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    485 results match your criteria Cancer Management and Research [Journal]

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    Cystectomy for bladder cancer in elderly patients is not associated with increased 30- and 90-day mortality or readmission, length of stay, and cost: propensity score matching using a population database.
    Cancer Manag Res 2018 31;10:1413-1418. Epub 2018 May 31.
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
    Purpose: Radical cystectomy (RC) is an effective but underused treatment for bladder cancer in elderly patients. This study performed analysis of propensity scores (PSs) to determine the outcomes of RC for elderly patients, with results generalizable at the population-based level.

    Patients And Methods: We conducted a population-based, retrospective cohort study of patients who underwent RC in Taiwan during 2000-2010. Read More

    Prognostic value and clinical significance of long noncoding RNA CASC2 in human malignancies: a meta-analysis.
    Cancer Manag Res 2018 31;10:1403-1412. Epub 2018 May 31.
    Department of Oncology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
    Purpose: This meta-analysis aimed to assess the prognostic value of long noncoding RNA cancer susceptibility candidate 2 (CASC2) in human tumors.

    Materials And Methods: We searched the available databases up to December 2017. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to examine the prognostic impact of CASC2 on overall survival (OS) in patients diagnosed with malignancies. Read More

    Combined microwave ablation and minimally invasive open decompression for the management of thoracic metastasis in breast cancer.
    Cancer Manag Res 2018 31;10:1397-1401. Epub 2018 May 31.
    Department of Breast Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
    Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Read More

    Performance status dynamics during treatment with -paclitaxel plus gemcitabine versus gemcitabine alone for metastatic pancreatic cancer.
    Cancer Manag Res 2018 31;10:1389-1396. Epub 2018 May 31.
    Department of Medical Oncology, Prince of Wales Hospital, Sydney, NSW, Australia.
    Objectives: This analysis examined changes in Karnofsky performance status (KPS) as a surrogate for patient's well-being during treatment with -paclitaxel plus gemcitabine vs gemcitabine alone as first-line therapy for metastatic pancreatic cancer (MPC) in the Phase III MPACT trial.

    Participants And Methods: Descriptive analyses were performed for KPS at three time points (3 and 6 months after randomization and 1 month before disease progression) and for time to any KPS deterioration. Time to definitive KPS deterioration (≥10-point KPS decrease from baseline) was calculated using the Kaplan-Meier method. Read More

    Polymorphism in lncRNA AC008392.1 and its interaction with smoking on the risk of lung cancer in a Chinese population.
    Cancer Manag Res 2018 30;10:1377-1387. Epub 2018 May 30.
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, People's Republic of China.
    Purpose: To evaluate the association between rs7248320 in lncRNA AC008392.1 and the risk of lung cancer, this case-control study was carried out in a Chinese population. This study also evaluated the gene-environment interaction between rs7248320 and exposure to smoking status on the risk of lung cancer. Read More

    Tumor-infiltrating lymphocyte as a prognostic biomarker in stage IV colorectal cancer should take into account the metastatic status and operation modality.
    Cancer Manag Res 2018 30;10:1365-1375. Epub 2018 May 30.
    VIP Region, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
    Background: Although tumor-infiltrating lymphocytes (TILs) have been understood for years as a favorable prognostic factor for colorectal cancers (CRCs) after complete surgical resection, its prognostic role in metastatic CRC (mCRC) remains poorly defined, and it is largely unknown how this prognostic benefit relates to the metastatic status and operation modality.

    Materials And Methods: After reviewing 2215 consecutive cases of surgically resected CRC, 332 patients newly diagnosed with stage IV CRC and treated at the Sun Yat-Sen University Cancer Center between 2009 and 2014 were included. H&E-stained (HES) slides from surgical specimens were evaluated for the extent of TILs. Read More

    Age distribution and age-related outcomes of olfactory neuroblastoma: a population-based analysis.
    Cancer Manag Res 2018 29;10:1359-1364. Epub 2018 May 29.
    Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, People's Republic of China.
    Objective: The objective of the study was to describe the age distribution and to evaluate the role of prognostic value of age on survival in patients diagnosed with olfactory neuroblastoma (ONB). A population-based retrospective analysis was conducted.

    Materials And Methods: The population-based study of patients in the Surveillance, Epidemiology, and End Results (SEER) tumor registry, who were diagnosed with ONB from 1973 to 2014, were retrospectively analyzed. Read More

    Clinical effect of and its relevance to V600E mutation in papillary thyroid carcinoma: a case-control study.
    Cancer Manag Res 2018 29;10:1351-1358. Epub 2018 May 29.
    Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Aim: To investigate the clinical effects of on papillary thyroid cancer (PTC) and explore the relationship between expression and mutation.

    Methods: The data of 69 patients subjected to fine-needle aspiration biopsy in our hospital and 486 patient data downloaded from The Cancer Genome Atlas (TCGA) database were used. Univariate and multivariate analyses were performed. Read More

    Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
    Cancer Manag Res 2018 25;10:1341-1349. Epub 2018 May 25.
    Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
    Background: The relationship between TP53 codon 72 Pro/Arg gene polymorphism and colorectal cancer risk in Asians is still controversial, and this bioinformatics analysis and meta-analysis was performed to assess the associations.

    Methods: The association studies were identified from PubMed, and eligible reports were included. RevMan 5. Read More

    Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer.
    Cancer Manag Res 2018 24;10:1329-1340. Epub 2018 May 24.
    Department of Surgery, Duke University Medical Center, Durham, NC, USA.
    Background: Squamous non-small cell lung cancer (SqNSCLC), as a leading cause of cancer-related deaths worldwide, has limited treatment options and poor prognosis. Thus, novel targeted therapies are desperately needed.

    Materials And Methods: SqNSCLC cases from derivation and validation cohorts were ana-lyzed for podoplanin (PDPN) expression, and its clinicopathological correlation and prognostic prediction. Read More

    Association of FGFR2 and PI3KCA genetic variants with the risk of breast cancer in a Chinese population.
    Cancer Manag Res 2018 21;10:1305-1311. Epub 2018 May 21.
    Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China.
    Purpose: Genome-wide association studies have found plenty of single nucleotide polymorphisms (SNPs) which are associated with breast cancer risk. SNPs in FGFR2 are mostly identified. However, the association between PI3KCA SNP and breast cancer risk remains largely unknown. Read More

    Stereotactic body radiation therapy plus induction or adjuvant chemotherapy for early stage but medically inoperable pancreatic cancer: A propensity score-matched analysis of a prospectively collected database.
    Cancer Manag Res 2018 21;10:1295-1304. Epub 2018 May 21.
    Departmant of Radiation Oncology, Changhai Hospital affiliated to Navy Medical University, Shanghai, China.
    Background: To evaluate and compare the efficacy and safety of stereotactic body radiation therapy (SBRT) plus induction chemotherapy and SBRT plus adjuvant therapy.

    Methods: Patients with radiographically resectable, biopsy-proven pancreatic cancer were enrolled. Data were prospectively collected from 2012 to 2016. Read More

    Associated factors for oral health problems in a sample of Saudi cancer patients.
    Cancer Manag Res 2018 21;10:1285-1293. Epub 2018 May 21.
    King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard, Riyadh, Saudi Arabia.
    Purpose: Oral health in cancer patients was known to influence the quality of life. However, the knowledge of possible factors associated with oral health in cancer patients is seriously lacking in Saudi Arabia. In this study, we aimed to determine the burden of adverse oral health in cancer patients and identify the associated factors for oral health problems. Read More

    Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies.
    Cancer Manag Res 2018 21;10:1201-1207. Epub 2018 May 21.
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
    Background: The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD.

    Materials And Methods: We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines. Read More

    Matching-adjusted indirect treatment comparison of ribociclib and palbociclib in HR+, HER2- advanced breast cancer.
    Cancer Manag Res 2018 22;10:1319-1327. Epub 2018 May 22.
    Novartis Pharmaceutical Corporation, East Hanover, NJ, USA.
    Background: Ribociclib (RIBO) and palbociclib (PALBO), combined with letrozole (LET), have been evaluated as treatments for hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in separate Phase III randomized controlled trials (RCTs), but not head-to-head. Population differences can lead to biased results by classical indirect treatment comparison (ITC). Matching-adjusted indirect comparison (MAIC) aims to correct these differences. Read More

    Clinical analysis of four serum tumor markers in 458 patients with ovarian tumors: diagnostic value of the combined use of HE4, CA125, CA19-9, and CEA in ovarian tumors.
    Cancer Manag Res 2018 22;10:1313-1318. Epub 2018 May 22.
    Department of Clinical Laboratory, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, People's Republic of China.
    Purpose: To investigate the diagnostic values of human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) for ovarian tumors.

    Methods: The participants were divided into three groups: 386 healthy women (control group), 262 patients with benign ovarian tumors (the benign group), and 196 patients with malignant pelvic tumors (the malignant group). The serum levels of HE4, CA125, CA19-9, and CEA were analyzed by electrochemiluminescent immunoassay. Read More

    Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma.
    Cancer Manag Res 2018 18;10:1275-1283. Epub 2018 May 18.
    Department of Internal Medicine-Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
    Aim: The aim of this study was to analyze the diagnostic and prognostic values of the circular RNA (circRNA) hsa_circ_0128298 in hepatocellular carcinoma (HCC).

    Patients And Methods: The global circRNA expression was measured using circRNA microarray using three pairs of cancer and noncancerous tissues from HCC patients. The microarray analysis revealed that two circRNAs were differentially expressed in the three pairs of cancerous and noncancerous tissues. Read More

    Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies.
    Cancer Manag Res 2018 17;10:1259-1273. Epub 2018 May 17.
    Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan.
    With the increasing use of targeted anticancer drugs and immunotherapies, there have been a substantial number of reports concerning life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms, drug-induced hypersensitivity syndrome, and acute generalized exanthematous pustulosis. Although the potential risks and characteristics for targeted anticancer agent- and immunotherapy-induced SCAR were not well understood, these serious adverse reactions usually result in morbidity and sequela. As a treatment guideline for this devastating condition is still unavailable, prompt withdrawal of causative drugs is believed to be a priority of patient management. Read More

    The location, histologic type, and stage of lung cancer are associated with bleeding during endobronchial biopsy.
    Cancer Manag Res 2018 17;10:1251-1257. Epub 2018 May 17.
    Department of Respiratory Medicine, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.
    Background: Several risk factors have been proposed for bleeding during bronchoscopy, including immunosuppression, thrombocytopenia, pulmonary arterial hypertension, and mechanical ventilation. However, research on bronchoscopic biopsy-induced bleeding in the population of lung cancer without these "proposed risk factors" remains lacking.

    Patients And Methods: A total of 531 lung cancer patients with endobronchial biopsy (EBB) were enrolled in this retrospective observational study. Read More

    Expression and significance of RRBP1 in esophageal carcinoma.
    Cancer Manag Res 2018 17;10:1243-1249. Epub 2018 May 17.
    Department of Radiation Therapy, Cangzhou Central Hospital, Cangzhou, China.
    Objective: This study was to investigate the expression and clinical significance of RRBP1 in esophageal carcinoma.

    Materials And Methods: RRBP1 expression was detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the relationship of RRBP1 with clinicopathological characteristics and prognosis was analyzed.

    Results: RRBP1 was highly expressed in esophageal carcinoma tissues compared with matched adjacent normal tissues (<0. Read More

    Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer.
    Cancer Manag Res 2018 16;10:1231-1241. Epub 2018 May 16.
    Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China.
    Background: Chemotherapy is still the primary adjuvant strategy of cancer therapy; however, the emergence of multi-drug resistance has been a cause for concern. Autophagy has been demonstrated to have a protective role against chemotherapeutic drugs in cancer cells, and autophagy inhibition is generally considered to be a promising therapeutic strategy. However, the paucity of effective and specific autophagy inhibitors limits its application. Read More

    Role of in cervical cancer.
    Cancer Manag Res 2018 16;10:1219-1229. Epub 2018 May 16.
    Department of Medical Oncology.
    Cervical cancer is a common malignant cancer among women worldwide. Changes in the vaginal microecological environment lead to multiple gynecological diseases, including cervical cancer. Recent research has shown that may play an important role in the occurrence and development of cervical cancer. Read More

    Diagnostic accuracy of droplet digital PCR for detection of EGFR T790M mutation in circulating tumor DNA.
    Cancer Manag Res 2018 16;10:1209-1218. Epub 2018 May 16.
    Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Objectives: Although different methods have been established to detect epidermal growth factor receptor (EGFR) T790M mutation in circulating tumor DNA (ctDNA), a wide range of diagnostic accuracy values were reported in previous studies. The aim of this meta-analysis was to provide pooled diagnostic accuracy measures for droplet digital PCR (ddPCR) in the diagnosis of EGFR T790M mutation based on ctDNA.

    Materials And Methods: A systematic review and meta-analysis were carried out based on resources from Pubmed, Web of Science, Embase and Cochrane Library up to October 11, 2017. Read More

    Prognostic factors for survival among patients with primary bone sarcomas of small bones.
    Cancer Manag Res 2018 14;10:1191-1199. Epub 2018 May 14.
    Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, Hangzhou, China.
    Background: Primary bone sarcomas of the hands or feet are rare lesions and poorly documented. Moreover, the prognostic determinants of bone sarcomas of the hands or feet have not been reported.

    Materials And Methods: The Surveillance, Epidemiology, and End Results (SEER) program database was used to screen patients with bone sarcomas of the hands or feet from 1973 to 2013, with attention paid to chondrosarcoma, Ewing sarcoma, and osteosarcoma. Read More

    Preoperative serum apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients.
    Cancer Manag Res 2018 14;10:1177-1190. Epub 2018 May 14.
    Department of Urology, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China.
    Introduction: The aim of this study was to elucidate the association between apolipoprotein A-I (Apo A-I) and overall survival (OS) as well as cancer-specific survival (CSS) in non-muscle-invasive bladder cancer (NMIBC) patients undergoing transurethral resection of bladder tumor (TURBT).

    Patients And Methods: We retrospectively collected data of 470 eligible patients diagnosed with NMIBC and who received TURBT between January 2004 and December 2011. Pretreatment blood indexes were examined. Read More

    Overexpression of chloride channel-3 predicts unfavorable prognosis and promotes cellular invasion in gastric cancer.
    Cancer Manag Res 2018 14;10:1163-1175. Epub 2018 May 14.
    Gastrointestinal Surgical Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
    Background: Chloride channel-3 (CLC-3) has been reported to promote the proliferation and invasion in various tumors, yet little is known about its role in gastric cancer. In the present study, we investigated the clinical significance of CLC-3 and its biological role in gastric cancer.

    Methods: Bioinformatic analysis, immunohistochemical staining, quantitative real-time polymerase chain reaction and Western blot assay were used to assess the expression of CLC-3 and its clinical significance in gastric cancer. Read More

    The lncRNA myocardial infarction associated transcript-centric competing endogenous RNA network in non-small-cell lung cancer.
    Cancer Manag Res 2018 14;10:1155-1162. Epub 2018 May 14.
    Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Affiliated Hospital, China Medical University, Shenyang 110001, People's Republic of China.
    Background: The leading cause of death for cancer is lung cancer, of which the majority subtype is non-small cell lung cancer (NSCLC). Recent studies have shown long non-coding RNAs are transcribed and contribute to cancer. Previous study has shown that a few single nucleotide polymorphisms (SNPs) in myocardial infarction associated transcript (MIAT) were associated with some diseases or function as competing endogenous RNA (ceRNA) in some cancer. Read More

    variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project.
    Cancer Manag Res 2018 14;10:1143-1154. Epub 2018 May 14.
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
    Purpose: Melanoma represents an important public health problem, due to its high case-fatality rate. Identification of individuals at high risk would be of major interest to improve early diagnosis and ultimately survival. The aim of this study was to evaluate whether variants predicted melanoma risk independently of at-risk phenotypic characteristics. Read More

    Decreased survival in patients with carcinoma of axillary tail versus upper outer quadrant breast cancers: a SEER population-based study.
    Cancer Manag Res 2018 14;10:1133-1141. Epub 2018 May 14.
    Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
    Background: Carcinoma of the axillary tail of Spence (CATS) is a poorly studied type of breast cancer. The clinicopathological characteristics and prognostic features of CATS are unclear.

    Methods: Using the Surveillance, Epidemiology, and End Results database, we identified 149,026 patients diagnosed with upper outer quadrant breast cancer (UOBC) (n=146,343) or CATS (n=2,683). Read More

    Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
    Cancer Manag Res 2018 10;10:1125-1131. Epub 2018 May 10.
    Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
    Objective: The efficacy of additional cores from cancer-suspicious lesions by transrectal ultrasound (TRUS) for the detection of prostate cancer (PCa) was assessed.

    Materials And Methods: Data were collected from 4144 men who underwent systematic 12-core biopsy with no cancer-suspicious lesions (Group A: 3256 cases) or 13- or more-core (systematic 12 core + additional cores) biopsy with cancer-suspicious lesions (Group B: 888 cases) on TRUS-guided biopsy. The effect of additional biopsy cores on the cancer detection rate was investigated. Read More

    Blockage of store-operated Ca entry antagonizes Epstein-Barr virus-promoted angiogenesis by inhibiting Ca signaling-regulated VEGF production in nasopharyngeal carcinoma.
    Cancer Manag Res 2018 10;10:1115-1124. Epub 2018 May 10.
    Department of Medical Oncology, Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, People's Republic of China.
    Background: Epstein-Barr virus (EBV) actively contributes to the pathological process of nasopharyngeal carcinoma (NPC) by enabling NPC cells to acquire various capacities required for their malignant biological actions. Our earlier works demonstrated that EBV-encoded latent membrane protein 1 (LMP1) enhanced vascular endothelial growth factor (VEGF)-mediated angiogenesis by boosting store-operated Ca entry (SOCE) upon extracellular epidermal growth factor (EGF) stimulation. However, the antagonistic effects of SOCE blockage on EBV-promoted angiogenesis must be appropriately evaluated in vivo, and the global effect of EBV infection on the EGF-elicited cytosolic Ca signaling, which regulates VEGF-mediated angiogenesis remains to be further clarified. Read More

    A review of soft-tissue sarcomas: translation of biological advances into treatment measures.
    Cancer Manag Res 2018 10;10:1089-1114. Epub 2018 May 10.
    Thoracic Oncology Program, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
    Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an overall incidence of about five per 100,000 per year. While this diverse family of malignancies comprises over 100 histological subtypes and many molecular aberrations are prevalent within specific sarcomas, very few are therapeutically targeted. Instead of utilizing molecular signatures, first-line sarcoma treatment options are still limited to traditional surgery and chemotherapy, and many of the latter remain largely ineffective and are plagued by disease resistance. Read More

    Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway.
    Cancer Manag Res 2018 10;10:1079-1088. Epub 2018 May 10.
    Department of Natural Sciences, Lebanese American University, Beirut, Lebanon.
    Background: Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that is used in the treatment of many types of cancers including leukemia, but it has significant side effects. Andrographolide, a compound extracted from , was recently proven to inhibit the growth of cancer cells and can induce apoptosis. The aim of this study is to investigate the possible synergism between TP and andrographolide in acute myeloid cells in vitro. Read More

    Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review.
    Cancer Manag Res 2018 9;10:1069-1078. Epub 2018 May 9.
    Department of Ophthalmology.
    Purpose: To report the clinical features, imaging manifestations, histopathology, and immunohistochemical features of several cases of orbital solitary fibrous tumors (SFTs) in a Chinese tertiary hospital, and to undertake a literature review of this rare disease.

    Methods: A non-comparative retrospective review of clinical presentations, imaging manifestations, histopathology, and immunohistochemical features as well as the management and disease outcomes of patients with orbital SFT was conducted along with a review of orbital SFT cases in the literature.

    Results: This study includes two male and two female patients, with an average age of 53 years. Read More

    Survival outcomes of radical prostatectomy and external beam radiotherapy in clinically localized high-risk prostate cancer: a population-based, propensity score matched study.
    Cancer Manag Res 2018 8;10:1061-1067. Epub 2018 May 8.
    Department of Radiation Oncology, Rush University Medical Center, Chicago, IL, USA.
    Objective: This study was aimed to compare survival outcomes in high-risk prostate cancer (PCa) patients receiving external beam radiotherapy (EBRT) or radical prostatectomy (RP).

    Materials And Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify PCa patients with high-risk features who received RP alone or EBRT alone from 2004 to 2008. Propensity-score matching (PSM) was performed. Read More

    Triple-negative and HER2-overexpressing breast cancer cell sialylation impacts tumor microenvironment T-lymphocyte subset recruitment: a possible mechanism of tumor escape.
    Cancer Manag Res 2018 4;10:1051-1059. Epub 2018 May 4.
    INSERM U976; Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, Paris, France.
    Introduction: Breast cancers develop different patterns of sialylation to modulate their tumor-infiltrating lymphocyte (TIL) environment. We studied the relationship between α-2,6 sialyltransferases and the TIL in different breast cancer molecular subgroups.

    Materials And Methods: Immunohistochemical preparations were made from 39 luminal (LUM), 13 human epidermal growth factor receptor 2-overexpressing (HER2) and 47 triple-negative (TN) breast carcinomas. Read More

    Genetic variants of -rs671 and -rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.
    Cancer Manag Res 2018 4;10:1037-1050. Epub 2018 May 4.
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, China.
    Objective: Acetaldehyde dehydrogenase 2 () and cytochrome P450 2E1 () have been associated with hepatocellular carcinoma (HCC) susceptibility and prognosis. The polymorphisms rs671 and rs2031920 are reportedly correlated with the prevalence of HCC in other countries. The aim of this study was to investigate associations between and , and HCC susceptibility in a population of Guangxi, southern China, an area with a high incidence of HCC. Read More

    Genetic variants in the exon region of versican predict survival of patients with resected early-stage hepatitis B virus-associated hepatocellular carcinoma.
    Cancer Manag Res 2018 4;10:1027-1036. Epub 2018 May 4.
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
    Background: The upregulated expression of versican (VCAN) promotes the proliferation, invasion, and metastasis of various types of human cancer cells, including hepatocellular carcinoma (HCC) cells.

    Patients And Methods: In this study, genetic variants in the exon region of were genotyped by DNA sequencing. Prognostic values of exon single nucleotide polymorphisms (SNPs) were assessed by Kaplan-Meier with the log-rank test, and uni- and multivariate Cox proportional hazard regression model. Read More

    Is progression-free survival a more relevant endpoint than overall survival in first-line HR+/HER2- metastatic breast cancer?
    Cancer Manag Res 2018 4;10:1015-1025. Epub 2018 May 4.
    Health Economics, Purple Squirrel Economics, New York, NY, USA.
    Background: Hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), metastatic breast cancer (MBC) accounts for 73% of all MBCs. Endocrine therapy (ET) is the basis of first-line (1L) therapy for patients with HR+/HER2- MBC. Novel therapies have demonstrated improvements in progression-free survival (PFS) compared to ET. Read More

    Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative-intent surgery for hepatocellular carcinoma: experience from a developing country.
    Cancer Manag Res 2018 4;10:977-988. Epub 2018 May 4.
    HPB Unit, Clinic for Digestive Surgery, Clinical Center of Serbia, Belgrade, Serbia.
    Purpose: The aim of the study was to evaluate a prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on long-term survival of cirrhotic and noncirrhotic hepatocellular cancer (HCC) patients managed by a curative-intent liver surgery in a developing country.

    Patients And Methods: During the study period between November 1, 2001, and December 31, 2012, 109 patients underwent potentially curative hepatectomy for HCC. Data were retrospectively reviewed from the prospectively collected database. Read More

    Co-existence of and promoter mutations in papillary thyroid carcinoma is associated with tumor aggressiveness, but not with lymph node metastasis.
    Cancer Manag Res 2018 3;10:1005-1013. Epub 2018 May 3.
    Department of Endocrine and Breast Surgery.
    Background: Mutations of and promoters are associated with thyroid cancer development. This study further investigated association of these mutations with clinicopathological characteristics from patients with papillary thyroid carcinoma (PTC).

    Methods: Tumor tissues from 342 PTC patients were obtained for DNA extraction and polymerase chain reaction amplification to detect the mutation using amplification-refractory mutation system-polymerase chain reaction. Read More

    MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells.
    Cancer Manag Res 2018 3;10:989-1003. Epub 2018 May 3.
    Department of Dermatology and Venereology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
    Background: gene plays an important role in melanoma, although the specific mechanism involved is unclear. The aim of this study was to screen and identify the relative miRNAs with the regulation of hTERT in melanoma.

    Materials And Methods: Quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to detect hTERT mRNA and protein expression in 36 formalin-fixed paraffin-embedded melanoma tissues and 36 age- and sex-matched pigmented nevi cases, respectively. Read More

    functions as a tumor suppressor and regulates migration and invasion in breast cancer.
    Cancer Manag Res 2018 1;10:969-976. Epub 2018 May 1.
    Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
    Background: Breast cancer is the most common malignancy in women and the underlying mechanism of breast cancer cell metastasis is still far from uncover. () is a functioning protein. It has been detected in many malignancies. Read More

    Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways associated with TP53 expression status in HBV-related hepatocellular carcinoma.
    Cancer Manag Res 2018 1;10:953-967. Epub 2018 May 1.
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
    Background: The aim of this investigation was to identify candidate single nucleotide polymorphisms (SNPs) and molecular pathways associated with tumor protein p53 (TP53) expression status in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), clarify their potential mechanisms, and generate SNP-to-gene to pathway hypothesis.

    Materials And Methods: Identify candidate Causal SNPs and Pathways (ICSNPathway) was used to perform pathway analysis based on the results of our previous genome-wide association study of TP53 expression status in 387 HBV-related HCC patients.

    Results: Through the ICSNPathway analysis, we identified 18 candidate SNPs and 10 candidate pathways that are associated with TP53 expression status in HBV-related HCC. Read More

    Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection.
    Cancer Manag Res 2018 1;10:941-951. Epub 2018 May 1.
    Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
    Background And Objective: Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8 T-cells contributes to CD8 T-cell exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble Tim-3 (sTim-3). This study investigated serum sTim-3 levels in patients with chronic HBV infection of various liver diseases. Read More

    Durvalumab: a potential maintenance therapy in surgery-ineligible non-small-cell lung cancer.
    Cancer Manag Res 2018 1;10:931-940. Epub 2018 May 1.
    Department of Thoracic Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
    Lung cancer is the most common cancer worldwide and the most common cause of cancer-related death. Non-small-cell lung cancer comprises ~87% of newly diagnosed cases of lung cancer, and nearly one-third of these patients have stage III disease. Despite improvements in the treatment of stage IV lung cancer, particularly with the introduction and dissemination of checkpoint inhibitors, very little progress has been made in the treatment of stage III lung cancer. Read More

    Prognostic value of microRNAs in colorectal cancer: a meta-analysis.
    Cancer Manag Res 2018 30;10:907-929. Epub 2018 Apr 30.
    Second Department of Clinical Oncology, Shengjing Hospital of China Medical University.
    Background: Numerous studies have shown that miRNA levels are closely related to the survival time of patients with colon, rectal, or colorectal cancer (CRC). However, the outcomes of different investigations have been inconsistent. Accordingly, a meta-analysis was conducted to study associations among the three types of cancers. Read More

    A favorable tumor size to define papillary thyroid microcarcinoma: an analysis of 1176 consecutive cases.
    Cancer Manag Res 2018 27;10:899-906. Epub 2018 Apr 27.
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China.
    Background: The optimal treatment strategy for papillary thyroid microcarcinoma (PTMC) has remained controversial. The purpose of this study was to provide a new reference value for PTMC to aid the selection of optimal management for minute lesions.

    Patients And Methods: A pool of 1176 consecutive patients who met the inclusion criteria were ultimately enrolled in this study. Read More

    Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation.
    Cancer Manag Res 2018 27;10:887-897. Epub 2018 Apr 27.
    Department of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China.
    Background: Paeoniflorin, a polyphenolic compound derived from (), has exhibited anticancer activity in various human cancers, including glioblastoma. However, the mechanisms underlying the effects of this compound have not been fully elucidated. Toll-like receptor 4 (TLR4) plays an important role in the regulation of cancer cell proliferation and progression, and high TLR4 expression in glioblastoma specimens is associated with a poor prognosis. Read More

    Liver-enriched activator protein 1 as an isoform of CCAAT/enhancer-binding protein beta suppresses stem cell features of hepatocellular carcinoma.
    Cancer Manag Res 2018 26;10:873-885. Epub 2018 Apr 26.
    Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, Shanghai, People's Republic of China.
    Purpose: Liver cancer stem cells (CSCs) are known to be associated with the development, survival, proliferation, metastasis, and recurrence of liver tumors. The aim of this study was to investigate the association of liver-enriched activator protein 1 (LAP1) with hepatocellular carcinoma (HCC) and liver CSCs (LCSCs) and explore the impact of LAP1 on LCSCs.

    Materials And Methods: Differences in LAP1 expression in liver cancer tissues versus matched para-tumoral liver tissues and LCSCs versus non-CSCs were analyzed by Western blotting, real-time polymerase chain reaction, immunohistochemistry, and flow cytometry. Read More

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