1,132 results match your criteria Cancer Cytopathol[Journal]


Immediate histologic correlation in women with atypical squamous cells of undetermined significance cytology and positive high-risk HPV: A retrospective review of 6000 cases in a large academic women's hospital.

Cancer Cytopathol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: Previous studies of the histologic correlation in women who have atypical squamous cells of undetermined significance cytology (ASC-US) and are positive for high-risk human papillomavirus (hrHPV+) have predominantly utilized the Hybrid Capture 2 (HC2) test, whereas the use of other US Food and Drug Administration (FDA)-approved methods is relatively limited.

Methods: Cases of ASC-US/hrHPV+ that were tested using HC2, Cervista, or Aptima were retrieved, and the immediate histologic correlations were analyzed.

Results: Overall, 53. Read More

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http://dx.doi.org/10.1002/cncy.22314DOI Listing

Immunocytochemistry practices in European cytopathology laboratories-Review of European Federation of Cytology Societies (EFCS) online survey results with best practice recommendations.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Cochin Hospital, University Paris, Paris, France.

Background: Variability in preanalytical and analytical steps for immunocytochemistry (ICC) on cytology samples is poorly defined. The objective of this study was to evaluate current practices for ICC on cytology samples in European laboratories.

Methods: A link to an online survey with 19 questions about ICC practices was distributed to cytology laboratories through national representatives in the European Federation of Cytology Societies. Read More

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http://dx.doi.org/10.1002/cncy.22311DOI Listing

Health disparities in cervical cancer: Prevalence of high-risk HPV and cytologic diagnoses according to race.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Background: In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and black women compared with white women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among black and white women over a 24-month period. They then assessed the rates in young women in 2011 compared with 2017 according to race. Read More

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http://dx.doi.org/10.1002/cncy.22316DOI Listing

Next-generation sequencing of residual cytologic fixative preserved DNA from pancreatic lesions: A pilot study.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

The Leopold G. Koss Division of Cytology, The Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.

Background: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a sensitive and specific tool in the risk stratification of pancreatic lesions, including cysts. The sensitivity and specificity of EUS-FNA has been shown to improve when cytology is combined with next-generation sequencing (NGS). Ideally, fresh cyst fluid is used for NGS. Read More

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http://dx.doi.org/10.1002/cncy.22315DOI Listing

Insulinoma-associated protein 1 immunostaining for various types of neuroendocrine tumors on FNA smears.

Cancer Cytopathol 2020 Jun 23. Epub 2020 Jun 23.

Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Insulinoma-associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin-embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied. This study investigated the performance of INSM1 staining on cytologic smears for the detection of various NETs in comparison with chromogranin (CG) and synaptophysin (SYN).

Methods: INSM1, CG, and SYN were stained on cytologic smears of 70 NETs, including 20 pancreatic NETs, 10 lung carcinoid tumors, 11 small cell lung carcinomas (SCLCs), 10 medullary thyroid carcinomas, 10 Merkel cell carcinomas, 4 thymic atypical carcinoid tumors, and 5 olfactory neuroblastomas. Read More

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http://dx.doi.org/10.1002/cncy.22310DOI Listing

Interobserver variability between cytopathologists and cytotechnologists upon application and characterization of the indeterminate category in the Milan system for reporting salivary gland cytopathology.

Cancer Cytopathol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology and Laboratory Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Background: The indeterminate categories in the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) are diagnostically challenging because of inherent heterogeneity and complexity, with wide interobserver variability (IOV). Herein, the authors explore the concordance rate (CR) between cytopathologists (CPs) and cytotechnologists (CTs) in interpreting indeterminate salivary gland lesions using the MSRSGC.

Methods: Between 2011 and 2016, 86 indeterminate fine-needle aspirations had slides available for review, of which 48 had follow-up. Read More

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http://dx.doi.org/10.1002/cncy.22312DOI Listing

Reduction of diagnostic error: Following cytopathology's lead.

Authors:
Yael K Heher

Cancer Cytopathol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncy.22308DOI Listing

Measures to reduce diagnostic error and improve clinical decision making in thyroid FNA aspiration cytology: A proposed framework.

Cancer Cytopathol 2020 Jun 16. Epub 2020 Jun 16.

SYNLAB Suisse SA, Lausanne, Switzerland.

Thyroid fine-needle aspiration cytology (FNA) and histopathology can be subjective areas of medical diagnosis and subject to different interpretations. On the basis of the authors' personal experience, 12 recommendations with potential to improve clinical decision making, ensure quality, and reduce diagnostic error in thyroid FNAC and histopathology are presented. 1) use a standardized reporting terminology for thyroid FNAC; 2) understand and explain to service users the limitations of cytology and the standardized thyroid FNAC reporting terminology used; 3) the cytopathologist should review all relevant clinical and ultrasound findings, if feasible; 4) include the risk of malignancy in all FNAC reports if feasible; 5) collect data to calculate the local institutional risk of malignancy for FNAC if feasible; 6) accept that nondiagnostic FNAC will include small numbers of carcinomas; 7) use rapid on-site evaluation and/or educational sessions for aspirators if the nondiagnostic aspiration rate is high; 8) know the diagnostic pitfalls of both cytology and histopathology; 9) use special immunohistochemical and molecular techniques that are evidence-based; 10) make use of second opinions, either in-house or interinstitutional; 11) multidisciplinary discussion of cases before surgery or therapy is invaluable; and, finally, 12) manage patient and clinician expectations of thyroid cytology and histopathology. Read More

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http://dx.doi.org/10.1002/cncy.22309DOI Listing

Nondiagnostic fine needle aspirates of the pancreas: A root cause analysis.

Cancer Cytopathol 2020 Jun 11. Epub 2020 Jun 11.

Department of Pathology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Background: Fine needle aspiration (FNA) of the pancreas is considered the primary and least invasive diagnostic method in the evaluation of pancreatic lesions. A nondiagnostic sample may trigger repeat FNA or a more invasive diagnostic procedure. The goal of this study was to identify the root causes of nondiagnostic samples. Read More

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http://dx.doi.org/10.1002/cncy.22301DOI Listing

Benefit of double-reading cytology smears as a triage strategy among high-risk human papillomavirus-positive women in Mexico.

Cancer Cytopathol 2020 Jun 10. Epub 2020 Jun 10.

Centro de Investigación en Salud Poblacional. Instituto Nacional de Salud Pública, Cuernavaca, Mexico.

Background: The goal of this study was to determine whether the detection of histologically confirmed cases of cervical high-grade squamous intraepithelial lesions or worse (HSIL+) can be increased by having each liquid-based cytology (LBC) slide read by 2 cytotechnologists as part of routine screening.

Methods: Over 36,212 women aged 30 to 64 years participated in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage (FRIDA) Study in Mexico between 2013 and 2016. For each participant, 2 cervical samples were collected at the same clinic visit, one to test for high-risk human papillomavirus (hrHPV) and the other for LBC, which was used to triage those with a hrHPV positive result. Read More

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http://dx.doi.org/10.1002/cncy.22303DOI Listing

A new guideline from the College of American Pathologists to improve the adequacy of thoracic small specimens for ancillary studies.

Cancer Cytopathol 2020 Jun 10. Epub 2020 Jun 10.

Division of Pathology and Laboratory Medicine, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1002/cncy.22299DOI Listing

Postoperative circulating tumor cells: An early predictor of extrahepatic metastases in patients with hepatocellular carcinoma undergoing curative surgical resection.

Cancer Cytopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Postoperative extrahepatic metastases (EHM) contribute to a grim outcome in patients with hepatocellular carcinoma (HCC) who are undergoing curative surgical resection. The current study investigated the clinical value of circulating tumor cells (CTCs) in predicting EHM after curative surgery.

Methods: A total of 197 patients with HCC who were undergoing curative surgical resection were assigned to a retrospective training cohort (144 patients) or a prospective validation cohort (53 patients). Read More

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http://dx.doi.org/10.1002/cncy.22304DOI Listing

Reply to Rapid on-site evaluation and the COVID-19 pandemic.

Cancer Cytopathol 2020 Jun 5. Epub 2020 Jun 5.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.

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http://dx.doi.org/10.1002/cncy.22296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300869PMC
June 2020
3.354 Impact Factor

Abnormal cytology in oropharyngeal brushings and in oral rinses is not associated with HPV infection: The OHMAR study.

Cancer Cytopathol 2020 Jun 2. Epub 2020 Jun 2.

Sexually Transmitted Infection/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Background: No screening is available for human papillomavirus (HPV)-associated oropharyngeal cancers. The authors investigated whether cytology may be used as a screening tool and whether oral HPV infection is associated with cytologic abnormalities detected in oropharyngeal brushings and in oral rinse-and-gargle specimens from asymptomatic individuals at increased risk for oral HPV infection.

Methods: Specimens were collected from men who have sex with men at 6-month intervals. Read More

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http://dx.doi.org/10.1002/cncy.22295DOI Listing

Thyroid FNA in the time of coronavirus: The interventional cytopathologist point of view.

Cancer Cytopathol 2020 May 28. Epub 2020 May 28.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/cncy.22294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283821PMC

Comparative analysis of programmed death ligand 1 expression in paired cytologic and histologic specimens of non-small cell lung cancer.

Cancer Cytopathol 2020 May 28. Epub 2020 May 28.

Pathology Unit, University of Piemonte Orientale, Azienda Ospedaliero Universitaria Maggiore della Carità di Novara, Novara, Italy.

Background: In advanced non-small cell lung cancer (NSCLC), cytologic specimens from transbronchial needle aspiration (TBNA) or transthoracic needle aspiration are often the only cancer tissue material available for the analysis of programmed death ligand 1 (PD-L1) expression. This study was aimed at assessing the concordance of PD-L1 expression in histologic and cytologic samples and at evaluating interobserver agreement on specimens in this setting.

Methods: One hundred and thirty-eight specimens from 60 patients with NSCLC were analyzed. Read More

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http://dx.doi.org/10.1002/cncy.22292DOI Listing

Rapid on-site evaluation and the COVID-19 pandemic.

Cancer Cytopathol 2020 May 28. Epub 2020 May 28.

Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.1002/cncy.22297DOI Listing

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Cancer Cytopathol 2020 May 18. Epub 2020 May 18.

Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.

Salivary duct carcinoma (SDC) is an aggressive subtype of primary salivary gland carcinoma, often with an advanced stage at presentation and high rates of metastasis and recurrence. It most commonly arises in the parotid gland of older men and microscopically resembles high-grade breast ductal carcinoma. While 50 years have lapsed since the first report of this entity, recent intensive studies have shed light on its biologic, genetic, and clinical characteristics. Read More

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http://dx.doi.org/10.1002/cncy.22288DOI Listing

Ki-67 proliferation index in neuroendocrine tumors: Can augmented reality microscopy with image analysis improve scoring?

Cancer Cytopathol 2020 May 13. Epub 2020 May 13.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: The Ki-67 index is important for grading neuroendocrine tumors (NETs) in cytology. However, different counting methods exist. Recently, augmented reality microscopy (ARM) has enabled real-time image analysis using glass slides. Read More

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http://dx.doi.org/10.1002/cncy.22272DOI Listing

Erratum.

Authors:

Cancer Cytopathol 2020 May 4;128(5):359-360. Epub 2019 Dec 4.

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http://dx.doi.org/10.1002/cncy.22210DOI Listing

Erratum.

Authors:

Cancer Cytopathol 2020 May 18;128(5):360. Epub 2020 Apr 18.

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http://dx.doi.org/10.1002/cncy.22274DOI Listing

Spotlight: Rising stars in cytology.

Authors:
Kaitlin Sundling

Cancer Cytopathol 2020 Jun 4;128(6):369-370. Epub 2020 May 4.

Department of Pathology and Laboratory Medicine, University of Wisconsin.

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http://dx.doi.org/10.1002/cncy.22285DOI Listing

Role of FNA with core biopsy or cell block in patients with nodular lymphocyte-predominant Hodgkin lymphoma.

Cancer Cytopathol 2020 Apr 28. Epub 2020 Apr 28.

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Background: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) represents a diagnostic challenge on surgical excisional or incisional biopsy. Classification is further challenging on fine needle aspiration (FNA) material accompanied by needle core and/or cell block biopsy (FNA+core/CB).

Methods: The authors studied all FNA+core/CB and surgical excisional or incisional biopsies to evaluate for lymphoma in patients who had a prior history of NLPHL or subsequent diagnosis of NLPHL over a 5-year period from 2012 through 2016. Read More

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http://dx.doi.org/10.1002/cncy.22286DOI Listing

High-risk and intermediate-high-risk results from the ThyroSeq v2 and v3 thyroid genomic classifier are associated with neoplasia: Independent performance assessment at an academic institution.

Cancer Cytopathol 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Duke University Medical Center, Durham, North Carolina.

Background: The ThyroSeq panel tests for genetic alterations to risk-stratify cytologically indeterminate nodules. The authors assessed the test performance of the tests, including the latest version (v3), at an academic center.

Methods: Results from ThyroSeq testing (v2 and v3) were reviewed over 2 years, and patient demographics, cytology diagnoses, results of ThyroSeq testing, and histopathologic diagnoses on resection (if available) were collected. Read More

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http://dx.doi.org/10.1002/cncy.22283DOI Listing

Reply to Scoring of PD-L1 positivity: Are we analyzing enough cells?

Cancer Cytopathol 2020 Jun 27;128(6):424-425. Epub 2020 Apr 27.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1002/cncy.22282DOI Listing

Scoring of PD-L1 positivity: Are we analyzing enough cells?

Cancer Cytopathol 2020 Jun 27;128(6):424. Epub 2020 Apr 27.

Department of Internal Medicine, University of Campinas, Campinas, Brazil.

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http://dx.doi.org/10.1002/cncy.22284DOI Listing

Identification of circulating tumor cells using 4-color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low-dose computed tomography-detected lung nodules.

Cancer Cytopathol 2020 Apr 22. Epub 2020 Apr 22.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Approximately one third of needle biopsies that are performed to rule out malignancy of indeterminate pulmonary nodules detected radiologically during lung cancer screening are negative, thus exposing cancer-free patients to risks of pneumothorax, bleeding, and infection. A noninvasive confirmatory tool (eg, liquid biopsy) is urgently needed in the lung cancer diagnosis setting to stratify patients who should receive biopsy versus those who should be monitored.

Methods: A novel antigen-independent, 4-color fluorescence in situ hybridization (FISH)-based method was developed to detect circulating tumor cells (CTCs) with abnormalities in gene copy numbers in mononuclear cell-enriched peripheral blood samples from patients with (n = 107) and without (n = 100) lung cancer. Read More

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http://dx.doi.org/10.1002/cncy.22278DOI Listing

Detection and comparison of EGFR mutations from supernatants that contain cell-free DNA and cell pellets from FNA non-small cell lung cancer specimens.

Cancer Cytopathol 2020 Apr 14. Epub 2020 Apr 14.

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Background: Epidermal growth factor receptor (EGFR) is an important marker for targeted therapy in patients with advanced non-small cell lung cancer (NSCLC). The samples obtained with minimally invasive biopsy techniques are usually small, and this limits their application in tissue subtyping or molecular profiling. The supernatants obtained after centrifugation of fine-needle aspiration (FNA) samples are typically discarded. Read More

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http://dx.doi.org/10.1002/cncy.22273DOI Listing

Preanalytic variables in quality and quantity of nucleic acids extracted from FNA specimens of thyroid gland nodules collected in CytoLyt: Cellularity and storage time.

Cancer Cytopathol 2020 Apr 8. Epub 2020 Apr 8.

Clinical Genomics Laboratory, Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital-Weill Cornell Medical College, New York, New York.

Background: Morphologic and genetic analysis of thyroid nodules may be performed from a single vial. Preanalytic variables that affect nucleic acid extracted from a single vial are evaluated.

Methods: Thyroid fine-needle aspiration (FNA) specimens collected in CytoLyt were evaluated. Read More

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http://dx.doi.org/10.1002/cncy.22270DOI Listing

Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel.

Cancer Cytopathol 2020 Jun 8;128(6):392-402. Epub 2020 Apr 8.

Department of Pathology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts.

Background: Fine needle aspiration (FNA) is commonly used for the preoperative evaluation of salivary gland tumors. Tumor grade is a key factor influencing clinical management of salivary gland carcinomas (SGCs). To assess the ability to grade nonbasaloid SGCs in FNA specimens, an international panel of cytopathologists convened to review and score SGC cases. Read More

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http://dx.doi.org/10.1002/cncy.22271DOI Listing

Biosafety in the preparation and processing of cytology specimens with potential coronavirus (COVID-19) infection: Perspectives from Taiwan.

Cancer Cytopathol 2020 05 7;128(5):309-316. Epub 2020 Apr 7.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.

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http://dx.doi.org/10.1002/cncy.22280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262216PMC
May 2020
3.354 Impact Factor

Going remote: Maintaining normalcy in our pathology laboratories during the COVID-19 pandemic.

Authors:
Emilio Madrigal

Cancer Cytopathol 2020 May 7;128(5):321-322. Epub 2020 Apr 7.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncy.22276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262355PMC

International perspectives: Impact of the COVID-19 pandemic on cytology.

Cancer Cytopathol 2020 05 7;128(5):307-308. Epub 2020 Apr 7.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/cncy.22275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262335PMC

Cytologic and histologic samples from patients infected by the novel coronavirus 2019 SARS-CoV-2: An Italian institutional experience focusing on biosafety procedures.

Cancer Cytopathol 2020 May 7;128(5):317-320. Epub 2020 Apr 7.

Unit of Anatomic Pathology, Agostino Gemelli University Policlinic Foundation, IRCCS, Rome, Italy.

The 2019 coronavirus pandemic, which started in Wuhan, China, spread around the globe with dramatic and lethal effects. From the initial Chinese epicenter, the European diaspora taxed the resources of several countries and especially those of Italy, which was forced into a complete social and economic shutdown. Infection by droplets contaminating hands and surfaces represents the main vehicle of diffusion of the virus. Read More

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http://dx.doi.org/10.1002/cncy.22281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262363PMC

Racial differences in HPV type 16 prevalence in women with ASCUS of the uterine cervix.

Cancer Cytopathol 2020 Apr 3. Epub 2020 Apr 3.

National Cancer Institute, Rockville, Maryland.

Background: Understanding racial influences on human papillomavirus (HPV) distribution in women with atypical squamous cells of undetermined significance (ASCUS) cytology via partial genotyping in a statewide population can inform HPV-based prevention efforts.

Methods: Women aged 21 to 65 years with any cytology result and partial HPV genotyping for ASCUS triage between January 1, 2014, and December 31, 2017, were included. All women attended a Mississippi State Department of Health clinic. Read More

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http://dx.doi.org/10.1002/cncy.22267DOI Listing
April 2020
3.354 Impact Factor

Sensitivity of cervico-vaginal cytology in endometrial carcinoma: A systematic review and meta-analysis.

Cancer Cytopathol 2020 Mar 23. Epub 2020 Mar 23.

Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.

Cervico-vaginal cytology is primarily a cervical cancer screening test. The anatomical continuity of the uterine cavity with the cervix makes the Papanicolaou (Pap) test accessible to evaluate signs of disease shed from the endometrium. Our aim was to determine the sensitivity of routine Pap test in endometrial carcinoma detection and its relationship with clinico-pathologic factors. Read More

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http://dx.doi.org/10.1002/cncy.22266DOI Listing

Mismatch repair from Lynch syndrome to immunotherapy: A brief primer for cytopathologists.

Authors:
Sarah E Kerr

Cancer Cytopathol 2020 Mar 20. Epub 2020 Mar 20.

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http://dx.doi.org/10.1002/cncy.22263DOI Listing

The diagnostic utility of next-generation sequencing on FNA biopsies of melanocytic uveal lesions.

Cancer Cytopathol 2020 Jul 20;128(7):499-505. Epub 2020 Mar 20.

Department of Pathology, University of California, San Francisco, San Francisco, California.

Background: Uveal melanoma is highly aggressive, and overall prognosis depends on mutation status. Fine-needle aspiration biopsies (FNABs) play an important role in obtaining fresh tissue for cytologic diagnosis and molecular studies. It has been suggested that, although FNAB usually provides high diagnostic accuracy, there may be limited cellularity, which may compromise diagnostic potential for molecular studies. Read More

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http://dx.doi.org/10.1002/cncy.22264DOI Listing

Interlaboratory concordance of p16/Ki-67 dual-staining interpretation in HPV-positive women in a screening population.

Cancer Cytopathol 2020 May 12;128(5):323-332. Epub 2020 Feb 12.

Epidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS of Reggio Emilia, Reggio Emilia, Italy.

Background: p16/Ki-67 dual staining is a candidate biomarker for triaging human papillomavirus (HPV)-positive women. Reproducibility is needed for adopting a test for screening. This study assessed interlaboratory reproducibility in HPV-positive women. Read More

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http://dx.doi.org/10.1002/cncy.22248DOI Listing

The utilization and utility of immunostains in body fluid cytology.

Cancer Cytopathol 2020 Jun 12;128(6):384-391. Epub 2020 Mar 12.

Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, Illinois.

Background: Body fluid cytology (BFC) is an important tool in the diagnosis and staging of malignancy and is aided by the judicious use of immunohistochemistry (IHC). The aim of this study was to determine the usage rates of IHC stains in BFC, their type and indications, and their diagnostic impact. We also attempted to estimate the optimal rate of IHC use in BFC by comparing the entire laboratory's and each individual cytopathologist's IHC use rates with their respective indeterminate and malignant diagnosis rates. Read More

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http://dx.doi.org/10.1002/cncy.22256DOI Listing
June 2020
3.354 Impact Factor

Serous cavity fluids: Momentum, molecules, markers… and more!

Authors:
Momin T Siddiqui

Cancer Cytopathol 2020 Jun 12;128(6):381-383. Epub 2020 Mar 12.

Department of Pathology and Laboratory Medicine, Weill-Cornell Medicine, New York Presbyterian Hospital, New York, New York.

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http://dx.doi.org/10.1002/cncy.22255DOI Listing