7,726 results match your criteria Cancer Epidemiol. Biomarkers Prev.[Journal]


Heterogeneity in Trust of Cancer Information among Hispanic Adults in the United States: An Analysis of the Health Information National Trends Survey.

Cancer Epidemiol Biomarkers Prev 2020 Jul;29(7):1348-1356

Department of Community Health and Social Medicine, CUNY School of Medicine, New York, New York.

Background: Hispanics are differentially burdened by inequities in cancer outcomes. Increasing knowledge about cancer and cancer services among Hispanics may aid in reducing inequities, but little is known about what information sources are considered most effective or most trusted by this diverse population. The goal of this study was to examine heterogeneity in trust of cancer information from various media sources among U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1375DOI Listing

Selected Articles from This Issue.

Authors:

Cancer Epidemiol Biomarkers Prev 2020 Jul;29(7):1281

View Article

Download full-text PDF

Source

A Prospective Analysis of Intake of Red and Processed Meat in Relation to Pancreatic Cancer among African American Women.

Cancer Epidemiol Biomarkers Prev 2020 Jul 1. Epub 2020 Jul 1.

Slone Epidemiology Center, Boston University.

Background: African Americans have the highest incidence of pancreatic cancer of any racial/ethnic group in the US. There is evidence that consumption of red or processed meat and foods containing saturated fats may increase the risk of pancreatic cancer, but there is limited evidence in African Americans.

Methods: Utilizing the Black Women's Health Study (1995-2018), we prospectively investigated the associations of red and processed meat and saturated fats with incidence of pancreatic adenocarcinoma (n=168). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0048DOI Listing

The association of MUC16 mutation with tumor mutation burden and its prognostic implications in cutaneous melanoma.

Cancer Epidemiol Biomarkers Prev 2020 Jul 1. Epub 2020 Jul 1.

Immunology, Moffitt Cancer Center.

Background: MUC16 is a mucin marker that is frequently mutated in melanoma; but whether MUC16 mutations could be useful as a surrogate biomarker for tumor mutation burden (TMB) remains unclear.

Methods: This study rigorously evaluates the MUC16 mutation as a clinical biomarker in cutaneous melanoma by utilizing genomic and clinical data from patient samples from The Cancer Genome Atlas (TCGA) and two independent validation cohorts. We further extended the analysis to studies with patients treated with immunotherapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0307DOI Listing

Cognitive impairment in breast cancer patients before surgery: results from a CANTO cohort subgroup.

Cancer Epidemiol Biomarkers Prev 2020 Jul 1. Epub 2020 Jul 1.

GRECAN, Université de Caen, EA1772 - IFR 146 ICORE et Service d'Oncologie médicale centre François Baclesse, Centre François Baclesse.

Background: 20-30% of breast cancer patients have cognitive impairment after surgery and before adjuvant treatment, but very few studies have focused on cognition before any treatment. The present study used a subgroup of women with newly diagnosed breast cancer patients from the French cancer and toxicities (CANTO) cohort to describe cognition before any treatment in comparison to a group of healthy controls (HC).

Methods: Cognitive assessment was performed before any breast cancer treatment (surgery or neoadjuvant treatment) on women with newly diagnosed invasive stage I-III breast cancer and HC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0346DOI Listing

Telomere maintenance variants and survival after colorectal cancer: Smoking- and sex-specific associations.

Cancer Epidemiol Biomarkers Prev 2020 Jun 25. Epub 2020 Jun 25.

Public Health Sciences, Fred Hutchinson Cancer Research Center

Background: Telomeres play an important role in colorectal cancer (CRC) prognosis. Variation in telomere maintenance genes may be associated with survival after CRC diagnosis but evidence is limited. In addition, possible interactions between telomere maintenance genes and prognostic factors such as smoking and sex also remain to be investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1507DOI Listing

Association of sex hormones with risk of cancers of the pancreas, kidney and brain in the UK Biobank cohort study.

Cancer Epidemiol Biomarkers Prev 2020 Jun 24. Epub 2020 Jun 24.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine.

Background: There is some evidence to suggest that endogenous levels of sex hormones might influence the etiology of cancers of the pancreas, kidney, and brain, but epidemiological data are lacking.

Methods: We evaluated the association of circulating levels of total and free testosterone, and of sex hormone binding globulin (SHBG), with the risk of cancers of the pancreas, kidney, and brain, and of total and free estradiol with the risk of kidney cancer, in the UK Biobank cohort study (n=425,793; 225 pancreatic cancers, 749 kidney cancers, 467 brain cancers). Multivariable Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for the associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0246DOI Listing

A genetic risk score to personalize prostate cancer screening, applied to population data.

Cancer Epidemiol Biomarkers Prev 2020 Jun 24. Epub 2020 Jun 24.

Radiation Medicine and Applied Sciences, University of California, San Diego

Background: A polygenic hazard score (PHS)-the weighted sum of 54 SNP genotypes-was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.

Methods: UK population incidence data (Cancer Research UK) and data from the Cluster Randomized Trial of PSA Testing for Prostate Cancer were combined to estimate age-specific clinically significant prostate cancer incidence (Gleason≥7, stage T3-T4, PSA ≥10, or nodal/distant metastases). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1527DOI Listing

Integrative Systems Praxis for Implementation Research (INSPIRE): An implementation methodology to facilitate the global elimination of cervical cancer.

Cancer Epidemiol Biomarkers Prev 2020 Jun 19. Epub 2020 Jun 19.

Tulane School of Public Health and Tropical Medicine.

Background: The World Health Organization (WHO) has called for a systems thinking approach to health systems strengthening to increase adoption of evidence-based interventions (EBIs). The Integrative Systems Praxis for Implementation Research (INSPIRE) methodology operationalizes the WHO systems thinking framework to meet cervical cancer elimination early detection and treatment (CC-EDT) goals.

Methods: Using a systems thinking approach and grounded in the consolidated framework for implementation research, INSPIRE integrates multiple research methodologies and evaluation frameworks into a multilevel implementation strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0501DOI Listing
June 2020
4.125 Impact Factor

Genome-wide gene-diabetes and gene-obesity interaction scan in 8,255 cases and 11,900 controls from the PanScan and PanC4 Consortia.

Cancer Epidemiol Biomarkers Prev 2020 Jun 16. Epub 2020 Jun 16.

Biostatistics, The University of Texas MD Anderson Cancer Center

Background: Obesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants and diabetes/obesity have not previously been comprehensively investigated in pancreatic cancer at the genome-wide level.

Methods: We conducted a gene-environment interaction (GxE) analysis including 8,255 cases and 11,900 controls from four pancreatic cancer GWAS datasets (PanScan I-III and PanC4). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0275DOI Listing

Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers.

Cancer Epidemiol Biomarkers Prev 2020 Jun 12. Epub 2020 Jun 12.

Department of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

Background: Cotinine is the most widely used biomarker of tobacco exposure. At similar smoking levels, African Americans have higher serum cotinine than Whites. UGT2B10-catalyzed cotinine glucuronidation impacts these levels, and African Americans often have low UGT2B10 activity due to a high prevalence of a splice variant (rs2942857). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0203DOI Listing

Biomarkers and Strategy to Detect Pre-Invasive and Early Pancreatic Cancer: State of the Field and the Impact of the EDRN.

Cancer Epidemiol Biomarkers Prev 2020 Jun 12. Epub 2020 Jun 12.

Center for Cancer and Cell Biology, Van Andel Institute

Background: Patients afflicted with pancreatic ductal adenocarcinoma (PDAC) face a dismal prognosis, but headway could be made if physicians could identify the disease earlier. A compelling strategy to broaden the use of surveillance for PDAC is to incorporate molecular biomarkers in combination with clinical analysis and imaging tools.

Methods: This article summarizes the components involved in accomplishing biomarker validation and an analysis of the requirements of molecular biomarkers for disease surveillance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0161DOI Listing

Advancing Rural Cancer Control Research: National Cancer Institute Efforts to Identify Gaps and Opportunities.

Cancer Epidemiol Biomarkers Prev 2020 Jun 12. Epub 2020 Jun 12.

Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

Cancer mortality rates are approximately 8% higher in rural populations and mortality rates are falling more slowly in rural communities, resulting in widening rural-urban health disparities in the United States. The NCI has a long history of supporting health disparities research, including research to understand the health needs, strengths, and opportunities in rural communities. However, the portfolio analysis described in this article underscores the need to significantly accelerate rural cancer control research in partnership with state and local communities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0453DOI Listing

Detection of Head and Neck Cancer Based on Longitudinal Changes in Serum Protein Abundance.

Cancer Epidemiol Biomarkers Prev 2020 Jun 12. Epub 2020 Jun 12.

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington.

Background: Approximately 85% of the U.S. military active duty population is male and less than 50 years of age, with elevated levels of known risk factors for oropharyngeal squamous cell carcinoma (OPSCC), including smoking, excessive use of alcohol, and greater numbers of sexual partners, and elevated prevalence of human papilloma virus (HPV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0192DOI Listing
June 2020
4.125 Impact Factor

Medical Care Costs Associated with Cancer Survivorship in the United States.

Cancer Epidemiol Biomarkers Prev 2020 Jul 10;29(7):1304-1312. Epub 2020 Jun 10.

Surveillance and Health Services Research, American Cancer Society, Atlanta, Georgia.

Background: The prevalence of cancer survivorship is increasing. In this study, we provide contemporary population-based estimates and projections of the overall and site-specific cancer-attributable medical care costs in the United States.

Methods: We identified survivors aged ≥65 years diagnosed with cancer between 2000 and 2012 from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database and used 2007 to 2013 claims to estimate costs by cancer site, phases of care, and stage at diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1534DOI Listing

Diversity of Enrollment in Prostate Cancer Clinical Trials: Current Status and Future Directions.

Cancer Epidemiol Biomarkers Prev 2020 Jul 5;29(7):1374-1380. Epub 2020 Jun 5.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Background: Although there are considerable racial and ethnic disparities in prostate cancer incidence and mortality in the United States and globally, clinical trials often do not reflect disease incidence across racial and ethnic subgroups. This study aims to comprehensively review the reporting of race and ethnicity data and the representation of race and ethnicity across prostate cancer treatment-, prevention-, and screening-based clinical trials.

Methods: Seventy-two global phase III and IV prevention, screening, and treatment prostate cancer clinical trials with enrollment start dates between 1987 and 2016 were analyzed in this study, representing a total of 893,378 individual trial participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334076PMC

The Diet of Higher Insulinemic Potential Is Not Associated with Worse Survival in Patients with Stage III Colon Cancer (Alliance).

Cancer Epidemiol Biomarkers Prev 2020 Jun 4. Epub 2020 Jun 4.

Yale Cancer Center, Yale School of Medicine

Background: Hyperinsulinemia is considered to be important in the development of colon cancer, but few studies have investigated the associations of hyperinsulinemia with colon cancer survival via dietary scores.

Methods: Empirical dietary index for hyperinsulinemia (EDIH) was derived to assess the insulinemic potential of daily diets reflecting the long-term insulin exposure, with higher (more positive) scores indicating higher insulinemic diets. We prospectively estimated the hazard ratios (HR) and 95% confidence intervals (CI) to investigate the association of EDIH with disease-free, recurrence-free, and overall survival among patients with stage III colon cancer (1999-2009) enrolled in a randomized adjuvant chemotherapy trial (CALGB 89803). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1454DOI Listing

Cumulative Burden of Chronic Health Conditions in Adult Survivors of Osteosarcoma and Ewing Sarcoma: A Report from the St. Jude Lifetime Cohort Study.

Cancer Epidemiol Biomarkers Prev 2020 Jun 4. Epub 2020 Jun 4.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Adult survivors of childhood osteosarcoma and Ewing sarcoma are at risk of developing therapy-related chronic health conditions. We characterized the cumulative burden of chronic conditions and health status of survivors of childhood bone sarcomas.

Methods: Survivors ( = 207) treated between 1964 and 2002 underwent comprehensive clinical assessments (history/physical examination, laboratory analysis, and physical and neurocognitive testing) and were compared with community controls ( = 272). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0076DOI Listing

Novel Variants of and in the Interferon Gamma Signaling Pathway Are Associated with Non-Small Cell Lung Cancer Survival.

Cancer Epidemiol Biomarkers Prev 2020 Jun 3. Epub 2020 Jun 3.

Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.

Background: IFNγ is a pleiotropic cytokine that plays critical immunomodulatory roles in intercellular communication in innate and adaptive immune responses. Despite recognition of IFNγ signaling effects on host defense against viral infection and its utility in immunotherapy and tumor progression, the roles of genetic variants of the IFNγ signaling pathway genes in survival of patients with cancer remain unknown.

Methods: We used a discovery genotyping dataset from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial ( = 1,185) and a replication genotyping dataset from the Harvard Lung Cancer Susceptibility Study ( = 984) to evaluate associations between 14,553 genetic variants in 150 IFNγ pathway genes and survival of non-small cell lung cancer (NSCLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1450DOI Listing
June 2020
4.125 Impact Factor

Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk-Response.

Cancer Epidemiol Biomarkers Prev 2020 Jun;29(6):1279

Moffitt Cancer Center, Tampa, Florida.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1388DOI Listing

Copy Number Variation and Ovarian Cancer Risk-Letter.

Cancer Epidemiol Biomarkers Prev 2020 Jun;29(6):1278

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-0944DOI Listing

Prognosis of Patients with Colorectal Cancer with Diabetes According to Medication Adherence: A Population-Based Cohort Study.

Cancer Epidemiol Biomarkers Prev 2020 Jun;29(6):1120-1127

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea (South).

Background: Diabetes mellitus is known to have a negative effect on colorectal cancer survival due to hyperinsulinemia or hyperglycemia, and medications such as metformin, which targets insulin resistance and hyperinsulinemia, have a preventive effect on the risk of death. The aim of this study was to compare the risk of death among patients with colorectal cancer with diabetes with different levels of adherence to oral antidiabetics.

Methods: National Health Information Database was used, which has all claims data for those who are registered for national health insurance in Korea, from 2002 to 2016, for conducting a retrospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1455DOI Listing

Cancer Progress and Priorities: Childhood Cancer.

Cancer Epidemiol Biomarkers Prev 2020 Jun;29(6):1081-1094

Department of Pediatrics, Division of Epidemiology & Clinical Research, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-0941DOI Listing

Selected Articles from This Issue.

Authors:

Cancer Epidemiol Biomarkers Prev 2020 Jun;29(6):1079

View Article

Download full-text PDF

Source

Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Background: Metabolic syndrome (MetS) is a systemic inflammatory state. Low physical activity (PA) could modify this patho-physiology or act as an independent contributor to inflammation. Previous studies of both conditions have identified altered levels of inflammation- and immune-related proteins based on limited sets of candidate markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1513DOI Listing

Colorectal Neoplasia among Patients with and without Human Immunodeficiency Virus.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Increasing availability of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has led to prolonged survival and rising incidence of non-HIV-defining cancers among patients with HIV. Compared with the general population, risk of colorectal cancer may differ among those with HIV due to immunosuppression, oncogenic viral coinfections, and higher prevalence of risk factors.

Methods: We identified patients (age ≥50 years) diagnosed with HIV, prescribed HAART for ≥6 months, and receiving care in two large health care systems in Dallas, TX. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0021DOI Listing

Insulin-Like Growth Factor-1 Receptor Expression and Disease Recurrence and Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Background: Insulin-like growth factor-1 receptor (IGF1R) signaling is important in pancreatic ductal adenocarcinoma (PDAC) biology, but little is known regarding IGF1R expression and patient characteristics and outcomes.

Methods: In 365 patients with resected PDAC, we evaluated IGF1R protein expression using IHC on whole-slide sections and genomic status using next-generation sequencing. Associations of IGF1R expression, measured by H-scores incorporating staining intensity and proportion of positive tumor cells, with disease-free survival (DFS) and overall survival (OS) were evaluated in 317 and 321 patients, respectively, using Cox regression adjusting for known prognostic factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1315DOI Listing

Comparison of Tissue-Based Molecular Markers in Younger versus Older Patients with Colorectal Neoplasia.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Department of Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Emerging colorectal cancer trends demonstrate increased incidence and mortality in younger populations, prompting consideration of average-risk colorectal cancer screening initiation at age 45 versus 50 years. However, screening test performance characteristics in adults 45-49 years have been minimally described. To inform the biologic rationale for multi-target stool DNA (mt-sDNA) screening in younger patients, we analyzed and compared tissue levels of methylation () and mutation () markers included in the FDA-approved, mt-sDNA assay (Cologuard; Exact Sciences Corporation). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1598DOI Listing

Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Children's Health and Discovery Initiative, Department of Pediatrics, Duke University, Durham, North Carolina.

Background: Genome-wide association studies (GWAS) of childhood cancers remain limited, highlighting the need for novel analytic strategies. We describe a hybrid GWAS and phenome-wide association study (PheWAS) approach to uncover genotype-phenotype relationships and candidate risk loci, applying it to acute lymphoblastic leukemia (ALL).

Methods: PheWAS was performed for 12 ALL SNPs identified by prior GWAS and two control SNP-sets using UK Biobank data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0113DOI Listing

Methodologic Considerations in Calculating and Analyzing Proportion of Time Covered as a Measure of Longitudinal Cancer Screening Adherence.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Kaiser Permanente Washington Health Research Institute, Seattle, Washington.

Background: Proportion of time covered (PTC, or "covered time") is a longitudinal measure of adherence to preventive health services, the use of which has increased in recent years. This measure is helpful for evaluating the success of delivering screening interventions over time. However, there are challenges and nuances in computing and interpreting PTC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0388DOI Listing

Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Gran Via de L'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk.

Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0184DOI Listing

A Systematic Literature Review of Whole Exome and Genome Sequencing Population Studies of Genetic Susceptibility to Cancer.

Cancer Epidemiol Biomarkers Prev 2020 May 28. Epub 2020 May 28.

National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland.

The application of next-generation sequencing (NGS) technologies in cancer research has accelerated the discovery of somatic mutations; however, progress in the identification of germline variation associated with cancer risk is less clear. We conducted a systematic literature review of cancer genetic susceptibility studies that used NGS technologies at an exome/genome-wide scale to obtain a fuller understanding of the research landscape to date and to inform future studies. The variability across studies on methodologies and reporting was considerable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1551DOI Listing

Challenges and Approaches to Measuring Repeat Fecal Immunochemical Test for Colorectal Cancer Screening.

Cancer Epidemiol Biomarkers Prev 2020 May 26. Epub 2020 May 26.

Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Colorectal cancer screening with fecal immunochemical testing (FIT) can reduce colorectal cancer-related mortality. Effectiveness of FIT may be compromised when patients do not adhere to a regular schedule. However, having no standard measure of repeat FIT presents challenges for assessing effectiveness across populations and settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0230DOI Listing

Impact of Tobacco Control Policies on Smoking-Related Cancer Incidence in Germany 2020 to 2050-A Simulation Study.

Cancer Epidemiol Biomarkers Prev 2020 Jul 26;29(7):1413-1422. Epub 2020 May 26.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: Germany is known for its weak tobacco control. We aimed to provide projections of potentially avoidable cancer cases under different tobacco control policy intervention scenarios.

Methods: To estimate numbers and proportions of potentially avoidable cancer cases under different policy intervention scenarios (cigarette price increases, comprehensive marketing ban, and plain packaging), we calculated cancer site-specific potential impact fractions by age, sex, and year of study period (2020-2050), considering latency periods between reduction in smoking prevalence and manifestation in declining cancer excess risks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1301DOI Listing

Variation in Cervical Cancer Screening Preferences among Medically Underserved Individuals in the United States: A Systematic Review.

Cancer Epidemiol Biomarkers Prev 2020 May 26. Epub 2020 May 26.

Department of Health Policy & Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Underutilization of effective screening is one driver of disparities in cervical cancer incidence and mortality. Consideration of patient preferences could help to improve screening rates in populations facing substantial barriers to preventive care. We conducted a systematic review of the literature on cervical cancer screening preferences among medically underserved patients in the United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0306DOI Listing

Serum Iodine and Breast Cancer Risk: A Prospective Nested Case-Control Study Stratified for Selenium Levels.

Cancer Epidemiol Biomarkers Prev 2020 Jul 26;29(7):1335-1340. Epub 2020 May 26.

Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Iodine has been suggested to protect against breast cancer, but there are no epidemiologic studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0122DOI Listing

Hematologic Markers and Prostate Cancer Risk: A Prospective Analysis in UK Biobank.

Cancer Epidemiol Biomarkers Prev 2020 May 26. Epub 2020 May 26.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Background: Risk factors for prostate cancer are not well understood. Red blood cell, platelet, and white blood cell indices may be markers of a range of exposures that might be related to prostate cancer risk. Therefore, we examined the associations of hematologic parameters with prostate cancer risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1525DOI Listing

Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk.

Cancer Epidemiol Biomarkers Prev 2020 Jul 21;29(7):1501-1508. Epub 2020 May 21.

Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with few known risk factors and biomarkers. Several blood protein biomarkers have been linked to PDAC in previous studies, but these studies have assessed only a limited number of biomarkers, usually in small samples. In this study, we evaluated associations of circulating protein levels and PDAC risk using genetic instruments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334065PMC

Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis.

Cancer Epidemiol Biomarkers Prev 2020 May 19. Epub 2020 May 19.

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Background: Experimental evidence suggests that dietary intakes of omega-3 and omega-6 polyunsaturated fatty acids have divergent effects on melanoma growth, but epidemiologic evidence on their combined effect is lacking.

Methods: In 634 Australian patients with primary melanoma, we assessed prediagnosis consumption of 39 food groups by food frequency questionnaires completed within 2 months of diagnosis. We derived, by reduced rank regression, dietary patterns that explained variability in selected omega-3 and omega-6 fatty acid intakes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0319DOI Listing

DNA Methylation-Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk.

Cancer Epidemiol Biomarkers Prev 2020 May 19. Epub 2020 May 19.

Department of Epidemiology, Brown University, Providence, Rhode Island.

Background: Pancreatic cancer is projected to become the second most common cause of cancer-related death over the next 5 years. Because inflammation is thought to be a common trajectory for disease initiation, we sought to prospectively characterize immune profiles using DNA methylation markers and examine DNA methylation levels previously linked to inflammation biomarkers to evaluate whether these immune markers play a key role in pancreatic cancer.

Methods: In a nested case-control study pooling three U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0378DOI Listing
May 2020
4.125 Impact Factor

Prevalence of Healthy Behaviors among Cancer Survivors in the United States: How Far Have We Come?

Cancer Epidemiol Biomarkers Prev 2020 Jun 14;29(6):1179-1187. Epub 2020 May 14.

University of Nebraska Medical Center, Omaha, Nebraska.

Background: The 16.9 million cancer survivors in the United States are at increased risk for comorbidities and recurrence. However, this risk may be attenuated by a healthy lifestyle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1318DOI Listing

Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients.

Cancer Epidemiol Biomarkers Prev 2020 May 13. Epub 2020 May 13.

Huntsman Cancer Institute, Cancer Control and Population Sciences, University of Utah, Salt Lake City, Utah.

Background: Air pollution is a carcinogen and causes pulmonary and cardiac complications. We examined the association of fine particulate matter pollution (PM) and mortality from cancer and all causes among pediatric, adolescent, and young adult (AYA) patients with cancer in Utah, a state with considerable variation in PM.

Methods: We followed 2,444 pediatric (diagnosed ages 0-14) and 13,459 AYA (diagnosed ages 15-39) patients diagnosed in 1986-2015 from diagnosis to 5 and 10 years postdiagnosis, death, or emigration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1363DOI Listing

Is Gliclazide Associated with a Lower Obesity-Related Cancer Risk Compared to Other Sulfonylureas? A Long-term Prospective Cohort Study.

Cancer Epidemiol Biomarkers Prev 2020 May 13. Epub 2020 May 13.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Gliclazide has been suspected to be associated with a lower obesity-related cancer risk; however, current evidence is limited by important methodologic shortcomings. This study aimed to evaluate whether gliclazide is preferred over other sulfonylureas regarding obesity-related cancer risk.

Methods: In this prospective cohort study, an annual benchmarking database in Dutch primary care (Zwolle Outpatient Diabetes project Integrating Available CareZODIAC, 1998-2014) was linked to the Netherlands Cancer Registry and the Dutch Personal Record Database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1517DOI Listing

Increasing Incidence of Testicular Germ Cell Tumors among Racial/Ethnic Minorities in the United States.

Cancer Epidemiol Biomarkers Prev 2020 Jun 8;29(6):1237-1245. Epub 2020 May 8.

National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.

Background: The incidence of testicular germ cell tumors (TGCT) has been rising in the United States and is notably higher among white men. Previously, our group reported that rates were rising among Hispanic men in certain areas. This study sought to determine whether the patterns noted in our prior publication remained evident in more recent years and to determine whether any new patterns have emerged. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269801PMC

Hazard of Cervical, Oropharyngeal, and Anal Cancers in HIV-Infected and HIV-Uninfected Medicaid Beneficiaries.

Cancer Epidemiol Biomarkers Prev 2020 Jul 8;29(7):1447-1457. Epub 2020 May 8.

Brown University School of Public Health, Providence, Rhode Island.

Background: Human immunodeficiency virus-infected (HIV) individuals are disproportionately at risk for human papillomavirus (HPV)-associated cancers, but the magnitude of risk estimates varies widely. We conducted a retrospective study using a large U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334054PMC

The Four-Kallikrein Panel Is Effective in Identifying Aggressive Prostate Cancer in a Multiethnic Population.

Cancer Epidemiol Biomarkers Prev 2020 Jul 8;29(7):1381-1388. Epub 2020 May 8.

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: The four-kallikrein (4K) panel has been demonstrated to improve prediction of aggressive prostate cancer compared with prostate-specific antigen (PSA) among men with moderately elevated PSA levels. However, the development and testing of the 4K panel has been conducted primarily in White men, with limited data in African Americans and no studies in other racial and ethnic groups.

Methods: We evaluated the 4K panel in a nested case-control study among African American, Latino, Japanese, Native Hawaiian, and White men in the Multiethnic Cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334056PMC
July 2020
4.125 Impact Factor

Effect of a Digital Health Intervention on Decreasing Barriers and Increasing Facilitators for Colorectal Cancer Screening in Vulnerable Patients.

Cancer Epidemiol Biomarkers Prev 2020 May 7. Epub 2020 May 7.

Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Background: Colorectal cancer is the second leading cause of cancer-related death in the United States, in part, because one third of Americans fail to get screened. In a prior randomized controlled trial, we found that an iPad patient decision aid called Mobile Patient Technology for Health-CRC (mPATH-CRC) doubled the proportion of patients who completed colorectal cancer screening.

Methods: All data for the current analysis were collected as part of a randomized controlled trial to determine the impact of mPATH-CRC on receipt of colorectal cancer screening within 24 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1199DOI Listing
May 2020
4.125 Impact Factor

Changes in Colorectal Cancer 5-Year Survival Disparities in California, 1997-2014.

Cancer Epidemiol Biomarkers Prev 2020 Jun 5;29(6):1154-1161. Epub 2020 May 5.

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.

Background: Colorectal cancer incidence and mortality have declined with increased screening and scientific advances in treatment. However, improvement in colorectal cancer outcomes has not been equal for all groups and disparities have persisted over time.

Methods: Data from the California Cancer Registry were used to estimate changes in 5-year colorectal cancer-specific survival over three diagnostic time periods: 1997-2002, 2003-2008, and 2009-2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-19-1544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269803PMC

The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action.

Cancer Epidemiol Biomarkers Prev 2020 Jul 5;29(7):1283-1289. Epub 2020 May 5.

Zoe Global Limited, London, United Kingdom.

The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. We established the COronavirus Pandemic Epidemiology (COPE) consortium to address this unprecedented crisis on behalf of the epidemiology research community. As a central component of this initiative, we have developed a COVID Symptom Study (previously known as the COVID Symptom Tracker) mobile application as a common data collection tool for epidemiologic cohort studies with active study participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-20-0606DOI Listing
July 2020
4.125 Impact Factor