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    42 results match your criteria Cancer Growth and Metastasis [Journal]

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    CD133 Promotes Adhesion to the Ovarian Cancer Metastatic Niche.
    Cancer Growth Metastasis 2018 9;11:1179064418767882. Epub 2018 Apr 9.
    Harper Cancer Research Institute, South Bend, IN, USA.
    Cancer stem cells (CSCs) are an attractive therapeutic target due to their predicted role in both metastasis and chemoresistance. One of the most commonly agreed on markers for ovarian CSCs is the cell surface protein CD133. CD133+ ovarian CSCs have increased tumorigenicity, resistance to chemotherapy, and increased metastasis. Read More

    The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
    Cancer Growth Metastasis 2018 9;11:1179064418761639. Epub 2018 Mar 9.
    Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, DE, USA.
    In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the interactions of tumor cells with their microenvironment. Recent technological advances in planning and delivery of external beam radiotherapy have allowed delivery of larger doses per fraction (hypofractionation) while minimizing dose to normal tissues with higher precision. The effects of radiation on the tumor microenvironment vary with dose and fractionation schedule. Read More

    Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.
    Cancer Growth Metastasis 2017 18;10:1179064417730559. Epub 2017 Sep 18.
    Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany.
    In patients with peritoneal carcinomatosis cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a promising treatment strategy. Here, we studied the role of hyperthermic chemotherapy on heat shock protein (HSP) expression and induction of tumor cell death and survival. HSP27, HSP70, and HSP90 combined with effects on tumor cell proliferation and chemosensitivity were analyzed in human colon cancer. Read More

    Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis.
    Cancer Growth Metastasis 2017 21;10:1179064417745539. Epub 2017 Dec 21.
    Laboratory of Tumor and Development Biology, GIGA-Research (Groupe Interdisciplinaire de Génoprotéomique Appliquée-Recherche)-GIGA-Cancer, University of Liège and CHU of Liège, Liège, Belgium.
    Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-PGP (-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma. In mice exposed to cigarette smoke or lipopolysaccharide, lung neutrophilic inflammation produces increased levels of MMP-9 (matrix metalloproteinase 9) that contributes to collagen breakdown and allows the release of ac-PGP tripeptides. Read More

    Neutrophil-Derived Interleukin 16 in Premetastatic Lungs Promotes Breast Tumor Cell Seeding.
    Cancer Growth Metastasis 2017 27;10:1179064417738513. Epub 2017 Oct 27.
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium.
    The premetastatic niche in distant organs prior to metastatic cell arrival emerged as an important step in the metastatic cascade. However, molecular mechanisms underlying this process are still poorly understood. In particular, whether neutrophil recruitment at a premetastatic stage promotes or inhibits metastatic cell seeding has to be clarified. Read More

    Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex.
    Cancer Growth Metastasis 2017 19;10:1179064417713197. Epub 2017 Jun 19.
    Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA, USA.
    The WASF3 gene facilitates the metastatic phenotype, and its inactivation leads to suppression of invasion and metastasis regardless of the genetic background of the cancer cell. This reliance on WASF3 to facilitate metastasis suggests that targeting its function could serve as an effective strategy to suppress metastasis. WASF3 stability and function are regulated by the WASF Regulatory Complex (WRC) of proteins, particularly CYFIP1 and NCKAP1. Read More

    Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple Opponents.
    Cancer Growth Metastasis 2017 15;10:1179064417709287. Epub 2017 May 15.
    Department of Biology, San Diego State University, CA, USA.
    Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and one of the most lethal human cancers. Inflammation is a critical component in PDAC initiation and progression. Inflammation also contributes to the aggressiveness of PDAC indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to enhanced resistance to chemotherapy and poor survival rates. Read More

    In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes.
    Cancer Growth Metastasis 2017 10;10:1179064417696070. Epub 2017 Mar 10.
    Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD, USA.
    Glutathione disulfide (GSSG) is an endogenous peptide and the oxidized form of glutathione. The impacts of GSSG on cell function/dysfunction remain largely unexplored due to a lack of method to specifically increase intracellular GSSG. We recently developed GSSG liposomes that can specifically increase intracellular GSSG. Read More

    In Vitro and In Vivo Antimetastatic Effect of Glutathione Disulfide Liposomes.
    Cancer Growth Metastasis 2017 8;10:1179064417695255. Epub 2017 Mar 8.
    Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD, USA.
    Cancer metastasis is the major cause of cancer mortality. Despite extensive research efforts, effective treatment for cancer metastasis is still lacking. Cancer metastasis involves 4 essential steps: cell detachment, migration, invasion, and adhesion. Read More

    Prognostic Value of Her2/neu Expression in Gastrointestinal Stromal Tumors: Immunohistochemical Study.
    Cancer Growth Metastasis 2017 16;10:1179064417690543. Epub 2017 Feb 16.
    Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Background: Gastrointestinal stromal tumor (GIST) is a relatively rare type of neoplasms. In Egypt, it represents 2.5% of gastrointestinal tumors and 0. Read More

    First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors.
    Cancer Growth Metastasis 2016 2;9:9-20. Epub 2016 Aug 2.
    New York Presbyterian-Weill Cornell Medical Center, New York, NY, USA.
    Purpose: Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs) release factors, suppressing the growth of cancer cells and prolonging survival in spontaneous or induced tumor animals, mediated, in part, by increased levels of myocyte-enhancing factor (MEF2D) via EGFR-and AKT-signaling pathways. The primary objective of this study was to determine the safety of RMBs in advanced, treatment-resistant metastatic cancers, and then its efficacy (survival), which is the secondary objective.

    Methods: Thirty-one patients underwent up to four intraperitoneal implantations of RMBs (8 or 16 macrobeads/kg) via laparoscopy in this single-arm trial (FDA BB-IND 10091; NCT 00283075). Read More

    Impact of Transfusion on Cancer Growth and Outcome.
    Cancer Growth Metastasis 2016 13;9:1-8. Epub 2016 Mar 13.
    Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
    For many years, transfusion of allogeneic red blood cells, platelet concentrates, and plasma units has been part of the standard therapeutic arsenal used along the surgical and nonsurgical treatment of patients with malignancies. Although the benefits of these blood products are not a matter of debate in specific pathological conditions associated with life-threatening low blood cell counts or bleeding, increasing clinical evidence is nevertheless suggesting that deliberate transfusion of these blood components may actually lead to negative clinical outcomes by affecting patient's immune defense, stimulating tumor growth, tethering, and dissemination. Rigorous preclinical and clinical studies are needed to dimension the clinical relevance, benefits, and risks of transfusion of blood components in cancer patients and understand the amplitude of problems. Read More

    Synergistic Effects of Crizotinib and Temozolomide in Experimental FIG-ROS1 Fusion-Positive Glioblastoma.
    Cancer Growth Metastasis 2015 1;8:51-60. Epub 2015 Dec 1.
    Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA. ; Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
    Glioblastoma (GB) is the most common malignant brain tumor. Drug resistance frequently develops in these tumors during chemotherapy. Therefore, predicting drug response in these patients remains a major challenge in the clinic. Read More

    Cancer Metastases: Early Dissemination and Late Recurrences.
    Cancer Growth Metastasis 2015 29;8:43-9. Epub 2015 Nov 29.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Background: Metastatic cells from a primary tumor can occur before the primary cancer is detected. Metastatic cells can also remain in the patient for many years after removal of the primary tumor without proliferating. These dormant malignant cells can awaken and cause recurrent disease decades after the primary treatment. Read More

    Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
    Cancer Growth Metastasis 2015 19;8(Suppl 1):95-113. Epub 2015 Oct 19.
    Department of Cellular & Molecular Medicine, University of Arizona, Tucson, AZ, USA.
    Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies, characterized by the local invasion into surrounding tissues and early metastasis to distant organs. Oncogenic mutations of the K-RAS gene occur in more than 90% of human pancreatic cancers. The goal of this study was to investigate the functional significance and downstream effectors of mutant K-RAS oncogene in the pancreatic cancer invasion and metastasis. Read More

    Current State of Animal (Mouse) Modeling in Melanoma Research.
    Cancer Growth Metastasis 2015 6;8(Suppl 1):81-94. Epub 2015 Oct 6.
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
    Despite the considerable progress in understanding the biology of human cancer and technological advancement in drug discovery, treatment failure remains an inevitable outcome for most cancer patients with advanced diseases, including melanoma. Despite FDA-approved BRAF-targeted therapies for advanced stage melanoma showed a great deal of promise, development of rapid resistance limits the success. Hence, the overall success rate of melanoma therapy still remains to be one of the worst compared to other malignancies. Read More

    Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.
    Cancer Growth Metastasis 2015 7;8(Suppl 1):63-80. Epub 2015 Sep 7.
    Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. ; College of Optical Sciences, University of Arizona, Tucson, AZ, USA. ; University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
    Optical coherence tomography (OCT) is a high-resolution, nondestructive imaging modality that enables time-serial assessment of adenoma development in the mouse model of colorectal cancer. In this study, OCT was utilized to evaluate the effectiveness of interventions with the experimental antitumor agent α-difluoromethylornithine (DFMO) and a nonsteroidal anti-inflammatory drug sulindac during early [chemoprevention (CP)] and late stages [chemotherapy (CT)] of colon tumorigenesis. Biological endpoints for drug interventions included OCT-generated tumor number and tumor burden. Read More

    Esophageal Cancer: Insights From Mouse Models.
    Cancer Growth Metastasis 2015 16;8(Suppl 1):37-46. Epub 2015 Aug 16.
    Department of Medicine, Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    Esophageal cancer is the eighth leading cause of cancer and the sixth most common cause of cancer-related death worldwide. Despite recent advances in the development of surgical techniques in combination with the use of radiotherapy and chemotherapy, the prognosis for esophageal cancer remains poor. The cellular and molecular mechanisms that drive the pathogenesis of esophageal cancer are still poorly understood. Read More

    Emerging and Evolving Ovarian Cancer Animal Models.
    Cancer Growth Metastasis 2015 12;8(Suppl 1):29-36. Epub 2015 Aug 12.
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine-South Bend, South Bend, IN, USA. ; Harper Cancer Research Institute, South Bend, IN, USA. ; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA. ; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA.
    Ovarian cancer (OC) is the leading cause of death from a gynecological malignancy in the United States. By the time a woman is diagnosed with OC, the tumor has usually metastasized. Mouse models that are used to recapitulate different aspects of human OC have been evolving for nearly 40 years. Read More

    Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines.
    Cancer Growth Metastasis 2015 9;8(Suppl 1):17-27. Epub 2015 Aug 9.
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
    Nonmelanoma skin cancer (NMSC) is a major health concern worldwide. With increasing numbers in high-risk groups such as organ transplant recipients and patients taking photosensitizing medications, the incidence of NMSC continues to rise. Mouse models of NMSC allow us to better understand the molecular signaling cascades involved in skin tumor development in order to identify novel therapeutic strategies. Read More

    Single and Multiple Gene Manipulations in Mouse Models of Human Cancer.
    Cancer Growth Metastasis 2015 13;8(Suppl 1):1-15. Epub 2015 Jul 13.
    Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
    Mouse models of human cancer play a critical role in understanding the molecular and cellular mechanisms of tumorigenesis. Advances continue to be made in modeling human disease in a mouse, though the relevance of a mouse model often relies on how closely it is able to mimic the histologic, molecular, and physiologic characteristics of the respective human cancer. A classic use of a genetically engineered mouse in studying cancer is through the overexpression or deletion of a gene. Read More

    Use of Animal Models in Understanding Cancer-induced Bone Pain.
    Cancer Growth Metastasis 2015 23;8(Suppl 1):47-62. Epub 2015 Aug 23.
    Department of Medical Pharmacology, University of Arizona College of Medicine, Tucson, AZ, USA.
    Many common cancers have a propensity to metastasize to bone. Although malignancies often go undetected in their native tissues, bone metastases produce excruciating pain that severely compromises patient quality of life. Cancer-induced bone pain (CIBP) is poorly managed with existing medications, and its multifaceted etiology remains to be fully elucidated. Read More

    New Insight on the Role of Plasminogen Receptor in Cancer Progression.
    Cancer Growth Metastasis 2015 29;8:35-42. Epub 2015 Jul 29.
    Cancer Biology Lab, Department of Biochemistry, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
    Objective: Plasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration, wound healing, immune response, angiogenesis, invasion and metastasis. It gets activated when plasminogen associates with its cell surface receptors. Latest information on some of the well-explored plasminogen receptors such as annexin II-S100A10, cytokeratin 8, α-enolase, plasminogen receptor (KT) (Plg-R(KT)) and histone H2B has been discussed in the present review. Read More

    Pattern Recognition Receptors in Cancer Progression and Metastasis.
    Cancer Growth Metastasis 2015 23;8:25-34. Epub 2015 Jul 23.
    Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar Road, Delhi, India.
    The innate immune system is an integral component of the inflammatory response to pathophysiological stimuli. Toll-like receptors (TLRs) and inflammasomes are the major sensors and pattern recognition receptors (PRRs) of the innate immune system that activate stimulus (signal)-specific pro-inflammatory responses. Chronic activation of PRRs has been found to be associated with the aggressiveness of various cancers and poor prognosis. Read More

    Molecular Heterogeneity in Primary Breast Carcinomas and Axillary Lymph Node Metastases Assessed by Genomic Fingerprinting Analysis.
    Cancer Growth Metastasis 2015 20;8:15-24. Epub 2015 Jul 20.
    Clinical Breast Care Project, Windber Research Institute, Windber, PA, USA.
    Molecular heterogeneity within primary breast carcinomas and among axillary lymph node (LN) metastases may impact diagnosis and confound treatment. In this study, we used short tandem repeated sequences to assess genomic heterogeneity and to determine hereditary relationships among primary tumor areas and regional metastases from 30 breast cancer patients. We found that primary carcinomas were genetically heterogeneous and sampling multiple areas was necessary to adequately assess genomic variability. Read More

    Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer.
    Cancer Growth Metastasis 2015 29;8:1-13. Epub 2015 Jan 29.
    Center for Translational Cancer Research, Helen F. Graham Cancer Center, Christiana Care Health Services, Inc., Newark, DE, USA. ; Department of Medical Laboratory Sciences, University of Delaware, Newark, DE, USA.
    The relationship between wound healing and cancer has long been recognized. The mechanisms that regulate wound healing have been shown to promote transformation and growth of malignant cells. In addition, chronic inflammation has been associated with malignant transformation in many tissues. Read More

    A Role for the Cavin-3/Matrix Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype.
    Cancer Growth Metastasis 2014 8;7:43-51. Epub 2014 Dec 8.
    Laboratoire d'Oncologie Moléculaire, Département de Chimie, Centre de Recherche BIOMED, Université du Québec à Montreal, Quebec, Canada. ; Département de Physiologie, Faculté de Médecine, Université de Montreal, Montreal, Canada.
    Caveolae are specialized cell membrane invaginations known to regulate several cancer cell functions and oncogenic signaling pathways. Among other caveolar proteins, they are characterized by the presence of proteins of the cavin family. In this study, we assessed the impact of cavin-1, cavin-2, and cavin-3 on cell migration in a human HT-1080 fibrosarcoma model. Read More

    Bone disease in multiple myeloma: pathophysiology and management.
    Cancer Growth Metastasis 2014 10;7:33-42. Epub 2014 Aug 10.
    National Institute for cellular Biotechnology, Dublin City University, Dublin, Ireland. ; Hematology Department, Mater Misericordaie University Hospital, Dublin, Ireland.
    Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM). More than 80% of MM patients suffer from destructive bony lesions, leading to pain, fractures, mobility issues, and neurological deficits. MBD is not only a main cause of disability and morbidity in MM patients but also increases the cost of management. Read More

    Systemic Platelet-activating Factor Receptor Activation Augments Experimental Lung Tumor Growth and Metastasis.
    Cancer Growth Metastasis 2014 19;7:27-32. Epub 2014 Jun 19.
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA. ; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
    Pro-oxidative stressors including cigarette smoke (CS) generate novel lipids with platelet-activated factor-receptor (PAF-R) agonistic activity mediate systemic immunosuppression, one of the most recognized events in promoting carcinogenesis. Our previous studies have established that these oxidized-PAF-R-agonists augment murine B16F10 melanoma tumor growth in a PAF-R-dependent manner because of its effects on host immunity. As CS generates PAF-R agonists, the current studies sought to determine the impact of PAF-R agonists on lung cancer growth and metastasis. Read More

    Cancer chemoprevention: current state of the art.
    Cancer Growth Metastasis 2014 10;7:19-25. Epub 2014 Jun 10.
    Biomedical Diagnostic and Therapeutic Sciences, School of Health Sciences, Oakland University, Rochester, MI, USA.
    The aim of cancer chemoprevention is disruption or delay of the molecular pathways that lead to carcinogenesis. Chemopreventive blocking and/or suppressing agents disrupt the molecular mechanisms that drive carcinogenesis such as DNA damage by reactive oxygen species, increased signal transduction to NF-κB, epigenomic deregulation, and the epithelial mesenchymal transition that leads to metastatic progression. Numerous dietary phytochemicals have been observed to inhibit the initiation phase of carcinogenesis, and therefore are useful in primary chemoprevention. Read More

    Regulation of tumor growth and metastasis: the role of tumor microenvironment.
    Cancer Growth Metastasis 2014 2;7:9-18. Epub 2014 Jun 2.
    Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
    The presence of abnormal cells with malignant potential or neoplastic characteristics is a relatively common phenomenon. The interaction of these abnormal cells with their microenvironment is essential for tumor development, protection from the body's immune or defence mechanisms, later progression and the development of life-threatening or metastatic disease. The tumor microenvironment is a collective term that includes the tumor's surrounding and supportive stroma, the different effectors of the immune system, blood platelets, hormones and other humoral factors. Read More

    TGF-β Mediated Crosstalk Between Malignant Hepatocyte and Tumor Microenvironment in Hepatocellular Carcinoma.
    Cancer Growth Metastasis 2014 23;7:1-8. Epub 2014 Mar 23.
    Advanced Molecular Science Research Centre, King George's Medical University, Lucknow, India.
    In this article, we have reviewed current literature regarding the regulation of hepatocellular carcinoma (HCC) by the interaction of malignant hepatocytes and their tissue environment through cytokine signaling, here represented by transforming growth factor-beta (TGF-β) signaling. We have discussed responses of TGF-β signaling in transition of hepatic stellate cells to myofibroblasts (MFBs), recruitment of tumor-associated macrophages (TAMs), and enrichment of tumor-associated endothelial cells (TECs). The malignant hepatocytes also secrete various factors such as platelet-derived growth factors (PDGFs), vascular endothelial growth factor (VEGF), and TGF-β. Read More

    Repopulation of ovarian cancer cells after chemotherapy.
    Cancer Growth Metastasis 2013 Feb;6:15-21
    The high mortality rate caused by ovarian cancer has not changed for the past thirty years. Although most patients diagnosed with this disease respond to cytoreductive surgery and platinum-based chemotherapy and undergo remission, foci of cells almost always escape therapy, manage to survive, and acquire the capacity to repopulate the tumor. Repopulation of ovarian cancer cells that escape front-line chemotherapy, however, is a poorly understood phenomenon. Read More

    Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells.
    Cancer Growth Metastasis 2013 28;6:1-13. Epub 2012 Jan 28.
    We have previously shown that the antiprogestin and antiglucocorticoid mifepristone inhibits the growth of ovarian cancer cells. In this work, we hypothesized that cellular stress caused by mifepristone is limited to cytostasis and that cell killing is avoided as a consequence of the persistent activity of the PI3K/Akt survival pathway.To investigate the role of this pathway in mifepristone-induced growth inhibition, human ovarian cancer cells of various histological subtypes and genetic backgrounds were exposed to cytostatic doses of mifepristone in the presence or absence of the PI3K inhibitor, LY294002. Read More

    The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer.
    Cancer Growth Metastasis 2013 27;6:61-80. Epub 2013 Nov 27.
    Spinal Biology Research Laboratory, Department of Spinal Surgery, University of Melbourne Department of Surgery, Austin Health, Heidelberg Victoria, Australia.
    Prostate cancer (PC) is one of the most common cancers arising in men and has a high propensity for bone metastasis, particularly to the spine. At this stage, it often causes severe morbidity due to pathological fracture and/or metastatic epidural spinal cord compression which, if untreated, inevitably leads to intractable pain, neurological deficit, and paralysis. Unfortunately, the underlying molecular mechanisms driving growth of secondary PC in the bony vertebral column remain largely unknown. Read More

    Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy.
    Cancer Growth Metastasis 2013 20;6:53-9. Epub 2013 Aug 20.
    Lead Evaluation and Mechanistic Biochemistry, Bristol Myers Squibb Company, Princeton, NJ.
    The link between signaling pathways and diseases suggests the importance of pathway analysis for drug discovery. This includes target identification and validation, compound mode of action and drug candidate optimization. Here, we propose to apply cell signaling pathway panel approaches for oncology drug discovery. Read More

    Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.
    Cancer Growth Metastasis 2013 8;6:35-52. Epub 2013 Aug 8.
    Martin-Luther-University Halle-Wittenberg, University Clinic and Polyclinic for Child and Adolescent Medicine, Halle, Germany.
    Curcumin, a phytochemical isolated from curcuma plants which are used as coloring ingredient for the preparation of curry powder, has several activities which suggest that it might be an interesting drug for the treatment or prevention of cancer. Curcumin targets different pathways which are involved in the malignant phenotype of tumor cells, including the nuclear factor kappa B (NFKB) pathway. This pathway is deregulated in multiple tumor entities, including Hodgkin's lymphoma (HL). Read More

    Animal cancer models of skeletal metastasis.
    Cancer Growth Metastasis 2013 1;6:23-34. Epub 2013 Aug 1.
    Spinal Biology Research Laboratory, University of Melbourne, Department of Surgery, Austin Health, Heidelberg Victoria 3084, Australia. ; Department of Spinal Surgery, Austin Health, Heidelberg Victoria 3084, Australia.
    The bony skeleton is one of the most common sites of metastatic spread of cancer and is a significant source of morbidity in cancer patients, causing pain and pathologic fracture, impaired ambulatory ability, and poorer quality of life. Animal cancer models of skeletal metastases are essential for better understanding of the molecular pathways behind metastatic spread and local growth and invasion of bone, to enable analysis of host-tumor cell interactions, identify barriers to the metastatic process, and to provide platforms to develop and test novel therapies prior to clinical application in human patients. Thus, the ideal model should be clinically relevant, reproducible and representative of the human condition. Read More

    BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis.
    Cancer Growth Metastasis 2010 Jan;2009(2):45-55
    Pancreatic adenocarcinoma is an aggressive cancer with a greater than 95% mortality rate and short survival after diagnosis. Chemotherapeutic resistance hinders successful treatment. This resistance is often associated with mutations in codon 12 of the K-Ras gene (K-Ras 12), which is present in over 90% of all pancreatic adenocarcinomas. Read More

    Molecular Imaging of Proteases in Cancer.
    Cancer Growth Metastasis 2009 Aug;2:13-27
    Proteases play important roles during tumor angiogenesis, invasion, and metastasis. Various molecular imaging techniques have been employed for protease imaging: optical (both fluorescence and bioluminescence), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron emission tomography (PET). In this review, we will summarize the current status of imaging proteases in cancer with these techniques. Read More

    Possible Mitochondria-Associated Enzymatic Role in Non-Hodgkin Lymphoma Residual Disease.
    Cancer Growth Metastasis 2008 Nov;1:3-8
    BACKGROUND: The mechanisms responsible for resistant or recurrent disease in childhood non-Hodgkin lymphoma (NHL) are not yet fully understood. A unique mechanism suggesting the role of the mitochondria as the key energy source responsible for residual cells has been assessed in the clinical setting on specimens from patients on therapy were found to have increased copies of mitochondrial DNA (mtDNA) associated with positive minimal residual disease and/or persistent disease (MRD/PD) status. The potential role of mtDNA in MRD/PD emphasizes queries into the contributions of relevant enzymatic pathways responsible for MRD/PD. Read More

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