3,389 results match your criteria Cancer Invest.[Journal]


Primary prophylaxis indication for docetaxel induced febrile neutropenia in elderly patients with non-small cell lung cancer.

Cancer Invest 2020 Jul 9:1-19. Epub 2020 Jul 9.

National Hospital Organization Nagoya Medical Center.

In advanced non-small cell lung cancer (NSCLC), the reported incidence of febrile neutropenia (FN) caused by docetaxel (DTX) is 10-20% in clinical trial data. However, FN incidence caused by DTX in real-world setting remains unclear. We evaluated FN incidence caused by DTX and identify risk factors of FN in real-world setting. Read More

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http://dx.doi.org/10.1080/07357907.2020.1793350DOI Listing

Investigation of human cytomegalovirus and human papillomavirus in glioma.

Cancer Invest 2020 Jul 9:1-31. Epub 2020 Jul 9.

Higher Institute of Biotechnology, Monastir University, Monastir, Tunisia.

The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, hybridization (ISH) and immunohistochemistry. Read More

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http://dx.doi.org/10.1080/07357907.2020.1793352DOI Listing

Impact of Non-steroidal Anti-inflammatory Drugs on Recurrence and Survival after Melanoma Surgery: A Cohort Study.

Cancer Invest 2020 Jul 9:1-33. Epub 2020 Jul 9.

Clinical Research Division, National Cancer Institute of Brazil (INCA), Rio de Janeiro, Brazil.

The aim of the study was to investigate if there was an association between intraoperative NSAID use and recurrence or survival. A cohort of patients who underwent sentinel lymph node biopsy for the treatment of cutaneous melanoma was retrospectively recruited. After applying inclusion and exclusion criteria, 516 were included (NSAIDs =307). Read More

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http://dx.doi.org/10.1080/07357907.2020.1793351DOI Listing

Anti-PD-1-Related Exacerbation of Interstitial Lung Disease in a Patient with Non-Small Cell Lung Cancer: A Case Presentation and Review of the Literature.

Cancer Invest 2020 Jul 2:1-7. Epub 2020 Jul 2.

Division of Hematology and Oncology, Department of Internal Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA.

Immunotherapy is standard first-line therapy for advanced non-small cell lung cancer (NSCLC) either alone or in combination with chemotherapy. Despite significant benefits, immune checkpoint inhibitors (ICI) can cause toxicities within any organ, termed immune related adverse events. Pneumonitis is a potentially life-threatening complication of ICIs. Read More

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http://dx.doi.org/10.1080/07357907.2020.1783677DOI Listing

Response  to Richard Wakeford's Letter to the Editor "Purportedly High Cancer Risk among US Sailors on Nuclear Powered Ships".

Cancer Invest 2020 Jun 23:1-2. Epub 2020 Jun 23.

Environmental Research SIA, Kurmene, Latvia.

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http://dx.doi.org/10.1080/07357907.2020.1782569DOI Listing

Purportedly High Cancer Risk among US Sailors on Nuclear-Powered Ships.

Authors:
Richard Wakeford

Cancer Invest 2020 Jun 24. Epub 2020 Jun 24.

Centre for Occupational and Environmental Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1080/07357907.2020.1782420DOI Listing

Adenosine Deaminase in Pleural Effusion and Its Relationship with Clinical Parameters in Patients with Malignant Pleural Mesothelioma.

Cancer Invest 2020 Jun 16:1-9. Epub 2020 Jun 16.

Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Pleural effusion adenosine deaminase (ADA) levels are elevated in various diseases. We investigated whether pleural effusion ADA levels differ among patients with malignant pleural mesothelioma (MPM), lung cancer (LC), and benign diseases, including tuberculous pleurisy. We examined 329 patients from February 2002 to July 2013. Read More

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http://dx.doi.org/10.1080/07357907.2020.1776313DOI Listing

Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells.

Cancer Invest 2020 Jun 8:1-7. Epub 2020 Jun 8.

Department of Neurosurgery and MUSC Brain & Spine Tumor Program, Medical University of South Carolina, Charleston, South Carolina, USA.

Meningiomas represent ∼30% of primary central nervous system (CNS) tumors. Although advances in surgery and radiotherapy have significantly improved survival, there remains an important subset of patients whose tumors have more aggressive behavior and are refractory to conventional therapy. Recent advances in molecular genetics and epigenetics suggest that this aggressive behavior may be due to the deletion of the DNA repair and tumor suppressor gene, neurofibromatosis Type 2 (NF2) mutation on chromosome 22q12, and genetic abnormalities in multiple RTKs including FGFRs. Read More

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http://dx.doi.org/10.1080/07357907.2020.1773844DOI Listing

BST2 Promotes Tumor Growth via Multiple Pathways in Hepatocellular Carcinoma.

Cancer Invest 2020 May 2;38(5):329-337. Epub 2020 Jun 2.

Department of Endocrinology and Nephrology, The Third People's Hospital of Linyi, Shandong, Linyi, China.

Bone marrow stromal antigen 2 (BST2) is a transmembrane glycoprotein and plays an essential role in innate immunity. Here we firstly found that BST2 expression was significantly elevated in hepatocellular carcinoma (HCC) tissues. High BST2 was closely related to the larger tumor size and more tumor number. Read More

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http://dx.doi.org/10.1080/07357907.2020.1769125DOI Listing

Computed Tomography Colonography Versus Standard Optical Colonoscopy for the Detection of Colorectal Polyp in Patients Who Faced Curative Surgery for Colorectal Cancer: A Diagnostic Performance Study.

Cancer Invest 2020 Jun 16:1-10. Epub 2020 Jun 16.

Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Data regarding computed tomography colonography, standard optical colonoscopy, and enhanced colonoscopy/histopathology at 1-year after surgery and at 6-month intervals for the next 2 years of 345 patients who faced curative surgery for colorectal cancer were included in this analysis. Computed tomography colonography and standard optical colonoscopy both detected 298 polyps as suspicious. With reference to enhanced colonoscopy/histopathology, sensitivities for the detection of any polyps for computed tomography colonography and standard optical colonoscopy were 0. Read More

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http://dx.doi.org/10.1080/07357907.2020.1771724DOI Listing

Lung Cancer Mortality and the Availability of Chest Computerized Tomography: A Longitudinal Nationwide Study.

Cancer Invest 2020 May 25;38(5):270-276. Epub 2020 May 25.

Hospital Cardiopulmonar, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Lung-cancer screening with chest computerized tomography (CT) is not easy to introduce in low-medium resource countries due to cost issues. We investigated whether the increasing availability of chest CT exams in Brazil, in spite of no lung-cancer screening protocol, was associated with lung-cancer death rate along 10-year follow-up. We performed regressions to estimate the rate ratio between chest CT exams and lung-cancer deaths per 10 inhabitants. Read More

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http://dx.doi.org/10.1080/07357907.2020.1768400DOI Listing

Epidemiology and Risk Factors of Osteosarcoma.

Cancer Invest 2020 May 1;38(5):259-269. Epub 2020 Jun 1.

Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma, particularly race and gender. Although diagnosed worldwide, osteosarcoma is found to be more prevalent in Africa with high numbers of cases reported in Nigeria, Uganda, and Sudan. Read More

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http://dx.doi.org/10.1080/07357907.2020.1768401DOI Listing

Centrosome Abnormalities and Polyploidy in Murine Mammary Carcinomas with Different Degrees of Hormone Responsiveness.

Cancer Invest 2020 May 25;38(5):300-309. Epub 2020 May 25.

Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.

Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. This study aimed to evaluate the relationship between polyploidy, centrosome abnormalities, and response to endocrine treatment in progestin-induced mouse mammary carcinomas. We found cells with three or more centrosomes in the polyploid tumors. Read More

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http://dx.doi.org/10.1080/07357907.2020.1766482DOI Listing

The Prognostic Significance of IGF-1R and the Predictive Risk Value of Circulating IGF-1 in Tunisian Patients with Laryngeal Carcinoma.

Cancer Invest 2020 May 1;38(5):289-299. Epub 2020 May 1.

Departement of Immuno-Histo-Cytology, Salah Azaiez Cancer Institute, Tunis, Tunisia.

The aim was to evaluate the clinical impact of IGF-1/IGF-1R in Tunisian laryngeal carcinoma. A high IGF-1R immunohistochemical expression was found in our series (81.43%). Read More

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http://dx.doi.org/10.1080/07357907.2020.1758711DOI Listing
May 2020
2.060 Impact Factor

Correction.

Authors:

Cancer Invest 2020 04 15;38(4):257-258. Epub 2020 Apr 15.

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http://dx.doi.org/10.1080/07357907.2020.1750155DOI Listing

HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy.

Cancer Invest 2020 May 27;38(5):310-328. Epub 2020 Apr 27.

Department of Tissue engineering and applied cell, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Heat shock protein 90 (HSP90), a highly and unique chaperone, presents as a double-edged sword. It plays an essential role in many physiological and pathological processes, including tumor development. The current review highlights a recent understanding of the roles of HSP90 in molecular mechanisms underlying cancer survival and progression. Read More

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http://dx.doi.org/10.1080/07357907.2020.1752227DOI Listing
May 2020
2.060 Impact Factor

Construction of a Nomogram After Using Propensity Score Matching to Reveal the Prognostic Benefit of Tumor Resection of Stage IV M1a Nonsmall Cell Lung Cancer Patients.

Cancer Invest 2020 May 24;38(5):277-288. Epub 2020 Apr 24.

Department of Respiratory and Critical Care Medicine II, The Affiliated Hospital of Southwest Medical University, Luzhuo, Sichuan Province, People's Republic of China.

The aim of this work was to determine whether tumor resection could improve the prognosis of M1a nonsmall-cell lung cancer (NSCLC) patients. We obtained patient data from the Surveillance, Epidemiology, and End Results (SEER) database and used propensity score matching (PSM) to reduce the influence of confounding variables. Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors, and the prediction results were visualized using the nomogram. Read More

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http://dx.doi.org/10.1080/07357907.2020.1753761DOI Listing

, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer.

Cancer Invest 2020 Apr 16;38(4):240-249. Epub 2020 Apr 16.

Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

We evaluated the value of , a regulator of methylation, as a biomarker for lung cancer. is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that expression is correlated with worse survival in patients with AD but not in those with SQ. knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. Read More

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http://dx.doi.org/10.1080/07357907.2020.1747483DOI Listing

Flow Cytometry Characterization of Pluripotent Transmembrane Glycoproteins on Resident Cervix Uteri Cells in Patients Screened for Cervical Cancer.

Cancer Invest 2020 Apr 13;38(4):228-239. Epub 2020 Apr 13.

Department of Advanced Medical and Surgical Sciences. U.O.C. Division of Clinical Immunology, Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT), University of Campania "Luigi Vanvitelli", Naples, Italy.

The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in cells could be a promising therapeutic target. Read More

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http://dx.doi.org/10.1080/07357907.2020.1742349DOI Listing

The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer.

Cancer Invest 2020 Apr 19;38(4):214-227. Epub 2020 Mar 19.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Read More

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http://dx.doi.org/10.1080/07357907.2020.1741604DOI Listing

Distribution of Femoral Metastases; Potential Role for Extended FDG PET/CT Scanning.

Cancer Invest 2020 Apr 5;38(4):250-256. Epub 2020 Mar 5.

Radiology and Nuclear Medicine, University of Maryland Medical School, Baltimore, Maryland, USA.

This study investigates the distribution of femoral metastases in cancer patients, specifically addressing the incidence of distal femoral metastases. PET/CT examinations routinely extend only to mid-thigh level, precluding detection of distal metastases. We found a total of 208 femoral metastases in 112 patients. Read More

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http://dx.doi.org/10.1080/07357907.2020.1735407DOI Listing

Financial Toxicity, Financial Abuse, or Financial Torture: Let's Call It What It is!

Cancer Invest 2020 Mar 4;38(3):139-142. Epub 2020 Mar 4.

Guest Editor, Cancer Investigation.

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http://dx.doi.org/10.1080/07357907.2020.1735084DOI Listing

The Composition Alteration of Respiratory Microbiota in Lung Cancer.

Cancer Invest 2020 Mar 27;38(3):158-168. Epub 2020 Feb 27.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Previous studies have reported mixed results regarding the composition of respiratory microbiota in lung cancer patients. Therefore, relying on previously published studies, we sought to estimate the relative proportion of respiratory microbiota between lung cancer cases and controls. MEDLINE, Embase, The Cochrane Library, and Web of Science online databases were systematically searched from inception up to October 14, 2019, to retrieve relevant studies. Read More

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http://dx.doi.org/10.1080/07357907.2020.1732405DOI Listing

High Cancer Risk in US Naval Personnel Serving in Nuclear Powered Ships.

Cancer Invest 2020 Mar 25;38(3):143-149. Epub 2020 Feb 25.

Environmental Research SIA, 1117 Latvian Academy of Sciences, Riga, Latvia.

The USA Defense Threat Reduction Agency provided data in 2014 on the health status, including cancer, of the 4,843 sailors on the nuclear-powered United States Ship over the 2.55-year period from May 12, 2011 to Dec 31, 2013. Also provided were data on a matched control group of 65,269 US Navy personnel. Read More

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http://dx.doi.org/10.1080/07357907.2020.1731526DOI Listing

An Unusual Presentation of HTLV-Associated Adult T-Cell Lymphoma/Leukemia - An Eye That Said It "A (T) LL".

Cancer Invest 2020 04 20;38(4):209-213. Epub 2020 Feb 20.

Consultant Otorhinolaryngologist, Yenepoya Specialty Hospital, Mangalore, India.

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http://dx.doi.org/10.1080/07357907.2020.1728298DOI Listing

Serum C-Reactive Protein Level Predicts Clinical Outcomes in Patients With Non-Small Cell Lung Cancer Harboring EGFR Mutations.

Cancer Invest 2020 Feb 5;38(2):122-129. Epub 2020 Feb 5.

Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.

The aim of this study was to assess the association of serum C-reactive protein (CRP) levels with outcomes in 81 patients with ()-mutated non-small cell lung cancer (NSCLC). Patients with high serum CRP levels had lower therapeutic responses to EGFR-tyrosine kinase inhibitors (43.8%), and shorter time to treatment failure (TTF; 5. Read More

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http://dx.doi.org/10.1080/07357907.2020.1721522DOI Listing
February 2020

Fatal Adverse Events Associated with Pembrolizumab in Cancer Patients: A Meta-Analysis.

Cancer Invest 2020 Feb 5;38(2):130-138. Epub 2020 Feb 5.

Department of Medicine, Division of Hematology & Oncology, Stony Brook University Hospital, Stony Brook, New York, USA.

Pembrolizumab as an immune checkpoint inhibitor (ICI) has emerged as an effective treatment for many cancers. It has unique immune-related adverse events (irAE) and little is known about its risk of fatal adverse events (FAEs). We conducted a meta-analysis of clinical trials to determine the incidence and risk of FAEs with pembrolizumab. Read More

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http://dx.doi.org/10.1080/07357907.2020.1721521DOI Listing
February 2020

Discriminant Analysis of Lung Cancer Using Nonlinear Clustering of Copy Numbers.

Cancer Invest 2020 Feb 30;38(2):102-112. Epub 2020 Jan 30.

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

Patient survival is not optimal for non-small cell lung cancer (NSCLC) patients, recurrence rate is high, and hence, early detection is crucial to increase the patient's survival. Gene-cancer mapping intends to discover associated genes with cancers and due to advances in high-throughput genotyping, screening for disease loci on a genome-wide scale is now possible. DNA copy numbers can potentially be used to identify cancer from normal cells in early detection of cancer. Read More

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http://dx.doi.org/10.1080/07357907.2020.1719501DOI Listing
February 2020

Amplification of Chromosome 17 Centromere (CEP17) in Breast Cancer Patients with a Result of HER2 2± by Immunohistochemistry.

Cancer Invest 2020 Feb 29;38(2):94-101. Epub 2020 Jan 29.

Algoma District Cancer Program, Sault Area Hospital, Sault Ste Marie, Canada.

Amplification of the centromeric region of chromosome 17 (CEP17) as measured by In Situ Hybridization (ISH) of the CEP17 probe is used clinically as part of the ISH assay for HER2 status determination in breast cancer. The value of amplification of CEP17 beyond its use in the HER2 ISH test has not been fully explored. A retrospective review of patients with breast cancer that had a dual probe HER2/CEP17 FISH test during an eight-year period was performed. Read More

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http://dx.doi.org/10.1080/07357907.2020.1720223DOI Listing
February 2020

Safety of Combination Immune Checkpoint Inhibitors Compared to Monotherapy; A Systematic Review and Meta-Analysis.

Cancer Invest 2020 Mar 16;38(3):150-157. Epub 2020 Feb 16.

Department of Neurology, Kasralainy Hosptial, Faculty of Medicine, Cairo University, Cairo, Egypt.

Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Read More

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http://dx.doi.org/10.1080/07357907.2020.1714053DOI Listing
March 2020
2.060 Impact Factor

Ras-Mediated Activation of NF-κB and DNA Damage Response in Carcinogenesis.

Cancer Invest 2020 Apr 6;38(4):185-208. Epub 2020 Feb 6.

Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia (A Central University), New Delhi, India.

Cancer is a multi-step process during which cells acquire mutations that eventually lead to uncontrolled cell growth and division and evasion of programmed cell death. The oncogenes such as Ras and c-Myc may be responsible in all three major stages of cancer i.e. Read More

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http://dx.doi.org/10.1080/07357907.2020.1721523DOI Listing
April 2020
2.060 Impact Factor

Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review.

Cancer Invest 2020 Mar 2;38(3):169-183. Epub 2020 Mar 2.

Postgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil.

This study aimed to determine the main single nucleotide polymorphisms (SNPs) that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. Read More

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http://dx.doi.org/10.1080/07357907.2020.1719502DOI Listing

Evaluation of a Liquid Biopsy Protocol using Ultra-Deep Massive Parallel Sequencing for Detecting and Quantifying Circulation Tumor DNA in Colorectal Cancer Patients.

Cancer Invest 2020 Feb 24;38(2):85-93. Epub 2020 Jan 24.

University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.

The identification and quantification of actionable mutations are critical for guiding targeted therapy and monitoring drug response in colorectal cancer. Liquid biopsy (LB) based on plasma cell-free DNA analysis has emerged as a noninvasive approach with many clinical advantages over conventional tissue sampling. Here, we developed a LB protocol using ultra-deep massive parallel sequencing and validated its clinical performance for detection and quantification of actionable mutations in three major driver genes ( and ). Read More

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http://dx.doi.org/10.1080/07357907.2020.1713350DOI Listing
February 2020

Clinic-Pathological Features of Breast Ductal Carcinoma with Micro-Invasion.

Cancer Invest 2020 Feb 24;38(2):113-121. Epub 2020 Jan 24.

Department of Breast Cancer Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

To investigate the differences of clinic-pathological features among ductal carcinoma in situ (DCIS), ductal carcinoma in situ with micro-invasion (DCIS-MI) and early invasive carcinoma (IDC) in stage T1. From January 2014 to December 2018, 308 cases DCIS, DCIS-MI 92 cases and 111 cases of T1a, 343 cases of T1b, and 1032 cases of T1c were investigated in a retrospective analysis. The population and clinic-pathological characteristics including age, menstrual status, surgical mode, lymph node status and molecular markers were compared in each group. Read More

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http://dx.doi.org/10.1080/07357907.2020.1715422DOI Listing
February 2020

Hsa-let-7b Suppresses Cell Proliferation by Targeting UHRF1 in Melanoma.

Cancer Invest 2020 Jan 20;38(1):52-60. Epub 2020 Jan 20.

Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, PR China.

UHRF1 promotes melanoma progression by inducing cell proliferation, and is correlated with poor prognosis of melanoma patients. However, the regulation mechanism has not been fully elaborated. Here, we detected hsa-let-7b expression and its role in melanoma. Read More

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http://dx.doi.org/10.1080/07357907.2019.1709482DOI Listing
January 2020

Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells : Repressive Effect of Extracellular Regucalcin.

Cancer Invest 2020 Jan 7;38(1):37-51. Epub 2020 Jan 7.

Laboratory of Analytical Neurosciences, Faculty of Pharmacy, Meijo University, Tempaku, Japan.

Regucalcin plays a pivotal role as a suppressor of human carcinogenesis, and downregulation of regucalcin expression may contribute to the promotion of human osteosarcoma. Overexpression of regucalcin suppressed the proliferation of Saos-2 human osteosarcoma cells and decreased the protein levels of multiple signaling components, transcription factors, and tumor suppressors. Interestingly, extracellular regucalcin repressed colony formation and proliferation of Saos-2 cells, and reduced the protein levels of multiple signaling components, cell cycle inhibitor, and various transcription factors. Read More

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http://dx.doi.org/10.1080/07357907.2019.1708924DOI Listing
January 2020

A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis.

Cancer Invest 2020 Jan 4;38(1):1-12. Epub 2019 Dec 4.

Department of Breast Disease, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, P.R. China.

The function of long noncoding RNAs (lncRNA) in breast cancer metastasis remains largely unknown. In this work, the role of HOXC-AS3 in breast cancer progression was investigated. By using Cancer Genome Atlas (TCGA) Database, we investigated the expression of HOXC-AS3 in breast cancer and explored the association between HOXC-AS3 expression and prognosis. Read More

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http://dx.doi.org/10.1080/07357907.2019.1695816DOI Listing
January 2020
2.060 Impact Factor

Development and Assessment of Nano-Technologies for Cancer Treatment: Cytotoxicity and Hyperthermia Laboratory Studies.

Cancer Invest 2020 Jan 18;38(1):61-84. Epub 2019 Dec 18.

Departamento de Química, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, México.

Cancer treatment by magnetic hyperthermia offers numerous advantages, but for practical applications many variables still need to be adjusted before developing a controlled and reproducible cancer treatment that is bio-compatible (non-damaging) to healthy cells. In this work, FeO and CoFeO were synthesized and systematically studied for the development of efficient therapeutic agents for applications in hyperthermia. The biocompatibility of the materials was further evaluated using HepG2 cells as biological model. Read More

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http://dx.doi.org/10.1080/07357907.2019.1698593DOI Listing
January 2020

Co-Expression Network Analysis Identified Genes Associated with Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma.

Cancer Invest 2020 Jan 6;38(1):13-22. Epub 2019 Dec 6.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Cancer stem cells are self-renewal cells in tumors and can produce heterogeneous tumor cells, which play an important role in the development of lung squamous cell carcinoma (LSCC). In our research, we aimed to explore the expression of genes related to LSCC stem cells. We downloaded the RNAseq data, the pathological and prognostic profiles of LSCC cases from the public database TCGA. Read More

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http://dx.doi.org/10.1080/07357907.2019.1697281DOI Listing
January 2020

Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line .

Cancer Invest 2020 Jan 16;38(1):23-36. Epub 2019 Dec 16.

Department of Orthopaedic Surgery, Loma Linda University School of Medicine, Loma Linda, CA, USA.

Recurrence or metastasis remains the major cause of poor prognosis and mortality in Osteosarcoma patients. Therefore, development of more effective therapeutic approaches is required. We showed that indomethacin, significantly induces apoptosis in MNNG/HOS cell line, which was confirmed by morphological changes, increased Annexin-V + cells and nuclear fragmentation. Read More

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http://dx.doi.org/10.1080/07357907.2019.1698592DOI Listing
January 2020

Astonishing Evolution in Oropharyngeal Cancer with Immunotherapy: A Case Report.

Cancer Invest 2019 16;37(10):531-534. Epub 2019 Oct 16.

Oncology Unit, Hopital Beaujon, Clichy, France.

Head and neck cancer is particular due to its infiltrative nature and lymphatic extension, with multidisciplinary treatment. Immunotherapy may be a brand-new therapeutic approach. We report a case of patient with advanced head and neck cancer resistant to cytotoxic treatment, with astonishing response to antibodies anti Programmed Death 1 (PD1). Read More

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http://dx.doi.org/10.1080/07357907.2019.1662032DOI Listing
December 2019

New Insights into the Epidemiology of Prostate Cancer in Ontario.

Cancer Invest 2019 4;37(10):513-523. Epub 2019 Nov 4.

Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Canada.

The epidemiology of prostate cancer (PC) continues to change. We evaluated the changes in incidence, in average age at diagnosis, and in survival from 1992 to 2015 in Ontario. We compared the cumulative incidence of PC-specific and non PC-specific mortality using two algorithms for cause of death: Method 1 assigned deaths from "other cancers" to non PC-specific causes, and Method 2 assigned these cases to PC-specific mortality. Read More

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http://dx.doi.org/10.1080/07357907.2019.1682154DOI Listing
December 2019

Oncological Outcome After Radical Prostatectomy without Pelvic Lymph Node Dissection for Localized Prostate Cancer: Follow-up Results in a Single Institution.

Cancer Invest 2019 10;37(10):524-530. Epub 2019 Oct 10.

Department of Urology, University of Occupational and Environmental Health, Kitakyushu City, Japan.

The oncological benefit of pelvic lymph node dissection (PLND) is still debatable because data on clinical outcomes of radical prostatectomy (RP) without PLND are lacking. In this study, we reported oncological outcome in consecutive 146 patients who underwent RP without PLND. Although 27% of our patients developed biochemical recurrence, the estimated 5-year overall survival rates were 100%, 96. Read More

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http://dx.doi.org/10.1080/07357907.2019.1675076DOI Listing
December 2019
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Preparation of Diphtheria and Pseudomonas Exotoxin A Immunotoxins and Evaluation of Their Cytotoxicity Effect on SK-BR-3, BT-474, and MDA-MB-231 Breast Cancer Cell Lines.

Cancer Invest 2019 10;37(10):546-557. Epub 2019 Oct 10.

Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Immunotoxin targeted therapy is a promising way of cancer therapy that is made from a toxin attached to an antibody which target a specific protein presented on cancer cells. In this study, we introduce immunotoxins comprising of truncated pseudomonas exotoxin A (PEA) and diphtheria toxin (DT) conjugated to trastuzumab. The effectiveness of 20 and 30 μg/ml immunotoxins and trastuzumab were studied on SK-BR-3 and BT-474 HER2/neu positive breast cancer cell lines by a cell death assay test. Read More

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http://dx.doi.org/10.1080/07357907.2019.1655761DOI Listing
December 2019
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Identifying Similarities and Disparities Between DNA Copy Number Changes in Cancer and Matched Blood Samples.

Cancer Invest 2019 10;37(10):535-545. Epub 2019 Oct 10.

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

Non-small cell lung cancer (NSCLC) is the first cause of cancer-related mortality for men and women in the United States. In spite of curative resection in early-stage, patient survival is not optimal and recurrence rate is high. Consequently, early detection and staging is essential to increase the patient's survival. Read More

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http://dx.doi.org/10.1080/07357907.2019.1667368DOI Listing
December 2019
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Leptomeningeal Metastases in Renal Cell Carcinoma at Initial Diagnosis: 2 Case Reports and Literature Review.

Cancer Invest 2019 4;37(9):501-505. Epub 2019 Oct 4.

Department of Medical Oncology, Institut de Cancérologie Lucien Neuwirth , Saint Priest en Jarez , France.

Leptomeningeal metastasis (LM) in solid tumors are rare, even more in renal cell carcinoma (RCC). To date there is a lack of consensual treatment modalities of leptomeningeal metastasis. Furthermore, with the improvement of outcomes and more effective systemic targeted therapies, the management of leptomeningeal metastasis becomes a real challenge. Read More

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http://dx.doi.org/10.1080/07357907.2019.1662031DOI Listing
October 2019
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Increased Risk of Hypertension with Enzalutamide in Prostate Cancer: A Meta-Analysis.

Cancer Invest 2019 1;37(9):478-488. Epub 2019 Oct 1.

Division of Hematology and Oncology, Department of Medicine, School of Medicine, State University of New York at Stony Brook , Stony Brook , NY , USA.

Hypertension is associated with enzalutamide in the treatment of prostate cancer. We performed a meta-analysis of randomized clinical trials to determine the risk of hypertension. Databases including Pubmed and Google scholar were searched to identify randomized clinical trials with enzalutamide. Read More

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http://dx.doi.org/10.1080/07357907.2019.1670203DOI Listing
October 2019
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Socioeconomic Factors Associated with Lack of Treatment in Early Stage Non-Small Cell Lung Cancer.

Cancer Invest 2019 18;37(9):506-511. Epub 2019 Sep 18.

Houston Methodist Hospital , Houston , TX , USA.

With modern radiotherapy, stage I non-small cell lung cancer (S1NSCLC) cure is extended to nonsurgical candidates. Despite this, some S1NSCLC remains untreated. We aim to identify factors associated with no treatment. Read More

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http://dx.doi.org/10.1080/07357907.2019.1666136DOI Listing
October 2019
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Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers.

Cancer Invest 2019 18;37(9):440-452. Epub 2019 Sep 18.

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague , Prague 2 , Czech Republic.

Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. Read More

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https://www.tandfonline.com/doi/full/10.1080/07357907.2019.1
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http://dx.doi.org/10.1080/07357907.2019.1663208DOI Listing
October 2019
12 Reads
2.060 Impact Factor

Circulating Cell Free Nuclear DNA, Mitochondrial DNA and Global DNA Methylation: Potential Noninvasive Biomarkers for Breast Cancer Diagnosis.

Cancer Invest 2019 13;37(9):432-439. Epub 2019 Sep 13.

Surgery Department, Faculty of Medicine, Zagazig University , Zagazig , Egypt.

Eighty seven women with benign breast lesion, 120 patients with breast cancer (BC) and one hundred controls were included in the study. Quantification of mtDNA and nDNA was done by qPCR. Global DNA methylation was measured using ELISA. Read More

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http://dx.doi.org/10.1080/07357907.2019.1663864DOI Listing
October 2019