Search our Database of Scientific Publications and Authors

I’m looking for a

    378 results match your criteria Cancer Management and Research [Journal]

    1 OF 8

    Uncemented three-dimensional-printed prosthetic replacement for giant cell tumor of distal radius: a new design of prosthesis and surgical techniques.
    Cancer Manag Res 2018 8;10:265-277. Epub 2018 Feb 8.
    Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Introduction: Currently, it is challenging to treat giant cell tumor (GCT) of distal radius. For Campanacci grade III or recurrent GCTs, en bloc resection has been accepted as a better treatment option. Although numerous methods are available for reconstruction, all of them have some limitations in joint function and complications. Read More

    Anastomotic reinforcement with omentoplasty reduces anastomotic leakage for minimally invasive esophagectomy with cervical anastomosis.
    Cancer Manag Res 2018 7;10:257-263. Epub 2018 Feb 7.
    Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China.
    Purpose: Anastomotic leakage is the most feared postoperative complication after esophagectomy. Omentoplasty, wrapping the omentum around the alimentary tract anastomosis, is thought to decrease the anastomotic leakage rate. The purpose of this clinical study is to investigate the use of omentoplasty to reinforce cervical esophagogastrostomy after minimally invasive esophagectomy (MIE). Read More

    Comparative effectiveness of early-line-paclitaxel vs. paclitaxel in patients with metastatic breast cancer: a US community-based real-world analysis.
    Cancer Manag Res 2018 8;10:249-256. Epub 2018 Feb 8.
    Department of Hematology/Oncology, University of Nevada School of Medicine, Las Vegas, NV.
    Background: Real-world analyses of treatments for patients with metastatic breast cancer are limited. We evaluated the comparative effectiveness of-paclitaxel vs. paclitaxel in patients with metastatic breast cancer using data from an electronic medical record database from community practices across the USA. Read More

    Gastric cancer: epidemiology, prevention, classification, and treatment.
    Cancer Manag Res 2018 7;10:239-248. Epub 2018 Feb 7.
    Department of Surgical Oncology, Medical University of Lublin, Lublin, Poland.
    Gastric cancer is the second most common cause of cancer-related deaths in the world, the epidemiology of which has changed within last decades. A trend of steady decline in gastric cancer incidence rates is the effect of the increased standards of hygiene, conscious nutrition, anderadication, which together constitute primary prevention. Avoidance of gastric cancer remains a priority. Read More

    Comparison of prognostic prediction between nomogram based on lymph node ratio and AJCC 8th staging system for patients with resected pancreatic head carcinoma: a SEER analysis.
    Cancer Manag Res 2018 5;10:227-238. Epub 2018 Feb 5.
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
    Background: The prognosis of pancreatic carcinoma (PC) remains poor and the American Joint Committee on Cancer (AJCC) 8th staging system for survival prediction in PC patients after curative resection is still limited. Thus, the aim of this study is to refine a valuable prognostic model and novel staging system for PC with curative resection.

    Methods: The data of 3,458 patients used in this study were retrieved from the Surveillance, Epidemiology, and End Results database registry of National Cancer Institute. Read More

    Influential factors on radiotherapy efficacy and prognosis in patients with secondary lymph node metastasis after esophagectomy of thoracic esophageal squamous cell carcinoma.
    Cancer Manag Res 2018 2;10:217-225. Epub 2018 Feb 2.
    Department of Radiotherapy and Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, People's Republic of China.
    Background: The purpose of this study was to clarify whether pretreatment tumor burden-related index, including the gross tumor volume (GTV) of metastatic lymph nodes (V) and maximum diameter of metastatic lymph nodes (D), and inflammatory markers, consisting of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), are useful for assessing the therapeutic effects and prognosis with secondary lymph node metastasis (LNM) receiving chemoradiotherapy (CRT) or radiotherapy (RT) alone after resection of esophageal squamous cell carcinoma (ESCC).

    Patients And Methods: A total of 119 patients with secondary LNM after resection of ESCC were recruited and received curative RT only or CRT. The enrolled patients were grouped according to the median values of NLR, PLR, V, and D. Read More

    Advances in the treatment of soft tissue sarcoma: focus on eribulin.
    Cancer Manag Res 2018 1;10:207-216. Epub 2018 Feb 1.
    Royal Marsden Hospital, London, UK.
    Eribulin mesylate is a synthetic derivative of halichondrin B isolated from a marine sponge. Its mechanism of action is through microtubule inhibition, which is different from that of taxanes. Eribulin has been approved for the treatment of metastatic breast cancer and more recently for non-operable or metastatic liposarcoma in patients who have received prior anthracycline chemotherapy. Read More

    Role of intestinal flora in colorectal cancer from the metabolite perspective: a systematic review.
    Cancer Manag Res 2018 31;10:199-206. Epub 2018 Jan 31.
    Department of Intervention and Radiotherapy, Huzhou Central Hospital, Huzhou, Zhejiang Province, People's Republic of China.
    Colorectal cancer is one of the most common human malignant tumors. Recent research has shown that colorectal cancer is a dysbacteriosis-induced disease; however, the role of intestinal bacteria in colorectal cancer is unclear. This review explores the role of intestinal flora in colorectal cancer. Read More

    Early diagnostic potential ofhypermethylation in esophageal cancer.
    Cancer Manag Res 2018 1;10:181-198. Epub 2018 Feb 1.
    Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
    Background: The hypermethylation of APC gene is observed in various cancers, including esophageal cancer (EC). However, the association between APC methylation and the initiation and progression of EC is poorly understood.

    Purpose And Methods: The current study systematically reviewed studies on abnormal methylation of APC in EC and quantitatively synthesized 18 studies by meta-analysis involving 1008 ECs, 570 Barrett's esophagus (BE), and 782 controls. Read More

    Adrenal myelolipoma with hyperandrogenemia and schizophrenia.
    Cancer Manag Res 2018 1;10:177-180. Epub 2018 Feb 1.
    Department of Urology, Peking University Third Hospital, Beijing, China.
    Adrenal myelolipoma with hyperandrogenemia is extremely rare. We report a case of a 26-year-old Chinese female with schizophrenia, who presented with a hormonally active tumor causing hyperandrogenemia. The mass was found by computerized tomography when she had her gynecologic examination for secondary amenorrhea, and it was confirmed to be an adrenal myelolipoma after a histopathological study. Read More

    Treatment and outcomes of non-small-cell lung cancer patients with high comorbidity.
    Cancer Manag Res 2018 24;10:167-175. Epub 2018 Jan 24.
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY.
    Background: The life expectancy of untreated non-small-cell lung cancer (NSCLC) is dismal, while treatment for NSCLC improves survival. The presence of comorbidities is thought to play a significant role in the decision to treat or not treat a given patient. We aim to evaluate the association of comorbidities with the survival of patients treated for NSCLC. Read More

    Solute carrier transporters: potential targets for digestive system neoplasms.
    Cancer Manag Res 2018 24;10:153-166. Epub 2018 Jan 24.
    Department of Integrative Oncology, Fudan University Shanghai Cancer Center.
    Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues of digestive systems and mediate specific uptake of small molecule substrates in facilitative manner. Given the important role of SLC proteins in maintaining normal functions of digestive system, dysregulation of these protein in digestive system neoplasms may deliver biological and clinical significance that deserves systemic studies. Read More

    Association between body mass index and breast cancer risk: evidence based on a dose-response meta-analysis.
    Cancer Manag Res 2018 18;10:143-151. Epub 2018 Jan 18.
    Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University.
    Introduction: Breast cancer is the most common cancer in women worldwide. The association between body mass index (BMI) and breast cancer risk has been paid more attention in the past few years, but the findings are still controversial. To obtain a more reliable conclusion, we performed a dose-response meta-analysis on 12 prospective cohort studies comprising 22,728,674 participants. Read More

    Radiation-induced secondary malignancies for nasopharyngeal carcinoma: a pilot study of patients treated via IMRT or VMAT.
    Cancer Manag Res 2018 18;10:131-141. Epub 2018 Jan 18.
    Medical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan, Republic of China.
    Background: Patients treated with radiotherapy are at risk of developing a second cancer during their lifetime, which can directly impact treatment decision-making and patient management. The aim of this study was to qualify and compare the secondary cancer risk (SCR) after intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in nasopharyngeal carcinoma (NPC) patients.

    Patients And Methods: We analyzed the treatment plans of a cohort of 10 NPC patients originally treated with IMRT or VMAT. Read More

    The role of brigatinib in crizotinib-resistant non-small cell lung cancer.
    Cancer Manag Res 2018 18;10:123-130. Epub 2018 Jan 18.
    Medical Oncology Department, Gustave Roussy, Villejuif, France.
    Despite the advances in new targeted therapies in ALK positive population, most patients progress under ALK inhibitors within first 2 years; being the brain the most frequent site of relapse. ALK mutations, in ~30% of patients, are the main known mechanism of resistance. Classically, second-generation ALK inhibitors have been the standard of care in the crizotinib-resistant population; however, each ALK inhibitor has a different spectrum of sensitivity to ALK mutations, complicating the optimal treatment strategy for the resistant population. Read More

    A comparison of QuantStudio™ 3D Digital PCR and ARMS-PCR for measuring plasma EGFR T790M mutations of NSCLC patients.
    Cancer Manag Res 2018 18;10:115-121. Epub 2018 Jan 18.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Oncology II, Peking University Cancer Hospital & Institute, Beijing, China.
    Background: The AURA3 clinical trial has shown that advanced non-small cell lung cancer (NSCLC) patients with EGFR T790M mutations in circulating tumor DNA (ctDNA) could benefit from osimertinib.

    Purpose: The aim of this study was to assess the usefulness of QuantStudio™ 3D Digital PCR System platform for the detection of plasma EGFR T790M mutations in NSCLC patients, and compare the performances of 3D Digital PCR and ARMS-PCR.

    Patients And Methods: A total of 119 Chinese patients were enrolled in this study. Read More

    The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance.
    Cancer Manag Res 2018 18;10:105-113. Epub 2018 Jan 18.
    Clinical Laboratory Center, The First Affiliated Hospital of Xinjiang Medical University.
    Background: According to recent clinical observations, deficient DNA mismatch repair (dMMR) is capable of improving antitumor effects of the PD-1/PD-L1 pathway, suggesting that dMMR may act as a prognostic indicator of PD-1/PD-L1 antibody drugs. In this study, we examined the dMMR and PD-1/PD-L1 expression, as well as explored the correlation of dMMR status with PD-1/PD-L1 expression in cervical cancer patients, in order to optimize cervical cancer patient selection for PD-1/PD-L1 antibody drug treatment, which is helpful to avoid adverse effects and keep costs manageable.

    Methods: Sixty-six tissue samples from patients with squamous cell carcinoma were collected, and data of their clinical characteristics were also gathered. Read More

    Neoadjuvant treatments in triple-negative breast cancer patients: where we are now and where we are going.
    Cancer Manag Res 2018 15;10:91-103. Epub 2018 Jan 15.
    Department of Medical and Surgical Sciences for Children & Adults, Division of Medical Oncology, University Hospital of Modena, Modena, Italy.
    Triple-negative breast cancer (TNBC) remains the poorest-prognosis breast cancer (BC) subtype. Gene expression profiling has identified at least six different triple-negative subtypes with different biology and sensitivity to therapies. The heterogeneous nature of TN tumors may justify the difficulty in treating this BC subtype. Read More

    The potential role of angiogenesis in the development of shoulder pain, shoulder dysfunction, and lymphedema after breast cancer treatment.
    Cancer Manag Res 2018 15;10:81-90. Epub 2018 Jan 15.
    Clinical Research Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
    Shoulder morbidity is a well-documented sequela of breast cancer treatment, which includes various manifestations such as pain, reduced range of motion, and lymphedema, among others. The multifactorial nature of such morbidities has long been appreciated, and research on reliable risk predictors of development thereof still continues. Previous studies have demonstrated the potential of different types of physical therapy to treat such shoulder problems, and the integration of such interventions into routine care for breast cancer survivors is a requirement in most high-income countries. Read More

    Toxic elements as biomarkers for breast cancer: a meta-analysis study.
    Cancer Manag Res 2018 10;10:69-79. Epub 2018 Jan 10.
    Department of Medical Surgical, Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran.
    Aims And Background: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors for BC. Read More

    Vulvar carcinoma: dilemma, debates, and decisions.
    Cancer Manag Res 2018 9;10:61-68. Epub 2018 Jan 9.
    Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.
    Vulvar carcinoma is a rare and aggressive gynecological malignancy. It affects elderly females, with the mean age at diagnosis being 55-60 years. Regional metastasis to inguinal lymph nodes is common. Read More

    Detection of circulating tumor cells in liquid biopsy from Ewing sarcoma patients.
    Cancer Manag Res 2018 9;10:49-60. Epub 2018 Jan 9.
    Department of Chemotherapy, Rizzoli Institute, Bologna, Italy.
    Background: Circulating tumor cells (CTCs) analysis is a promising new diagnostic field to estimate risk and monitor treatment efficacy, metastatic relapse, and progression in cancer patients. The study aim was to isolate and characterize CTCs in blood samples of Ewing sarcoma (ES) patients exploiting two main characteristics: CD99 expression and presence of chromosomal translocations.

    Materials And Methods: The method isolated CTCs from peripheral blood (PB) of ES patients. Read More

    Young age increases risk for lymph node positivity but decreases risk for non-small cell lung cancer death.
    Cancer Manag Res 2018 8;10:41-48. Epub 2018 Jan 8.
    Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province.
    Non-small cell lung cancer (NSCLC) prognosis and risk of lymph node positivity (LN+) are reference points for reasonable treatments. The aim of the current study was to investigate the effect of age on LN+ and NSCLC death. Data from the Surveillance, Epidemiology, and End Results (SEER) registry were used to identify 82,253 patients with NSCLC diagnosed between 1988 and 2008. Read More

    The reciprocal relationship between coping mechanisms and lung cancer diagnosis: findings of a prospective study.
    Cancer Manag Res 2018 4;10:33-40. Epub 2018 Jan 4.
    Department of Surgical Semiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
    Background/purpose: Lung cancer is a major stress factor for the affected individual, leading to psychological distress in over 50% of the diagnosed patients. Since coping styles describe different patterns in approaching serious problems, our study aimed at ascertaining if the diagnosis of lung cancer has an impact on the patient's coping styles and if there is a difference in psychical response among patients with different coping styles, as assessed by variance of anxiety and depression scores after diagnosis.

    Patients And Methods: In this prospective study, a cohort of 50 patients were evaluated using the COPE scale, Generalized Anxiety Disorder Questionnaire 7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9), both prior to and 1 month after learning about their lung cancer diagnosis. Read More

    Effects of marital status on survival of hepatocellular carcinoma by race/ethnicity and gender.
    Cancer Manag Res 2018 3;10:23-32. Epub 2018 Jan 3.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University.
    Purpose: It is well demonstrated that being married is associated with a better prognosis in multiple types of cancer. However, whether the protective effect of marital status varied across race/ethnicity and gender in patients with hepatocellular carcinoma remains unclear. Therefore, we aimed to evaluate the roles of race/ethnicity and gender in this relationship. Read More

    Radiotherapy for esophageal carcinoma: dose, response and survival.
    Cancer Manag Res 2018 29;10:13-21. Epub 2017 Dec 29.
    Department of Radiation Oncology and Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
    Esophageal cancer (EC) is an extremely aggressive, lethal malignancy that is increasing in incidence worldwide. At present, definitive chemoradiotherapy is accepted as the standard treatment for locally advanced EC. The EC guidelines recommend a radiation dose of 50. Read More

    Programmed death-ligand 1 expression correlates with diminished CD8+ T cell infiltration and predicts poor prognosis in anal squamous cell carcinoma patients.
    Cancer Manag Res 2018 18;10:1-11. Epub 2017 Dec 18.
    Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center.
    Objective: Increased expression of programmed death-ligand 1 (PD-L1) on tumor cells can be found in various malignancies; however, very limited information is known about its role in anal squamous cell carcinoma (ASCC). This study explored PD-L1 expression in ASCC patients and its association with patients' clinicopathological features, CD8+ T cell infiltration, and prognosis.

    Methods: Formalin-fixed paraffin-embedded tumor samples from 26 patients with ASCC were retrieved. Read More

    Clinical significance of miR-34a expression in thyroid diseases - anF-FDG PET-CT study.
    Cancer Manag Res 2017 15;9:903-913. Epub 2017 Dec 15.
    Department of PET/CT Center.
    Purpose: To evaluate the possible roles of miR-34a expression in thyroid lesions, to unravel the correlation between fluorodeoxyglucose (FDG) uptake and miR-34a expression and moreover, to discover the underlying mechanisms by which miR-34a regulates FDG avidity.

    Methods: We retrospectively reviewed 75 patients with pathology-confirmed thyroid diseases who underwentF-FDG positron emission tomography/computed tomography (PET/CT) within 3 months before undergoing thyroid surgery and miR-34a analysis from June 2012 to July 2017.F-FDG uptake of thyroid lesions was also analyzed semiquantitatively using maximum standardized uptake value (SUVmax). Read More

    Expression profile analysis of long noncoding RNA in ER-positive subtype breast cancer using microarray technique and bioinformatics.
    Cancer Manag Res 2017 14;9:891-901. Epub 2017 Dec 14.
    Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
    Background: The estrogen receptor (ER)-positive subtype of breast cancer (BC) is the most common type of BC. A number of long noncoding RNAs (lncRNAs) play critical roles in cancer biology, including BC. Previous lncRNA profiling studies have focused only on triple-negative BC and HER 2-positive BC, and no studies have specifically focused on lncRNAs in ER-positive BC. Read More

    ZNF259 inhibits non-small cell lung cancer cells proliferation and invasion by FAK-AKT signaling.
    Cancer Manag Res 2017 14;9:879-889. Epub 2017 Dec 14.
    Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.
    Background: Zinc finger protein 259 (ZNF259) is known to play essential roles in embryonic development and cell cycle regulation. However, its expression pattern and clinicopathological relevance remain unclear.

    Materials And Methods: A total of 114 lung cancer specimens were collected. Read More

    Systemic immune-inflammation index as a useful prognostic indicator predicts survival in patients with advanced gastric cancer treated with neoadjuvant chemotherapy.
    Cancer Manag Res 2017 14;9:849-867. Epub 2017 Dec 14.
    Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang.
    Background And Objective: A novel systemic immune-inflammation index named SII (SII=N×P/L), which is based on neutrophil (N), platelet (P) and lymphocyte (L) counts, has emerged and reflects comprehensively the balance of host inflammatory and immune status. We aimed to evaluate the potential prognostic significance of SII in patients with advanced gastric cancer who received neoadjuvant chemotherapy.

    Subjects And Methods: The retrospective analysis included data from 107 patients with advanced gastric cancer undergoing neoadjuvant chemotherapy and 185 patients with pathology-proven gastric cancer. Read More

    Observation of different tumor motion magnitude within liver and estimate of internal motion margins in postoperative patients with hepatocellular carcinoma.
    Cancer Manag Res 2017 12;9:839-848. Epub 2017 Dec 12.
    Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
    Aims: To assess motion magnitude in different parts of the liver through surgical clips in postoperative patients with hepatocellular carcinoma and to examine the correlation between the clip and diaphragm motion.

    Methods: Four-dimensional computed tomography images from 30 liver cancer patients under thermoplastic mask immobilization were selected for this study. Three to seven surgical clips were placed in the resection cavity of each patient. Read More

    Prognostic role and clinical significance of trophoblast cell surface antigen 2 in various carcinomas.
    Cancer Manag Res 2017 12;9:821-837. Epub 2017 Dec 12.
    Department of Oncology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
    Introduction: Trophoblast cell surface antigen 2 (TROP2) has been linked to disease prognosis in various human cancers and plays a critical role in tumor development, progression, and metastasis. A number of relevant studies have been published on this topic. A meta-analysis of the latest literature to evaluate the value of TROP2 as a predictive prognosticator of cancer was performed. Read More

    Comparison of survival outcomes between radical hysterectomy and definitive radiochemotherapy in stage IB1 and IIA1 cervical cancer.
    Cancer Manag Res 2017 11;9:813-819. Epub 2017 Dec 11.
    Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.
    Introduction: There is an ongoing debate regarding the optimal local treatment modalities for stage IB1 and IIA1 cervical cancer. The aim of this study was to determine whether radical hysterectomy or definitive radiochemotherapy is superior in stage IB1 and IIA1 cervical squamous cell carcinoma (SCC).

    Methods: From 1990 to 2010, a total of 3,769 patients with stage IB1 and IIA1 cervical SCC were included from the Surveillance, Epidemiology, and End Results database and were stratified according to whether they received radical hysterectomy or primary radiochemotherapy. Read More

    Neoadjuvant chemotherapy followed by fast-track cytoreductive surgery plus short-course hyperthermic intraperitoneal chemotherapy (HIPEC) in advanced ovarian cancer: preliminary results of a promising all-in-one approach.
    Cancer Manag Res 2017 13;9:869-878. Epub 2017 Dec 13.
    Department of Surgery, IMIP - Instituto de Medicina Integral Professor Fernando Figueira, Recife, Brazil.
    Purpose: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been considered a promising treatment option for advanced or recurrent ovarian cancer, but there is no clear evidence based on randomized controlled trials to advocate this approach as a standard therapy. In this study, we aim to present the early outcomes and insights after an interim analysis of a pioneering clinical trial in Brazil.

    Methods: This study was a cross-sectional analysis of early data from our ongoing clinical trial - an open-label, double-center, single-arm trial on the safety and efficacy of using HIPEC for advanced ovarian cancer (ClinicalTrials. Read More

    The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor.
    Cancer Manag Res 2017 7;9:801-811. Epub 2017 Dec 7.
    Department of Respiratory, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
    With the clinical promotion of precision medicine and individualized medical care, molecular targeted medicine has been used to treat non-small cell lung cancer (NSCLC) patients and proved to be significantly effective. Anaplastic lymphoma kinase (ALK) inhibitor is one of the most important specific therapeutic agents for patients with ALK-positive NSCLC. It can extend the survival of patients. Read More

    Economic burden of the management of metastatic castrate-resistant prostate cancer in Italy: a cost of illness study.
    Cancer Manag Res 2017 7;9:789-800. Epub 2017 Dec 7.
    Nuclear Medicine Department, Cliniche Humanitas Gavazzeni, Bergamo, Italy.
    Background: Prostate cancer (PCa) accounts for 20% of all cancers in subjects over 50 years in Italy. The majority of patients with PCa present with localized disease at the time of diagnosis, but many patients develop recurrent metastatic disease after treatment with curative intent. Androgen deprivation therapy is the standard of care for metastatic PCa patients; unfortunately, most of them progress to castrate-resistant prostate cancer (CRPC) within 5 years. Read More

    Low expression of GATA3 promotes cell proliferation and metastasis in gastric cancer.
    Cancer Manag Res 2017 7;9:769-780. Epub 2017 Dec 7.
    School of Life Science, Shanghai University, Shanghai, People's Republic of China.
    GATA3, a member of the GATA zinc finger transcription factor family, has been widely investigated for its role in cancer. Although a recent report has found that GATA3 is downregulated in gastric cancer (GC), the detailed mechanism of GATA3 in GC is still unknown. Here, we investigated whether GATA3 was downregulated in GC patients' tissue samples and cell lines using quantitative real time polymerase chain reaction and Western blotting. Read More

    CanF-FDG PET predict the grade of malignancy in thymic epithelial tumors? An evaluation of only resected tumors.
    Cancer Manag Res 2017 5;9:761-768. Epub 2017 Dec 5.
    Department of Nuclear Medicine, Cancer Institute Hospital, Tokyo, Japan.
    Objective: Although 18-fluorine fluorodeoxyglucose positron emission tomography (F-FDG PET) is thought to be useful for predicting the histological grade of thymic epithelial tumors (TETs), it remains controversial. To date, just a few of many previous studies have included only resected cases. Therefore, we investigatedF-FDG PET findings only in patients with resected TETs. Read More

    Bidirectional risk between venous thromboembolism and cancer in East Asian patients: synthesis of evidence from recent population-based epidemiological studies.
    Cancer Manag Res 2017 5;9:751-759. Epub 2017 Dec 5.
    Division of Medical Oncology, Cancer Center, Kuang Tien General Hospital.
    Background: Unprovoked (idiopathic) venous thromboembolism (VTE) with no obvious antecedent risk factors, is associated with a significant risk of subsequent occult cancer. Conversely, there is a heightened risk of VTE in cancer patients. This bidirectional risk can be estimated from population-based cohort studies conducted in East Asians. Read More

    Sites of metastasis and overall survival in esophageal cancer: a population-based study.
    Cancer Manag Res 2017 6;9:781-788. Epub 2017 Dec 6.
    Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People's Republic of China.
    Background: There are few population-based studies of the sites of distant metastasis (DM) and survival from esophageal cancer (EC). The aim of this study was to assess the patterns and survival outcomes for site-specific DM from EC using a population-based approach.

    Methods: Patients diagnosed with de novo stage IV EC between 2010 and 2014 were identified from the Surveillance, Epidemiology, and End Results program database. Read More

    Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma.
    Cancer Manag Res 2017 30;9:741-750. Epub 2017 Nov 30.
    Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Okayama, Japan.
    Programmed cell death-1 ligand 1 (PD-L1), tumor-infiltrating CD8-positive T lymphocytes (CD8-positive TILs), and cyclooxygenase-2 (Cox-2) have been used as prognostic tools in patients with lung adenocarcinoma. We conducted a retrospective review of data from 170 patients who had undergone pulmonary resection as an initial treatment for clinical T1-2 N0 lung adenocarcinoma. We then investigated the expressions of three biomarkers using immunohistochemical analyses and compared the expression levels with the clinicopathological characteristics and outcomes of the patients. Read More

    The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma.
    Cancer Manag Res 2017 29;9:731-739. Epub 2017 Nov 29.
    Precision Health Economics, Los Angeles, CA, USA.
    Objective: To examine how observed medication nonadherence to 2 second-line, oral anticancer medications (axitinib and everolimus) affects progression-free survival (PFS) among patients with renal cell carcinoma.

    Methods: We used an adherence-exposure-outcome model to simulate the impact of adherence on PFS. Using a pharmacokinetic/pharmacodynamic (PK/PD) population model, we simulated drug exposure measured by area under the plasma concentration-time curve (AUC) and minimum blood or trough concentration (C) under 2 scenarios: 1) optimal adherence and 2) real-world adherence. Read More

    The burden of selected cancers in the US: health behaviors and health care resource utilization.
    Cancer Manag Res 2017 28;9:721-730. Epub 2017 Nov 28.
    Pfizer Inc.
    Objective: To characterize the disease burden among survivors of those cancers having the highest incidence in the US.

    Methods: Adult (≥18 years) survivors of the 11 most frequently diagnosed cancers were identified from publically available data sources, including the Surveillance Epidemiology and End Results 9 1973-2012, National Health Interview Survey 2013, and the Medical Expenditure Panel Survey 2011. Chi-square tests and one-way analyses of variance were utilized to assess differences between cancer survivors and non-cancer controls in behavioral characteristics, symptoms and functions, preventative screenings, and health care costs. Read More

    Selective serotonin reuptake inhibitors and the risk of hepatocellular carcinoma in hepatitis B virus-infected patients.
    Cancer Manag Res 2017 28;9:709-720. Epub 2017 Nov 28.
    Department of Emergency Medicine, Taipei Veterans General Hospital.
    Background: This study aimed to investigate the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection.

    Methods: We conducted a population-based cohort study by using claims data from the Taiwan National Health Insurance Research Database (NHIRD). The study cohort comprised 1380 newly diagnosed HBV-infected patients with SSRI use who were frequency matched by age, sex, liver cirrhosis, and index year with HBV-infected patients without SSRI use in the comparison cohort. Read More

    Density of CD8+ lymphocytes in biopsy samples combined with the circulating lymphocyte ratio predicts pathologic complete response to chemoradiotherapy for rectal cancer.
    Cancer Manag Res 2017 27;9:701-708. Epub 2017 Nov 27.
    Department of Colorectal Surgery.
    Objectives: The systemic status and local immune status, as determined by the neutrophil-lymphocyte ratio (NLR) or the lymphocyte ratio (LYMR) and tumor-infiltrating lymphocyte (TIL) count, respectively, have been suggested as predictors of the tumor response to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, although the utility of these measures remains controversial. We aimed to investigate the values of the LYMR, NLR and TIL count and their combinations (TIL-LYMR/TIL-NLR) in predicting pathologic complete response (pCR) after nCRT.

    Patients And Methods: Pretreatment biopsy samples and data from the blood tests of 92 patients with rectal cancer who underwent curative resection after nCRT were retrospectively obtained. Read More

    Mesenchymal phenotype of circulating tumor cells is associated with distant metastasis in breast cancer patients.
    Cancer Manag Res 2017 23;9:691-700. Epub 2017 Nov 23.
    Department of Oncology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, China.
    In this study, we investigated the relationship between the epithelial-mesenchymal transition phenotype of circulating tumor cells (CTCs) and distant metastasis in breast cancer patients. We analyzed the expression of epithelial (epithelial cell adhesion molecule, cytokeratin [CK]8, CK18 and CK19) and mesenchymal (vimentin and TWIST1) markers in CTCs from a large cohort of Chinese breast cancer patients (N=1083) using Canpatrol™ CTC assays. We identified CTCs in 84. Read More

    Prognostic and clinicopathological value of Ki-67/MIB-1 expression in renal cell carcinoma: a meta-analysis based on 4579 individuals.
    Cancer Manag Res 2017 21;9:679-689. Epub 2017 Nov 21.
    Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
    Background: Previous studies have investigated the prognostic significance of Ki-67/MIB-1 expression in renal cell carcinoma (RCC), however, the reports are controversial and inconsistent. This study aimed to investigate Ki-67/MIB-1 expression in RCC and its correlation with prognosis and clinicopathological features.

    Methods: We searched relevant studies that reported associations between Ki-67/MIB-1 expression and prognosis in RCC from PubMed, Embase, Web of Science, and Cochrane Library studies published until April 14, 2017. Read More

    Efficacy and safety of pemetrexed and nedaplatin followed by pemetrexed maintenance therapy in advanced lung adenocarcinoma.
    Cancer Manag Res 2017 20;9:671-677. Epub 2017 Nov 20.
    Department of Medical Oncology, The Fifth Affiliated Hospital of Sun-Yat-Sen University, Zhuhai, Guangdong, People's Republic of China.
    Objective: To evaluate the efficacy and safety of pemetrexed and nedaplatin followed by pemetrexed maintenance therapy in advanced lung adenocarcinoma.

    Methods: A total of 53 advanced lung adenocarcinoma patients hospitalized between July 2013 and June 2016 with a performance status ≤2 were enrolled in this study. All patients received 4-6 cycles of combination chemotherapy comprising pemetrexed (500 mg/mdL) and nedaplatin (80 mg/mdL). Read More

    Training surgeons in shared decision-making with cancer patients aged 65 years and older: a pilot study.
    Cancer Manag Res 2017 10;9:591-600. Epub 2017 Nov 10.
    Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
    Objective: Treatment decision-making in older patients with colorectal (CRC) or pancreatic cancer (PC) needs improvement. We introduced the EASYcare in Geriatric Onco-surgery (EASY-GO) intervention to optimize the shared decision-making (SDM) process among these patients.

    Methods: The EASY-GO intervention comprised a working method with geriatric assessment and SDM training for surgeons. Read More

    1 OF 8