846 results match your criteria Cancer Imaging[Journal]


Outcomes assessment in intrahepatic cholangiocarcinoma using qualitative and quantitative imaging features.

Cancer Imaging 2020 Jul 3;20(1):43. Epub 2020 Jul 3.

Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1234, New York, NY, 10029-6574, USA.

Background: To assess the performance of imaging features, including radiomics texture features, in predicting histopathologic tumor grade, AJCC stage, and outcomes [time to recurrence (TTR) and overall survival (OS)] in patients with intrahepatic cholangiocarcinoma (ICC).

Methods: Seventy-three patients (26 M/47F, mean age 63y) with pre-operative imaging (CT, n = 37; MRI, n = 21; CT and MRI, n = 15] within 6 months of resection were included in this retrospective study. Qualitative imaging traits were assessed by 2 observers. Read More

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http://dx.doi.org/10.1186/s40644-020-00323-0DOI Listing

Follow-up schedule for initial recurrent hepatocellular carcinoma after ablation based on risk classification.

Cancer Imaging 2020 Jul 1;20(1):42. Epub 2020 Jul 1.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.

Background: To date, no standard follow-up guidelines exist regarding patients receiving ablation for initial recurrent hepatocellular carcinoma (HCC). We aimed to explore whether intensive follow-up could benefit these patients.

Methods: We reviewed the clinical data of patients who received complete ablation for initial HCC recurrence after curative treatments in our institution from January 2005 to June 2017. Read More

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http://dx.doi.org/10.1186/s40644-020-00319-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329485PMC

Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease.

Cancer Imaging 2020 Jun 29;20(1):41. Epub 2020 Jun 29.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: To test the hypothesis that intraventricular ADC values can be used to determine the presence of neoplastic leptomeningeal disease (LMD).

Materials And Methods: ADC values were measured at multiple sites in the ventricular system in 32 patients with cytologically-proven LMD and 40 control subjects. Multiple linear regression analysis was used to determine the mean difference of ADCs between the LMD and control groups after adjusting for ventricle size and tumor type. Read More

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http://dx.doi.org/10.1186/s40644-020-00305-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322838PMC

MRI features predict microvascular invasion in intrahepatic cholangiocarcinoma.

Cancer Imaging 2020 Jun 23;20(1):40. Epub 2020 Jun 23.

Department of Radiology, Zhongshan Hospital, Fudan University, Fenglin Road 180# , Xuhui District, Shanghai, 200032, P.R. China.

Background: The presence of microvascular invasion (MVI) in intrahepatic cholangiocarcinoma (ICC) is a significant adverse prognostic factor. This study sought to investigate the correlation between preoperative imaging parameters and MVI in ICC.

Methods: A total of 108 patients with surgically resected single ICC tumors (34 MVI-positive and 74 MVI-negative lesions) who underwent MRI examination, including T1WI, T2WI, DWI, and dynamic enhancement imaging, were enrolled in this retrospective study. Read More

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http://dx.doi.org/10.1186/s40644-020-00318-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310524PMC

Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to F-FDG PET/CT.

Cancer Imaging 2020 Jun 16;20(1):39. Epub 2020 Jun 16.

Department of Nuclear Medicine, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian Street, Beijing, 100853, China.

Purpose: Evaluate the feasibility of fluorine-18 (F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to F FDG PET and computed tomography (CT).

Methods: The PET/CT and PET/MR imaging were sequentially performed in 30 patients with gastric cancer diagnosed by gastroscope using a single-injection-with-dual-imaging protocol. After intravenous injection of F-FDG (mean, 249 MBq), PET/CT imaging including low-dose CT was performed (mean uptake time, 47 ± 6 min), and PET/MR imaging including a T1-weighted Dixon sequence for attenuation correction and two different T2-weighted sequences was subsequently acquired (88 ± 15 min after F-FDG injection). Read More

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http://dx.doi.org/10.1186/s40644-020-00317-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298805PMC

What scans we will read: imaging instrumentation trends in clinical oncology.

Cancer Imaging 2020 Jun 9;20(1):38. Epub 2020 Jun 9.

Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Oncological diseases account for a significant portion of the burden on public healthcare systems with associated costs driven primarily by complex and long-lasting therapies. Through the visualization of patient-specific morphology and functional-molecular pathways, cancerous tissue can be detected and characterized non-invasively, so as to provide referring oncologists with essential information to support therapy management decisions. Following the onset of stand-alone anatomical and functional imaging, we witness a push towards integrating molecular image information through various methods, including anato-metabolic imaging (e. Read More

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http://dx.doi.org/10.1186/s40644-020-00312-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285725PMC

MRI-guided percutaneous thermoablation in combination with hepatic resection as parenchyma-sparing approach in patients with primary and secondary hepatic malignancies: single center long-term experience.

Cancer Imaging 2020 May 27;20(1):37. Epub 2020 May 27.

Department for Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.

Background: Combination therapy using hepatic resection (HR) and intra-operative thermal ablation is a treatment approach for patients with technically unresectable liver malignancies. The aim of this study was to investigate safety, survival and local recurrence rates for patients with technically unresectable liver tumors undergoing HR and separate percutaneous MR-guided thermoablation procedure as an alternative approach.

Methods: Data from all patients with primary or secondary hepatic malignancies treated at a single institution between 2004 and 2018 with combined HR and MR-guided percutaneous thermoablation was collected and retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s40644-020-00316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251813PMC

F-FDG PET/CT based spleen to liver ratio associates with clinical outcome to ipilimumab in patients with metastatic melanoma.

Cancer Imaging 2020 May 14;20(1):36. Epub 2020 May 14.

Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC, 3000, Australia.

Background: Immune checkpoint blockade such as ipilimumab and anti-PD1 monoclonal antibodies have significantly improved survival in advanced melanoma. Biomarkers are urgently needed as a majority of patients do not respond, despite treatment-related toxicities. We analysed pre-treatment F-fluorodeoxyglucose positron emission tomography/computerised tomography (FDG PET/CT) parameters to assess its correlation with patient outcome. Read More

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http://dx.doi.org/10.1186/s40644-020-00313-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227105PMC
May 2020
1.286 Impact Factor

Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model.

Cancer Imaging 2020 May 12;20(1):35. Epub 2020 May 12.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Anti-angiogenic treatment of glioblastoma (GBM) complicates radiologic monitoring. We evaluated magnetic resonance elastography (MRE) as an imaging tool for monitoring the efficacy of anti-VEGF treatment of GBM.

Methods: Longitudinal studies were performed in an orthotopic GBM xenograft mouse model. Read More

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http://dx.doi.org/10.1186/s40644-020-00314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218549PMC

Whole-body magnetic resonance imaging (WB-MRI) for cancer screening in asymptomatic subjects of the general population: review and recommendations.

Cancer Imaging 2020 May 11;20(1):34. Epub 2020 May 11.

Department of Oncology and Hemato-Oncology, University of Milan, Via S. Sofia, 9/1, 20122, Milan, Italy.

Background: The number of studies describing the use of whole-body magnetic resonance imaging (WB-MRI) for screening of malignant tumours in asymptomatic subjects is increasing. Our aim is to review the methodologies used and the results of the published studies on per patient and per lesion analysis, and to provide recommendations on the use of WB-MRI for cancer screening.

Main Body: We identified 12 studies, encompassing 6214 WB-MRI examinations, which provided the rates of abnormal findings and findings suspicious for cancer in asymptomatic subjects, from the general population. Read More

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http://dx.doi.org/10.1186/s40644-020-00315-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216394PMC

How to develop a meaningful radiomic signature for clinical use in oncologic patients.

Cancer Imaging 2020 May 1;20(1):33. Epub 2020 May 1.

Department of Radiology, Royal Marsden Hospital, Sutton, UK.

During the last decade, there is an increasing usage of quantitative methods in Radiology in an effort to reduce the diagnostic variability associated with a subjective manner of radiological interpretation. Combined approaches where visual assessment made by the radiologist is augmented by quantitative imaging biomarkers are gaining attention. Advances in machine learning resulted in the rise of radiomics that is a new methodology referring to the extraction of quantitative information from medical images. Read More

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http://dx.doi.org/10.1186/s40644-020-00311-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195800PMC

Development and definition of a simplified scoring system in patients with multiple myeloma undergoing stem cells transplantation on standard computed tomography: myeloma spine and bone damage score (MSBDS).

Cancer Imaging 2020 Apr 28;20(1):31. Epub 2020 Apr 28.

Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genoa, Italy.

Background: In clinical practice, there is the need to optimize imaging usage in MM patients. Accordingly, the aim of this paper was to develop a simple computed tomography (CT) scoring method for MM, able to shorten and simplify the interpretation time with good intra- and inter-reader reliability. This method, named MSBDS (Myeloma Spine and Bone Damage Score) was developed with the final aim to use standard total-body CT in the routine practice of MM centres as a complement of standard evaluations in patients undergoing stem cells transplantation. Read More

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http://dx.doi.org/10.1186/s40644-020-00306-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189746PMC

Preoperative tumor size measurement in breast cancer patients: which threshold is appropriate on computer-aided detection for breast MRI?

Cancer Imaging 2020 Apr 28;20(1):32. Epub 2020 Apr 28.

Division of Clinical Bioinformatics, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Background: Computer-aided detection (CAD) can detect breast lesions by using an enhancement threshold. Threshold means the percentage of increased signal intensity in post-contrast imaging compared to precontrast imaging. If the pixel value of the enhanced tumor increases above the set threshold, CAD provides the size of the tumor, which is calculated differently depending on the set threshold. Read More

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http://dx.doi.org/10.1186/s40644-020-00307-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189711PMC

Preoperative assessment of lymph node metastasis in Colon Cancer patients using machine learning: a pilot study.

Cancer Imaging 2020 Apr 25;20(1):30. Epub 2020 Apr 25.

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave, Suite 1600, Chicago, IL, 60611, USA.

Background: Preoperative detection of lymph node (LN) metastasis is critical for planning treatments in colon cancer (CC). The clinical diagnostic criteria based on the size of the LNs are not sensitive to determine metastasis using CT images. In this retrospective study, we investigated the potential value of CT texture features to diagnose LN metastasis using preoperative CT data and patient characteristics by developing quantitative prediction models. Read More

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http://dx.doi.org/10.1186/s40644-020-00308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183701PMC

Evaluation of CT-based radiomics signature and nomogram as prognostic markers in patients with laryngeal squamous cell carcinoma.

Cancer Imaging 2020 Apr 22;20(1):28. Epub 2020 Apr 22.

Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center, No.37, Guoxue Alley, Chengdu, 610041, People's Republic of China.

Background: The aim of this study was to evaluate the prognostic value of radiomics signature and nomogram based on contrast-enhanced computed tomography (CT) in patients after surgical resection of laryngeal squamous cell carcinoma (LSCC).

Methods: All patients (n = 136) were divided into the training cohort (n = 96) and validation cohort (n = 40). The LASSO regression method was performed to construct radiomics signature from CT texture features. Read More

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http://dx.doi.org/10.1186/s40644-020-00310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178759PMC
April 2020
1.286 Impact Factor

Distribution of brain metastases: low-risk metastasis areas may be avoided when treating with whole-brain radiotherapy.

Cancer Imaging 2020 Apr 22;20(1):29. Epub 2020 Apr 22.

Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan, People's Republic of China.

Objective: Previous work has demonstrated that metastases are not uniformly distributed across the brain. This study aims to determine there are low-risk brain metastasis (BM) areas that may be avoided during whole-brain radiotherapy (WBRT) to reduce neurocognitive toxicity.

Methods: Clinical and magnetic resonance imaging (MRI) data of 991 metastases in 192 patients with advanced cancer were analyzed retrospectively. Read More

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http://dx.doi.org/10.1186/s40644-020-00309-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178626PMC

Diffusion-weighted magnetic resonance imaging of primary cervical cancer in the detection of sub-centimetre metastatic lymph nodes.

Cancer Imaging 2020 Apr 6;20(1):27. Epub 2020 Apr 6.

Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room 406, Block K, Queen Mary Hospital, Pok Fu Lam Road, Pok Fu Lam, Hong Kong.

Background: Magnetic resonance imaging (MRI) has limited accuracy in detecting pelvic lymph node (PLN) metastasis. This study aimed to examine the use of intravoxel incoherent motion (IVIM) in classifying pelvic lymph node (PLN) involvement in cervical cancer patients.

Methods: Fifty cervical cancer patients with pre-treatment magnetic resonance imaging (MRI) were examined for PLN involvement by one subspecialist and one non-subspecialist radiologist. Read More

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http://dx.doi.org/10.1186/s40644-020-00303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137185PMC

Clinical efficacy and prognostic factors of CT-guided I brachytherapy for the palliative treatment of retroperitoneal metastatic lymph nodes.

Cancer Imaging 2020 Apr 6;20(1):25. Epub 2020 Apr 6.

Sun Yat-sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060, China.

Background: Due to the unique anatomical location of retroperitoneal metastatic lymph nodes, current treatment options are limited. This study was designed to explore the clinical efficacy and prognostic factors of CT-guided I brachytherapy for the treatment of retroperitoneal metastatic lymph nodes.

Methods: We retrospectively evaluated 92 patients received I brachytherapy for retroperitoneal metastatic lymph nodes. Read More

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http://dx.doi.org/10.1186/s40644-020-00299-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137200PMC

Evaluation of the value of the VI-RADS scoring system in assessing muscle infiltration by bladder cancer.

Cancer Imaging 2020 Apr 6;20(1):26. Epub 2020 Apr 6.

Department of Radiology, the second affiliated Hospital of Kunming Medical University, No. 374, Dianmian avenue, Wuhua district, Kunming city, 650101, Yunnan province, China.

Background: The Vesical Imaging-Reporting and Data System (VI-RADS) was created in 2018, and a 5-point VI-RADS scoring system was proposed to determine whether the muscularis of the bladder has been infiltrated by tumor tissues.

Purpose: To verify the accuracy of the VI-RADS scoring system in predicting muscle-invasive bladder cancer and to explore its value in clinical application.

Materials And Methods: A total of 220 patients with bladder cancer who underwent multiparameter magnetic resonance imaging from January 2017 to June 2019 were selected. Read More

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http://dx.doi.org/10.1186/s40644-020-00304-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137481PMC

Radiomics analysis of contrast-enhanced CT predicts lymphovascular invasion and disease outcome in gastric cancer: a preliminary study.

Cancer Imaging 2020 Apr 5;20(1):24. Epub 2020 Apr 5.

Department of Radiology, Meizhou People's Hospital, Meizhou, Guangdong, 514031, People's Republic of China.

Background: To determine whether radiomics features based on contrast-enhanced CT (CECT) can preoperatively predict lymphovascular invasion (LVI) and clinical outcome in gastric cancer (GC) patients.

Methods: In total, 160 surgically resected patients were retrospectively analyzed, and seven predictive models were constructed. Three radiomics predictive models were built from radiomics features based on arterial (A), venous (V) and combination of two phase (A + V) images. Read More

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http://dx.doi.org/10.1186/s40644-020-00302-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132895PMC

Nonprostatic diseases on PSMA PET imaging: a spectrum of benign and malignant findings.

Cancer Imaging 2020 Mar 14;20(1):23. Epub 2020 Mar 14.

Department of Radiology, Hospital Sirio-Libanes, Rua Dona Adma Jafet, 91, Sao Paulo, ZIP: 01308-050, Brazil.

PSMA PET imaging was originally used to assess biochemical recurrence of prostate cancer (PCa), but its clinical use was promptly extended to detection, staging and therapy response assessment. The expanding use of PSMA PET worldwide has also revealed PSMA ligand uptake in diverse nonprostatic diseases, which raised questions about the specificity of this imaging modality. Although not very common initially, a growing number of pathologies presenting PSMA uptake on PET have been reported in the last few years, and a proper interpretation of PSMA PET imaging findings suddenly became challenging and, to some extent, confusing. Read More

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http://dx.doi.org/10.1186/s40644-020-00300-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071711PMC

Prognostic value of 18F-FDG PET /CT metabolic parameters in patients with locally advanced pancreatic Cancer treated with stereotactic body radiation therapy.

Cancer Imaging 2020 Mar 10;20(1):22. Epub 2020 Mar 10.

Department of Radiation Oncology, Shanghai Changhai Hospital, No. 168 Changhai Road, Shanghai, 200433, China.

Background: F-FDG PET/CT metabolic parameters have been applied as prognostic factors in multi-malignancies. However, the role in locally advanced pancreatic cancer (LAPC) was not confirmed. In this study, we investigated the prognostic value of F-FDG PET/CT metabolic parameters in LAPC patients treated with stereotactic body radiation therapy (SBRT). Read More

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http://dx.doi.org/10.1186/s40644-020-00301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063714PMC

Combinative evaluation of primary tumor and lymph nodes to predict pelvic lymphatic metastasis in cervical cancer: an integrated PET-IVIM MRI study.

Cancer Imaging 2020 Mar 6;20(1):21. Epub 2020 Mar 6.

Department of Radiology, Shengjing Hospital of China Medical University, Sanhao Street No36, Heping District, Shenyang, Liaoning, PR China, 110004.

Background: The aim of this study was to evaluate the value of combining pelvic lymph node and tumor characteristics on positron emission tomography-intravoxel incoherent motion magnetic resonance (PET-IVIM MR) imaging for predicting lymph node metastasis in patients with cervical cancer, especially in those with negative lymph nodes on PET.

Methods: The medical records of 95 patients with cervical cancer who underwent surgical resection with pelvic lymph node dissection were evaluated. The patients were divided into negative and positive groups according to postoperative pathologic lymph node diagnosis, and comparisons of the PET and IVIM-derived parameters between the two groups were performed. Read More

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http://dx.doi.org/10.1186/s40644-020-00298-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060657PMC

A CT-based radiomics nomogram for differentiation of focal nodular hyperplasia from hepatocellular carcinoma in the non-cirrhotic liver.

Cancer Imaging 2020 Feb 24;20(1):20. Epub 2020 Feb 24.

Department of Radiology, the Affiliated Hospital of Qingdao University, No.16, Jiangsu Road, Qingdao, 266000, Shandong, China.

Background: The purpose of this study was to develop and validate a radiomics nomogram for preoperative differentiating focal nodular hyperplasia (FNH) from hepatocellular carcinoma (HCC) in the non-cirrhotic liver.

Methods: A total of 156 patients with FNH (n = 55) and HCC (n = 101) were divided into a training set (n = 119) and a validation set (n = 37). Radiomics features were extracted from triphasic contrast CT images. Read More

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http://dx.doi.org/10.1186/s40644-020-00297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041197PMC
February 2020

"I was seen by a radiologist, but unfortunately I can't remember the name and I still have questions. What should I do?" Radiologists should give thoughts to improve service professionalism and patient esteem.

Cancer Imaging 2020 Feb 13;20(1):18. Epub 2020 Feb 13.

Department of Radiology, Paracelsus Medical University, Salzburg, Austria.

Background: The aim of the study is to investigate how well patients remember the radiologist's name after a radiological examination, and whether giving the patient a business card improves the patient's perception of the radiologist's professionalism and esteem.

Methods: In this prospective and randomized two-centre study, a total of 141 patients with BI-RADS 1 and 2 scores were included. After screening examination comprising mammography and ultrasound by a radiologist, 71 patients received a business card (group 1), while 70 received no business card (group 2). Read More

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http://dx.doi.org/10.1186/s40644-020-0292-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020583PMC
February 2020

Resectable pancreatic ductal adenocarcinoma: association between preoperative CT texture features and metastatic nodal involvement.

Cancer Imaging 2020 Feb 10;20(1):17. Epub 2020 Feb 10.

Department of Nuclear Medicine, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, 197 Ruijin Er Road, Shanghai, 200025, NO, China.

Background: To explore the relationship between the lymph node status and preoperative computed tomography images texture features in pancreatic cancer.

Methods: A total of 155 operable pancreatic cancer patients (104 men, 51 women; mean age 63.8 ± 9. Read More

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http://dx.doi.org/10.1186/s40644-020-0296-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011565PMC
February 2020

Does the application of diffusion weighted imaging improve the prediction of survival in patients with resected brain metastases? A retrospective multicenter study.

Cancer Imaging 2020 Feb 7;20(1):16. Epub 2020 Feb 7.

Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.

Background: Brain metastases are common in clinical practice. Many clinical scales exist for predicting survival and hence deciding on best treatment but none are individualised and none use quantitative imaging parameters. A multicenter study was carried out to evaluate the prognostic utility of a simple diffusion weighted MRI parameter, tumor apparent diffusion coefficient (ADC). Read More

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http://dx.doi.org/10.1186/s40644-020-0295-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006156PMC
February 2020

Meningioma in mature cystic teratoma of the ovary: clinical and computed tomography findings.

Cancer Imaging 2020 Feb 5;20(1):15. Epub 2020 Feb 5.

Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

Background: Mature cystic teratoma (MCT) with meningioma of the ovary is a very rare benign tumor. There is only 3 reports of this disease until June 2019. The aim of the present study was to describe a ovarian mature cystic teratoma containing meningioma and nests of neuroblasts in a 15-year-old girl. Read More

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http://dx.doi.org/10.1186/s40644-020-0291-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003339PMC
February 2020

Transcatheter arterial chemoembolization combined with simultaneous DynaCT-guided microwave ablation in the treatment of small hepatocellular carcinoma.

Cancer Imaging 2020 Jan 30;20(1):13. Epub 2020 Jan 30.

Department of Interventional Radiology, The Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Luzhou, 646000, China.

Purpose: To evaluate the method and effectiveness of transcatheter arterial chemoembolization (TACE) combined with simultaneous DynaCT-guided Microwave ablation (MWA) for the treatment of small hepatocellular carcinoma (SHCC).

Materials And Methods: From June 2015 to May 2017, a total of 28 consecutive patients with SHCC received single treatment of TACE and 23 subjects received a combination treatment of TACE with simultaneous DynaCT-guided MWA. Following 1 month of treatment, the tumor response was assessed using the mRECIST criteria and the outcomes were analyzed including intervention-associated complications, changes in liver function, imaging response, and progression-free survival (PFS). Read More

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http://dx.doi.org/10.1186/s40644-020-0294-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993318PMC
January 2020

Role of whole-body MRI for treatment response assessment in multiple myeloma: comparison between clinical response and imaging response.

Cancer Imaging 2020 Jan 30;20(1):14. Epub 2020 Jan 30.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Whole-body MRI (WB-MRI) including diffusion-weighted image (DWI) have been widely used in patients with multiple myeloma. However, evidence for the value of WB-MRI in the evaluation of treatment response remains sparse. Therefore, we evaluated the role of WB-MRI in the response assessment. Read More

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http://dx.doi.org/10.1186/s40644-020-0293-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993415PMC
January 2020

Contrast-enhanced CT radiomics for predicting lymph node metastasis in pancreatic ductal adenocarcinoma: a pilot study.

Cancer Imaging 2020 Jan 30;20(1):12. Epub 2020 Jan 30.

Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, 400038, China.

Background: We developed a computational model integrating clinical data and imaging features extracted from contrast-enhanced computed tomography (CECT) images, to predict lymph node (LN) metastasis in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: This retrospective study included 159 patients with PDAC (118 in the primary cohort and 41 in the validation cohort) who underwent preoperative contrast-enhanced computed tomography examination between 2012 and 2015. All patients underwent surgery and lymph node status was determined. Read More

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http://dx.doi.org/10.1186/s40644-020-0288-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993448PMC
January 2020

Early metabolic response of breast cancer to neoadjuvant endocrine therapy: comparison to morphological and pathological response.

Cancer Imaging 2020 Jan 28;20(1):11. Epub 2020 Jan 28.

Department of Nuclear Medicine, Institut Curie-Saint-Cloud, 92210, Saint-Cloud, France.

Background: Neoadjuvant endocrine therapy (NET) has shown efficacy in terms of clinical response and surgical outcome in postmenopausal patients with estrogen receptor-positive / HER2-negative breast cancer (ER+/HER2- BC) but monitoring of tumor response is challenging. The aim of the present study was to investigate the value of an early metabolic response compared to morphological and pathological responses in this population.

Methods: This was an ancillary study of CARMINA 02, a phase II clinical trial evaluating side-by-side the efficacy of 4 to 6 months of anastrozole or fulvestrant. Read More

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http://dx.doi.org/10.1186/s40644-020-0287-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986018PMC
January 2020

PSMA PET for primary lymph node staging of intermediate and high-risk prostate cancer: an expedited systematic review.

Cancer Imaging 2020 Jan 23;20(1):10. Epub 2020 Jan 23.

Department of Nuclear Medicine and Clinical Cancer Research Centre, Aalborg University Hospital, Hobrovej 18-22, DK-9100, Aalborg, Denmark.

Background: PSMA PET is a promising method for primary lymph node staging in prostate cancer. However, recent systematic reviews have identified only a limited number of studies with histopathology as a reference test.

Methods: A systematic search was performed in PubMed and the Cochrane Library. Read More

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http://dx.doi.org/10.1186/s40644-020-0290-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979382PMC
January 2020

Intravoxel incoherent motion and ADC measurements for differentiating benign from malignant thyroid nodules: utilizing the most repeatable region of interest delineation at 3.0 T.

Cancer Imaging 2020 Jan 22;20(1). Epub 2020 Jan 22.

Philips Healthcare, Shatin, New Territories, Hong Kong, China.

Background: There is a growing need for a reproducible and effective imaging method for the quantitative differentiation of benign from malignant thyroid nodules. This study aimed to investigate the performances of intravoxel incoherent motion (IVIM) parameters and the apparent diffusion coefficient (ADC) in differentiating malignant from benign thyroid nodules derived from the most repeatable region of interest (ROI) delineation.

Methods: Forty-three patients with 46 pathologically confirmed thyroid nodules underwent diffusion-weighted imaging (DWI) with 8 b values. Read More

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http://dx.doi.org/10.1186/s40644-020-0289-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977258PMC
January 2020

A Delta-radiomics model for preoperative evaluation of Neoadjuvant chemotherapy response in high-grade osteosarcoma.

Cancer Imaging 2020 Jan 14;20(1). Epub 2020 Jan 14.

Musculoskeletal Tumor Center, Department of Orthopaedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, Hangzhou, China.

Background: The difficulty of assessment of neoadjuvant chemotherapeutic response preoperatively may hinder personalized-medicine strategies that depend on the results from pathological examination.

Methods: A total of 191 patients with high-grade osteosarcoma (HOS) were enrolled retrospectively from November 2013 to November 2017 and received neoadjuvant chemotherapy (NCT). A cutoff time of November 2016 was used to divide the training set and validation set. Read More

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http://dx.doi.org/10.1186/s40644-019-0283-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958668PMC
January 2020

The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models.

Cancer Imaging 2020 Jan 14;20(1). Epub 2020 Jan 14.

Department of Radiology, The Second Affiliated Hospital of Zhengzhou University, No. 2 Jingba Avenue, Zhengzhou, 450014, Henan Province, China.

Background: Diffusion weighted imaging(DWI) mode mainly includes intravoxel incoherent motion (IVIM), stretched exponential model (SEM) and Gaussian diffusion model, but it is still unclear which mode is the most valuable in predicting the response to radiochemotherapy for cervical cancer. This study aims to compare the values of three mathematical models in predicting the response to synchronous radiochemotherapy for cervical cancer.

Methods: Eighty-four patients with cervical cancer were enrolled into this study. Read More

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http://dx.doi.org/10.1186/s40644-019-0285-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961298PMC
January 2020
1.286 Impact Factor

Quantification of tumor burden in multiple myeloma by atlas-based semi-automatic segmentation of WB-DWI.

Cancer Imaging 2020 Jan 13;20(1). Epub 2020 Jan 13.

Computational Clinical Imaging Group, Champalimaud Foundation, Centre for the Unknown, Av. Brasília, Doca de Pedrouços, 1400-038, Lisbon, Portugal.

Background: Whole-body diffusion weighted imaging (WB-DWI) has proven value to detect multiple myeloma (MM) lesions. However, the large volume of imaging data and the presence of numerous lesions makes the reading process challenging. The aim of the current study was to develop a semi-automatic lesion segmentation algorithm for WB-DWI images in MM patients and to evaluate this smart-algorithm (SA) performance by comparing it to the manual segmentations performed by radiologists. Read More

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http://dx.doi.org/10.1186/s40644-020-0286-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958755PMC
January 2020
1.286 Impact Factor

Development and validation of a nomogram based on CT images and 3D texture analysis for preoperative prediction of the malignant potential in gastrointestinal stromal tumors.

Cancer Imaging 2020 Jan 13;20(1). Epub 2020 Jan 13.

Department of Radiology, Fudan University Shanghai Cancer Center, 270 Dong' an Road, Shanghai, 200032, China.

Background: Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the digestive system, are treated varyingly according to the malignancy. The purpose of this study is to develop and validate a nomogram for preoperative prediction of the malignant potential in patients with GIST.

Methods: A total of 440 patients with pathologically confirmed GIST after surgery in our hospital from January 2011 to July 2019 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s40644-019-0284-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958787PMC
January 2020
1.286 Impact Factor

F-FDG PET/CT imaging findings in anaplastic large cell lymphoma, a rare subtype of lymphoma.

Cancer Imaging 2020 Jan 10;20(1). Epub 2020 Jan 10.

Nanfang PET Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, Guangdong Province, China.

Objective: To investigate the F-FDG PET/CT imaging manifestations for anaplastic large cell lymphoma (ALCL), a rare subtype of T/NK cell lymphoma.

Methods: Fifty patients with ALCL, including 32 anaplastic lymphoma kinase (ALK)-positive patients and 18 ALK-negative patients, were enrolled. The positive detection, maximal standardized uptake value (SUV), and distribution of nodal and extranodal involvement were recorded and analysed. Read More

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http://dx.doi.org/10.1186/s40644-019-0278-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954597PMC
January 2020

Utility of diffusion weighted imaging with the quantitative apparent diffusion coefficient in diagnosing residual or recurrent hepatocellular carcinoma after transarterial chemoembolization: a meta-analysis.

Cancer Imaging 2020 Jan 6;20(1). Epub 2020 Jan 6.

First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China.

Background: Accurate and early diagnosis of residual tumors or intrahepatic recurrences after TACE is critically needed for determining the success of treatments and for guiding subsequent therapeutic planning. This meta-analysis was performed to assess the efficacy of diffusion weighted imaging (DWI) with the quantitative apparent diffusion coefficient (ADC) value in diagnosing residual or recurrent hepatocellular carcinoma after transarterial chemoembolization (TACE).

Materials And Methods: A comprehensive literature search of PubMed, Embase, Web of Science, Scopus and the Cochrane Library database, from inception to July 2019, was conducted to select original studies on diagnosing residual or recurrent HCCs after TACE using DWI sequence with its ADC value. Read More

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http://dx.doi.org/10.1186/s40644-019-0282-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945501PMC
January 2020

iRECIST: how to do it.

Cancer Imaging 2020 Jan 3;20(1). Epub 2020 Jan 3.

Department of Radiology, New York Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Background: iRECIST for the objective monitoring of immunotherapies was published by the official RECIST working group in 2017.

Main Body: Immune-checkpoint inhibitors represent one of the most important therapy advancements in modern oncology. They are currently used for treatment of multiple malignant diseases especially at advanced, metastatic stages which were poorly therapeutically accessible in the past. Read More

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http://dx.doi.org/10.1186/s40644-019-0281-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942293PMC
January 2020

Contrast-enhanced ultrasound findings of adult renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma.

Cancer Imaging 2019 Dec 31;20(1). Epub 2019 Dec 31.

Department of Ultrasound, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China.

Background: To investigate the contrast-enhanced ultrasound (CEUS) findings of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE3) in adult patients by comparison with those of clear cell RCC (ccRCC) and papillary RCC (pRCC). Read More

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http://dx.doi.org/10.1186/s40644-019-0268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938633PMC
December 2019

Superb microvascular imaging technique in depicting vascularity in focal liver lesions: more hypervascular supply patterns were depicted in hepatocellular carcinoma.

Cancer Imaging 2019 Dec 30;19(1):92. Epub 2019 Dec 30.

Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, 300000, China.

Purpose: To investigate the capacity of Superb Microvascular Imaging (SMI) to detect microvascular details and to explore the different SMI features in various focal liver lesions (FLLs) and the correlation between SMI and microvessel density (MVD).

Method: Eighty-three liver lesions were enrolled in our study, including 35 hepatocellular carcinomas (HCCs) and 48 non-HCCs. All patients underwent color Doppler flow imaging (CDFI) and SMI examination and were categorized into subgroups according to Adler semiquantitative grading (grade 0-3) or the microvascular morphologic patterns (pattern a-f). Read More

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http://dx.doi.org/10.1186/s40644-019-0277-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937684PMC
December 2019

Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer.

Cancer Imaging 2019 Dec 26;19(1):91. Epub 2019 Dec 26.

Department of Breast Surgery, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

Background: In patients who have had axillary nodal metastasis diagnosed prior to neoadjuvant chemotherapy for breast cancer, there is little consensus on how to manage the axilla subsequently. The aim of this study was to explore whether a combination of breast magnetic resonance imaging (MRI) assessed response and primary tumour pathology factors could identify a subset of patients that might be spared axillary node clearance.

Methods: A retrospective data analysis was performed of patients with core biopsy-proven axillary nodal metastasis prior to commencement of neoadjuvant chemotherapy (NAC) who had subsequent axillary node clearance (ANC) at definitive breast surgery. Read More

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http://dx.doi.org/10.1186/s40644-019-0279-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933687PMC
December 2019

The effects of volume of interest delineation on MRI-based radiomics analysis: evaluation with two disease groups.

Cancer Imaging 2019 Dec 21;19(1):89. Epub 2019 Dec 21.

School of Biomedical Engineering, Southern Medical University, No.1023 Shatai Road, Baiyun District, Guangzhou, 510515, Guangdong, China.

Background: Manual delineation of volume of interest (VOI) is widely used in current radiomics analysis, suffering from high variability. The tolerance of delineation differences and possible influence on each step of radiomics analysis are not clear, requiring quantitative assessment. The purpose of our study was to investigate the effects of delineation of VOIs on radiomics analysis for the preoperative prediction of metastasis in nasopharyngeal carcinoma (NPC) and sentinel lymph node (SLN) metastasis in breast cancer. Read More

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http://dx.doi.org/10.1186/s40644-019-0276-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925418PMC
December 2019

Comparison of biparametric and multiparametric MRI in the diagnosis of prostate cancer.

Cancer Imaging 2019 Dec 21;19(1):90. Epub 2019 Dec 21.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No.1, Wangfujing Street, Dongcheng District, Beijing, 100730, China.

Purpose: To compare the diagnostic accuracy of biparametric MRI (bpMRI) and multiparametric MRI (mpMRI) for prostate cancer (PCa) and clinically significant prostate cancer (csPCa) and to explore the application value of dynamic contrast-enhanced (DCE) MRI in prostate imaging.

Methods And Materials: This study retrospectively enrolled 235 patients with suspected PCa in our hospital from January 2016 to December 2017, and all lesions were histopathologically confirmed. The lesions were scored according to the Prostate Imaging Reporting and Data System version 2 (PI-RADS V2). Read More

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http://dx.doi.org/10.1186/s40644-019-0274-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925429PMC
December 2019

Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist.

Cancer Imaging 2019 Dec 19;19(1):88. Epub 2019 Dec 19.

Department of Physics, University of Oslo, P.O. Box 1048 Blindern, 0316, Oslo, Norway.

Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) may be used to depict tumour vascular structure and for therapy response assessment in various tumour sites. The purpose of the current work is to examine whether ultra-early changes in tumour physiology following cytotoxic treatment with doxorubicin and liver X receptor (LXR) agonist GW3965 are detectable by DCE-MRI.

Methods: 36 female, athymic nude foxn1nu mice with bilaterally implanted breast cancer xenografts (17 with ER-positive HBCx34, 19 with triple-negative HBCx39) were randomised in the following treatment groups; control, GW3965 (40 mg/kg p. Read More

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http://dx.doi.org/10.1186/s40644-019-0280-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924064PMC
December 2019

Use of percutaneous microwave ablation for the treatment of bone tumors: a retrospective study of clinical outcomes in 47 patients.

Cancer Imaging 2019 Dec 18;19(1):87. Epub 2019 Dec 18.

Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, 168 Donghu Street, Wuchang District, Wuhan, 430071, Hubei, People's Republic of China.

Objective: The present study aimed to evaluate the short-term clinical performance and safety of percutaneous microwave ablation (MWA) techniques for the treatment of bone tumors.

Methods: This single-institution retrospective study investigated 47 cases of bone tumors treated by MWA from June 2015 to June 2018. The study included 26 patients (55. Read More

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http://dx.doi.org/10.1186/s40644-019-0275-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918630PMC
December 2019

High negative predictive value of 68Ga PSMA PET-CT for local lymph node metastases in high risk primary prostate cancer with histopathological correlation.

Cancer Imaging 2019 Dec 11;19(1):86. Epub 2019 Dec 11.

Department of Urology, Campbelltown Hospital, Sydney, Australia.

Background: Current guidelines highlight the importance of accurate staging in the management and prognostication of high risk primary prostate cancer. Conventional radiologic imaging techniques are insufficient to reliably detect lymph node metastases in prostate cancer. Despite promising results, there is limited published data on the diagnostic accuracy of PSMA PET-CT to assess local nodal metastases prior to radical prostatectomy. Read More

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http://dx.doi.org/10.1186/s40644-019-0273-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907253PMC
December 2019
1.286 Impact Factor

RECIST and CHOI criteria in the evaluation of tumor response in patients with metastatic colorectal cancer treated with regorafenib, a prospective multicenter study.

Cancer Imaging 2019 Dec 9;19(1):85. Epub 2019 Dec 9.

GERCOR (Groupe Cooperateur Multidisciplinaire en Oncologie), 151 rue du Faubourg Saint Antoine, 75011, Paris, France.

Background: To evaluate the objective response rate (ORR) at 2 months of treatment with regorafenib according to RECIST 1.1, Choi, and modified Choi (mChoi) criteria in patients with metastatic colorectal cancer (mCRC).

Methods: Baseline and 2-month contrast-enhanced computed-tomography (CECT) scans of 55 patients with mCRC, prospectively enrolled in phase II TEXCAN trial, were centrally assessed. Read More

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http://dx.doi.org/10.1186/s40644-019-0271-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902493PMC
December 2019
1.286 Impact Factor