1,212 results match your criteria Cancer Management and Research [Journal]


Inhibition of human glioblastoma cell invasion involves PION@E6 mediated autophagy process.

Cancer Manag Res 2019 29;11:2643-2652. Epub 2019 Mar 29.

Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guangxi, People's Republic of China,

Background: Glioblastoma (GBM) is the most severe brain cancer due to its ability to invade surrounding brain tissue. Iron oxide nanoparticles (ION) could effectively induce a decrease of cell migration/invasion. Also IONs could generate ROS stress which induces autophagy elevation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S200151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446987PMC

Biliary tract cancers: current knowledge, clinical candidates and future challenges.

Cancer Manag Res 2019 29;11:2623-2642. Epub 2019 Mar 29.

Faculty of Biomedicine and Health Sciences, Division of Cancer Sciences, University of Manchester, Manchester M13 9NT, UK,

Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S157092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446989PMC

Clinical features and prognostic factors of primary bone marrow lymphoma.

Cancer Manag Res 2019 29;11:2553-2563. Epub 2019 Mar 29.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China,

Background: Primary bone marrow lymphoma (PBML) is a very uncommon neoplasm originally arising in the bone marrow system, and the most common pathological type is diffuse large B-cell lymphoma.

Patients And Methods: To describe the clinical characteristics of PBML and evaluate the risk factors related to prognosis, we recruited and studied 66 patients from our center and the current published literature. Various symptoms are present at the onset of PBML, the most important of which is cytopenia, followed by fever. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S187522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446986PMC

Clinical value of ROMA index in diagnosis of ovarian cancer: meta-analysis.

Cancer Manag Res 2019 28;11:2545-2551. Epub 2019 Mar 28.

Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China,

Objectives: The role of retrospective analysis has evolved greatly in cancer research. We undertook this network meta-analysis to evaluate retrospectively the diagnostic value of ROMA in ovarian cancer.

Materials And Methods: We systematically retrieved 56 relevant articles published about ROMA index from 2009-2018 and about ovarian cancer from China National Knowledge Infrastructure (CNKI), PubMed and EMBASE. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/clinical-value-of-roma-index-in-di
Publisher Site
http://dx.doi.org/10.2147/CMAR.S199400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445184PMC
March 2019
2 Reads

Positive or close margins: reoperation rate and second conservative resection or total mastectomy?

Cancer Manag Res 2019 28;11:2507-2516. Epub 2019 Mar 28.

Department of Surgical Oncology, Paoli Calmettes Institute, 13009 Marseille, France.

Introduction: Reoperation after breast-conserving surgery (BCS) could be proposed for positive or close margins. Reoperation type, re-excision or mastectomy, depends on several factors in relation to patient's and tumor's characteristics. We have analyzed our breast cancer (BC) database in order to determine second and third attempts for BCS and mastectomy rates, as well as associated factors for type of surgery. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/positive-or-close-margins-reoperat
Publisher Site
http://dx.doi.org/10.2147/CMAR.S190852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445211PMC
March 2019
2 Reads

JAM3 functions as a novel tumor suppressor and is inactivated by DNA methylation in colorectal cancer.

Cancer Manag Res 2019 27;11:2457-2470. Epub 2019 Mar 27.

Department of Medical Oncology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China,

Purpose: JAM3, an adhesion and transmigration regulatory element, is abundantly expressed in intestinal epithelial cells. However, its expression and function in colorectal cancer (CRC) remain unknown. In this study, we explored its epigenetic mechanism and biological role in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S189937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441464PMC

Epigallocatechin-3-gallate-induced vascular normalization in A549-cell xenograft-bearing nude mice: therapeutic efficacy in combination with chemotherapy.

Cancer Manag Res 2019 27;11:2425-2439. Epub 2019 Mar 27.

Department of Respiratory Medicine, Key Site of National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China,

Purpose: Large-scale studies have revealed that appropriate antiangiogenic treatment enables the recovery of the normal structure and function of solid tumor vessels. Epigallocatechin-3-gallate (EGCG), a natural extract of green tea, has multiple effects on angiogenesis. However, normalization of blood vessels due to natural ingredients has not yet been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S187750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441461PMC
March 2019
1 Read

identified by comprehensive bioinformatic analysis as a hub candidate biological target in human epithelial ovarian cancer.

Cancer Manag Res 2019 25;11:2379-2392. Epub 2019 Mar 25.

Department of Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China,

Background: Epithelial ovarian cancer (EOC) is a female malignant tumor. Bioinformatics has been widely utilized to analyze genes related to cancer progression. Targeted therapy for specific biological factors has become more valuable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S189784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438265PMC
March 2019
1 Read

Comparison of transcriptional profiles in human lymphocyte cells irradiated with C ion beams at 0-2.0 Gy.

Cancer Manag Res 2019 22;11:2363-2369. Epub 2019 Mar 22.

China Institute for Radiation Protection, Taiyuan, Shanxi 030006, China,

Objective: Heavy ions have contributed to tumor site-specific radiotherapy and are a major health risk for astronauts. The purpose of this study was to investigate the changes in gene expression in peripheral lymphocytes of cancer patients and astronauts exposed to C ions, and identify suitable molecular biomarkers for health monitoring. We also aimed to observe the effects of treatment and the level of damage, by comparing the transcriptional profiles of human lymphocyte cell lines exposed to C ion beams at doses of 0-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S188959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434914PMC

Linc01194 acts as an oncogene in colorectal carcinoma and is associated with poor survival outcome.

Cancer Manag Res 2019 22;11:2349-2362. Epub 2019 Mar 22.

Department of Proctology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China,

Background: The incidence of colorectal cancer ranks among the top three malignant tumors, attributing to more than 50,000 deaths in the United States every year. Survival rate is directly correlated with TNM stage at diagnosis, and identifying the molecules involved in the cancer development process will provide directions to better investigate the mechanisms of colorectal cancer.

Materials And Methods: Bioinformatics analysis of differentially expressed long noncoding RNAs (lncRNAs), survival analysis, cell proliferation assay, migration assay, and Western blot analysis were performed. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/linc01194-acts-as-an-oncogene-in-c
Publisher Site
http://dx.doi.org/10.2147/CMAR.S189189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434913PMC
March 2019
2 Reads

UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway.

Cancer Manag Res 2019 22;11:2339-2348. Epub 2019 Mar 22.

Department of Oncology, HwaMei Hospital, University of Chinese Academy of Sciences, Zhejiang, China,

Background: Human melanoma is a malignant tumor originated from melanocytes with high invasion, metastasis, and poor prognosis. In this study, the effects of naphthalimides UNBS5162 and amonafide on the properties of proliferation and apoptosis in human melanoma cells were confirmed.

Methods: Cell proliferation was determined by CCK8 and clone formation assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S177623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434921PMC
March 2019
1 Read

A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment of -mutated breast cancer.

Cancer Manag Res 2019 22;11:2321-2337. Epub 2019 Mar 22.

Health Economics and Outcomes Research, Pfizer Inc., San Francisco, CA 94105, USA.

Purpose: To conduct a systematic review of international guidelines on screening and management of patients with -mutated breast cancer (BC).

Methods: Major electronic databases (MEDLINE and Embase; N=8) and gray literature sources were searched (January 2007 to February 2018). Latest guideline recommendations on genetic screening, counseling, and BC treatment of mutation carriers were summarized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S189627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434912PMC
March 2019
1 Read

The impact of the interval between the induction of chemotherapy and radiotherapy on the survival of patients with nasopharyngeal carcinoma.

Cancer Manag Res 2019 22;11:2313-2320. Epub 2019 Mar 22.

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China,

Background: There have been no reliable scientific studies examining whether the interval between induction chemotherapy (IC) and initiating radiotherapy is associated with poor outcomes of nasopharyngeal carcinoma (NPC).

Patients And Methods: In this retrospective study, we included a total of 239 local advanced NPC patients who underwent concurrent chemoradiotherapy and IC. Based on the interval between IC and intensity-modulated radiation therapy (IMRT), the patients were classified into three groups as follows: Group A (≤7 vs >7 days), Group B (≤14 vs >14 days), and Group C (≤ 21 vs >21 days). Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/the-impact-of-the-interval-between
Publisher Site
http://dx.doi.org/10.2147/CMAR.S195559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434908PMC
March 2019
1 Read

, an miRNA-875-3p target, suppresses cell proliferation, migration, and invasion in prostate cancer and serves as a potential prognostic biomarker.

Cancer Manag Res 2019 21;11:2299-2312. Epub 2019 Mar 21.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China,

Background: PF4V1 is a novel protein in inflammation, angiogenesis, and cancer. However, the pathogenesis, underlying mechanisms, and the prognostic value of PF4V1 in prostate cancer (PCa) are still unclear.

Materials And Methods: The PF4V1 expression and relation with survival were analyzed based on a large sample size in the Cancer Genome Atlas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S187831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432891PMC

Role of the pretreatment neutrophil-to-lymphocyte ratio in the survival of primary parotid cancer patients.

Cancer Manag Res 2019 21;11:2281-2286. Epub 2019 Mar 21.

Department of Head Neck and Thyroid, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, People's Republic of China.

Background: To analyze the value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the survival of patients with parotid cancer.

Methods: In total, 249 patients were enrolled. Information including age, sex, pretreatment NLR, and pathologic variables such as, tumor stage, intraparotid node (IPN) metastasis, and follow-up findings was extracted and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432895PMC
March 2019
1 Read

Primary tumor location is an important predictor of survival in pulmonary adenocarcinoma.

Cancer Manag Res 2019 21;11:2269-2280. Epub 2019 Mar 21.

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China,

Purpose: The prognostic value of tumor location in pulmonary adenocarcinoma (ADC) is controversial. We compared the prognosis and relevant data between central-type ADC (CT-ADC) and peripheral-type ADC (PT-ADC) in order to identify the reasons for the different outcomes between them and to improve the treatment strategy and prognosis of these two types.

Patients And Methods: Data of 256 patients with pathologically diagnosed ADC were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S192828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432898PMC
March 2019
1 Read

Is ramucirumab and paclitaxel therapy beneficial for second-line treatment of metastatic gastric or junctional adenocarcinoma for patients with ascites? Analysis of RAINBOW phase 3 trial data.

Cancer Manag Res 2019 20;11:2261-2267. Epub 2019 Mar 20.

Eli Lilly and Company, Taipei, Taiwan.

Purpose: Second-line treatment with ramucirumab-paclitaxel has demonstrated statistically significant and clinically meaningful survival outcomes compared to paclitaxel-alone in patients with advanced gastric cancer (HR=0.807, 95% CI 0.678-0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S193739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433106PMC
March 2019
1 Read

Influence of thoracic drainage fluid on proliferation, migration, apoptosis, and drug resistance in lung cancer cell lines.

Cancer Manag Res 2019 20;11:2253-2259. Epub 2019 Mar 20.

Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China,

Background: This study aimed to clarify the effect of thoracic drainage fluid (DF) on lung cancer cells in vitro.

Methods: We assessed the influence of DF on the proliferation and migration of lung cancer cells (LTEP-a-2 and A549) using the MTT cell proliferation assay and scratch wound assay. Cell apoptosis was determined by flow cytometric analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S187019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433100PMC

Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel.

Cancer Manag Res 2019 20;11:2241-2251. Epub 2019 Mar 20.

Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France,

Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, randomized studies are lacking, and treatment is based mainly on the recent published European Organisation for Research and Treatment of Cancer guidelines. Basically, early-stage MF is treated with skin-directed treatments, whereas advanced-stage MF requires more aggressive therapies. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/management-of-mycosis-fungoides-ty
Publisher Site
http://dx.doi.org/10.2147/CMAR.S138661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433101PMC
March 2019
10 Reads

Low-dose of olanzapine has ameliorating effects on cancer-related anorexia.

Cancer Manag Res 2019 19;11:2233-2239. Epub 2019 Mar 19.

Palliative Care Center, Chiba University Hospital, Chiba, Japan.

Background: Olanzapine (OLZ) has become well-known for its antiemetic effects on chemotherapy-induced nausea and vomiting. However, it remains unclear whether OLZ also has efficacy for treating cancer-related anorexia. This study, therefore, retrospectively examined whether or not OLZ administration affects the food intake in anorexic cancer patients who exhibit neither nausea nor vomiting. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/low-dose-of-olanzapine-has-amelior
Publisher Site
http://dx.doi.org/10.2147/CMAR.S191330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433113PMC
March 2019
1 Read

Nutritional status and related factors of patients with advanced lung cancer in northern China: a retrospective study.

Cancer Manag Res 2019 19;11:2225-2231. Epub 2019 Mar 19.

Department of Respiratory Medicine, Harbin Medical University Cancer Hospital, Harbin, China,

Background: Mortality of lung cancer in northern China has been increasing at an alarming speed. The consequences of malnutrition may include an increased risk of many complications. However, the nutritional status in advanced lung cancer patients is still unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S193567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433109PMC

Suppressed OGT expression inhibits cell proliferation and modulates EGFR expression in renal cell carcinoma.

Cancer Manag Res 2019 19;11:2215-2223. Epub 2019 Mar 19.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China,

Purpose: O-linked acetylglucosamine (-GlcNAc or -GlcNAcylation) is a post-translational modification, which plays a vital role in the progression of various cancers. The purpose of the present study was to assess -GlcNAcylation in human renal cell carcinoma (RCC).

Methods: O-GlcNAcylation levels and O-GlcNAc-transferase (OGT) expression in human RCC cell lines and 10 paired clinical tissues were detected by Western blot and Immunohistochemis-try. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S190642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433112PMC
March 2019
1 Read

Defining unmet clinical need across the pathway of brain tumor care: a patient and carer perspective.

Cancer Manag Res 2019 19;11:2189-2202. Epub 2019 Mar 19.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK,

Objective: The aim of this study was to determine the experience of patients with brain tumors and their carers across distinct parts of their treatment pathway and identify their views on potential service gaps in need of addressing.

Methods: A structured survey was administered at patient workshops across the UK and online through a charity newsletter. Answers to closed questions were analyzed using descriptive statistics, and open questions were examined using techniques of inductive content analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S175886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433107PMC

The oncogenic role of GNL3 in the progression and metastasis of osteosarcoma.

Cancer Manag Res 2019 15;11:2179-2188. Epub 2019 Mar 15.

Department of Pediatric Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China,

Background: GNL3 has been reported to be up-regulated in cancers and function in tumor progression, whereas the role of GNL3 in the progression of osteosarcoma remains unclear.

Materials And Methods: In this study, we blocked the expression of GNL3 by siRNA interference in osteosarcoma cell lines MG63 and U20S. CCK8, colony formation, wound-healing, Transwell, flow cytometry, and Hoechst/PI staining assays were used to examine the effects of GNL3 knockdown on cell proliferation, migration, invasion and apoptosis in MG63 and U20S cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421870PMC
March 2019
2 Reads

Etiology and management of nasopharyngeal hemorrhage after radiotherapy for nasopharyngeal carcinoma.

Cancer Manag Res 2019 15;11:2171-2178. Epub 2019 Mar 15.

Department of Otolaryngology, Hainan General Hospital, Haikou 570311, Hainan, China,

Objective: To analyze the etiology of nasopharyngeal hemorrhage after radiotherapy for nasopharyngeal carcinoma (NPC) and evaluate the relevant management and rescue approaches.

Methods: Seventeen cases of nasopharyngeal hemorrhage caused by radiotherapy of NPC, treated between January 2015 and March 2018, were retrospectively analyzed to study the etiology of nasopharyngeal hemorrhage. The management and rescue strategies, including anterior and posterior nostril packing, endoscopic nasopharynx electrocoagulation, and digital subtraction angiography embolization, were assessed for their effectiveness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S183537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421873PMC
March 2019
4 Reads

A multicenter study of a contrast-enhanced ultrasound diagnostic classification of breast lesions.

Cancer Manag Res 2019 15;11:2163-2170. Epub 2019 Mar 15.

Department of Ultrasound, Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China,

Purpose: To evaluate a classification model of contrast-enhanced ultrasound (CEUS) and examine the characteristics of patients with false-negative diagnosis.

Patients And Methods: A retrospective secondary analysis of a multicenter trial of CEUS for breast cancer diagnosis (from August 2015 to April 2017) was undertaken. Patients (n=1,023) with Breast Imaging Reporting and Data System 4-5 lesions on B-mode ultrasound underwent CEUS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S194868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421891PMC

State of the art for gastric signet ring cell carcinoma: from classification, prognosis, and genomic characteristics to specified treatments.

Cancer Manag Res 2019 15;11:2151-2161. Epub 2019 Mar 15.

Department of Human Anatomy, Medical University of Lublin, Lublin, Poland,

Gastric cancer (GC) is responsible for 9% of cancer deaths worldwide. Over 950,000 new cases are diagnosed each year, and about 90% of them are in advanced stage, requiring chemotherapy. In Europe there has been research based on pre- and postoperative chemotherapy treatment, using 5-fluorouracil, epirubicin, cisplatin, capecitabine, and docetaxel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S188622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421895PMC

Oncogenic role of ABHD5 in endometrial cancer.

Cancer Manag Res 2019 14;11:2139-2150. Epub 2019 Mar 14.

Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China,

Background: Abhydrolase domain containing 5 (ABHD5) functions as a tumor suppressor in colorectal and prostate cancers. The aim of this study was to investigate the roles of ABHD5 in endometrial cancer.

Materials And Methods: ABHD5 expression was detected in clinical samples by immunohistochemical staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S188648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421882PMC
March 2019
1 Read

Comparing the efficacy of concurrent EGFR-TKI and whole-brain radiotherapy vs EGFR-TKI alone as a first-line therapy for advanced -mutated non-small-cell lung cancer with brain metastases: a retrospective cohort study.

Cancer Manag Res 2019 14;11:2129-2138. Epub 2019 Mar 14.

Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

Background: Non-small-cell lung cancer (NSCLC) is a global public health problem, and brain is a common metastatic site in advanced NSCLC. Currently, whole-brain radiotherapy (WBRT) remains a major treatment for brain metastases, while EGFR-tyrosine kinase inhibitor (TKI) is the standard treatment for advanced NSCLC harboring mutations, which is also effective for brain metastases. However, whether EGFR-TKIs plus radiotherapy is superior to EGFR-TKIs alone for the treatment of advanced -mutant NSCLS with brain metastases remains controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S184922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421893PMC
March 2019
3 Reads

Evolution of the chemotherapeutic landscape and survival outcome in patients with metastatic pancreatic cancer: a four-institute cohort study in Taiwan, 2010-2016.

Cancer Manag Res 2019 14;11:2119-2127. Epub 2019 Mar 14.

Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.

Background: Only 5-fluorouracil (5-FU), cisplatin, and gemcitabine have been reimbursed for metastatic pancreatic cancer (mPC) treatment in Taiwan since 2003. It is uncertain whether the reimbursement of S-1 in June 2014 might change the treatment pattern and improve the survival of mPC patients in Taiwan.

Patients And Methods: A total of 645 patients with newly diagnosed mPC who received palliative chemotherapy between 2010 and 2016 in Taiwan were analyzed retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S196300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421872PMC

DR7 encoded by human herpesvirus 6 promotes glioma development and progression.

Cancer Manag Res 2019 12;11:2109-2118. Epub 2019 Mar 12.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China,

Purpose: We previously identified human herpesvirus 6 (HHV-6) infection in the pathogenesis of glioma. Direct repeat (DR)7, encoded by HHV-6, has been reported to possess malignant transforming activity and involved in Hodgkin's lymphoma carcinogenesis. Here, we aimed to determine the role of DR7 in the development and progression of glioma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S179762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419595PMC
March 2019
3 Reads

Decentralized colorectal cancer care in Germany over the last decade is associated with high in-hospital morbidity and mortality.

Cancer Manag Res 2019 12;11:2101-2107. Epub 2019 Mar 12.

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany,

Purpose: Despite several national initiatives, centralization of cancer care in Germany remains insufficient for most malignancies. Currently, there is a plethora of centers, including 290 voluntary certified and audited colorectal cancer (CRC) centers by the end of 2017, in the nation with many patients still being treated outside of such centers. This study aimed to assess morbidity and mortality rates of surgical procedures for primary colorectal CRC in Germany over the last decade through a comprehensive unbiased analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S197865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419594PMC

Axillary management still needed for patients with sentinel node micrometastases.

Cancer Manag Res 2019 8;11:2097-2100. Epub 2019 Mar 8.

Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China,

More attention has been paid to the axillary management over the past 50 years, and clinical practice has been changed as results of the random controlled trials. The American College of Surgeons Oncology Group Z0011 and International Breast Cancer Study Group (IBCSG) 23-01 trials provided high-level evidence to support the omission of axillary lymph nodes dissection (ALND) in sentinel lymph node (SLN)-positive patients receiving breast-conserving surgery (BCS) and adjuvant systemic treatment. In patients treated with BCS, whole breast irradiation (WBI) with tangential fields could lead to substantial axillary irradiation and control the residual tumor burden in axilla, whereas (intraoperative) partial breast irradiation has no therapeutic effect on these residual axillary metastases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S192573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413816PMC

Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique.

Cancer Manag Res 2019 8;11:2087-2096. Epub 2019 Mar 8.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

Background: Glucose transporter (GLUT)-mediated glucose uptake is an important process in the development of laryngeal carcinoma, one of the most common malignancies of the head and neck. GLUT-1, together with HIF-1α, is also an indicator of hypoxia. Both proteins play a critical role in glucose uptake and glycolysis in laryngeal carcinoma cells under hypoxic stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S183859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413817PMC
March 2019
2 Reads

Nonspecific immunoglobulin G is effective in preventing and treating cancer in mice.

Cancer Manag Res 2019 7;11:2073-2085. Epub 2019 Mar 7.

Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China,

Background: Previous accidental findings showed that administration of immunoglobulin G (IgG) in treating autoimmune diseases was able to inhibit cancers that happened to grow in these patients. However, such treatment has not been used to treat cancer patients clinically. The mechanism and optimal dosages of this treatment have not been established. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S188172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410752PMC
March 2019
2 Reads

is a critical oncogenic driver and contributes to epithelial-mesenchymal transition in papillary thyroid carcinoma.

Cancer Manag Res 2019 6;11:2059-2072. Epub 2019 Mar 6.

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, People's Republic of China,

Background: Growing evidence has indicated that the (), frequently deregulated in almost all tumor types tested, acted as a pivotal contributor to both cancer initiation and progression. However, the role of in human papillary thyroid carcinoma (PTC) remains controversial. The aim of the study was to investigate the expression and potential function of in human PTC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411319PMC
March 2019
2 Reads

Cervical cancer in women aged 25 years or younger: a retrospective study.

Cancer Manag Res 2019 6;11:2051-2058. Epub 2019 Mar 6.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China,

Purpose: The incidence of cervical cancer in young women is increasing. This study aimed to analyze the clinicopathological characteristics, treatment, and prognoses of women aged ≤25 years with cervical cancer.

Patients And Methods: Medical record data of 60 cervical cancer patients aged ≤25 years treated at Peking Union Medical College Hospital between January 1986 and December 2017 were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411317PMC
March 2019
1 Read

MicroRNA-21 and microRNA-30c as diagnostic biomarkers for prostate cancer: a meta-analysis.

Cancer Manag Res 2019 6;11:2039-2050. Epub 2019 Mar 6.

Department of Clinical Laboratory, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, China,

Background: Prostate cancer (PCa) is the second leading cause of cancer death in men. Several articles have reported that microRNA-21 (miR-21) and microRNA-30c (miR-30c) have diagnostic values for PCa, but the results are inconclusive. In order to precisely assess the diagnostic values of miR-21 and miR-30c for PCa, this meta-analysis is performed. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/microrna-21-and-microrna-30c-as-di
Publisher Site
http://dx.doi.org/10.2147/CMAR.S189026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411321PMC
March 2019
7 Reads

Meta-analysis of the prognostic value of for cancer patients in China.

Cancer Manag Res 2019 5;11:2027-2037. Epub 2019 Mar 5.

Department of Orthopedic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, Shandong, China,

Background: Abnormal expression of long non-coding RNA anti-differentiation noncoding RNA () can frequently be detected in cancer. Because of this, it is of vital necessity to perform a meta-analysis to clarify the value of as a prognostic marker in malignant tumors.

Methods: Related studies were retrieved from electronic databases including Web of Science, PubMed, and OVID, from inception to November 21, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S196071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407511PMC

CIRP regulates BEV-induced cell migration in gliomas.

Cancer Manag Res 2019 11;11:2015-2025. Epub 2019 Mar 11.

Stem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China,

Purpose: A better understanding of the underlying molecular mechanisms in treatment failure of bevacizumab (BEV) for malignant glioma would contribute to overcome therapeutic resistance.

Methods: Here, we used a quantitative proteomic method to identify molecular signatures of glioblastoma cell after BEV treatment by two-dimensional liquid chromatography-tandem mass spectrometry analysis and 6-plex iTRAQ quantification. Next, the function of cold-inducible RNA-binding protein (CIRP), one of the most significantly affected proteins by drug treatment, was evaluated in drug resistance of glioma cells by invasion assays and animal xenograft assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S191249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417006PMC

Outcomes of gastrectomy following upfront chemotherapy in advanced gastric cancer patients with a single noncurable factor: a cohort study.

Cancer Manag Res 2019 5;11:2007-2013. Epub 2019 Mar 5.

Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China,

Purpose: Chemotherapy is the standard care for patients with incurable advanced gastric cancer. Whether or when the addition of gastrectomy to chemotherapy improves survival of advanced gastric cancer patients with a single noncurable factor remains controversial. We aimed to evaluate the superiority of gastrectomy following chemotherapy vs chemotherapy alone regarding overall survival (OS) in these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S192570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407509PMC
March 2019
1 Read

Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma.

Cancer Manag Res 2019 4;11:1997-2006. Epub 2019 Mar 4.

Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China,

Background: As a new class of endogenous ncRNAs, circRNAs have been recently verified to be involved in the carcinogenesis and progression of human cancers. In the current study, we attempted to explore the potential function of a candidate circRNA (hsa_circ_0000337) in esophageal squamous cell carcinoma (ESCC).

Patients And Methods: The altered expression of hsa_circ_0000337 was validated in clinical samples from 48 patients with ESCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407512PMC

A novel 4-gene prognostic signature for hypermutated colorectal cancer.

Cancer Manag Res 2019 4;11:1985-1996. Epub 2019 Mar 4.

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China,

Background: Hypermutated colorectal cancer (CRC) reportedly accounts for 15%-17% of all cases of CRC. However, the proportion and number of patients with hypermutated CRC cannot be unappreciated. Additionally, therapy options for these patients differ from those for CRC patients, with a greater potential benefit from immunotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S190963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407520PMC

Second primary malignancy in patients with cholangiocarcinoma: a population-based study.

Cancer Manag Res 2019 1;11:1969-1983. Epub 2019 Mar 1.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China,

Background: A population-based estimate of risk of second primary malignancy (SPM) in patients with cholangiocarcinoma (CCA) is still lacking.

Objectives: To investigate the overall and site-specific risk of SPM in patients with CCA. To identify risk factors of SPM and further evaluate the impact of SPM on overall survival (OS) and disease specific survival (DSS) in patients with CCA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S187614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402443PMC
March 2019
1 Read

Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis.

Cancer Manag Res 2019 1;11:1959-1968. Epub 2019 Mar 1.

Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China,

Objective: Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer.

Methods: A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S193658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402436PMC

mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients.

Cancer Manag Res 2019 1;11:1945-1957. Epub 2019 Mar 1.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai, China,

Objectives: A retrospective study was performed to investigate the association between mutations and visceral pleural invasion (VPI), and evaluate the prognostic value of in resected non-small-cell lung cancer (NSCLC) patients with VPI.

Materials And Methods: Clinicopathological characteristics and follow-up information were collected from 508 consecutive patients with surgically resected stage I-III NSCLC, and mutations were detected based on real-time PCR technology. Significant results (<0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402433PMC

Pancreatic neuroendocrine tumor: prediction of the tumor grade using magnetic resonance imaging findings and texture analysis with 3-T magnetic resonance.

Cancer Manag Res 2019 4;11:1933-1944. Epub 2019 Mar 4.

Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China,

Purpose: The purpose of this study was to evaluate the performance of magnetic resonance imaging (MRI) findings and texture parameters for prediction of the histopathologic grade of pancreatic neuroendocrine tumors (PNETs) with 3-T magnetic resonance.

Patients And Methods: PNETs are classified into Grade 1 (G1), Grade 2 (G2), and Grade 3 (G3) tumors based on the Ki-67 proliferation index and the mitotic activity. A total of 77 patients with pathologically confirmed PNETs met the inclusion criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S195376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407516PMC

The role and diagnostic potential of gastrokine 1 in gastric cancer.

Cancer Manag Res 2019 1;11:1921-1931. Epub 2019 Mar 1.

Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland,

Introduction: Gene for () was identified as one of the most significant in gastric cancer and indicated as a potential therapeutic target.

Aim: The aim was a review of literature reports concerning the role and diagnostic potential of GKN1 in gastric cancer.

Materials And Methods: PubMED database was searched for sources using the following keywords: gastrokine 1/GKN1/AMP-18 and gastric cancer, , aspirin, nonsteroidal anti-inflammatory drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S194949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402446PMC
March 2019
1 Read

Pretreatment lymphocyte-to-monocyte ratio as a predictor of survival among patients with ovarian cancer: a meta-analysis.

Cancer Manag Res 2019 27;11:1907-1920. Epub 2019 Feb 27.

Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China,

Introduction: In this meta-analysis, we analyzed retrospective cohort studies that assessed the prognostic potential of the pretreatment lymphocyte-to-monocyte ratio (LMR) among patients with ovarian cancer (OC).

Materials And Methods: We comprehensively searched electronic databases, including PubMed and Embase, from inception through October 2018. A random-effects model was used to calculate pooled HRs and their 95% CIs for overall survival (OS) and progression-free survival (PFS). Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/pretreatment-lymphocyte-to-monocyt
Publisher Site
http://dx.doi.org/10.2147/CMAR.S184970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398401PMC
February 2019
5 Reads

Interferon α-inducible protein 27 is an oncogene and highly expressed in cholangiocarcinoma patients with poor survival.

Cancer Manag Res 2019 28;11:1893-1905. Epub 2019 Feb 28.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan, ROC,

Objective: Cholangiocarcinoma (CCA) is a devastating disease. Interferon α-inducible protein 27 (IFI27), originally known to involve in innate immunity, is later found to intervene in cell proliferation, leading to inventive studies regarding the role of IFI27 in cancer treatment. We aimed to investigate the role of IFI27 in CCA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S196485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400119PMC
February 2019
1 Read