 2019

Outcome and prognostic factors following palliative craniospinal irradiation for leptomeningeal carcinomatosis.

Cancer Manag Res 2019 17;11:789-801. Epub 2019 Jan 17.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg 69120, Germany,

Background: Leptomeningeal carcinomatosis (LC) is a severe complication of metastatic tumor spread to the central nervous system. Prognosis is dismal with a median overall survival (OS) of ~10-15 weeks. Treatment options include radiotherapy (RT) to involved sites, systemic chemo- or targeted therapy, intrathecal chemotherapy and best supportive care with dexamethasone. Read More

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http://dx.doi.org/10.2147/CMAR.S182154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340499PMC
January 2019
1 Read

Dysregulation of ncRNAs located at the DLK1‑DIO3 imprinted domain: involvement in urological cancers.

Cancer Manag Res 2019 15;11:777-787. Epub 2019 Jan 15.

Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China,

Genomic imprinting has been found to be involved in human physical development and several diseases. The imprinted domain is located on human chromosome 14 and contains paternally expressed protein-coding genes () and numerous maternally expressed ncRNA genes (, , miRNAs, piRNAs, and snoRNAs). Emerging evidence has implicated that dysregulation of the imprinted domain especially the imprinted ncRNAs is critical for tumor progressions. Read More

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http://dx.doi.org/10.2147/CMAR.S190764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339654PMC
January 2019

TINAGL1 promotes hepatocellular carcinogenesis through the activation of TGF-β signaling-medicated VEGF expression.

Cancer Manag Res 2019 15;11:767-775. Epub 2019 Jan 15.

Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China,

Background And Purpose: Tubulointerstitial nephritis antigen-like 1 (TINAGL1) is an extracellular matrix protein that plays an important role in cell adhesion and therefore modulates cell proliferation, migration, and differentiation. In addition, it is frequently upregulated in highly metastatic tumors. The aim of our study was to determine the role of TINAGL1 in the progression and metastasis of hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.2147/CMAR.S190390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339651PMC
January 2019

Determining the optimal cutoff point for lymph node density and its impact on overall survival in children with Wilms' tumor.

Cancer Manag Res 2019 15;11:759-766. Epub 2019 Jan 15.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China,

Objective: Previous studies showed that the lymph node density (LND) was a predictor of survival in Wilms' tumor (WT). However, the optimal LND cutoff point is controversial due to methodological shortcomings of previous studies, and no studies have shown the effect of LND on survival in children with WT. The purpose of this study was to remedy this situation. Read More

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http://dx.doi.org/10.2147/CMAR.S190138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339645PMC
January 2019

Neoadjuvant chemoradiation for locally advanced rectal cancer: a systematic review of the literature with network meta-analysis.

Cancer Manag Res 2019 15;11:741-758. Epub 2019 Jan 15.

Department of General Surgery, Xiamen Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Xiamen 361009, China,

Background: Neoadjuvant chemoradiotherapy (CRT) prior to surgery is a standard therapy for locally advanced rectal cancer, but the optimum regime is not conclusive. This meta-analysis evaluated various CRT regimens with regard to the rate of pathologic complete response (pCR) and toxic effects of grade ≥3.

Methods: The databases PubMed, Cochrane Library, and Embase were searched for randomized controlled trials (RCTs) that compared neoadjuvant CRT regimes for treating patients with locally advanced rectal cancer, published before 28 December 2017. Read More

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http://dx.doi.org/10.2147/CMAR.S189445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339644PMC
January 2019

Comparative study of adjuvant chemotherapeutic efficacy of docetaxel plus cyclophosphamide and doxorubicin plus cyclophosphamide in female breast cancer.

Cancer Manag Res 2019 15;11:727-739. Epub 2019 Jan 15.

Oncology Department, Faisalabad Medical University, Allied Hospital, Faisalabad, Punjab, Pakistan.

Purpose: This retrospective study presents a comparative analysis of the overall survival and toxicities, as side effects, of docetaxel plus cyclophosphamide (TC) and doxorubicin plus cyclophosphamide (AC). The study measured their efficacies during adjuvant chemotherapy, treating Pakistani breast cancer patients by validating the results obtained, with the published analysis of the same treatment given to US patients.

Patients And Methods: Between June 2015 and September 2017, for four chemotherapy cycles, 189 patients out of 358 received TC (75 mg/m of docetaxel, 600 mg/m of cyclophosphamide) and 169 were treated with AC (60 mg/m of doxorubicin, 600 mg/m of cyclophosphamide). Read More

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http://dx.doi.org/10.2147/CMAR.S180802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339652PMC
January 2019

Erratum: -saponins are natural inhibitors of AKT, MCL-1, and BCL2L1 in cervical cancer cells [Corrigendum].

Authors:

Cancer Manag Res 2019 15;11:691. Epub 2019 Jan 15.

[This corrects the article on p. 5709 in vol. 10, PMID: 30532593. Read More

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http://dx.doi.org/10.2147/CMAR.S198251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339639PMC
January 2019

Aberrant CEACAM19 expression is associated with metastatic phenotype in penile cancer.

Cancer Manag Res 2019 14;11:715-725. Epub 2019 Jan 14.

Laboratory of Oncology Research, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Human 410008, P.R. China,

Objective: A greater knowledge of the mechanisms of the pathogenesis of penile cancers may assist in the development of more tailored targeted therapy. Herein, we aimed to evaluate the expression of CEACAM19 in penile cancer and to explore its regulatory mechanisms.

Material And Methods: This retrospective study enrolled 64 penile cancer patients who underwent penectomy between 2011 and 2015. Read More

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http://dx.doi.org/10.2147/CMAR.S192385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338120PMC
January 2019
2 Reads

Type 2 diabetes mellitus increases the risk of hepatocellular carcinoma in subjects with chronic hepatitis B virus infection: a meta-analysis and systematic review.

Cancer Manag Res 2019 14;11:705-713. Epub 2019 Jan 14.

Liver Transplantation Center, Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China,

Background: Type 2 diabetes mellitus has been proved to be a risk factor of hepatocellular carcinoma, but how diabetes affects incidence of hepatocellular carcinoma among patients with chronic hepatitis B virus infection remains controversial.

Methods: A comprehensive search of Medline and Embase was performed. Incidence of hepatocellular carcinoma in chronic hepatitis B patients was the primary outcome. Read More

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https://www.dovepress.com/type-2-diabetes-mellitus-increases
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http://dx.doi.org/10.2147/CMAR.S188238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338123PMC
January 2019
3 Reads

A sample model established by S-index predicting overall survival after curative resection of primary hepatocellular carcinoma.

Cancer Manag Res 2019 14;11:693-703. Epub 2019 Jan 14.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou, China,

Purpose: Prognostic prediction after curative resection of primary hepatocellular carcinoma (PHCC) remains an arduous task. The S-index calculated from γ-glutamyl transpeptidase, albumin, and platelets is reported to predict the severity of liver fibrosis. We constructed a nomogram for predicting the survival probability of PHCC based on a new indicator, the S-index, combined with other routine clinical parameters. Read More

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http://dx.doi.org/10.2147/CMAR.S193593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338126PMC
January 2019
1 Read

Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3β-mediated c-FLIP degradation in non-small cell lung cancer.

Cancer Manag Res 2019 11;11:681-689. Epub 2019 Jan 11.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, People's Republic of China,

Background: Metformin, a first-line antidiabetic drug, has recently been reported with anticancer activities in various cancers; however, the underlying mechanisms remain elusive. The aim of the present study was to investigate the role of cellular FADD-like IL-1β-converting enzyme (FLICE)-inhibitory protein large (c-FLIP) in metformin-induced anticancer activity in non-small cell lung cancer (NSCLC) in vitro.

Materials And Methods: Cell viability was measured by MTT assay. Read More

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https://www.dovepress.com/metformin-induces-apoptotic-cytoto
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http://dx.doi.org/10.2147/CMAR.S178688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331071PMC
January 2019
3 Reads

Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis.

Cancer Manag Res 2019 11;11:669-680. Epub 2019 Jan 11.

Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China,

Background: Giant cell tumor of bone (GCTB) is a locally aggressive tumor, and its postoperative recurrence remains a problem. The present meta-analysis aimed to analyze the effect of bisphosphonates (BPs) on local recurrence of GCTB.

Methods: Seven case-control studies were included by computerized searches of bibliographic databases (PubMed, AMED, EMBASE, the Cochrane library, ISI Web of Science, and China National Knowledge Infrastructure). Read More

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http://dx.doi.org/10.2147/CMAR.S187316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331072PMC
January 2019

lncRNA WT1-AS inhibits the aggressiveness of cervical cancer cell via regulating p53 expression via sponging miR-330-5p.

Cancer Manag Res 2019 11;11:651-667. Epub 2019 Jan 11.

Department of Gynecology, Jiaozuo Maternal and Child Care Service Center, Jiaozuo, Henan Province, China.

Background: Emerging evidences have demonstrated that lncRNAs play vital roles in various pathological processes, including cancer. The lncRNA WT1 antisense RNA (WT1-AS) serves as a tumor suppressor in various cancers. Nevertheless, the expression and precise function of WT1-AS in cervical carcinoma still remain not yet investigated. Read More

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https://www.dovepress.com/lncrna-wt1-as-inhibits-the-aggress
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http://dx.doi.org/10.2147/CMAR.S176525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331070PMC
January 2019
2 Reads

MicroRNA-4458 suppresses migration and epithelial-mesenchymal transition via targeting HMGA1 in non-small-cell lung cancer cells.

Cancer Manag Res 2019 10;11:637-649. Epub 2019 Jan 10.

Department of Nuclear Medicine, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China,

Purpose: Increasing studies have shown that microRNA-4458 (miR-4458) is associated with human cancer progression. However, the molecular mechanism of miR-4458 in non-small-cell lung cancer (NSCLC) remains largely unknown. This study aims to reveal the biological function of miR-4458 in NSCLC. Read More

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http://dx.doi.org/10.2147/CMAR.S185117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331073PMC
January 2019

Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3β/p53 activation.

Cancer Manag Res 2019 10;11:625-636. Epub 2019 Jan 10.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China,

Background: Adriamycin (ADR) is widely used in the clinical chemotherapy against breast cancer. But its efficacy is strongly limited due to the acquisition of multidrug resistance (MDR). Therefore, acquisition of the resistance to ADR is still a major cause of chemotherapy failure in breast cancer patients. Read More

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http://dx.doi.org/10.2147/CMAR.S191353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331075PMC
January 2019