Nonmonotonic Pathway Gene Expression Analysis Reveals Oncogenic Role of p27/Kip1 at Intermediate Dose.
Cancer Inform 2017 13;16:1176935117740132. Epub 2017 Nov 13.
Department of Computer Science, New Mexico State University, Las Cruces, NM, USA.
The mechanistic basis by which the level of p27(Kip1) expression influences tumor aggressiveness and patient mortality remains unclear. To elucidate the competing tumor-suppressing and oncogenic effects of p27(Kip1) on gene expression in tumors, we analyzed the transcriptomes of squamous cell papilloma derived from Cdkn1b nullizygous, heterozygous, and wild-type mice. We developed a novel functional pathway analysis method capable of testing directional and nonmonotonic dose response. Read More